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Propagation of conformational instability in FK506-binding protein FKBP12

Authors: David M LeMaster, Qamar Bashir, Griselda Hernández

Journal: Biochim Biophys Acta Proteins Proteom

PubMed ID: 38142946

Doi: 10.1016/j.bbapap.2023.140990

Products & Services: Proteins, Expression, Isolation and Analysis

A bioengineered anti-VEGF protein with high affinity and high concentration for intravitreal treatment of wet age-related macular degeneration

Authors: Chengnan Huang, Yuelin Wang, Jinliang Huang, Huiqin Liu, Zhidong Chen, Yang Jiang, Youxin Chen, Feng Qian

Journal: Bioeng Transl Med

PubMed ID: 38435828

Doi: 10.1002/btm2.10632

Products & Services: Recombinant Proteins

MAT2A inhibition suppresses inflammation in -infected human gingival fibroblasts

Authors: Lishan Jiang, Jingwen Li, Kun Ji, Lang Lei, Houxuan Li

Journal: J Oral Microbiol

PubMed ID: 38130504

Doi: 10.1080/20002297.2023.2292375

Products & Services: Molecular Biology Reagents

Identification of as a novel regulator of carfilzomib resistance in multiple myeloma

Authors: Jie Zhao, Xuantao Yang, Haixi Zhang, Xuezhong Gu

Journal: Oncol Res

PubMed ID: 38186567

Doi: 10.32604/or.2023.030770

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering to produce -muconic acid from biomass aromatics

Authors: Avery C Vilbert, Wayne S Kontur, Derek Gille, Daniel R Noguera, Timothy J Donohue

Journal: Appl Environ Microbiol

PubMed ID: 38117061

Doi: 10.1128/aem.01660-23

Products & Services: Molecular Biology Reagents

Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8 T cells in persons with previous COVID-19

Authors: Emily S Ford, Koshlan Mayer-Blackwell, Lichen Jing, Kerry J Laing, Anton M Sholukh, Russell St Germain, Emily L Bossard, Hong Xie, Thomas H Pulliam, Saumya Jani, Stacy Selke, Carlissa J Burrow, Christopher L McClurkan, Anna Wald, Alexander L Greninger, Michael R Holbrook, Brett Eaton, Elizabeth Eudy, Michael Murphy, Elena Postnikova, Harlan S Robins, Rebecca Elyanow, Rachel M Gittelman, Matyas Ecsedi, Elise Wilcox, Aude G Chapuis, Andrew Fiore-Gartland, David M Koelle

Journal: Nat Immunol

PubMed ID: 38057617

Doi: 10.1038/s41590-023-01692-x

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Association of LOX gene G473A polymorphism with the occurrence of allergic rhinitis and efficacy of montelukast sodium in children

Authors: Xikun Yao, Yan Liu, Hong Jiao, Wenjie Ma, Minliang Chen

Journal: Cell Cycle

PubMed ID: 38009683

Doi: 10.1080/15384101.2023.2286802

Products & Services: Proteins, Expression, Isolation and Analysis

MscI restriction enzyme cooperating recombinase-aided isothermal amplification for the ultrasensitive and rapid detection of low-abundance EGFR mutations on microfluidic chip

Authors: Shiqi Xu, Xinjie Wang, Chengyuan Wu, Xueting Zhu, Xinyi Deng, Yue Wu, Ming Liu, Xingxu Huang, Lina Wu, He Huang

Journal: Biosens Bioelectron

PubMed ID: 38134625

Doi: 10.1016/j.bios.2023.115925

Products & Services: Proteins, Expression, Isolation and Analysis

A Replication-Competent Retroviral Vector Expressing the HERV-W Envelope Glycoprotein is a Potential Tool for Cancer Gene Therapy

Authors: Byoung Kwon Kang, Yong-Tae Jung

Journal: J Microbiol Biotechnol

PubMed ID: 38247210

Doi: 10.4014/jmb.2309.09022

Products & Services: Gene Synthesis

ACE2-Fc and DPP4-Fc decoy receptors against SARS-CoV-2 and MERS-CoV variants: a quick therapeutic option for current and future coronaviruses outbreaks

Authors: Mohamed A Alfaleh, Reem M Alsulaiman, Sarah A Almahboub, Leena Nezamuldeen, Ayat Zawawi, Najwa D Aljehani, Muhammad Yasir, Rwaa H Abdulal, Rami Alkhaldi, Assala Helal, Sawsan S Alamri, Jana Malki, Rowa Y Alhabbab, Turki S Abujamel, Nabil A Alhakamy, Aisha Alnami, Abdullah Algaissi, Mazen Hassanain, Anwar M Hashem

Journal: Antib Ther

PubMed ID: 38371953

Doi: 10.1093/abt/tbad030

Products & Services: Codon Optimization

Safinamide alleviates hyperalgesia via inhibiting hyperexcitability of DRG neurons in a mouse model of Parkinson's disease

Authors: Li-Ge Zhang, Jing Cheng, Meng-Qi An, Cheng-Jie Li, Li-Guo Dong, Jian-Min Wang, Chun-Feng Liu, Fen Wang, Cheng-Jie Mao

Journal: Behav Brain Res

PubMed ID: 38042302

Doi: 10.1016/j.bbr.2023.114787

Products & Services: Gene Synthesis

A nanobody inhibiting porcine reproductive and respiratory syndrome virus replication via blocking self-interaction of viral nucleocapsid protein

Authors: Hong Duan, Xu Chen, Ziwei Zhang, Zhijie Zhang, Zhihan Li, Xinjie Wang, Jiakai Zhao, Yuchen Nan, Baoyuan Liu, Angke Zhang, Yani Sun, Qin Zhao

