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A Polyvalent Adhesin-Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Adhesins (CS7, CS12, CS14, CS17, and CS21) but Not Enterotoxins (LT and STa)

Authors: Siqi Li, Hyesuk Seo, Ipshita Upadhyay, Weiping Zhang

Journal: Microorganisms

PubMed ID: 37894131

Doi: 10.3390/microorganisms11102473

Products & Services: Gene Synthesis

Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19

Authors: Gang Ye, Ruangang Pan, Fan Bu, Jian Zheng, Alise Mendoza, Wei Wen, Lanying Du, Benjamin Spiller, Brian E Wadzinski, Bin Liu, Stanley Perlman, Fang Li

Journal: J Virol

PubMed ID: 37855638

Doi: 10.1128/jvi.01448-23

Products & Services: Plasmids for SARS-CoV-2 Detection and Research

Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis

Authors: Alžběta Motyčková, Luboš Voleman, Vladimíra Najdrová, Lenka Arbonová, Martin Benda, Vít Dohnálek, Natalia Janowicz, Ronald Malych, Róbert Šuťák, Thijs J G Ettema, Staffan Svärd, Courtney W Stairs, Pavel Doležal

Journal: PLoS Pathog

PubMed ID: 37792908

Doi: 10.1371/journal.ppat.1010773

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular insights into the HLA-B35 molecules' classification associated with HIV control

Authors: Christian A Lobos, Demetra Sm Chatzileontiadou, Bonin Sok, Coral-Ann Almedia, Hanim Halim, Lloyd D'Orsogna, Stephanie Gras

Journal: Immunol Cell Biol

PubMed ID: 37811811

Doi: 10.1111/imcb.12698

Products & Services: Peptide Synthesis

The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection

Authors: Déborah Lécuyer, Roberta Nardacci, Désirée Tannous, Emie Gutierrez-Mateyron, Aurélia Deva Nathan, Frédéric Subra, Cristina Di Primio, Paola Quaranta, Vanessa Petit, Clémence Richetta, Ali Mostefa-Kara, Franca Del Nonno, Laura Falasca, Romain Marlin, Pauline Maisonnasse, Julia Delahousse, Juliette Pascaud, Eric Deprez, Marie Naigeon, Nathalie Chaput, Angelo Paci, Véronique Saada, David Ghez, Xavier Mariette, Mario Costa, Mauro Pistello, Awatef Allouch, Olivier Delelis, Mauro Piacentini, Roger Le Grand, Jean-Luc Perfettini

Journal: Front Immunol

PubMed ID: 37920468

Doi: 10.3389/fimmu.2023.1270081

Products & Services: Proteins, Expression, Isolation and Analysis

A novel recombinant S-based subunit vaccine induces protective immunity against porcine deltacoronavirus challenge in piglets

Authors: Jizong Li, Shuqing Zhao, Baotai Zhang, Jin Huang, Qi Peng, Li Xiao, Xuesong Yuan, Rongli Guo, Jinzhu Zhou, Baochao Fan, Tao Xue, Xuejiao Zhu, Chuanmin Liu, Xing Zhu, Lili Ren, Bin Li

Journal: J Virol

PubMed ID: 37846983

Doi: 10.1128/jvi.00958-23

Products & Services: Proteins, Expression, Isolation and Analysis

Diversity of rhodopsin cyclases in zoospore-forming fungi

Authors: Matthias Broser, Wayne Busse, Anika Spreen, Maila Reh, Yinth Andrea Bernal Sierra, Songhwan Hwang, Tillmann Utesch, Han Sun, Peter Hegemann

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37871207

Doi: 10.1073/pnas.2310600120

Products & Services: Gene Synthesis

Construction and functional verification of size-reduced plasmids based on TMP resistance gene

Authors: Chun-Cao Li, Rui Hu, Xiu-Min Hua, Yi-Xuan Ni, Lu Ge, Lu Zhang, Wen Yu, Ni-Xin Hao, Hui Xia, Qiang Fang, Zhi-Yong Tao

Journal: Microbiol Spectr

PubMed ID: 37905802

Doi: 10.1128/spectrum.01206-23

Products & Services: Plasmid DNA Preparation

Structural and dynamical changes of the Streptococcus gordonii metalloregulatory ScaR protein induced by Mn ion binding

Authors: Katarina Radman, Zoe Jelić Matošević, Dijana Žilić, Ivo Crnolatac, Nikola Bregović, Marina Kveder, Ivo Piantanida, Pedro A Fernandes, Ivana Leščić Ašler, Branimir Bertoša

Journal: Int J Biol Macromol

PubMed ID: 37866578

Doi: 10.1016/j.ijbiomac.2023.127572

Products & Services: Proteins, Expression, Isolation and Analysis

Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes

Authors: Madeeha Ghazi, Shivangi Khanna, Yogaspoorthi Subramaniam, Jeyashri Rengaraju, Farina Sultan, Iti Gupta, Kanupriya Sharma, Sudhir Chandna, Rajesh S Gokhale, Vivek T Natarajan

Journal: Nucleic Acids Res

PubMed ID: 37697436

Doi: 10.1093/nar/gkad704

Products & Services: Polyclonal Antibody Services

Dual immunization with CdtB protein and flagellin epitope offers augmented protection against enteric fever in mice

Authors: Shania Vij, Reena Thakur, Raghwendra Pratap Singh, Rashmi Kumar, Preeti Pathania, Varsha Gupta, Chander Raman Suri, Praveen Rishi

Journal: Life Sci

PubMed ID: 37918629

Doi: 10.1016/j.lfs.2023.122216

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Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time- Resolved Monitoring of Substrate Ubiquitination in Live Cells

Authors: Lu-Jun Liang, Yu Wang, Xiao Hua, Rujing Yuan, Qiong Xia, Rongtian Wang, Chuntong Li, Guo-Chao Chu, Lei Liu, and Yi-Ming Li

Journal: JACS Au

Doi: 10.1021/jacsau.3c00421

Products & Services: Gene Synthesis

A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering

Authors: Zhiheng Yang , Zilong Li , Bixiao Li , Ruihong Bu , Gao-Yi Tan , Zhengduo Wang , Hao Yan , Zhenguo Xin , Guojian Zhang , Ming Li , Hua Xiang, Lixin Zhang , Weishan Wang

Journal: Nat Commun .

