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Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations

Authors: Fiona L Wong, Thomas A Bunch, Victoria C Lepak, Allison L Steedman, Brett A Colson

Journal: J Mol Cell Cardiol

PubMed ID: 38008210

Doi: 10.1016/j.yjmcc.2023.11.010

Products & Services: Molecular Biology Reagents

Genetic manipulation of giant viruses and their host, Acanthamoeba castellanii

Authors: Nadege Philippe, Avi Shukla, Chantal Abergel, Hugo Bisio

Journal: Nat Protoc

PubMed ID: 37964008

Doi: 10.1038/s41596-023-00910-y

Products & Services: Custom DNA/RNA Oligos

Structural and biophysical properties of a [4Fe4S] ferredoxin-like protein from Synechocystis sp PCC 6803 with a unique two domain structure

Authors: Effie Kisgeropoulos, Vivek S Bharadwaj, Anastasia Ledinina, Carolyn E Lubner, David W Mulder, Sharon L Smolinski, Marko Boehm, Kirstin Gutekunst, Paul W King, Drazenka Svedruzic

Journal: J Inorg Biochem

PubMed ID: 38008043

Doi: 10.1016/j.jinorgbio.2023.112428

Products & Services: DNA Sequencing

Sirtuin 3-mediated deacetylation of superoxide dismutase 2 ameliorates sodium fluoride-induced mitochondrial dysfunction in porcine oocytes

Authors: Xin-Yue Qi, Jin-Dong Yuan, Zi-Yu Liu, Xi-Qing Jiang, Qi Zhang, Shan-Long Zhang, Lu Zhao, Ling-Yan Ke, Chen-Yuan Zhang, Yan Li, Lu-Yan Zhang, Qian-Qian Xu, Zhong-Hua Liu, Jing-Tao Sun, Jun-Xue Jin

Journal: Sci Total Environ

PubMed ID: 37944611

Doi: 10.1016/j.scitotenv.2023.168306

Products & Services: Proteins, Expression, Isolation and Analysis

Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite

Authors: Rahul Singh Rawat, Ankit Gupta, Neelam Antil, Sonika Bhatnagar, Monika Singh, Akanksha Rawat, T S Keshava Prasad, Pushkar Sharma

Journal: PLoS Pathog

PubMed ID: 37988347

Doi: 10.1371/journal.ppat.1011770

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting the COMMD4-H2B protein complex in lung cancer

Authors: Ming Tang, Joshua T Burgess, Mark Fisher, Didier Boucher, Emma Bolderson, Neha S Gandhi, Kenneth J O'Byrne, Derek J Richard, Amila Suraweera

Journal: Br J Cancer

PubMed ID: 37914802

Doi: 10.1038/s41416-023-02476-8

Products & Services: Proteins, Expression, Isolation and Analysis

Regioselective Glycosylation of Polyphenols by Family 1 Glycosyltransferases: Experiments and Simulations

Authors: Ruben M de Boer, Dovydas Vaitkus, Kasper Enemark-Rasmussen, Sören Maschmann, David Teze, Ditte H Welner

Journal: ACS Omega

PubMed ID: 38075805

Doi: 10.1021/acsomega.3c08255

Products & Services: Proteins, Expression, Isolation and Analysis

Extracellular electron uptake from a cathode by the lactic acid bacterium

Authors: Sara Tejedor-Sanz, Siliang Li, Biki Bapi Kundu, Caroline M Ajo-Franklin

Journal: Front Microbiol

PubMed ID: 38075918

Doi: 10.3389/fmicb.2023.1298023

Products & Services: Molecular Biology Reagents

Comparative Computational Analysis of Spike Protein Structural Stability in SARS-CoV-2 Omicron Subvariants

Authors: Anand Balupuri, Jeong-Min Kim, Kwang-Eun Choi, Jin Sun No, Il-Hwan Kim, Jee Eun Rhee, Eun-Jin Kim, Nam Sook Kang

Journal: Int J Mol Sci

PubMed ID: 38003257

Doi: 10.3390/ijms242216069

Products & Services: Molecular Biology Reagents

The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells

Authors: Jing Cheng, Yutong Wang, Lizheng Yin, Wenzhang Liang, Jing Zhang, Cuiqing Ma, Yu Zhang, Bo Liu, Jiachao Wang, Weiting Zhao, Miao Li, Lin Wei

Journal: MBio

PubMed ID: 37909764

Doi: 10.1128/mbio.01480-23

Products & Services: Molecular Biology Reagents

IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma

Authors: Junnan Ru, Jiahua Lu, Jiangzhen Ge, Bo Ding, Rong Su, Yifan Jiang, Yujing Sun, Jun Ma, Yu Li, Jingqi Sun, Guangming Xu, Rongliang Tong, Shusen Zheng, Beng Yang, Jian Wu

Journal: Cancer Lett

PubMed ID: 37993085

Doi: 10.1016/j.canlet.2023.216495

Products & Services: Recombinant Antibody Expression

Mechanism of actin capping protein recruitment and turnover during clathrin-mediated endocytosis

Authors: Andrew K Lamb, Andres N Fernandez, Abdunaser Eadaim, Katelyn Johnson, Santiago M Di Pietro

Journal: J Cell Biol

PubMed ID: 37966720

Doi: 10.1083/jcb.202306154

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Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

