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Tumor-Reactive CD8+ T Cells Enter a TCF1+PD-1- Dysfunctional State

Authors: Jessica J Roetman, Megan M Erwin, Michael W Rudloff, Natalie R Favret, Carlos R Detrés Román, Minna K I Apostolova, Kristen A Murray, Ting-Fang Lee, Youngmin A Lee, Mary Philip

Journal: Cancer Immunol Res

PubMed ID: 37844197

Doi: 10.1158/2326-6066.CIR-22-0939

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Inhalation of taraxasterol loaded mixed micelles for the treatment of idiopathic pulmonary fibrosis

Authors: Tong Zhang , Chao Sun , Shubin Yang , Zimin Cai , Sifeng Zhu , Wendian Liu , Yun Luan , Cheng Wang

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2023.109248

Products & Services: Recombinant Proteins

Discrimination of Disaccharide Isomers of Different Glycosidic Linkages Using a Modified MspA Nanopore

Authors: Shanyu Zhang , Zhenyuan Cao , Pingping Fan , Wen Sun , Yunqi Xiao , Panke Zhang , Yuqin Wang , Shuo Huang

Journal: Angew Chem Int Ed Engl .

PubMed ID: 38116834

Doi: 10.1002/anie.202316766

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NITR12+ NK Cells Release Perforin to Mediate IgMhi B Cell Killing in Turbot (Scophthalmus maximus)

Authors: Wei Wang, Ying Wang, Jin Yang, Qin Liu, Yuanxing Zhang, Dahai Yang

Journal: J Immunol

PubMed ID: 37843506

Doi: 10.4049/jimmunol.2300281

Products & Services: Proteins, Expression, Isolation and Analysis

Development of Self-Assembled Protein Nanocage Spatially Functionalized with HA Stalk as a Broadly Cross-Reactive Influenza Vaccine Platform

Authors: Jaeyoung Park, Julie A Champion

Journal: ACS Nano

PubMed ID: 38084728

Doi: 10.1021/acsnano.3c07669

Products & Services: Molecular Biology Reagents

The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

Authors: Gerard J Chu, Charles G Bailey, Rajini Nagarajah, Sharon M Sagnella, Stephen Adelstein, John E J Rasko

Journal: Cancer Cell Int

PubMed ID: 38105188

Doi: 10.1186/s12935-023-03171-7

Products & Services: Proteins, Expression, Isolation and Analysis

Localization confirms EnApiAP2 protein encoded by as a nuclear protein in

Authors: Weimin Cai, Qianqian Feng, Liyue Wang, Shijie Su, Zhaofeng Hou, Dandan Liu, Xilong Kang, Jinjun Xu, Zhiming Pan, Jianping Tao

Journal: Front Cell Infect Microbiol

PubMed ID: 38116134

Doi: 10.3389/fcimb.2023.1305727

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Overexpression of endogenous multi-copper oxidases mcoA and mcoC in Rhodococcus jostii RHA1 enhances lignin bioconversion to 2,4-pyridine-dicarboxylic acid

Authors: Goran M M Rashid, Victoria Sodré, Jia Luo, Timothy D H Bugg

Journal: Biotechnol Bioeng

PubMed ID: 38079064

Doi: 10.1002/bit.28620

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A bioengineered anti-VEGF protein with high affinity and high concentration for intravitreal treatment of wet age-related macular degeneration

Authors: Chengnan Huang, Yuelin Wang, Jinliang Huang, Huiqin Liu, Zhidong Chen, Yang Jiang, Youxin Chen, Feng Qian

Journal: Bioeng Transl Med

PubMed ID: 38435828

Doi: 10.1002/btm2.10632

Products & Services: Recombinant Proteins

Pal power: Demonstration of the functional association of the Helicobacter pylori flagellar motor with peptidoglycan-associated lipoprotein (Pal) and its preliminary crystallographic analysis

Authors: Xiaotian Zhou, Mohammad M Rahman, Sharmin Q Bonny, Yue Xin, Nikki Liddelow, Mohammad F Khan, Alexandra Tikhomirova, Jihane Homman-Ludiye, Anna Roujeinikova

Journal: Biosci Trends

PubMed ID: 38072447

Doi: 10.5582/bst.2023.01278

Products & Services: Proteins, Expression, Isolation and Analysis

IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight

Authors: Chunfang Gu, Xingyao Li, Guangning Zong, Huanchen Wang, Stephen B Shears

Journal: Adv Biol Regul

PubMed ID: 38064879

Doi: 10.1016/j.jbior.2023.101002

Products & Services: Proteins, Expression, Isolation and Analysis

A new gene family (BAPs) of bracovirus induces apoptosis of host hemocytes

Authors: Ze-Hua Wang, Xi-Qian Ye, Xiao-Tong Wu, Zhi-Zhi Wang, Jian-Hua Huang, Xue-Xin Chen

Journal: Virulence

PubMed ID: 36694288

Doi: 10.1080/21505594.2023.2171691

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Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis

Authors: Ting Zhou, Zhiqiang Ke, Qianqian Ma, Jiani Xiang, Meng Gao, Yongqi Huang, Xiyao Cheng, Zhengding Su

Journal: Sci Rep

PubMed ID: 38081879

Doi: 10.1038/s41598-023-47808-z

Products & Services: Proteins, Expression, Isolation and Analysis

Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway

Authors: Sheena Vasquez, Melissa D Marquez, Edward J Brignole, Amanda Vo, Sunnie Kong, Christopher Park, Deborah L Perlstein, Catherine L Drennan

Journal: Commun Biol

PubMed ID: 38110506

Doi: 10.1038/s42003-023-05579-3

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Conserved Residues at the Mtr4 C-Terminus Coordinate Helicase Activity and Exosome Interactions

Authors: Matthew K Yim, Catherine J Stuart, Markell I Pond, Ambro van Hoof, Sean J Johnson

Journal: Biochemistry

PubMed ID: 38085597

Doi: 10.1021/acs.biochem.3c00401

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A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV‐2 in Cells

Authors: Xiaohong Sang, Juan Wang, Jiao Zhou, Yan Xu, Jing An, Arieh Warshel, Ziwei Huang

Journal: J Am Chem Soc

PubMed ID: 38064654

Doi: 10.1021/jacs.3c12678.

