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Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2)

Authors: Jingbo Yi, Boya Qi, Jian Yin, Ruochong Li, Xudong Chen, Junhan Hu, Guohui Li, Sensen Zhang, Yuebin Zhang, Maojun Yang

Journal: Nat Commun

PubMed ID: 38012235

Doi: 10.1038/s41467-023-43580-w

Products & Services: Proteins, Expression, Isolation and Analysis

Structure-directed bioengineering the lid1 of cold-adapted Pseudomonas sp TB11 esterase to boost catalytic capacity

Authors: Linlin Sha, Wen-Sen He, Tian Zheng, Yang Fei, Yu Fang, Huqing Yang, Gang Chen

Journal: Int J Biol Macromol

PubMed ID: 37992944

Doi: 10.1016/j.ijbiomac.2023.128302

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MiR126-targeted-nanoparticles combined with PI3K/AKT inhibitor as a new strategy to overcome melanoma resistance

Authors: Maria Beatrice Arasi, Gabriele De Luca, Laura Chronopoulou, Francesca Pedini, Eleonora Petrucci, Michela Flego, Annarita Stringaro, Marisa Colone, Luca Pasquini, Massimo Spada, Valentina Lulli, Maria Chiara Perrotta, George Adrian Calin, Cleofe Palocci, Mauro Biffoni, Federica Felicetti, Nadia Felli

Journal: Mol Ther

PubMed ID: 37990493

Doi: 10.1016/j.ymthe.2023.11.021

Products & Services: Molecular Biology Reagents

Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences

Authors: Shane Kelly, Katherine Jl Jackson, Timothy J Peters, Dan Suan, Christopher C Goodnow

Journal: J Autoimmun

PubMed ID: 37952292

Doi: 10.1016/j.jaut.2023.103129

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Denovo production of resveratrol by engineered Saccharomyces cerevisiae W303-1a using pretreated Gracilaria corticata extracts

Authors: Nishanthika Thenmozhi Kulasekaran, Mary Leema Thilakam, Dharani Gopal, Jung-Kul Lee, Jeya Marimuthu

Journal: Biotechnol Lett

PubMed ID: 37987932

Doi: 10.1007/s10529-023-03441-4

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Development of a highly efficient prime editor system in mice and rabbits

Authors: Yuqiang Qian , Di Wang , Wenchao Niu , Zheng Shi , Mao Wu , Ding Zhao , Jinze Li , Xun Gao , Zhongtian Zhang , Liangxue Lai , Zhanjun Li

Journal: Cell Mol Life Sci .

PubMed ID: 37924393

Doi: 10.1007/s00018-023-05003-3

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Interactions of Histone Deacetylase 6 with DNA Damage Repair Factors Strengthen its Utility as a Combination Drug Target in High-Grade Serous Ovarian Cancer

Authors: Jolene M Duda, Stefani N Thomas

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38107255

Doi: 10.1021/acsptsci.3c00215

Products & Services: Proteins, Expression, Isolation and Analysis

Critical role of TPRN rings in the stereocilia for hearing

Authors: Jieyu Qi, Fangzhi Tan, Liyan Zhang, Yinyi Zhou, Ziyu Zhang, Qiuhan Sun, Nianci Li, Yuan Fang, Xin Chen, Yunhao Wu, Guisheng Zhong, Renjie Chai

Journal: Mol Ther

PubMed ID: 37952086

Doi: 10.1016/j.ymthe.2023.11.011

Products & Services: Proteins, Expression, Isolation and Analysis

DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones

Authors: Meital Abayev-Avraham, Yehuda Salzberg, Dar Gliksberg, Meital Oren-Suissa, Rina Rosenzweig

Journal: Nat Commun

PubMed ID: 37923706

Doi: 10.1038/s41467-023-42735-z

Products & Services: Proteins, Expression, Isolation and Analysis

A role for cytoglobin in regulating intracellular hydrogen peroxide and redox signals in the vasculature

Authors: Clinton Mathai, Frances Jourd'heuil, Le Gia Cat Pham, Kurrim Gilliard, Joseph Balnis, Annie Jen, Katherine A Overmyer, Joshua J Coon, Ariel Jaitovich, Benoit Boivin, David Jourd'heuil

Journal: biorxiv

PubMed ID: 37034694

Doi: 10.1101/2023.03.31.535146

Products & Services: Proteins, Expression, Isolation and Analysis

Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment

Authors: Xiang Dong, Chunlu Li, Chengsi Deng, Jingwei Liu, Danni Li, Tingting Zhou, Xindi Yang, Yunchan Liu, Qiqiang Guo, Yanling Feng, Yang Yu, Zhuo Wang, Wendong Guo, Siyi Zhang, Hongyan Cui, Cui Jiang, Xiwen Wang, Xiaoyu Song, Xun Sun, Liu Cao

Journal: Oncogene

PubMed ID: 37952080

Doi: 10.1038/s41388-023-02886-1

Products & Services: Proteins, Expression, Isolation and Analysis

A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease

Authors: Fernando Gonzalez-Ortiz, Pamela C L Ferreira, Armand González-Escalante, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R Kac, Michael Turton, Hlin Kvartsberg, Nicholas J Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, Tharick A Pascoal, Mary Ganguli, Anne D Cohen, Carolina Minguillon, Jose Contador, Marc Suárez-Calvet, Thomas K Karikari, Kaj Blennow

