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Determinants of viscoelasticity and flow activation energy in biomolecular condensates

Authors: Ibraheem Alshareedah , Anurag Singh , Sean Yang , Vysakh Ramachandran , Alexander Quinn , Davit A Potoyan , Priya R Banerjee

Journal: SCIENCE ADVANCES

PubMed ID: 38363841

Doi: 10.1126/sciadv.adi6539

Products & Services: Peptide Synthesis

Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes

Authors: Filip Mihalič, Dahiana Arcila, Mats E Pettersson, Pouria Farkhondehkish, Eva Andersson, Leif Andersson, Ricardo Betancur-R, Per Jemth

Journal: Mol Biol Evol

PubMed ID: 38301272

Doi: 10.1093/molbev/msae018

Products & Services: Protein and Antibody Isolation

Human sequences form R-loop structures

Authors: Agata M Parsons, Kemin Su, Maya Daniels, Gerrit J Bouma, Gregory B Vanden Heuvel, Erik D Larson

Journal: MicroPubl Biol

PubMed ID: 38371318

Doi: 10.17912/micropub.biology.001058

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Tandem repeats of highly bioluminescent NanoLuc are refolded noncanonically by the Hsp70 machinery

Authors: Dimitra Apostolidou, Pan Zhang, Devanshi Pandya, Kaden Bock, Qinglian Liu, Weitao Yang, Piotr E Marszalek

Journal: Protein Sci

PubMed ID: 38284490

Doi: 10.1002/pro.4895

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The exposure to glyphosate on the integrity of intestinal epithelial tight junctions of chicks

Authors: Mohamed A Fathi, Dan Shen, Lu Luo, Yansen Li, Shaaban S Elnesr, Chunmei Li

Journal: J Environ Sci Health B

PubMed ID: 38400726

Doi: 10.1080/03601234.2024.2319006

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A Modified Tridecapeptide Probe for Imaging Cell Junction

Authors: Jingrui Li, Yuhan Wu, Chunyu Liu, Shu Zhang, Xin Su, Songbo Xie, Fengtang Yang

Journal: Molecules

PubMed ID: 38474514

Doi: 10.3390/molecules29051003

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Effects of polyphenol and gelatin types on the physicochemical properties and emulsion stabilization of polyphenol-crosslinked gelatin conjugates

Authors: Wenjuan Wu, Cuiping Shi, Ye Zi, Huan Gong, Lijia Chen, Guangyi Kan, Xichang Wang, Jian Zhong

Journal: Food Chem X

PubMed ID: 38440057

Doi: 10.1016/j.fochx.2024.101250

Products & Services: Protein Electrophoresis and Western

Gene-edited triple mutant Medicago plants do not flower

Authors: Axel Poulet, Min Zhao, Yongyan Peng, FangFei Tham, Mauren Jaudal, Lulu Zhang, Josien C van Wolfswinkel, Joanna Putterill

Journal: Front Plant Sci

PubMed ID: 38469328

Doi: 10.3389/fpls.2024.1357924

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Role of aminopeptidase N-like in the acquisition of begomoviruses by Bemisia tabaci, the whitefly vector

Authors: Yun-Yun Fan, Yao Chi, Na Chen, Wilmer J Cuellar, Xiao-Wei Wang

Journal: Insect Sci

PubMed ID: 38369384

Doi: 10.1111/1744-7917.13336

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PeptiVAX: A new adaptable peptides-delivery platform for development of CTL-based, SARS-CoV-2 vaccines

Authors: Sara Feola, Jacopo Chiaro, Manlio Fusciello, Salvatore Russo, Iivari Kleino, Leena Ylösmäki, Eliisa Kekäläinen, Johanna Hästbacka, Pirkka T Pekkarinen, Erkko Ylösmäki, Stefania Capone, Antonella Folgori, Angelo Raggioli, Carolina Boni, Camilla Tiezzi, Andrea Vecchi, Monica Gelzo, Hassen Kared, Alessandra Nardin, Michael Fehlings, Veronique Barban, Petra Ahokas, Tapani Viitala, Giuseppe Castaldo, Lucio Pastore, Paul Porter, Sari Pesonen, Vincenzo Cerullo

Journal: Int J Biol Macromol

PubMed ID: 38331062

Doi: 10.1016/j.ijbiomac.2024.129926

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In vitro evolution of diagnostic antibodies targeting native antigens in plasma by sandwich flow cytometry

Authors: Mingxia Liang, Fanlei Ran, Li Li, Haiying Hang, Lili An

Journal: Biotechnol J

PubMed ID: 38403438

Doi: 10.1002/biot.202300492

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Photoactivatable CRISPR/Cas12a Sensors for Biomarkers Imaging and Point-of-Care Diagnostics

Authors: Qing-Nan Li, Dong-Xia Wang, Dan-Ye Chen, Jia-Ao Lyu, Ya-Xin Wang, Shun-Li Wu, Hong-Xin Jiang, De-Ming Kong

Journal: Anal Chem

PubMed ID: 38305871

Doi: 10.1021/acs.analchem.3c05497

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Chagasin from Trypanosoma cruzi as a molecular scaffold to express epitopes of TSA-1 as soluble recombinant chimeras

