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Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects

Authors: Jingan Chen, Yue Xu, Muye Zhou, Shufen Xu, Andrew James Varley, Alex Golubovic, Rick Xing Ze Lu, Kevin Chang Wang, Mina Yeganeh, Daniel Vosoughi, Bowen Li

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38060560

Doi: 10.1073/pnas.2309472120

Products & Services: Molecular Biology Reagents

The role of CE16 exo-deacetylases in hemicellulolytic enzyme mixtures revealed by the biochemical and structural study of the novel TtCE16B esterase

Authors: Christina Pentari, Anastasia Zerva, Christos Kosinas, Panagiota Karampa, Vladimír Puchart, Maria Dimarogona, Evangelos Topakas

Journal: Carbohydr Polym

PubMed ID: 38171682

Doi: 10.1016/j.carbpol.2023.121667

Products & Services: Molecular Biology Reagents

A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis

Authors: Helena Port, Cecilie Møller Hausgaard, Yi He, Walter P Maksymowych, Stephanie Wichuk, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Signe Holm Nielsen

Journal: Sci Rep

PubMed ID: 38066013

Doi: 10.1038/s41598-023-48787-x

Products & Services: Proteins, Expression, Isolation and Analysis

Rapid detection of in sputum using CRISPR-Cas12b combined with cross-priming amplification in a single reaction

Authors: Lijun Peng, Tingting Fang, Qingshan Cai, Hao Li, Huanyu Li, Haiqiong Sun, Mingzhi Zhu, Lingshan Dai, Yanqin Shao, Long Cai

Journal: J Clin Microbiol

PubMed ID: 38112450

Doi: 10.1128/jcm.00923-23

Products & Services: Molecular Biology Reagents

Development of a double-antibody sandwich enzyme-linked immunosorbent assay for rapid detection of VZV

Authors: Aiping Wang, Na Liu, Jianguo Zhao, Yan Niu, Yumei Chen, Jingming Zhou, Enping Liu, Gaiping Zhang

Journal: J Virol Methods

PubMed ID: 38154579

Doi: 10.1016/j.jviromet.2023.114874

Products & Services: Molecular Biology Reagents

Superior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

Authors: Jaime S Rosa Duque, Samuel M S Cheng, Carolyn A Cohen, Daniel Leung, Xiwei Wang, Xiaofeng Mu, Yuet Chung, Tsun Ming Lau, Manni Wang, Wenyue Zhang, Yanmei Zhang, Howard H W Wong, Leo C H Tsang, Sara Chaothai, Tsz Chun Kwan, John K C Li, Karl C K Chan, Leo L H Luk, Jenson C H Ho, Wing Yan Li, Amos M T Lee, Jennifer H Y Lam, Sau Man Chan, Wilfred H S Wong, Issan Y S Tam, Masashi Mori, Sophie A Valkenburg, Malik Peiris, Wenwei Tu, Yu Lung Lau

Journal: World J Pediatr

PubMed ID: 38085470

Doi: 10.1007/s12519-023-00764-0

Products & Services: Serology SARS-Cov-2 detection kits

Intracellular cholesterol visualization in brain tissue using D4H

Authors: Sherida M de Leeuw, Tal Nuriel

Journal: STAR Protoc

PubMed ID: 38100357

Doi: 10.1016/j.xpro.2023.102779

Products & Services: Recombinant Proteins

Molecular Characterization of Tick-borne Pathogens in Bactrian Camels and Ticks from Gansu Province, China

Authors: Hong-Xi Zhao, Xiao-Qing Zan, Jin-Zhong Tao, Xin-Gang Dan

Journal: Acta Parasitol

PubMed ID: 38087038

Doi: 10.1007/s11686-023-00752-4

Products & Services: Recombinant Proteins

Purification of Human Cytoplasmic Actins From

Authors: Brian K Haarer, David C Amberg, Jessica L Henty-Ridilla

Journal: Bio Protoc

PubMed ID: 38094253

Doi: 10.21769/BioProtoc.4894

Products & Services: Catalog Peptides

Efficacy of cyclobutrifluram in controlling Fusarium crown rot of wheat and resistance risk of three Fusarium species to cyclobutrifluram

Authors: Haiyan Sun, Shiyan Cai, Yuanyu Deng, Shulin Cao, Xiaoyue Yang, Yanteng Lu, Wei Li, Huaigu Chen

Journal: Pestic Biochem Physiol

PubMed ID: 38225078

Doi: 10.1016/j.pestbp.2023.105723

Products & Services: Molecular Biology Reagents

Plant-based meat analogues enhance the gastrointestinal motility function and appetite of mice by specific volatile compounds and peptides

Authors: Yunting Xie, Linlin Cai, Mengzhen Ding, Kai Shan, Di Zhao, Guanghong Zhou, Chunbao Li

Journal: Food Research International

Doi: 10.1016/j.foodres.2023.113551

Products & Services: Gene Synthesis

Authors: Ewa Hordyjewska-Kowalczyk, Wim Wuyts, Nele Boeckx, An Verdonck, Gretl Hendrickx, Geert Mortier

Journal: Clin Genet

PubMed ID: 38108099

Doi: 10.1111/cge.14474

Products & Services: Proteins, Expression, Isolation and Analysis

The nuclease-associated short prokaryotic Argonaute system nonspecifically degrades DNA upon activation by target recognition

Authors: Xueling Lu, Jun Xiao, Longfei Wang, Bin Zhu, Fengtao Huang

Journal: Nucleic Acids Res

PubMed ID: 38048327

Doi: 10.1093/nar/gkad1145

Products & Services: Proteins, Expression, Isolation and Analysis

The global transcription regulator XooClp governs Type IV pili system mediated bacterial virulence by directly binding to their promoters to coordinate virulence associated functions

