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The Anti-SARS-CoV-2 IgG1 and IgG3 Antibody Isotypes with Limited Neutralizing Capacity against Omicron Elicited in a Latin Population a Switch toward IgG4 after Multiple Doses with the mRNA Pfizer-BioNTech Vaccine

Authors: Ana M Espino, Albersy Armina-Rodriguez, Laura Alvarez, Carlimar Ocasio-Malavé, Riseilly Ramos-Nieves, Esteban I Rodriguez Martinó, Paola López-Marte, Esther A Torres, Carlos A Sariol

Journal: Viruses

PubMed ID: 38399963

Doi: 10.3390/v16020187

Products & Services: Molecular Biology Reagents

BBS genes are involved in accelerated proliferation and early differentiation of BBS-related tissues

Authors: Avital Horwitz, Noa Levi-Carmel, Olga Shnaider, Ruth Birk

Journal: Differentiation

PubMed ID: 38215537

Doi: 10.1016/j.diff.2024.100745

Products & Services: Molecular Biology Reagents

Cytoophidia Influence Cell Cycle and Size in

Authors: Ruolan Deng, Yi-Lan Li, Ji-Long Liu

Journal: Int J Mol Sci

PubMed ID: 38203781

Doi: 10.3390/ijms25010608

Products & Services: Proteins, Expression, Isolation and Analysis

Functional characterization of the dimeric form of PDGF-derived fusion peptide fabricated based on theoretical arguments

Authors: Maryam Sadeghi-Ardebili, Sadegh Hasannia, Bahareh Dabirmanesh, Ramazan Ali Khavari-Nejad

Journal: Sci Rep

PubMed ID: 38200288

Doi: 10.1038/s41598-024-51707-2

Products & Services: Peptide Synthesis

A small-molecule activation mechanism that directly opens the KCNQ2 channel

Authors: Shaoying Zhang, Demin Ma, Kun Wang, Ya Li, Zhenni Yang, Xiaoxiao Li, Junnan Li, Jiangnan He, Lianghe Mei, Yangliang Ye, Zongsheng Chen, Juwen Shen, Panpan Hou, Jiangtao Guo, Qiansen Zhang, Huaiyu Yang

Journal: Nat Chem Biol

PubMed ID: 38167918

Doi: 10.1038/s41589-023-01515-y

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Ewing Sarcoma Related protein 1 recognizes R-loops by binding DNA forks

Authors: Michelle A Lay, Valery F Thompson, Ajibola D Adelakun, Jacob C Schwartz

Journal: biorxiv

PubMed ID: 38293191

Doi: 10.1101/2024.01.20.576463

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A novel strategy for an anti-idiotype vaccine: nanobody mimicking neutralization epitope of porcine circovirus type 2

Authors: Yingying Deng, Yamin Sheng, Guixi Zhang, Yani Sun, Lei Wang, Pinpin Ji, Jiahong Zhu, Gang Wang, Baoyuan Liu, En-Min Zhou, Xuehui Cai, Yabin Tu, Julian A Hiscox, James P Stewart, Yang Mu, Qin Zhao

Journal: J Virol

PubMed ID: 38271227

Doi: 10.1128/jvi.01650-23

Products & Services: Proteins, Expression, Isolation and Analysis

Improved detection sensitivity of anti-PRV variant antibodies through preparation of anti-gB and anti-gE monoclonal antibodies and development of blocking ELISAs

Authors: Zhenyang Guo, Hu Xu, Siyu Zhang, Haonan Kang, Chao Li, Qi Sun, Jing Zhao, Jinhao Li, Guohui Zhou, Qian Wang, Lirun Xiang, Yandong Tang, Huairan Liu, Chaoliang Leng, Tongqing An, Xuehui Cai, Zhijun Tian, Hongliang Zhang, Jinmei Peng

Journal: Int J Biol Macromol

PubMed ID: 38219937

Doi: 10.1016/j.ijbiomac.2024.129425

Products & Services: Antibody Modification and Purification Services

ETHYLENE RESPONSE FACTOR 070 inhibits flowering in Pak-choi by indirectly impairing BcLEAFY expression

Authors: Zhanghong Yu , Xiaoshan Chen , Yan Li , Sayyed Hamad Ahmad Shah , Dong Xiao , Jianjun Wang , Xilin Hou , Tongkun Liu , Ying Li

Journal: Plant Physiol .

PubMed ID: 38269601

Doi: 10.1093/plphys/kiae021

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A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways

Authors: Zhibin Zhang , Xi Lin , Ling Wei , Yiran Wu , Lu Xu , Lijie Wu , Xiaohu Wei , Suwen Zhao, Xiangjia Zhu , Fei Xu

Journal: Cell Discov .

PubMed ID: 38182578

Doi: s41421-023-00627-y

Products & Services: Codon Optimization

LL‐37_Renalexin hybrid peptide exhibits antimicrobial activity at lower MICs than its counterpart single peptides

Authors: Julius Kwesi Narh , Nestor G Casillas-Vega , Xristo Zarate

Journal: Appl Microbiol Biotechnol .

