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Complete microbial synthesis of crocetin and crocins from glycerol in Escherichia coli

Authors: Jun Ho Lee, Seong-Rae Lee, Sang Yup Lee, Pyung Cheon Lee

Journal: Microb Cell Fact

PubMed ID: 38178149

Doi: 10.1186/s12934-023-02287-9

Products & Services: PCR Cloning and Subcloning

Structural and functional properties of uridine 5'-monophosphate synthase from Coffea arabica

Authors: Alexis Hinojosa-Cruz, Ángel G Díaz-Sánchez, Adelaida Díaz-Vilchis, Lilian González-Segura

Journal: Int J Biol Macromol

PubMed ID: 38184030

Doi: 10.1016/j.ijbiomac.2024.129226

Products & Services: Molecular Biology Reagents

Circ_0007422 Knockdown Inhibits Tumor Property and Immune Escape of Colorectal Cancer by Decreasing PDL1 Expression in a miR-1256-Dependent Manner

Authors: Dian Yin, Li Yang, Xiu Feng, Xiaolu Zhai, Mei Hua, Jing Liu, Ying Chen

Journal: Mol Biotechnol

PubMed ID: 38253900

Doi: 10.1007/s12033-023-01040-2

Products & Services: Mutant Libraries

Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury

Authors: Ari Kwon, Na Young Lee, Jae-Hyun Yu, Myeung Gi Choi, Jeongwoo Park, Ja Hyun Koo

Journal: Cell Death Dis

PubMed ID: 38225223

Doi: 10.1038/s41419-024-06448-5

Products & Services: Proteins, Expression, Isolation and Analysis

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Authors: Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Michael L Nosella, Hongshan Zhang, T Reid Alderson, Morgan Dasovich, Anthony Leung, Ilya J Finkelstein, Julie D Forman-Kay, Hyun O Lee

Journal: biorxiv

PubMed ID: 38328070

Doi: 10.1101/2024.01.20.575817

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CFL1 restores the migratory capacity of bone marrow mesenchymal stem cells in primary Sjögren's syndrome by regulating CCR1 expression

Authors: Mengxi Huang, Panpan Zhou, Yang Hang, Dan Wu, Nan Zhao, Genhong Yao, Xiaojun Tang, Lingyun Sun

Journal: Int Immunopharmacol

PubMed ID: 38183912

Doi: 10.1016/j.intimp.2024.111485

Products & Services: Molecular Biology Reagents

A novel opsonic eCIRP inhibitor for lethal sepsis

Authors: Colleen P Nofi, Chuyi Tan, Gaifeng Ma, Molly Kobritz, Jose M Prince, Haichao Wang, Monowar Aziz, Ping Wang

Journal: J Leukoc Biol

PubMed ID: 37774691

Doi: 10.1093/jleuko/qiad119

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Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production

Authors: Sri Harsha Adusumilli, Anuthariq Alikkam Veetil, Chinmayee Choudhury, Banani Chattopadhyaya, Diptimayee Behera, Anand Kumar Bachhawat

Journal: FEBS Open Bio

PubMed ID: 38124687

Doi: 10.1002/2211-5463.13755

Products & Services: Molecular Biology Reagents

The CRISPR effector Cam1 mediates membrane depolarization for phage defence

Authors: Christian F. Baca, You Yu, Jakob T. Rostøl, Puja Majumder, Dinshaw J. Patel & Luciano A. Marraffini

Journal: Nature

PubMed ID: 38200316

Doi: 10.1038/s41586-023-06902-y

Products & Services: GenCrispr Cas9 Genome Editing

Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

Authors: Jun Wang , Jinyong Huang , Yunlong Hu , Qianwen Guo , Shasha Zhang , Jinglin Tian , Yanqin Niu , Ling Ji , Yuzhong Xu , Peijun Tang , Yaqin He , Yuna Wang , Shuya Zhang , Hao Yang , Kang Kang , Xinchun Chen , Xinying Li , Ming Yang , Deming Gou

Journal: Nat Commun

PubMed ID: 38168054

Doi: 10.1038/s41467-023-44461-y

Products & Services: Gene Synthesis

Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1-Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

Authors: Andrew V Oleinikov, Zakaria Seidu, Irina V Oleinikov, Mary Tetteh, Helena Lamptey, Michael F Ofori, Lars Hviid, Mary Lopez-Perez

Journal: J Infect Dis

PubMed ID: 37804095

Doi: 10.1093/infdis/jiad438

Products & Services: Proteins, Expression, Isolation and Analysis

Cdk5-dependent rapid formation and stabilization of dendritic spines by corticotropin-releasing factor

Authors: Dorien Vandael, Katlijn Vints, Pieter Baatsen, Małgorzata A Śliwińska, Sergio Gabarre, Lies De Groef, Lieve Moons, Vasily Rybakin, Natalia V Gounko

Journal: Transl Psychiatry

PubMed ID: 38233378

Doi: 10.1038/s41398-024-02749-7

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Authors: Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza

Journal: Pharmaceutics

PubMed ID: 38258126

Doi: 10.3390/pharmaceutics16010116

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Restricted Omicron-specific cross-variant memory B-cell immunity after a 3rd dose/booster of monovalent Wuhan-Hu-1-containing COVID-19 mRNA vaccine

