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CRISPR/Cas9 System-Mediated Multi-copy Expression of an Alkaline Serine Protease in for the Production of XOD-Inhibitory Peptides
Authors: Shounan Wang, Yibin Xue, Peng Zhang, Qiaojuan Yan, Yanxiao Li, Zhengqiang Jiang
Journal: J Agric Food Chem
PubMed ID: 37807677
Doi: 10.1021/acs.jafc.3c04138
Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies
Authors: Matthias Schmidt, Namil Lee, Chunjun Zhan, Jacob B Roberts, Alberto A Nava, Leah S Keiser, Aaron A Vilchez, Yan Chen, Christopher J Petzold, Robert W Haushalter, Lars M Blank, Jay D Keasling
Journal: ACS Synth Biol
PubMed ID: 37851920
Doi: 10.1021/acssynbio.3c00367
Cornelia de Lange Syndrome mutations in SMC1A cause cohesion defects in yeast
Authors: Jingrong Chen, Erin N Floyd, Dean S Dawson, Susannah Rankin
Journal: Genetics
PubMed ID: 37650609
Doi: 10.1093/genetics/iyad159
The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance
Authors: Matthew K McElwee, Thamotharampillai Dileepan, Shawn A Mahmud, Marc K Jenkins
Journal: J Exp Med
PubMed ID: 37831103
Doi: 10.1084/jem.20230209
Products & Services: Peptide Synthesis   
Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform
Authors: Alexander Ernst, Indre Piragyte, Ayisha Marwa Mp, Ngoc Dung Le, Denis Grandgirard, Stephen L Leib, Andrew Oates, Nadia Mercader
Journal: Sci Rep
PubMed ID: 37813860
Doi: 10.1038/s41598-023-43911-3
Products & Services: Molecular Biology Reagents   
Allele-dependent expression and functionality of lipid enzyme PDAT affects diatom carbon storage and growth
Authors: Yufang Pan, Wanting Zhang, Xiaofei Wang, Juliette Jouhet, Eric Maréchal, Jin Liu, Xiao-Qin Xia, Hanhua Hu
Journal: Plant Physiol
PubMed ID: 37930282
Doi: 10.1093/plphys/kiad581
Products & Services: Monoclonal Antibody Services   
Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells
Authors: Paalini Sathiyaseelan, Suganthi Chittaranjan, Steve E Kalloger, Jennifer Chan, Nancy E Go, Mario A Jardon, Cally J Ho, Theodore Hui, Jing Xu, Christine Chow, Dongxia Gao, Fraser D Johnson, William W Lockwood, Gregg B Morin, Daniel J Renouf, David F Schaeffer, Sharon M Gorski
Journal: J Cell Sci
PubMed ID: 37701987
Doi: 10.1242/jcs.260644
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The Exocyst Subunit CsExo70B Promotes Both Fruit Length and Disease Resistance via Regulating Receptor Kinase Abundance at Plasma Membrane in Cucumber
Authors: Liu Liu , Jiacai Chen , Chaoheng Gu , Shaoyun Wang , Yufan Xue , Zhongyi Wang , Lijie Han , Weiyuan Song , Xiaofeng Liu , Jiahao Zhang , Min Li , Chuang Li , Liming Wang , Xiaolan Zhang , Zhaoyang Zhou
Journal: Plant Biotechnol J .
PubMed ID: 37795910
Doi: 10.1111/pbi.14189
Products & Services: Peptide Synthesis   
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo
Authors: Eirini Giannakopoulou , Madeleine Lehander , Stina Virding Culleton , Weiwen Yang , Yingqian Li , Terhi Karpanen , Tetsuichi Yoshizato , Even H Rustad , Morten Milek Nielsen , Ravi Chand Bollineni , Trung T Tran , Marina Delic-Sarac , Thea Johanne Gjerdingen , Karolos Douvlataniotis , Maarja Laos , Muhammad Ali , Amy Hillen , Stefania Mazzi , Desmond Wai Loon Chin , Adi Mehta , Jeppe Sejerø Holm , Amalie Kai Bentzen , Marie Bill , Marieke Griffioen , Tobias Gedde-Dahl, Sören Lehmann , Sten Eirik W Jacobsen , Petter S Woll , Johanna Olweus
Journal: Nat Cancer .