PubMed ID: 38229302

Doi: 10.1007/s00253-023-12887-5

Products & Services: Gene Synthesis

High-Yield Expression and Purification of Scygonadin, an Antimicrobial Peptide, Using the Small Metal-Binding Protein SmbP

Authors: Jessica J. Gomez-Lugo 1 , Nestor G. Casillas-Vega , Alma Gomez-Loredo , Isaias Balderas-Renteria and Xristo Zarate

Journal: Microorganisms

Doi: 10.3390/microorganisms12020278

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Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain

Authors: Yanqun Wang, Zhaoyong Zhang, Minnan Yang, Xinyi Xiong, Qihong Yan, Lei Cao, Peilan Wei, Yuting Zhang, Lu Zhang, Kexin Lv, Jiantao Chen, Xuesong Liu, Xiaochu Zhao, Juxue Xiao, Shengnan Zhang, Airu Zhu, Mian Gan, Jingjun Zhang, Ruoxi Cai, Jianfen Zhuo, Yanjun Zhang, Haiyue Rao, Bin Qu, Yuanyuan Zhang, Lei Chen, Jun Dai, Linling Cheng, Qingtao Hu, Yaoqing Chen, Huibin Lv, Ray T Y So, Malik Peiris, Jingxian Zhao, Xiaoqing Liu, Chris Ka Pun Mok, Xiangxi Wang, Jincun Zhao

Journal: Cell Rep

PubMed ID: 38175758

Doi: 10.1016/j.celrep.2023.113653

Products & Services: Recombinant Proteins

A conserved protein inhibitor brings under check the activity of RNase E in cyanobacteria

Authors: Su-Juan Liu, Gui-Ming Lin, Yu-Qi Yuan, Wenli Chen, Ju-Yuan Zhang, Cheng-Cai Zhang

Journal: Nucleic Acids Res

PubMed ID: 38000383

Doi: 10.1093/nar/gkad1094

Products & Services: Proteins, Expression, Isolation and Analysis

Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice

Authors: Ying-Dan Zhang, Dong-Dong Shi, Bing-Bing Liao, Yi Li, Sen Zhang, Jian Gao, Liang-Jun Lin, Zhen Wang

Journal: Mol Psychiatry

PubMed ID: 38273106

Doi: 10.1038/s41380-024-02424-9

Products & Services: Proteins, Expression, Isolation and Analysis

Pharmacokinetic Analyses of a Lipid Nanoparticle-Encapsulated mRNA-Encoded Antibody against Rift Valley Fever Virus

Authors: Shuo Wang, Ziling Zhu, Jianmin Li

Journal: Mol Pharm

PubMed ID: 38295278

Doi: 10.1021/acs.molpharmaceut.3c01016

Products & Services: Proteins, Expression, Isolation and Analysis

Transition Metal Ion FRET-Based Probe to Study Cu(II)-Mediated Amyloid- Ligand Binding

Authors: Ri Wu, Despoina Svingou, Jonas B Metternich, Lukas R Benzenberg, Renato Zenobi

Journal: J Am Chem Soc

PubMed ID: 38225538

Doi: 10.1021/jacs.3c11533

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Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination

Authors: Autumn E Sanders, Henriette Arnesen, Frances K Shepherd, Dira S Putri, Jessica K Fiege, Mark J Pierson, Shanley N Roach, Harald Carlsen, David Masopust, Preben Boysen, Ryan A Langlois

Journal: mSphere

PubMed ID: 38286428

Doi: 10.1128/msphere.00654-23

Products & Services: Recombinant Proteins

Antibody reactive immunomes of and are diverse and defined by conformational antigenic determinants

Authors: Tian Luo, Jignesh G Patel, Xiaofeng Zhang, Jere W McBride

Journal: Front Cell Infect Microbiol

PubMed ID: 38264730

Doi: 10.3389/fcimb.2023.1321291

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Recombinantly expressed virus-like particles (VLPs) of canine circovirus for development of an indirect ELISA

Authors: Alison Neef, Babu Kanti Nath, Tridip Das, Daniel Luque, Jade K Forwood, Shane R Raidal, Shubhagata Das

Journal: Vet Res Commun

PubMed ID: 38163840

Doi: 10.1007/s11259-023-10290-z

Products & Services: Gene Synthesis

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

Authors: Edrees H Rashan, Abigail K Bartlett, Daven B Khana, Jingying Zhang, Raghav Jain, Andrew J Smith, Zakery N Baker, Taylor Cook, Alana Caldwell, Autumn R Chevalier, Brian F Pfleger, Peng Yuan, Daniel Amador-Noguez, Judith A Simcox, David J Pagliarini

Journal: biorxiv

PubMed ID: 38260250

Doi: 10.1101/2024.01.09.574893

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A glycoside hydrolase 30 protein BpXynC of Bacillus paralicheniformis NMSW12 recognized as A MAMP triggers plant immunity response

Authors: Chenjie Yu, Xiaoli Liang, Yan Song, Qurban Ali, Xihao Yang, Linli Zhu, Qin Gu, Vladislav Kuptsov, Emilia Kolomiets, Huijun Wu, Xuewen Gao

Journal: Int J Biol Macromol

PubMed ID: 38286384

Doi: 10.1016/j.ijbiomac.2024.129750

Products & Services: Mutant Libraries

N-acetyltransferase 10 regulates alphavirus replication via N4- acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA

Authors: Yamei Dang , Jia Li , Yuchang Li , Yuan Wang , Yajing Zhao , Ningbo Zhao , Wanying Li , Hui Zhang , Chuantao Ye , Hongwei Ma , Liang Zhang , He Liu , Yangchao Dong , Min Yao , Yingfeng Lei , Zhikai Xu , Fanglin Zhang , Wei Ye

Journal: J Virol .