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Regional abundances of binder of sperm (BSP) proteins are negatively associated with the quality of frozen-thawed bovine spermatozoa

Authors: Edgar A Diaz-Miranda, Lauren E Hamilton, Michal Zigo, Lindsey Fallon, M Sofia Ortega, Mayra E Ortiz D'Avila Assumpção, José D Guimarães, Peter Sutovsky

Journal: Reproduction

PubMed ID: 37874784

Doi: 10.1530/REP-23-0305

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Covalent PROTAC design method based on a sulfonyl pyridone probe

Authors: Qinhong Luo , Yaqi Wang , Zhanfeng Hou , Huiting Liang , Licheng Tu , Yun Xing , Chuan Wan , Jianbo Liu , Rui Wang , Lizhi Zhu , Wei Han , Jianlong Wu , Fei Lu , Feng Yin , Zigang Li

Journal: Chem Commun (Camb) .

PubMed ID: 38054347

Doi: 10.1039/d3cc05127g

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Immunorecognition of Streptococcus mutans secreted proteins protects against caries by limiting tooth adhesion

Authors: Omer Bender, Jessica Khoury, Gal Hirsch, Evgeny Weinberg, Naor Sagy, Shani Buller, Shiri Lapides-Levy, Sigalit Blumer, Daniel Z Bar

Journal: J Dent

PubMed ID: 38101504

Doi: 10.1016/j.jdent.2023.104805

Products & Services: Proteins, Expression, Isolation and Analysis

Reproduction of Varroa destructor depends on well-timed host cell recapping and seasonal patterns

Authors: Martin Gabel, Ricarda Scheiner, Ingolf Steffan-Dewenter, Ralph Büchler

Journal: Sci Rep

PubMed ID: 38110489

Doi: 10.1038/s41598-023-49688-9

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered Antiviral Sensor Targets Infected Mosquitoes

Authors: Elena Dalla Benetta, Adam J López-Denman, Hsing-Han Li, Reem A Masri, Daniel J Brogan, Michelle Bui, Ting Yang, Ming Li, Michael Dunn, Melissa J Klein, Sarah Jackson, Kyle Catalan, Kim R Blasdell, Priscilla Tng, Igor Antoshechkin, Luke S Alphey, Prasad N Paradkar, Omar S Akbari

Journal: CRISPR J

PubMed ID: 38108518

Doi: 10.1089/crispr.2023.0056

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Green synthesis of silver nanoparticles by using Allium sativum extract and evaluation of their electrical activities in bio-electrochemical cell

Authors: Md Ohiduzzaman, M N I Khan, K A Khan, Bithi Paul

Journal: Nanotechnology

PubMed ID: 38029451

Doi: 10.1088/1361-6528/ad10e4

Products & Services: Proteins, Expression, Isolation and Analysis

SRSF10 facilitates HCC growth and metastasis by suppressing CD8T cell infiltration and targeting SRSF10 enhances anti-PD-L1 therapy

Authors: Xiangyuan Luo, Zerui Zhang, Siwen Li, Yijun Wang, Mengyu Sun, Dian Hu, Junqing Jiang, Yufei Wang, Xiaoyu Ji, Xiaoping Chen, Bixiang Zhang, Huifang Liang, Yiwei Li, Bifeng Liu, Xiao Xu, Shuai Wang, Shengjun Xu, Yongzhan Nie, Kaichun Wu, Daiming Fan, Danfei Liu, Wenjie Huang, Limin Xia

Journal: Int Immunopharmacol

PubMed ID: 38113691

Doi: 10.1016/j.intimp.2023.111376

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Global gene regulatory network underlying miR165a in Arabidopsis shoot apical meristem

Authors: Sonali Sinha, Sudeep Sahadevan, Carolyn Ohno, Hasthi Ram, Marcus G Heisler

Journal: Sci Rep

PubMed ID: 38097643

Doi: 10.1038/s41598-023-49093-2

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Characterization of human XPD helicase activity with Single Molecule Magnetic Tweezers

Authors: Chunfeng Mao, Maria Mills

Journal: Biophys J

PubMed ID: 38111195

Doi: 10.1016/j.bpj.2023.12.014

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CRISPR loss of function screening to identify genes involved in human primordial germ cell-like cell development

Authors: Young Sun Hwang, Yasunari Seita, M Andrés Blanco, Kotaro Sasaki

Journal: PLoS Genet

PubMed ID: 38091369

Doi: 10.1371/journal.pgen.1011080

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Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2

Authors: Xia Rao, Runchu Zhao, Zhou Tong, Shuxin Guo, Weiyu Peng, Kefang Liu, Shihua Li, Lili Wu, Jianyu Tong, Yan Chai, Pu Han, Feiran Wang, Peng Jia, Zhaohui Li, Xin Zhao, Dedong Li, Rong Zhang, Xue Zhang, Weiwei Zou, Weiwei Li, Qihui Wang, George Fu Gao, Yan Wu, Lianpan Dai, Feng Gao

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38109549

Doi: 10.1073/pnas.2314193120

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The 6-Month Antibody Durability of Heterologous Convidecia Plus CoronaVac and Homologous CoronaVac Immunizations in People Aged 18-59 Years and over 60 Years Based on Two Randomized Controlled Trials in China

