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Structural Determinants of FeoB Nucleotide Promiscuity

Authors: Mark Lee, Kate Magante, Camilo Gómez-Garzón, Shelley M Payne, Aaron T Smith

Journal: biorxiv

PubMed ID: 38826458

Doi: 10.1101/2024.05.22.595361

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SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress

Authors: Shuaiyang Jing, Jingkai Gao, Neeraj Tiwari, Yulei Du, Lianhui Zhu, Bopil Gim, Yi Qian, Xihua Yue, Intaek Lee

Journal: Commun Biol

PubMed ID: 38710927

Doi: 10.1038/s42003-024-06232-3

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Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease

Authors: Emelie E Aspholm, Jens Lidman, Björn M Burmann

Journal: Nat Commun

PubMed ID: 38816423

Doi: 10.1038/s41467-024-48997-5

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A new suite of reporter vectors and a novel landing site survey system to study cis-regulatory elements in diverse insect species

Authors: Kevin D Deem, Marc S Halfon, Yoshinori Tomoyasu

Journal: Sci Rep

PubMed ID: 38698030

Doi: 10.1038/s41598-024-60432-9

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Identification of an Immunodominant B-Cell Epitope in African Swine Fever Virus p30 Protein and Evidence of p30 Antibody-Mediated Antibody Dependent Cellular Cytotoxicity

Authors: Jessica C G Noll, Ruchi Rani, Salman L Butt, Maureen Hoch Vieira Fernandes, Gabriela Mansano do Nascimento, Mathias Martins, Leonardo C Caserta, Lina Covaleda, Diego G Diel

Journal: Viruses

PubMed ID: 38793639

Doi: 10.3390/v16050758

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Discrimination of Aspartic and Isoaspartic Acid Residues in Peptides by Tandem Mass Spectrometry with Hydrogen Attachment Dissociation

Authors: Daiki Asakawa, Shinich Iwamoto, Koichi Tanaka

Journal: Anal Chem

PubMed ID: 38741470

Doi: 10.1021/acs.analchem.4c00561

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SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

Authors: Ze-Zheng Jiang, Min Chu, Li-Na Yan, Wen-Kang Zhang, Bang Li, Jiao Xu, Zhong-Xin Zhao, Hui-Ju Han, Chuan-Min Zhou, Xue-Jie Yu

Journal: Microbiol Spectr

PubMed ID: 38712963

Doi: 10.1128/spectrum.03796-23

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Functional Characterization of F3H Gene and Optimization of Dihydrokaempferol Biosynthesis in

Authors: Qinyi Chen, Dandan Song, Xiaoyan Sun, Yulong Tian, Zecheng Yan, Ting Min, Hongxun Wang, Limei Wang

Journal: Molecules

PubMed ID: 38792058

Doi: 10.3390/molecules29102196

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Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury

Authors: Yuhao Xu, Limoran Tang, Chao Zhou, Liang Sun, Yujie Hu, Zhi Zhang, Shengnan Xia, Xinyu Bao, Haiyan Yang, Yun Xu

Journal: CNS Neurosci Ther

PubMed ID: 38715283

Doi: 10.1111/cns.14742

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YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway

Authors: Yue Shi, Yue Cheng, Wei Wang, Liu Tang, Wensheng Li, Liyuan Zhang, Zheng Yuan, Feng Zhu, Qiuhong Duan

Journal: Sci Rep

PubMed ID: 38714727

Doi: 10.1038/s41598-024-61157-5

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Identification of a Fully Human Antibody VH Domain Targeting Anaplastic Lymphoma Kinase (ALK) with Applications in ALK-Positive Solid Tumor Immunotherapy

Authors: Chuan Chen, Zehua Sun, Zening Wang, Seungmin Shin, Abigail Berrios, John W Mellors, Dimiter S Dimitrov, Wei Li

Journal: Antibodies (Basel)

PubMed ID: 38804307

Doi: 10.3390/antib13020039

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Functional Analysis of the Major Pilin Proteins of Type IV Pili in CGMH010

Authors: Yi-Ywan M Chen, Yuan-Chen Yang, Hui-Ru Shieh, Yu-Juan Lin, Wan-Ju Ke, Cheng-Hsun Chiu

Journal: Int J Mol Sci

PubMed ID: 38791440

Doi: 10.3390/ijms25105402

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Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies

Authors: Roman R Schlimgen, Francis C Peterson, Raimond Heukers, Martine J Smit, John D McCorvy, Brian F Volkman

Journal: Nat Commun

PubMed ID: 38816420

Doi: 10.1038/s41467-024-49000-x

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Tardigrade secretory proteins protect biological structures from desiccation

Authors: Samuel Lim, Charles B Reilly, Zeina Barghouti, Benedetto Marelli, Jeffrey C Way, Pamela A Silver

Journal: Commun Biol

PubMed ID: 38796644

Doi: 10.1038/s42003-024-06336-w

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MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells

Authors: Yanmiao Dai, Yudong Xu, Jie Shen, Caihong Hu, Xiaoli Li, Yongyu Chen, Yao Liu, Duanmin Hu