PubMed ID: 37783807
Doi: 10.1038/s43018-023-00642-8
Products & Services: Gene Synthesis   Peptide Synthesis   
Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2
Authors: Bradly Burke, Savannah M Rocha, Shijun Zhan, Miles Eckley, Clara Reasoner, Amin Addetia, Juliette Lewis, Anna Fagre, Phillida A Charley, Juergen A Richt, Susan R Weiss, Ronald B Tjalkens, David Veesler, Tawfik Aboellail, Tony Schountz
Journal: PLoS Pathog
PubMed ID: 37856551
Doi: 10.1371/journal.ppat.1011728
Fasciola hepatica antioxidant and protease-inhibitor cocktail recombinant vaccines administered five times elicit potent and sustained immune responses in sheep but do not confer protection
Authors: Krystyna Cwiklinski, Amanda McEvoy, Jesús López Corrales, Heather Jewhurst, Nichola Eliza Davies Calvani, Carolina De Marco Verissimo, Amber Louise Dorey, Orla M Keane, John Pius Dalton, Richard Lalor
Journal: Vet Parasitol
PubMed ID: 37826973
Doi: 10.1016/j.vetpar.2023.110049
Identification and evaluation in-vitro of conserved peptides with high affinity to MHC-I as potential protective epitopes for Newcastle disease virus vaccines
Authors: Luis Tataje-Lavanda, Edith Málaga, Manuela Verastegui, Egma Mayta Huatuco, Eliana Icochea, Manolo Fernández-Díaz, Mirko Zimic
Journal: BMC Vet Res
PubMed ID: 37805566
Doi: 10.1186/s12917-023-03726-w
Products & Services: Molecular Biology Reagents   
A novel metalloproteinase-derived cryptide from Bothrops cotiara venom inhibits angiotensin-converting enzyme activity
Authors: Jackson Gabriel Miyamoto, Eduardo Shigueo Kitano, André Zelanis, Pedro Gabriel Nachtigall, Inácio Junqueira-de-Azevedo, Sávio Stefanini Sant'Anna, Rogério Lauria da Silva, Patrícia Alessandra Bersanetti, Adriana Karaoglanovic Carmona, Pedro José Barbosa Pereira, Solange M T Serrano, Maria Luiza Vilela Oliva, Alexandre Keiji Tashima
Journal: Biochimie
PubMed ID: 37839625
Doi: 10.1016/j.biochi.2023.10.010
Products & Services: Peptide Synthesis   
Sulforaphane alleviates the meiosis defects induced by 3-nitropropionic acid in mouse oocytes
Authors: Wei-Jian Li, Xuan Zhang, Ming Shen, Hong-Lin Liu, Li-Ren Ding
Journal: Food Chem Toxicol
PubMed ID: 37783421
Doi: 10.1016/j.fct.2023.114083
Products & Services: Molecular Biology Reagents   
Discovering human cell-compatible gene therapy virus variants via optimized screening in mouse models
Authors: Moyu Dai, Ning Yang, Kai Xu, Jingwen Zhang, Xueke Li, Ying Zhang, Wei Li
Journal: Cell Prolif
PubMed ID: 37864397
Doi: 10.1111/cpr.13565
T cells Use Focal Adhesions to Pull Themselves Through Confined Environments
Authors: Alexia Caillier, David Oleksyn, Deborah J Fowell, Jim Miller, Patrick W Oakes
Journal: biorxiv
PubMed ID: 37904911
Doi: 10.1101/2023.10.16.562587
Development of a counterselectable system for rapid and efficient CRISPR-based genome engineering in Zymomonas mobilis
Authors: Yanli Zheng, Hongmei Fu, Jue Chen, Jie Li, Yuejie Bian, Ping Hu, Lei Lei, Yihan Liu, Jiangke Yang, Wenfang Peng
Journal: Microb Cell Fact
PubMed ID: 37833755
Doi: 10.1186/s12934-023-02217-9
Rules and mechanisms governing G protein coupling selectivity of GPCRs
Authors: Ikuo Masuho , Ryoji Kise , Pablo Gainza , Ee Von Moo , Xiaona Li , Ryosuke Tany , Hideko Wakasugi-Masuho , Bruno E Correia , Kirill A Martemyanov
Journal: Cell Rep .
PubMed ID: 37742189
Doi: 10.1016/j.celrep.2023.113173
Products & Services: Gene Synthesis   
Evaluation and comparison of immune responses induced by two Mpox mRNA vaccine candidates in mice
Authors: Xidan Yang , Congxia Hu , Xuetao Yang , Xiu Yang , Xing Hu , Xingyun Wang , Cong Liu, Yuan Yuan , Shouwen Du , Peng George Wang, Jihui Lin
Journal: J Med Virol .
PubMed ID: 37800627
Doi: 10.1002/jmv.29140
Products & Services: Peptide Synthesis   
Horizontally transferred salivary protein promotes insect feeding by suppressing ferredoxin-mediated plant defenses
Authors: Yi-Zhe Wang , Yu-Xuan Ye , Jia-Bao Lu , Xin Wang , Hai-Bin Lu , Ze-Long Zhang , Zhuang-Xin Ye , Yu-Wen Lu , Zong-Tao Sun , Jian-Ping Chen , Jun-Min Li , Chuan-Xi Zhang , Hai-Jian Huang
Journal: Mol Biol Evol .
PubMed ID: 37804524
Doi: 10.1093/molbev/msad221
Products & Services: Catalog Antibody   
Rapid characterization of anti-CRISPR proteins and optogenetically engineered variants using a versatile plasmid interference system
Authors: Guoxu Song, Chunhong Tian, Jiahui Li, Fei Zhang, Yuxin Peng, Xing Gao and Yong Tian
Journal: Nucleic Acids Research
Doi: 10.1093/nar/gkad995
Products & Services: Gene Synthesis   
Establishment and characterization of a novel indirect ELISA method based on ASFV antigenic epitope-associated recombinant protein
Authors: Jiaxin Jin , Yilin Bai , Yuanyuan Zhang , Wenlong Lu , Shuai Zhang , Xuyang Zhao , Yaning Sun , Yanan Wu , Angke Zhang , Gaiping Zhang , Aijun Sun , Guoqing Zhuang
Journal: Int J Biol Macromol .