Authors: Raj Kumar Verma, Parimala Gondu, Tirthankar Saha, Subhadeep Chatterjee

Journal: Mol Plant Microbe Interact

PubMed ID: 38105438

Doi: 10.1094/MPMI-07-23-0100-R

Products & Services: Proteins, Expression, Isolation and Analysis

"Stronger than I thought I was": Older Adults' Coping across Two Years of the COVID-19 Pandemic

Authors: Heather R Fuller, Andrea Huseth-Zosel, Emily Kinkade, Bryce Van Vleet, Melisa Hajdar

Journal: Gerontologist

PubMed ID: 38109780

Doi: 10.1093/geront/gnad164

Products & Services: Codon Optimization

Expression of the non-neuronal cholinergic system components in Malpighian tubules of Mythimna separata and evidence for non-neuronal acetylcholine synthesis

Authors: Baolei Zhan, Ting Zhou, Di Tong, Zile Xu, Xiaoyu Liang, Anqi Ma, Shumin Lü

Journal: Insect Biochem Mol Biol

PubMed ID: 38072082

Doi: 10.1016/j.ibmb.2023.104047

Products & Services: Molecular Biology Reagents

The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7

Authors: Donald Van Ryk, Sinmanus Vimonpatranon, Joe Hiatt, Sundar Ganesan, Nathalie Chen, Jordan McMurry, Saadiq Garba, Susie Min, Livia R Goes, Alexandre Girard, Jason Yolitz, Isabella Licavoli, Danlan Wei, Dawei Huang, Marcelo A Soares, Elena Martinelli, Claudia Cicala, James Arthos

Journal: PLoS Pathog

PubMed ID: 38064524

Doi: 10.1371/journal.ppat.1011860

Products & Services: Gene Synthesis

RIF1 regulates early replication timing in murine B cells

Authors: Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N Klein, Mariia Nazarova, Ursula E Schoeberl, David M Gilbert, Sara C B Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri

Journal: Nat Commun

PubMed ID: 38081811

Doi: 10.1038/s41467-023-43778-y

Products & Services: Proteins, Expression, Isolation and Analysis

Factors influencing COVID-19 mortality among cancer patients: A Brazilian multi-institutional study

Authors: Jessé Lopes da Silva, Bruno Santos Wance de Souza, Lucas Zanetti de Albuquerque, Sabina Bandeira Aleixo, Gilmara Anne da Silva Resende, Daniela Galvão Barros de Oliveira, Emerson Neves Dos Santos, Angélica Nogueira-Rodrigues, Renan Orsati Clara, Maria de Fatima Dias Gaui, Augusto Cesar de Andrade Mota, Vladmir Claudio Cordeiro de Lima, Daniela Dornelles Rosa, Rodrigo Ramella Munhoz, Igor Alexandre Protzner Morbeck, Ana Caroline Zimmer Gelatti, Clarissa Maria de Cerqueira Mathias, Andréia Cristina de Melo

Journal: PLoS ONE

PubMed ID: 38127882

Doi: 10.1371/journal.pone.0295597

Products & Services: Molecular Biology Reagents

Evaluation of immunogenicity-induced DNA vaccines against different SARS-CoV-2 variants

Authors: Se Eun Kim, So Hee Park, Woo-Jung Park, Gayeong Kim, Seo Yeon Kim, Hyeran Won, Yun-Ho Hwang, Heeji Lim, Hyeon Guk Kim, You-Jin Kim, Dokeun Kim, Jung-Ah Lee

Journal: PLoS ONE

PubMed ID: 38060612

Doi: 10.1371/journal.pone.0295594

Products & Services: Plasmid DNA Preparation

Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation

Authors: Hongchen Zhang, Yuan Feng, Yanfang Si, Chuanhao Lu, Juan Wang, Shiquan Wang, Liang Li, Wenyu Xie, Zheming Yue, Jia Yong, Shuhui Dai, Lei Zhang, Xia Li

Journal: Redox Biol

PubMed ID: 38064762

Doi: 10.1016/j.redox.2023.102983

Products & Services: Proteins, Expression, Isolation and Analysis

Screening of novel DPP-IV inhibitory peptides derived from bovine milk proteins using a peptide array platform

Authors: Sayuri Arai, Masaki Kurimoto, Hajime Nakada, Masayoshi Tanaka, Hiroshi Ochi, Miyuki Tanaka, Mina Okochi

Journal: J Biosci Bioeng

PubMed ID: 38092600

Doi: 10.1016/j.jbiosc.2023.11.007

Products & Services: Catalog Peptides

Anti-inflammatory effects of neuregulin-1 in HaCaT keratinocytes and atopic dermatitis-like mice stimulated with Der p 38

Authors: Jeong Hee Yun, Yujin Hong, Min Hwa Hong, Geunyeong Kim, Ji-Sook Lee, Ran-Sook Woo, Juram Lee, Eun Ju Yang, In Sik Kim

Journal: Cytokine

PubMed ID: 38134557

Doi: 10.1016/j.cyto.2023.156439

Products & Services: Molecular Biology Reagents

Overlapping characteristics of weak interactions of two transcriptional regulators with WDR5

Authors: Mohammad Ahmad, Ali Imran, Liviu Movileanu

Journal: Int J Biol Macromol

PubMed ID: 38158065

Doi: 10.1016/j.ijbiomac.2023.128969

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a fluorescent multiplexed lateral flow immunoassay for the simultaneous detection of crustacean allergen tropomyosin, sarcoplasmic calcium binding protein and egg allergen ovalbumin in different matrices and commercial foods

Authors: Yuhao Huang, Ranran Li, Wenye Zhu, Jinlong Zhao, Hao Wang, Ziye Zhang, Hong Lin, Wenjie Li, Zhenxing Li

Journal: Food Chem

PubMed ID: 38150909

Doi: 10.1016/j.foodchem.2023.138275

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted HBx gene editing by CRISPR/Cas9 system effectively reduces epithelial to mesenchymal transition and HBV replication in hepatoma cells

Authors: Preety Rawal, Dinesh Mani Tripathi, Hamed Hemati, Jitendra Kumar, Purnima Tyagi, Shiv Kumar Sarin, Vikrant Nain, Savneet Kaur

Journal: Liver Int

PubMed ID: 38105495

Doi: 10.1111/liv.15805

Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22 STAT3 AKT pathway

Authors: Jiali Wang , Xianhai He , Zhirong Jia , Aiwen Yan , Kang Xiao , Shuo Liu , Mengjun Hou , Yaling Long , Xuansheng Ding

Journal: Pharm Biol .