Journal: Exp Cell Res

PubMed ID: 38802035

Doi: 10.1016/j.yexcr.2024.114099

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Aβ and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer's disease

Authors: Liding Zhang, Kai Cao, Jun Xie, Xiaohan Liang, Hui Gong, Qingming Luo, Haiming Luo

Journal: J Nanobiotechnology

PubMed ID: 38783363

Doi: 10.1186/s12951-024-02543-z

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The 6-kilodalton peptide 1 in plant viruses of the family Potyviridae is a viroporin

Authors: Mengzhu Chai, Lei Li, Yong Li, Yingshuai Yang, Yuting Wang, Xue Jiang, Yameng Luan, Fangfang Li, Hongguang Cui, Aiming Wang, Wensheng Xiang, Xiaoyun Wu, Xiaofei Cheng

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38739789

Doi: 10.1073/pnas.2401748121

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Bazi Bushen alleviates reproductive aging in aged male mice

Authors: Kun Ma, Mengnan Li, Yahui Song, Xinjing Mao, Shaolan Zhang, Yaping Zhang, Yuning Jiang, Chuanyuan Ji, Kunxu Niu, Hongrong Li, Yunlong Hou, Cong Wei

Journal: Chin J Nat Med

PubMed ID: 38796215

Doi: 10.1016/S1875-5364(24)60639-4

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Virus-like particle-based multipathogen vaccine of FMD and SVA elicits balanced and broad protective efficacy in mice and pigs

Authors: Hetao Song, Sahibzada Waheed Abdullah, Shuanghui Yin, Hu Dong, Yun Zhang, Shuzhen Tan, Manyuan Bai, Yaozhong Ding, Zhidong Teng, Shiqi Sun, Huichen Guo

Journal: Vaccine

PubMed ID: 38714448

Doi: 10.1016/j.vaccine.2024.04.092

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POLR2J expression promotes glioblastoma malignancy by regulating oxidative stress and the STAT3 signaling pathway

Authors: Xiao-Li Zheng, Zhi-Di Li, Kai-Zhi Luo, Yang-Ling Li, Ye-Han Liu, Shu-Ying Shen, Fei-Yan Shen, Wan-Yan Li, Guo-Qing Chen, Chong Zhang, Ling-Hui Zeng

Journal: Am J Cancer Res

PubMed ID: 38859843

Doi: 10.62347/JEWM7691

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Functional characterization of the InR/PI3K/AKT signaling pathway in female reproduction of the predatory bug Cyrtorhinus lividipennis (Hemiptera: Miridae)

Authors: Kui Hu, Rong Jin, Jianqi Liu, Jun Zhu, Wei Dai, Ying Wang, Yao Li, Fang Liu

Journal: J Econ Entomol

PubMed ID: 38783398

Doi: 10.1093/jee/toae113

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Alpha and gamma mangostins inhibit wild-type B SARS-CoV-2 more effectively than the SARS-CoV-2 variants and the major target is unlikely the 3C-like protease

Authors: Aphinya Suroengrit, Van Cao, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Kowit Hengphasatporn, Ryuhei Harada, Supakarn Chamni, Asada Leelahavanichkul, Yasuteru Shigeta, Thanyada Rungrotmongkol, Supot Hannongbua, Warinthorn Chavasiri, Supaporn Wacharapluesadee, Eakachai Prompetchara, Siwaporn Boonyasuppayakorn

Journal: Heliyon

PubMed ID: 38867992

Doi: 10.1016/j.heliyon.2024.e31987

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Discovery of UMI-77 as a novel Ku70/80 inhibitor sensitizing cancer cells to DNA damaging agents in vitro and in vivo

Authors: Xuening Chen, Changkun Chen, Chengmiao Luo, Jianyong Liu, Zhonghui Lin

Journal: Eur J Pharmacol

PubMed ID: 38754534

Doi: 10.1016/j.ejphar.2024.176647

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Staphylococcal peroxidase inhibitor (SPIN): Residue-level investigation of the helical bundle domain

Authors: Soheila Fatehi, Timothy J Herdendorf, Nicoleta T Ploscariu, Brian V Geisbrecht

Journal: Arch Biochem Biophys

PubMed ID: 38705227

Doi: 10.1016/j.abb.2024.110023

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Establishment of an ELISA Based on a Recombinant Antigenic Protein Containing Multiple Prominent Epitopes for Detection of African Swine Fever Virus Antibodies

Authors: Dossêh Jean Apôtre Afayibo, Zhonghui Zhang, Hualin Sun, Jingsheng Fu, Yaru Zhao, Tharheer Oluwashola Amuda, Mengli Wu, Junzheng Du, Guiquan Guan, Qingli Niu, Jifei Yang, Hong Yin

Journal: Microorganisms

PubMed ID: 38792774

Doi: 10.3390/microorganisms12050943

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MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