Journal: Alzheimers Dement

PubMed ID: 37975513

Doi: 10.1002/alz.13525

Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis

Authors: Ryan S Nett, Yaereen Dho, Chun Tsai, Daria Passow, Jaime Martinez Grundman, Yun-Yee Low, Elizabeth S Sattely

Journal: Nature

PubMed ID: 37938780

Doi: 10.1038/s41586-023-06716-y

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Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering

Authors: Derek Lee, Zachary Spencer Dunn, Wenbin Guo, Carl J Rosenthal, Natalie E Penn, Yanqi Yu, Kuangyi Zhou, Zhe Li, Feiyang Ma, Miao Li, Tsun-Ching Song, Xinjian Cen, Yan-Ruide Li, Jin J Zhou, Matteo Pellegrini, Pin Wang, Lili Yang

Journal: Nat Commun

PubMed ID: 37938576

Doi: 10.1038/s41467-023-42619-2

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Phages overcome bacterial immunity via diverse anti-defence proteins

Authors: Erez Yirmiya, Azita Leavitt, Allen Lu, Adelyn E Ragucci, Carmel Avraham, Ilya Osterman, Jeremy Garb, Sadie P Antine, Sarah E Mooney, Samuel J Hobbs, Philip J Kranzusch, Gil Amitai, Rotem Sorek

Journal: Nature

PubMed ID: 37992756

Doi: 10.1038/s41586-023-06869-w

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A streamlined, automated workflow to screen and triage large numbers of baculoviruses for protein expression

Authors: James J Kostas, Andrea T Partridge, Noel J Byrne, Richard W Edwards, Hua-Poo Su, Sandra B Gabelli, Alexei Brooun, Jennifer M Shipman

Journal: Protein Expr Purif

PubMed ID: 37995943

Doi: 10.1016/j.pep.2023.106406

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Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus

Authors: So Jin Bing, Morten Seirup, Trish T Hoang, Susana S Najera, Collin Britten, Stephanee L Warrington, Shiang-Ling Chu, Ronit Mazor

Journal: Nat Biomed Eng

PubMed ID: 37996615

Doi: 10.1038/s41551-023-01129-8

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Yeast Metabolic Engineering for Biosynthesis of Caffeic Acid-Derived Phenethyl Ester and Phenethyl Amide

Authors: Zi-Chen Jia, Duo Liu, Hai-Di Ma, Yu-Hui Cui, Hui-Min Li, Xia Li, Ying-Jin Yuan

Journal: ACS Synth Biol

PubMed ID: 38016187

Doi: 10.1021/acssynbio.3c00413

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Development of a multi-epitope vaccine candidate for leishmanial parasites applying immunoinformatics and approaches

Authors: Rahila Qureshi, Insaf Ahmed Qureshi

Journal: Front Immunol

PubMed ID: 38035118

Doi: 10.3389/fimmu.2023.1269774

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Environment relevant exposure of perfluorooctanoic acid accelerates the growth of hepatocellular carcinoma cells through mammalian target of rapamycin (mTOR) signal pathway

Authors: Jiawei Hong, Xiaoyan Wang, Hangbiao Jin, Yuanchen Chen, Yifan Jiang, Keyi Du, Diyu Chen, Shusen Zheng, Linping Cao

Journal: Environ Pollut

PubMed ID: 37967710

Doi: 10.1016/j.envpol.2023.122910

Products & Services: Proteins, Expression, Isolation and Analysis

Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products

Authors: Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori

Journal: Biotechnol Appl Biochem

PubMed ID: 38010900

Doi: 10.1002/bab.2538

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Development of an Electrochemical, Aptamer-Based Sensor for Dynamic Detection of Neuropeptide Y

Authors: Jordan M Seibold, Sanduni W Abeykoon, Ashley E Ross, Ryan J White

Journal: ACS Sens

PubMed ID: 38033269

Doi: 10.1021/acssensors.3c00855

Products & Services: Recombinant Proteins

Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption

Authors: Jin-Gang Yang, Bao Sun, Zheng Wang, Xing Li, Jia-Hui Gao, Jia-Jun Qian, Jiang Li, Wen-Jia Wei, Ping Zhang, Wei Wang

Journal: Cell Death Dis

PubMed ID: 37957146

Doi: 10.1038/s41419-023-06263-4

Products & Services: Proteins, Expression, Isolation and Analysis

The Peroxidase gene OsPrx114 Activated by OsWRKY50 Enhances Drought Tolerance through ROS Scavenging in Rice

Authors: Chao Zheng , Xuming Wang , Yue Xu , Shaomin Wang , Xin Jiang e , Xiuli Liub , Weijun Cui , Yueyan Wu , Chengqi Yan , Hongjia Liu , Yin Lu e, Jianping Chen a,b, and Jie Zhou

Journal: Plant Physiology and Biochemistry

Doi: 10.1016/j.plaphy.2023.108138

Products & Services: Proteins, Expression, Isolation and Analysis

Unraveling the salt tolerance of Phi29 DNA polymerase using compartmentalized self-replication and microfluidics platform

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yaping Gao , Qiwen Zhang , Salem Baldi , Tao Hong , Igor Ivanov , Yun He , Hui Tian

Journal: Front Microbiol .