Journal: J Virol

PubMed ID: 38084961

Doi: 10.1128/jvi.01319-23

Products & Services: Proteins, Expression, Isolation and Analysis

Novel role of peptidoglycan recognition protein 2 in activating NOD2-NFκB inflammatory axis in coronary artery disease

Authors: Pratitusti Basu, Apabrita Ayan Das, Khawer N Siddiqui, Prakas C Mondal, Arun Bandyopadhyay

Journal: Atherosclerosis

PubMed ID: 38277990

Doi: 10.1016/j.atherosclerosis.2023.117436

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Flagellar hook protein FlgE promotes macrophage activation and atherosclerosis by targeting ATP5B

Authors: Yuanyuan Li, Min Zhang, Yanmeng Li, Ying Shen, Xiaoping Wang, Xiaolu Li, Yiqiang Wang, Tao Yu, Jie Lv, Yan Qin

Journal: Atherosclerosis

PubMed ID: 38278062

Doi: 10.1016/j.atherosclerosis.2023.117429

Products & Services: Molecular Biology Reagents

A new vaccination regimen using adenovirus-vectored vaccine confers effective protection against African swine fever virus in swine

Authors: Wenming Liu , Hengchun Li , Bo Liu , Tianxing Lv , Chenchen Yang , Si Chen , Liqiang Feng , Liangxue Lai , Ziyuan Duan , Xinwen Chen , Pingchao Li , Suhua Guan , Ling Chen

Journal: Emerg Microbes Infect .

PubMed ID: 37401832

Doi: 10.1080/22221751.2023.2233643

Products & Services: Peptide Synthesis

The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

Authors: Meng-Kai Ge, Cheng Zhang, Na Zhang, Ping He, Hai-Yan Cai, Song Li, Shuai Wu, Xi-Li Chu, Yu-Xue Zhang, Hong-Ming Ma, Li Xia, Shuo Yang, Jian-Xiu Yu, Shi-Ying Yao, Xiao-Long Zhou, Bing Su, Guo-Qiang Chen, Shao-Ming Shen

Journal: Cell Metabolism

PubMed ID: 37979583

Doi: doi.org/10.1016/j.cmet.2023.10.016

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport

Authors: Bin Pang , Leiye Yu , Tong Li , Haizhan Jiao , Xiaomei Wu , Jinxin Wang , Ruiping He , Yurou Zhang , Juan Wang , Hongli Hu , Wei Dai , Li Chen , Ruobing Ren

Journal: Cell Res .

PubMed ID: 38123824

Doi: 10.1038/s41422-023-00908-x

Products & Services: GenCrispr Cas9 Genome Editing

Influence of a D-enantiomeric peptide on the anticorrosion ability of titanium with different surface roughness against Streptococcus mutans biofilms

Authors: Dan Wang, Jian Yu, He Liu, Tian Zhang, Evan F Haney, Robert E W Hancock, Lin Peng, Ya Shen

Journal: J Dent

PubMed ID: 37944630

Doi: 10.1016/j.jdent.2023.104777

Products & Services: Peptide Synthesis

Development of automated microfluidic immunoassays for the detection of SARS-CoV-2 antibodies and antigen

Authors: Linwood Johnson, Maggie L Bartlett, Francisco Ramirez, Christopher D Heger, Darci R Smith

Journal: J Immunol Methods

PubMed ID: 38040191

Doi: 10.1016/j.jim.2023.113586

Products & Services: Proteins, Expression, Isolation and Analysis

A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases

Authors: Nicholas W Ashton, Nancy Jaiswal, Natália Cestari Moreno, Irina V Semenova, Dana A D'Orlando, Marcela Teatin Latancia, Justyna McIntyre, Roger Woodgate, Irina Bezsonova

Journal: J Mol Biol

PubMed ID: 37935254

Doi: 10.1016/j.jmb.2023.168353

Products & Services: Proteins, Expression, Isolation and Analysis

Extramedullary hematopoiesis contributes to enhanced erythropoiesis during pregnancy via TGF-β signaling

Authors: Yao Fu, Zhengjuan Li, Wen Lin, Jingxin Yao, Xiang Jiang, Qun Shu, Xiaoyuan Mao, Jiaoqin Tu, Xinyuan Liang, Liping Li

Journal: Front Immunol

PubMed ID: 38045690

Doi: 10.3389/fimmu.2023.1295717

Products & Services: Molecular Biology Reagents

2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition

Authors: Marios Gavriil, Marco Proietto, Nicole Paczia, Aurelien Ginolhac, Rashi Halder, Elena Valceschini, Thomas Sauter, Carole L Linster, Lasse Sinkkonen

Journal: Life Sci Alliance

PubMed ID: 38011998

Doi: 10.26508/lsa.202302333

Products & Services: Codon Optimization

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Authors: Qi Tang, Hassan H Fakih, Mohammad Zain Ui Abideen, Samuel R Hildebrand, Khashayar Afshari, Katherine Y Gross, Jacquelyn Sousa, Allison S Maebius, Christina Bartholdy, Pia Pernille Søgaard, Malene Jackerott, Vignesh Hariharan, Ashley Summers, Xueli Fan, Ken Okamura, Kathryn R Monopoli, David A Cooper, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, Raymond C Furgal, Karen Dresser, Sarah J Winter, Annabelle Biscans, Jane Chuprin, Nazgol-Sadat Haddadi, Shany Sherman, Ümmügülsüm Yıldız-Altay, Mehdi Rashighi, Jillian M Richmond, Claire Bouix-Peter, Carine Blanchard, Adam Clauss, Julia F Alterman, Anastasia Khvorova, John E Harris