Authors: Tao Wang, Dan Song, Xuejuan Li, Yu Luo, Dianqiang Yang, Xiaoyan Liu, Xiaodan Kong, Yida Xing, Shulin Bi, Yan Zhang, Tao Hu, Yunyun Zhang, Shuang Dai, Zhiqiang Shao, Dahan Chen, Jinpao Hou, Esteban Ballestar, Jianchun Cai, Feng Zheng, James Y Yang

Journal: Cell Commun Signal

PubMed ID: 38589923

Doi: 10.1186/s12964-024-01601-1

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Mechanistic insights into the alternative ribosome recycling by HflXr

Authors: Savannah M Seely, Ritwika S Basu, Matthieu G Gagnon

Journal: Nucleic Acids Res

PubMed ID: 38407413

Doi: 10.1093/nar/gkae128

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Receptor-recognition and antiviral mechanisms of retrovirus-derived human proteins

Authors: Shashank Khare, Miryam I Villalba, Juan C Canul-Tec, Arantza Balsebre Cajiao, Anand Kumar, Marija Backovic, Felix A Rey, Els Pardon, Jan Steyaert, Camilo Perez, Nicolas Reyes

Journal: Nat Struct Mol Biol

PubMed ID: 38671230

Doi: 10.1038/s41594-024-01295-6

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CDK5-mediated rearrangement of vimentin during Duck Tembusu virus infection inhibits viral replication

Authors: Guangbin Bao, Shinuo Fan, Chunyan Hu, Chen Li, Fei Ma, Guijun Wang, Hongjie Fan, Qing Wang

Journal: Vet Microbiol

PubMed ID: 38574695

Doi: 10.1016/j.vetmic.2024.110071

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Searching for new plastic-degrading enzymes from the plastisphere of alpine soils using a metagenomic mining approach

Authors: Beat Frey, Margherita Aiesi, Basil M Rast, Joel Rüthi, Jérôme Julmi, Beat Stierli, Weihong Qi, Ivano Brunner

Journal: PLoS ONE

PubMed ID: 38578779

Doi: 10.1371/journal.pone.0300503

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The Trimeric Autotransporter Adhesin SadA from spp as a Novel Bacterial Surface Display System

Authors: Shuli Sang, Wenge Song, Lu Lu, Qikun Ou, Yiyan Guan, Haoxia Tao, Yanchun Wang, Chunjie Liu

Journal: Vaccines (Basel)

PubMed ID: 38675781

Doi: 10.3390/vaccines12040399

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Plasmodium RNA triphosphatase validation as antimalarial target

Authors: Sonia Moliner-Cubel, Noemi Bahamontes-Rosa, Ane Rodriguez-Alejandre, Pamela M Nassau, Argyrides Argyrou, Anshu Bhardwaja, Rachel C Buxton, David Calvo-Vicente, Bernadette Mouzon, William McDowell, Alfonso Mendoza-Losana, Maria G Gomez-Lorenzo

Journal: Int J Parasitol Drugs Drug Resist

PubMed ID: 38810336

Doi: 10.1016/j.ijpddr.2024.100537

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microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

Authors: Xinghan Chen, Yueru Shen, Zheng Song, Xinliang Wang, Huaitong Yao, Yuan Cai, Zi-Ang Zhao, Bing Hu

Journal: J Genet Genomics

PubMed ID: 38582297

Doi: 10.1016/j.jgg.2024.03.016

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A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells

Authors: Hema Preethi Subas Satish, Sweta Iyer, Melissa X Shi, Agnes W Wong, Karla C Fischer, Ahmad Z Wardak, Daisy Lio, Jason M Brouwer, Rachel T Uren, Peter E Czabotar, Michelle S Miller, Ruth M Kluck

Journal: Cell Death Differ

PubMed ID: 38582955

Doi: 10.1038/s41418-024-01289-3

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The proteomic analysis uncovers the cellular responses to the African swine fever virus membrane proteins p54, p17, and pB117L

Authors: Yuhong Chen, Jianqiang Ni, Chuanbin Wang, Xinyan Zhai, Tingrong Luo, Yi-Ping Li, Youchuan Wei, Yuliang Liu

Journal: Microbes Infect

PubMed ID: 38697277

Doi: 10.1016/j.micinf.2024.105348

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Interleukin-2 is required for NKp30-dependent NK cell cytotoxicity by preferentially regulating NKp30 expression

Authors: Nayoung Kim, Eunbi Yi, Eunbi Lee, Hyo Jin Park, Hun Sik Kim

Journal: Front Immunol

PubMed ID: 38698855

Doi: 10.3389/fimmu.2024.1388018

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The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype

Authors: Anja Schollmeier, Michael Basic, Mirco Glitscher, Eberhard Hildt

Journal: J Virol

PubMed ID: 38629837

Doi: 10.1128/jvi.00424-24

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Food-Grade Expression of Two Laccases in and Study on Their Enzymatic Degradation Characteristics for Mycotoxins

Authors: Zhen Sun, Yingxin You, Huidong Xu, Yang You, Wenjing He, Zhouping Wang, Aitao Li, Yu Xia