PubMed ID: 37865977
Doi: 10.1016/j.ijbiomac.2023.127311
Products & Services: Peptide Synthesis   
Structural and functional characterization of Aedes aegypti pupal cuticle protein that controls dengue virus infection
Authors: Qingqing Huang, Edem Gavor, Nikhil Kumar Tulsian, Jingsong Fan, Qingsong Lin, Yu Keung Mok, R Manjunatha Kini, J Sivaraman
Journal: Protein Sci
PubMed ID: 37593853
Doi: 10.1002/pro.4761
Products & Services: Codon Optimization   
MpADC, an L-aspartate-α-decarboxylase, from Myzus persicae, that enables production of β-alanine with high yield by whole-cell enzymatic catalysis
Authors: Pengfu Liu, Saixue Xie, Qian Guo, Yan Chen, Junying Fan, Ashok Kumar Nadda, Xiaoluo Huang, Xiaohe Chu
Journal: Biotechnol Biofuels Bioprod
PubMed ID: 37876019
Doi: 10.1186/s13068-023-02405-0
Author Correction: Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses
Authors: Xiuyuan Ou, Ge Xu, Pei Li, Yan Liu, Fuwen Zan, Pan Liu, Jiaxin Hu, Xing Lu, Siwen Dong, Yao Zhou, Zhixia Mu, Zhiqiang Wu, Jianwei Wang, Qi Jin, Pinghuang Liu, Jian Lu, Xiangxi Wang, Zhaohui Qian
Journal: Cell Discov
PubMed ID: 37813850
Doi: 10.1038/s41421-023-00597-1
G-quadruplexes of KSHV oriLyt play important roles in promoting lytic DNA replication
Authors: Prerna Dabral, Timsy Uppal, Subhash C Verma
Journal: Microbiol Spectr
PubMed ID: 37800915
Doi: 10.1128/spectrum.05316-22
Intradermal DNA vaccine delivery using vacuum-controlled, needle-free electroporation
Authors: Alison Generotti, Ryne Contreras, Brenden Zounes, Eric Schade, Andrea Kemme, Yatish Rane, Xinggang Liu, Dustin Elwood, Katherine Schultheis, Jeremy Marston, Jay McCoy, Kate Broderick, Paul Fisher
Journal: Mol Ther Nucleic Acids
PubMed ID: 38034030
Doi: 10.1016/j.omtn.2023.102070
Products & Services: Peptide Synthesis   
Tetravalent SARS-CoV-2 S1 subunit protein vaccination elicits robust humoral and cellular immune responses in SIV-infected rhesus macaque controllers
Authors: Muhammad S Khan, Eun Kim, Quentin Le Hingrat, Adam Kleinman, Alessandro Ferrari, Jose C Sammartino, Elena Percivalle, Cuiling Xu, Shaohua Huang, Thomas W Kenniston, Irene Cassaniti, Fausto Baldanti, Ivona Pandrea, Andrea Gambotto, Cristian Apetrei
Journal: MBio
PubMed ID: 37830800
Doi: 10.1128/mbio.02070-23
Products & Services: Molecular Biology Reagents   
Cryo-EM structure of severe fever with thrombocytopenia syndrome virus
Authors: Shouwen Du, Ruchao Peng, Wang Xu, Xiaoyun Qu, Yuhang Wang, Jiamin Wang, Letian Li, Mingyao Tian, Yudong Guan, Jigang Wang, Guoqing Wang, Hao Li, Lingcong Deng, Xiaoshuang Shi, Yidan Ma, Fengting Liu, Minhua Sun, Zhengkai Wei, Ningyi Jin, Wei Liu, Jianxun Qi, Quan Liu, Ming Liao, Chang Li
Journal: Nat Commun
PubMed ID: 37816705
Doi: 10.1038/s41467-023-41804-7
Products & Services: Peptide Synthesis   
SARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition
Authors: Rachel Erickson, Chang Huang, Cameron Allen, Joanna Ireland, Gwynne Roth, Zhongcheng Zou, Jinghua Lu, Bernard A P Lafont, Nicole L Garza, Beniah Brumbaugh, Ming Zhao, Motoshi Suzuki, Lisa Olano, Joseph Brzostowski, Elizabeth R Fischer, Homer L Twigg, Reed F Johnson, Peter D Sun
Journal: Nat Commun
PubMed ID: 37821447
Doi: 10.1038/s41467-023-42140-6
Products & Services: Gene Synthesis   
Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs
Authors: Ghasidit Pornnoppadol, Layne G Bond, Michael J Lucas, Jennifer M Zupancic, Yun-Huai Kuo, Boya Zhang, Colin F Greineder, Peter M Tessier
Journal: Cell Chem Biol
PubMed ID: 37890480
Doi: 10.1016/j.chembiol.2023.09.008
Products & Services: Combinatorial DNA Libraries   
Evaluation of potential targets to enhance the sensitivity of cholangiocarcinoma cells to anticancer drugs
Authors: Paula Sanchon-Sanchez, Oscar Briz, Rocio I R Macias, Mar Abad, Anabel Sanchez-Martin, Jose J G Marin, Elisa Lozano
Journal: Biomed Pharmacother
PubMed ID: 37832404
Doi: 10.1016/j.biopha.2023.115658
Products & Services: Custom RNAi Services   
Chemoproteomic capture of RNA binding activity in living cells
Authors: Andrew J Heindel, Jeffrey W Brulet, Xiantao Wang, Michael W Founds, Adam H Libby, Dina L Bai, Michael C Lemke, David M Leace, Thurl E Harris, Markus Hafner, Ku-Lung Hsu
Journal: Nat Commun
PubMed ID: 37805600
Doi: 10.1038/s41467-023-41844-z
Products & Services: Mutant Libraries   
Investigation of Immunostimulatory Effects of IFN-γ Cytokine and CD40 Ligand Costimulatory Molecule for Development of HIV-1 Therapeutic Vaccine Candidate
Authors: Fatemeh Heidarnejad, Azam Bolhassani, Soheila Ajdary, Alireza Milani, Seyed Amir Sadeghi
Journal: Adv Biol (Weinh)
PubMed ID: 37840398
Doi: 10.1002/adbi.202300402
Products & Services: Molecular Biology Reagents   
Authentication of a lophotrochozoan adipokinetic hormone receptor in a Gastropod, Aplysia californica
Authors: Pei-San Tsai, Kelsey N Sanders, Xin Dai, David Plachetzki
Journal: Gen Comp Endocrinol
PubMed ID: 37865149
Doi: 10.1016/j.ygcen.2023.114393
Products & Services: Molecular Biology Reagents   
A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT)