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Nathaniel D Warner, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: Vaccine

PubMed ID: 38233288

Doi: 10.1016/j.vaccine.2024.01.032

Products & Services: Recombinant Proteins

Phylogenetic conservation of Trop-2 across species-rodent and primate genomics model anti-Trop-2 therapy for pre-clinical benchmarks

Authors: Emanuela Guerra, Marco Trerotola, Valeria Relli, Rossano Lattanzio, Khouloud Boujnah, Nicole Travali, Antonino Moschella, Paolo Todaro, Laura Pierdomenico, Roberta Di Pietro, Nicola Tinari, Saverio Alberti

Journal: Front Genet

PubMed ID: 38250577

Doi: 10.3389/fgene.2023.1297367

Products & Services: Gene Synthesis

Construction and characterization of a humanized rat model with its application in evaluating the uptake of different statins

Authors: Yuanjin Zhang, Junze Huang, Shengbo Huang, Jie Liu, Luyao Deng, Chenmeizi Liang, Yuanqing Guo, Bingyi Yao, Xin Wang

Journal: Acta Pharm Sin B

PubMed ID: 38572097

Doi: 10.1016/j.apsb.2023.12.019

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LINC00662 promotes melanoma progression by competitively binding miR-107 and activating the β-catenin signaling pathway

Authors: Mengmeng Luo, Rui Lei, Qingfang Zhao, Yichen Shen, Zhigang He, Jinghong Xu

Journal: Int J Med Sci

PubMed ID: 38169586

Doi: 10.7150/ijms.84072

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Precise coordination between nutrient transporters ensures fertility in the malaria mosquito Anopheles gambiae

Authors: Iryna Stryapunina, Maurice A Itoe, Queenie Trinh, Charles Vidoudez, Esrah Du, Lydia Mendoza, Oleksandr Hulai, Jamie Kauffman, John Carew, W Robert Shaw, Flaminia Catteruccia

Journal: PLoS Genet

PubMed ID: 38285728

Doi: 10.1371/journal.pgen.1011145

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Delivery of mRNA with Histidine-Lysine Peptides

Authors: Qixin Leng, Jiaxi He, Aishwarya Anand, A James Mixson

Journal: Methods Mol Biol

PubMed ID: 38907929

Doi: 10.1007/978-1-0716-3918-4_23

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Leafhopper salivary vitellogenin mediates virus transmission to plant phloem

Authors: Yanfei Wang , Chengcong Lu , Shude Guo , Yuxin Guo , Taiyun Wei , Qian Chen

Journal: Nat Commun

PubMed ID: 38167823

Doi: 10.1038/s41467-023-43488-5

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Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs

Authors: Yingli Zhu, Thibaut Burg, Katrien Neyrinck, Tim Vervliet, Fatemeharefeh Nami, Ellen Vervoort, Karan Ahuja, Maria Livia Sassano, Yoke Chin Chai, Arun Kumar Tharkeshwar, Jonathan De Smedt, Haibo Hu, Geert Bultynck, Patrizia Agostinis, Johannes V. Swinnen, Ludo Van Den Bosch, Rodrigo Furtado Madeiro da Costa & Catherine Verfaillie

Journal: Acta Neuropathologica

PubMed ID: 38395965

Doi: 10.1007/s00401-023-02666-x

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LATS2 condensates organize signalosomes for Hippo pathway signal transduction

Authors: Min Qin, Ershuo Geng, Jingning Wang, Man Yu, Tianqi Dong, Shasha Li, Xiao Zhang, Jiaming Lin, Mingjun Shi, Juebei Li, Huixia Zhang, Lian Chen, Xiaolei Cao, Liu Huang, Mingwei Wang, Yan Li, Xiang-ping Yang, Bin Zhao & Shuguo Sun

Journal: Nature Chemical Biology

PubMed ID: 38200110

Doi: 10.1038/s41589-023-01516-x

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Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

Authors: Anna Worthmann , Julius Ridder , Sharlaine Y L Piel , Ioannis Evangelakos , Melina Musfeldt , Hannah Voß , Marie O'Farrell , Alexander W Fischer , Sangeeta Adak , Monica Sundd , Hasibullah Siffeti , Friederike Haumann , Katja Kloth , Tatjana Bierhals , Markus Heine , Paul Pertzborn , Mira Pauly , Julia-Josefine Scholz , Suman Kundu , Marceline M Fuh , Axel Neu , Klaus Tödter , Maja Hempel , Uwe Knippschild , Clay F Semenkovich , Hartmut Schlüter , Joerg Heeren , Ludger Scheja , Christian Kubisch , Christian Schlein

Journal: Nat Commun

PubMed ID: 38167725

Doi: 10.1038/s41467-023-44364-y

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Rif2 interaction with Rad50 counteracts Tel1 functions in checkpoint signalling and DNA tethering by releasing Tel1 from MRX binding

Authors: Paolo Pizzul, Erika Casari, Carlo Rinaldi, Marco Gnugnoli, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese

Journal: Nucleic Acids Res

PubMed ID: 38180815

Doi: 10.1093/nar/gkad1246

Products & Services: Gene Synthesis

A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease

Authors: Su-Jeong Kim, Brendan Miller, Nicolas G Hartel, Ricardo Ramirez, Regina Gonzalez Braniff, Naphada Leelaprachakul, Amy Huang, Yuzhu Wang, Thalida Em Arpawong, Eileen M Crimmins, Penglong Wang, Xianbang Sun, Chunyu Liu, Daniel Levy, Kelvin Yen, Giselle M Petzinger, Nicholas A Graham, Michael W Jakowec, Pinchas Cohen

Journal: Mol Psychiatry

PubMed ID: 38167865

Doi: 10.1038/s41380-023-02344-0

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Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination

Authors: Fatima Amer-Sarsour, Daniel Falik, Yevgeny Berdichevsky, Alina Kordonsky, Sharbel Eid, Tatiana Rabinski, Hasan Ishtayeh, Stav Cohen-Adiv, Itzhak Braverman, Sergiu C Blumen, Tal Laviv, Gali Prag, Gad D Vatine, Avraham Ashkenazi

Journal: EMBO J

PubMed ID: 38177505

Doi: 10.1038/s44318-023-00018-9

The Chinese Hamster Ovary Cell-Based H9 HA Subunit Avian Influenza Vaccine Provides Complete Protection against the H9N2 Virus Challenge in Chickens

Authors: Shunfan Zhu, Zhenyu Nie, Ying Che, Jianhong Shu, Sufang Wu, Yulong He, Youqiang Wu, Hong Qian, Huapeng Feng, Qiang Zhang

Journal: Viruses

PubMed ID: 38275973

Doi: 10.3390/v16010163

Products & Services: Molecular Biology Reagents

Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain

Authors: Michele Monti, Edoardo Milanetti, Myrthe T Frans, Mattia Miotto, Lorenzo Di Rienzo, Maksim V Baranov, Giorgio Gosti, Arun Kumar Somavarapu, Madhu Nagaraj, Thaddeus W Golbek, Emiel Rossing, Sam J Moons, Thomas J Boltje, Geert van den Bogaart, Tobias Weidner, Daniel E Otzen, Gian Gaetano Tartaglia, Giancarlo Ruocco, Steven J Roeters

Journal: J Phys Chem B

PubMed ID: 38190651

Doi: 10.1021/acs.jpcb.3c06258

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A fast and easy one-step purification strategy for plant-made antibodies using Protein A magnetic beads

Authors: Loïc Faye, Clemens Grünwald-Gruber, Louis-Philippe Vezina, Véronique Gomord, Bertrand Morel

Journal: Front Plant Sci

PubMed ID: 38235198

Doi: 10.3389/fpls.2023.1276148

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Structure of a tripartite protein complex that targets toxins to the type VII secretion system

Authors: Timothy A Klein, Prakhar Y Shah, Polyniki Gkragkopoulou, Dirk W Grebenc, Youngchang Kim, John C Whitney

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38194450

Doi: 10.1073/pnas.2312455121

Products & Services: Proteins, Expression, Isolation and Analysis

Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients

Authors: Caroline C Traut, Joyce L Jones, Renata A Sanders, Laura R Clark, Matthew M Hamill, Georgia Stavrakis, Joel Sop, Tyler P Beckey, Sara C Keller, Elizabeth A Gilliams, Willa V Cochran, Oliver Laeyendecker, Yukari C Manabe, Heba H Mostafa, David L Thomas, Bhakti Hansoti, Kelly A Gebo, Joel N Blankson

Journal: J Infect Dis

PubMed ID: 37380166

Doi: 10.1093/infdis/jiad245

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Synthesis and mechanistic study of ultrashort peptides that inhibits Alzheimer's Aβ-aggregation-induced neurotoxicity

Authors: Naina Sehra, Rajesh Parmar, Indresh K Maurya, Vinod Kumar, Kulbhushan Tikoo, Rahul Jain

Journal: Bioorg Chem

PubMed ID: 38309001

Doi: 10.1016/j.bioorg.2024.107159

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Jianpi Antai formula prevents miscarriage by repressing M1 polarization of decidual macrophages through ubiquitination of NLRP3 mediated by MARCH7

Authors: Ying Zhao, Chenyun Miao, Ruye Wang, Yun Chen, Ning Ren, Jing Ma, Tao Gao, Qin Zhang

Journal: J Ethnopharmacol

PubMed ID: 38246482

Doi: 10.1016/j.jep.2024.117796

Products & Services: Proteins, Expression, Isolation and Analysis

A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathy

Authors: Maryamsadat Seyedsadr, Madison Bang, Ethan McCarthy, Shirley Zhang, Ho-Chung Chen, Mahnia Mohebbi, Willy Hugo, Jason K Whitmire, Melissa G Lechner, Maureen A Su

Journal: biorxiv

PubMed ID: 38260637

Doi: 10.1101/2024.01.07.574553

Products & Services: ORF cDNA Clones/MolecularCloud

Molecular mechanisms and evolutionary robustness of a color switch in proteorhodopsins

Authors: Jiafei Mao, Xinsheng Jin, Man Shi, David Heidenreich, Lynda J Brown, Richard C D Brown, Moreno Lelli, Xiao He, Clemens Glaubitz