PubMed ID: 38169284

Doi: 10.1128/jvi.01350-23

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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Authors: Gisele Nishiguchi , Lauren G Mascibroda , Sarah M Young , Elizabeth A Caine , Sherif Abdelhamed , Jeffrey J Kooijman , Darcie J Miller , Sourav Das , Kevin McGowan , Anand Mayasundari , Zhe Shi , Juan M Barajas , Ryan Hiltenbrand , Anup Aggarwal , Yunchao Chang , Vibhor Mishra , Shilpa Narina , Melvin Thomas , Allister J Loughran , Ravi Kalathur , Kaiwen Yu , Suiping Zhou , Xusheng Wang , Anthony A High , Junmin Peng , Shondra M Pruett-Miller , Danette L Daniels , Marjeta Urh , Anang A Shelat , Charles G Mullighan , Kristin M Riching , Guido J R Zaman , Marcus Fischer , Jeffery M Klco , Zoran Rankovic

Journal: Nat Commun

PubMed ID: 38228616

Doi: 10.1038/s41467-024-44698-1

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Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Authors: Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang , Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao

Journal: Nature

PubMed ID: 37993710

Doi: 10.1038/s41586-023-06753-7

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Structural basis of Gabija anti-phage defence and viral immune evasion

Authors: Sadie P Antine, Alex G Johnson, Sarah E Mooney, Azita Leavitt, Megan L Mayer, Erez Yirmiya, Gil Amitai, Rotem Sorek, Philip J Kranzusch

Journal: Nature

PubMed ID: 37992757

Doi: 10.1038/s41586-023-06855-2

Products & Services: Gene Synthesis

A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover

Authors: David S Glass 1, Anat Bren 2, Elizabeth Vaisbourd 2, Avi Mayo 2, Uri Alon

Journal: Cell

PubMed ID: 38320549

Doi: 10.1016/j.cell.2024.01.024

Products & Services: Plasmid DNA Preparation

Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis

Authors: Kai Lu , Xinlong Li , Jie Wu

Journal: Immunity

PubMed ID: 38270316

Doi: 10.1002/iid3.1135

Products & Services: Custom DNA/RNA Oligos

Molecular Atlas of HER2+ Breast Cancer Cells Treated with Endogenous Ligands: Temporal Insights into Mechanisms of Trastuzumab Resistance

Authors: Kavitha Mukund, Jackelyn A Alva-Ornelas, Adam L Maddox, Divya Murali, Darya Veraksa, Andras Saftics, Jerneja Tomsic, David Frankhouser, Meagan Razo, Tijana Jovanovic-Talisman, Victoria L Seewaldt, Shankar Subramaniam

Journal: Cancers (Basel)

PubMed ID: 38339304

Doi: 10.3390/cancers16030553

Products & Services: Recombinant Proteins

Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44

Authors: Emily M Cross, Oriano Marin, Daryl Ariawan, David Aragão, Giorgio Cozza, Enzo Di Iorio, Jade K Forwood, Gualtiero Alvisi

Journal: FEBS Lett

PubMed ID: 38158756

Doi: 10.1002/1873-3468.14797

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Myosin Va-dependent Transport of NMDA Receptors in Hippocampal Neurons

Authors: Ru Gong, Linwei Qin, Linlin Chen, Ning Wang, Yifei Bao, Wei Lu

Journal: Neurosci Bull

PubMed ID: 38291290

Doi: 10.1007/s12264-023-01174-y

Products & Services: Proteins, Expression, Isolation and Analysis

Revamped mini-αA-crystallin showed improved skin permeation and therapeutic activity against melittin-induced toxicity

Authors: Tenzin Tender, Rakesh Ravishankar Rahangdale, Madhavan Nampoothiri, Ruchira Raychaudhuri, Srinivas Mutalik, Krishna Sharma, Raghu Chandrashekar H

Journal: Toxicon

PubMed ID: 38211805

Doi: 10.1016/j.toxicon.2024.107611

Products & Services: Gene Synthesis

Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors

Authors: Chih-Wei Chu, Tomislav Čaval, Frederico Alisson-Silva, Akshaya Tankasala, Christina Guerrier, Gregg Czerwieniec, Heinz Läubli, Flavio Schwarz

Journal: Life Sci Alliance

PubMed ID: 38176728

Doi: 10.26508/lsa.202302368

Products & Services: Mutant Libraries

Development of Moloney Murine Leukemia Virus Reverse Transcriptase Fused with Archaeal DNA-binding Protein Sis7a

Authors: Goldyna M Simanjuntak, Azzania Fibriani, Amalia A Fananda, Nicholas Yamahoki

Journal: Recent Pat Biotechnol

PubMed ID: 37016518

Doi: 10.2174/1872208317666230403104302

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IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway

Authors: Weifeng Xu, Rui Chao, Xinru Xie, Yi Mao, Xinwei Chen, Xuzhuo Chen, Shanyong Zhang

Journal: Cell Commun Signal

PubMed ID: 38291404

Doi: 10.1186/s12964-023-01423-7

Products & Services: Proteins, Expression, Isolation and Analysis

Inactivation mechanism of cold plasma combined with 222 nm ultraviolet for spike protein and its application in disinfecting of SARS-CoV-2

Authors: Xiaowei Sheng, Jin Wang, Luling Zhao, Wenjing Yan, Jing Qian, Zhaobin Wang, Jianhao Zhang, Vijaya Raghavan

Journal: J Hazard Mater

PubMed ID: 38215522

Doi: 10.1016/j.jhazmat.2024.133458

Products & Services: Molecular Biology Reagents

Biosynthesis of 10-Hydroxy-2-decenoic Acid through a One-Step Whole-Cell Catalysis

Authors: Ke Fang , Ziting Xu , Lu Yang , Quan Cui , Bowen Du , Huijing Liu , Ruiming Wang , Piwu Li , Jing Su , Junqing Wang

Journal: J Agric Food Chem .