PubMed ID: 37794017

Doi: 10.1038/s41467-023-41973-5

Products & Services: Custom DNA/RNA Oligos CRISPR Libraries

Histone Abundance Quantification via Flow Cytometry of Htb2-GFP Allows Easy Monitoring of Cell Cycle Perturbations in Living Yeast Cells, Comparable to Standard DNA Staining

Authors: Maria V Kulakova, Eslam S M O Ghazy, Fedor Ryabov, Yaroslav M Stanishevskiy, Michael O Agaphonov, Alexander I Alexandrov

Journal: J Fungi (Basel)

PubMed ID: 37888289

Doi: 10.3390/jof9101033

Products & Services: Proteins, Expression, Isolation and Analysis

Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

Authors: Rajesh P Ringe, Philippe Colin, Gabriel Ozorowski, Joel D Allen, Anila Yasmeen, Gemma E Seabright, Jeong Hyun Lee, Aleksandar Antanasijevic, Kimmo Rantalainen, Thomas Ketas, John P Moore, Andrew B Ward, Max Crispin, P J Klasse

Journal: PLoS Pathog

PubMed ID: 37903160

Doi: 10.1371/journal.ppat.1011601

Products & Services: Proteins, Expression, Isolation and Analysis

VP2 residue N142 of coxsackievirus A10 is critical for the interaction with KREMEN1 receptor and neutralizing antibodies and the pathogenicity in mice

Authors: Xue Li, Zeyu Liu, Xingyu Yan, Yuan Tian, Kexin Liu, Yue Zhao, Jiang Shao, Pei Hao, Chao Zhang

Journal: PLoS Pathog

PubMed ID: 37788227

Doi: 10.1371/journal.ppat.1011662

Products & Services: Proteins, Expression, Isolation and Analysis

One ring closer to a closure: the crystal structure of the ES hydroxymethylbilane synthase intermediate

Authors: Helene J Bustad, Marthe S Christie, Mikko Laitaoja, Aasne K Aarsand, Aurora Martinez, Janne Jänis, Juha P Kallio

Journal: FEBS J

PubMed ID: 37863644

Doi: 10.1111/febs.16982

Products & Services: Proteins, Expression, Isolation and Analysis

Improved prime editing allows for routine predictable gene editing in Physcomitrium patens

Authors: Pierre-François Perroud, Anouchka Guyon-Debast, Josep M Casacuberta, Wyatt Paul, Jean-Philippe Pichon, David Comeau, Fabien Nogué

Journal: J Exp Bot

PubMed ID: 37243510

Doi: 10.1093/jxb/erad189

Products & Services: Molecular Biology Reagents

The Functional Characteristics and Soluble Expression of Saffron CCD2

Authors: Ying Wang, Siqi Li, Ze Zhou, Lifen Sun, Jing Sun, Chuanpu Shen, Ranran Gao, Jingyuan Song, Xiangdong Pu

Journal: Int J Mol Sci

PubMed ID: 37894770

Doi: 10.3390/ijms242015090

Products & Services: Gene Synthesis

Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells

Authors: Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim

Journal: Nature

PubMed ID: 37880368

Doi: 10.1038/s41586-023-06676-3

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A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

Authors: Lounis Yakhou, Anaelle Azogui, Nikhil Gupta, Julien Richard Albert, Fumihito Miura, Laure Ferry, Kosuke Yamaguchi, Sarah Battault, Pierre Therizols, Frédéric Bonhomme, Elouan Bethuel, Arpita Sarkar, Maxim V C Greenberg, Paola B Arimondo, Gael Cristofari, Olivier Kirsh, Takashi Ito, Pierre-Antoine Defossez

Journal: Nucleic Acids Res

PubMed ID: 37650637

Doi: 10.1093/nar/gkad719

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A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells

Authors: Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, Haiming Huang

Journal: Front Immunol

PubMed ID: 37954614

Doi: 10.3389/fimmu.2023.1292839

Products & Services: Monoclonal Antibody Services

Varying the expression pattern of the strigolactone receptor gene results in phenotypes distinct from both wild type and knockout mutants

Authors: Revel S M Drummond, Hui Wen Lee, Zhiwei Luo, Jack F Dakin, Bart J Janssen, Kimberley C Snowden

Journal: Front Plant Sci

PubMed ID: 37900765

Doi: 10.3389/fpls.2023.1277617

Products & Services: Combinatorial DNA Libraries

Structure-function relationships in ShKT domain peptides: ShKT-Ts1 from the sea anemone Telmatactis stephensoni

Authors: Karoline Sanches, Lauren M Ashwood, Abisola Ave-Maria Olushola-Siedoks, Dorothy C C Wai, Arfatur Rahman, Kashmala Shakeel, Muhammad Umair Naseem, Gyorgy Panyi, Peter J Prentis, Raymond S Norton