Journal: Sci Adv

PubMed ID: 38266078

Doi: 10.1126/sciadv.adj0384

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Polysaccharides Produced by Plant Growth-Promoting Rhizobacteria Strain sp BK01 Enhance Salt Stress Tolerance to

Authors: Enni Chen, Changsheng Yang, Weiyi Tao, Shuang Li

Journal: Polymers (Basel)

PubMed ID: 38201810

Doi: 10.3390/polym16010145

Products & Services: DNA Sequencing

Enantioselective Toxicity and Potential Endocrine-Disruptive Effects of the Insecticides Flufiprole and Ethiprole on

Authors: Lianshan Li, Xuejun Zhao, Kunming Hu, Weiye Xu, Minghua Wang, Hongjie Wang

Journal: J Agric Food Chem

PubMed ID: 38190123

Doi: 10.1021/acs.jafc.3c07896

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An inoculation site-retained mRNA vaccine induces robust immune responses against SARS-CoV-2 variants

Authors: Lei Huang, Fanfan Zhao, Muye He, Yi Fang, Xiaoping Ma, Shuaiyao Lu, Entao Li, Hui Xiao, Hanfei Zhu, Xueli Wang, Siyuan Tang, Bo Yu, Jie Wang, Dong Zhao, Chao Wang, Hangwen Li, Yuwei Gao, Xiaozhong Peng, Haifa Shen

Journal: J Control Release

PubMed ID: 38184234

Doi: 10.1016/j.jconrel.2024.01.002

Products & Services: Recombinant Proteins

Herpes simplex virus type 1 modifies the protein composition of extracellular vesicles to promote neurite outgrowth and neuroinfection

Authors: Guorong Sun, Kai Alexander Kropp, Marieluise Kirchner, Nina Plückebaum, Anton Selich, Manutea Serrero, Akshay Dhingra, Jorge Rubén Cabrera, Birgit Ritter, Rudolf Bauerfeind, Emanuel Wyler, Markus Landthaler, Axel Schambach, Beate Sodeik, Philipp Mertins, Abel Viejo-Borbolla

Journal: MBio

PubMed ID: 38275838

Doi: 10.1128/mbio.03308-23

Products & Services: Codon Optimization

Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction

Authors: Marta S Alexdottir, Martin Pehrsson, Viktor Domislovic, Line E Godskesen, Aleksander Krag, Jens Kjeldsen, Marko Brinar, Ana Barisic, Anne-Christine Bay-Jensen, Morten A Karsdal, Zeljko Krznaric, Joachim H Mortensen

Journal: Sci Rep

PubMed ID: 38238446

Doi: 10.1038/s41598-024-52208-y

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TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation

Authors: Xue Hao, Bo Zhao, Martina Towers, Liping Liao, Edgar Luzete Monteiro, Xin Xu, Christina Freeman, Hongzhuang Peng, Hsin-Yao Tang, Aaron Havas, Andrew V Kossenkov, Shelley L Berger, Peter D Adams, David W Speicher, David Schultz, Ronen Marmorstein, Kenneth S Zaret, Rugang Zhang

Journal: Nat Aging

PubMed ID: 38267705

Doi: 10.1038/s43587-023-00564-1

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Material assembly from collective action of shape-changing polymers

Authors: Mustafa K Abdelrahman, Robert J Wagner, Manivannan Sivaperuman Kalairaj, Mason Zadan, Min Hee Kim, Lindy K Jang, Suitu Wang, Mahjabeen Javed, Asaf Dana, Kanwar Abhay Singh, Sarah E Hargett, Akhilesh K Gaharwar, Carmel Majidi, Franck J Vernerey, Taylor H Ware

Journal: Nat Mater

PubMed ID: 38177377

Doi: 10.1038/s41563-023-01761-4

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Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer's Disease

Authors: Song-I Seol, Dashdulam Davaanyam, Sang-A Oh, Eun-Hwa Lee, Pyung-Lim Han, Seung-Woo Kim, Ja-Kyeong Lee

Journal: Cells

PubMed ID: 38247880

Doi: 10.3390/cells13020189

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Combined Immunoinformatics to Design and Evaluate a Multi-Epitope Vaccine Candidate against Infection

Authors: Song Liang, Shidan Zhang, Yinli Bao, Yumin Zhang, Xinyi Liu, Huochun Yao, Guangjin Liu

Journal: Vaccines (Basel)

PubMed ID: 38400121

Doi: 10.3390/vaccines12020137

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Knock-in mutagenesis in Drosophila Rdl underscores the critical role of the conserved M3 glycine in mediating the actions of broflanilide and isocycloseram on GABA receptors

Authors: Yoshihisa Ozoe, Toshifumi Nakao, Shu Kondo, Yasuhide Yoshioka, Fumiyo Ozoe, Shinichi Banba

Journal: Pestic Biochem Physiol

PubMed ID: 38458683

Doi: 10.1016/j.pestbp.2024.105776

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Screening and Identification of Anti-Idiotypic Nanobody Capable of Broad-Spectrum Recognition of the Toxin Binding Region of Lepidopteran Cadherins and Mimicking Domain II of Cry2Aa Toxin