PubMed ID: 38100532

Doi: 10.1080/13880209.2023.2292266

Products & Services: PCR Cloning and Subcloning

A KDPG sensor RccR governs Pseudomonas aeruginosa carbon metabolism and aminoglycoside antibiotic tolerance

Authors: Yujue Wang , Zhipeng Wang , Weizhong Chen , Ze-Hui Ren , Hui Gao , Jiani Dai , Guan-Zheng Luo , Zhaowei Wu , Quanjiang Ji

Journal: Nucleic Acids Res .

PubMed ID: 38096062

Doi: 10.1093/nar/gkad1201

Products & Services: Molecular Biology Reagents

Synthetic High-Density Lipoprotein-Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma

Authors: Chunrong Yang , Yujie Li , Yuchen Yang , Qiankun Ni , Zeyu Zhang , Yi Chai , Jinghong Li

Journal: Angew Chem Int Ed Engl .

PubMed ID: 37847126

Doi: 10.1002/anie.202312603

Products & Services: Peptide Synthesis

Structure and mechanism of a eukaryotic ceramide synthase complex

Authors: Tian Xie , Qi Fang , Zike Zhang , Yanfei Wang , Feitong Dong , Xin Gong

Journal: EMBO J .

PubMed ID: 37953642

Doi: 10.15252/embj.2023114889

Products & Services: Proteins, Expression, Isolation and Analysis

Biguanide chitosan microneedles with cell-free DNA scavenging ability for psoriasis therapy

Authors: Zihao Liu , Yu Wang , Yuhan Zhang , Liufu Hu , Bozhi Chen , Yang Li , Xindong Guo , Bingran Yu , Fu-Jian Xu

Journal: Bioactive Materials

Doi: 10.1016/j.bioactmat.2023.11.015

Products & Services: Gene Synthesis

Elevated BMI reduces the humoral response to SARS-CoV-2 infection

Authors: Marcus Zw Tong, Julian Dj Sng, Meagan Carney, Lucy Cooper, Samuel Brown, Katie E Lineburg, Keng Yih Chew, Neve Collins, Kirsten Ignacio, Megan Airey, Lucy Burr, Briony A Joyce, Dhilshan Jayasinghe, Christopher Ld McMillan, David A Muller, Anurag Adhikari, Linda A Gallo, Emily S Dorey, Helen L Barrett, Stephanie Gras, Corey Smith, Kim Good-Jacobson, Kirsty R Short

Journal: Clin Transl Immunology

PubMed ID: 38050635

Doi: 10.1002/cti2.1476

Products & Services: Molecular Biology Reagents

CD1d facilitates African swine fever virus entry into the host cells via clathrin-mediated endocytosis

Authors: Xin Chen, Jun Zheng, Chuanxia Liu, Tingting Li, Xiao Wang, Xuewen Li, Miaofei Bao, Jiangnan Li, Li Huang, Zhaoxia Zhang, Zhigao Bu, Changjiang Weng

Journal: Emerg Microbes Infect

PubMed ID: 37254454

Doi: 10.1080/22221751.2023.2220575

Products & Services: Molecular Biology Reagents

Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies

Authors: Tina Lusiany, Tohru Terada, Jun-Ichi Kishikawa, Mika Hirose, David Virya Chen, Fuminori Sugihara, Hendra Saputra Ismanto, Floris J van Eerden, Songling Li, Takayuki Kato, Hisashi Arase, Matsuura Yoshiharu, Masato Okada, Daron M Standley

Journal: Viruses

PubMed ID: 38140662

Doi: 10.3390/v15122421

Products & Services: Peptide Synthesis

Dissecting components of the gene cluster under iron limitation

Authors: Tomas Richardson-Sanchez, Anson C K Chan, Brendil Sabatino, Helen Lin, Erin C Gaynor, Michael E P Murphy

Journal: Microbiol Spectr

PubMed ID: 38096459

Doi: 10.1128/spectrum.03148-23

Products & Services: Gene Synthesis

Combining protein and metabolic engineering strategies for high-level production of L-theanine in Corynebacterium glutamicum

Authors: Taowei Yang, Di Zhang, Mengmeng Cai, Hengwei Zhang, Xuewei Pan, Jiajia You, Xian Zhang, Meijuan Xu, Zhiming Rao

Journal: Bioresour Technol

PubMed ID: 38103752

Doi: 10.1016/j.biortech.2023.130200

Products & Services: Gene Synthesis

Anxiety and dysautonomia symptoms in patients with a Na17 mutation and the potential benefits of low-dose short-acting guanfacine

Authors: Rita de Cássia Collaço, Maxime Lammens, Carley Blevins, Kristen Rodgers, Andrei Gurau, Suguru Yamauchi, Christine Kim, Jeannine Forrester, Edward Liu, Jinny Ha, Yuping Mei, Corrine Boehm, Elizabeth Wohler, Nara Sobreira, Peter C Rowe, David Valle, Malcolm V Brock, Frank Bosmans

Journal: Clin Auton Res

PubMed ID: 38064009

Doi: 10.1007/s10286-023-01004-1

Products & Services: Mutant Libraries

Development of a therapeutic monoclonal antibody against circulating adipocyte fatty acid binding protein to treat ischaemic stroke