Journal: Proteins

PubMed ID: 37794633

Doi: 10.1002/prot.26594

Products & Services: Molecular Biology Reagents

Electroacupuncture at GB20 improves cognitive ability and synaptic plasticity via the CaM-CaMKII-CREB signaling pathway following cerebral ischemia-reperfusion injury in rats

Authors: Qing Han, Feng Wang

Journal: Acupunct Med

PubMed ID: 38126262

Doi: 10.1177/09645284231202805

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Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis

Authors: Wei Zhang, Zhuo Wan, Di Qu, Wenqi Sun, Liang Zhang, Yuan Liang, Lei Pan, Hua Jiang, Zichen Ye, Mengying Wei, Lijun Yuan, Guodong Yang, Faguang Jin

Journal: Bioact Mater

PubMed ID: 37965241

Doi: 10.1016/j.bioactmat.2023.09.019

Products & Services: Gene Synthesis

miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells

Authors: Qihui Jia, Yuzhu Cao, Mengmeng Zhang, Yuxin Xing, Tian Xia, Yulong Guo, Yaxin Yue, Xin Li, Xiaojun Liu, Yanhua Zhang, Donghua Li, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Hong Li

Journal: Poult Sci

PubMed ID: 37939591

Doi: 10.1016/j.psj.2023.103200

Products & Services: Proteins, Expression, Isolation and Analysis

Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness

Authors: Shengmiao Chen, Yiran Wu, Yang Gao, Chenxu Wu, Yuetong Wang, Chun Hou, Miao Ren, Shuyuan Zhang, Qi Zhu, Jiali Zhang, Yufeng Yao, Mei Huang, Yingchuan B Qi, Xue-Song Liu, Tiffany Horng, Haopeng Wang, Dan Ye, Zhengjiang Zhu, Suwen Zhao, Gaofeng Fan

Journal: Cell Rep

PubMed ID: 37831605

Doi: 10.1016/j.celrep.2023.113246

Products & Services: Molecular Biology Reagents

Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis

Authors: Mengmeng Liang, Ke Wang, Xiaoyu Wei, Xiaoshan Gong, Hao Tang, Hao Xue, Jing Wang, Pengbin Yin, Licheng Zhang, Zaisong Ma, Ce Dou, Shiwu Dong, Jianzhong Xu, Fei Luo, Qinyu Ma

Journal: Cell Rep Med

PubMed ID: 37852176

Doi: 10.1016/j.xcrm.2023.101228

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Inherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein

Authors: Norio Motohashi, Katsura Minegishi, Yoshitsugu Aoki

Journal: Cell Death Dis

PubMed ID: 37857600

Doi: 10.1038/s41419-023-06192-2

Products & Services: DNA Sequencing

Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma

Authors: Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang, Tingting Zhao, Shihui Zhang, Yong Lin, Hongzhou Zhao, Yongpan Liu, Yuxuan Wei, Yijian Zhou, Jiaying Zhang, Xianzong Ye, Jing Zhao, Xinxin Li, Jianwen Que, Songlin Shi, Kuancan Liu

Journal: Cell Death Discov

PubMed ID: 37891174

Doi: 10.1038/s41420-023-01693-7

Products & Services: Molecular Biology Reagents

Acrylamide induces neurotoxicity in zebrafish (Danio rerio) via NLRP3-mediated pyroptosis

Authors: Boya Zhang, Mengyao Zhao, Xiaoguo Ji, Quanming Xia, Lihua Jiang, Liming Zhao

Journal: Science of The Total Environment

PubMed ID: 37392875

Doi: 10.1016/j.scitotenv.2023.165208

Products & Services: Polyclonal Antibody Services

ROS-scavenging anti-inflammatory nucleic acid delivery system for targeted treatment of atherosclerosis

Authors: Zunjing Liua , Zihao Liub , Yi Shanc , Chen Xub , Bingran Yub, FuJian Xub

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102005

Products & Services: Peptide Synthesis

Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion

Authors: Junwei Gao , Can Cao , Mingfei Shi , Shihao Hong , Shijie Guo , Jing Li , Tengxiao Liang , Ping Song , Ruodan Xu , Ning Li

Journal: Phytomedicine .

PubMed ID: 37421767

Doi: 10.1016/j.phymed.2023.154942

Products & Services: Peptide Synthesis Gene Synthesis

An artificially split class 3 intein

Authors: Tia M Ariagno , John S Smetana , Christopher W Lennon

Journal: MicroPubl Biol .

PubMed ID: 37811346

Doi: 10.17912/micropub.biology.000977

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Epitope editing enables targeted immunotherapy of acute myeloid leukaemia

Authors: Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed Salah Mahmoud, Iratxe Ugarte Zabala, Jing Zeng, Scott B Ficarro, Denise Klatt, Christian Brendel, Alessandro Rambaldi, Jerome Ritz , Jarrod A Marto, Danilo Pellin, Daniel E Bauer, Scott A Armstrong, Pietro Genovese

Journal: Nature

PubMed ID: 37648862

Doi: 10.1038/s41586-023-06496-5

Products & Services: Combinatorial DNA Libraries

Clinical Course, Immunogenicity, and Efficacy of BNT162b2 mRNA Vaccination Against SARS-CoV-2 Infection in Liver Transplant Recipients

Authors: Eunice X Tan, Wen Hui Lim, Elizabeth Thong, Jean-Marc Chavatte, Jinyan Zhang, Jonathan Lim, Jocelyn Y Jin, Daniel R X Lim, Jaclyn Y T Kang, Ansel Shao Pin Tang, Kai En Chan, Caitlyn Tan, Shi Ni Tan, Benjamin Nah, Daniel Q Huang, Lin-Fa Wang, Paul A Tambyah, Jyoti Somani, Barnaby Young, Mark D Muthiah