Authors: Li Chen, Yikai Lu, Mengmeng Zhao, Junfang Xu, Yan Wang, Qinghua Xu, Yajuan Cao, Haipeng Liu
Journal: J Gene Med
PubMed ID: 37897251
Doi: 10.1002/jgm.3612
Folic acid alleviated oxidative stress-induced telomere attrition and inhibited apoptosis of neurocytes in old rats
Authors: Dezheng Zhou, Yue Sun, Cuixia Dong, Zehao Wang, Jing Zhao, Zhenshu Li, Guowei Huang, Wen Li
Journal: Eur J Nutr
PubMed ID: 37870657
Doi: 10.1007/s00394-023-03266-x
Products & Services: Gene Synthesis   
Antibodies elicited by Plasmodium falciparum circumsporozoite proteins lacking sequentially deleted C-terminal amino acids reveal mouse strain and epitopes specific differences
Authors: Clifford T H Hayashi, Yi Cao, Fidel Zavala, Hayk Simonyan, Colin N Young, Nirbhay Kumar
Journal: Vaccine
PubMed ID: 37827976
Doi: 10.1016/j.vaccine.2023.10.009
Products & Services: Gene Synthesis   
DETECTION OF SARS-COV-2 NEUTRALIZING ANTIBODIES IN RETROPHARYNGEAL LYMPH NODE EXUDATES OF WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FROM NEBRASKA, USA
Authors: Korakrit Poonsuk, Duan Loy, Rachael Birn, Bryan Buss, Matthew Donahue, Todd Nordeen, Kylie Sinclair, Luke Meduna, Bruce Brodersen, John Dustin Loy
Journal: J Wildl Dis
PubMed ID: 37768779
Doi: 10.7589/JWD-D-23-00005
Expression of a SAG protein with a CAP domain from Eimeria necatrix and its role in invasion and immunoprotection
Authors: Feiyan Wang, Amin Zhang, Xuelian Fan, Qianqian Feng, Zhizhi Zhang, Dandan Liu, Shijie Su, Zhaofeng Hou, Jinjun Xu, Xilong Kang, Zhiming Pan, Hunjie Hu, Jianping Tao
Journal: Vet Parasitol
PubMed ID: 37931477
Doi: 10.1016/j.vetpar.2023.110060
Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes
Authors: Wei-Xin Chin, Hao Yuin Kong, Isabelle Xin Yu Zhu, Zi Yun Teo, Regina Faruk, Regina Ching Hua Lee, Si Xian Ho, Zhen Qin Aw, Bowen Yi, Xin Jun Hou, Antson Kiat Yee Tan, Thinesshwary Yogarajah, Roland G Huber, Yu Cai, Yue Wan, Justin Jang Hann Chu
Journal: PLoS Pathog
PubMed ID: 37883598
Doi: 10.1371/journal.ppat.1011753
Products & Services: Molecular Biology Reagents   
The cell-end protein Tea4 spatially regulates hyphal branch initiation and appressorium remodeling in the blast fungus
Authors: Audra Mae Rogers, Rachel Taylor, Martin John Egan
Journal: Mol Biol Cell
PubMed ID: 37903237
Doi: 10.1091/mbc.E23-06-0214
Products & Services: PCR Cloning and Subcloning   
Differential regulation of fibronectin expression and fibrillogenesis by autocrine TGF-β1 signaling in malignant and benign mammary epithelial cells
Authors: Michael M Sofroniou, Christopher A Lemmon
Journal: Int J Biochem Cell Biol
PubMed ID: 37866655
Doi: 10.1016/j.biocel.2023.106478
Products & Services: Stable Cell Lines   
Modulating biofilm can potentiate activity of novel plastic-degrading enzymes
Authors: Sophie A Howard, Ronan R McCarthy
Journal: NPJ Biofilms Microbiomes
PubMed ID: 37788986
Doi: 10.1038/s41522-023-00440-1
Products & Services: Gene Synthesis   
Development of CRISPR/Cas9-Based Genome Editing Tools for Polyploid Yeast Cyberlindnera jadinii and Its Application in Engineering Heterologous Steroid-Producing Strains
Authors: Lishan Gu, Rongxin Zhang, Xuqian Fan, Yu Wang, Kaiyu Ma, Jingjing Jiang, Gen Li, Honglei Wang, Feiyu Fan, Xueli Zhang
Journal: ACS Synth Biol
PubMed ID: 37816156
Doi: 10.1021/acssynbio.3c00278
Products & Services: Codon Optimization   
Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Authors: Zhitao Wang, Xinhui Zhang, Xueqin Lu, Peng Peng, Huiru Wang, Shanglong Feng, Li Zhou
Journal: Hematology
PubMed ID: 37850618
Doi: 10.1080/16078454.2023.2269513
Modular multiwell viscoelastic hydrogel platform for two- and three-dimensional cell culture applications
Authors: Mackenzie L Skelton, James L Gentry, Leilani R Astrab, Joshua A Goedert, E Brynn Earl, Emily L Pham, Tanvi Bhat, Steven R Caliari
Journal: biorxiv
PubMed ID: 37873098
Doi: 10.1101/2023.10.09.561449
Tafluprost promotes axon regeneration after optic nerve crush via Zn-mTOR pathway
Authors: Siting Wu, Canying Liu, Jiahui Tang, Caiqing Wu, Qi Zhang, Zhe Liu, Jiaxu Han, Jingfei Xue, Jicheng Lin, Yuze Chen, Jinpeng Yang, Yehong Zhuo, Yiqing Li
Journal: Neuropharmacology
PubMed ID: 37832634
Doi: 10.1016/j.neuropharm.2023.109746
PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes
Authors: Binglin Zhu, Emily Fisher, Li Li, Ping Zhong, Zhen Yan, Jian Feng
Journal: Stem Cell Reports
PubMed ID: 37832540
Doi: 10.1016/j.stemcr.2023.09.012
Products & Services: Molecular Biology Reagents   
Hem25p is required for mitochondrial IPP transport in fungi
Authors: Jonathan Tai, Rachel M Guerra, Sean W Rogers, Zixiang Fang, Laura K Muehlbauer, Evgenia Shishkova, Katherine A Overmyer, Joshua J Coon, David J Pagliarini
Journal: Nat Cell Biol
PubMed ID: 37813972
Doi: 10.1038/s41556-023-01250-5
Products & Services: Codon Optimization   
Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes
Authors: Alexandra Unapanta , Farbod Shavarebi , Jacob Porath , Yiyi Shen , Carson Balen , Albert Nguyen , Josh Tseng , Weng Si Leong , Michelle Liu , Pawel Lis , Santiago M Di Pietro , Annie Hiniker
Journal: J Biol Chem .