Authors: Boya Liao, Shilun Yang, Leiluo Geng, Jiuyu Zong, Zixuan Zhang, Mengxue Jiang, Xue Jiang, Simeng Li, Aimin Xu, Junlei Chang, Ruby Lai Chong Hoo

Journal: Br J Pharmacol

PubMed ID: 37949671

Doi: 10.1111/bph.16282

Products & Services: Proteins, Expression, Isolation and Analysis

A randomized phase II study of acyclovir for the prevention of chemotherapy-induced oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation

Authors: Junshik Hong, Hee-Kyung Park, Sung-Ho Chang, Ja Min Byun, Dong-Yeop Shin, Youngil Koh, Sung-Soo Yoon, Youngnim Choi, Inho Kim

Journal: BMC Oral Health

PubMed ID: 38102638

Doi: 10.1186/s12903-023-03623-6

Products & Services: Proteins, Expression, Isolation and Analysis

Potential of Nano-Engineered Stem Cells in the Treatment of Multiple Sclerosis: A Comprehensive Review

Authors: Sushruta Ghosh, Gurjit Kaur Bhatti, Pushpender Kumar Sharma, Ramesh Kandimalla, Sarabjit Singh Mastana, Jasvinder Singh Bhatti

Journal: Cell Mol Neurobiol

PubMed ID: 38104307

Doi: 10.1007/s10571-023-01434-5

Products & Services: Codon Optimization

Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD

Authors: Zhefan Stephen Chen, Mingxi Ou, Stephanie Taylor, Ruxandra Dafinca, Shaohong Isaac Peng, Kevin Talbot, Ho Yin Edwin Chan

Journal: Nat Commun

PubMed ID: 38110419

Doi: 10.1038/s41467-023-44215-w

Products & Services: Gene Synthesis

A semi-quantitative upconversion nanoparticle-based immunochromatographic assay for SARS-CoV-2 antigen detection

Authors: Hai Ding, Wanying Zhang, Shu-An Wang, Chuang Li, Wanting Li, Jing Liu, Fang Yu, Yanru Tao, Siyun Cheng, Hui Xie, Yuxin Chen

Journal: Front Microbiol

PubMed ID: 38149276

Doi: 10.3389/fmicb.2023.1289682

Products & Services: Proteins, Expression, Isolation and Analysis

Template and target-site recognition by human LINE-1 in retrotransposition

Authors: Akanksha Thawani, Alfredo Jose Florez Ariza, Eva Nogales, Kathleen Collins

Journal: Nature

PubMed ID: 38096901

Doi: 10.1038/s41586-023-06933-5

Products & Services: Molecular Biology Reagents

Differential activation of mouse and human Panx1 channel variants

Authors: Antonio Cibelli, Preeti Dohare, David C Spray, Eliana Scemes

Journal: PLoS ONE

PubMed ID: 38100403

Doi: 10.1371/journal.pone.0295710

Products & Services: Proteins, Expression, Isolation and Analysis

Mucosal SARS-CoV-2 vaccination of rodents elicits superior systemic T central memory function and cross-neutralising antibodies against variants of concern

Authors: Aled O'Neill, Chinmay Kumar Mantri, Chee Wah Tan, Wilfried A A Saron, Santhosh Kambaiah Nagaraj, Monica Palanichamy Kala, Christy Margarat Joy, Abhay P S Rathore, Shashank Tripathi, Lin-Fa Wang, Ashley L St John

Journal: EBioMedicine

PubMed ID: 38113758

Doi: 10.1016/j.ebiom.2023.104924

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Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

Authors: Fanchong Jian, Leilei Feng, Sijie Yang, Yuanling Yu, Lei Wang, Weiliang Song, Ayijiang Yisimayi, Xiaosu Chen, Yanli Xu, Peng Wang, Lingling Yu, Jing Wang, Lu Liu, Xiao Niu, Jing Wang, Tianhe Xiao, Ran An, Yao Wang, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

Journal: PLoS Pathog

PubMed ID: 38117863

Doi: 10.1371/journal.ppat.1011868

Products & Services: Proteins, Expression, Isolation and Analysis

A lipid membrane-centric role of the SQSTM1/p62 body during autophagosome formation

Authors: Jinpei Zhang, Xintong He, Na Mi

Journal: Autophagy

PubMed ID: 38115546

Doi: 10.1080/15548627.2023.2297622

Products & Services: Plasmid DNA Preparation

DNA methylation editing in zebrafish

Authors: Fang Liang, Zijiong Dong, Jianmin Ye, Wei Hu, Ramji Kumar Bhandari, Kangsen Mai, Xuegeng Wang

Journal: Epigenetics

PubMed ID: 36945831

Doi: 10.1080/15592294.2023.2192326

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Antibody Response to SARS-CoV-2 Vaccination in Patients with End-Stage Kidney Disease on Hemodialysis

Authors: Rizky Andhika, Muhammad Iqbal Anand, Marita Restie Tiara, Josephine Debora, Hofiya Djauhari, Evan Susandi, Adnes Mareta, Asep Riswoko, Nopi Susilawati, Agnes Rengga Indrati, Bachti Alisjahbana, Rudi Supriyadi

Journal: Vaccines (Basel)

PubMed ID: 38140206

Doi: 10.3390/vaccines11121802

Products & Services: Plasmids for SARS-CoV-2 Detection and Research

, an AP2 and B3 Transcription Factor, Positively Regulates Eggplant's Response to Salt Stress

Authors: Junjie Ding, Bowen Yao, Xu Yang, Lei Shen

Journal: Plants (Basel)

PubMed ID: 38140500

Doi: 10.3390/plants12244174

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Computational design of scFv anti-receptor binding domain of SARS-CoV-2 spike protein based on antibody S230 anti-SARS-CoV-1