Journal: Transplant Direct

PubMed ID: 37745946

Doi: 10.1097/TXD.0000000000001537

Products & Services: Proteins, Expression, Isolation and Analysis

Ligand-displaying cells and minicells for programmable delivery of toxic payloads via type IV secretion systems

Authors: Yang Grace Li, Kouhei Kishida, Natsumi Ogawa-Kishida, Peter J Christie

Journal: MBio

PubMed ID: 37772866

Doi: 10.1128/mbio.02143-23

Products & Services: Proteins, Expression, Isolation and Analysis

Quantitative assessment of near-infrared fluorescent proteins

Authors: Hanbin Zhang, Stavrini Papadaki, Xiaoting Sun, Xinyue Wang, Mikhail Drobizhev, Luxia Yao, Michel Rehbock, Reinhard W Köster, Lianfeng Wu, Kazuhiko Namikawa, Kiryl D Piatkevich

Journal: Nat Methods

PubMed ID: 37666982

Doi: 10.1038/s41592-023-01975-z

Products & Services: Molecular Biology Reagents

Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity

Authors: Huangcan Li, Xiong Wang, Yiran Wang, Yichen Li, Ying Chen, Yin-Ting Wong, Jufang He, Ming-Liang He

Journal: Signal Transduct Target Ther

PubMed ID: 37743411

Doi: 10.1038/s41392-023-01630-1

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Characterization of nanodisc-forming peptides for membrane protein studies

Authors: Bankala Krishnarjuna, Gaurav Sharma, Sang-Choul Im, Richard Auchus, G M Anantharamaiah, Ayyalusamy Ramamoorthy

Journal: J Colloid Interface Sci

PubMed ID: 37801850

Doi: 10.1016/j.jcis.2023.09.162

Products & Services: Proteins, Expression, Isolation and Analysis

Intracellular Fusobacterium nucleatum infection attenuates antitumor immunity in esophageal squamous cell carcinoma

Authors: Yiqiu Li, Shan Xing, Fangfang Chen, Qifan Li, Shuheng Dou, Yuying Huang, Jun An, Wanli Liu, Ge Zhang

Journal: Nat Commun

PubMed ID: 37723150

Doi: 10.1038/s41467-023-40987-3

Products & Services: Molecular Biology Reagents

Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake

Authors: Rodger de Miranda, Bonnie J Cuthbert, Thaís Klevorn, Alex Chao, Jessica Mendoza, Mark Arbing, Paul J Sieminski, Kadamba Papavinasasundaram, Sumer Abdul-Hafiz, Sum Chan, Christopher M Sassetti, Sabine Ehrt, Celia W Goulding

Journal: PLoS Pathog

PubMed ID: 37747938

Doi: 10.1371/journal.ppat.1011650

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Lactiplantibacillus plantarum as a novel platform for production and purification of integral membrane proteins using RseP as the benchmark

Authors: Sofie S Kristensen, Marie V Lukassen, Suzana Siebenhaar, Dzung B Diep, J Preben Morth, Geir Mathiesen

Journal: Sci Rep

PubMed ID: 37658186

Doi: 10.1038/s41598-023-41559-7

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Ionocyte-Specific Regulation of Cystic Fibrosis Transmembrane Conductance Regulator

Authors: Yukiko Sato, Dusik Kim, Mark J Turner, Yishan Luo, Syeda Sadaf Zehra Zaidi, David Y Thomas, John W Hanrahan

Journal: Am J Respir Cell Mol Biol

PubMed ID: 36952679

Doi: 10.1165/rcmb.2022-0241OC

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Intracellular K limits T cell exhaustion and preserves antitumor function

Authors: Camille Collier, Kelly Wucherer, Matthew McWhorter, Chelsea Jenkins, Alexandra Bartlett, Rahul Roychoudhuri, Robert Eil

Journal: biorxiv

PubMed ID: 37745435

Doi: 10.1101/2023.09.13.556997

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Antibody response in patients undergoing chronic hemodialysis post-severe acute respiratory syndrome coronavirus 2 vaccination: A prospective observational study

Authors: Heejung Choi, Sungdam Han, Ji Su Kim, Bumhee Park, Min-Jeong Lee, Gyu-Tae Shin, Heungsoo Kim, Kyongmin Kim, A-Young Park, Ho-Joon Shin, Inwhee Park

Journal: Medicine (Baltimore)

PubMed ID: 37773791

Doi: 10.1097/MD.0000000000035484

Products & Services: Proteins, Expression, Isolation and Analysis

Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity

Authors: Sigrun K Maurer, Matthias P Mayer, Stephanie J Ward, Sana Boudjema, Mohamed Halawa, Jiatong Zhang, Simon G Caulton, Jonas Emsley, Ingrid Dreveny

Journal: J Biol Chem

PubMed ID: 37777157

Doi: 10.1016/j.jbc.2023.105300

Products & Services: Proteins, Expression, Isolation and Analysis

LMNB1 targets FOXD1 to promote progression of prostate cancer

Authors: Yuanshe Huang, Lai Zhang, Tianlei Liu, E Liang

Journal: Exp Ther Med

PubMed ID: 37840569

Doi: 10.3892/etm.2023.12212

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibitory effect of Eimeria maxima IFN-γ inhibitory molecules on the immune function of T cell subsets in chickens

Authors: Xianglin Pu, Yangdong Pan, Quanjia Xiang, Mingmin Lu, Lixin Xu, Ruofeng Yan, Xiangrui Li, Xiaokai Song