Journal: J Agric Food Chem

PubMed ID: 38600054

Doi: 10.1021/acs.jafc.4c00521

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Efficient activity screening of new glucuronoyl esterases using a pNP-based assay

Authors: Michael S Madsen, Pedro A Martins, Jane W Agger

Journal: Enzyme Microb Technol

PubMed ID: 38581869

Doi: 10.1016/j.enzmictec.2024.110444

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Efficacy of genotype-matched vaccine against re-emerging genotype V Japanese encephalitis virus

Authors: Jae-Deog Kim, Ah-Ra Lee, Dah-Hyun Moon, Young-Uk Chung, Su-Yeon Hong, Hyo Je Cho, Tae Hyun Kang, Yo Han Jang, Myung Hyun Sohn, Baik-Lin Seong, Sang-Uk Seo

Journal: Emerg Microbes Infect

PubMed ID: 38618740

Doi: 10.1080/22221751.2024.2343910

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Remotely controlled drug release in deep brain regions of non-human primates

Authors: Matthew G Wilson, Taylor D Webb, Henrik Odéen, Jan Kubanek

Journal: J Control Release

PubMed ID: 38604386

Doi: 10.1016/j.jconrel.2024.04.013

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Synthesis of site-specific Fab-drug conjugates using ADP-ribosyl cyclases

Authors: Hyo Sun Kim, Kimia Hariri, Xiao-Nan Zhang, Liang-Chieh Chen, Benjamin B Katz, Hua Pei, Stan G Louie, Yong Zhang

Journal: Protein Sci

PubMed ID: 38501590

Doi: 10.1002/pro.4924

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Development of an effective single-chain variable fragment recognizing a novel epitope in the hepatitis C virus E2 protein that restricts virus entry into hepatocytes

Authors: Soma Das, Padmanava Behera, Dipeshwari J Shewale, Janhavi Bodele, Saumitra Das, Anjali A Karande

Journal: Arch Virol

PubMed ID: 38683226

Doi: 10.1007/s00705-024-06024-4

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Broad-spectrum Delta-BA2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex

Authors: Pei Du, Lei Huang, Yi Fang, Fanfan Zhao, Qianyun Li, Xuehui Ma, Ruiqi Li, Qian Chen, Haifa Shen, Qihui Wang, Hangwen Li, George Fu Gao

Journal: PLoS Pathog

PubMed ID: 38557908

Doi: 10.1371/journal.ppat.1012116

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Durlobactam, a Diazabicyclooctane β-Lactamase Inhibitor, Inhibits BlaC and Peptidoglycan Transpeptidases of

Authors: Mary Nantongo, David C Nguyen, Christopher R Bethel, Magdalena A Taracila, Qing Li, Khalid M Dousa, Eunjeong Shin, Sebastian G Kurz, Liem Nguyen, Barry N Kreiswirth, W Henry Boom, Mark S Plummer, Robert A Bonomo

Journal: ACS Infect Dis

PubMed ID: 38619138

Doi: 10.1021/acsinfecdis.4c00119

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An Elastin-Derived Composite Matrix for Enhanced Vascularized and Innervated Bone Tissue Reconstruction: From Material Development to Preclinical Evaluation

Authors: Nadia Mahmoudi, Micaela Roque, Bruno Paiva Dos Santos, Hugo Oliveira, Robin Siadous, Sylvie Rey, Elisabeth Garanger, Sébastien Lecommandoux, Sylvain Catros, Bertrand Garbay, Joëlle Amédée Vilamitjana

Journal: Adv Healthc Mater

PubMed ID: 38651610

Doi: 10.1002/adhm.202303765

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Saccharomyces cerevisiae oral immunization in mice using multi-antigen of the African swine fever virus elicits a robust immune response

Authors: Shuo Gao, Wenfeng Zuo, Chao Kang, Zhong Zou, Kaiqi Zhang, Jun Qiu, Xiaomin Shang, Jingjing Li, Yuanfeng Zhang, Qi Zuo, Ya Zhao, Meilin Jin

Journal: Front Immunol

PubMed ID: 38742108

Doi: 10.3389/fimmu.2024.1373656

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Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase

Authors: Tao Zhang, Feiyu Zhao, Jinze Li, Xiaodi Sun, Xiyun Zhang, Hejun Wang, Peng Fan, Liangxue Lai, Zhanjun Li, Tingting Sui

Journal: Nucleic Acids Res

PubMed ID: 38366553

Doi: 10.1093/nar/gkae110

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One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

Authors: Marco Malatesta, Emanuele Fornasier, Martino Luigi Di Salvo, Angela Tramonti, Erika Zangelmi, Alessio Peracchi, Andrea Secchi, Eugenia Polverini, Gabriele Giachin, Roberto Battistutta, Roberto Contestabile, Riccardo Percudani

Journal: Nat Commun

PubMed ID: 38615009

Doi: 10.1038/s41467-024-47466-3

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pH-dependent regulation of an acidophilic -acetylhomoserine sulfhydrylase from