Authors: Ade R R Firdaus, Umi Baroroh, Taufik Ramdani Tohari, Ari Hardianto, Toto Subroto, Muhammad Yusuf

Journal: J Biomol Struct Dyn

PubMed ID: 37880854

Doi: 10.1080/07391102.2023.2265485

Products & Services: Proteins, Expression, Isolation and Analysis

High-resolution HLA genotyping in inclusion body myositis refines 81 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain

Authors: Nataliya Slater, Anuradha Sooda, Emily McLeish, Kelly Beer, Anna Brusch, Rakesh Shakya, Christine Bundell, Ian James, Abha Chopra, Frank L Mastaglia, Merrilee Needham, Jerome D Coudert

Journal: J Autoimmun

PubMed ID: 38043487

Doi: 10.1016/j.jaut.2023.103150

Products & Services: Proteins, Expression, Isolation and Analysis

Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response

Authors: Mengchen Lu, Jianai Ji, Yifei Lv, Jing Zhao, Yuting Liu, Qiong Jiao, Tian Liu, Yi Mou, Qidong You, Zhengyu Jiang

Journal: Cell Chem Biol

PubMed ID: 38157852

Doi: 10.1016/j.chembiol.2023.12.005

Products & Services: PCR Cloning and Subcloning

Generation and Characterization of an Influenza D Reporter Virus

Authors: Lukas Probst, Laura Laloli, Manon Flore Licheri, Matthias Licheri, Mitra Gultom, Melle Holwerda, Philip V'kovski, Ronald Dijkman

Journal: Viruses

PubMed ID: 38140686

Doi: 10.3390/v15122444

Products & Services: Proteins, Expression, Isolation and Analysis

Cas9 degradation in human cells using phage anti-CRISPR proteins

Authors: Zuriah Meacham, Luisa Arake de Tacca, Joseph Bondy-Denomy, David Rabuka, Michael Schelle

Journal: PLoS Biol

PubMed ID: 38064533

Doi: 10.1371/journal.pbio.3002431

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Copper assisted sequence-specificchemical protein conjugation at a single backbone amide

Authors: Mengzhun Guo , Kai Zhao , Liang Guo , Rui Zhou , Qiuju He , Kuan Lu , Tian Li, Dandan Liu , Jinfeng Chen , Jing Tang , Xin Fu , Jinyun Zhou , Bei Zheng , Samuel I Mann , Yongdeng Zhang , Jing Huang , Bing Yang , Ting Zhou , Yingjie Lei , Bobo Dang

Journal: Nat Commun

PubMed ID: 38052794

Doi: 10.1038/s41467-023-43753-7

Products & Services: Proteins, Expression, Isolation and Analysis

Revitalizing Skin Repair: Unveiling the Healing Power of Livisin, a Natural Peptide Calcium Mimetic

Authors: Xuehui Zhan, Danni Wang, Hanfei Wang, Hui Chen, Xinyi Wu, Tao Li, Junmei Qi, Tianbao Chen, Di Wu, Yitian Gao

Journal: Toxins

PubMed ID: 38251238

Doi: 10.3390/toxins16010021

Products & Services: Peptide Synthesis

Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD

Authors: Yulei Li, Peipei Liu, Tianjiao Hao, Sheng Liu, Xi Wang, Yufeng Xie, Ke Xu, Wenwen Lei, Cheng Zhang, Pu Han, Ying Li, Xiyue Jin, Yu Huan, Yafei Lu, Rong Zhang, Xiaoyan Li, Xin Zhao, Kun Xu, Pu Liao, Xuancheng Lu, Yuhai Bi, Hao Song, Guizhen Wu, Baoli Zhu, George F Gao

Journal: Emerg Microbes Infect

PubMed ID: 37394992

Doi: 10.1080/22221751.2023.2231573

Products & Services: Gene Synthesis

Anti-virulence and bactericidal activities of Stattic against Shigella sonnei

Authors: Mingfang Wang, Jia Zeng, Huihui Tan, Quan Guo, Xia Li, Xiwen Ling, Jinyue Zhang, Shihao Song, Yinyue Deng

Journal: Appl Environ Microbiol .

PubMed ID: 38032177

Doi: 10.1128/aem.01074-23

Products & Services: Proteins, Expression, Isolation and Analysis

Glucose-primed PEEK orthopedic implants for antibacterial therapy and safeguarding diabetic osseointegration

Authors: Miaomiao He, Hao Wang, Qiuyang Han, Xiuyuan Shi, Shuai He, Jiyu Sun, Zhuoli Zhu, Xueqi Gan, Yi Deng

Journal: Biomaterials

PubMed ID: 37948855

Doi: 10.1016/j.biomaterials.2023.122355

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A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity

Authors: Daniel Stern, Tanja C Meyer, Fridolin Treindl, Hans Werner Mages, Maren Krüger, Martin Skiba, Jan Philipp Krüger, Christian M Zobel, Maximilian Schreiner, Marica Grossegesse, Thomas Rinner, Caroline Peine, Anna Stoliaroff-Pépin, Thomas Harder, Natalie Hofmann, Janine Michel, Andreas Nitsche, Silke Stahlberg, Antje Kneuer, Anna Sandoni, Ulrike Kubisch, Martin Schlaud, Annette Mankertz, Tatjana Schwarz, Victor M Corman, Marcel A Müller, Christian Drosten, Kathrin de la Rosa, Lars Schaade, Martin B Dorner, Brigitte G Dorner

Journal: Sci Rep

PubMed ID: 38071261

Doi: 10.1038/s41598-023-48581-9

Products & Services: Proteins, Expression, Isolation and Analysis

Infliximab aggregates produced in severe and mild elevated temperature stress conditions induce an extended specific CD4 T-cell response