Journal: Poult Sci

PubMed ID: 37797491

Doi: 10.1016/j.psj.2023.103098

Products & Services: Proteins, Expression, Isolation and Analysis

ActuAtor, a Listeria-inspired molecular tool for physical manipulation of intracellular organizations through de novo actin polymerization

Authors: Hideki Nakamura, Elmer Rho, Christopher T Lee, Kie Itoh, Daqi Deng, Satoshi Watanabe, Shiva Razavi, Hideaki T Matsubayashi, Cuncheng Zhu, Eleanor Jung, Padmini Rangamani, Shigeki Watanabe, Takanari Inoue

Journal: Cell Rep

PubMed ID: 37734382

Doi: 10.1016/j.celrep.2023.113089

Products & Services: Proteins, Expression, Isolation and Analysis

Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking

Authors: Lihong Liu, Ryan G Casner, Yicheng Guo, Qian Wang, Sho Iketani, Jasper Fuk-Woo Chan, Jian Yu, Bernadeta Dadonaite, Manoj S Nair, Hiroshi Mohri, Eswar R Reddem, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kwok-Yung Yuen, Zizhang Sheng, Yaoxing Huang, Jesse D Bloom, Lawrence Shapiro, David D Ho

Journal: Immunity

PubMed ID: 37776849

Doi: 10.1016/j.immuni.2023.09.003

Products & Services: Proteins, Expression, Isolation and Analysis

Next step in the development of mesoprogestins: the preclinical profile of EC313

Authors: K Błaszczak-Świątkiewicz, A Krupa, E Mnich, W Elger, M Oettel, H Nair, M Wierzbicki, P Sieroszewski, Z Shaked

Journal: Front Endocrinol (Lausanne)

PubMed ID: 37766684

Doi: 10.3389/fendo.2023.1201547

Products & Services: Proteins, Expression, Isolation and Analysis

The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

Authors: Cameron P Gill, Christopher Phan, Vivien Platt, Danielle Worrell, Thomas Andl, Hervé Roy

Journal: Microbiol Spectr

PubMed ID: 37768052

Doi: 10.1128/spectrum.01429-23

Products & Services: Proteins, Expression, Isolation and Analysis

Single-Dose Intranasal Immunisation with Novel Chimeric H1N1 Expressing the Receptor-Binding Domain of SARS-CoV-2 Induces Robust Mucosal Immunity, Tissue-Resident Memory T Cells, and Heterologous Protection in Mice

Authors: Donghong Wang, Yao Deng, Jianfang Zhou, Wen Wang, Baoying Huang, Wenling Wang, Lan Wei, Jiao Ren, Ruiwen Han, Jialuo Bing, Chengcheng Zhai, Xiaoyan Guo, Wenjie Tan

Journal: Vaccines (Basel)

PubMed ID: 37766130

Doi: 10.3390/vaccines11091453

Products & Services: Proteins, Expression, Isolation and Analysis

A conserved N protein nano-vaccine of COVID-19 exerts potent and cross-reactive humoral and cellular immune responses in mice

Authors: Bing Li, Jing Zhang, Yang Huang, Xinrui Li, Jing Feng, Yan Li, Rongxin Zhang

Journal: J Med Virol

PubMed ID: 37750245

Doi: 10.1002/jmv.29115

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Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison

Authors: Inge Kroidl, Simon Winter, Raquel Rubio-Acero, Abhishek Bakuli, Christof Geldmacher, Tabea M Eser, Flora Déak, Sacha Horn, Anna Zielke, Mohamed I M Ahmed, Paulina Diepers, Jessica Guggenbühl, Jonathan Frese, Jan Bruger, Kerstin Puchinger, Jakob Reich, Philine Falk, Alisa Markgraf, Heike Fensterseifer, Ivana Paunovic, Angelika Thomschke, Michael Pritsch, Friedrich Riess, Elmar Saathoff, Michael Hoelscher, Laura Olbrich, Noemi Castelletti, Andreas Wieser

Journal: Virol J

PubMed ID: 37658454

Doi: 10.1186/s12985-023-02167-z

Products & Services: Proteins, Expression, Isolation and Analysis

Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours

Authors: Dan Li, Ruixue Wang, Tianyuzhou Liang, Hua Ren, Chaelee Park, Chin-Hsien Tai, Weiming Ni, Jing Zhou, Sean Mackay, Elijah Edmondson, Javed Khan, Brad St Croix, Mitchell Ho

Journal: Nat Commun

PubMed ID: 37739951

Doi: 10.1038/s41467-023-41631-w

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Ameliorative effect of Alangium chinense (Lour) Harms on rheumatoid arthritis by reducing autophagy with targeting regulate JAK3-STAT3 and COX-2 pathways

Authors: Ting Xiao, Xingyan Cheng, Yuan Zhi, Fangfang Tian, Ai Wu, Feilong Huang, Ling Tao, Zhenghong Guo, Xiangchun Shen

Journal: J Ethnopharmacol

PubMed ID: 37690476

Doi: 10.1016/j.jep.2023.117133

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Listeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection

Authors: Trevor S Anderson, Amanda L McCormick, Elizabeth A Daugherity, Mariam Oladejo, Izuchukwu F Okpalanwaka, Savanna L Smith, Duke Appiah, Laurence M Wood, Devin B Lowe

Journal: Oncoimmunology

PubMed ID: 37781234

Doi: 10.1080/2162402X.2023.2260620

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Engineering gain-of-function mutants of a WW domain by dynamics and structural analysis

Authors: Jin Lu, Mohammad Imtiazur Rahman, I Can Kazan, Nicholas R Halloran, Andrey A Bobkov, S Banu Ozkan, Giovanna Ghirlanda