PubMed ID: 37625589
Doi: 10.1016/j.jbc.2023.105192
A two-arm analysis of the immune response to heterologous boosting of inactivated SARS-CoV-2 vaccines
Authors: Arnone Nithichanon, Ludthawun Kamuthachad, Kanin Salao, Wisitsak Phoksawat, Chatcharin Kamsom, Surasakdi Wongratanacheewin, Chonlatip Pipattanaboon, Sakawrat Kanthawong, Umaporn Yordpratum, Sirinart Aromseree, Atibordee Meesing, Piroon Mootsikapun, Steven W Edwards, Supranee Phanthanawiboon
Journal: Sci Rep
PubMed ID: 37907584
Doi: 10.1038/s41598-023-46053-8
Products & Services: Molecular Biology Reagents   
Improved Stability and Manufacturability of Nucleocapsid Antigens for SARS-CoV2 Diagnostics through Protein Engineering
Authors: Esha Shukla, Lipsa Choudhury, Saurabh Rastogi, Arshmeet Chawla, Sanghati Bhattacharya, Umesh Kaushik, Manan Mittal, Anurag Singh Rathore, Gaurav Pandey
Journal: Biomolecules
PubMed ID: 37892206
Doi: 10.3390/biom13101524
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Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control
Authors: Ryan D Mouery, Carolyn Hsu, Thomas Bonacci, Derek L Bolhuis, Xianxi Wang, Christine A Mills, E Drew Toomer, Owen G Canterbury, Kevin C Robertson, Timothy B Branigan, Nicholas G Brown, Laura E Herring, Michael J Emanuele
Journal: biorxiv
PubMed ID: 37873169
Doi: 10.1101/2023.10.11.561963
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Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis‑induced cardiomyopathy
Authors: Xin Lin, Xiaoxia Zhao, Qingfeng Chen, Xiaoyue Wang, Yongya Wu, Hao Zhao
Journal: Int J Mol Med
PubMed ID: 37859612
Doi: 10.3892/ijmm.2023.5319
Specific Nucleotides in the Common Region of the Begomovirus Tomato Rugose Mosaic Virus (ToRMV) Are Responsible for the Negative Interference over Tomato Severe Rugose Virus (ToSRV) in Mixed Infection
Authors: Angélica M Nogueira, Tarsiane M C Barbosa, Ayane F F Quadros, Anelise F Orílio, Marcela C J Bigão, César A D Xavier, Camila G Ferro, Francisco Murilo Zerbini
Journal: Viruses
PubMed ID: 37896851
Doi: 10.3390/v15102074
Products & Services: Recombinant Proteins   
Lactate promotes intracellular replication and systemic infection via driving macrophage M2 polarization
Authors: Xinyue Wang, Bin Yang, Shuangshuang Ma, Xiaolin Yan, Shuai Ma, Hongmin Sun, Yuyang Sun, Lingyan Jiang
Journal: Microbiol Spectr
PubMed ID: 37796020
Doi: 10.1128/spectrum.02253-23
Products & Services: PCR Cloning and Subcloning   
Identification and production of novel potential pathogen-specific biomarkers for diagnosis of histoplasmosis
Authors: Juan David Puerta-Arias, Juan Pablo Isaza Agudelo, Tonny Williams Naranjo Preciado
Journal: Microbiol Spectr
PubMed ID: 37882565
Doi: 10.1128/spectrum.00939-23
Products & Services: Recombinant Proteins   
Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute
Authors: Xiaopan Gao, Kun Shang, Kaixiang Zhu, Linyue Wang, Zhixia Mu, Xingke Fu, Xia Yu, Bo Qin, Hongtao Zhu, Wei Ding, Sheng Cui
Journal: Nature
Doi: doi.org/10.1038/s41586-023-06665-6
Products & Services: Gene Synthesis   
Examining the Potential Formation of Ternary DNA Complexes with Chromium‑Cysteine, Chromium-Ascorbate, and Chromium-Glutathione and Implications for Their Carcinogenicity
Authors: Sydney Marchi , Emma Lankford , Bradley Dorin , Eilidh Drummond , Sumner C Thomas , Stephen A Woski , John B Vincent
Journal: Biol Trace Elem Res .