Journal: Nat Commun

PubMed ID: 37925520

Doi: 10.1038/s41467-023-42714-4

Products & Services: Peptide Synthesis

Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex

Authors: Matthias Breindl, Dominika Spitzer, Rūta Gerasimaitė, Visvaldas Kairys, Thomas Schubert, Ramona Henfling, Uwe Schwartz, Gražvydas Lukinavičius, Laura Manelytė

Journal: Nucleic Acids Res

PubMed ID: 38000389

Doi: 10.1093/nar/gkad1096

Products & Services: Gene Synthesis

A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response

Authors: Bella M Ben-Oz, Feras E Machour, Marian Nicola, Amir Argoetti, Galia Polyak, Rawad Hanna, Oded Kleifeld, Yael Mandel-Gutfreund, Nabieh Ayoub

Journal: Nat Commun

PubMed ID: 37993446

Doi: 10.1038/s41467-023-43495-6

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Linear motif specificity in signaling through p38α and ERK2 mitogen-activated protein kinases

Authors: Jaylissa Torres Robles, Hua Jane Lou, Guangda Shi, Pauline Lining Pan, Benjamin E Turk

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37988460

Doi: 10.1073/pnas.2316599120

Products & Services: Recombinant Proteins

Expression and characterization of novel chimeric endolysin CHAPk-SH3bk against biofilm-forming methicillin-resistant Staphylococcus aureus

Authors: Manisha Behera, Gagandeep Singh, Ashutosh Vats, Mayank Roshan, Devika Gautam, Chanchal Rana, Rajesh Kumar Kesharwani, Sachinandan De, Soma M Ghorai

Journal: Int J Biol Macromol

PubMed ID: 37944719

Doi: 10.1016/j.ijbiomac.2023.127969

Products & Services: Gene Synthesis

A sensitive luciferase reporter assay for the detection of infectious African swine fever virus

Authors: Kemal Mehinagic, Matthias Liniger, Maksym Samoilenko, Nick Soltermann, Markus Gerber, Nicolas Ruggli

Journal: J Virol Methods

PubMed ID: 37989458

Doi: 10.1016/j.jviromet.2023.114854

Products & Services: Molecular Biology Reagents

Engineering self-deliverable ribonucleoproteins for genome editing in the brain

Authors: Kai Chen, Elizabeth C Stahl, Min Hyung Kang, Bryant Xu, Ryan Allen, Marena Trinidad, Jennifer A Doudna

Journal: biorxiv

PubMed ID: 38014180

Doi: 10.1101/2023.11.15.567251

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Insights into Molecular Diversity within the FET Family: Unraveling Phase Separation of the N-Terminal Low Complexity Domain from RNA-Binding Protein EWS

Authors: Courtney N Johnson, Kandarp A Sojitra, Erich J Sohn, Alma K Moreno-Romero, Antoine Baudin, Xiaoping Xu, Jeetain Mittal, David S Libich

Journal: biorxiv

PubMed ID: 37961424

Doi: 10.1101/2023.10.27.564484

Products & Services: Proteins, Expression, Isolation and Analysis

Changes in intestinal flora of mice induced by rEgP29 epitope peptide vaccines

Authors: Tingting Zhang, Yongxue Lv, Yinqi Zhao, Jihui Yang, Bingshuo Qian, Yazhou Zhu, Wei Zhao, Mingxing Zhu

Journal: Immun Inflamm Dis

PubMed ID: 38018604

Doi: 10.1002/iid3.1082

Products & Services: Proteins, Expression, Isolation and Analysis

AR/RKIP pathway mediates the inhibitory effects of icariin on renal fibrosis and endothelial-to-mesenchymal transition in type 2 diabetic nephropathy

Authors: Wenhui Yao, Rongpin Tao, Yue Xu, Zhe-Sheng Chen, Xuansheng Ding, Lisheng Wan

Journal: J Ethnopharmacol

PubMed ID: 37977422

Doi: 10.1016/j.jep.2023.117414

Products & Services: Proteins, Expression, Isolation and Analysis

Application of machine learning algorithms to construct and validate a prediction model for coronary heart disease risk in patients with periodontitis: a population-based study

Authors: Yicheng Wang, Binghang Ni, Yuan Xiao, Yichang Lin, Yu Jiang, Yan Zhang

Journal: Front Cardiovasc Med

PubMed ID: 38094122

Doi: 10.3389/fcvm.2023.1296405

Products & Services: Proteins, Expression, Isolation and Analysis

Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response

Authors: Joel H Graber, Derick Hoskinson, Huiyun Liu, Katarzyna Kaczmarek Michaels, Peter S Benson, Nathaniel J Maki, Christian L Wilson, Caleb McGrath, Franco Puleo, Erika Pearson, Jason N Kuehner, Claire Moore

Journal: Genetics

PubMed ID: 37967370

Doi: 10.1093/genetics/iyad199

Products & Services: Proteins, Expression, Isolation and Analysis

Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

Authors: Nafiseh Sabri, Matthew J Cuneo, Melissa R Marzahn, Jihun Lee, Jill J Bouchard, Ömer Güllülü, Sivaraja Vaithiyalingam, Madeleine B Borgia, Jeremy Schmit, Tanja Mittag

Journal: J Biol Chem

PubMed ID: 37926283

Doi: 10.1016/j.jbc.2023.105427

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 ORF7a blocked autophagy flux by intervening in the fusion between autophagosome and lysosome to promote viral infection and pathogenesis