Authors: Yasuyuki Matoba, Kosuke Oda, Maho Wataeda, Hina Kanemori, Koichi Matsuo

Journal: Appl Environ Microbiol

PubMed ID: 38568076

Doi: 10.1128/aem.00118-24

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Food for Thought: The Effects of Feeding on Neurogenesis in the Ball Python, Python regius

Authors: Hannah Bow, Christina Dang, Katherine Hillsbery, Carly Markowski, Michael Black, Christine Strand

Journal: Brain Behav Evol

PubMed ID: 38657588

Doi: 10.1159/000539052

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A conserved motif in the immune-subdominant RAP-1 related antigen of contains a B-cell epitope recognized by antibodies from protected cattle

Authors: Manuel J Rojas, Reginaldo G Bastos, Jinna Navas, Jacob M Laughery, Paul A Lacy, Carlos E Suarez

Journal: Front Immunol

PubMed ID: 38720894

Doi: 10.3389/fimmu.2024.1380660

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Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity

Authors: Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang, Changjiang Weng

Journal: PLoS Pathog

PubMed ID: 38669242

Doi: 10.1371/journal.ppat.1012146

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Development of an isotope dilution mass spectrometry assay for the quantification of insulin based on signature peptide analysis

Authors: Shangying Ma, Rimei He, Tingting Jiang, Zhishang Hu, Zihong Ye, Wei Mi

Journal: Anal Bioanal Chem

PubMed ID: 38556594

Doi: 10.1007/s00216-024-05258-0

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Specificity of DNA ADP-Ribosylation Reversal by NADARs

Authors: Bara Cihlova, Yang Lu, Andreja Mikoč, Marion Schuller, Ivan Ahel

Journal: Toxins (Basel)

PubMed ID: 38787060

Doi: 10.3390/toxins16050208

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Identification of a linear B-cell epitope on the "puff" loop of the Senecavirus A VP2 protein involved in receptor binding

Authors: Hanrong Zhou, Mingxia Sun, Shibo Su, Liang Meng, Wei Yang, Lan Yang, Xinqi Shi, Xin Li, Haiwei Wang, Hongwei Ma, Xuehui Cai, Yan-Dong Tang, Tongqing An, Fandan Meng

Journal: Front Microbiol

PubMed ID: 38716170

Doi: 10.3389/fmicb.2024.1387309

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iJAZ-based approach to engineer lepidopteran pest resistance in multiple crop species

Authors: Huijuan Mo, Huimin Chang, Ge Zhao, Guanjing Hu, Xiumei Luo, Xue Jia, Zhenlu Xu, Guangming Ren, Li Feng, Jonathan F Wendel, Xiaoya Chen, Maozhi Ren, Fuguang Li

Journal: Nat Plants

PubMed ID: 38684916

Doi: 10.1038/s41477-024-01682-3

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Blue light induced ferroptosis via STAT3/GPX4/SLC7A11/FTH1 in conjunctiva epithelium in vivo and in vitro

Authors: Qianjie Yang, Yutong Xia, Kuangqi Chen, Yinhao Wang, Dongjie Song, Jiru Zhu, Jianping Tong, Ye Shen

Journal: J Photochem Photobiol B

PubMed ID: 38663336

Doi: 10.1016/j.jphotobiol.2024.112908

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Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway

Authors: Yan Yan, Jun Xiao, Fengtao Huang, Wei Xian, Bingbing Yu, Rui Cheng, Hui Wu, Xueling Lu, Xionglue Wang, Wenjing Huang, Jing Li, Greater Kayode Oyejobi, Carol V Robinson, Hao Wu, Di Wu, Xiaoyun Liu, Longfei Wang, Bin Zhu

Journal: Nat Microbiol

PubMed ID: 38649411

Doi: 10.1038/s41564-024-01684-z

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Knockdown of heat shock protein family D member 1 (HSPD1) in lung cancer cell altered secretome profile and cancer-associated fibroblast induction

Authors: Siripat Aluksanasuwan, Keerakarn Somsuan, Jatuporn Ngoenkam, Wararat Chiangjong, Artitaya Rongjumnong, Atthapan Morchang, Somchai Chutipongtanate, Sutatip Pongcharoen

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38663552

Doi: 10.1016/j.bbamcr.2024.119736

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Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure to infected mosquito bites

Authors: Sarah Lapidus, Morgan M Goheen, Mouhamad Sy, Awa B Deme, Ibrahima Mbaye Ndiaye, Younous Diedhiou, Amadou Moctar Mbaye, Kelly A Hagadorn, Seynabou Diouf Sene, Mariama Nicole Pouye, Laty Gaye Thiam, Aboubacar Ba, Noemi Guerra, Alassane Mbengue, Hamidah Raduwan, Inés Vigan-Womas, Sunil Parikh, Albert I Ko, Daouda Ndiaye, Erol Fikrig, Yu-Min Chuang, Amy K Bei

Journal: medrxiv

PubMed ID: 38712295

Doi: 10.1101/2024.04.20.24305430

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Amino Terminal Acetylation of HOXB13 Regulates the DNA Damage Response in Prostate Cancer