Authors: Hudachuan Jiang, Pengfei Jin, Xiling Guo, Jiahong Zhu, Xue Wang, Peng Wan, Jingxuan Wan, Jingxian Liu, Jingxin Li, Fengcai Zhu

Journal: Vaccines (Basel)

PubMed ID: 38140219

Doi: 10.3390/vaccines11121815

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Host IPR channels are dispensable for rotavirus Ca signaling but critical for intercellular Ca waves that prime uninfected cells for rapid virus spread

Authors: Jacob L Perry, Francesca J Scribano, John T Gebert, Kristen A Engevik, Jenna M Ellis, Joseph M Hyser

Journal: MBio

PubMed ID: 38112482

Doi: 10.1128/mbio.02145-23

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The Raf-like MAPKKKs STY8, STY17, and STY46 negatively regulate Botrytis cinerea resistance by limiting MKK7 protein accumulation in Arabidopsis

Authors: Lijuan Chen, Jiahui Xiao, You Li, Yuxiao Song, Jun Liu, Qi Zhou, Ting Sun, Hong-Bin Wang, Bing Liu

Journal: Plant J

PubMed ID: 38059690

Doi: 10.1111/tpj.16578

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Bisphenol A induces non-alcoholic fatty liver disease by promoting the O-GlcNAcylation of NLRP3

Authors: Yonghong Zhang, Shujuan Han, Tian Li, Li Zhu, Feng Wei

Journal: Arch Physiol Biochem

PubMed ID: 38038745

Doi: 10.1080/13813455.2023.2288533

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Manganese@Albumin Nanocomplex and Its Assembled Nanowire Activate TLR4-Dependent Signaling Cascades of Macrophages

Authors: Shuodan Huang, Yan Gao, Huiying Li, Ruoran Wang, Xiaomei Zhang, Xiaoyu Wang, Di Huang, Linxuan Zhang, Hélder A Santos, Zhenyu Yin, Bing Xia

Journal: Adv Mater

PubMed ID: 37994277

Doi: 10.1002/adma.202310979

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Effect of Nk-lysin peptides on bacterial growth, MIC, antimicrobial resistance, and viral activities

Authors: Haitham A Yacoub, Maged Mostafa Mahmoud, Ahmed M Al-Hejin, Turki S Abujamel, Shams Tabrez, Sherif Abd-Elmaksoud

Journal: Anim Biotechnol

PubMed ID: 38100547

Doi: 10.1080/10495398.2023.2290520

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Propagation of conformational instability in FK506-binding protein FKBP12

Authors: David M LeMaster, Qamar Bashir, Griselda Hernández

Journal: Biochim Biophys Acta Proteins Proteom

PubMed ID: 38142946

Doi: 10.1016/j.bbapap.2023.140990

Products & Services: Proteins, Expression, Isolation and Analysis

Multivalent nanobody-based sandwich enzyme-linked immunosorbent assay for sensitive detection of porcine reproductive and respiratory syndrome virus

Authors: Mingxia Sun, Yue Sun, Yongbo Yang, Man Zhao, Dan Cao, Minmin Zhang, Dasong Xia, Tao Wang, Yanfei Gao, Shanghui Wang, Haiwei Wang, Xuehui Cai, Tongqing An

Journal: Int J Biol Macromol

PubMed ID: 38143067

Doi: 10.1016/j.ijbiomac.2023.128896

Products & Services: Proteins, Expression, Isolation and Analysis

MAT2A inhibition suppresses inflammation in -infected human gingival fibroblasts

Authors: Lishan Jiang, Jingwen Li, Kun Ji, Lang Lei, Houxuan Li

Journal: J Oral Microbiol

PubMed ID: 38130504

Doi: 10.1080/20002297.2023.2292375

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ACE2-Fc and DPP4-Fc decoy receptors against SARS-CoV-2 and MERS-CoV variants: a quick therapeutic option for current and future coronaviruses outbreaks

Authors: Mohamed A Alfaleh, Reem M Alsulaiman, Sarah A Almahboub, Leena Nezamuldeen, Ayat Zawawi, Najwa D Aljehani, Muhammad Yasir, Rwaa H Abdulal, Rami Alkhaldi, Assala Helal, Sawsan S Alamri, Jana Malki, Rowa Y Alhabbab, Turki S Abujamel, Nabil A Alhakamy, Aisha Alnami, Abdullah Algaissi, Mazen Hassanain, Anwar M Hashem

Journal: Antib Ther

PubMed ID: 38371953

Doi: 10.1093/abt/tbad030

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Safinamide alleviates hyperalgesia via inhibiting hyperexcitability of DRG neurons in a mouse model of Parkinson's disease

Authors: Li-Ge Zhang, Jing Cheng, Meng-Qi An, Cheng-Jie Li, Li-Guo Dong, Jian-Min Wang, Chun-Feng Liu, Fen Wang, Cheng-Jie Mao

Journal: Behav Brain Res

PubMed ID: 38042302

Doi: 10.1016/j.bbr.2023.114787

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A nanobody inhibiting porcine reproductive and respiratory syndrome virus replication via blocking self-interaction of viral nucleocapsid protein

Authors: Hong Duan, Xu Chen, Ziwei Zhang, Zhijie Zhang, Zhihan Li, Xinjie Wang, Jiakai Zhao, Yuchen Nan, Baoyuan Liu, Angke Zhang, Yani Sun, Qin Zhao

Journal: J Virol

PubMed ID: 38084961

Doi: 10.1128/jvi.01319-23

Products & Services: Proteins, Expression, Isolation and Analysis

Association of LOX gene G473A polymorphism with the occurrence of allergic rhinitis and efficacy of montelukast sodium in children