PubMed ID: 36662348
Doi: 10.1007/s12011-023-03573-8
Products & Services: Custom DNA/RNA Oligos   
Molecular basis of methyl-salicylate-mediated plant airborne defence
Authors: Qian Gong , Yunjing Wang , Linfang He , Fan Huang , Danfeng Zhang , Yan Wang , Xiang Wei , Meng Han , Haiteng Deng , Lan Luo , Feng Cui , Yiguo Hong, Yule Liu
Journal: Nature .
PubMed ID: 37704724
Doi: 10.1038/s41586-023-06533-3
Are Histidine Kinases of Arbuscular Mycorrhizal Fungi Involved in the Response to Ethylene and Cytokinins?
Authors: Ayla Mongès, Hajar Yaakoub, Baptiste Bidon, Gaëlle Glévarec, François Héricourt, Sabine Carpin, Lucie Chauderon, Lenka Drašarová, Lukáš Spíchal, Brad M Binder, Nicolas Papon, Soizic Rochange
Journal: Mol Plant Microbe Interact .
PubMed ID: 37851914
Doi: 10.1094/MPMI-05-23-0056-R
Products & Services: Gene Synthesis   
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels
Authors: Jian Zhou, Claudia Cattoglio, Yingyao Shao, Harini P Tirumala, Carlo Vetralla, Sameer S Bajikar, Yan Li, Hu Chen, Qi Wang, Zhenyu Wu, Bing Tang, Mahla Zahabiyon, Aleksandar Bajic, Xiangling Meng, Jack J Ferrie, Anel LaGrone, Ping Zhang, Jean J Kim, Jianrong Tang, Zhandong Liu, Xavier Darzacq, Nathaniel Heintz, Robert Tjian, Huda Y Zoghbi
Journal: Genes Dev
PubMed ID: 37890975
Doi: 10.1101/gad.350733.123
A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of to metal restriction
Authors: Joy R Paterson, Joshua M Wadsworth, Ping Hu, Gary J Sharples
Journal: Microb Genom
PubMed ID: 38054971
Doi: 10.1099/mgen.0.001153
Overexpressing CsPSY1 Gene of Tea Plant, Encoding a Phytoene Synthase, Improves α-Carotene and β-Carotene Contents in Carrot
Authors: Jing-Wen Li, Ping Zhou, Yuan-Jie Deng, Zhi-Hang Hu, Xing-Hui Li, Xuan Chen, Ai-Sheng Xiong, Jing Zhuang
Journal: Mol Biotechnol
PubMed ID: 37897587
Doi: 10.1007/s12033-023-00942-5
Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence
Authors: Sunita Gulati, Andreas Holm Mattsson, Sophie Schussek, Bo Zheng, Rosane B DeOliveira, Jutamas Shaughnessy, Lisa A Lewis, Peter A Rice, Pär Comstedt, Sanjay Ram
Journal: MBio
PubMed ID: 37905891
Doi: 10.1128/mbio.02500-23
Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer
Authors: Giuditta Guerrini, Dora Mehn, Francesco Fumagalli, Sabrina Gioria, Mattia Pedotti, Luca Simonelli, Filippo Bianchini, Davide F Robbiani, Luca Varani, Luigi Calzolai
Journal: Int J Mol Sci
PubMed ID: 37834322
Doi: 10.3390/ijms241914875
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Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics
Authors: Katarzyna Pustelny, Przemyslaw Grygier, Agata Barzowska, Barbara Pucelik, Alex Matsuda, Krzysztof Mrowiec, Emilia Slugocka, Grzegorz M Popowicz, Grzegorz Dubin, Anna Czarna
Journal: Sci Rep
PubMed ID: 37872245
Doi: 10.1038/s41598-023-44810-3
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β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
Authors: Carole Daly, Akim Abdul Guseinov, Hyunggu Hahn, Adam Wright, Irina G Tikhonova, Alex Rojas Bie Thomsen, Bianca Plouffe
Journal: Elife
PubMed ID: 37855711
Doi: 10.7554/eLife.87754
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Whole-genome sequence and mass spectrometry study of the snow blight fungus Phacidium infestans (Karsten) DSM 5139 growing at freezing temperatures
Authors: C Zerouki, K Chakraborty, S Kuittinen, A Pappinen, O Turunen
Journal: Mol Genet Genomics
PubMed ID: 37815644
Doi: 10.1007/s00438-023-02073-7
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Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina
Authors: Heonuk Jeong, Deokho Lee, Xiaoyan Jiang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Journal: Sci Rep
PubMed ID: 37857760
Doi: 10.1038/s41598-023-44983-x
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Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease
Authors: Takashi Kei Kishimoto, Max Fournier, Alicia Michaud, Gina Rizzo, Christopher Roy, Teresa Capela, Natasha Nukolova, Ning Li, Liam Doyle, Fen-Ni Fu, Derek VanDyke, Peter G Traber, Jamie B Spangler, Sheldon S Leung, Petr O Ilyinskii
Journal: J Autoimmun
PubMed ID: 37844543
Doi: 10.1016/j.jaut.2023.103125
Nucleic acid-triggered NADase activation of a short prokaryotic Argonaute
Authors: Xiaopan Gao , Kun Shang , Kaixiang Zhu , Linyue Wang , Zhixia Mu , Xingke Fu , Xia Yu , Bo Qin , Hongtao Zhu , Wei Ding , Sheng Cui
Journal: Nature .