Authors: Duy T Nguyen, Urvashi Mahajan, Duminduni Hewa Angappulige, Aashna Doshi, Nupam P Mahajan, Kiran Mahajan

Journal: Cancers (Basel)

PubMed ID: 38730575

Doi: 10.3390/cancers16091622

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Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing

Authors: Qiubing Chen, Xuebin Wang, Yizhou Zhang, Ming Tian, Junyi Duan, Ying Zhang, Hao Yin

Journal: NSR

Doi: 10.1093/nsr/nwae135

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Sequential release of interacting proteins and Ub-modifying enzymes by disulfide heterotypic ubiquitin reagents

Authors: Hongyi Cai, Xiangwei Wu, Junxiong Mao, Zebin Tong, Dingfei Yan, Yicheng Weng, Qingyun Zheng

Journal: Bioorganic Chemistry

PubMed ID: 38387394

Doi: 10.1016/j.bioorg.2024.107186

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Fluctuation of flavor quality in roasted duck: The consequences of raw duck preform's repetitive freeze-thawing

Authors: Ziwu Gao, Dequan Zhang, Ruiyun Wu, Jinhua He, Jiale Ma, Xiangxiang Sun, Minghui Gu, Zhenyu Wang

Journal: Food Res Int

PubMed ID: 38763675

Doi: 10.1016/j.foodres.2024.114424

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Systemic Effects of a Phage Cocktail on Healthy Weaned Piglets

Authors: Yankun Liu, Yan Lin, Weiyun Zhu

Journal: Biology (Basel)

PubMed ID: 38666883

Doi: 10.3390/biology13040271

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Expanding the Potential of Neoantigen Vaccines: Harnessing Bacille Calmette-Guérin Cell-Wall-Based Nanoscale Adjuvants for Enhanced Cancer Immunotherapy

Authors: Kangkang Liu, Jing Peng, Yunfei Guo, Yiming Li, Xiang Qi, Dengyi Duan, Taipeng Li, Jianmin Li, Yuanjie Niu, Gang Han, Yang Zhao

Journal: ACS Nano

PubMed ID: 38680054

Doi: 10.1021/acsnano.4c01691

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Visualization of the Association of Dimeric Protein Complexes on Specific Enhancers in the Salivary Gland Nuclei of Larva

Authors: Solène Vanderperre, Samir Merabet

Journal: Cells

PubMed ID: 38607052

Doi: 10.3390/cells13070613

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Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation

Authors: Mikala C Mueller, Yanmei Du, Lori A Walker, Chelsea M Magin

Journal: Matrix Biol Plus

PubMed ID: 38699486

Doi: 10.1016/j.mbplus.2024.100145

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The molecular immune modulator adenosine deaminase-1 enhances HIV specific humoral and cellular responses to a native-like HIV envelope trimer DNA vaccine

Authors: Michele A Kutzler, Gina Cusimano, David Joyner, Emily Konopka, Roshell Muir, Philip Barnette, Melanie Guderian, Iván Del Moral-Sánchez, Ronald Derking, Tom Bijl, Jonne Snitselaar, Photis Rotsides, Kyra Woloszczuk, Matthew Bell, Gabriela Canziani, Irwin Chaiken, Ann Hessell, Yannic Bartsch, Rogier Sanders, Elias Haddad

Journal: Res Sq

PubMed ID: 38746176

Doi: 10.21203/rs.3.rs-4139764/v1

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The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance

Authors: Vijay Elakkya Vijayakumar, Mookambeswaran A Vijayalakshmi, Sebastien Lacroix-Desmazes, Krishnan Venkataraman

Journal: Folia Microbiol (Praha)

PubMed ID: 38683262

Doi: 10.1007/s12223-024-01166-z

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Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy

Authors: Bo-Xin Zheng, Wei Long, Wende Zheng, Yaoxun Zeng, Xiao-Chun Guo, Ka-Hin Chan, Meng-Ting She, Alan Siu-Lun Leung, Yu-Jing Lu, Wing-Leung Wong

Journal: J Med Chem

PubMed ID: 38624086

Doi: 10.1021/acs.jmedchem.3c02240

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Developing a Novel Enzalutamide-Resistant Prostate Cancer Model via AR F877L Mutation in LNCaP Cells

Authors: Ruifeng Wang, Shuhua Ma, Nengwei Xu, Yumiao Gan, Pengya Li, Jingying Zhang, Zhixiang Zhang, Qingyang Gu, Jian Xiang

Journal: Curr Protoc

PubMed ID: 38652202

Doi: 10.1002/cpz1.1033

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Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood

Authors: Mathias Jensen, Linn Stenfelt, Jennifer Ricci Hagman, Michael Jakob Pichler, Julia Weikum, Tine Sofie Nielsen, Annika Hult, Jens Preben Morth, Martin L Olsson, Maher Abou Hachem

Journal: Nat Microbiol

PubMed ID: 38684911

Doi: 10.1038/s41564-024-01663-4

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LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation

Authors: Meng Li, Yali Hou, Yuzheng Zhou, Zhenni Yang, Hongyu Zhao, Tao Jian, Qianxi Yu, Fuxing Zeng, Xiaotian Liu, Zheng Zhang, Yan G Zhao

Journal: J Cell Biol

PubMed ID: 38587486

Doi: 10.1083/jcb.202309140

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The transcription factor BMI1 increases hypoxic signaling in oral cavity epithelia

Authors: Jorge Baquero, Xiao-Han Tang, Annalisa Ferrotta, Tuo Zhang, Krysta M DiKun, Lorraine J Gudas

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38599260

Doi: 10.1016/j.bbadis.2024.167161

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Specifically targeting antimicrobial peptides for inhibition of Candidatus Liberibacter asiaticus

Authors: Samavath Mallawarachchi, Haoqi Wang, Nirmitee Mulgaonkar, Sonia Irigoyen, Carmen Padilla, Kranthi Mandadi, James Borneman, Sandun Fernando

Journal: J Appl Microbiol

PubMed ID: 38509024

Doi: 10.1093/jambio/lxae061

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Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology

Authors: Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu, Bingfeng Liu, Xu Zhang

Journal: J Transl Med

PubMed ID: 38610029

Doi: 10.1186/s12967-024-05159-x

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Combined sensory, volatilome and transcriptome analyses identify a limonene terpene synthase as a major contributor to the characteristic aroma of a Coffea arabica L specialty coffee

Authors: Lison Marie, Jean-Christophe Breitler, Pingdwende Kader Aziz Bamogo, Mélanie Bordeaux, Séverine Lacombe, Maëlle Rios, Marc Lebrun, Renaud Boulanger, Eveline Lefort, Sunao Nakamura, Yudai Motoyoshi, Delphine Mieulet, Claudine Campa, Laurent Legendre, Benoît Bertrand

Journal: BMC Plant Biol

PubMed ID: 38566027

Doi: 10.1186/s12870-024-04890-3

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The gene "degrees of kevin bacon" (dokb) regulates a social network behaviour in Drosophila melanogaster

Authors: Rebecca Rooke, Joshua J Krupp, Amara Rasool, Mireille Golemiec, Megan Stewart, Jonathan Schneider, Joel D Levine

Journal: Nat Commun

PubMed ID: 38688961

Doi: 10.1038/s41467-024-47499-8

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Non-Invasive Delivery of Negatively Charged Nanobodies by Anodal Iontophoresis: When Electroosmosis Dominates Electromigration

Authors: Phedra Firdaws Sahraoui, Oscar Vadas, Yogeshvar N Kalia

Journal: Pharmaceutics

PubMed ID: 38675200

Doi: 10.3390/pharmaceutics16040539

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A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers

Authors: Dan-Dan Zhou, Xiao-Tian Zhai, Lan-Wen Zhang, Zi-Hui Xie, Ying Wang, Yong-Su Zhen, Rui-Juan Gao, Qing-Fang Miao

Journal: NPJ Precis Oncol

PubMed ID: 38654141

Doi: 10.1038/s41698-024-00584-z

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Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β-thalassemia

Authors: Amaliris Guerra, Nolan Hamilton, Ariel Rivera, Perry Demsko, Shuling Guo, Stefano Rivella

Journal: Am J Hematol

PubMed ID: 38659383

Doi: 10.1002/ajh.27332

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Hymenopteran-specific TRPA channel from the Texas leaf cutter ant (Atta texana) is heat and cold activated and expression correlates with environmental temperature

Authors: Julia M York, Timothy N Taylor, Sarah LaPotin, Ying Lu, Ulrich Mueller

Journal: Insect Sci

PubMed ID: 38605428

Doi: 10.1111/1744-7917.13364

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Cellugyrin (synaptogyrin-2) dependent pathways are used by bacterial cytolethal distending toxin and SARS-CoV-2 virus to gain cell entry

Authors: Kathleen Boesze-Battaglia, Gary H Cohen, Paul F Bates, Lisa M Walker, Ali Zekavat, Bruce J Shenker

Journal: Front Cell Infect Microbiol

PubMed ID: 38698905

Doi: 10.3389/fcimb.2024.1334224

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Interplay of the Tfb1 pleckstrin homology domain with Rad2 and Rad4 in transcription coupled and global genomic nucleotide excision repair

Authors: Wenzhi Gong, Hannah Holmberg, Cheng Lu, Michelle Huang, Shisheng Li

Journal: Nucleic Acids Res

PubMed ID: 38634797

Doi: 10.1093/nar/gkae286

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A DNA circuit that records molecular events

Authors: Mingzhi Zhang, Colin Yancey, Chao Zhang, Junyan Wang, Qian Ma, Linlin Yang, Rebecca Schulman, Da Han, Weihong Tan

Journal: SCIENCE ADVANCES

PubMed ID: 38578999

Doi: 10.1126/sciadv.adn3329

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ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Authors: Guy J Pearson, Harriet V Mears, Malgorzata Broncel, Ambrosius P Snijders, David L V Bauer, Jeremy G Carlton