Authors: Rosa Elena Cárdenas-Guerra, Octavio Montes-Flores, Edgar Ezequiel Nava-Pintor, Gerardo Reséndiz-Cardiel, Claudia Ivonne Flores-Pucheta, Yasmín Irene Rodríguez-Gavaldón, Rossana Arroyo, Maria Elena Bottazzi, Peter J Hotez, Jaime Ortega-López

Journal: Protein Expr Purif

PubMed ID: 38423156

Doi: 10.1016/j.pep.2024.106458

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Systematic Engineering of for Efficient Production of Cytidine 5'-Monophosphate

Authors: Min Zhou, Liyuan Wei, Chongzhi Wu, Wei Chen, Zhengju Tang

Journal: ACS Omega

PubMed ID: 38371780

Doi: 10.1021/acsomega.3c07713

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Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia

Authors: Xiaoqi Wang, Yuanjie Hao, Yujie Yin, Yunlong Hou, Ningxin Han, Yi Liu, Zhen Li, Yaru Wei, Kun Ma, Jiaojiao Gu, Yan Ma, Hui Qi, Zhenhua Jia

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 38343495

Doi: 10.2147/COPD.S436323

Products & Services: Protein and Antibody Isolation

A SARS-CoV-2 RBD vaccine fused to the chemokine MIP-3α elicits sustained murine antibody responses over 12 months and enhanced lung T-cell responses

Authors: James Tristan Gordy, Yinan Hui, Courtney Schill, Tianyin Wang, Fengyixin Chen, Kaitlyn Fessler, Jacob Meza, Yangchen Li, Alannah D Taylor, Rowan E Bates, Petros C Karakousis, Andrew Pekosz, Jaiprasath Sachithanandham, Maggie Li, Styliani Karanika, Richard B Markham

Journal: Front Immunol

PubMed ID: 38370404

Doi: 10.3389/fimmu.2024.1292059

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Supramolecular Synthons in Protein-Ligand Frameworks

Authors: Ronan J Flood, Niamh M Mockler, Aurélien Thureau, Maura Malinska, Peter B Crowley

Journal: Cryst Growth Des

PubMed ID: 38463617

Doi: 10.1021/acs.cgd.3c01480

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Structure of the WYL-domain containing transcription activator, DriD, in complex with ssDNA effector and DNA target site

Authors: Maria A Schumacher, Emily Cannistraci, Raul Salinas, Devin Lloyd, Ella Messner, Kevin Gozzi

Journal: Nucleic Acids Res

PubMed ID: 38142455

Doi: 10.1093/nar/gkad1198

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A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort

Authors: Oscar Alcazar, Sung-Ting Chuang, Gang Ren, Mitsunori Ogihara, Bobbie-Jo M Webb-Robertson, Ernesto S Nakayasu, Peter Buchwald, Midhat H Abdulreda

Journal: biorxiv

PubMed ID: 38405796

Doi: 10.1101/2024.02.09.579673

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A mutational atlas for Parkin proteostasis

Authors: Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer E Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: Nat Commun

PubMed ID: 38378758

Doi: 10.1038/s41467-024-45829-4

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Constitutive activation mechanism of a class C GPCR

Authors: Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V Robinson, Jaekyung Hyun, Vsevolod Katritch, Kwang Pyo Kim, Yunje Cho

Journal: Nat Struct Mol Biol

PubMed ID: 38332368

Doi: 10.1038/s41594-024-01224-7

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Metabolic engineering of Synechocystis sp PCC 6803 for the improved production of phenylpropanoids

Authors: Kateryna Kukil, Pia Lindberg

Journal: Microb Cell Fact

PubMed ID: 38369470

Doi: 10.1186/s12934-024-02330-3

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SPOP point mutations regulate substrate preference and affect its function

Authors: Yanran Deng, Wenhao Ding, Kaize Ma, Meixiao Zhan, Li Sun, Zizhang Zhou, Ligong Lu

Journal: Cell Death Dis

PubMed ID: 38409107

Doi: 10.1038/s41419-024-06565-1

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Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection

Authors: Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres

Journal: RSC Med Chem

PubMed ID: 38665834

Doi: 10.1039/d3md00724c

Products & Services: Protein and Antibody Isolation

Cystatin from the helminth upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

Authors: Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R Williams, Luis Caraballo

Journal: Front Immunol

PubMed ID: 38481989

Doi: 10.3389/fimmu.2024.1328401

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Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from

Authors: Davide Doni, Eva Cavallari, Martin Ezequiel Noguera, Hernan Gustavo Gentili, Federica Cavion, Gustavo Parisi, Maria Silvina Fornasari, Geppo Sartori, Javier Santos, Massimo Bellanda, Donatella Carbonera, Paola Costantini, Marco Bortolus

Journal: Int J Mol Sci

PubMed ID: 38339189

Doi: 10.3390/ijms25031912

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Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

Authors: Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Christine J F Nielsen, Marco Mele, Katrine R Hauerslev, Helene L Pedersen, Eva Balling, Pernille Vahl, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer

Journal: Br J Cancer

PubMed ID: 38310186

Doi: 10.1038/s41416-024-02591-0

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Stromal interaction molecule 1/microtubule-associated protein 1A/1B-light chain 3B complex induces metastasis of hepatocellular carcinoma by promoting autophagy