Authors: Myriam Nabhan, Sylvain Meunier, Victor Le-Minh, Baptiste Robin, Marie de Bourayne, Claire Smadja, Bernard Maillère, Marc Pallardy, Isabelle Turbica

Journal: Eur J Pharm Sci

PubMed ID: 38070782

Doi: 10.1016/j.ejps.2023.106670

Products & Services: Proteins, Expression, Isolation and Analysis

Gene-based COVID-19 vaccines: Australian perspectives in a corporate and global context

Authors: Peter Rhodes, Peter Parry

Journal: Pathol Res Pract

PubMed ID: 38101158

Doi: 10.1016/j.prp.2023.155030

Products & Services: Proteins, Expression, Isolation and Analysis

Mezigdomide is effective alone and in combination with Menin inhibition in pre-clinical models of KMT2A-r and NPM1c AML

Authors: Wallace Bourgeois, Jevon A Cutler, Brandon J Aubrey, Daniela Wenge, Florian Perner, Cynthia Martucci, Jill A Henrich, Kelly Klega, Radoslaw P Nowak, Katherine Aleisha Donovan, Meaghan Boileau, Yanhe Wen, Charles Hatton, Athina A Apazidis, Sarah N Olsen, Nadia Kirmani, Yana Pikman, Jessica A Pollard, Jennifer A Perry, Adam S Sperling, Benjamin L Ebert, Gerard M McGeehan, Brian D Crompton, Eric S Fischer, Scott A Armstrong

Journal: Blood

PubMed ID: 38096371

Doi: 10.1182/blood.2023021105

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Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules

Authors: Jiaqi Hu, Juling Jiang, Bowen Xu, Yue Li, Bei Wang, Shulin He, Xiaoling Ren, Bolun Shi, Xing Zhang, Honggang Zheng, Baojin Hua, Rui Liu

Journal: J Ethnopharmacol

PubMed ID: 38113986

Doi: 10.1016/j.jep.2023.117590

Products & Services: Proteins, Expression, Isolation and Analysis

Acid phosphatase-like proteins, a biogenic amine and leukotriene-binding salivary protein family from the flea Xenopsylla cheopis

Authors: Stephen Lu, John F Andersen, Christopher F Bosio, B Joseph Hinnebusch, José M Ribeiro

Journal: Commun Biol

PubMed ID: 38110569

Doi: 10.1038/s42003-023-05679-0

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Agonistic Bivalent Human scFvs-Fcγ Fusion Antibodies to OX40 Ectodomain Enhance T Cell Activities against Cancer

Authors: Kodchakorn Mahasongkram, Kantaphon Glab-Ampai, Kanasap Kaewchim, Thanatsaran Saenlom, Monrat Chulanetra, Nitat Sookrung, Oytip Nathalang, Wanpen Chaicumpa

Journal: Vaccines (Basel)

PubMed ID: 38140230

Doi: 10.3390/vaccines11121826

Products & Services: Recombinant Proteins

Efficient de novo production of bioactive cordycepin by Aspergillus oryzae using a food-grade expression platform

Authors: Sukanya Jeennor, Jutamas Anantayanon, Sarocha Panchanawaporn, Chanikul Chutrakul, Wanwipa Vongsangnak, Kobkul Laoteng

Journal: Microb Cell Fact

PubMed ID: 38071331

Doi: 10.1186/s12934-023-02261-5

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Resveratrol-derived inhibitors of the E3 ubiquitin ligase PELI1 inhibit the metastasis of triple-negative breast cancer

Authors: Guangsen Xu, Qian Zhou, Jie Qi, Zhongyue Li, Lijun Yin, Zhuoran Li, Chunhua Lu, Baobing Zhao, Yuemao Shen

Journal: Eur J Med Chem

PubMed ID: 38150964

Doi: 10.1016/j.ejmech.2023.116060

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Worsening of imiquimod-induced psoriasiform inflammation in mice by environmental pollutant, di-(2-ethylhexyl) phthalate through dysregulation in IL-17A and Nrf2/iNOS signaling in peripheral myeloid and CD4 + T cells

Authors: Ali S Alfardan, Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Mohammed Alqinyah, Sabry M Attia, Wedad Sarawi, Ahmed Z Alanazi, Khalid Alhazzani, Khalid E Ibrahim

Journal: Int Immunopharmacol

PubMed ID: 38056199

Doi: 10.1016/j.intimp.2023.111293

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Neuroprotective Effects of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) against Amyloid-β-Induced Alzheimer's Disease Mouse Model

Authors: Jawad Ali, Amjad Khan, Jun Sung Park, Muhammad Tahir, Waqas Ahmad, Kyonghwan Choe, Myeong Ok Kim

Journal: Nutrients

PubMed ID: 38068844

Doi: 10.3390/nu15234986

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Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets

Authors: Ricardo Cruz-Acuña, Secunda W Kariuki, Kensuke Sugiura, Spyros Karaiskos, Eleanor M Plaster, Claudia Loebel, Gizem Efe, Tatiana Karakasheva, Joel T Gabre, Jianhua Hu, Jason A Burdick, Anil K Rustgi

Journal: J Clin Invest

PubMed ID: 37788109

Doi: 10.1172/JCI168146

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An evolutionarily conserved serine protease network mediates melanization and Toll activation in

Authors: Tisheng Shan, Yang Wang, Krishna Bhattarai, Haobo Jiang

Journal: Sci Adv

PubMed ID: 38117884

Doi: 10.1126/sciadv.adk2756

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ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape

Authors: Tianyao Liu, Xinyan Xu, Jiazheng Li, Ming Bai, Wenjie Zhu, Yanqing Liu, Siyang Liu, Zihan Zhao, Tianhang Li, Ning Jiang, Yuhao Bai, Qingyang Jin, Yulin Zhang, Yufeng Zheng, Shengkai Zhou, Shoubin Zhan, Ying Sun, Gaoli Liang, Yang Luo, Xi Chen, Hongqian Guo, Rong Yang