PubMed ID: 38175798

Doi: 10.1021/acs.jafc.3c08142

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Let-7a-5p Regulates Animal Lipid Accumulation by Targeting Srebf2 and Thbs1 Signaling

Authors: Jiahao Shao , Genglong Jiang , Yanhong Li, Meigui Wang, Tao Tang, Jie Wang , Xianbo Jia and Songjia Lai

Journal: Int. J. Mol. Sci

Doi: 10.3390/ijms25020894

Products & Services: Proteins, Expression, Isolation and Analysis

Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity

Authors: Susan X N Lin, Philip K Ahring, Angelo Keramidas, Vivian W Y Liao, Rikke S Møller, Mary Chebib, Nathan L Absalom

Journal: Brain

PubMed ID: 37647766

Doi: 10.1093/brain/awad285

Products & Services: Plasmid DNA Preparation

PIEZO1 loss-of-function compound heterozygous mutations in the rare congenital human disorder Prune Belly Syndrome

Authors: Nathalia G Amado , Elena D Nosyreva , David Thompson , Thomas J Egeland , Osita W Ogujiofor , Michelle Yang , Alexandria N Fusco , Niccolo Passoni , Jeremy Mathews , Brandi Cantarel , Linda A Baker , Ruhma Syeda

Journal: Nat Commun

PubMed ID: 38184690

Doi: 10.1038/s41467-023-44594-0

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A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

Authors: Gregory H Bird , J J Patten , William Zavadoski , Nicole Barucci , Marina Godes , Benjamin M Moyer , Callum D Owen , Paul DaSilva-Jardine , Donna S Neuberg , Richard A Bowen , Robert A Davey , Loren D Walensky

Journal: Nat Commun

PubMed ID: 38177138

Doi: 10.1038/s41467-023-44361-1

Products & Services: Plasmid DNA Preparation

Massively parallel profiling of RNA-targeting CRISPR-Cas13d

Authors: Hung-Che Kuo , Joshua Prupes , Chia-Wei Chou , Ilya J Finkelstein

Journal: Nat Commun

PubMed ID: 37034598

Doi: 10.1101/2023.03.27.534188

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9S1R nullomer peptide induces mitochondrial pathology, metabolic suppression, and enhanced immune cell infiltration, in triple-negative breast cancer mouse model

Authors: Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R Veerabhadraiah, Laura Bond, Matthew W Turner, Cheryl L Jorcyk, Greg Hampikian

Journal: Biomed Pharmacother

PubMed ID: 38118350

Doi: 10.1016/j.biopha.2023.115997.

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Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α

Authors: Zuen Ren, Malindrie Dharmaratne, Huizhi Liang, Outhiriaradjou Benard, Miriam Morales-Gallego, Kimita Suyama, Viney Kumar, Atefeh Taherian Fard, Ameya S Kulkarni, Michael Prystowsky, Jessica C Mar, Larry Norton, Rachel B Hazan

Journal: Br J Cancer

PubMed ID: 38238426

Doi: 10.1038/s41416-023-02522-5

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Surface-modified measles vaccines encoding oligomeric, prefusion-stabilized SARS-CoV-2 spike glycoproteins boost neutralizing antibody responses to Omicron and historical variants, independent of measles seropositivity

Authors: Miguel Á Muñoz-Alía, Rebecca A Nace, Baskar Balakrishnan, Lianwen Zhang, Nandakumar Packiriswamy, Gagandeep Singh, Prajakta Warang, Ignacio Mena, Riya Narjari, Rianna Vandergaast, Kah-Whye Peng, Adolfo García-Sastre, Michael Schotsaert, Stephen J Russell

Journal: MBio

PubMed ID: 38193729

Doi: 10.1128/mbio.02928-23

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An immunocytokine consisting of a TNFR2 agonist and TNFR2 scFv enhances the expansion of regulatory T cells through TNFR2 clustering

Authors: Masaki Inoue, Yuta Tsuji, Ayaka Kashiwada, Asahi Yokoyama, Akane Iwata, Yasuhiro Abe, Haruhiko Kamada, Shin-Ichi Tsunoda

Journal: Biochem Biophys Res Commun

PubMed ID: 38262291

Doi: 10.1016/j.bbrc.2024.149498

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Production of recombinant HPV11/16 E6/E7-MBP-His fusion proteins and their potential to induce cytokine secretion by immune cells in peripheral blood

Authors: Mei-Nian Xu, Mei-Zhen Zhong, Si-Ning Feng, Yan-Qin Xu, Xiao-Ming Peng, Kang Zeng, Xiao-Wen Huang