Authors: Jingchun Wang, Qichao Xie, Lei Wu, Yu Zhou, Yanquan Xu, Yu Chen, Jiangang Zhang, Ran Ren, Shiming Yang, Yongsheng Li, Huakan Zhao

Journal: MedComm (2020)

PubMed ID: 38344399

Doi: 10.1002/mco2.482

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A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation and PDE activity

Authors: Dareen Mikheil, Matthew A Larsen, Kevin Hsiao, Nathan H Murray, Tim Ugo, Hui Wang, Said A Goueli

Journal: Sci Rep

PubMed ID: 38396287

Doi: 10.1038/s41598-024-55038-0

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Gonococcal OMV-delivered PorB induces epithelial cell mitophagy

Authors: Shuai Gao, Lingyu Gao, Dailin Yuan, Xu'ai Lin, Stijn van der Veen

Journal: Nat Commun

PubMed ID: 38396029

Doi: 10.1038/s41467-024-45961-1

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SARS-CoV-2 targets ribosomal RNA biogenesis

Authors: V Talya Yerlici, Audrey Astori, Nevraj S Kejiou, Chris A Jordan, Negin Khosraviani, Janet N Y Chan, Razqallah Hakem, Brian Raught, Alexander F Palazzo, Karim Mekhail

Journal: Cell Rep

PubMed ID: 38427561

Doi: 10.1016/j.celrep.2024.113891

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Shrimp injection with dsRNA targeting the microsporidian EHP polar tube protein reduces internal and external parasite amplification

Authors: Satika Yuanlae, Tharinthon Prasartset, Onrapak Reamtong, Natthinee Munkongwongsiri, Muthita Panphloi, Thanchanok Preechakul, Rungkarn Suebsing, Siripong Thitamadee, Anuphap Prachumwat, Ornchuma Itsathitphaisarn, Suparat Taengchaiyaphum, Chanadda Kasamechotchung

Journal: Sci Rep

PubMed ID: 38413745

Doi: 10.1038/s41598-024-55400-2

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Engineering recombinant replication-competent bluetongue viruses expressing reporter genes for and non-invasive studies

Authors: Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Alejandro Marín-López, Miguel Illescas-Amo, Germán Andrés, Eva Calvo-Pinilla, Gema Lorenzo, Piet A van Rijn, Javier Ortego, Aitor Nogales

Journal: Microbiol Spectr

PubMed ID: 38353566

Doi: 10.1128/spectrum.02493-23

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Rapid Decline of SARS-CoV-2 Viral Load in Single vs Double-Dose (Short-Interval <6 Weeks) ChAdOx nCoV-19 Vaccinated Health-Care Workers

Authors: Arnab Ghosh, Poonam Kanta, Manisha Ramola, Ritin Mohindra, Kapil Goyal, Roop Kishore, Vikas Suri, P V M Lakshmi, Chanderkanta Chauhan, Manisha Sharma, Partha Rakshit, Kalaiarasan Ponnusamy, Tanzin Dikid, Mini P Singh

Journal: Curr Microbiol

PubMed ID: 38353761

Doi: 10.1007/s00284-023-03603-7

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Site-Directed Mutagenesis of VvCYP76F14 (Cytochrome P450) Unveils Its Potential for Selection in Wine Grape Varieties Linked to the Development of Wine Bouquet

Authors: Bin Peng, Jianguo Ran, Yiyang Li, Meiling Tang, Huilin Xiao, Shengpeng Shi, Youzheng Ning, Adeeba Dark, Jin Li, Xueqiang Guan, Zhizhong Song

Journal: J Agric Food Chem

PubMed ID: 38334101

Doi: 10.1021/acs.jafc.3c09083

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Applying valency-based immuno-selection to generate broadly cross-reactive antibodies against influenza hemagglutinins

Authors: Daniëla Maria Hinke, Ane Marie Anderson, Kirankumar Katta, Marlene Fyrstenberg Laursen, Demo Yemane Tesfaye, Ina Charlotta Werninghaus, Davide Angeletti, Gunnveig Grødeland, Bjarne Bogen, Ranveig Braathen

Journal: Nat Commun

PubMed ID: 38346952

Doi: 10.1038/s41467-024-44889-w

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Advances and Challenges in SARS-CoV-2 Detection: A Review of Molecular and Serological Technologies

Authors:

Journal: Diagnostics (Basel)

PubMed ID: 38472991

Doi: 10.3390/diagnostics14050519

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Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8T cell function and its impact against pancreatic ductal adenocarcinoma

Authors: Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang, Xiangmin Tong

Journal: Oncoimmunology

PubMed ID: 38419758

Doi: 10.1080/2162402X.2024.2322173

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Evaluation of the therapeutic effect of a novel bacteriophage in the healing process of infected wounds with Klebsiella pneumoniae in mice

Authors: Fatemeh Zeynali Kelishomi, Farhad Nikkhahi, Samira Amereh, Fatemeh Ghayyaz, Seyed Mahmoud Amin Marashi, Amir Javadi, Gholamhassan Shahbazi, Mohadeseh Khakpour