Authors: Xikun Yao, Yan Liu, Hong Jiao, Wenjie Ma, Minliang Chen

Journal: Cell Cycle

PubMed ID: 38009683

Doi: 10.1080/15384101.2023.2286802

Products & Services: Proteins, Expression, Isolation and Analysis

MscI restriction enzyme cooperating recombinase-aided isothermal amplification for the ultrasensitive and rapid detection of low-abundance EGFR mutations on microfluidic chip

Authors: Shiqi Xu, Xinjie Wang, Chengyuan Wu, Xueting Zhu, Xinyi Deng, Yue Wu, Ming Liu, Xingxu Huang, Lina Wu, He Huang

Journal: Biosens Bioelectron

PubMed ID: 38134625

Doi: 10.1016/j.bios.2023.115925

Products & Services: Proteins, Expression, Isolation and Analysis

Novel role of peptidoglycan recognition protein 2 in activating NOD2-NFκB inflammatory axis in coronary artery disease

Authors: Pratitusti Basu, Apabrita Ayan Das, Khawer N Siddiqui, Prakas C Mondal, Arun Bandyopadhyay

Journal: Atherosclerosis

PubMed ID: 38277990

Doi: 10.1016/j.atherosclerosis.2023.117436

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The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

Authors: Meng-Kai Ge, Cheng Zhang, Na Zhang, Ping He, Hai-Yan Cai, Song Li, Shuai Wu, Xi-Li Chu, Yu-Xue Zhang, Hong-Ming Ma, Li Xia, Shuo Yang, Jian-Xiu Yu, Shi-Ying Yao, Xiao-Long Zhou, Bing Su, Guo-Qiang Chen, Shao-Ming Shen

Journal: Cell Metabolism

PubMed ID: 37979583

Doi: doi.org/10.1016/j.cmet.2023.10.016

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of as a novel regulator of carfilzomib resistance in multiple myeloma

Authors: Jie Zhao, Xuantao Yang, Haixi Zhang, Xuezhong Gu

Journal: Oncol Res

PubMed ID: 38186567

Doi: 10.32604/or.2023.030770

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Engineering to produce -muconic acid from biomass aromatics

Authors: Avery C Vilbert, Wayne S Kontur, Derek Gille, Daniel R Noguera, Timothy J Donohue

Journal: Appl Environ Microbiol

PubMed ID: 38117061

Doi: 10.1128/aem.01660-23

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Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8 T cells in persons with previous COVID-19

Authors: Emily S Ford, Koshlan Mayer-Blackwell, Lichen Jing, Kerry J Laing, Anton M Sholukh, Russell St Germain, Emily L Bossard, Hong Xie, Thomas H Pulliam, Saumya Jani, Stacy Selke, Carlissa J Burrow, Christopher L McClurkan, Anna Wald, Alexander L Greninger, Michael R Holbrook, Brett Eaton, Elizabeth Eudy, Michael Murphy, Elena Postnikova, Harlan S Robins, Rebecca Elyanow, Rachel M Gittelman, Matyas Ecsedi, Elise Wilcox, Aude G Chapuis, Andrew Fiore-Gartland, David M Koelle

Journal: Nat Immunol

PubMed ID: 38057617

Doi: 10.1038/s41590-023-01692-x

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A Replication-Competent Retroviral Vector Expressing the HERV-W Envelope Glycoprotein is a Potential Tool for Cancer Gene Therapy

Authors: Byoung Kwon Kang, Yong-Tae Jung

Journal: J Microbiol Biotechnol

PubMed ID: 38247210

Doi: 10.4014/jmb.2309.09022

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Flagellar hook protein FlgE promotes macrophage activation and atherosclerosis by targeting ATP5B

Authors: Yuanyuan Li, Min Zhang, Yanmeng Li, Ying Shen, Xiaoping Wang, Xiaolu Li, Yiqiang Wang, Tao Yu, Jie Lv, Yan Qin

Journal: Atherosclerosis

PubMed ID: 38278062

Doi: 10.1016/j.atherosclerosis.2023.117429

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A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine

Authors: Wenming Liu , Hengchun Li , Bo Liu , Tianxing Lv , Chenchen Yang , Si Chen , Liqiang Feng , Liangxue Lai , Ziyuan Duan , Xinwen Chen , Pingchao Li , Suhua Guan , Ling Chen

Journal: Emerg Microbes Infect .

PubMed ID: 37401832

Doi: 10.1080/22221751.2023.2233643

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Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport

Authors: Bin Pang , Leiye Yu , Tong Li , Haizhan Jiao , Xiaomei Wu , Jinxin Wang , Ruiping He , Yurou Zhang , Juan Wang , Hongli Hu , Wei Dai , Li Chen , Ruobing Ren

Journal: Cell Res .

PubMed ID: 38123824

Doi: 10.1038/s41422-023-00908-x

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Influence of a D-enantiomeric peptide on the anticorrosion ability of titanium with different surface roughness against Streptococcus mutans biofilms

Authors: Dan Wang, Jian Yu, He Liu, Tian Zhang, Evan F Haney, Robert E W Hancock, Lin Peng, Ya Shen

Journal: J Dent

PubMed ID: 37944630

Doi: 10.1016/j.jdent.2023.104777

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Development of automated microfluidic immunoassays for the detection of SARS-CoV-2 antibodies and antigen

Authors: Linwood Johnson, Maggie L Bartlett, Francisco Ramirez, Christopher D Heger, Darci R Smith

Journal: J Immunol Methods

PubMed ID: 38040191

Doi: 10.1016/j.jim.2023.113586

Products & Services: Proteins, Expression, Isolation and Analysis

A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases

Authors: Nicholas W Ashton, Nancy Jaiswal, Natália Cestari Moreno, Irina V Semenova, Dana A D'Orlando, Marcela Teatin Latancia, Justyna McIntyre, Roger Woodgate, Irina Bezsonova