Journal: Virol J

PubMed ID: 38183109

Doi: 10.1186/s12985-023-02281-y

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DOCK4 is a Novel Prognostic Biomarker and Correlated with Immune Infiltrates in Colon Adenocarcinoma

Authors: Xingjiang Xie, Yi Lu, Bo Wang, Xiaobin Yin, Jianfeng Chen

Journal: Comb Chem High Throughput Screen

PubMed ID: 37702239

Doi: 10.2174/1386207326666230912094101

Products & Services: Proteins, Expression, Isolation and Analysis

Cross-species immunoprotective antigens (subolesin, ferritin 2 and P0) provide protection against Rhipicephalus sanguineus sensu lato

Authors: Ismail Zeb, Luís Fernando Parizi, Muhammad Israr, Itabajara da Silva Vaz, Abid Ali

Journal: Parasit Vectors

PubMed ID: 38172894

Doi: 10.1186/s13071-023-06079-3

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Nanobodies as potential tools for microbiological testing of live biotherapeutic products

Authors: Robert J Dorosky, Jeremy E Schreier, Stephanie L Lola, Rosa L Sava, Michael P Coryell, Adovi Akue, Mark KuKuruga, Paul E Carlson, Sheila M Dreher-Lesnick, Scott Stibitz

Journal: AMB Express

PubMed ID: 38245586

Doi: 10.1186/s13568-023-01659-z

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Oral delivery of bacteria expressing wsv108 gene-specific dsRNA protects shrimp from white spot syndrome virus (WSSV) infection

Authors: Linwei Yang, Siyou Huang, Zi-Ang Wang, Deyu Han, Yushi Gan, Ran Geng, Hongliang Zuo, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu

Journal: Int J Biol Macromol

PubMed ID: 38302014

Doi: 10.1016/j.ijbiomac.2024.129840

Products & Services: Proteins, Expression, Isolation and Analysis

Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase

Authors: Marlo K Thompson, Nidhi Sharma, Andrea Thorn, Aishwarya Prakash

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 38289715

Doi: 10.1107/S205979832400038X

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Longitudinal analysis of antibody responses to Plasmodium vivax sporozoite antigens following natural infection

Authors: Pongsakorn Thawornpan, Justin Nicholas, Chayapat Malee, Piyawan Kochayoo, Kittikorn Wangriatisak, Pachara Tianpothong, Francis Babila Ntumngia, Samantha J Barnes, John H Adams, Patchanee Chootong

Journal: PLoS Negl Trop Dis

PubMed ID: 38277340

Doi: 10.1371/journal.pntd.0011907

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Identification and Functional Characterization of Oxidosqualene Cyclases from Medicinal Plant

Authors: Iffat Parveen, Mei Wang, Joseph Lee, Jianping Zhao, Yingjie Zhu, Amar G Chittiboyina, Ikhlas A Khan, Zhiqiang Pan

Journal: Plants (Basel)

PubMed ID: 38256784

Doi: 10.3390/plants13020231

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A dual-functional oncolytic adenovirus ZD55-aPD-L1 scFv armed with PD-L1 inhibitor potentiates its antitumor activity

Authors: Shengsheng Mei, Shanshan Peng, Eu Gene Vong, Jinbiao Zhan

Journal: Int Immunopharmacol

PubMed ID: 38278066

Doi: 10.1016/j.intimp.2024.111579

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Mulberry-derived miR168a downregulates BmMthl1 to promote physical development and fecundity in silkworms

Authors: Lin Chen, Jiubo Liang, Qi Zhang, Chao Yang, Hulin Lu, Renze Zhang, Kaiying Chen, Sheng Wang, Mingbo Li, Shaoyu Zhang, Ningjia He

Journal: Int J Biol Macromol

PubMed ID: 38199542

Doi: 10.1016/j.ijbiomac.2023.129077

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A novel fully human anti-NT-ANGPTL3 antibody from phage display library exhibits potent ApoB, TG, and LDL-C lowering activities in hyperlipidemia mice

Authors: Panpan Zhang, Ke Wang, Tuo Hu, Menglong Xu, Xiangyan You, Manman Chen, Xuan Tang, Huajing Hu, Yiwei Jiang, Wenfeng Zhao, Shuhua Tan

Journal: FASEB J

PubMed ID: 38174870

Doi: 10.1096/fj.202301564RR

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Individual transmembrane domains of SfABCC2 from Spodoptera frugiperda do not serve as functional Cry1F receptors

Authors: Jianfeng Zhong, Rafael Ferreira Dos Santos, Heba Abdelgaffar, Caroline Placidi de Bortoli, Ahmad Raza, Juan Luis Jurat-Fuentes

Journal: Pestic Biochem Physiol

PubMed ID: 38458684

Doi: 10.1016/j.pestbp.2024.105777

Products & Services: Proteins, Expression, Isolation and Analysis

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Authors: Yehudi Bloch, Jan Felix, Romain Merceron, Mathias Provost, Royan Alipour Symakani, Robin De Backer, Elisabeth Lambert, Ahmad R Mehdipour, Savvas N Savvides

Journal: Nat Struct Mol Biol

PubMed ID: 38287195

Doi: 10.1038/s41594-023-01190-6

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Temporal dynamics of the early immune response following Mycobacterium bovis infection of cattle