Journal: J Glob Antimicrob Resist

PubMed ID: 38307250

Doi: 10.1016/j.jgar.2024.01.018

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Residues within the LptC transmembrane helix are critical for Escherichia coli LptB FG ATPase regulation

Authors: Nicholas P Cina, Dara W Frank, Candice S Klug

Journal: Protein Sci

PubMed ID: 38131105

Doi: 10.1002/pro.4879

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Structural and functional comparisons of salivary α-glucosidases from the mosquito vectors Aedes aegypti, Anopheles gambiae, and Culex quinquefasciatus

Authors: Adeline E Williams, Apostolos G Gittis, Karina Botello, Phillip Cruz, Ines Martin-Martin, Paola Carolina Valenzuela Leon, Benjamin Sumner, Brian Bonilla, Eric Calvo

Journal: Insect Biochem Mol Biol

PubMed ID: 38428508

Doi: 10.1016/j.ibmb.2024.104097

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The catalytic action of human d-lactate dehydrogenase is severely inhibited by oxalate and is impaired by mutations triggering d-lactate acidosis

Authors: Alessandra Stefan, Alberto Mucchi, Alejandro Hochkoeppler

Journal: Arch Biochem Biophys

PubMed ID: 38373542

Doi: 10.1016/j.abb.2024.109932

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Development and characterization of DIA 123, a fully human intact anti-CEACAM1 monoclonal antibody

Authors: Michela Centonze, Valentina Fiori, Maciej Kujawski, Lin Li, Patty Wong, Lindsay Williams, Tomas Di Mambro, Sabrina Dominici, Angelo Sparti, John E Shively, Mauro Magnani

Journal: PLoS ONE

PubMed ID: 38346003

Doi: 10.1371/journal.pone.0295345

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Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer

Authors: Kazuto Suda, Atsushi Okabe, Junichi Matsuo, Linda Shyue Huey Chuang, Ying Li, Nawaphat Jangphattananont, Naing Naing Mon, Khine Nyein Myint, Akihiro Yamamura, Jimmy Bok-Yan So, Dominic Chih-Cheng Voon, Henry Yang, Khay Guan Yeoh, Atsushi Kaneda, Yoshiaki Ito

Journal: Cancer Res Commun

PubMed ID: 38240752

Doi: 10.1158/2767-9764.CRC-22-0165

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Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)

Authors: Ahmed Mohamed Hassan, Arwa Ahmed Zehairy, Al-Judaibi Awatif Abid, Sayed Sartaj Sohrab, Ibraheem Azhar Esam

Journal: Bioinformation

PubMed ID: 38497067

Doi: 10.6026/973206300200091

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Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

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Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

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Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Authors: Xiaozhu Zhang, Briana Van Treeck, Connor A. Horton, Jeremy J. R. McIntyre, Sarah M. Palm, Justin L. Shumate & Kathleen Collins

Journal: Nat Biotechnol

PubMed ID: 38379101

Doi: 10.1038/s41587-024-02137-y

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Disordered regions mediate the interaction of p53 and MRE11

Authors: Sinem Usluer , Markus Galhuber , Yukti Khanna , Benjamin Bourgeois , Emil Spreitzer , Helene Michenthaler, Andreas Prokesch, Tobias Madl

Journal: Cell Research

PubMed ID: 38123020

Doi: 10.1016/j.bbamcr.2023.119654

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Comprehensive Genomic Analysis Identifies a Diverse Landscape of Sideroblastic and Nonsideroblastic Iron-Related Anemias with Novel and Pathogenic Variants in an Iron-Deficient Endemic Setting

Authors: Pankaj Sharma, Prateek Bhatia, Minu Singh, Manu Jamwal, Swetha Pallavelangini, Reena Das, Pankaj Malhotra, Savita V Attri, Sarah Ducamp, Mark D Fleming, Amita Trehan

Journal: J Mol Diagn

PubMed ID: 38360212

Doi: 10.1016/j.jmoldx.2024.01.011

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Graphene Quantum Dots (GQD)-Mediated dsRNA Delivery for the Control of Fusarium Head Blight Disease in Wheat

Authors: Binod Gyawali, Rahim Rahimi, Houshang Alizadeh, Mohsen Mohammadi

Journal: ACS Appl Bio Mater

PubMed ID: 38422985

Doi: 10.1021/acsabm.3c00972

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miR-30e-5p regulates leukemia stem cell self-renewal through the Cyb561/ROS signaling pathway

Authors: Yanwen Ge, Mei Hong, Yu Zhang, Jiachen Wang, Lei Li, Hongkai Zhu, Yue Sheng, Wen-Shu Wu, Zhonghui Zhang

Journal: Haematologica

PubMed ID: 37584287

Doi: 10.3324/haematol.2023.282837

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Ebselen and TPI-1, as RecG helicase inhibitors, potently enhance the susceptibility of Pseudomonas aeruginosa to DNA damage agents

Authors: Longheng Li, Binbin Guo, Lin Dai, Chun Liu, Zhonghui Lin

Journal: Biochem Pharmacol

PubMed ID: 38354956

Doi: 10.1016/j.bcp.2024.116051

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Development, validation and application of an ion-pair reversed-phase liquid chromatography-tandem mass spectrometry method for the quantification of nusinersen