Authors: Haofeng Wang, Qi Yang, Xiaoce Liu, Zili Xu, Maolin Shao, Dongxu Li, Yinkai Duan, Jielin Tang, Xianqiang Yu, Yumin Zhang, Aihua Hao, Yajie Wang, Jie Chen, Chenghao Zhu, Luke Guddat, Hongli Chen, Leike Zhang, Xinwen Chen, Biao Jiang, Lei Sun, Zihe Rao, Haitao Yang

Journal: Nat Commun

PubMed ID: 37990007

Doi: 10.1038/s41467-023-42527-5

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Retraction: Epitopes screening and vaccine molecular design of SADS-CoV based on immunoinformatics

Authors:

Journal: Front Vet Sci

PubMed ID: 38105774

Doi: 10.3389/fvets.2023.1342203

Products & Services: Gene Synthesis

Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models

Authors: Viviane M Andrade, Igor Maricic, Richa Kalia, Lauren Jachimowicz, Olivia Bedoya, Daniel W Kulp, Laurent Humeau, Trevor R F Smith

Journal: Hum Vaccin Immunother

PubMed ID: 38012018

Doi: 10.1080/21645515.2023.2281733

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Antagonistic conflict between transposon-encoded introns and guide RNAs

Authors: Rimantė Žedaveinytė, Chance Meers, Hoang C Le, Edan E Mortman, Stephen Tang, George D Lampe, Sanjana R Pesari, Diego R Gelsinger, Tanner Wiegand, Samuel H Sternberg

Journal: biorxiv

PubMed ID: 38045383

Doi: 10.1101/2023.11.20.567912

Products & Services: Molecular Biology Reagents

A Versatile Platform to Generate Prodrugs with Rapid and Precise Albumin Hitchhiking and High Cargo Loading for Tumor-Targeted Chemotherapy

Authors: Jing Li, Huimin Xing, Jie Chen, Hongyu Lu, Ze Tao, Yiran Tao, Yunqing Sun, Tao Su, Xin Li, Huansheng Chang, Shiyuan Chen, Zhuo Chen, Hao Yang, Jingqiu Cheng, Hong Zhu, Xiaofeng Lu

Journal: Small

PubMed ID: 37963821

Doi: 10.1002/smll.202304253

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Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19

Authors: Maya F Amjadi, Maxwell H Parker, Ryan R Adyniec, Zihao Zheng, Alex M Robbins, S Janna Bashar, Michael F Denny, Sara S McCoy, Irene M Ong, Miriam A Shelef

Journal: J Autoimmun

PubMed ID: 37956528

Doi: 10.1016/j.jaut.2023.103132

Products & Services: Proteins, Expression, Isolation and Analysis

Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy

Authors: Daoyuan Xie , Yaomei Tian , Die Hu , Yuanda Wang , Yuling Yang , Bailing Zhou , Rui Zhang , Zhixiang Ren , Mohan Liu , Jie Xu , Chunyan Dong , Binyan Zhao , Li Yang

Journal: Signal Transduct Target Ther .

PubMed ID: 38016957

Doi: 10.1038/s41392-023-01683-2

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insights into asymmetric activation of the calciumsensing receptor–Gq complex

Authors: Shenglong Ling, Xianyu Meng, Yuan Zhang, Zhemin Xia, Yingxin Zhou, Fan Yang, Pan Shi, Chaowei Shi, Changlin Tian

Journal: Cell Res .

PubMed ID: 37919470

Doi: 10.1038/s41422-023-00892-2

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Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations

Authors: Brittany N Williams, Adam Draper, Patrick F Lang, Tylor R Lewis, Audrey L Smith, Steven J Mayerl, Marie Rougié, Jeremy M Simon, Vadim Y Arshavsky, Scott H Greenwald, David M Gamm, Isabel Pinilla, Benjamin D Philpot

Journal: Hum Mol Genet

PubMed ID: 37975905

Doi: 10.1093/hmg/ddad199

Products & Services: Proteins, Expression, Isolation and Analysis

IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjögren's syndrome

Authors: Xiaoyu Xia, Qiqiang Long, Jie Zha, Tingting Jiang, Junqiao Guo, Bo Jiang, Xiaojing Li, Genhong Yao

Journal: Int Immunol

PubMed ID: 37756640

Doi: 10.1093/intimm/dxad037

Products & Services: Molecular Biology Reagents

Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease

Authors: Yael Gruper, Anette S B Wolff, Liad Glanz, Frantisek Spoutil, Mihaela Cuida Marthinussen, Adriana Osickova, Yonatan Herzig, Yael Goldfarb, Goretti Aranaz-Novaliches, Jan Dobeš, Noam Kadouri, Osher Ben-Nun, Amit Binyamin, Bar Lavi, Tal Givony, Razi Khalaila, Tom Gome, Tomáš Wald, Blanka Mrazkova, Carmel Sochen, Marine Besnard, Shifra Ben-Dor, Ester Feldmesser, Elisaveta M Orlova, Csaba Hegedűs, István Lampé, Tamás Papp, Szabolcs Felszeghy, Radislav Sedlacek, Esti Davidovich, Noa Tal, Dror S Shouval, Raanan Shamir, Carole Guillonneau, Zsuzsa Szondy, Knut E A Lundin, Radim Osicka, Jan Prochazka, Eystein S Husebye, Jakub Abramson

Journal: Nature

PubMed ID: 37993717

Doi: 10.1038/s41586-023-06776-0

Products & Services: Proteins, Expression, Isolation and Analysis

Mechanism of δ Mediated Transcription Activation in Bacillus subtilis: Interaction with α CTD of RNA Polymerase Stabilizes δ and Successively Facilitates the Open Complex Formation