Journal: Protein Sci

PubMed ID: 37574787

Doi: 10.1002/pro.4759

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An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression

Authors: Qiong Luo , Yijun Liu , Ke Shi , Xuecheng Shen , Yaqi Yang , Xuejiao Liang , Liangliang Lu , Wenxuan Qiao , Airu Chen , Dongmei Hong , Yang Sun , Qiang Xu

Journal: Immunity

PubMed ID: 37473759

Doi: 10.1016/j.immuni.2023.06.012

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PCAP-1a, an exopolysaccharide from Pectobacterium actinidiae, exerts the dual role of immunogenicity and virulence in plants

Authors: Zhixiang Yuan , Tingmi Yang , Qingping Xiong , Yuqi Shi , Xixi Han , Yuqing Lin , Njoroge Hellen Wambui , Zhuang Liu , Yunpeng Wang , Hongxia Liu

Journal: Carbohydrate Polymers

Doi: 10.1016/j.carbpol.2023.121390

Products & Services: Proteins, Expression, Isolation and Analysis

Immuno-bioinformatic approach for designing of multi-epitope merozoite surface antigen of Babesia bigemina and evaluation of its immunogenicity in inoculated calves

Authors: Z Ul Rehman, M Suleman, K Ashraf, S Ali, S Rahman, M I Rashid

Journal: Pol J Vet Sci

PubMed ID: 37727102

Doi: 10.24425/pjvs.2023.145047

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Impact of Echinococcus granulosus Antigens on Monocyte Development and Dendritic Cell Differentiation

Authors: Mingxia Wang, Fei Qiao, Zihua Li, Qiang Wang, Zailing Shang, Junhu Hei, Xuelin Ma, Yana Wang

Journal: Iran J Immunol

PubMed ID: 37458144

Doi: 10.22034/iji.2023.98163.2557

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The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2

Authors: Miao Gu, Xiaodi Li, Ronghua Wu, Xiao Cheng, Songlin Zhou, Xiaosong Gu

Journal: Mol Neurobiol

PubMed ID: 37672148

Doi: 10.1007/s12035-023-03616-0

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Development of a plant-based oral vaccine candidate against the bovine respiratory pathogen

Authors: Angelo Kaldis, Muhammed Salah Uddin, Jose Ortiz Guluarte, Coby Martin, Trevor W Alexander, Rima Menassa

Journal: Front Plant Sci

PubMed ID: 37790785

Doi: 10.3389/fpls.2023.1251046

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A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses

Authors: Sneha Vishwanath, George William Carnell, Matteo Ferrari, Benedikt Asbach, Martina Billmeier, Charlotte George, Maria Suau Sans, Angalee Nadesalingam, Chloe Qingzhou Huang, Minna Paloniemi, Hazel Stewart, Andrew Chan, David Arthur Wells, Patrick Neckermann, David Peterhoff, Sebastian Einhauser, Diego Cantoni, Martin Mayora Neto, Ingo Jordan, Volker Sandig, Paul Tonks, Nigel Temperton, Simon Frost, Katharina Sohr, Maria Teresa Lluesma Ballesteros, Farzad Arbabi, Johannes Geiger, Christian Dohmen, Christian Plank, Rebecca Kinsley, Ralf Wagner, Jonathan Luke Heeney

Journal: Nat Biomed Eng

PubMed ID: 37749309

Doi: 10.1038/s41551-023-01094-2

Products & Services: Proteins, Expression, Isolation and Analysis

A mechanism that ensures non-selective cytoplasm degradation by autophagy

Authors: Tetsuya Kotani, Yuji Sakai, Hiromi Kirisako, Chika Kakuta, Soichiro Kakuta, Yoshinori Ohsumi, Hitoshi Nakatogawa

Journal: Nat Commun

PubMed ID: 37726301

Doi: 10.1038/s41467-023-41525-x

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Host Interactions with Engineered T-cell Micropharmacies

Authors: Christopher M Bourne, Patrick Wallisch, Megan M Dacek, Thomas J Gardner, Stephanie Pierre, Kristen Vogt, Broderick C Corless, Mamadou A Bah, Jesus E Romero-Pichardo, Angel Charles, Keifer G Kurtz, Derek S Tan, David A Scheinberg

Journal: Cancer Immunol Res

PubMed ID: 37379366

Doi: 10.1158/2326-6066.CIR-22-0879

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CDK10 suppresses metastasis of lung adenocarcinoma through inhibition of the ETS2/c-Raf/p-MEK/p-ERK signaling loop

Authors: Xiujuan Zhang, Yu Zhao, Ruzetuoheti Yiminniyaze, Ning Zhu, Yuanyuan Zhang, Gulinuer Wumaier, Jingwen Xia, Liang Dong, Daibing Zhou, Jing Wang, Chengwei Li, Youzhi Zhang, Shengqing Li

Journal: Mol Carcinog

PubMed ID: 37737453

Doi: 10.1002/mc.23636

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Vaccination of cattle with the Babesia bovis sexual-stage protein HAP2 abrogates parasite transmission by Rhipicephalus microplus ticks

Authors: Marta G Silva, Reginaldo G Bastos, Jacob M Laughery, Heba F Alzan, Vignesh A Rathinasamy, Brian M Cooke, Carlos E Suarez

Journal: npj Vaccines

PubMed ID: 37758790

Doi: 10.1038/s41541-023-00741-8

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Flow cytometry analysis of protein expression using antibody-derived tags followed by CITE-Seq