PubMed ID: 38029082

Doi: 10.3389/fmicb.2023.1267196

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Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy

Authors: Daoyuan Xie , Yaomei Tian , Die Hu , Yuanda Wang , Yuling Yang , Bailing Zhou , Rui Zhang , Zhixiang Ren , Mohan Liu , Jie Xu , Chunyan Dong , Binyan Zhao , Li Yang

Journal: Signal Transduct Target Ther .

PubMed ID: 38016957

Doi: 10.1038/s41392-023-01683-2

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insights into asymmetric activation of the calciumsensing receptor–Gq complex

Authors: Shenglong Ling, Xianyu Meng, Yuan Zhang, Zhemin Xia, Yingxin Zhou, Fan Yang, Pan Shi, Chaowei Shi, Changlin Tian

Journal: Cell Res .

PubMed ID: 37919470

Doi: 10.1038/s41422-023-00892-2

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Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations

Authors: Brittany N Williams, Adam Draper, Patrick F Lang, Tylor R Lewis, Audrey L Smith, Steven J Mayerl, Marie Rougié, Jeremy M Simon, Vadim Y Arshavsky, Scott H Greenwald, David M Gamm, Isabel Pinilla, Benjamin D Philpot

Journal: Hum Mol Genet

PubMed ID: 37975905

Doi: 10.1093/hmg/ddad199

Products & Services: Proteins, Expression, Isolation and Analysis

IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjögren's syndrome

Authors: Xiaoyu Xia, Qiqiang Long, Jie Zha, Tingting Jiang, Junqiao Guo, Bo Jiang, Xiaojing Li, Genhong Yao

Journal: Int Immunol

PubMed ID: 37756640

Doi: 10.1093/intimm/dxad037

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Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease

Authors: Yael Gruper, Anette S B Wolff, Liad Glanz, Frantisek Spoutil, Mihaela Cuida Marthinussen, Adriana Osickova, Yonatan Herzig, Yael Goldfarb, Goretti Aranaz-Novaliches, Jan Dobeš, Noam Kadouri, Osher Ben-Nun, Amit Binyamin, Bar Lavi, Tal Givony, Razi Khalaila, Tom Gome, Tomáš Wald, Blanka Mrazkova, Carmel Sochen, Marine Besnard, Shifra Ben-Dor, Ester Feldmesser, Elisaveta M Orlova, Csaba Hegedűs, István Lampé, Tamás Papp, Szabolcs Felszeghy, Radislav Sedlacek, Esti Davidovich, Noa Tal, Dror S Shouval, Raanan Shamir, Carole Guillonneau, Zsuzsa Szondy, Knut E A Lundin, Radim Osicka, Jan Prochazka, Eystein S Husebye, Jakub Abramson

Journal: Nature

PubMed ID: 37993717

Doi: 10.1038/s41586-023-06776-0

Products & Services: Proteins, Expression, Isolation and Analysis

Mechanism of δ Mediated Transcription Activation in Bacillus subtilis: Interaction with α CTD of RNA Polymerase Stabilizes δ and Successively Facilitates the Open Complex Formation

Authors: Aniruddha Tewary, Ranjit Kumar Prajapati, Jayanta Mukhopadhyay

Journal: J Mol Biol

PubMed ID: 37972688

Doi: 10.1016/j.jmb.2023.168366

Products & Services: Proteins, Expression, Isolation and Analysis

RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms

Authors: Sudarsan Mugunthan, Lan Li Wong, Fernaldo Richtia Winnerdy, Stephen Summers, Muhammad Hafiz Bin Ismail, Yong Hwee Foo, Tavleen Kaur Jaggi, Oliver W Meldrum, Pei Yee Tiew, Sanjay H Chotirmall, Scott A Rice, Anh Tuân Phan, Staffan Kjelleberg, Thomas Seviour

Journal: Nat Commun

PubMed ID: 38012164

Doi: 10.1038/s41467-023-43533-3

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Effects of protoscoleces excretory-secretory products of Echinococcus granulosus on hepatocyte growth, function, and glucose metabolism

Authors: Guangyi Luo, Haiwen Li, Qiong Lu, Jiangtao Cao, Hailong Lv, Yufeng Jiang

Journal: Acta Trop

PubMed ID: 37944837

Doi: 10.1016/j.actatropica.2023.107066

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Ana Castillo Discusses Sexuality, Identity, and Life-Then and Now

Authors: Liliana C Gonzalez, Stacy I Macias

Journal: J Lesbian Stud

PubMed ID: 37791458

Doi: 10.1080/10894160.2023.2250670

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Diurnal regulation of alternative splicing associated with thermotolerance in rice by two glycine-rich RNA-binding proteins

Authors: Chuang Yang, Anni Luo, Hai-Ping Lu, Seth Jon Davis, Jian-Xiang Liu

Journal: Sci Bull (Beijing)

PubMed ID: 38044192

Doi: 10.1016/j.scib.2023.11.046

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2

Authors: Shengnan Zhu, Qingning Yuan, Xinzhu Li, Xinheng He, Shiyi Shen, Dongxue Wang, Junrui Li, Xi Cheng, Xiaoqun Duan, H Eric Xu, Jia Duan

Journal: Cell Rep

PubMed ID: 37952153

Doi: 10.1016/j.celrep.2023.113406

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Non-canonical MLL1 activity regulates centromeric phase separation and genome stability