Authors: Aniruddha Tewary, Ranjit Kumar Prajapati, Jayanta Mukhopadhyay

Journal: J Mol Biol

PubMed ID: 37972688

Doi: 10.1016/j.jmb.2023.168366

Products & Services: Proteins, Expression, Isolation and Analysis

RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms

Authors: Sudarsan Mugunthan, Lan Li Wong, Fernaldo Richtia Winnerdy, Stephen Summers, Muhammad Hafiz Bin Ismail, Yong Hwee Foo, Tavleen Kaur Jaggi, Oliver W Meldrum, Pei Yee Tiew, Sanjay H Chotirmall, Scott A Rice, Anh Tuân Phan, Staffan Kjelleberg, Thomas Seviour

Journal: Nat Commun

PubMed ID: 38012164

Doi: 10.1038/s41467-023-43533-3

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Effects of protoscoleces excretory-secretory products of Echinococcus granulosus on hepatocyte growth, function, and glucose metabolism

Authors: Guangyi Luo, Haiwen Li, Qiong Lu, Jiangtao Cao, Hailong Lv, Yufeng Jiang

Journal: Acta Trop

PubMed ID: 37944837

Doi: 10.1016/j.actatropica.2023.107066

Products & Services: Molecular Biology Reagents

Ana Castillo Discusses Sexuality, Identity, and Life-Then and Now

Authors: Liliana C Gonzalez, Stacy I Macias

Journal: J Lesbian Stud

PubMed ID: 37791458

Doi: 10.1080/10894160.2023.2250670

Products & Services: Plasmid DNA Preparation

Diurnal regulation of alternative splicing associated with thermotolerance in rice by two glycine-rich RNA-binding proteins

Authors: Chuang Yang, Anni Luo, Hai-Ping Lu, Seth Jon Davis, Jian-Xiang Liu

Journal: Sci Bull (Beijing)

PubMed ID: 38044192

Doi: 10.1016/j.scib.2023.11.046

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2

Authors: Shengnan Zhu, Qingning Yuan, Xinzhu Li, Xinheng He, Shiyi Shen, Dongxue Wang, Junrui Li, Xi Cheng, Xiaoqun Duan, H Eric Xu, Jia Duan

Journal: Cell Rep

PubMed ID: 37952153

Doi: 10.1016/j.celrep.2023.113406

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Non-canonical MLL1 activity regulates centromeric phase separation and genome stability

Authors: Liang Sha, Zi Yang, Sojin An, Wentao Yang, Sungmin Kim, Hoon Oh, Jing Xu, Jun Yin, He Wang, Heinz-Josef Lenz, Woojin An, Uhn-Soo Cho, Yali Dou

Journal: Nat Cell Biol

PubMed ID: 37945831

Doi: 10.1038/s41556-023-01270-1

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ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer

Authors: Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma

Journal: Cell Signal

PubMed ID: 38000525

Doi: 10.1016/j.cellsig.2023.110979

Products & Services: Molecular Biology Reagents

Reconstruction of dynamic mammary mini gland in vitro for normal physiology and oncogenesis

Authors: Lei Yuan, Shaofang Xie, Huiru Bai, Xiaoqin Liu, Pei Cai, Jing Lu, Chunhui Wang, Zuobao Lin, Shuying Li, Yajing Guo, Shang Cai

Journal: Nat Methods

PubMed ID: 37919421

Doi: 10.1038/s41592-023-02039-y

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Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding

Authors: Zhi Li , Ning Wu , Jing Wang , Yang Yue , Lihua Geng , Quanbin Zhang

Journal: Br J Pharmacol .

PubMed ID: 37994102

Doi: 10.1111/bph.16288

Products & Services: Proteins, Expression, Isolation and Analysis

Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance

Authors: Yanping Yang, Raymond Louie, Janusz Puc, Yogindra Vedvyas, Yago Alcaina, Irene M Min, Matt Britz, Fabio Luciani, Moonsoo M Jin

Journal: Cancers (Basel)

PubMed ID: 38067255

Doi: 10.3390/cancers15235552

Products & Services: Proteins, Expression, Isolation and Analysis

Regulation of Atg8 membrane deconjugation by cysteine proteases in the malaria parasite Plasmodium berghei

Authors: Akancha Mishra, Aastha Varshney, Satish Mishra

Journal: Cell Mol Life Sci

PubMed ID: 37910326

Doi: 10.1007/s00018-023-05004-2

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Enhancing the Physicochemical Attributes of Dough and Noodles through the Incorporation of Laccase

Authors: Xiaoyu Zhu, Shijin Zhang, Luyao Bian, Juan Shen, Chong Zhang, Sivakumar Manickam, Yang Tao, Zhaoxin Lu

Journal: Foods

PubMed ID: 38002203

Doi: 10.3390/foods12224146

Products & Services: Proteins, Expression, Isolation and Analysis

Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51

Authors: Lei Tao, Yue Zhou, Xiangyu Pan, Yuan Luo, Jiahao Qiu, Xia Zhou, Zhiqian Chen, Yan Li, Lian Xu, Yang Zhou, Zeping Zuo, Chunqi Liu, Liang Wang, Xiaocong Liu, Xinyu Tian, Na Su, Zhengnan Yang, Yu Zhang, Kun Gou, Na Sang, Huan Liu, Jiao Zou, Yuzhou Xiao, Xi Zhong, Jing Xu, Xinyu Yang, Kai Xiao, Yanyang Liu, Shengyong Yang, Yong Peng, Junhong Han, Xiaobo Cen, Yinglan Zhao