Authors: Xiaoshan Shi, Wei Fan, Majid Mehrpouyan, Yu Chen, Louise M D'Cruz, Stephanie J Widmann, Aaron J Tyznik

Journal: Cytometry A

PubMed ID: 37772953

Doi: 10.1002/cyto.a.24792

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Synergism between CMG helicase and leading strand DNA polymerase at replication fork

Authors: Zhichun Xu, Jianrong Feng, Daqi Yu, Yunjing Huo, Xiaohui Ma, Wai Hei Lam, Zheng Liu, Xiang David Li, Toyotaka Ishibashi, Shangyu Dang, Yuanliang Zhai

Journal: Nat Commun

PubMed ID: 37730685

Doi: 10.1038/s41467-023-41506-0

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Asymmetric variation in DNA methylation during domestication and de-domestication of rice

Authors: Shuai Cao, Kai Chen, Kening Lu, Shiting Chen, Xiyu Zhang, Congcong Shen, Shuangbin Zhu, Yanan Niu, Longjiang Fan, Z Jeffrey Chen, Jianlong Xu, Qingxin Song

Journal: Plant Cell

PubMed ID: 37279583

Doi: 10.1093/plcell/koad160

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Development of an anti-SARS-CoV-2 monoclonal antibody panel and its applicability as a reagent in high-throughput fluorescence reduction neutralization and immunohistochemistry assays

Authors: Gabriela M Coelho, Allan H D Cataneo, Sonia M Raboni, Meri B Nogueira, Caroline B Vaz de Paula, Ana C S F Almeida, Vanessa Z Rogerio, Nilson T Zanchin, Lucia de Noronha, Camila Zanluca, Claudia N Duarte Dos Santos

Journal: J Med Virol

PubMed ID: 37750235

Doi: 10.1002/jmv.29111

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Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models

Authors: Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Pahan

Journal: J Clin Invest

PubMed ID: 37552543

Doi: 10.1172/JCI161987

Products & Services: Proteins, Expression, Isolation and Analysis

A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo

Authors: Burcu Bestas, Sandra Wimberger, Dmitrii Degtev, Alexandra Madsen, Antje K Rottner, Fredrik Karlsson, Sergey Naumenko, Megan Callahan, Julia Liz Touza, Margherita Francescatto, Carl Ivar Möller, Lukas Badertscher, Songyuan Li, Silvia Cerboni, Niklas Selfjord, Elke Ericson, Euan Gordon, Mike Firth, Krzysztof Chylinski, Amir Taheri-Ghahfarokhi, Mohammad Bohlooly-Y, Mike Snowden, Menelaos Pangalos, Barrett Nuttall, Pinar Akcakaya, Grzegorz Sienski, Marcello Maresca

Journal: Nat Commun

PubMed ID: 37673883

Doi: 10.1038/s41467-023-41240-7

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Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II

Authors: David Flores-Solis, Irina P Lushpinskaia, Anton A Polyansky, Arya Changiarath, Marc Boehning, Milana Mirkovic, James Walshe, Lisa M Pietrek, Patrick Cramer, Lukas S Stelzl, Bojan Zagrovic, Markus Zweckstetter

Journal: Nat Commun

PubMed ID: 37749095

Doi: 10.1038/s41467-023-41633-8

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One-step production of fully biotinylated and glycosylated human Fc gamma receptors

Authors: Minhyo Kang, Zening Wang, Xin Ge

Journal: Biotechnol Prog

PubMed ID: 37734055

Doi: 10.1002/btpr.3392

Products & Services: Proteins, Expression, Isolation and Analysis

Oligomeric State of β-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering

Authors: Wolfgang Knecht, S Zoë Fisher, Jiaqi Lou, Céleste Sele, Shumeng Ma, Anna Andersson Rasmussen, Nikos Pinotsis, Frank Kozielski

Journal: Int J Mol Sci

PubMed ID: 37686452

Doi: 10.3390/ijms241713649

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Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Authors: Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz

Journal: Nat Commun

PubMed ID: 37689716

Doi: 10.1038/s41467-023-41191-z

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CST2 is activated by RUNX1 and promotes pancreatic cancer progression by activating PI3K/AKT pathway

Authors: Rongwen Ou, Chengjie Lin, Youting Chen

Journal: Arch Biochem Biophys

PubMed ID: 37722526

Doi: 10.1016/j.abb.2023.109760

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Isofagomine inhibits multiple TcdB variants and protects mice from induced mortality

Authors: Ashleigh S Paparella, Isabella Brew, Huynh A Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C Tyler, Vern L Schramm

Journal: biorxiv

PubMed ID: 37781587

Doi: 10.1101/2023.09.19.558375

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A temperature dependent pilin promoter for production of thermostable enzymes in Thermus thermophilus

Authors: Lennart Kirchner, Volker Müller, Beate Averhoff

Journal: Microb Cell Fact

PubMed ID: 37726752

Doi: 10.1186/s12934-023-02192-1

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Prime editor-mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS-CoV-2 variants

Authors: Wenwen Zhao， Jifang Li, Xiao Wang， Wei Xu， Bao-Qing Gao， Jiangchao Xiang， Yaofeng Hou, Wei Liu, Jing Wu, Qilian Qi, Jia Wei, Xiaoyu Yang, Lu Lu,Li Yang, Jia Chen, Bei Yang

Journal: MedComm.