Authors: Xiao Zhang, Chunjie Sha, Wei Zhang, Fengjuan Zhao, Mingli Zhu, Guangyi Leng, Wanhui Liu

Journal: Bioanalysis

PubMed ID: 38334103

Doi: 10.4155/bio-2023-0218

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Evaluation of nucleotide MALDI-TOF-MS for the identification of species

Authors: Yelei Zhu, Zhengwei Liu, Lina Peng, Bin Liu, Kunyang Wu, Mingwu Zhang, Xiaomeng Wang, Junhang Pan

Journal: Front Cell Infect Microbiol

PubMed ID: 38379773

Doi: 10.3389/fcimb.2024.1335104

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PDGFRβ-Antagonistic Affibody-Mediated Tumor-Targeted Tumor Necrosis Factor-Alpha for Enhanced Radiotherapy in Lung Cancer

Authors: Xiaohui Tang, Jie Chen, Zhenxiong Zhao, Jie Liu, Ranfei Yu, Kunlong Zhao, Fei Wang, Yang Li, Baoqing Tian, Dandan Yuan, Yuguo Liu, Qing Fan

Journal: Mol Pharm

PubMed ID: 38364870

Doi: 10.1021/acs.molpharmaceut.3c00869

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Multitrait engineering of Hassawi red rice for sustainable cultivation

Authors: Khalid Sedeek, Nahed Mohammed, Yong Zhou, Andrea Zuccolo, Krishnaveni Sanikommu, Sunitha Kantharajappa, Noor Al-Bader, Manal Tashkandi, Rod A Wing, Magdy M Mahfouz

Journal: Plant Sci

PubMed ID: 38325660

Doi: 10.1016/j.plantsci.2024.112018

African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway

Authors: Guangqiang Ye, Zhaoxia Zhang, Xiaohong Liu, Hongyang Liu, Weiye Chen, Chunying Feng, Jiangnan Li, Qiongqiong Zhou, Dongming Zhao, Shuai Zhang, Hefeng Chen, Zhigao Bu, Li Huang, Changjiang Weng

Journal: J Virol

PubMed ID: 38353534

Doi: 10.1128/jvi.01834-23

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Improvement of Carotenoids' Production by Increasing the Activity of Beta-Carotene Ketolase with Different Strategies

Authors: Qiaomian Zhou, Danqiong Huang, Haihong Yang, Zeyu Hong, Chaogang Wang

Journal: Microorganisms

PubMed ID: 38399781

Doi: 10.3390/microorganisms12020377

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Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies

Authors: Jing Lu, Shudan Tan, Hao Gu, Kunpeng Liu, Wei Huang, Zhaoli Yu, Guoliang Lu, Zihan Wu, Xiaobo Gao, Jinghua Zhao, Zongting Yao, Feng Yi, Yantao Yang, Hu Wang, Xue Hu, Mingqing Lu, Wei Li, Hui Zhou, Hang Yu, Chao Shan, Jinzhong Lin

Journal: Emerg Microbes Infect

PubMed ID: 38377136

Doi: 10.1080/22221751.2024.2321994

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Supramolecular self-assembly strategies of natural-based β-lactoglobulin modulating bitter perception of goat milk-derived bioactive peptides

Authors: Rong Zhang, Wei Jia

Journal: J Dairy Sci

PubMed ID: 38310962

Doi: 10.3168/jds.2023-24386

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Atypical Plant miRNA cal-miR2911: Robust Stability against Food Digestion and Specific Promoting Effect on in Mice

Authors: Qin Xu, Jianing Wang, Yi Zhang, Ying Li, Xinshu Qin, Yirao Xin, Yinglei Li, Ke Xu, Xingbin Yang, Xingyu Wang

Journal: J Agric Food Chem

PubMed ID: 38393993

Doi: 10.1021/acs.jafc.3c09511

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Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition

Authors: Sedona Eve Murphy, Alistair Nicol Boettiger

Journal: Nat Genet

PubMed ID: 38361032

Doi: 10.1038/s41588-024-01661-6

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Performance of Three Anti-SARS-CoV-2 Anti-S and One Anti-N Immunoassays for the Monitoring of Immune Status and Vaccine Response

Authors: Y Victoria Zhang, Attila Kumanovics, Joesph Wiencek, Stacy E F Melanson, Tanzy Love, Alan H B Wu, Zhen Zhao, Qing H Meng, David D Koch, Fred S Apple, Caitlin R Ondracek, Robert H Christenson

Journal: Viruses

PubMed ID: 38400067

Doi: 10.3390/v16020292

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Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer

Authors: Yingmin Jin, Aimin Jiang, Liying Sun, Yue Lu

Journal: BMC Cancer

PubMed ID: 38383342

Doi: 10.1186/s12885-024-11964-w

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CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells

Authors: Hongjie Wang, Theo Koob, Jonathan R Fromm, Ajay Gopal, Darrick Carter, André Lieber

Journal: Cancer Biol Ther

PubMed ID: 38361357

Doi: 10.1080/15384047.2024.2314322

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Using for High-Yield Production of Challenging Expression Targets and for Protein Perdeuteration