Authors: Liang Sha, Zi Yang, Sojin An, Wentao Yang, Sungmin Kim, Hoon Oh, Jing Xu, Jun Yin, He Wang, Heinz-Josef Lenz, Woojin An, Uhn-Soo Cho, Yali Dou

Journal: Nat Cell Biol

PubMed ID: 37945831

Doi: 10.1038/s41556-023-01270-1

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ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer

Authors: Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma

Journal: Cell Signal

PubMed ID: 38000525

Doi: 10.1016/j.cellsig.2023.110979

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Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region

Authors: Qinhong Luo , Yue Ma , Huiting Liang , Yuan Feng , Na Liu, Chenshan Lian , Lizhi Zhu , Yuxin Ye , Zhihong Liu , Zhanfeng Hou , Sijin Chen , Yaqi Wang , Chuan Dai , Chunli Song , Min Zhang , Zhipeng He , Yun Xing , Wanjin Zhong , Shuiming Li , Jianlong Wu , Fei Lu , Feng Yin , Zigang Li

Journal: J Med Chem .

PubMed ID: 37922441

Doi: 10.1021/acs.jmedchem.3c01549

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An mRNA-based platform for the delivery of pathogen-specific IgA into mucosal secretions

Authors: Cailin E Deal, Angelene F Richards, Tracy Yeung, Max J Maron, Ziqiu Wang, Yen-Ting Lai, Brian R Fritz, Sunny Himansu, Elisabeth Narayanan, Ding Liu, Rositsa Koleva, Stuart Licht, Chiaowen J Hsiao, Ivana L Rajlic, Hillary Koch, Michael Kleyman, Mark E Pulse, William J Weiss, Jennifer E Doering, Samantha K Lindberg, Nicholas J Mantis, Andrea Carfi, Obadiah J Plante

Journal: Cell Rep Med

PubMed ID: 37918405

Doi: 10.1016/j.xcrm.2023.101253

Products & Services: Proteins, Expression, Isolation and Analysis

Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA)

Authors: Cheng-Wei Cheng, Chung-Yi Wu, Szu-Wen Wang, Jia-Yan Chen, Chih-Chuan Kung, Kuo-Shiang Liao, Chi-Huey Wong

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38011546

Doi: 10.1073/pnas.2314392120

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Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker

Authors: Anika Vear, Claudia Thalmann, Kristina Youngs, Natalie Hannan, Tracey Gaspari, Siew Yeen Chai

Journal: Sci Rep

PubMed ID: 38001104

Doi: 10.1038/s41598-023-44038-1

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Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19

Authors: Tomas O Jensen, Greg A Grandits, Mamta K Jain, Thomas A Murray, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy A Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko

Journal: J Infect Dis

PubMed ID: 37948759

Doi: 10.1093/infdis/jiad446

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Self-Entrapment of Antimicrobial Peptides in Silica Particles for Stable and Effective Antimicrobial Peptide Delivery System

Authors: Mi-Ran Ki, Sung Ho Kim, Tae In Park, Seung Pil Pack

Journal: Int J Mol Sci

PubMed ID: 38003614

Doi: 10.3390/ijms242216423

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Engineering U1-Based Tetracycline-Inducible Riboswitches to Control Gene Expression in Mammals

Authors: Eric Rovira, Beatriz Moreno, Nerea Razquin, Lorea Blázquez, Ruben Hernández-Alcoceba, Puri Fortes, Fernando Pastor

Journal: ACS Nano

PubMed ID: 37971502

Doi: 10.1021/acsnano.3c01994

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Acidic pH or salt treatment can convert soluble antibody aggregates in culture harvest into monomers and improve Protein A chromatography step yield

Authors: Ting Zhang, Bin Li, Wanyuan Dong, Yan Wan, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 37939750

Doi: 10.1016/j.pep.2023.106391

Products & Services: Proteins, Expression, Isolation and Analysis

Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations

Authors: Fiona L Wong, Thomas A Bunch, Victoria C Lepak, Allison L Steedman, Brett A Colson

Journal: J Mol Cell Cardiol

PubMed ID: 38008210

Doi: 10.1016/j.yjmcc.2023.11.010

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Genetic manipulation of giant viruses and their host, Acanthamoeba castellanii

Authors: Nadege Philippe, Avi Shukla, Chantal Abergel, Hugo Bisio

Journal: Nat Protoc

PubMed ID: 37964008

Doi: 10.1038/s41596-023-00910-y

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Structural and biophysical properties of a [4Fe4S] ferredoxin-like protein from Synechocystis sp PCC 6803 with a unique two domain structure

Authors: Effie Kisgeropoulos, Vivek S Bharadwaj, Anastasia Ledinina, Carolyn E Lubner, David W Mulder, Sharon L Smolinski, Marko Boehm, Kirstin Gutekunst, Paul W King, Drazenka Svedruzic

Journal: J Inorg Biochem

PubMed ID: 38008043

Doi: 10.1016/j.jinorgbio.2023.112428

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Sirtuin 3-mediated deacetylation of superoxide dismutase 2 ameliorates sodium fluoride-induced mitochondrial dysfunction in porcine oocytes

Authors: Xin-Yue Qi, Jin-Dong Yuan, Zi-Yu Liu, Xi-Qing Jiang, Qi Zhang, Shan-Long Zhang, Lu Zhao, Ling-Yan Ke, Chen-Yuan Zhang, Yan Li, Lu-Yan Zhang, Qian-Qian Xu, Zhong-Hua Liu, Jing-Tao Sun, Jun-Xue Jin