Journal: Cell Death Dis

PubMed ID: 38062004

Doi: 10.1038/s41419-023-06333-7

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Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

Authors: Huan Wang, Syed R A Rizvi, Danni Dong, Jiaqi Lou, Qian Wang, Watanyoo Sopipong, Yufeng Su, Fares Najar, Pratul K Agarwal, Frank Kozielski, Shozeb Haider

Journal: Elife

PubMed ID: 38127066

Doi: 10.7554/eLife.87884

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The density of anionic lipids modulates the adsorption of α-Synuclein onto lipid membranes

Authors: Alexandra Andersson, Sara Linse, Emma Sparr, Marco Fornasier, Peter Jönsson

Journal: Biophys Chem

PubMed ID: 38100855

Doi: 10.1016/j.bpc.2023.107143

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Metabolic signatures of tear extracellular vesicles caused by herpes simplex keratitis

Authors: Huixiang Ma, Tucan Chen, Chengxu Li, Hao Xu, Qingyu Feng, Yunfei Su, Jianqiu Cai, Qingfu Zhu, Fei Liu, Liang Hu

Journal: Ocul Surf

PubMed ID: 38122863

Doi: 10.1016/j.jtos.2023.12.005

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Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways

Authors: Qiao Liu, Qingman Luo, Bin Zhong, Kecheng Tang, Xueling Chen, Shengqian Yang, Xiaohui Li

Journal: Eur J Pharmacol

PubMed ID: 38048979

Doi: 10.1016/j.ejphar.2023.176236

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The egg ribonuclease SjCP1412 accelerates liver fibrosis caused by infection involving damage-associated molecular patterns (DAMPs)

Authors: Qi-Feng Li, Yi-Xin Li, Ying-Ying Yang, Pan-Pan Dong, Cong-Jin Mei, Ju-Lu Lu, Jian-Feng Zhang, Hai-Yong Hua, Chun-Rong Xiong, Chuan-Xin Yu, Li-Jun Song, Kun Yang

Journal: Parasitology

PubMed ID: 38105713

Doi: 10.1017/S0031182023001361

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The OsBZR1-OsSPX1/2 Module Fine-tunes Growth-Immunity Trade-off in Adaptation to Pi Availability in Rice

Authors: Yuqing He , Yao Zhao , Jitao Hu , Lanlan Wang , Linying Li , Xueying Zhang , Zhongjing Zhou , Lili Chen , Hua Wang , Jiaoyu Wang , Gaojie Hong

Journal: Mol Plant .

PubMed ID: 38069474

Doi: 10.1016/j.molp.2023.12.003

Products & Services: Proteins, Expression, Isolation and Analysis

α-Synuclein emulsifies TDP-43 prion-like domain-RNA liquid droplets to promote heterotypic amyloid fibrils

Authors: Shailendra Dhakal, Malay Mondal, Azin Mirzazadeh, Siddhartha Banerjee, Ayanjeet Ghosh, Vijayaraghavan Rangachari

Journal: Commun Biol

PubMed ID: 38052886

Doi: 10.1038/s42003-023-05608-1

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Redeveloping antigen detection kits for the diagnosis of rat hepatitis E virus

Authors: Zihao Chen, Guanghui Li, Jianwen Situ, Zhiyong Li, Shaoqi Guo, Yang Huang, Shusheng Wu, Zimin Tang, Guiping Wen, Siling Wang, Mujin Fang, Yingbin Wang, Hai Yu, Siddharth Sridhar, Zizheng Zheng, Ningshao Xia

Journal: J Clin Microbiol

PubMed ID: 38038482

Doi: 10.1128/jcm.00710-23

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Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ25 complexes in the context of celiac disease

Authors: Yuu Okura, Yuri Ikawa-Teranishi, Akihiko Mizoroki, Noriyuki Takahashi, Takashi Tsushima, Machiko Irie, Zulkarnain Harfuddin, Momoko Miura-Okuda, Shunsuke Ito, Genki Nakamura, Hiroaki Takesue, Yui Ozono, Masamichi Nishihara, Kenta Yamada, Siok Wan Gan, Akira Hayasaka, Shinya Ishii, Tetsuya Wakabayashi, Masaru Muraoka, Nishiki Nagaya, Hiroshi Hino, Takayuki Nemoto, Taichi Kuramochi, Takuya Torizawa, Hideaki Shimada, Takehisa Kitazawa, Makoto Okazaki, Junichi Nezu, Ludvig M Sollid, Tomoyuki Igawa

Journal: Nat Commun

PubMed ID: 38135691

Doi: 10.1038/s41467-023-44083-4

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Protocol for precision editing of endogenous Chlamydomonas reinhardtii genes with CRISPR-Cas

Authors: Adrian Pascal Nievergelt, Dennis Ray Diener, Aliona Bogdanova, Thomas Brown, Gaia Pigino

Journal: STAR Protoc

PubMed ID: 38096061

Doi: 10.1016/j.xpro.2023.102774

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Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients

Authors: Jean-Pierre Bellier, Yuqi Cai, Sarah M Alam, Thorsten Wiederhold, Arica Aiello, Jonathan S Vogelgsang, Sabina Berretta, Jasmeer P Chhatwal, Dennis J Selkoe, Lei Liu

Journal: Alzheimers Dement

PubMed ID: 38041855

Doi: 10.1002/alz.13557

Products & Services: Proteins, Expression, Isolation and Analysis

Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs

Authors: Wenyan Han, Hou-Yuan Qiu, Shangwu Sun, Zhi-Can Fu, Guo-Quan Wang, Xiaowen Qian, Lijie Wang, Xiaowen Zhai, Jia Wei, Yichuan Wang, Yi-Lin Guo, Guo-Hua Cao, Rui-Jin Ji, Yi-Zhou Zhang, Hongxia Ma, Hongsheng Wang, Mingli Zhao