Authors: Natalia Mojica, Flore Kersten, Mateu Montserrat-Canals, G Robb Huhn Iii, Abelone M Tislevoll, Gabriele Cordara, Ken Teter, Ute Krengel

Journal: Biochemistry

PubMed ID: 38359344

Doi: 10.1021/acs.biochem.3c00612

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CRISPR Ribonucleoprotein-Mediated Precise Editing of Multiple Genes in Porcine Fibroblasts

Authors: Xiaochen Guo, Chang Liu, Yunjing Zhao, Chaoqian Jiang, Junxue Jin, Zhonghua Liu, Yanshuang Mu

Journal: Animals (Basel)

PubMed ID: 38396618

Doi: 10.3390/ani14040650

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Creation of a point-of-care therapeutics sensor using protein engineering, electrochemical sensing and electronic integration

Authors: Rong Cai, Chiagoziem Ngwadom, Ravindra Saxena, Jayashree Soman, Chase Bruggeman, David P Hickey, Rafael Verduzco, Caroline M Ajo-Franklin

Journal: Nat Commun

PubMed ID: 38402222

Doi: 10.1038/s41467-024-45789-9

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NEAT1 repression by MED12 creates chemosensitivity in p53 wild-type breast cancer cells

Authors: Shengjie Zhang, Eui-Jun Kim, Junfeng Huang, Peng Liu, Kristine Donahue, Qinchuan Wang, Yidan Wang, Sean Mcilwain, Ling Xie, Xian Chen, Lingjun Li, Wei Xu

Journal: FEBS J

PubMed ID: 38380720

Doi: 10.1111/febs.17097

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NK-92MI Cells Engineered with Anti-claudin-6 Chimeric Antigen Receptors in Immunotherapy for Ovarian Cancer

Authors: Junping Li, Hong Hu, Hui Lian, Shuo Yang, Manting Liu, Jinping He, Bihui Cao, Dongni Chen, Yuling Hu, Chen Zhi, Yan Shen, Xiaodie Ye, Bingjia He, Ming Zhao, Weijun Fan, Linfeng Xu, Rom Leidner, Qingde Wu, Lili Yang, Zhenfeng Zhang

Journal: Int J Biol Sci

PubMed ID: 38481806

Doi: 10.7150/ijbs.88539

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Vaccine Based on Recombinant Fusion Protein Combining Hepatitis B Virus PreS with SARS-CoV-2 Wild-Type- and Omicron-Derived Receptor Binding Domain Strongly Induces Omicron-Neutralizing Antibodies in a Murine Model

Authors: Pia Gattinger, Bernhard Kratzer, Al Nasar Ahmed Sehgal, Anna Ohradanova-Repic, Laura Gebetsberger, Gabor Tajti, Margarete Focke-Tejkl, Mirjam Schaar, Verena Fuhrmann, Lukas Petrowitsch, Walter Keller, Sandra Högler, Hannes Stockinger, Winfried F Pickl, Rudolf Valenta

Journal: Vaccines (Basel)

PubMed ID: 38543863

Doi: 10.3390/vaccines12030229

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Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase

Authors: Joshua J Maw, Jesse A Coker, Tarun Arya, Christopher M Goins, Dhiraj Sonawane, Sang Hoon Han, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Nancy S Wang, Hannelore V Heemers, Jonathan D Macdonald, Shaun R Stauffer

Journal: J Med Chem

PubMed ID: 38330278

Doi: 10.1021/acs.jmedchem.3c01807

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mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms

Authors: Yusuf Ali, Celso E Gomez-Sanchez, Maria Plonczynski, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Elise P Gomez-Sanchez

Journal: Endocrinology

PubMed ID: 38325289

Doi: 10.1210/endocr/bqae015

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Exploring the immunogenicity of Rv2201-519: A T-cell epitope-based antigen derived from Mycobacterium tuberculosis AsnB with implications for tuberculosis infection detection and vaccine development

Authors: Xiuli Luan, Xueting Fan, Guilian Li, Mchao Li, Na Li, Yuhan Yan, Xiuqin Zhao, Haican Liu, Kanglin Wan

Journal: Int Immunopharmacol

PubMed ID: 38342063

Doi: 10.1016/j.intimp.2024.111542

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Discovery of Two Novel Immunoepitopes and Development of Peptide-based Sarcoidosis Immunoassay

Authors: Changya Peng , Jaya Talreja , Brennen Steinbauer , Kazuhiko Shinki , Laura L Koth , Lobelia Samavati

Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PubMed ID: 38385694

Doi: 10.1164/rccm.202306-1054OC

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An oncolytic virus–T cell chimera for cancer immunotherapy

Authors: Yuxuan Chen , Xiaohong Chen , Weier Bao , Gang Liu , Wei Wei , Yuan Ping

Journal: Nat Biotechnol .

PubMed ID: 38336902

Doi: 10.1038/s41587-023-02118-7

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Distinct structural variants and repeat landscape shape the genomes of the ancient grapes Aglianico and Falanghina

Authors: Riccardo Aversano, Marina Iovene , Salvatore Esposito , Alberto L'Abbate , Clizia Villano , Ermanno Di Serio , Maria Francesca Cardone , Carlo Bergamini , Riccardo Aiese Cigliano , Vincenzo D'Amelia , Luigi Frusciante , Domenico Carputo

Journal: BMC Plant Biol.