Authors: Cheng Shen, Jiafeng Jin, Ziyan Huang, Meng Meng, Manman Lin, Xiaodan Hu, Qing Zhu, Chongxin Xu, Wei Chen, Johnson Lin, Xiao Zhang, Yuan Liu, Xianjin Liu

Journal: J Agric Food Chem

PubMed ID: 38221880

Doi: 10.1021/acs.jafc.3c07295

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PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

Authors: Nagaraja Chappidi 1, Thomas Quail 2, Simon Doll 3, Laura T Vogel 4, Radoslav Aleksandrov 5, Suren Felekyan 4, Ralf Kühnemuth 4, Stoyno Stoynov 5, Claus A M Seidel 4, Jan Brugués 6, Marcus Jahnel 3, Titus M Franzmann 1, Simon Alberti

Journal: Cell

PubMed ID: 38320550

Doi: 10.1016/j.cell.2024.01.015

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Quaternization drives spleen-to-lung tropism conversion for mRNA-loaded lipid-like nanoassemblies

Authors: Yixuan Huang , Jiacai Wu , Sanpeng Li , Zhen Liu , Zhenghua Li , Boping Zhou , Bin Li

Journal: Theranostics

PubMed ID: 38169552

Doi: 10.7150/thno.90071

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High-Yield Lasso Peptide Production in a Bacterial Host by Plasmid Copy Number Engineering

Authors: Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio

Journal: ACS Synth Biol

PubMed ID: 38194362

Doi: 10.1021/acssynbio.3c00597

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PlzA is a cyclic-di-GMP dependent DNA and RNA binding protein

Authors: Nerina Jusufovic, Andrew C Krusenstjerna, Christina R Savage, Timothy C Saylor, Catherine A Brissette, Wolfram R Zückert, Paula J Schlax, Md A Motaleb, Brian Stevenson

Journal: biorxiv

PubMed ID: 36778503

Doi: 10.1101/2023.01.30.526351

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LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL

Authors: Nadine Weinelt, Kaja Nicole Wächtershäuser, Gulustan Celik, Birte Jeiler, Isabelle Gollin, Laura Zein, Sonja Smith, Geoffroy Andrieux, Tonmoy Das, Jens Roedig, Leonard Feist, Björn Rotter, Melanie Boerries, Francesco Pampaloni, Sjoerd J L van Wijk

Journal: Cell Death Dis

PubMed ID: 38245534

Doi: 10.1038/s41419-024-06447-6

Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar ()

Authors: Paolo Valentini, Srinivas Akula, Abigail Alvarado-Vazquez, Jenny Hallgren, Zhirong Fu, Brett Racicot, Ingo Braasch, Michael Thorpe, Lars Hellman

Journal: Int J Mol Sci

PubMed ID: 38338947

Doi: 10.3390/ijms25031669

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USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication

Authors: Hannah L Mackay, Helen R Stone, Katherine Ellis, George E Ronson, Alexandra K Walker, Katarzyna Starowicz, Alexander J Garvin, Patrick van Eijk, Alina Vaitsiankova, Sobana Vijayendran, James F Beesley, Eva Petermann, Eric J Brown, Ruth M Densham, Simon H Reed, Felix Dobbs, Marco Saponaro, Joanna R Morris

Journal: biorxiv

PubMed ID: 38260523

Doi: 10.1101/2024.01.10.574674

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NRF2 mutation enhances the immune escape of hepatocellular carcinoma by reducing STING activation

Authors: Cheng Li, Gang Liang, Ke Yan, Yongheng Wang

Journal: Biochem Biophys Res Commun

PubMed ID: 38271834

Doi: 10.1016/j.bbrc.2024.149536

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Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria

Authors: Sabine Poerschke, Silke Oeljeklaus, Luis Daniel Cruz-Zaragoza, Alexander Schenzielorz, Drishan Dahal, Hauke Sven Hillen, Hirak Das, Laura Sophie Kremer, Anusha Valpadashi, Mirjam Breuer, Johannes Sattmann, Ricarda Richter-Dennerlein, Bettina Warscheid, Sven Dennerlein, Peter Rehling

Journal: Cell

PubMed ID: 38199007

Doi: 10.1016/j.molcel.2023.12.013

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Structure basis for recognition of plant Rpn10 by phytoplasma SAP05 in ubiquitin-independent protein degradation

Authors: Liying Zhang, Yunxiang Du, Qian Qu, Qingyun Zheng

Journal: iScience

PubMed ID: 38322988

Doi: 10.1016/j.isci.2024.108892

Products & Services: Proteins, Expression, Isolation and Analysis

Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis

Authors: Zhong-Hao Ji, Wen-Yin Xie , Pei-Sen Zhao , Hong-Yu Wu , Wen-Zhi Ren , Jin-Ping Hu , Wei Gao , Bao Yuan

Journal: Nutrients .

PubMed ID: 38140314

Doi: 10.3390/nu15245055

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Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function

Authors: Leonardo A Parra-Rivas , Kayalvizhi Madhivanan , Brent D Aulston , Lina Wang , Dube Dheeraj Prakashchand , Nicholas P Boyer , Veronica M Saia-Cereda , Kristen Branes-Guerrero , Donald P Pizzo , Pritha Bagchi , V S Sundar , Yong Tang , Utpal Das , David A Scott , Padmini Rangamani , Yuki Ogawa , Subhojit Roy

Journal: Neuron .