Authors: Shun Li, Xiaobo Li, Haowei Liang, Kuike Yu, Jingbo Zhai, Mengzhou Xue, Zhuojing Luo, Chunfu Zheng, Hao Zhang

Journal: J Med Virol

PubMed ID: 37916857

Doi: 10.1002/jmv.29200

Products & Services: Proteins, Expression, Isolation and Analysis

RING-type E3 ligase BnaJUL1 ubiquitinates and degrades BnaTBCC1 to regulate drought tolerance in Brassica napus L

Authors: Jin Hu, Mudan Luo, Xianming Zhou, Zhaoyang Wang, Li Yan, Dengfeng Hong, Guangsheng Yang, Xiaohui Zhang

Journal: Plant Cell Environ

PubMed ID: 37984059

Doi: 10.1111/pce.14770

Products & Services: Proteins, Expression, Isolation and Analysis

TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1

Authors: Hansol Heo, Hyungsun Park, Myung Shin Lee, Jongyoon Kim, Juyeong Kim, Soon-Young Jung, Sun Kyeon Kim, Seongju Lee, Jaerak Chang

Journal: Autophagy

PubMed ID: 38009729

Doi: 10.1080/15548627.2023.2287925

Products & Services: Proteins, Expression, Isolation and Analysis

Cancer Relevance of Circulating Antibodies Against LINE-1 Antigens in Humans

Authors: Alexandra V Vylegzhanina, Ivan A Bespalov, Ksenia A Novototskaya-Vlasova, Brandon M Hall, Anatoli S Gleiberman, Han Yu, Olga V Leontieva, Katerina I Leonova, Oleg V Kurnasov, Andrei L Osterman, Grace K Dy, Alexey A Komissarov, Elena Vasilieva, Jeff Gehlhausen, Akiko Iwasaki, Christine B Ambrosone, Takemasa Tsuji, Junko Matsuzaki, Kunle Odunsi, Ekaterina L Andrianova, Andrei V Gudkov

Journal: Cancer Res Commun

PubMed ID: 37870410

Doi: 10.1158/2767-9764.CRC-23-0289

Products & Services: Proteins, Expression, Isolation and Analysis

Increasing insight in the value of repetitive COVID-19 vaccination in patients with haematological malignancies in the Omicron era

Authors: Ulrike Bacher, Evgenii Shumilov, Thomas Pabst

Journal: Br J Haematol

PubMed ID: 37984996

Doi: 10.1111/bjh.19221

Products & Services: Proteins, Expression, Isolation and Analysis

OsALB3 Is Required for Chloroplast Development by Promoting the Accumulation of Light-Harvesting Chlorophyll-Binding Proteins in Rice

Authors: Chao Zhang, Xinchen Mao, Xiaoxiao Feng, Yali Sun, Zirui Wang, Jiaqi Tang, Hengxiu Yu

Journal: Plants (Basel)

PubMed ID: 38068638

Doi: 10.3390/plants12234003

Products & Services: Molecular Biology Reagents

Structure and functional divergence of PIP peptide family revealed by functional studies on PIP1 and PIP2 in

Authors: Xiao-Song Yu, Hong-Run Wang, Fei-Fan Lei, Rui-Qi Li, Hui-Peng Yao, Jin-Bo Shen, Noor-Ul Ain, Yi Cai

Journal: Front Plant Sci

PubMed ID: 38078092

Doi: 10.3389/fpls.2023.1208549

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Ligand-based targeting of c-kit using engineered γδ T cells as a strategy for treating acute myeloid leukemia

Authors: Gianna M Branella, Jasmine Y Lee, Jennifer Okalova, Kiran K Parwani, Jordan S Alexander, Raquel F Arthuzo, Andrew Fedanov, Bing Yu, David McCarty, Harrison C Brown, Shanmuganathan Chandrakasan, Brian G Petrich, Christopher B Doering, H Trent Spencer

Journal: Front Immunol

PubMed ID: 38022523

Doi: 10.3389/fimmu.2023.1294555

Products & Services: Combinatorial DNA Libraries

Substance P Increases STAT6-Mediated Transcription Activation of Lymphocyte Cytosolic Protein 2 to Sustain M2 Macrophage Predominance in Pediatric Asthma

Authors: Miao Li, Xiao Zhong, Wenting Xu

Journal: Am J Pathol

PubMed ID: 37995836

Doi: 10.1016/j.ajpath.2023.11.003

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Juvenile hormone induces reproduction via miR-1175-3p in the red imported fire ant, Solenopsis invicta

Authors: Jie Chen, Ziying Guan, Yunjie Ma, Qingxing Shi, Ting Chen, Muhammad Irfan Waris, Lihua Lyu, Yongyue Lu, Guojun Qi

Journal: Insect Sci

PubMed ID: 37933419

Doi: 10.1111/1744-7917.13291

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Biophysical and biochemical characterization of the thioredoxin system from Colwellia psychrerythraea

Authors: Naheda Sahtout, David A R Sanders

Journal: Proteins

PubMed ID: 37909486

Doi: 10.1002/prot.26627

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Mesenchymal stem cells attenuate systemic lupus erythematosus by inhibiting NLRP3 inflammasome activation through Pim-1 kinase

Authors: Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun

Journal: Int Immunopharmacol

PubMed ID: 37992447

Doi: 10.1016/j.intimp.2023.111256

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Human leukocyte antigen HLA-DR-expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis

Authors: Joseph R Rouse, Rebecca Danner, Amanda Wahhab, Michaela Pereckas, Mecaila E McClune, Allen C Steere, Klemen Strle, Brandon L Jutras, Robert B Lochhead