PubMed ID: 38317087

Doi: 10.1186/s12870-024-04778-2

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Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1

Authors: Xiangwei Wu, Yunxiang Du, Lu-Jun Liang, Ruichao Ding, Tianyi Zhang, Hongyi Cai, Xiaolin Tian, Man Pan, Lei Liu

Journal: Nat Commun .

PubMed ID: 38341401

Doi: 10.1038/s41467-024-45635-y

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Mage Transposon: A Novel Gene Delivery System for Mammalian Cells

Authors: Jinghan Tian, Doudou Tong, Zhendong Li, Erqiang Wang, Yifei Yu, Hangya Lv, Zhendan Hu, Fang Sun, Guoping Wang, Min He, Tian Xia

Journal: Nucleic Acids Res .

PubMed ID: 38300794

Doi: 10.1093/nar/gkae048

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Bicistronic expression of nuclear transgenes in Chlamydomonas reinhardtii

Authors: Nick Jacobebbinghaus, Kyle J Lauersen, Olaf Kruse, Thomas Baier

Journal: The Plant Journal

PubMed ID: 38415961

Doi: 10.1111/tpj.16677

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An Antioxidative and Active Shrinkage Hydrogel Integratedly Promotes Re-Epithelization and Skin Constriction for Enhancing Wound Closure

Authors: Jiacheng Sun, Wang Jia, Hedong Qi, Jiawei Huo, Xiaodan Liao, Yuan Xu, Jun Wang, Zihao Sun, Yang Liu, Jingchao Liu, Mingming Zhen, Chunru Wang, Chunli Bai

Journal: Adv Mater

PubMed ID: 38332741

Doi: 10.1002/adma.202312440

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Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA. 2.86 and FLip variants

Authors: Panke Qu 1, Kai Xu 1, Julia N Faraone 2, Negin Goodarzi 1, Yi-Min Zheng 1, Claire Carlin 3, Joseph S Bednash 4, Jeffrey C Horowitz 4, Rama K Mallampalli 4, Linda J Saif 5, Eugene M Oltz 6, Daniel Jones 7, Richard J Gumina 8, Shan-Lu Liu

Journal: Cell

PubMed ID: 38194968

Doi: 10.1016/j.cell.2023.12.026

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A Cancer Nanovaccine for Co-Delivery of Peptide Neoantigens and Optimized Combinations of STING and TLR4 Agonists

Authors: Jessalyn J. Baljon, Alexander J. Kwiatkowski, Hayden M. Pagendarm, Payton T. Stone, Amrendra Kumar, Vijaya Bharti, Jacob A. Schulman, Kyle W. Becker, Eric W. Roth, Plamen P. Christov, Sebastian Joyce, and John T. Wilson*

Journal: ACS Nano

PubMed ID: 38386282

Doi: 10.1021/acsnano.3c04471

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SPR spectroscopic analysis of myosin binding to wild type and mutant UNC45B

Authors: Silvana Valdebenito, Eliseo Eugenin, Andres Oberhauser

Journal: MicroPubl Biol

PubMed ID: 38404916

Doi: 10.17912/micropub.biology.001131

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Essential functions of Inositol hexakisphosphate (IP6) in Murine Leukemia Virus replication

Authors: Banhi Biswas, Kin Kui Lai, Harrison Bracey, Siddhartha A K Datta, Demetria Harvin, Gregory A Sowd, Christopher Aiken, Alan Rein

Journal: biorxiv

PubMed ID: 38464197

Doi: 10.1101/2024.02.27.581940

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Examination of SARS-CoV-2 serological test results from multiple commercial and laboratory platforms with an in-house serum panel

Authors: Sandra N Lester, Megan Stumpf, Brandi D Freeman, Lisa Mills, Jarad Schiffer, Vera Semenova, Tao Jia, Rita Desai, Peter Browning, Bailey Alston, Muyiwa Ategbole, Shanna Bolcen, Alexander Chen, Ebenezer David, Panagiotis Manitis, Heather Tatum, Yunlong Qin, Briana Zellner, Jan Drobeniuc, Alexandra Tejada-Strop, Payel Chatterjee, Punya Shrivastava-Ranjan, M Harley Jenks, Laura K McMullan, Mike Flint, Christina F Spiropoulou, Glenn P Niemeyer, Bonnie J Werner, Christopher J Bean, Jeffrey A Johnson, Alex R Hoffmaster, Panayampalli S Satheshkumar, Amy J Schuh, S Michele Owen, Natalie J Thornburg

Journal: Access Microbiol

PubMed ID: 38482357

Doi: 10.1099/acmi.0.000463.v4

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Efficient production of 2'-fucosyllactose from fructose through metabolically engineered recombinant Escherichia coli

Authors: Ran You, Lei Wang, Meirong Hu, Yong Tao

Journal: Microb Cell Fact

PubMed ID: 38303005

Doi: 10.1186/s12934-024-02312-5

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Imaging of extracellular and intracellular ATP in pancreatic beta cells reveals correlation between glucose metabolism and purinergic signalling