Journal: J Mol Biol

PubMed ID: 37935254

Doi: 10.1016/j.jmb.2023.168353

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Extramedullary hematopoiesis contributes to enhanced erythropoiesis during pregnancy via TGF-β signaling

Authors: Yao Fu, Zhengjuan Li, Wen Lin, Jingxin Yao, Xiang Jiang, Qun Shu, Xiaoyuan Mao, Jiaoqin Tu, Xinyuan Liang, Liping Li

Journal: Front Immunol

PubMed ID: 38045690

Doi: 10.3389/fimmu.2023.1295717

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2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition

Authors: Marios Gavriil, Marco Proietto, Nicole Paczia, Aurelien Ginolhac, Rashi Halder, Elena Valceschini, Thomas Sauter, Carole L Linster, Lasse Sinkkonen

Journal: Life Sci Alliance

PubMed ID: 38011998

Doi: 10.26508/lsa.202302333

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Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Authors: Qi Tang, Hassan H Fakih, Mohammad Zain Ui Abideen, Samuel R Hildebrand, Khashayar Afshari, Katherine Y Gross, Jacquelyn Sousa, Allison S Maebius, Christina Bartholdy, Pia Pernille Søgaard, Malene Jackerott, Vignesh Hariharan, Ashley Summers, Xueli Fan, Ken Okamura, Kathryn R Monopoli, David A Cooper, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, Raymond C Furgal, Karen Dresser, Sarah J Winter, Annabelle Biscans, Jane Chuprin, Nazgol-Sadat Haddadi, Shany Sherman, Ümmügülsüm Yıldız-Altay, Mehdi Rashighi, Jillian M Richmond, Claire Bouix-Peter, Carine Blanchard, Adam Clauss, Julia F Alterman, Anastasia Khvorova, John E Harris

Journal: Nat Commun

PubMed ID: 37925520

Doi: 10.1038/s41467-023-42714-4

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Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex

Authors: Matthias Breindl, Dominika Spitzer, Rūta Gerasimaitė, Visvaldas Kairys, Thomas Schubert, Ramona Henfling, Uwe Schwartz, Gražvydas Lukinavičius, Laura Manelytė

Journal: Nucleic Acids Res

PubMed ID: 38000389

Doi: 10.1093/nar/gkad1096

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A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response

Authors: Bella M Ben-Oz, Feras E Machour, Marian Nicola, Amir Argoetti, Galia Polyak, Rawad Hanna, Oded Kleifeld, Yael Mandel-Gutfreund, Nabieh Ayoub

Journal: Nat Commun

PubMed ID: 37993446

Doi: 10.1038/s41467-023-43495-6

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Linear motif specificity in signaling through p38α and ERK2 mitogen-activated protein kinases

Authors: Jaylissa Torres Robles, Hua Jane Lou, Guangda Shi, Pauline Lining Pan, Benjamin E Turk

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37988460

Doi: 10.1073/pnas.2316599120

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Expression and characterization of novel chimeric endolysin CHAPk-SH3bk against biofilm-forming methicillin-resistant Staphylococcus aureus

Authors: Manisha Behera, Gagandeep Singh, Ashutosh Vats, Mayank Roshan, Devika Gautam, Chanchal Rana, Rajesh Kumar Kesharwani, Sachinandan De, Soma M Ghorai

Journal: Int J Biol Macromol

PubMed ID: 37944719

Doi: 10.1016/j.ijbiomac.2023.127969

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A sensitive luciferase reporter assay for the detection of infectious African swine fever virus

Authors: Kemal Mehinagic, Matthias Liniger, Maksym Samoilenko, Nick Soltermann, Markus Gerber, Nicolas Ruggli

Journal: J Virol Methods

PubMed ID: 37989458

Doi: 10.1016/j.jviromet.2023.114854

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Engineering self-deliverable ribonucleoproteins for genome editing in the brain

Authors: Kai Chen, Elizabeth C Stahl, Min Hyung Kang, Bryant Xu, Ryan Allen, Marena Trinidad, Jennifer A Doudna

Journal: biorxiv

PubMed ID: 38014180

Doi: 10.1101/2023.11.15.567251

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Insights into Molecular Diversity within the FET Family: Unraveling Phase Separation of the N-Terminal Low Complexity Domain from RNA-Binding Protein EWS

Authors: Courtney N Johnson, Kandarp A Sojitra, Erich J Sohn, Alma K Moreno-Romero, Antoine Baudin, Xiaoping Xu, Jeetain Mittal, David S Libich

Journal: biorxiv

PubMed ID: 37961424

Doi: 10.1101/2023.10.27.564484

Products & Services: Proteins, Expression, Isolation and Analysis

Changes in intestinal flora of mice induced by rEgP29 epitope peptide vaccines

Authors: Tingting Zhang, Yongxue Lv, Yinqi Zhao, Jihui Yang, Bingshuo Qian, Yazhou Zhu, Wei Zhao, Mingxing Zhu

Journal: Immun Inflamm Dis

PubMed ID: 38018604

Doi: 10.1002/iid3.1082

Products & Services: Proteins, Expression, Isolation and Analysis

AR/RKIP pathway mediates the inhibitory effects of icariin on renal fibrosis and endothelial-to-mesenchymal transition in type 2 diabetic nephropathy

Authors: Wenhui Yao, Rongpin Tao, Yue Xu, Zhe-Sheng Chen, Xuansheng Ding, Lisheng Wan

Journal: J Ethnopharmacol

PubMed ID: 37977422

Doi: 10.1016/j.jep.2023.117414

Products & Services: Proteins, Expression, Isolation and Analysis

Application of machine learning algorithms to construct and validate a prediction model for coronary heart disease risk in patients with periodontitis: a population-based study