Journal: Nat Commun

PubMed ID: 37973845

Doi: 10.1038/s41467-023-42850-x

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Author Correction: A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques

Authors: Ting Bian, Meng Hao, Xiaofan Zhao, Chuanyi Zhao, Gang Luo, Zhendong Zhang, Guangcheng Fu, Lu Yang, Yi Chen, Yudong Wang, Changming Yu, Yilong Yang, Jianmin Li, Wei Chen

Journal: npj Vaccines

PubMed ID: 38017028

Doi: 10.1038/s41541-023-00780-1

Products & Services: Proteins, Expression, Isolation and Analysis

Inflammation primes the kidney for recovery by activating AZIN1 A-to-I editing

Authors: Segewkal Heruye, Jered Myslinski, Chao Zeng, Amy Zollman, Shinichi Makino, Azuma Nanamatsu, Quoseena Mir, Sarath Chandra Janga, Emma H Doud, Michael T Eadon, Bernhard Maier, Michiaki Hamada, Tuan M Tran, Pierre C Dagher, Takashi Hato

Journal: biorxiv

PubMed ID: 37986799

Doi: 10.1101/2023.11.09.566426

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Dual function of Zika virus NS2B-NS3 protease

Authors: Sergey A Shiryaev, Piotr Cieplak, Anton Cheltsov, Robert C Liddington, Alexey V Terskikh

Journal: PLoS Pathog

PubMed ID: 38011215

Doi: 10.1371/journal.ppat.1011795

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Engineering the synthetic β-alanine pathway in Komagataella phaffii for conversion of methanol into 3-hydroxypropionic acid

Authors: Sílvia Àvila-Cabré, Míriam Pérez-Trujillo, Joan Albiol, Pau Ferrer

Journal: Microb Cell Fact

PubMed ID: 37978380

Doi: 10.1186/s12934-023-02241-9

Products & Services: Proteins, Expression, Isolation and Analysis

Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight

Authors: Min-Zhi Chen, Ping Xie, Xiao-Chang Wu, Zhen-Hua Tan, Hai Qian, Zhi-Hong Ma, Xing Yao

Journal: Hepatobiliary Pancreat Dis Int

PubMed ID: 38040523

Doi: 10.1016/j.hbpd.2023.11.007

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A Subunit Vaccine Candidate Composed of Mpox Virus A29L, M1R, A35R, and B6R Elicits Robust Immune Response in Mice

Authors: Xuetao Yang , Xidan Yang , Shouwen Du , Congxia Hu , Xiu Yang , Xingyun Wang , Xing Hu , Nino Rcheulishvili , Peng George Wang and Jihui Lin

Journal: Vaccines.

Doi: 10.3390/vaccines11091420

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Fluorescence-quenching lateral flow immunoassay for “turn-on” and sensitive detection of anti-SARS-CoV-2 neutralizing antibodies in human serum

Authors: Lun Bian , Qiangqiang Fu , Zhuoheng Gan , Ze Wu , Yuchen Song , Yufeng Xiong , Fang Hu, Lei Zheng

Journal: Adv Sci (Weinh) .

PubMed ID: 38032112

Doi: 10.1002/advs.202305774

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Functional Characterization of Novel Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

Authors: Idris Mohammed, Senthil Selvaraj, Wesam S Ahmed, Tara Al-Barazenji, Ayat S Hammad, Hajar Dauleh, Luis R Saraiva, Mashael Al-Shafai, Khalid Hussain

Journal: Int J Mol Sci

PubMed ID: 38003551

Doi: 10.3390/ijms242216361

Products & Services: Proteins, Expression, Isolation and Analysis

Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors

Authors: Mikhail Rudinskiy, Maria Pons-Vizcarra, Tatiana Soldà, Ilaria Fregno, Timothy Jan Bergmann, Ana Ruano, Aida Delgado, Sara Morales, Xavier Barril, Manolo Bellotto, Elena Cubero, Ana María García-Collazo, Natalia Pérez-Carmona, Maurizio Molinari

Journal: PLoS ONE

PubMed ID: 38019733

Doi: 10.1371/journal.pone.0294437

Products & Services: Proteins, Expression, Isolation and Analysis

Galectin-14 promotes hepatocellular carcinoma tumor growth enhancing heparan sulfate proteoglycan modification

Authors: Liming Gou, Gang Yang, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Jin Huang, Wei Gao

Journal: J Biomed Res

PubMed ID: 37977559

Doi: 10.7555/JBR.37.20230085

Products & Services: Proteins, Expression, Isolation and Analysis

EBF2 Links KMT2D-Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN

Authors: Bing Yao, Mengying Xing, Shixin Meng, Shang Li, Jingwan Zhou, Ming Zhang, Chen Yang, Shuang Qu, Yucui Jin, Hongyan Yuan, Ke Zen, Changyan Ma

Journal: Adv Sci (Weinh)

PubMed ID: 38015024

Doi: 10.1002/advs.202302037

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A nanoparticle vaccine displaying the ookinete PSOP25 antigen elicits transmission-blocking antibody response against Plasmodium berghei

Authors: Guixiang Yao, Hui Min, Xinxin Yu, Fei Liu, Liwang Cui, Yaming Cao

Journal: Parasit Vectors

PubMed ID: 37932796

Doi: 10.1186/s13071-023-06020-8

Products & Services: Proteins, Expression, Isolation and Analysis

Suburban Population of Bobcats (Lynx rufus) in Connecticut, USA, Tested Negative for SARS-CoV-2, November 2021-February 2022