Journal: Sci Total Environ

PubMed ID: 37944611

Doi: 10.1016/j.scitotenv.2023.168306

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Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite

Authors: Rahul Singh Rawat, Ankit Gupta, Neelam Antil, Sonika Bhatnagar, Monika Singh, Akanksha Rawat, T S Keshava Prasad, Pushkar Sharma

Journal: PLoS Pathog

PubMed ID: 37988347

Doi: 10.1371/journal.ppat.1011770

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Targeting the COMMD4-H2B protein complex in lung cancer

Authors: Ming Tang, Joshua T Burgess, Mark Fisher, Didier Boucher, Emma Bolderson, Neha S Gandhi, Kenneth J O'Byrne, Derek J Richard, Amila Suraweera

Journal: Br J Cancer

PubMed ID: 37914802

Doi: 10.1038/s41416-023-02476-8

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Regioselective Glycosylation of Polyphenols by Family 1 Glycosyltransferases: Experiments and Simulations

Authors: Ruben M de Boer, Dovydas Vaitkus, Kasper Enemark-Rasmussen, Sören Maschmann, David Teze, Ditte H Welner

Journal: ACS Omega

PubMed ID: 38075805

Doi: 10.1021/acsomega.3c08255

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Extracellular electron uptake from a cathode by the lactic acid bacterium

Authors: Sara Tejedor-Sanz, Siliang Li, Biki Bapi Kundu, Caroline M Ajo-Franklin

Journal: Front Microbiol

PubMed ID: 38075918

Doi: 10.3389/fmicb.2023.1298023

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Comparative Computational Analysis of Spike Protein Structural Stability in SARS-CoV-2 Omicron Subvariants

Authors: Anand Balupuri, Jeong-Min Kim, Kwang-Eun Choi, Jin Sun No, Il-Hwan Kim, Jee Eun Rhee, Eun-Jin Kim, Nam Sook Kang

Journal: Int J Mol Sci

PubMed ID: 38003257

Doi: 10.3390/ijms242216069

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The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells

Authors: Jing Cheng, Yutong Wang, Lizheng Yin, Wenzhang Liang, Jing Zhang, Cuiqing Ma, Yu Zhang, Bo Liu, Jiachao Wang, Weiting Zhao, Miao Li, Lin Wei

Journal: MBio

PubMed ID: 37909764

Doi: 10.1128/mbio.01480-23

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IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma

Authors: Junnan Ru, Jiahua Lu, Jiangzhen Ge, Bo Ding, Rong Su, Yifan Jiang, Yujing Sun, Jun Ma, Yu Li, Jingqi Sun, Guangming Xu, Rongliang Tong, Shusen Zheng, Beng Yang, Jian Wu

Journal: Cancer Lett

PubMed ID: 37993085

Doi: 10.1016/j.canlet.2023.216495

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Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis

Authors: Andrew K Lamb, Andres N Fernandez, Abdunaser Eadaim, Katelyn Johnson, Santiago M Di Pietro

Journal: J Cell Biol

PubMed ID: 37966720

Doi: 10.1083/jcb.202306154

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Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

Authors: Haofeng Wang, Qi Yang, Xiaoce Liu, Zili Xu, Maolin Shao, Dongxu Li, Yinkai Duan, Jielin Tang, Xianqiang Yu, Yumin Zhang, Aihua Hao, Yajie Wang, Jie Chen, Chenghao Zhu, Luke Guddat, Hongli Chen, Leike Zhang, Xinwen Chen, Biao Jiang, Lei Sun, Zihe Rao, Haitao Yang

Journal: Nat Commun

PubMed ID: 37990007

Doi: 10.1038/s41467-023-42527-5

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Retraction: Epitopes screening and vaccine molecular design of SADS-CoV based on immunoinformatics

Authors:

Journal: Front Vet Sci

PubMed ID: 38105774

Doi: 10.3389/fvets.2023.1342203

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Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models

Authors: Viviane M Andrade, Igor Maricic, Richa Kalia, Lauren Jachimowicz, Olivia Bedoya, Daniel W Kulp, Laurent Humeau, Trevor R F Smith

Journal: Hum Vaccin Immunother

PubMed ID: 38012018

Doi: 10.1080/21645515.2023.2281733

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Antagonistic conflict between transposon-encoded introns and guide RNAs

Authors: Rimantė Žedaveinytė, Chance Meers, Hoang C Le, Edan E Mortman, Stephen Tang, George D Lampe, Sanjana R Pesari, Diego R Gelsinger, Tanner Wiegand, Samuel H Sternberg

Journal: biorxiv

PubMed ID: 38045383

Doi: 10.1101/2023.11.20.567912

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A Versatile Platform to Generate Prodrugs with Rapid and Precise Albumin Hitchhiking and High Cargo Loading for Tumor-Targeted Chemotherapy

Authors: Jing Li, Huimin Xing, Jie Chen, Hongyu Lu, Ze Tao, Yiran Tao, Yunqing Sun, Tao Su, Xin Li, Huansheng Chang, Shiyuan Chen, Zhuo Chen, Hao Yang, Jingqiu Cheng, Hong Zhu, Xiaofeng Lu

Journal: Small

PubMed ID: 37963821

Doi: 10.1002/smll.202304253

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Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19