Journal: biorxiv

PubMed ID: 38045407

Doi: 10.1101/2023.11.21.568066

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NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Authors: Yves Dondelinger, Dario Priem, Jon Huyghe, Tom Delanghe, Peter Vandenabeele, Mathieu J M Bertrand

Journal: Cell Death Dis

PubMed ID: 37980412

Doi: 10.1038/s41419-023-06284-z

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Single-injection subunit vaccine for rabies prevention using lentinan as adjuvant

Authors: Xiaoyong Zhou, Haozheng Wang, Jianchen Zhang, Ying Guan, Yongjun Zhang

Journal: Int J Biol Macromol

PubMed ID: 37977452

Doi: 10.1016/j.ijbiomac.2023.128118

Products & Services: Proteins, Expression, Isolation and Analysis

Telomerase Upregulation Induces Progression of Mouse BrafV600E-Driven Thyroid Cancers and Triggers Nontelomeric Effects

Authors: Iñigo Landa, Caitlin E M Thornton, Bin Xu, Jacob Haase, Gnana P Krishnamoorthy, Jingzhu Hao, Jeffrey A Knauf, Zachary T Herbert, Paula Martínez, María A Blasco, Ronald Ghossein, James A Fagin

Journal: Mol Cancer Res

PubMed ID: 37478162

Doi: 10.1158/1541-7786.MCR-23-0144

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A glutamate-gated chloride channel as the mite-specific target-site of dicofol and other diphenylcarbinol acaricides

Authors: Marilou Vandenhole, Catherine Mermans, Berdien De Beer, Wenxin Xue, Yilan Zhao, Yoshihisa Ozoe, Genyan Liu, Wannes Dermauw, Thomas Van Leeuwen

Journal: Commun Biol

PubMed ID: 37957415

Doi: 10.1038/s42003-023-05488-5

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Conserved antigen structures and antibody-driven variations on foot-and-mouth disease virus serotype A revealed by bovine neutralizing monoclonal antibodies

Authors: Kun Li, Yong He, Li Wang, Pinghua Li, Huifang Bao, Shulun Huang, Shasha Zhou, Guoqiang Zhu, Yali Song, Ying Li, Sheng Wang, Qianliang Zhang, Pu Sun, Xingwen Bai, Zhixun Zhao, Zhiyong Lou, Yimei Cao, Zengjun Lu, Zaixin Liu

Journal: PLoS Pathog

PubMed ID: 37983290

Doi: 10.1371/journal.ppat.1011811

Products & Services: Proteins, Expression, Isolation and Analysis

Sulforaphene suppressed cell proliferation and promoted apoptosis of COV362 cells in endometrioid ovarian cancer

Authors: Hui-Yan Yu, Li Yang, Yuan-Cai Liu, Ai-Jun Yu

Journal: PeerJ

PubMed ID: 38025760

Doi: 10.7717/peerj.16308

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Extracellular and intracellular destruction of Pseudomonas aeruginosa by Dictyostelium discoideum phagocytes mobilize different antibacterial mechanisms

Authors: Imen Ayadi, Otmane Lamrabet, Raphael Munoz-Ruiz, Tania Jauslin, Cyril Guilhen, Pierre Cosson

Journal: Mol Microbiol

PubMed ID: 38017607

Doi: 10.1111/mmi.15197

Products & Services: Proteins, Expression, Isolation and Analysis

Isolation and characterization of the aspartame-degrading strain Pseudarthrobacter sp AS-1

Authors: Zhijian Ke, Junyun Song, Jingrui Ma, Mengting Wang, Haiguang Mao, Chunli Xia, Lili Qi, Yidong Zhou, Jinbo Wang

Journal: Environ Pollut

PubMed ID: 37944888

Doi: 10.1016/j.envpol.2023.122883

Products & Services: Gene Synthesis

Prenatal diagnostic approaches diagnosed craniosynostosis and identified a novel nonsense variant in SMAD6 in a Chinese fetus

Authors: Zhidan Hong, Xuanyi He, Jie Duan, Fang Yu, Huanyu Liu, Dan Lu, Mei Wang, Yuanzhen Zhang

Journal: Gene

PubMed ID: 37977316

Doi: 10.1016/j.gene.2023.147994

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A second-generation M1-polarized CAR macrophage with antitumor efficacy

Authors: Anhua Lei, Hua Yu, Shan Lu, Hengxing Lu, Xizhong Ding, Tianyu Tan, Hailing Zhang, Mengmeng Zhu, Lin Tian, Xudong Wang, Siyu Su, Dixuan Xue, Shaolong Zhang, Wei Zhao, Yuge Chen, Wanrun Xie, Li Zhang, Yuqing Zhu, Jing Zhao, Wenhong Jiang, George Church, Francis Ka-Ming Chan, Zhihua Gao, Jin Zhang

Journal: Nat Immunol

PubMed ID: 38012418

Doi: 10.1038/s41590-023-01687-8

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Role and mechanism of miR-871-3p/Megf8 in regulating formaldehyde-induced cardiomyocyte inflammation and congenital heart disease

Authors: Xiaoli Yuan, Rui Chen, Gang Luo, Pin Sun, Xiaoxia Song, Jianmin Ma, Ruicong Sun, Tao Yu, Zhirong Jiang

Journal: Int Immunopharmacol

PubMed ID: 38039718

Doi: 10.1016/j.intimp.2023.111297

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered immunogens to elicit antibodies against conserved coronavirus epitopes