Authors: Maureen Sims, Zeinab Helal, Milton Levin, Tracy Rittenhouse, Jason Hawley, Guillermo R Risatti

Journal: J Wildl Dis

PubMed ID: 37924242

Doi: 10.7589/JWD-D-23-00054

Products & Services: Proteins, Expression, Isolation and Analysis

Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron

Authors: Daniela Bottero, Erika Rudi, Pablo Martin Aispuro, Eugenia Zurita, Emilia Gaillard, Maria M Gonzalez Lopez Ledesma, Juan Malito, Matthew Stuible, Nicolas Ambrosis, Yves Durocher, Andrea V Gamarnik, Andrés Wigdorovitz, Daniela Hozbor

Journal: Front Immunol

PubMed ID: 38022542

Doi: 10.3389/fimmu.2023.1271209

Products & Services: Proteins, Expression, Isolation and Analysis

Dynamics of Serum-Neutralizing Antibody Responses in Vaccinees through Multiple Doses of the BNT162b2 Vaccine

Authors: Jared Sheehan, Caleb M Ardizzone, Mayank Khanna, Amber J Trauth, Michael E Hagensee, Alistair J Ramsay

Journal: Vaccines (Basel)

PubMed ID: 38006052

Doi: 10.3390/vaccines11111720

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Cytoplasmic production of Fabs in chemically defined media in fed-batch fermentation

Authors: Angel Castillo-Corujo, Mirva J Saaranen, Lloyd W Ruddock

Journal: Protein Expr Purif

PubMed ID: 37979630

Doi: 10.1016/j.pep.2023.106404

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular Analysis of a Congenital Myasthenic Syndrome Due to a Pathogenic Variant Affecting the C-Terminus of ColQ

Authors: Susie Barbeau, Fannie Semprez, Alexandre Dobbertin, Laurine Merriadec, Florine Roussange, Bruno Eymard, Damien Sternberg, Emmanuel Fournier, Hanice Karasoy, Cécile Martinat, Claire Legay

Journal: Int J Mol Sci

PubMed ID: 38003406

Doi: 10.3390/ijms242216217

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Interplay between stochastic enzyme activity and microtubule stability drives detyrosination enrichment on microtubule subsets

Authors: Qing Tang, Sebastian Sensale, Charles Bond, Jiazheng Xing, Andy Qiao, Siewert Hugelier, Arian Arab, Gaurav Arya, Melike Lakadamyali

Journal: Curr Biol

PubMed ID: 37979580

Doi: 10.1016/j.cub.2023.10.068

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DNA Condensation by Peptide-Conjugated PAMAM Dendrimers Influence of Peptide Charge

Authors: Corinna Dannert, Ingrid Mardal, Rahmi Lale, Bjørn Torger Stokke, Rita S Dias

Journal: ACS Omega

PubMed ID: 38046290

Doi: 10.1021/acsomega.3c05140

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The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription

Authors: Jordan Jennings, Harrison Bracey, Danny T Nguyen, Rishav Dasgupta, Alondra Vázquez Rivera, Nicolas Sluis-Cremer, Jiong Shi, Christopher Aiken

Journal: biorxiv

PubMed ID: 37986899

Doi: 10.1101/2023.11.08.566350

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Protein-Phenol Adducts in Meat Proteins: A Molecular Probe Technology Study

Authors: Fenhong Yang, Yingying Zhu, Xiaohan Li, Fengtao Xiang, Moru Deng, Wei Zhang, Wei Song, Hao Sun, Changbo Tang

Journal: Foods

PubMed ID: 38231694

Doi: 10.3390/foods12234225

Products & Services: Proteins, Expression, Isolation and Analysis

Laminin β4 is a constituent of the cutaneous basement membrane zone and additional autoantigen of anti-p200 pemphigoid

Authors: Stephanie Goletz, Manuela Pigors, Tina Rastegar Lari, Christoph M Hammers, Yao Wang, Shirin Emtenani, Monique Aumailley, Maike M Holtsche, Felix H Stang, Imke Weyers, Inke R König, Cristina Has, Christiane Radzimski, Lars Komorowski, Detlef Zillikens, Enno Schmidt

Journal: J Am Acad Dermatol

PubMed ID: 37992812

Doi: 10.1016/j.jaad.2023.11.014

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of mouse CD4 T cell epitopes in SARS-CoV-2 BA1 spike and nucleocapsid for use in peptide:MHCII tetramers

Authors: Laura Bricio Moreno, Juliana Barreto de Albuquerque, Jake M Neary, Thao Nguyen, Kathryn M Hastie, Sara Landeras-Bueno, Chitra Hariharan, Anusha Nathan, Matthew A Getz, Alton C Gayton, Ashok Khatri, Gaurav D Gaiha, Erica Ollmann Saphire, Andrew D Luster, James J Moon

Journal: biorxiv

PubMed ID: 38014059

Doi: 10.1101/2023.11.16.566918

Products & Services: Proteins, Expression, Isolation and Analysis

Chemical protein synthesis enabled engineering of saccharide oxidative cleavage activity in artificial metalloenzymes

Authors: Jindi Luo, Chunmao He

Journal: Int J Biol Macromol

PubMed ID: 38000595

Doi: 10.1016/j.ijbiomac.2023.128083

Products & Services: Proteins, Expression, Isolation and Analysis

Cold atmospheric plasma can effectively disinfect SARS-CoV-2 in the wastewater

Authors: Hongbo Qin, Hengju Qiu, Ke Liu, Bixia Hong, Yuchen Liu, Chun Li, Mengzhe Li, Xiaoping An, Lihua Song, Eric Robert, Yigang Tong, Huahao Fan, Ruixue Wang