PubMed ID: 37783228
Doi: 10.1038/s41586-023-06665-6
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Plant-Based Meat Analogues Weaken Gastrointestinal Digestive Function and Show Less Digestibility Than Real Meat in Mice
Authors: Yunting Xie , Linlin Cai , Zhiji Huang , Kai Shan , Xinglian Xu , Guanghong Zhou , Chunbao Li
Journal: J Agric Food Chem .
PubMed ID: 36070521
Doi: 10.1021/acs.jafc.2c04246
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Single Amino Acid Mutation Decouples Photochemistry of the BLUF Domain from the Enzymatic Function of OaPAC and Drives the Enzyme to a Switched-on State
Authors: Jinnette Tolentino Collado, Emoke Bodis, Jonatan Pasitka, Mihaly Szucs, Zsuzsanna Fekete, Nikolett Kis-Bicskei, Elek Telek, Kinga Pozsonyi, Sofia M Kapetanaki, Greg Greetham, Peter J Tonge, Stephen R Meech, Andras Lukacs
Journal: J Mol Biol
PubMed ID: 37827329
Doi: 10.1016/j.jmb.2023.168312
Rational Design of Taxadiene Hydroxylase by Ancestral Enzyme Construction and the Elucidation of Key Amino Acids
Authors: Zihan Zhang, Longhao Huang, Zhi-Jun Zhang, Jian-He Xu, Hui-Lei Yu
Journal: Biochemistry
PubMed ID: 37902563
Doi: 10.1021/acs.biochem.3c00411
FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design
Authors: Wern Hann Ng, Xiang Liu, Zheng L Ling, Camilla N O Santos, Lucas S Magalhães, Andrew J Kueh, Marco J Herold, Adam Taylor, Joseph R Freitas, Sandra Koit, Sainan Wang, Andrew R Lloyd, Mauro M Teixeira, Andres Merits, Roque P Almeida, Nicholas J C King, Suresh Mahalingam
Journal: Nat Commun
PubMed ID: 37884534
Doi: 10.1038/s41467-023-42330-2
Biochemical and biophysical properties of a rare TTRA81V mutation causing mild transthyretin amyloid cardiomyopathy
Authors: Qiuyan Sha, Yanli Zhang, Mengdie Wang, Jialu Sun, Yunlong Zhang, Xinxin Zhang, Ning Wang, Yu Liu, Ying Liu
Journal: ESC Heart Fail
PubMed ID: 37827496
Doi: 10.1002/ehf2.14543
ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1
Authors: Karin Enell Smith, Sara Fritzell, Anneli Nilsson, Karin Barchan, Anna Rosén, Lena Schultz, Laura Varas, Anna Säll, Nadia Rose, Maria Håkansson, Laura von Schantz, Peter Ellmark
Journal: Cancer Immunol Immunother
PubMed ID: 37796298
Doi: 10.1007/s00262-023-03548-7
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Industry updates from the field of stem cell research and regenerative medicine in August 2023
Authors: Dusko Ilic, Mirjana Liovic
Journal: Regen Med
PubMed ID: 37786963
Doi: 10.2217/rme-2023-0181
Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates
Authors: Payton A-B Weidenbacher, Mrinmoy Sanyal, Natalia Friedland, Shaogeng Tang, Prabhu S Arunachalam, Mengyun Hu, Ozan S Kumru, Mary Kate Morris, Jane Fontenot, Lisa Shirreff, Jonathan Do, Ya-Chen Cheng, Gayathri Vasudevan, Mark B Feinberg, Francois J Villinger, Carl Hanson, Sangeeta B Joshi, David B Volkin, Bali Pulendran, Peter S Kim
Journal: Nat Commun
PubMed ID: 37798288
Doi: 10.1038/s41467-023-42061-4
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LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway
Authors: Kai-Jie He, Jin-Bao Zhang, Jun-Yi Liu, Feng-Lun Zhao, Xiao-Yu Yao, Yu-Ting Tang, Jin-Ru Zhang, Xiao-Yu Cheng, Li-Fang Hu, Fen Wang, Chun-Feng Liu
Journal: iScience
PubMed ID: 37876795
Doi: 10.1016/j.isci.2023.108130
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Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion
Authors: James S Foster, Manasi Balachandran, Trevor J Hancock, Emily B Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D Williams, Joseph W Jackson, Stephen J Kennel, Jonathan S Wall
Journal: Front Immunol
PubMed ID: 37854603
Doi: 10.3389/fimmu.2023.1275372
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Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2
Authors: Rodrigo Lázaro-Gorines, Patricia Pérez, Ignacio Heras-Murillo, Irene Adán-Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L Harwood, Alejandro Segura-Tudela, Laura Rubio-Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A Adipietro, Dinendra L Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D MacKerell, Laura Sanz, David J Weber, Francisco J Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy-Ruiz, Inés G Muñoz, Rafael Delgado, David Sancho, Juan García-Arriaza, Luis Álvarez-Vallina
Journal: Adv Sci (Weinh)
PubMed ID: 37863812
Doi: 10.1002/advs.202304818
Selection, activity, and nuclease stabilization of cross-neutralizing DNA aptamers targeting HSV-1 and HSV-2
Authors: Michael D Schump, David I Bernstein, Fernando J Bravo, Charles P Neff
Journal: Virology
PubMed ID: 37925791
Doi: 10.1016/j.virol.2023.109916
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Aptabinding of tumor necrosis factor-α (TNFα) inhibits its proinflammatory effects and alleviates islet inflammation