Authors: Yicheng Wang, Binghang Ni, Yuan Xiao, Yichang Lin, Yu Jiang, Yan Zhang

Journal: Front Cardiovasc Med

PubMed ID: 38094122

Doi: 10.3389/fcvm.2023.1296405

Products & Services: Proteins, Expression, Isolation and Analysis

Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response

Authors: Joel H Graber, Derick Hoskinson, Huiyun Liu, Katarzyna Kaczmarek Michaels, Peter S Benson, Nathaniel J Maki, Christian L Wilson, Caleb McGrath, Franco Puleo, Erika Pearson, Jason N Kuehner, Claire Moore

Journal: Genetics

PubMed ID: 37967370

Doi: 10.1093/genetics/iyad199

Products & Services: Proteins, Expression, Isolation and Analysis

Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

Authors: Nafiseh Sabri, Matthew J Cuneo, Melissa R Marzahn, Jihun Lee, Jill J Bouchard, Ömer Güllülü, Sivaraja Vaithiyalingam, Madeleine B Borgia, Jeremy Schmit, Tanja Mittag

Journal: J Biol Chem

PubMed ID: 37926283

Doi: 10.1016/j.jbc.2023.105427

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 ORF7a blocked autophagy flux by intervening in the fusion between autophagosome and lysosome to promote viral infection and pathogenesis

Authors: Shun Li, Xiaobo Li, Haowei Liang, Kuike Yu, Jingbo Zhai, Mengzhou Xue, Zhuojing Luo, Chunfu Zheng, Hao Zhang

Journal: J Med Virol

PubMed ID: 37916857

Doi: 10.1002/jmv.29200

Products & Services: Proteins, Expression, Isolation and Analysis

RING-type E3 ligase BnaJUL1 ubiquitinates and degrades BnaTBCC1 to regulate drought tolerance in Brassica napus L

Authors: Jin Hu, Mudan Luo, Xianming Zhou, Zhaoyang Wang, Li Yan, Dengfeng Hong, Guangsheng Yang, Xiaohui Zhang

Journal: Plant Cell Environ

PubMed ID: 37984059

Doi: 10.1111/pce.14770

Products & Services: Proteins, Expression, Isolation and Analysis

TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1

Authors: Hansol Heo, Hyungsun Park, Myung Shin Lee, Jongyoon Kim, Juyeong Kim, Soon-Young Jung, Sun Kyeon Kim, Seongju Lee, Jaerak Chang

Journal: Autophagy

PubMed ID: 38009729

Doi: 10.1080/15548627.2023.2287925

Products & Services: Proteins, Expression, Isolation and Analysis

Cancer Relevance of Circulating Antibodies Against LINE-1 Antigens in Humans

Authors: Alexandra V Vylegzhanina, Ivan A Bespalov, Ksenia A Novototskaya-Vlasova, Brandon M Hall, Anatoli S Gleiberman, Han Yu, Olga V Leontieva, Katerina I Leonova, Oleg V Kurnasov, Andrei L Osterman, Grace K Dy, Alexey A Komissarov, Elena Vasilieva, Jeff Gehlhausen, Akiko Iwasaki, Christine B Ambrosone, Takemasa Tsuji, Junko Matsuzaki, Kunle Odunsi, Ekaterina L Andrianova, Andrei V Gudkov

Journal: Cancer Res Commun

PubMed ID: 37870410

Doi: 10.1158/2767-9764.CRC-23-0289

Products & Services: Proteins, Expression, Isolation and Analysis

Increasing insight in the value of repetitive COVID-19 vaccination in patients with haematological malignancies in the Omicron era

Authors: Ulrike Bacher, Evgenii Shumilov, Thomas Pabst

Journal: Br J Haematol

PubMed ID: 37984996

Doi: 10.1111/bjh.19221

Products & Services: Proteins, Expression, Isolation and Analysis

OsALB3 Is Required for Chloroplast Development by Promoting the Accumulation of Light-Harvesting Chlorophyll-Binding Proteins in Rice

Authors: Chao Zhang, Xinchen Mao, Xiaoxiao Feng, Yali Sun, Zirui Wang, Jiaqi Tang, Hengxiu Yu

Journal: Plants (Basel)

PubMed ID: 38068638

Doi: 10.3390/plants12234003

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Structure and functional divergence of PIP peptide family revealed by functional studies on PIP1 and PIP2 in

Authors: Xiao-Song Yu, Hong-Run Wang, Fei-Fan Lei, Rui-Qi Li, Hui-Peng Yao, Jin-Bo Shen, Noor-Ul Ain, Yi Cai

Journal: Front Plant Sci

PubMed ID: 38078092

Doi: 10.3389/fpls.2023.1208549

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Ligand-based targeting of c-kit using engineered γδ T cells as a strategy for treating acute myeloid leukemia

Authors: Gianna M Branella, Jasmine Y Lee, Jennifer Okalova, Kiran K Parwani, Jordan S Alexander, Raquel F Arthuzo, Andrew Fedanov, Bing Yu, David McCarty, Harrison C Brown, Shanmuganathan Chandrakasan, Brian G Petrich, Christopher B Doering, H Trent Spencer

Journal: Front Immunol

PubMed ID: 38022523

Doi: 10.3389/fimmu.2023.1294555

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Substance P Increases STAT6-Mediated Transcription Activation of Lymphocyte Cytosolic Protein 2 to Sustain M2 Macrophage Predominance in Pediatric Asthma

Authors: Miao Li, Xiao Zhong, Wenting Xu

Journal: Am J Pathol

PubMed ID: 37995836

Doi: 10.1016/j.ajpath.2023.11.003

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Juvenile hormone induces reproduction via miR-1175-3p in the red imported fire ant, Solenopsis invicta