Doi: 10.1002/mco2.356

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Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore

Authors: Kefan Wang, Shanyu Zhang, Xiao Zhou, Xian Yang, Xinyue Li, Yuqin Wang, Pingping Fan, Yunqi Xiao, Wen Sun, Panke Zhang, Wenfei Li, Shuo Huang

Journal: Nat Methods

PubMed ID: 37749214

Doi: 10.1038/s41592-023-02021-8

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A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Range of Human and Viral CaaX Sequences

Authors: Emily R Hildebrandt, Anushka Sarkar, Rajani Ravishankar, June H Kim, Walter K Schmidt

Journal: biorxiv

PubMed ID: 37786692

Doi: 10.1101/2023.09.19.558494

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PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice

Authors: Samuel K Lee, Rida A Malik, Ji Zhou, Wei Wang, Peter L Gross, Jeffrey I Weitz, Rithwik Ramachandran, Bernardo L Trigatti

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 37675637

Doi: 10.1161/ATVBAHA.123.319767

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Nanopore sequencing of DNA-barcoded probes for highly multiplexed detection of microRNA, proteins and small biomarkers

Authors: Caroline Koch, Benedict Reilly-O'Donnell, Richard Gutierrez, Carla Lucarelli, Fu Siong Ng, Julia Gorelik, Aleksandar P Ivanov, Joshua B Edel

Journal: Nat Nanotechnol

PubMed ID: 37749222

Doi: 10.1038/s41565-023-01479-z

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CRISPR-ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia

Authors: Omer Gilan, Laure Talarmain, Charles C Bell, Daniel Neville, Kathy Knezevic, Daniel T Ferguson, Marion Boudes, Yih-Chih Chan, Chen Davidovich, Enid Y N Lam, Mark A Dawson

Journal: Nat Struct Mol Biol

PubMed ID: 37679565

Doi: 10.1038/s41594-023-01087-4

Products & Services: Proteins, Expression, Isolation and Analysis

Differential regulatory control of curli (csg) gene expression in Salmonella enterica serovar Typhi requires more than a functional CsgD regulator

Authors: Camille Ou, Charles M Dozois, France Daigle

Journal: Sci Rep

PubMed ID: 37689734

Doi: 10.1038/s41598-023-42027-y

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Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease

Authors: Yugendar R Alugubelli, Jing Xiao, Kaustav Khatua, Sathish Kumar, Yuying Ma, Xinyu R Ma, Veerabhadra R Vulupala, Sandeep R Atla, Lauren Blankenship, Demonta Coleman, Benjamin W Neuman, Wenshe Ray Liu, Shiqing Xu

Journal: biorxiv

PubMed ID: 37808777

Doi: 10.1101/2023.09.29.560163

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mRNA vaccines encoding fusion proteins of monkeypox virus antigens protect mice from vaccinia virus challenge

Authors: Fujun Hou, Yuntao Zhang, Xiaohu Liu, Yanal M Murad, Jiang Xu, Zhibin Yu, Xianwu Hua, Yingying Song, Jun Ding, Hongwei Huang, Ronghua Zhao, William Jia, Xiaoming Yang

Journal: Nat Commun

PubMed ID: 37739969

Doi: 10.1038/s41467-023-41628-5

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A Proteorhodopsin-Related Photosensor Expands the Repertoire of Structural Motifs Employed by Sensory Rhodopsins

Authors: Maryam Saliminasab, Yoichi Yamazaki, Alyssa Palmateer, Andrew Harris, Luiz Schubert, Pit Langner, Joachim Heberle, Ana-Nicoleta Bondar, Leonid S Brown

Journal: J Phys Chem B

PubMed ID: 37694950

Doi: 10.1021/acs.jpcb.3c04032

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RIG-I promotes immune evasion of colon cancer by modulating PD-L1 ubiquitination

Authors: Yangyang Zhang # 1, Lingxiu Zeng # 1, Meng Wang 1, Zhenwei Yang 1, Hailin Z 1, Liping Gao , Ranran Zhang , Jialong Liu , Wenqing Shan , Ying Chang ,Lan Liu , Qiu Zhao , Yong Li , Jing Liu

Journal: J Immunother Cancer .

PubMed ID: 37758653

Doi: 10.1136/jitc-2023-007313

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Validation of flavivirus infectious clones carrying fluorescent markers for antiviral drug screening and replication studies

Authors: Liubov Cherkashchenko , Nathalie Gros, Alice Trausch, Aymeric Neyret, Mathilde Hénaut, Gregor Dubois, Matthieu Villeneuve, Christine Chable-Bessia, Sébastien Lyonnais, Andres Merits, Delphine Muriaux

Journal: Front Microbiol

PubMed ID: 37779700

Doi: 10.3389/fmicb.2023.1201640

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Discovery and identification of a novel canine coronavirus causing a diarrhea outbreak in Vulpes

Authors: Yuting Liu, Yao Deng, Sheng Niu, Na Zhu, Jingdong Song, Xiaoshuang Zhang, Weiting Su, Wenhui Nie, Roujian Lu, David M Irwin, George Fu Gao, Wenling Wang, Qihui Wang, Wenjie Tan, Shuyi Zhang

Journal: Sci Bull (Beijing)

PubMed ID: 37758615

Doi: 10.1016/j.scib.2023.09.011

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Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors

Authors: Nicholas D Clark, Christopher Pham, Kurni Kurniyati, Ching Wooen Sze, Laurynn Coleman, Qin Fu, Sheng Zhang, Michael G Malkowski, Chunhao Li

Journal: PLoS Pathog

PubMed ID: 37747935

Doi: 10.1371/journal.ppat.1011674

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An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses

Authors: Feifei Xiong, Chi Zhang, Baoyuan Shang, Mei Zheng, Qi Wang, Yahong Ding, Jian Luo, Xiuling Li

Journal: Emerg Microbes Infect

PubMed ID: 37671994

Doi: 10.1080/22221751.2023.2256422

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