Journal: SCIENCE ADVANCES

PubMed ID: 38569033

Doi: 10.1126/sciadv.adl5012

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Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening

Authors: Xing Li, Shiyu Sun, Wansong Zhang, Ziwei Liang, Yitong Fang, Tianhu Sun, Yong Wan, Xingcong Ma, Shuqun Zhang, Yang Xu, Ruilin Tian

Journal: Experimental & Clinical Cancer Research

PubMed ID: 38561797

Doi: 10.1186/s13046-024-03027-6

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Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

Authors: Lijing Zhang, Xuping Xie, Hannan Luo, Runtong Qian, Yang Yang, Hongtao Yu, Jing Huang, Pei-Yong Shi, Qi Hu

Journal: Cell Discov

PubMed ID: 38594245

Doi: 10.1038/s41421-024-00673-0

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Mammalian PIWI–piRNA–target complexes reveal features for broad and efficient target silencing

Authors: Zhiqing Li, Zhenzhen Li, Yuqi Zhang, Lunni Zhou, Qikui Xu, Lili Li, Lin Zeng, Junchao Xue, Huilin Niu, Jing Zhong, Qilu Yu, Dengfeng Li, Miao Gui, Yongping Huang, Shikui Tu, Zhao Zhang, Chun-Qing Song, Jianping Wu，En-Zhi Shen

Journal: Nat Struct Mol Biol

PubMed ID: 38658622

Doi: 10.1038/s41594-024-01287-6.

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Structural basis of exoribonucleasemediated mRNA transcription termination

Authors: Yuan Zeng, Hong-Wei Zhang, Xiao-Xian Wu, Yu Zhang

Journal: Nature

PubMed ID: 38538796

Doi: doi.org/10.1038/s41586-024-07240-3

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Tailored UPRE2 variants for dynamic gene regulation in yeast

Authors: Chufan Xiao, Xiufang Liu, Yuyang Pan, Yanling Li, Ling Qin, Zhibo Yan, Yunzi Feng, Mouming Zhao, Mingtao Huang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38687789

Doi: 10.1073/pnas.2315729121

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Duration of antibody response to the receptor binding domain of SARS-CoV-2 in infected or vaccinated individuals - A one year retrospective cohort study

Authors: Martin Pasev, Angelina Trifonova, Andrey Velichkov, Velislava Terzieva

Journal: Int Immunopharmacol

PubMed ID: 38621337

Doi: 10.1016/j.intimp.2024.112084

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A long-acting FGF21 attenuates metabolic dysfunction-associated steatohepatitis-related fibrosis by modulating NR4A1-mediated Ly6C phenotypic switch in macrophages

Authors: Yue Ji, Yiliang Duan, Yuanyuan Li, Qingzhou Lu, Dingkang Liu, Yifan Yang, Ruilong Chang, Jing Tian, Wenbing Yao, Jun Yin, Xiangdong Gao

Journal: Br J Pharmacol

PubMed ID: 38679486

Doi: 10.1111/bph.16378

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Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Authors: Sofie J Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M F Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher

Journal: Mol Metab

PubMed ID: 38631478

Doi: 10.1016/j.molmet.2024.101938

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HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation

Authors: Carlotta Welters, Marthe-Lina Welters, Serena Stadler, Lars Bullinger, Julian Strobel, Holger Hackstein, Arunraj Dhamodaran, Thomas Blankenstein, Leo Hansmann

Journal: Haematologica

PubMed ID: 37767552

Doi: 10.3324/haematol.2023.283812

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Synthetic Peptides Selected by Immunoinformatics as Potential Tools for the Specific Diagnosis of Canine Visceral Leishmaniasis

Authors: Gabriel Moreira, Rodrigo Maia, Nathália Soares, Thais Ostolin, Wendel Coura-Vital, Rodrigo Aguiar-Soares, Jeronimo Ruiz, Daniela Resende, Rory de Brito, Alexandre Reis, Bruno Roatt

Journal: Microorganisms

PubMed ID: 38792746

Doi: 10.3390/microorganisms12050906

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Quantitation of Enterovirus A71 Empty and Full Particles by Sedimentation Velocity Analytical Ultracentrifugation

Authors: Anna Yang, Yun Luo, Jie Yang, Tingbo Xie, Wenhui Wang, Xin Wan, Kaiwen Wang, Deqin Pang, Dongsheng Yang, Hanyu Dai, Jie Wu, Shengli Meng, Jing Guo, Zejun Wang, Shuo Shen

Journal: Viruses

PubMed ID: 38675915

Doi: 10.3390/v16040573

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Identification of PEX5-PTS1 Interaction Inhibitors through Fluorescence Polarization-Based High-Throughput Screening

Authors: Trong-Nhat Phan, Kyu-Ho Paul Park, David Shum, Joo Hwan No

Journal: Molecules

PubMed ID: 38675653

Doi: 10.3390/molecules29081835

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