Authors: Jie Chen, Ziying Guan, Yunjie Ma, Qingxing Shi, Ting Chen, Muhammad Irfan Waris, Lihua Lyu, Yongyue Lu, Guojun Qi

Journal: Insect Sci

PubMed ID: 37933419

Doi: 10.1111/1744-7917.13291

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Biophysical and biochemical characterization of the thioredoxin system from Colwellia psychrerythraea

Authors: Naheda Sahtout, David A R Sanders

Journal: Proteins

PubMed ID: 37909486

Doi: 10.1002/prot.26627

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Mesenchymal stem cells attenuate systemic lupus erythematosus by inhibiting NLRP3 inflammasome activation through Pim-1 kinase

Authors: Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun

Journal: Int Immunopharmacol

PubMed ID: 37992447

Doi: 10.1016/j.intimp.2023.111256

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Human leukocyte antigen HLA-DR-expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis

Authors: Joseph R Rouse, Rebecca Danner, Amanda Wahhab, Michaela Pereckas, Mecaila E McClune, Allen C Steere, Klemen Strle, Brandon L Jutras, Robert B Lochhead

Journal: biorxiv

PubMed ID: 38045407

Doi: 10.1101/2023.11.21.568066

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NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Authors: Yves Dondelinger, Dario Priem, Jon Huyghe, Tom Delanghe, Peter Vandenabeele, Mathieu J M Bertrand

Journal: Cell Death Dis

PubMed ID: 37980412

Doi: 10.1038/s41419-023-06284-z

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Single-injection subunit vaccine for rabies prevention using lentinan as adjuvant

Authors: Xiaoyong Zhou, Haozheng Wang, Jianchen Zhang, Ying Guan, Yongjun Zhang

Journal: Int J Biol Macromol

PubMed ID: 37977452

Doi: 10.1016/j.ijbiomac.2023.128118

Products & Services: Proteins, Expression, Isolation and Analysis

Telomerase Upregulation Induces Progression of Mouse BrafV600E-Driven Thyroid Cancers and Triggers Nontelomeric Effects

Authors: Iñigo Landa, Caitlin E M Thornton, Bin Xu, Jacob Haase, Gnana P Krishnamoorthy, Jingzhu Hao, Jeffrey A Knauf, Zachary T Herbert, Paula Martínez, María A Blasco, Ronald Ghossein, James A Fagin

Journal: Mol Cancer Res

PubMed ID: 37478162

Doi: 10.1158/1541-7786.MCR-23-0144

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A glutamate-gated chloride channel as the mite-specific target-site of dicofol and other diphenylcarbinol acaricides

Authors: Marilou Vandenhole, Catherine Mermans, Berdien De Beer, Wenxin Xue, Yilan Zhao, Yoshihisa Ozoe, Genyan Liu, Wannes Dermauw, Thomas Van Leeuwen

Journal: Commun Biol

PubMed ID: 37957415

Doi: 10.1038/s42003-023-05488-5

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Conserved antigen structures and antibody-driven variations on foot-and-mouth disease virus serotype A revealed by bovine neutralizing monoclonal antibodies

Authors: Kun Li, Yong He, Li Wang, Pinghua Li, Huifang Bao, Shulun Huang, Shasha Zhou, Guoqiang Zhu, Yali Song, Ying Li, Sheng Wang, Qianliang Zhang, Pu Sun, Xingwen Bai, Zhixun Zhao, Zhiyong Lou, Yimei Cao, Zengjun Lu, Zaixin Liu

Journal: PLoS Pathog

PubMed ID: 37983290

Doi: 10.1371/journal.ppat.1011811

Products & Services: Proteins, Expression, Isolation and Analysis

Sulforaphene suppressed cell proliferation and promoted apoptosis of COV362 cells in endometrioid ovarian cancer

Authors: Hui-Yan Yu, Li Yang, Yuan-Cai Liu, Ai-Jun Yu

Journal: PeerJ

PubMed ID: 38025760

Doi: 10.7717/peerj.16308

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Extracellular and intracellular destruction of Pseudomonas aeruginosa by Dictyostelium discoideum phagocytes mobilize different antibacterial mechanisms

Authors: Imen Ayadi, Otmane Lamrabet, Raphael Munoz-Ruiz, Tania Jauslin, Cyril Guilhen, Pierre Cosson

Journal: Mol Microbiol

PubMed ID: 38017607

Doi: 10.1111/mmi.15197

Products & Services: Proteins, Expression, Isolation and Analysis

Isolation and characterization of the aspartame-degrading strain Pseudarthrobacter sp AS-1

Authors: Zhijian Ke, Junyun Song, Jingrui Ma, Mengting Wang, Haiguang Mao, Chunli Xia, Lili Qi, Yidong Zhou, Jinbo Wang

Journal: Environ Pollut

PubMed ID: 37944888

Doi: 10.1016/j.envpol.2023.122883

Products & Services: Gene Synthesis

Prenatal diagnostic approaches diagnosed craniosynostosis and identified a novel nonsense variant in SMAD6 in a Chinese fetus

Authors: Zhidan Hong, Xuanyi He, Jie Duan, Fang Yu, Huanyu Liu, Dan Lu, Mei Wang, Yuanzhen Zhang

Journal: Gene

PubMed ID: 37977316

Doi: 10.1016/j.gene.2023.147994

Products & Services: Molecular Biology Reagents

A second-generation M1-polarized CAR macrophage with antitumor efficacy

Authors: Anhua Lei, Hua Yu, Shan Lu, Hengxing Lu, Xizhong Ding, Tianyu Tan, Hailing Zhang, Mengmeng Zhu, Lin Tian, Xudong Wang, Siyu Su, Dixuan Xue, Shaolong Zhang, Wei Zhao, Yuge Chen, Wanrun Xie, Li Zhang, Yuqing Zhu, Jing Zhao, Wenhong Jiang, George Church, Francis Ka-Ming Chan, Zhihua Gao, Jin Zhang