PubMed ID: 38128479

Doi: 10.1016/j.neuron.2023.11.020

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Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics

Authors: Elad Arad , Kasper B Pedersen , Orit Malka, Sisira Mambram Kunnath , Nimrod Golan , Polina Aibinder , Birgit Schiøtt , Hanna Rapaport, Meytal Landau , Raz Jelinek

Journal: Nat Commun .

PubMed ID: 38081813

Doi: s41467-023-43624-1

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Molecular mechanism of allosteric activation of the CRISPR ribonuclease Csm6 by cyclic tetra-adenylate

Authors: Liyang Du , Qinwei Zhu & Zhonghui Lin

Journal: The EMBO Journal

Doi: 10.1038/s44318-023-00017-w

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Structural dynamics of the CROPs domain control stability and toxicity of Paeniclostridium sordellii lethal toxin

Authors: Yao Zhou, Xiechao Zhan , Jianhua Luo, Diyin Li , Ruoyu Zhou , Jiahao Zhang , Zhenrui Pan , Yuanyuan Zhang , Tianhui Jia , Xiaofeng Zhang , Yanyan Li , Liang Tao

Journal: Nat Commun .

PubMed ID: 38114525

Doi: 10.1038/s41467-023-44169-z

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Structural analysis and functional evaluation of the disordered ß–hexosyltransferase region from Hamamotoa (Sporobolomyces) singularis

Authors: Suzanne F Dagher, Asmita Vaishnav, Christopher B Stanley, Flora Meilleur, Brian F P Edwards , José M Bruno-Bárcena

Journal: Front Bioeng Biotechnol

PubMed ID: 38162180

Doi: 10.3389/fbioe.2023.1291245

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Engineering minimal tissue inhibitors of metalloproteinase targeting MMPs via gene shuffling and yeast surface display

Authors: Arman Hosseini, Sachin Kumar, Kyle Hedin, Maryam Raeeszadeh-Sarmazdeh

Journal: Protein Sci

PubMed ID: 37807423

Doi: 10.1002/pro.4795

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A functional and structural comparative analysis of Large Tumor Antigens reveals evolution of different importin α-dependent nuclear localization signals

Authors: Emily M Cross, Nasim Akbari, Hanieh Ghassabian, Mikayla Hoad, Silvia Pavan, Daryl Ariawan, Camilla M Donnelly, Enrico Lavezzo, Gayle F Petersen, Jade K Forwood, Gualtiero Alvisi

Journal: Protein Sci

PubMed ID: 38108201

Doi: 10.1002/pro.4876

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Choosing the right mouse model: comparison of humanized NSG and NBSGW mice for in vivo HSC gene therapy

Authors: Seunga Choo, Carl B Wolf, Heather M Mack, Mitchell J Egan, Hans-Peter Kiem, Stefan Radtke

Journal: Blood Adv

PubMed ID: 38113461

Doi: 10.1182/bloodadvances.2023011371

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A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity

Authors: Solange Moréra, Armelle Vigouroux, Magali Aumont-Nicaise, Mohammed Ahmar, Thibault Meyer, Abbas El Sahili, Grégory Deicsics, Almudena González-Mula, Sizhe Li, Jeanne Doré, Serena Siragu, Pierre Legrand, Camille Penot, François Andrè, Denis Faure, Laurent Soulère, Yves Queneau, Ludovic Vial

Journal: Biochem J

PubMed ID: 38058289

Doi: 10.1042/BCJ20230273

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Secretory carrier-associated membrane protein 5 regulates cell-surface targeting of T-type calcium channels

Authors: Emilio R Mustafá, Konstantin Weiß, Norbert Weiss

Journal: Channels (Austin)

PubMed ID: 37389974

Doi: 10.1080/19336950.2023.2230776

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Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family

Authors: Benoit Arragain, Martin Pelosse, Albert Thompson, Stephen Cusack

Journal: Nat Commun

PubMed ID: 38066000

Doi: 10.1038/s41467-023-44044-x

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N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells

Authors: Jie Lai, Zhiyong Zhou, Kan Hu, HongLong Yu, Xingyao Su, Xiaoqiang Niu, Huizi Li, Shengxun Mao

Journal: Epigenetics

PubMed ID: 38145548

Doi: 10.1080/15592294.2023.2298058

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Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study

Authors: Yunlin Zhang, Ruchi P Patel, Ki Hyun Kim, Hyungwoo Cho, Jae-Cheol Jo, Seong Hyun Jeong, Sung Yong Oh, Yoon Seok Choi, Sung Hyun Kim, Ji Hyun Lee, Mathew Angelos, Puneeth Guruprasad, Ivan Cohen, Ositadimma Ugwuanyi, Yong Gu Lee, Raymone Pajarillo, Jong Hyun Cho, Alberto Carturan, Luca Paruzzo, Guido Ghilardi, Michael Wang, Soohwan Kim, Sung-Min Kim, Hyun-Jong Lee, Ji-Ho Park, Leiguang Cui, Tae Bum Lee, In-Sik Hwang, Young-Ha Lee, Yong-Jun Lee, Patrizia Porazzi, Dongfang Liu, Yoon Lee, Jong-Hoon Kim, Jong-Seo Lee, Dok Hyun Yoon, Junho Chung, Marco Ruella