Journal: Exploration (Beijing)

PubMed ID: 38939868

Doi: 10.1002/EXP.20230012

Products & Services: Proteins, Expression, Isolation and Analysis

Human mesenchymal stem cells derived from adipose tissue showed a more robust effect than those from the umbilical cord in promoting corneal graft survival by suppressing lymphangiogenesis

Authors: Huanmin Kang, Jianing Feng, Yingqian Peng, Yingyi Liu, Yalei Yang, Ying Wu, Jian Huang, Ying Jie, Baihua Chen, Yan He

Journal: Stem Cell Res Ther

PubMed ID: 37957770

Doi: 10.1186/s13287-023-03559-2

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An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

Authors: Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V Rogov, Ramachandra M Bhaskara, Stefan Müller

Journal: Cell Rep

PubMed ID: 37999976

Doi: 10.1016/j.celrep.2023.113484

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Dual-systems models of the genetic architecture of impulsive personality traits: neurogenetic evidence of distinct but related factors

Authors: Alex P Miller, Ian R Gizer

Journal: Psychol Med

PubMed ID: 38016992

Doi: 10.1017/S0033291723003367

Products & Services: Proteins, Expression, Isolation and Analysis

Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway

Authors: Karim H Saba, Valeria Difilippo, Michal Kovac, Louise Cornmark, Linda Magnusson, Jenny Nilsson, Hilda van den Bos, Diana Cj Spierings, Mahtab Bidgoli, Tord Jonson, Vaiyapuri P Sumathi, Otte Brosjö, Johan Staaf, Floris Foijer, Emelie Styring, Michaela Nathrath, Daniel Baumhoer, Karolin H Nord

Journal: J Pathol

PubMed ID: 38010733

Doi: 10.1002/path.6219

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Varying the RGD concentration on a hyaluronic acid hydrogel influences dormancy versus proliferation in brain metastatic breast cancer cells

Authors: Kasra Goodarzi, Rachel Lane, Shreyas S Rao

Journal: J Biomed Mater Res A

PubMed ID: 38018303

Doi: 10.1002/jbm.a.37651

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Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine

Authors: Yang Zang , Shaorui Liu , Zebing Rao , Yinsheng Wang , Boya Zhang , Hui Li , Yingjiao Cao , Jie Zhou , Zhuxia Shen , Shengzhong Duan , Danyang He , Heping Xu

Journal: Immunity .

PubMed ID: 37714152

Doi: 10.1016/j.immuni.2023.08.019

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Forming a chromium-based interstrand DNA crosslink: Implications for carcinogenicity

Authors: Silas Brown , Sydney Marchi , C Sumner Thomas , Ashlyn R Hale , Molly Lockart , Michael K Bowman , George Christou , Stephen A Woski , John B Vincent

Journal: J Inorg Biochem .

PubMed ID: 38039560

Doi: 10.1016/j.jinorgbio.2023.112439

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Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity

Authors: Le Zheng, Tingting Yang , Hangtian Guo , Chen Qi , Yuchi Lu , Haonan Xiao , Yan Gao , Yue Liu, Yixuan Yang , Mengru Zhou , Henry C Nguyen 1, Yun Zhu 8, Fei Sun 9 10, Chen-Yu Zhang , Xiaoyun Ji

Journal: Cell Research

PubMed ID: 37932445

Doi: s41422-023-00893-1

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Characterization of an L-Arabinose Isomerase from Bacillus velezensis and Its Application for L-Ribulose and L-Ribose Biosynthesis

Authors: Zongren Guo, Liangkun Long, Shaojun Ding

Journal: Appl Biochem Biotechnol

PubMed ID: 32617845

Doi: 10.1007/s12010-020-03380-0

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O-Linked N-Acetylglucosamine Transferase Regulates Bone Homeostasis Through Alkaline Phosphatase Pathway in Diabetic Periodontitis

Authors: Wei Luo, Lu Sun

Journal: Mol Biotechnol

PubMed ID: 37951846

Doi: 10.1007/s12033-023-00947-0

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Transcriptomic analyses reveal proinflammatory activation of human brain microvascular endothelial cells by aging-associated peptide medin and reversal by nanoliposomes

Authors: Yining Zhang, Nina Karamanova, Kaleb T Morrow, Jillian Madine, Seth Truran, Maria Lozoya, Volkmar Weissig, Ming Li, Mehdi Nikkhah, Jin G Park, Raymond Q Migrino

Journal: Sci Rep

PubMed ID: 37914766

Doi: 10.1038/s41598-023-45959-7

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A novel stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

Authors: Jennifer M Podgorski, Joshua Podgorski, Lawrence Abad, Deborah Jacobs-Sera, Krista G Freeman, Colin Brown, Graham Hatfull, Antoni Luque, Simon J White

Journal: biorxiv

PubMed ID: 37961133

Doi: 10.1101/2023.11.03.565530

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Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria

Authors: Daniel J Browne, Ashton M Kelly, Jamie Brady, Carla Proietti, Yomani D Sarathkumara, David J Pattinson, Denise L Doolan

Journal: Sci Rep

PubMed ID: 38030676

Doi: 10.1038/s41598-023-48066-9

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Enhanced C-To-T and A-To-G Base Editing in Mitochondrial DNA with Engineered DdCBE and TALED