Authors: Maya F Amjadi, Maxwell H Parker, Ryan R Adyniec, Zihao Zheng, Alex M Robbins, S Janna Bashar, Michael F Denny, Sara S McCoy, Irene M Ong, Miriam A Shelef

Journal: J Autoimmun

PubMed ID: 37956528

Doi: 10.1016/j.jaut.2023.103132

Products & Services: Proteins, Expression, Isolation and Analysis

Reconstruction of dynamic mammary mini gland in vitro for normal physiology and oncogenesis

Authors: Lei Yuan, Shaofang Xie, Huiru Bai, Xiaoqin Liu, Pei Cai, Jing Lu, Chunhui Wang, Zuobao Lin, Shuying Li, Yajing Guo, Shang Cai

Journal: Nat Methods

PubMed ID: 37919421

Doi: 10.1038/s41592-023-02039-y

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Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding

Authors: Zhi Li , Ning Wu , Jing Wang , Yang Yue , Lihua Geng , Quanbin Zhang

Journal: Br J Pharmacol .

PubMed ID: 37994102

Doi: 10.1111/bph.16288

Products & Services: Proteins, Expression, Isolation and Analysis

Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance

Authors: Yanping Yang, Raymond Louie, Janusz Puc, Yogindra Vedvyas, Yago Alcaina, Irene M Min, Matt Britz, Fabio Luciani, Moonsoo M Jin

Journal: Cancers (Basel)

PubMed ID: 38067255

Doi: 10.3390/cancers15235552

Products & Services: Proteins, Expression, Isolation and Analysis

Regulation of Atg8 membrane deconjugation by cysteine proteases in the malaria parasite Plasmodium berghei

Authors: Akancha Mishra, Aastha Varshney, Satish Mishra

Journal: Cell Mol Life Sci

PubMed ID: 37910326

Doi: 10.1007/s00018-023-05004-2

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Enhancing the Physicochemical Attributes of Dough and Noodles through the Incorporation of Laccase

Authors: Xiaoyu Zhu, Shijin Zhang, Luyao Bian, Juan Shen, Chong Zhang, Sivakumar Manickam, Yang Tao, Zhaoxin Lu

Journal: Foods

PubMed ID: 38002203

Doi: 10.3390/foods12224146

Products & Services: Proteins, Expression, Isolation and Analysis

Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51

Authors: Lei Tao, Yue Zhou, Xiangyu Pan, Yuan Luo, Jiahao Qiu, Xia Zhou, Zhiqian Chen, Yan Li, Lian Xu, Yang Zhou, Zeping Zuo, Chunqi Liu, Liang Wang, Xiaocong Liu, Xinyu Tian, Na Su, Zhengnan Yang, Yu Zhang, Kun Gou, Na Sang, Huan Liu, Jiao Zou, Yuzhou Xiao, Xi Zhong, Jing Xu, Xinyu Yang, Kai Xiao, Yanyang Liu, Shengyong Yang, Yong Peng, Junhong Han, Xiaobo Cen, Yinglan Zhao

Journal: Nat Commun

PubMed ID: 37973845

Doi: 10.1038/s41467-023-42850-x

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Author Correction: A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques

Authors: Ting Bian, Meng Hao, Xiaofan Zhao, Chuanyi Zhao, Gang Luo, Zhendong Zhang, Guangcheng Fu, Lu Yang, Yi Chen, Yudong Wang, Changming Yu, Yilong Yang, Jianmin Li, Wei Chen

Journal: npj Vaccines

PubMed ID: 38017028

Doi: 10.1038/s41541-023-00780-1

Products & Services: Proteins, Expression, Isolation and Analysis

Inflammation primes the kidney for recovery by activating AZIN1 A-to-I editing

Authors: Segewkal Heruye, Jered Myslinski, Chao Zeng, Amy Zollman, Shinichi Makino, Azuma Nanamatsu, Quoseena Mir, Sarath Chandra Janga, Emma H Doud, Michael T Eadon, Bernhard Maier, Michiaki Hamada, Tuan M Tran, Pierre C Dagher, Takashi Hato

Journal: biorxiv

PubMed ID: 37986799

Doi: 10.1101/2023.11.09.566426

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Dual function of Zika virus NS2B-NS3 protease

Authors: Sergey A Shiryaev, Piotr Cieplak, Anton Cheltsov, Robert C Liddington, Alexey V Terskikh

Journal: PLoS Pathog

PubMed ID: 38011215

Doi: 10.1371/journal.ppat.1011795

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Engineering the synthetic β-alanine pathway in Komagataella phaffii for conversion of methanol into 3-hydroxypropionic acid

Authors: Sílvia Àvila-Cabré, Míriam Pérez-Trujillo, Joan Albiol, Pau Ferrer

Journal: Microb Cell Fact

PubMed ID: 37978380

Doi: 10.1186/s12934-023-02241-9

Products & Services: Proteins, Expression, Isolation and Analysis

Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight

Authors: Min-Zhi Chen, Ping Xie, Xiao-Chang Wu, Zhen-Hua Tan, Hai Qian, Zhi-Hong Ma, Xing Yao

Journal: Hepatobiliary Pancreat Dis Int

PubMed ID: 38040523

Doi: 10.1016/j.hbpd.2023.11.007

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A Subunit Vaccine Candidate Composed of Mpox Virus A29L, M1R, A35R, and B6R Elicits Robust Immune Response in Mice

Authors: Xuetao Yang , Xidan Yang , Shouwen Du , Congxia Hu , Xiu Yang , Xingyun Wang , Xing Hu , Nino Rcheulishvili , Peng George Wang and Jihui Lin

Journal: Vaccines.