Authors: A Brenda Kapingidza, Daniel J Marston, Caitlin Harris, Daniel Wrapp, Kaitlyn Winters, Dieter Mielke, Lu Xiaozhi, Qi Yin, Andrew Foulger, Rob Parks, Maggie Barr, Amanda Newman, Alexandra Schäfer, Amanda Eaton, Justine Mae Flores, Austin Harner, Nicholas J Catanzaro, Michael L Mallory, Melissa D Mattocks, Christopher Beverly, Brianna Rhodes, Katayoun Mansouri, Elizabeth Van Itallie, Pranay Vure, Brooke Dunn, Taylor Keyes, Sherry Stanfield-Oakley, Christopher W Woods, Elizabeth A Petzold, Emmanuel B Walter, Kevin Wiehe, Robert J Edwards, David C Montefiori, Guido Ferrari, Ralph Baric, Derek W Cain, Kevin O Saunders, Barton F Haynes, Mihai L Azoitei

Journal: Nat Commun

PubMed ID: 38036525

Doi: 10.1038/s41467-023-43638-9

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered IL-7 synergizes with IL-12 immunotherapy to prevent T cell exhaustion and promote memory without exacerbating toxicity

Authors: Seounghun Kang, Aslan Mansurov, Trevin Kurtanich, Hye Rin Chun, Anna J Slezak, Lisa R Volpatti, Kevin Chang, Thomas Wang, Aaron T Alpar, Kirsten C Refvik, O Isabella Hansen, Gustavo J Borjas, Ha-Na Shim, Kevin T Hultgren, Suzana Gomes, Ani Solanki, Jun Ishihara, Melody A Swartz, Jeffrey A Hubbell

Journal: Sci Adv

PubMed ID: 38019919

Doi: 10.1126/sciadv.adh9879

Products & Services: Proteins, Expression, Isolation and Analysis

Jianpi Huayu Decoction suppresses cellular senescence in colorectal cancer via p53-p21-Rb pathway: Network pharmacology and in vivo validation

Authors: Shiting Wang, Ying Xing, Ruiping Wang, Zhichao Jin

Journal: J Ethnopharmacol

PubMed ID: 37931831

Doi: 10.1016/j.jep.2023.117347

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Structure-activity studies of Streptococcus pyogenes enzyme SpyCEP reveal high affinity for CXCL8 in the SpyCEP C-terminal

Authors: Max Pearson, Carl Haslam, Andrew Fosberry, Emma J Jones, Mark Reglinski, Lucy Reeves, Robert J Edwards, Richard Ashley Lawrenson, Jonathan C Brown, Danuta Mossakowska, James Edward Pease, Shiranee Sriskandan

Journal: Sci Rep

PubMed ID: 37923786

Doi: 10.1038/s41598-023-46036-9

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Safety and efficacy of the intranasal spray SARS-CoV-2 vaccine dNS1-RBD: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Authors: Fengcai Zhu, Shoujie Huang, Xiaohui Liu, Qi Chen, Chunlan Zhuang, Hui Zhao, Jinle Han, Anjuli May Jaen, Thai Hung Do, Jonathan Grant Peter, Alexander Gonzalez Dorado, Louie S Tirador, Gelza Mae A Zabat, Ralph Elvi M Villalobos, Gemalyn Pineda Gueco, Lauren Livia Greta Botha, Shirley Patricia Iglesias Pertuz, Jiaxiang Tan, Kongxin Zhu, Jiali Quan, Hongyan Lin, Yue Huang, Jizong Jia, Xiafei Chu, Junyu Chen, Yixin Chen, Tianying Zhang, Yingying Su, Changgui Li, Xiangzhong Ye, Ting Wu, Jun Zhang, Ningshao Xia

Journal: Lancet Respir Med

PubMed ID: 37979588

Doi: 10.1016/S2213-2600(23)00349-1

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Experimental co-infection of calves with SARS-CoV-2 Delta and Omicron variants of concern

Authors: Konner Cool, Natasha N Gaudreault, Jessie D Trujillo, Igor Morozov, Chester D McDowell, Dashzeveg Bold, Taeyong Kwon, Velmurugan Balaraman, Patricia Assato, Daniel W Madden, Emily Mantlo, Jayme Souza-Neto, Franco Matias-Ferreyra, Jaime Retallick, Gagandeep Singh, Michael Schotsaert, Mariano Carossino, Udeni B R Balasuriya, William C Wilson, Roman M Pogranichniy, Adolfo García-Sastre, Juergen A Richt

Journal: Emerg Microbes Infect

PubMed ID: 37938158

Doi: 10.1080/22221751.2023.2281356

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RAGE Is a Receptor for SARS-CoV-2 N Protein and Mediates N Protein-induced Acute Lung Injury

Authors: Jie Xia, Jiangmei Wang, Liyang Ying, Ruoqiong Huang, Kai Zhang, Ruoyang Zhang, Wenqi Tang, Qi Xu, Dengming Lai, Yan Zhang, Yaoqin Hu, Xiaodie Zhang, Ruoxi Zang, Jiajie Fan, Qiang Shu, Jianguo Xu

Journal: Am J Respir Cell Mol Biol

PubMed ID: 37478333

Doi: 10.1165/rcmb.2022-0351OC

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ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells

Authors: Meng Bian, Shan Li, Hanzong Zhou, Lijun Bi, Yong Shen, Chen Tingjin, Xinbing Yu, Yan Huang, Qingxia Xu

Journal: PLoS Negl Trop Dis

PubMed ID: 37948465

Doi: 10.1371/journal.pntd.0011727

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Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2)