Authors: Yinghui Wei, Ming Jin, Shuhong Huang, Fangyao Yao, Ningxin Ren, Kun Xu, Shangpu Li, Pengfei Gao, Yingsi Zhou, Yulin Chen, Hui Yang, Wen Li, Chunlong Xu, Meiling Zhang, Xiaolong Wang

Journal: Adv Sci (Weinh)

PubMed ID: 37984866

Doi: 10.1002/advs.202304113

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Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis

Authors: Hana Lastuvkova, Zuzana Nova, Milos Hroch, Fatemeh Alaei Faradonbeh, Jolana Schreiberova, Jaroslav Mokry, Hana Faistova, Alzbeta Stefela, Jan Dusek, Otto Kucera, Radomír Hyspler, Ester Dohnalkova, Rachel L Bayer, Petra Hirsova, Petr Pavek, Stanislav Micuda

Journal: Toxicol Sci

PubMed ID: 37632784

Doi: 10.1093/toxsci/kfad088

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Self−Assembling Nanovaccine Fused with Flagellin Enhances Protective Effect against Foot−and−Mouth Disease Virus

Authors: Chenchen Pei , Hu Dong , Zhidong Teng , Sumin Wei , Yun Zhang , Shuanghui Yin , Jianli Tang , Shiqi Sun and Huichen Guo

Journal: Vaccines

Doi: 10.3390/vaccines11111675

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Multiple highly expressed phosphoenolpyruvate carboxylase genes have divergent enzyme kinetic properties in two C4 grasses

Authors: Robert J DiMario, Ashley N Kophs, Anthony J A Apalla, James N Schnable, Asaph B Cousins

Journal: Ann Bot

PubMed ID: 37675505

Doi: 10.1093/aob/mcad116

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SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer

Authors: Xiayao Diao, Chao Guo, Hanhao Zheng, Ke Zhao, Yuming Luo, Mingjie An, Yan Lin, Jiancheng Chen, Yuanlong Li, Yuting Li, Xuehan Gao, Jiaqi Zhang, Mengxin Zhou, Wenliang Bai, Lei Liu, Guige Wang, Lanjun Zhang, Xiaotian He, Rusi Zhang, Zhihua Li, Changhao Chen, Shanqing Li

Journal: Signal Transduct Target Ther

PubMed ID: 37925421

Doi: 10.1038/s41392-023-01685-0

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A Novel mechanism of herbicide action through disruption of pyrimidine biosynthesis

Authors: Il-Ho Kang, Ryan P Emptage, Sang-Ic Kim, Steven Gutteridge

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37988466

Doi: 10.1073/pnas.2313197120

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Depletion of L-Methionine in Foods with an Engineered Thermophilic Methionine γ-lyase Efficiently Inhibits Tumor Growth

Authors: Yangming Hu, Yan Liu, Jiulin Zhang, Zhijing Zhou, Jiaxue Wang, Hongyang Chen, Meina Huang, Han Hu, Zongjie Dai, Kaizhi Jia

Journal: J Agric Food Chem

PubMed ID: 37909421

Doi: 10.1021/acs.jafc.3c05293

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Functional and Extracellular Production and Antitumor Activity of Mouse Alpha Klotho in Model Microalga Chlamydomonas reinhardtii

Authors: Ramazan Çakmak, Ugur Uzuner

Journal: Chem Biodivers

PubMed ID: 37997005

Doi: 10.1002/cbdv.202301255

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Development of a Multispecies Double-Antigen Sandwich ELISA Using N and RBD Proteins to Detect Antibodies against SARS-CoV-2

Authors: Maritza Cordero-Ortiz, Mónica Reséndiz-Sandoval, Freddy Dehesa-Canseco, Mario Solís-Hernández, Jahir Pérez-Sánchez, Carlos Martínez-Borges, Verónica Mata-Haro, Jesús Hernández

Journal: Animals (Basel)

PubMed ID: 38003105

Doi: 10.3390/ani13223487

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The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme

Authors: Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic, Elvis Amurrio, Steven D Burbano, Prosun Das, Helen Do, Janet L Fisher, Porschderek Kargbo, Janvi Patel, Latarsha Porcher, Chris I De Zeeuw, Magda A Meester-Smoor, Beerend H J Winkelman, Caroline C W Klaver, Ana Pocivavsek, Michy P Kelly

Journal: biorxiv

PubMed ID: 38014312

Doi: 10.1101/2023.11.16.567422

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Identification of NAD-RNA species and ADPR-RNA decapping in Archaea

Authors: José Vicente Gomes-Filho, Ruth Breuer, Hector Gabriel Morales-Filloy, Nadiia Pozhydaieva, Andreas Borst, Nicole Paczia, Jörg Soppa, Katharina Höfer, Andres Jäschke, Lennart Randau

Journal: Nat Commun

PubMed ID: 37989750

Doi: 10.1038/s41467-023-43377-x

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Enzymatic β-elimination in natural product O- and C-glycoside deglycosylation

Authors: Johannes Bitter, Martin Pfeiffer, Annika J E Borg, Kirill Kuhlmann, Tea Pavkov-Keller, Pedro A Sánchez-Murcia, Bernd Nidetzky

Journal: Nat Commun

PubMed ID: 37932298

Doi: 10.1038/s41467-023-42750-0

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M mazei glutamine synthetase and glutamine synthetase-GlnK1 structures reveal enzyme regulation by oligomer modulation

Authors: Maria A Schumacher, Raul Salinas, Brady A Travis, Rajiv Ranjan Singh, Nicholas Lent