Authors: Thomas Holder, Sreenidhi Srinivasan, Adrian McGoldrick, Gareth A Williams, Simonette Palmer, John Clarke, Amanda O'Brien, Andrew J K Conlan, Nick Juleff, H Martin Vordermeier, Gareth J Jones, Vivek Kapur

Journal: Sci Rep

PubMed ID: 38297023

Doi: 10.1038/s41598-024-52314-x

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Multivalent Calixarene Complexation of a Designed Pentameric Lectin

Authors: Ronan J Flood, Linda Cerofolini, Marco Fragai, Peter B Crowley

Journal: Biomacromolecules

PubMed ID: 38227741

Doi: 10.1021/acs.biomac.3c01280

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Design of protein-binding peptides with controlled binding affinity: the case of SARS-CoV-2 receptor binding domain and angiotensin-converting enzyme 2 derived peptides

Authors: Giacomo Parisi, Roberta Piacentini, Alessio Incocciati, Alessandra Bonamore, Alberto Macone, Jakob Rupert, Elsa Zacco, Mattia Miotto, Edoardo Milanetti, Gian Gaetano Tartaglia, Giancarlo Ruocco, Alberto Boffi, Lorenzo Di Rienzo

Journal: Front Mol Biosci

PubMed ID: 38250735

Doi: 10.3389/fmolb.2023.1332359

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Proteome profiling of enriched membrane-associated proteins unraveled a novel sophorose and cello-oligosaccharide transporter in Trichoderma reesei

Authors: Karoline Maria Vieira Nogueira, Vanessa Mendes, Karthik Shantharam Kamath, Anusha Cheruku, Letícia Harumi Oshiquiri, Renato Graciano de Paula, Claudia Carraro, Wellington Ramos Pedersoli, Lucas Matheus Soares Pereira, Luiz Carlos Vieira, Andrei Stecca Steindorff, Ardeshir Amirkhani, Matthew J McKay, Helena Nevalainen, Mark P Molloy, Roberto N Silva

Journal: Microb Cell Fact

PubMed ID: 38229067

Doi: 10.1186/s12934-023-02279-9

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Improved Solubility and Stability of a Thermostable Carbonic Anhydrase via Fusion with Marine-Derived Intrinsically Disordered Solubility Enhancers

Authors:

Journal: Int J Mol Sci

PubMed ID: 38256209

Doi: 10.3390/ijms25021139

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ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis

Authors: Shen Li, Jiangbo Han, Jiongzhe Cao, Hong Han, Bin Lu, Tao Wen, Weiguo Bian

Journal: Environ Toxicol

PubMed ID: 38174997

Doi: 10.1002/tox.24131

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High-titer manufacturing of SARS-CoV-2 Spike-pseudotyped VSV in stirred-tank bioreactors

Authors: Hayley M Todesco, Chris Gafuik, Cini M John, Erin L Roberts, Breanna S Borys, Alexis Pawluk, Michael S Kallos, Kyle G Potts, Douglas J Mahoney

Journal: Mol Ther Methods Clin Dev

PubMed ID: 38327804

Doi: 10.1016/j.omtm.2024.101189

Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome

Authors: Nanyang Liu, Yanqiu Ding, Hao Zhou, Xing Chang, Long Lou

Journal: Int J Med Sci

PubMed ID: 38322592

Doi: 10.7150/ijms.90484

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted mutagenesis in mice via an engineered AsCas12f1 system

Authors: Peng Fan, Hejun Wang, Feiyu Zhao, Tao Zhang, Jinze Li, Xiaodi Sun, Yongduo Yu, Haoyang Xiong, Liangxue Lai, Tingting Sui

Journal: Cell Mol Life Sci

PubMed ID: 38280977

Doi: 10.1007/s00018-023-05100-3

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TLR4 Ligands in Typhoid Vi Polysaccharide Subunit Vaccines Contribute to Immunogenicity

Authors:

Journal: Immunohorizons

PubMed ID: 38180344

Doi: 10.4049/immunohorizons.2300085

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A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells

Authors: Shivakshi Sulekh, Yuko Ikegawa, Saki Naito, Asami Oji, Ichiro Hiratani, Sa Kan Yoo

Journal: Life Sci Alliance

PubMed ID: 38296349

Doi: 10.26508/lsa.202302238

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Clinical assays rapidly predict bacterial susceptibility to monoclonal antibody therapy

Authors: Matthew J Slarve, Neven Bowler, Elizabeth Burk, Jun Yan, Ulrike Carlino-MacDonald, Thomas A Russo, Brian M Luna, Brad Spellberg

Journal: JCI Insight

PubMed ID: 38258902

Doi: 10.1172/jci.insight.174799

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B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure

Authors: Yuting Zhai, Junhong Chen, Rongsheng Kan, Haochen Xuan, Chaofan Wang, Dongye Li, Tongda Xu

Journal: Int Heart J

PubMed ID: 38556337

Doi: 10.1536/ihj.23-144

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Recombinant protein expression in proteome-reduced cells under aerobic and oxygen-limited regimes

Authors: Alvaro R Lara, Jose Utrilla, Luz María Martínez, Niels Krausch, Lucas Kaspersetz, David Hidalgo, Nicolas Cruz-Bournazou, Peter Neubauer, Juan-Carlos Sigala, Guillermo Gosset, Jochen Büchs

Journal: Biotechnol Bioeng

PubMed ID: 38178599

Doi: 10.1002/bit.28645

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Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif

Authors: Wuyang Shi , Shibo Sun , Haowen Liu , Yao Meng , Kangshuai Ren , Guoying Wang , Minghui Liu , Jiaqi Wu , Yue Zhang , Huang Huang , Meiyun Shi , Weiping Xu , Qiang Ma , Bingbing Sun , Jianqiang Xu

Journal: Redox biology

Doi: 10.1016/j.redox.2024.103050

Products & Services: Proteins, Expression, Isolation and Analysis

Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules

Authors: Christopher M. Hickey, Katherine M. Digianantonio, Kurt Zimmermann , Alicia Harbin, Connor Quinn, Avani Patel, Peter Gareiss , Amanda Chapman1 , Bernadette Tiberi1,2, Jennifer Dobrodziej1,3, John Corradi1 , Angela M. Cacace1 , David R. Langley & Miklós Békés

Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY

Doi: 10.1038/s41594-023-01146-w

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Influenza a Neuraminidase-Based Bivalent mRNA Vaccine Induces Th1-Type Immune Response and Provides Protective Effects in Mice

Authors: Mingyang Li , Mengyuan Liu , Shaohui Song, Ruirui Zhao, Yun Xie, Jing Liu, Lilan Xu, Xuefeng Ma, Mingyu Song, Jian Zhou and Guoyang Liao

Journal: vaccine

Doi: 10.3390/vaccines12030300

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The structure of the diheme cytochrome c from Neisseria gonorrhoeae reveals multiple contributors to tuning reduction potentials

Authors: Fangfang Zhong, Morgan E Reik, Michael J Ragusa, Ekaterina V Pletneva

Journal: J Inorg Biochem

PubMed ID: 38330683

Doi: 10.1016/j.jinorgbio.2024.112496

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Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2

Authors: Klara Lenart, Rodrigo Arcoverde Cerveira, Fredrika Hellgren, Sebastian Ols, Daniel J Sheward, Changil Kim, Alberto Cagigi, Matthew Gagne, Brandon Davis, Daritza Germosen, Vicky Roy, Galit Alter, Hélène Letscher, Jérôme Van Wassenhove, Wesley Gros, Anne-Sophie Gallouët, Roger Le Grand, Harry Kleanthous, Mimi Guebre-Xabier, Ben Murrell, Nita Patel, Gregory Glenn, Gale Smith, Karin Loré

Journal: npj Vaccines

PubMed ID: 38245545

Doi: 10.1038/s41541-024-00806-2

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Systematic analysis of the prognostic value and immunological function of LTBR in human cancer

Authors: Yinteng Wu, Shijian Zhao, Wenliang Guo, Ying Liu, Marìa Del Mar Requena Mullor, Raquel Alarcòn Rodrìguez, Ruqiong Wei

Journal: Aging (Albany NY)

PubMed ID: 38175686

Doi: 10.18632/aging.205356

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A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction

Authors: Sibei Tang, Junxun Zhang, Fangzhou Lou, Hong Zhou, Xiaojie Cai, Zhikai Wang, Libo Sun, Yang Sun, Xiangxiao Li, Li Fan, Yan Li, Xinping Jin, Siyu Deng, Qianqian Yin, Jing Bai, Hong Wang, Honglin Wang

Journal: EMBO Rep

PubMed ID: 38291338

Doi: 10.1038/s44319-024-00070-4

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Complete microbial synthesis of crocetin and crocins from glycerol in Escherichia coli

Authors: Jun Ho Lee, Seong-Rae Lee, Sang Yup Lee, Pyung Cheon Lee

Journal: Microb Cell Fact

PubMed ID: 38178149

Doi: 10.1186/s12934-023-02287-9

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Structural and functional properties of uridine 5'-monophosphate synthase from Coffea arabica

Authors: Alexis Hinojosa-Cruz, Ángel G Díaz-Sánchez, Adelaida Díaz-Vilchis, Lilian González-Segura

Journal: Int J Biol Macromol

PubMed ID: 38184030

Doi: 10.1016/j.ijbiomac.2024.129226

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Circ_0007422 Knockdown Inhibits Tumor Property and Immune Escape of Colorectal Cancer by Decreasing PDL1 Expression in a miR-1256-Dependent Manner

Authors: Dian Yin, Li Yang, Xiu Feng, Xiaolu Zhai, Mei Hua, Jing Liu, Ying Chen

Journal: Mol Biotechnol

PubMed ID: 38253900

Doi: 10.1007/s12033-023-01040-2

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Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury

Authors: Ari Kwon, Na Young Lee, Jae-Hyun Yu, Myeung Gi Choi, Jeongwoo Park, Ja Hyun Koo

Journal: Cell Death Dis

PubMed ID: 38225223

Doi: 10.1038/s41419-024-06448-5

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PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Authors: Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Michael L Nosella, Hongshan Zhang, T Reid Alderson, Morgan Dasovich, Anthony Leung, Ilya J Finkelstein, Julie D Forman-Kay, Hyun O Lee

Journal: biorxiv

PubMed ID: 38328070

Doi: 10.1101/2024.01.20.575817

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CFL1 restores the migratory capacity of bone marrow mesenchymal stem cells in primary Sjögren's syndrome by regulating CCR1 expression

Authors: Mengxi Huang, Panpan Zhou, Yang Hang, Dan Wu, Nan Zhao, Genhong Yao, Xiaojun Tang, Lingyun Sun