Doi: 10.3390/vaccines11091420

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Fluorescence-quenching lateral flow immunoassay for “turn-on” and sensitive detection of anti-SARS-CoV-2 neutralizing antibodies in human serum

Authors: Lun Bian , Qiangqiang Fu , Zhuoheng Gan , Ze Wu , Yuchen Song , Yufeng Xiong , Fang Hu, Lei Zheng

Journal: Adv Sci (Weinh) .

PubMed ID: 38032112

Doi: 10.1002/advs.202305774

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Functional Characterization of Novel Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

Authors: Idris Mohammed, Senthil Selvaraj, Wesam S Ahmed, Tara Al-Barazenji, Ayat S Hammad, Hajar Dauleh, Luis R Saraiva, Mashael Al-Shafai, Khalid Hussain

Journal: Int J Mol Sci

PubMed ID: 38003551

Doi: 10.3390/ijms242216361

Products & Services: Proteins, Expression, Isolation and Analysis

Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors

Authors: Mikhail Rudinskiy, Maria Pons-Vizcarra, Tatiana Soldà, Ilaria Fregno, Timothy Jan Bergmann, Ana Ruano, Aida Delgado, Sara Morales, Xavier Barril, Manolo Bellotto, Elena Cubero, Ana María García-Collazo, Natalia Pérez-Carmona, Maurizio Molinari

Journal: PLoS ONE

PubMed ID: 38019733

Doi: 10.1371/journal.pone.0294437

Products & Services: Proteins, Expression, Isolation and Analysis

Galectin-14 promotes hepatocellular carcinoma tumor growth enhancing heparan sulfate proteoglycan modification

Authors: Liming Gou, Gang Yang, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Jin Huang, Wei Gao

Journal: J Biomed Res

PubMed ID: 37977559

Doi: 10.7555/JBR.37.20230085

Products & Services: Proteins, Expression, Isolation and Analysis

EBF2 Links KMT2D-Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN

Authors: Bing Yao, Mengying Xing, Shixin Meng, Shang Li, Jingwan Zhou, Ming Zhang, Chen Yang, Shuang Qu, Yucui Jin, Hongyan Yuan, Ke Zen, Changyan Ma

Journal: Adv Sci (Weinh)

PubMed ID: 38015024

Doi: 10.1002/advs.202302037

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A nanoparticle vaccine displaying the ookinete PSOP25 antigen elicits transmission-blocking antibody response against Plasmodium berghei

Authors: Guixiang Yao, Hui Min, Xinxin Yu, Fei Liu, Liwang Cui, Yaming Cao

Journal: Parasit Vectors

PubMed ID: 37932796

Doi: 10.1186/s13071-023-06020-8

Products & Services: Proteins, Expression, Isolation and Analysis

Suburban Population of Bobcats (Lynx rufus) in Connecticut, USA, Tested Negative for SARS-CoV-2, November 2021-February 2022

Authors: Maureen Sims, Zeinab Helal, Milton Levin, Tracy Rittenhouse, Jason Hawley, Guillermo R Risatti

Journal: J Wildl Dis

PubMed ID: 37924242

Doi: 10.7589/JWD-D-23-00054

Products & Services: Proteins, Expression, Isolation and Analysis

Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron

Authors: Daniela Bottero, Erika Rudi, Pablo Martin Aispuro, Eugenia Zurita, Emilia Gaillard, Maria M Gonzalez Lopez Ledesma, Juan Malito, Matthew Stuible, Nicolas Ambrosis, Yves Durocher, Andrea V Gamarnik, Andrés Wigdorovitz, Daniela Hozbor

Journal: Front Immunol

PubMed ID: 38022542

Doi: 10.3389/fimmu.2023.1271209

Products & Services: Proteins, Expression, Isolation and Analysis

Dynamics of Serum-Neutralizing Antibody Responses in Vaccinees through Multiple Doses of the BNT162b2 Vaccine

Authors: Jared Sheehan, Caleb M Ardizzone, Mayank Khanna, Amber J Trauth, Michael E Hagensee, Alistair J Ramsay

Journal: Vaccines (Basel)

PubMed ID: 38006052

Doi: 10.3390/vaccines11111720

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Cytoplasmic production of Fabs in chemically defined media in fed-batch fermentation

Authors: Angel Castillo-Corujo, Mirva J Saaranen, Lloyd W Ruddock

Journal: Protein Expr Purif

PubMed ID: 37979630

Doi: 10.1016/j.pep.2023.106404

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular Analysis of a Congenital Myasthenic Syndrome Due to a Pathogenic Variant Affecting the C-Terminus of ColQ

Authors: Susie Barbeau, Fannie Semprez, Alexandre Dobbertin, Laurine Merriadec, Florine Roussange, Bruno Eymard, Damien Sternberg, Emmanuel Fournier, Hanice Karasoy, Cécile Martinat, Claire Legay

Journal: Int J Mol Sci

PubMed ID: 38003406

Doi: 10.3390/ijms242216217

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Interplay between stochastic enzyme activity and microtubule stability drives detyrosination enrichment on microtubule subsets