Authors: Jingbo Yi, Boya Qi, Jian Yin, Ruochong Li, Xudong Chen, Junhan Hu, Guohui Li, Sensen Zhang, Yuebin Zhang, Maojun Yang

Journal: Nat Commun

PubMed ID: 38012235

Doi: 10.1038/s41467-023-43580-w

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Structure-directed bioengineering the lid1 of cold-adapted Pseudomonas sp TB11 esterase to boost catalytic capacity

Authors: Linlin Sha, Wen-Sen He, Tian Zheng, Yang Fei, Yu Fang, Huqing Yang, Gang Chen

Journal: Int J Biol Macromol

PubMed ID: 37992944

Doi: 10.1016/j.ijbiomac.2023.128302

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MiR126-targeted-nanoparticles combined with PI3K/AKT inhibitor as a new strategy to overcome melanoma resistance

Authors: Maria Beatrice Arasi, Gabriele De Luca, Laura Chronopoulou, Francesca Pedini, Eleonora Petrucci, Michela Flego, Annarita Stringaro, Marisa Colone, Luca Pasquini, Massimo Spada, Valentina Lulli, Maria Chiara Perrotta, George Adrian Calin, Cleofe Palocci, Mauro Biffoni, Federica Felicetti, Nadia Felli

Journal: Mol Ther

PubMed ID: 37990493

Doi: 10.1016/j.ymthe.2023.11.021

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Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences

Authors: Shane Kelly, Katherine Jl Jackson, Timothy J Peters, Dan Suan, Christopher C Goodnow

Journal: J Autoimmun

PubMed ID: 37952292

Doi: 10.1016/j.jaut.2023.103129

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Denovo production of resveratrol by engineered Saccharomyces cerevisiae W303-1a using pretreated Gracilaria corticata extracts

Authors: Nishanthika Thenmozhi Kulasekaran, Mary Leema Thilakam, Dharani Gopal, Jung-Kul Lee, Jeya Marimuthu

Journal: Biotechnol Lett

PubMed ID: 37987932

Doi: 10.1007/s10529-023-03441-4

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Development of a highly efficient prime editor system in mice and rabbits

Authors: Yuqiang Qian , Di Wang , Wenchao Niu , Zheng Shi , Mao Wu , Ding Zhao , Jinze Li , Xun Gao , Zhongtian Zhang , Liangxue Lai , Zhanjun Li

Journal: Cell Mol Life Sci .

PubMed ID: 37924393

Doi: 10.1007/s00018-023-05003-3

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Interactions of Histone Deacetylase 6 with DNA Damage Repair Factors Strengthen its Utility as a Combination Drug Target in High-Grade Serous Ovarian Cancer

Authors: Jolene M Duda, Stefani N Thomas

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38107255

Doi: 10.1021/acsptsci.3c00215

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Critical role of TPRN rings in the stereocilia for hearing

Authors: Jieyu Qi, Fangzhi Tan, Liyan Zhang, Yinyi Zhou, Ziyu Zhang, Qiuhan Sun, Nianci Li, Yuan Fang, Xin Chen, Yunhao Wu, Guisheng Zhong, Renjie Chai

Journal: Mol Ther

PubMed ID: 37952086

Doi: 10.1016/j.ymthe.2023.11.011

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DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones

Authors: Meital Abayev-Avraham, Yehuda Salzberg, Dar Gliksberg, Meital Oren-Suissa, Rina Rosenzweig

Journal: Nat Commun

PubMed ID: 37923706

Doi: 10.1038/s41467-023-42735-z

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A role for cytoglobin in regulating intracellular hydrogen peroxide and redox signals in the vasculature

Authors: Clinton Mathai, Frances Jourd'heuil, Le Gia Cat Pham, Kurrim Gilliard, Joseph Balnis, Annie Jen, Katherine A Overmyer, Joshua J Coon, Ariel Jaitovich, Benoit Boivin, David Jourd'heuil

Journal: biorxiv

PubMed ID: 37034694

Doi: 10.1101/2023.03.31.535146

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Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment

Authors: Xiang Dong, Chunlu Li, Chengsi Deng, Jingwei Liu, Danni Li, Tingting Zhou, Xindi Yang, Yunchan Liu, Qiqiang Guo, Yanling Feng, Yang Yu, Zhuo Wang, Wendong Guo, Siyi Zhang, Hongyan Cui, Cui Jiang, Xiwen Wang, Xiaoyu Song, Xun Sun, Liu Cao

Journal: Oncogene

PubMed ID: 37952080

Doi: 10.1038/s41388-023-02886-1

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A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease

Authors: Fernando Gonzalez-Ortiz, Pamela C L Ferreira, Armand González-Escalante, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R Kac, Michael Turton, Hlin Kvartsberg, Nicholas J Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, Tharick A Pascoal, Mary Ganguli, Anne D Cohen, Carolina Minguillon, Jose Contador, Marc Suárez-Calvet, Thomas K Karikari, Kaj Blennow

Journal: Alzheimers Dement

PubMed ID: 37975513

Doi: 10.1002/alz.13525

Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis

Authors: Ryan S Nett, Yaereen Dho, Chun Tsai, Daria Passow, Jaime Martinez Grundman, Yun-Yee Low, Elizabeth S Sattely

Journal: Nature

PubMed ID: 37938780

Doi: 10.1038/s41586-023-06716-y

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Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering

Authors: Derek Lee, Zachary Spencer Dunn, Wenbin Guo, Carl J Rosenthal, Natalie E Penn, Yanqi Yu, Kuangyi Zhou, Zhe Li, Feiyang Ma, Miao Li, Tsun-Ching Song, Xinjian Cen, Yan-Ruide Li, Jin J Zhou, Matteo Pellegrini, Pin Wang, Lili Yang