Journal: Mol Cancer

PubMed ID: 38066564

Doi: 10.1186/s12943-023-01886-9

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Plasma circRNA HIPK2 as a putative biomarker for the diagnosis and prediction of therapeutic effects in major depressive disorder

Authors: Xiaoyu Yu, Zhenyu Fan, Tingting Yang, Heng Li, Yachen Shi, Long Ye, Rongrong Huang

Journal: Clin Chim Acta

PubMed ID: 38065380

Doi: 10.1016/j.cca.2023.117694

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A biosynthetic network for protoberberine production in

Authors: Linrui Wu, Binxin Zhao, Zixin Deng, Bin Wang, Yi Yu

Journal: Hortic Res

PubMed ID: 38282690

Doi: 10.1093/hr/uhad259

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DPY30 promotes colorectal carcinoma metastasis by upregulating ZEB1 transcriptional expression

Authors: Chun-Ying Luo, Wei-Chao Su, Hai-Feng Jiang, Ling-Tao Luo, Dong-Yan Shen, Guo-Qiang Su

Journal: Cancer Cell Int

PubMed ID: 38115111

Doi: 10.1186/s12935-023-03126-y

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Recombinant bovine FGF1 promotes muscle satellite cells mitochondrial fission and proliferation in serum-free conditions

Authors: Qingying Liu, Lianghua Xie, Wei Chen

Journal: Food Res Int

PubMed ID: 38129067

Doi: 10.1016/j.foodres.2023.113794

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Dachsous and Fat coordinately repress the Dachs–Dlish–Approximated complex to control growth

Authors: Hitoshi Matakatsu , Richard G Fehon

Journal: J Cell Biol

PubMed ID: 39373700

Doi: 10.1083/jcb.202406119

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Intranasal mask for protecting the respiratory tract against viral aerosols

Authors: Xiaoming Hu, Shuang Wang, Shaotong Fu, Meng Qin, Chengliang Lyu, Zhaowen Ding, Yan Wang, Yishu Wang, Dongshu Wang, Li Zhu, Tao Jiang, Jing Sun, Hui Ding, Jie Wu, Lingqian Chang, Yimin Cui, Xiaocong Pang, Youchun Wang, Weijin Huang, Peidong Yang, Limin Wang, Guanghui Ma, Wei Wei

Journal: Nat Commun

PubMed ID: 38110357

Doi: 10.1038/s41467-023-44134-w

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Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs

Authors: Krystal C Johnson, Audrius Kilikevicius, Cristina Hofman, Jiaxin Hu, Yang Liu, Selina Aguilar, Jon Graswich, Yi Han, Tao Wang, Jill M Westcott, Rolf A Brekken, Lan Peng, Georgios Karagkounis, David R Corey

Journal: Nucleic Acids Res

PubMed ID: 38109320

Doi: 10.1093/nar/gkad1155

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Electrostatic-Dominated Conformational Fluctuations and Transition States of Phase Separation in Charge-Balanced Protein Polymer

Authors: Sougat Das, Tithi Basu, Saptarshi Majumdar

Journal: ACS Macro Lett

PubMed ID: 38109356

Doi: 10.1021/acsmacrolett.3c00625

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Sensitive Blood-Based Detection of HIV-1 and Mycobacterium tuberculosis Peptides for Disease Diagnosis by Immuno-Affinity Liquid Chromatography-Tandem Mass Spectrometry: A Method Development and Proof-of-Concept Study

Authors: Lin Li, Christopher J Lyon, Sylvia M LaCourse, Wenshu Zheng, Joshua Stern, Jaclyn N Escudero, Wilfred Bundi Murithi, Lilian Njagi, Grace John-Stewart, Thomas R Hawn, Videlis Nduba, Wael Abdelgaliel, Thomas Tombler, David Horne, Li Jiang, Tony Y Hu

Journal: Clin Chem

PubMed ID: 37956323

Doi: 10.1093/clinchem/hvad173

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Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs

Authors: Erik A Williams, Ajay Ravindranathan, Rohit Gupta, Nicholas O Stevers, Abigail K Suwala, Chibo Hong, Somang Kim, Jimmy Bo Yuan, Jasper Wu, Jairo Barreto, Calixto-Hope G Lucas, Emily Chan, Melike Pekmezci, Philip E LeBoit, Thaddeus Mully, Arie Perry, Andrew Bollen, Jessica Van Ziffle, W Patrick Devine, Alyssa T Reddy, Nalin Gupta, Kristen M Basnet, Robert J B Macaulay, Patrick Malafronte, Han Lee, William H Yong, Kevin Jon Williams, Tareq A Juratli, Douglas A Mata, Richard S P Huang, Matthew C Hiemenz, Dean C Pavlick, Garrett M Frampton, Tyler Janovitz, Jeffrey S Ross, Susan M Chang, Mitchel S Berger, Line Jacques, Jun S Song, Joseph F Costello, David A Solomon

Journal: Neuro Oncol

PubMed ID: 37436963

Doi: 10.1093/neuonc/noad121

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Phage Tail Fiber Protein as a Specific Probe for Recognition of Shiga Toxin-Producing O91, O103, and O111