Authors: Qing Tang, Sebastian Sensale, Charles Bond, Jiazheng Xing, Andy Qiao, Siewert Hugelier, Arian Arab, Gaurav Arya, Melike Lakadamyali

Journal: Curr Biol

PubMed ID: 37979580

Doi: 10.1016/j.cub.2023.10.068

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DNA Condensation by Peptide-Conjugated PAMAM Dendrimers Influence of Peptide Charge

Authors: Corinna Dannert, Ingrid Mardal, Rahmi Lale, Bjørn Torger Stokke, Rita S Dias

Journal: ACS Omega

PubMed ID: 38046290

Doi: 10.1021/acsomega.3c05140

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The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription

Authors: Jordan Jennings, Harrison Bracey, Danny T Nguyen, Rishav Dasgupta, Alondra Vázquez Rivera, Nicolas Sluis-Cremer, Jiong Shi, Christopher Aiken

Journal: biorxiv

PubMed ID: 37986899

Doi: 10.1101/2023.11.08.566350

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Protein-Phenol Adducts in Meat Proteins: A Molecular Probe Technology Study

Authors: Fenhong Yang, Yingying Zhu, Xiaohan Li, Fengtao Xiang, Moru Deng, Wei Zhang, Wei Song, Hao Sun, Changbo Tang

Journal: Foods

PubMed ID: 38231694

Doi: 10.3390/foods12234225

Products & Services: Proteins, Expression, Isolation and Analysis

Laminin β4 is a constituent of the cutaneous basement membrane zone and additional autoantigen of anti-p200 pemphigoid

Authors: Stephanie Goletz, Manuela Pigors, Tina Rastegar Lari, Christoph M Hammers, Yao Wang, Shirin Emtenani, Monique Aumailley, Maike M Holtsche, Felix H Stang, Imke Weyers, Inke R König, Cristina Has, Christiane Radzimski, Lars Komorowski, Detlef Zillikens, Enno Schmidt

Journal: J Am Acad Dermatol

PubMed ID: 37992812

Doi: 10.1016/j.jaad.2023.11.014

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Identification of mouse CD4 T cell epitopes in SARS-CoV-2 BA1 spike and nucleocapsid for use in peptide:MHCII tetramers

Authors: Laura Bricio Moreno, Juliana Barreto de Albuquerque, Jake M Neary, Thao Nguyen, Kathryn M Hastie, Sara Landeras-Bueno, Chitra Hariharan, Anusha Nathan, Matthew A Getz, Alton C Gayton, Ashok Khatri, Gaurav D Gaiha, Erica Ollmann Saphire, Andrew D Luster, James J Moon

Journal: biorxiv

PubMed ID: 38014059

Doi: 10.1101/2023.11.16.566918

Products & Services: Proteins, Expression, Isolation and Analysis

Chemical protein synthesis enabled engineering of saccharide oxidative cleavage activity in artificial metalloenzymes

Authors: Jindi Luo, Chunmao He

Journal: Int J Biol Macromol

PubMed ID: 38000595

Doi: 10.1016/j.ijbiomac.2023.128083

Products & Services: Proteins, Expression, Isolation and Analysis

Cold atmospheric plasma can effectively disinfect SARS-CoV-2 in the wastewater

Authors: Hongbo Qin, Hengju Qiu, Ke Liu, Bixia Hong, Yuchen Liu, Chun Li, Mengzhe Li, Xiaoping An, Lihua Song, Eric Robert, Yigang Tong, Huahao Fan, Ruixue Wang

Journal: Exploration (Beijing)

PubMed ID: 38939868

Doi: 10.1002/EXP.20230012

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Human mesenchymal stem cells derived from adipose tissue showed a more robust effect than those from the umbilical cord in promoting corneal graft survival by suppressing lymphangiogenesis

Authors: Huanmin Kang, Jianing Feng, Yingqian Peng, Yingyi Liu, Yalei Yang, Ying Wu, Jian Huang, Ying Jie, Baihua Chen, Yan He

Journal: Stem Cell Res Ther

PubMed ID: 37957770

Doi: 10.1186/s13287-023-03559-2

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An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

Authors: Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V Rogov, Ramachandra M Bhaskara, Stefan Müller

Journal: Cell Rep

PubMed ID: 37999976

Doi: 10.1016/j.celrep.2023.113484

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Dual-systems models of the genetic architecture of impulsive personality traits: neurogenetic evidence of distinct but related factors

Authors: Alex P Miller, Ian R Gizer

Journal: Psychol Med

PubMed ID: 38016992

Doi: 10.1017/S0033291723003367

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Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway

Authors: Karim H Saba, Valeria Difilippo, Michal Kovac, Louise Cornmark, Linda Magnusson, Jenny Nilsson, Hilda van den Bos, Diana Cj Spierings, Mahtab Bidgoli, Tord Jonson, Vaiyapuri P Sumathi, Otte Brosjö, Johan Staaf, Floris Foijer, Emelie Styring, Michaela Nathrath, Daniel Baumhoer, Karolin H Nord

Journal: J Pathol

PubMed ID: 38010733

Doi: 10.1002/path.6219

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Varying the RGD concentration on a hyaluronic acid hydrogel influences dormancy versus proliferation in brain metastatic breast cancer cells

Authors: Kasra Goodarzi, Rachel Lane, Shreyas S Rao

Journal: J Biomed Mater Res A

PubMed ID: 38018303

Doi: 10.1002/jbm.a.37651

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