Journal: Nat Commun

PubMed ID: 37938576

Doi: 10.1038/s41467-023-42619-2

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Phages overcome bacterial immunity via diverse anti-defence proteins

Authors: Erez Yirmiya, Azita Leavitt, Allen Lu, Adelyn E Ragucci, Carmel Avraham, Ilya Osterman, Jeremy Garb, Sadie P Antine, Sarah E Mooney, Samuel J Hobbs, Philip J Kranzusch, Gil Amitai, Rotem Sorek

Journal: Nature

PubMed ID: 37992756

Doi: 10.1038/s41586-023-06869-w

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A streamlined, automated workflow to screen and triage large numbers of baculoviruses for protein expression

Authors: James J Kostas, Andrea T Partridge, Noel J Byrne, Richard W Edwards, Hua-Poo Su, Sandra B Gabelli, Alexei Brooun, Jennifer M Shipman

Journal: Protein Expr Purif

PubMed ID: 37995943

Doi: 10.1016/j.pep.2023.106406

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Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus

Authors: So Jin Bing, Morten Seirup, Trish T Hoang, Susana S Najera, Collin Britten, Stephanee L Warrington, Shiang-Ling Chu, Ronit Mazor

Journal: Nat Biomed Eng

PubMed ID: 37996615

Doi: 10.1038/s41551-023-01129-8

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Yeast Metabolic Engineering for Biosynthesis of Caffeic Acid-Derived Phenethyl Ester and Phenethyl Amide

Authors: Zi-Chen Jia, Duo Liu, Hai-Di Ma, Yu-Hui Cui, Hui-Min Li, Xia Li, Ying-Jin Yuan

Journal: ACS Synth Biol

PubMed ID: 38016187

Doi: 10.1021/acssynbio.3c00413

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Development of a multi-epitope vaccine candidate for leishmanial parasites applying immunoinformatics and approaches

Authors: Rahila Qureshi, Insaf Ahmed Qureshi

Journal: Front Immunol

PubMed ID: 38035118

Doi: 10.3389/fimmu.2023.1269774

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Environment relevant exposure of perfluorooctanoic acid accelerates the growth of hepatocellular carcinoma cells through mammalian target of rapamycin (mTOR) signal pathway

Authors: Jiawei Hong, Xiaoyan Wang, Hangbiao Jin, Yuanchen Chen, Yifan Jiang, Keyi Du, Diyu Chen, Shusen Zheng, Linping Cao

Journal: Environ Pollut

PubMed ID: 37967710

Doi: 10.1016/j.envpol.2023.122910

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Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products

Authors: Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori

Journal: Biotechnol Appl Biochem

PubMed ID: 38010900

Doi: 10.1002/bab.2538

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Development of an Electrochemical, Aptamer-Based Sensor for Dynamic Detection of Neuropeptide Y

Authors: Jordan M Seibold, Sanduni W Abeykoon, Ashley E Ross, Ryan J White

Journal: ACS Sens

PubMed ID: 38033269

Doi: 10.1021/acssensors.3c00855

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Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption

Authors: Jin-Gang Yang, Bao Sun, Zheng Wang, Xing Li, Jia-Hui Gao, Jia-Jun Qian, Jiang Li, Wen-Jia Wei, Ping Zhang, Wei Wang

Journal: Cell Death Dis

PubMed ID: 37957146

Doi: 10.1038/s41419-023-06263-4

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The Peroxidase gene OsPrx114 Activated by OsWRKY50 Enhances Drought Tolerance through ROS Scavenging in Rice

Authors: Chao Zheng , Xuming Wang , Yue Xu , Shaomin Wang , Xin Jiang e , Xiuli Liub , Weijun Cui , Yueyan Wu , Chengqi Yan , Hongjia Liu , Yin Lu e, Jianping Chen a,b, and Jie Zhou

Journal: Plant Physiology and Biochemistry

Doi: 10.1016/j.plaphy.2023.108138

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Unraveling the salt tolerance of Phi29 DNA polymerase using compartmentalized self-replication and microfluidics platform

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yaping Gao , Qiwen Zhang , Salem Baldi , Tao Hong , Igor Ivanov , Yun He , Hui Tian

Journal: Front Microbiol .

PubMed ID: 38029082

Doi: 10.3389/fmicb.2023.1267196

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Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region

Authors: Qinhong Luo , Yue Ma , Huiting Liang , Yuan Feng , Na Liu, Chenshan Lian , Lizhi Zhu , Yuxin Ye , Zhihong Liu , Zhanfeng Hou , Sijin Chen , Yaqi Wang , Chuan Dai , Chunli Song , Min Zhang , Zhipeng He , Yun Xing , Wanjin Zhong , Shuiming Li , Jianlong Wu , Fei Lu , Feng Yin , Zigang Li

Journal: J Med Chem .

PubMed ID: 37922441

Doi: 10.1021/acs.jmedchem.3c01549

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Structural insights into asymmetric activation of the calciumsensing receptor–Gq complex

Authors: Shenglong Ling, Xianyu Meng, Yuan Zhang, Zhemin Xia, Yingxin Zhou, Fan Yang, Pan Shi, Chaowei Shi, Changlin Tian

Journal: Cell Res .

PubMed ID: 37919470

Doi: 10.1038/s41422-023-00892-2

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Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite

Authors: Rahul Singh Rawat, Ankit Gupta, Neelam Antil, Sonika Bhatnagar, Monika Singh, Akanksha Rawat, T S Keshava Prasad, Pushkar Sharma