Authors: Seyed M Ghiasi, Nynne M Christensen, Per A Pedersen, Emil Z Skovhøj, Ivana Novak

Journal: Cell Signal

PubMed ID: 38373668

Doi: 10.1016/j.cellsig.2024.111109

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Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

Authors: Daniel J Barrero, Sithara S Wijeratne, Xiaowei Zhao, Grace F Cunningham, Yan Rui, Christian R Nelson, Arimura Yasuhiro, Hironori Funabiki, Charles L Asbury, Zhiheng Yu, Radhika Subramanian, Sue Biggins

Journal: biorxiv

PubMed ID: 38464254

Doi: 10.1101/2024.02.28.582571

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A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

Authors: Lorena M Coria , Juan Manuel Rodriguez , Agostina Demaria , Laura A Bruno , Mayra Rios Medrano , Celeste Pueblas Castro , Eliana F Castro , Sabrina A Del Priore , Andres C Hernando Insua , Ingrid G Kaufmann , Lucas M Saposnik , William B Stone , Lineia Prado , Ulises S Notaro , Ayelen N Amweg , Pablo U Diaz , Martin Avaro , Hugo Ortega , Ana Ceballos , Valeria Krum , Francisco M Zurvarra , Johanna E Sidabra , Ignacio Drehe , Jonathan A Baqué , Mariana Li Causi , Analia V De Nichilo , Cristian J Payes , Teresa Southard , Julio C Vega , Albert J Auguste , Diego E Álvarez , Juan M Flo , Karina A Pasquevich , Juliana Cassataro

Journal: Nat Commun

PubMed ID: 38307851

Doi: 10.1038/s41467-024-45180-8

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The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors

Authors: Luisa Statello , José Miguel Fernandez-Justel , Jovanna González , Marta Montes , Alessia Ranieri , Enrique Goñi , Aina M Mas , Maite Huarte

Journal: Nat Commun

PubMed ID: 38302450

Doi: 10.1038/s41467-024-45183-5

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Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1

Authors: Leon Tejwani, Neal G Ravindra, Changwoo Lee, Yubao Cheng, Billy Nguyen, Kimberly Luttik, Luhan Ni, Shupei Zhang, Logan M Morrison, John Gionco, Yangfei Xiang, Jennifer Yoon, Hannah Ro, Fatema Haidery, Rosalie M Grijalva, Eunwoo Bae, Kristen Kim , Regina T Martuscello, Harry T Orr, Huda Y Zoghbi , Hayley S McLoughlin, Laura P W Ranum, Vikram G Shakkottai, Phyllis L Faust, Siyuan Wang, David van Dijk, Janghoo Lim

Journal: Neuron

PubMed ID: 38016472

Doi: 10.1016/j.neuron.2023.10.039

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Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis

Authors: Zhentao Zi 1 2, Yi Rao

Journal: Sci Adv

PubMed ID: 38306436

Doi: 10.1126/sciadv.adj0146

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Unveiling PET Hydrolase Surface Dynamics through Fluorescence Microscopy

Authors: A P Rennison, A Nousi, P Westh, R Marie, M S Møller

Journal: Chembiochem

PubMed ID: 38224131

Doi: 10.1002/cbic.202300661

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The expression of genes encoding novel Sesame oleosin variants facilitates enhanced triacylglycerol accumulation in Arabidopsis leaves and seeds

Authors: Sanket Anaokar, Yuanxue Liang, Xiao-Hong Yu, Yingqi Cai, Yuanheng Cai, John Shanklin

Journal: New Phytol

PubMed ID: 38329350

Doi: 10.1111/nph.19548

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Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside

Authors: Julia Heinzelbecker, Marte Fauskanger, Ida Jonson, Ute Krengel, Geir Åge Løset, Ludvig Munthe, Anders Tveita

Journal: Front Immunol

PubMed ID: 38370401

Doi: 10.3389/fimmu.2024.1331345

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CD39 tumor infiltrating T cells from colorectal cancers exhibit dysfunctional phenotype

Authors: Yuan Feng, Xin Xu, Jiaxin Zhang, Christopher Sanderson, Jun Xia, Zhang Bu, Yili Yang, Peng Yang, Zhiliang Lu

Journal: Am J Cancer Res

PubMed ID: 38455401

Doi: 10.62347/IZEN3736

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NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route

Authors: Obed Boadi Amissah, Wenfang Chen, Jean de Dieu Habimana, Yirong Sun, Lihui Lin, Yujie Liu, Ling Wang, Zhaoming Liu, Omar Mukama, Rajesh Basnet, Hohua Liu, Junyi Li, Xuanyan Ding, Lingshuang Lv, Min Chen, Yalin Liang, Rongqi Huang, Zhiyuan Li

Journal: Cancer Cell Int

PubMed ID: 38336680

Doi: 10.1186/s12935-024-03249-w

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Exploring the ATG9A interactome uncovers interaction with VPS13A

Authors: Alexander R van Vliet, Harold B J Jefferies, Peter A Faull, Jessica Chadwick, Fairouz Ibrahim, Mark J Skehel, Sharon A Tooze

Journal: J Cell Sci

PubMed ID: 38294121

Doi: 10.1242/jcs.261081

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