Journal: Int Immunopharmacol

PubMed ID: 38183912

Doi: 10.1016/j.intimp.2024.111485

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A novel opsonic eCIRP inhibitor for lethal sepsis

Authors: Colleen P Nofi, Chuyi Tan, Gaifeng Ma, Molly Kobritz, Jose M Prince, Haichao Wang, Monowar Aziz, Ping Wang

Journal: J Leukoc Biol

PubMed ID: 37774691

Doi: 10.1093/jleuko/qiad119

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Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production

Authors: Sri Harsha Adusumilli, Anuthariq Alikkam Veetil, Chinmayee Choudhury, Banani Chattopadhyaya, Diptimayee Behera, Anand Kumar Bachhawat

Journal: FEBS Open Bio

PubMed ID: 38124687

Doi: 10.1002/2211-5463.13755

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The CRISPR effector Cam1 mediates membrane depolarization for phage defence

Authors: Christian F. Baca, You Yu, Jakob T. Rostøl, Puja Majumder, Dinshaw J. Patel & Luciano A. Marraffini

Journal: Nature

PubMed ID: 38200316

Doi: 10.1038/s41586-023-06902-y

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Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

Authors: Jun Wang , Jinyong Huang , Yunlong Hu , Qianwen Guo , Shasha Zhang , Jinglin Tian , Yanqin Niu , Ling Ji , Yuzhong Xu , Peijun Tang , Yaqin He , Yuna Wang , Shuya Zhang , Hao Yang , Kang Kang , Xinchun Chen , Xinying Li , Ming Yang , Deming Gou

Journal: Nat Commun

PubMed ID: 38168054

Doi: 10.1038/s41467-023-44461-y

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Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1-Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

Authors: Andrew V Oleinikov, Zakaria Seidu, Irina V Oleinikov, Mary Tetteh, Helena Lamptey, Michael F Ofori, Lars Hviid, Mary Lopez-Perez

Journal: J Infect Dis

PubMed ID: 37804095

Doi: 10.1093/infdis/jiad438

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Cdk5-dependent rapid formation and stabilization of dendritic spines by corticotropin-releasing factor

Authors: Dorien Vandael, Katlijn Vints, Pieter Baatsen, Małgorzata A Śliwińska, Sergio Gabarre, Lies De Groef, Lieve Moons, Vasily Rybakin, Natalia V Gounko

Journal: Transl Psychiatry

PubMed ID: 38233378

Doi: 10.1038/s41398-024-02749-7

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Authors: Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza

Journal: Pharmaceutics

PubMed ID: 38258126

Doi: 10.3390/pharmaceutics16010116

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Restricted Omicron-specific cross-variant memory B-cell immunity after a 3rd dose/booster of monovalent Wuhan-Hu-1-containing COVID-19 mRNA vaccine

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Nathaniel D Warner, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: Vaccine

PubMed ID: 38233288

Doi: 10.1016/j.vaccine.2024.01.032

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Phylogenetic conservation of Trop-2 across species-rodent and primate genomics model anti-Trop-2 therapy for pre-clinical benchmarks

Authors: Emanuela Guerra, Marco Trerotola, Valeria Relli, Rossano Lattanzio, Khouloud Boujnah, Nicole Travali, Antonino Moschella, Paolo Todaro, Laura Pierdomenico, Roberta Di Pietro, Nicola Tinari, Saverio Alberti

Journal: Front Genet

PubMed ID: 38250577

Doi: 10.3389/fgene.2023.1297367

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Construction and characterization of a humanized rat model with its application in evaluating the uptake of different statins

Authors: Yuanjin Zhang, Junze Huang, Shengbo Huang, Jie Liu, Luyao Deng, Chenmeizi Liang, Yuanqing Guo, Bingyi Yao, Xin Wang

Journal: Acta Pharm Sin B

PubMed ID: 38572097

Doi: 10.1016/j.apsb.2023.12.019

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LINC00662 promotes melanoma progression by competitively binding miR-107 and activating the β-catenin signaling pathway

Authors: Mengmeng Luo, Rui Lei, Qingfang Zhao, Yichen Shen, Zhigang He, Jinghong Xu

Journal: Int J Med Sci

PubMed ID: 38169586

Doi: 10.7150/ijms.84072

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Precise coordination between nutrient transporters ensures fertility in the malaria mosquito Anopheles gambiae

Authors: Iryna Stryapunina, Maurice A Itoe, Queenie Trinh, Charles Vidoudez, Esrah Du, Lydia Mendoza, Oleksandr Hulai, Jamie Kauffman, John Carew, W Robert Shaw, Flaminia Catteruccia

Journal: PLoS Genet

PubMed ID: 38285728

Doi: 10.1371/journal.pgen.1011145

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Delivery of mRNA with Histidine-Lysine Peptides

Authors: Qixin Leng, Jiaxi He, Aishwarya Anand, A James Mixson

Journal: Methods Mol Biol

PubMed ID: 38907929

Doi: 10.1007/978-1-0716-3918-4_23

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Leafhopper salivary vitellogenin mediates virus transmission to plant phloem

Authors: Yanfei Wang , Chengcong Lu , Shude Guo , Yuxin Guo , Taiyun Wei , Qian Chen

Journal: Nat Commun

PubMed ID: 38167823

Doi: 10.1038/s41467-023-43488-5

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