Journal: Nat Immunol

PubMed ID: 38012418

Doi: 10.1038/s41590-023-01687-8

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Role and mechanism of miR-871-3p/Megf8 in regulating formaldehyde-induced cardiomyocyte inflammation and congenital heart disease

Authors: Xiaoli Yuan, Rui Chen, Gang Luo, Pin Sun, Xiaoxia Song, Jianmin Ma, Ruicong Sun, Tao Yu, Zhirong Jiang

Journal: Int Immunopharmacol

PubMed ID: 38039718

Doi: 10.1016/j.intimp.2023.111297

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered immunogens to elicit antibodies against conserved coronavirus epitopes

Authors: A Brenda Kapingidza, Daniel J Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schäfer, Amanda Eaton, Justine Mae Flores, Austin Harner, Nicholas J Catanzaro, Michael L Mallory, Melissa D Mattocks, Christopher Beverly, Brianna Rhodes, Katayoun Mansouri, Elizabeth Van Itallie, Pranay Vure, Brooke Dunn, Taylor Keyes, Sherry Stanfield-Oakley, Christopher W Woods, Elizabeth A Petzold, Emmanuel B Walter, Kevin Wiehe, Robert J Edwards, David C Montefiori, Guido Ferrari, Ralph Baric, Derek W Cain, Kevin O Saunders, Barton F Haynes, Mihai L Azoitei

Journal: Nat Commun

PubMed ID: 38036525

Doi: 10.1038/s41467-023-43638-9

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity

Authors: Seounghun Kang, Aslan Mansurov, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Kevin Chang, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Jun Ishihara, Melody A Swartz, Jeffrey A Hubbell

Journal: Sci Adv

PubMed ID: 38019919

Doi: 10.1126/sciadv.adh9879

Products & Services: Proteins, Expression, Isolation and Analysis

Jianpi Huayu Decoction suppresses cellular senescence in colorectal cancer via p53-p21-Rb pathway: Network pharmacology and in vivo validation

Authors: Shiting Wang, Ying Xing, Ruiping Wang, Zhichao Jin

Journal: J Ethnopharmacol

PubMed ID: 37931831

Doi: 10.1016/j.jep.2023.117347

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Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Authors: Max Pearson, Carl Haslam, Andrew Fosberry, Emma J Jones, Mark Reglinski, Lucy Reeves, Robert J Edwards, Richard Ashley Lawrenson, Jonathan C Brown, Danuta Mossakowska, James Edward Pease, Shiranee Sriskandan

Journal: Sci Rep

PubMed ID: 37923786

Doi: 10.1038/s41598-023-46036-9

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Safety and efficacy of the intranasal spray SARS-CoV-2 vaccine dNS1-RBD: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Authors: Fengcai Zhu, Shoujie Huang, Xiaohui Liu, Qi Chen, Chunlan Zhuang, Hui Zhao, Jinle Han, Anjuli May Jaen, Thai Hung Do, Jonathan Grant Peter, Alexander Gonzalez Dorado, Louie S Tirador, Gelza Mae A Zabat, Ralph Elvi M Villalobos, Gemalyn Pineda Gueco, Lauren Livia Greta Botha, Shirley Patricia Iglesias Pertuz, Jiaxiang Tan, Kongxin Zhu, Jiali Quan, Hongyan Lin, Yue Huang, Jizong Jia, Xiafei Chu, Junyu Chen, Yixin Chen, Tianying Zhang, Yingying Su, Changgui Li, Xiangzhong Ye, Ting Wu, Jun Zhang, Ningshao Xia

Journal: Lancet Respir Med

PubMed ID: 37979588

Doi: 10.1016/S2213-2600(23)00349-1

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Experimental co-infection of calves with SARS-CoV-2 Delta and Omicron variants of concern

Authors: Konner Cool, Natasha N Gaudreault, Jessie D Trujillo, Igor Morozov, Chester D McDowell, Dashzeveg Bold, Taeyong Kwon, Velmurugan Balaraman, Patricia Assato, Daniel W Madden, Emily Mantlo, Jayme Souza-Neto, Franco Matias-Ferreyra, Jaime Retallick, Gagandeep Singh, Michael Schotsaert, Mariano Carossino, Udeni B R Balasuriya, William C Wilson, Roman M Pogranichniy, Adolfo García-Sastre, Juergen A Richt

Journal: Emerg Microbes Infect

PubMed ID: 37938158

Doi: 10.1080/22221751.2023.2281356

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RAGE Is a Receptor for SARS-CoV-2 N Protein and Mediates N Protein-induced Acute Lung Injury

Authors: Jie Xia, Jiangmei Wang, Liyang Ying, Ruoqiong Huang, Kai Zhang, Ruoyang Zhang, Wenqi Tang, Qi Xu, Dengming Lai, Yan Zhang, Yaoqin Hu, Xiaodie Zhang, Ruoxi Zang, Jiajie Fan, Qiang Shu, Jianguo Xu

Journal: Am J Respir Cell Mol Biol

PubMed ID: 37478333

Doi: 10.1165/rcmb.2022-0351OC

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ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells

Authors: Meng Bian, Shan Li, Hanzong Zhou, Lijun Bi, Yong Shen, Chen Tingjin, Xinbing Yu, Yan Huang, Qingxia Xu

Journal: PLoS Negl Trop Dis

PubMed ID: 37948465

Doi: 10.1371/journal.pntd.0011727

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