Authors: Roaa Mahmoud, Jagan Kalivarathan, Abdul J Castillo, Sasha Wang, Brian Fuglestad, Mazhar A Kanak, Soma Dhakal
Journal: Biotechnol J
PubMed ID: 37772688
Doi: 10.1002/biot.202300374
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GhL1L1 regulates the contents of unsaturated fatty acids by activating the expression of GhFAD2 genes in cotton
Authors: Dandan Yue, Xuyang Hao, Bei Han, Jiao Xu, Weinan Sun, Xiaoping Guo, Xianlong Zhang, Xiyan Yang
Journal: Gene
PubMed ID: 37839764
Doi: 10.1016/j.gene.2023.147899
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A newly identified ferritin L-subunit variant results in increased proteasomal subunit degradation, impaired complex assembly, and severe hypoferritinemia
Authors: Dayana Shagidov, Noga Guttmann-Raviv, Séverine Cunat, Liora Frech, Muriel Giansily-Blaizot, Niraj Ghatpande, Gili Abelya, Gabriel A Frank, Patricia Aguilar Martinez, Esther G Meyron-Holtz
Journal: Am J Hematol
PubMed ID: 37867341
Doi: 10.1002/ajh.27124
Characterization of a thermostable Cas12a ortholog
Authors: Jing Wu, Pan Gao, Yajing Shi, Caixiang Zhang, Xiaohan Tong, Huidi Fan, Xi Zhou, Ying Zhang, Hao Yin
Journal: Cell Insight
PubMed ID: 38047138
Doi: 10.1016/j.cellin.2023.100126
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A circRNA therapy based on Rnf103 to inhibit Vibrio anguillarum infection
Authors: Weiwei Zheng, Xing Lv, Yaqi Tao, Yanqiu Cui, Xiangxiang Zhu, Tongtong Zhu, Tianjun Xu
Journal: Cell Rep
PubMed ID: 37874674
Doi: 10.1016/j.celrep.2023.113314
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Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens
Authors: Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma
Journal: Poult Sci
PubMed ID: 37984004
Doi: 10.1016/j.psj.2023.103251
Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution
Authors: Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, Stefania Brocca
Journal: Int J Biol Macromol
PubMed ID: 38287572
Doi: 10.1016/j.ijbiomac.2023.127754
Unfolding of an RNA G-quadruplex motif in the negative strand genome of porcine reproductive and respiratory syndrome virus by host and viral helicases to promote viral replication
Authors: Puxian Fang, Congbao Xie, Ting Pan, Ting Cheng, Wei Chen, Sijin Xia, Tong Ding, Junkang Fang, Yanrong Zhou, Liurong Fang, Dengguo Wei, Shaobo Xiao
Journal: Nucleic Acids Res
PubMed ID: 37739415
Doi: 10.1093/nar/gkad759
Histone Abundance Quantification via Flow Cytometry of Htb2-GFP Allows Easy Monitoring of Cell Cycle Perturbations in Living Yeast Cells, Comparable to Standard DNA Staining
Authors: Maria V Kulakova, Eslam S M O Ghazy, Fedor Ryabov, Yaroslav M Stanishevskiy, Michael O Agaphonov, Alexander I Alexandrov
Journal: J Fungi (Basel)
PubMed ID: 37888289
Doi: 10.3390/jof9101033
A spacer design strategy for CRISPR-Cas12f1 with single-nucleotide polymorphism mutation resolution capability and its application in the mutations diagnosis of pathogens
Authors: Panqi Gao, Maoyi Yang, Yi Chen, Jun Yan, Miaomiao Han, Haijun Deng, Keli Qian, Jiandong Yang, Yaoqin Lu, Ling Zhou, Ailong Huang, Xiaosong Li, Wanyan Deng, Quanxin Long
Journal: J Med Virol
PubMed ID: 37855689
Doi: 10.1002/jmv.29189
STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1
Authors: Deli Song, Xudong Jia, Yuanzhu Gao, Tong Xiao, Jia Dan, Runling Shen, Jing Cai, Jiankai Liang, Wenbo Zhu, Jun Hu, Guangmei Yan, Qinfen Zhang, Yuan Lin
Journal: Oncogene
PubMed ID: 37864032
Doi: 10.1038/s41388-023-02872-7
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Improved prime editing allows for routine predictable gene editing in Physcomitrium patens
Authors: Pierre-François Perroud, Anouchka Guyon-Debast, Josep M Casacuberta, Wyatt Paul, Jean-Philippe Pichon, David Comeau, Fabien Nogué
Journal: J Exp Bot
PubMed ID: 37243510
Doi: 10.1093/jxb/erad189
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The Functional Characteristics and Soluble Expression of Saffron CCD2
Authors: Ying Wang, Siqi Li, Ze Zhou, Lifen Sun, Jing Sun, Chuanpu Shen, Ranran Gao, Jingyuan Song, Xiangdong Pu
Journal: Int J Mol Sci
PubMed ID: 37894770
Doi: 10.3390/ijms242015090
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A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells
Authors: Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, Haiming Huang
Journal: Front Immunol
PubMed ID: 37954614
Doi: 10.3389/fimmu.2023.1292839
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Therapeutic effect of exosomes derived from hepatocyte-growth-factor-overexpressing adipose mesenchymal stem cells on liver injury
Authors: Liushenyan Yu, Junchao Xue, Yanyan Wu, Hanyu Zhou
Journal: Folia Histochem Cytobiol
PubMed ID: 37787035
Doi: 10.5603/fhc.95291
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