Journal: Cell Stem Cell

PubMed ID: 37989316

Doi: 10.1016/j.stem.2023.10.007

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A plasmid containing the human metallothionein-II gene selectively distinguishes trivalent lanthanum from several divalent heavy metal cations during monoclonal antibody-assisted agarose gel electrophoresis

Authors:

Journal: Toxicol Ind Health

PubMed ID: 38095284

Doi: 10.1177/07482337231222354

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Activation and characterization of G protein-coupled receptors for CHHs in the mud crab, Scylla paramamosain

Authors: Nan Mo, Shucheng Shao, Yan Zhuang, Yanan Yang, Zhaoxia Cui, Chenchang Bao

Journal: Comp Biochem Physiol A Mol Integr Physiol

PubMed ID: 38122925

Doi: 10.1016/j.cbpa.2023.111563

Products & Services: Proteins, Expression, Isolation and Analysis

Diverse nature of ClpX degradation motifs in

Authors: Vivek Gurung, Saswati Biswas, Indranil Biswas

Journal: Microbiol Spectr

PubMed ID: 38051052

Doi: 10.1128/spectrum.03457-23

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Akt may associate with insulin-responsive vesicles via interaction with sortilin

Authors: Nava Zaarur, Anatoli B Meriin, Maneet Singh, Raghuveera K Goel, Joseph Zaia, Konstantin V Kandror

Journal: FEBS Lett

PubMed ID: 38105115

Doi: 10.1002/1873-3468.14790

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A General and Convenient Peptide Self-Assembling Mechanism for Developing Supramolecular Versatile Nanomaterials Based on The Biosynthetic Hybrid Amyloid-Resilin Protein

Authors: Junjun Wu, Lin Zhou, Hu Peng, Zhaojun Wang, Zhaoshi Wang, Jay D Keasling, Shike Liu, Guanghong Zhou, Shijie Ding, Qiong Wang, Xuejian Wang, Xinxiu Chen, Yifei Lang, Mo Xia, Xin Guan, Mingsheng Dong, Jingwen Zhou, Jian Chen

Journal: Adv Mater

PubMed ID: 37885340

Doi: 10.1002/adma.202304364

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Immunogenicity Persistence of a Third-Dose Homologous BBIBP-CorV/CoronaVac Boosting Vaccination: A Prospective Open-Label Study

Authors: Na Ren, Zhihong Wang, Sikang Gao

Journal: Viral Immunol

PubMed ID: 38109058

Doi: 10.1089/vim.2023.0075

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Pro-osteogenic role of interleukin-22 in calcific aortic valve disease

Authors: Huifang Deng, Huadong Li, Zongtao Liu, Na Shen, Nianguo Dong, Cheng Deng, Fayuan Liu

Journal: Atherosclerosis

PubMed ID: 38104486

Doi: 10.1016/j.atherosclerosis.2023.117424

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Ferricyanide-promoted Oxidative Activation and Ligation of Protein Thioacids in Neutral Aqueous Media

Authors: Guo-Chao Chu, Lu-Jun Liang, Rui Zhao, Yan-Yan Guo, Chun-Tong Li, Chong Zuo, Huasong Ai, Xiao Hua, Zi-Chen Li, Yi-Ming Li, Lei Liu

Journal: CCS Chemistry

Doi: 10.31635/ccschem.023.202303397

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Immunoswitch Nanomodulators Enable Active Targeting and Selective Proliferation of Regulatory T Cells for Multiple Sclerosis Therapy

Authors: Xiaoshuang Wang , Zhilin Liu , Di Wang , Yingyu Zhang , Honglei Zhang , Fuxin Xue , Xianhong Wang , Zhaohui Tang , Xuemei Han

Journal: ACS Nano .

PubMed ID: 38113242

Doi: 10.1021/acsnano.3c09225

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In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma

Authors: Qiang Cheng, Lukas Farbiak, Amogh Vaidya, Erick Guerrero, Eunice E Lee, Elysha K Rose, Xu Wang, Joshua Robinson, Sang M Lee, Tuo Wei, William E Miller, Ester Alvarez Benedicto, Xizhen Lian, Richard C Wang, Daniel J Siegwart

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38109533

Doi: 10.1073/pnas.2313009120

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Suppression of overactive IGF-1 attenuates trauma-induced heterotopic ossification in mice

Authors: Dong Mao, Kai Wang, Hong Jiang, Jingyi Mi, Xiaoyun Pan, Gang Zhao, Yongjun Rui

Journal: Am J Pathol

PubMed ID: 38101566

Doi: 10.1016/j.ajpath.2023.11.012

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The p30 protein of the African swine fever virus behaves as an RNase

Authors: Satyendu Nandy, Nilave Ranjan Bora, Shubham Gaurav, Sachin Kumar

Journal: Virology

PubMed ID: 38086285

Doi: 10.1016/j.virol.2023.109967

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High levels of alpha-gal with large variation in the salivary glands of lone star ticks fed on human blood

Authors: L Paulina Maldonado-Ruiz, Kathryn E Reif, Anuradha Ghosh, Stephanie Foré, Rachel L Johnson, Yoonseong Park

Journal: Sci Rep

PubMed ID: 38049505

Doi: 10.1038/s41598-023-48437-2

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Publisher Correction: CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides

Authors: Guillaume Gaud, Sooraj Achar, François X P Bourassa, John Davies, Teri Hatzihristidis, Seeyoung Choi, Taisuke Kondo, Selamawit Gossa, Jan Lee, Paul Juneau, Naomi Taylor, Christian S Hinrichs, Dorian B McGavern, Paul François, Grégoire Altan-Bonnet, Paul E Love

Journal: Nat Immunol

PubMed ID: 38057618

Doi: 10.1038/s41590-023-01725-5

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