Journal: Nat Commun

PubMed ID: 37968329

Doi: 10.1038/s41467-023-43243-w

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Using for high-yield production of challenging expression targets and for protein deuteration

Authors: Natalia Mojica, Flore Kersten, Mateu Montserrat-Canals, G Robb Huhn, Abelone M Tislevoll, Gabriele Cordara, Ken Teter, Ute Krengel

Journal: biorxiv

PubMed ID: 37961550

Doi: 10.1101/2023.11.03.565449

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Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Authors: Mark Yarmarkovich, Quinlen F Marshall, John M Warrington, Rasika Premaratne, Alvin Farrel, David Groff, Wei Li, Moreno di Marco, Erin Runbeck, Hau Truong, Jugmohit S Toor, Sarvind Tripathi, Son Nguyen, Helena Shen, Tiffany Noel, Nicole L Church, Amber Weiner, Nathan Kendsersky, Dan Martinez, Rebecca Weisberg, Molly Christie, Laurence Eisenlohr, Kristopher R Bosse, Dimiter S Dimitrov, Stefan Stevanovic, Nikolaos G Sgourakis, Ben R Kiefel, John M Maris

Journal: Nature

PubMed ID: 37938785

Doi: 10.1038/s41586-023-06731-z

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Enzymatic degradation of poly(ethylene terephthalate) (PET): Identifying the cause of the hypersensitive enzyme kinetic response to increased PET crystallinity

Authors: Thore Bach Thomsen, Tobias S Radmer, Anne S Meyer

Journal: Enzyme Microb Technol

PubMed ID: 37979402

Doi: 10.1016/j.enzmictec.2023.110353

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Enhancement of adeno-associated virus serotype 6 transduction into T cells with cell-penetrating peptides

Authors: Pablo D Moço, Shantoshini Dash, Amine A Kamen

Journal: J Gene Med

PubMed ID: 37957034

Doi: 10.1002/jgm.3627

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Elevating plant immunity by translational regulation of a rice WRKY transcription factor

Authors: Chao Zheng , Jie Zhou , Xiaoya Yuan , Ersong Zheng , Xiuli Liu , Weijun Cui , Chengqi Yan , Yueyan Wu , Wenyuan Ruan , Keke Yi , Jianping Chen , Xuming Wang

Journal: Plant Biotechnol J .

PubMed ID: 37997501

Doi: 10.1111/pbi.14243

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The yeast prion protein Sup35 initiates α-synuclein pathology in mouse models of Parkinson's disease

Authors: Lanxia Meng, Congcong Liu, Yiming Li, Guiqin Chen, Min Xiong, Ting Yu, Lina Pan, Xingyu Zhang, Lingyan Zhou, Tao Guo, Xin Yuan, Chaoyang Liu, Zhaohui Zhang, Zhentao Zhang

Journal: Sci Adv

PubMed ID: 37910610

Doi: 10.1126/sciadv.adj1092

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Bovine papular stomatitis virus as a vaccine vector for cattle

Authors: Gustavo Delhon, Sushil Khatiwada, David Doub, Seth Harris, Sabal Chaulagain, Mostafa El-Gaffary, Daniel L Rock

Journal: J Gen Virol

PubMed ID: 37976092

Doi: 10.1099/jgv.0.001914

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Identification of CryAB as a target of NUAK kinase activity in Drosophila muscle tissue

Authors: Ziwei Zhao, David Brooks, Yungui Guo, Erika R Geisbrecht

Journal: Genetics

PubMed ID: 37713608

Doi: 10.1093/genetics/iyad167

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Arabidopsis calmodulin-like proteins CML13 and CML14 interact with calmodulin-binding transcriptional activators and function in salinity stress response

Authors: Bryan Hau, Kyle Symonds, Howard Teresinski, Abby Janssen, Liam Duff, Milena Smith, Kirsten Benidickson, William Plaxton, Wayne A Snedden

Journal: Plant Cell Physiol

PubMed ID: 38036467

Doi: 10.1093/pcp/pcad152

Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors

Authors: Jin Chen, Lingjun Zhang, Maojing Yang, Elizabeth D Hughes, Zach Freeman, Thomas L Saunders, Feng Lin

Journal: J Innate Immun

PubMed ID: 38035563

Doi: 10.1159/000534963

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FGFR1 expression correlates inversely with the efficacy of single-agent FGFR-specific inhibitors in pancreatic cancer

Authors: Qingxiang Lin, Andrea Serratore, Jonathan Perri, Tista Roy Chaudhuri, Jun Qu, Wen Wee Ma, Eugene Kandel, Robert M Straubinger

Journal: Br J Pharmacol

PubMed ID: 37994108

Doi: 10.1111/bph.16289

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Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

Authors: Shudan Tan, Jinghua Zhao, Xue Hu, Yufeng Li, Zihan Wu, Guoliang Lu, Zhaoli Yu, Binhe Du, Yan Liu, Li Li, Yuchen Chen, Ye Li, Yanfeng Yao, Xiaoyu Zhang, Juhong Rao, Ge Gao, Yun Peng, Hang Liu, Zhiming Yuan, Jia Liu, Qianran Wang, Hengrui Hu, Xiaobo Gao, Hui Zhou, Hang Yu, Yingjie Xu, Wei Yu, Lin Feng, Manli Wang, Chao Shan, Jing Lu, Jinzhong Lin

Journal: Sci Bull (Beijing)

PubMed ID: 37993332

Doi: 10.1016/j.scib.2023.11.024

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