Authors: Yibao Chen, Lulu Li, Xiaotian Wei, Ming Hu, Xiaonan Zhao, Qing Zhang, Yanbo Luo, Min Zhao, Zhengjie Liu, Yumei Cai, Yuqing Liu

Journal: Anal Chem

PubMed ID: 38053255

Doi: 10.1021/acs.analchem.3c03370

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The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways

Authors: Rayene Berkane, Hung Ho-Xuan, Marius Glogger, Pablo Sanz-Martinez, Lorène Brunello, Tristan Glaesner, Santosh Kumar Kuncha, Katharina Holzhüter, Sara Cano-Franco, Viviana Buonomo, Paloma Cabrerizo-Poveda, Ashwin Balakrishnan, Georg Tascher, Koraljka Husnjak, Thomas Juretschke, Mohit Misra, Alexis González, Volker Dötsch, Paolo Grumati, Mike Heilemann, Alexandra Stolz

Journal: Nat Commun

PubMed ID: 38102139

Doi: 10.1038/s41467-023-44101-5

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Ubiquitin-specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma

Authors: Qianwei Ye, Wei Zhou, Shengjun Xu, Qingyang Que, Qifan Zhan, Lincheng Zhang, Shusen Zheng, Sunbin Ling, Xiao Xu

Journal: MedComm (2020)

PubMed ID: 38045832

Doi: 10.1002/mco2.439

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Authors: Yunxiang Zhao, Jiali Qin, Jingshuai Sun, Jian He, Yanmei Sun, Renqiang Yuan, Zhili Li

Journal: Theriogenology

PubMed ID: 38150851

Doi: 10.1016/j.theriogenology.2023.11.028

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Addressing the Binding Mechanism of the Meprin and TRAF-C Homology Domain of the Speckle-Type POZ Protein Using Protein Engineering

Authors: Awa Diop, Paola Pietrangeli, Valeria Pennacchietti, Livia Pagano, Angelo Toto, Mariana Di Felice, Sara Di Matteo, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni

Journal: Int J Mol Sci

PubMed ID: 38139193

Doi: 10.3390/ijms242417364

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Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects

Authors: Jingan Chen, Yue Xu, Muye Zhou, Shufen Xu, Andrew James Varley, Alex Golubovic, Rick Xing Ze Lu, Kevin Chang Wang, Mina Yeganeh, Daniel Vosoughi, Bowen Li

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38060560

Doi: 10.1073/pnas.2309472120

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The role of CE16 exo-deacetylases in hemicellulolytic enzyme mixtures revealed by the biochemical and structural study of the novel TtCE16B esterase

Authors: Christina Pentari, Anastasia Zerva, Christos Kosinas, Panagiota Karampa, Vladimír Puchart, Maria Dimarogona, Evangelos Topakas

Journal: Carbohydr Polym

PubMed ID: 38171682

Doi: 10.1016/j.carbpol.2023.121667

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A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis

Authors: Helena Port, Cecilie Møller Hausgaard, Yi He, Walter P Maksymowych, Stephanie Wichuk, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Signe Holm Nielsen

Journal: Sci Rep

PubMed ID: 38066013

Doi: 10.1038/s41598-023-48787-x

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Rapid detection of in sputum using CRISPR-Cas12b combined with cross-priming amplification in a single reaction

Authors: Lijun Peng, Tingting Fang, Qingshan Cai, Hao Li, Huanyu Li, Haiqiong Sun, Mingzhi Zhu, Lingshan Dai, Yanqin Shao, Long Cai

Journal: J Clin Microbiol

PubMed ID: 38112450

Doi: 10.1128/jcm.00923-23

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Development of a double-antibody sandwich enzyme-linked immunosorbent assay for rapid detection of VZV

Authors: Aiping Wang, Na Liu, Jianguo Zhao, Yan Niu, Yumei Chen, Jingming Zhou, Enping Liu, Gaiping Zhang

Journal: J Virol Methods

PubMed ID: 38154579

Doi: 10.1016/j.jviromet.2023.114874

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Superior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

Authors: Jaime S Rosa Duque, Samuel M S Cheng, Carolyn A Cohen, Daniel Leung, Xiwei Wang, Xiaofeng Mu, Yuet Chung, Tsun Ming Lau, Manni Wang, Wenyue Zhang, Yanmei Zhang, Howard H W Wong, Leo C H Tsang, Sara Chaothai, Tsz Chun Kwan, John K C Li, Karl C K Chan, Leo L H Luk, Jenson C H Ho, Wing Yan Li, Amos M T Lee, Jennifer H Y Lam, Sau Man Chan, Wilfred H S Wong, Issan Y S Tam, Masashi Mori, Sophie A Valkenburg, Malik Peiris, Wenwei Tu, Yu Lung Lau

Journal: World J Pediatr

PubMed ID: 38085470

Doi: 10.1007/s12519-023-00764-0

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Intracellular cholesterol visualization in brain tissue using D4H

Authors: Sherida M de Leeuw, Tal Nuriel

Journal: STAR Protoc

PubMed ID: 38100357

Doi: 10.1016/j.xpro.2023.102779

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Molecular Characterization of Tick-borne Pathogens in Bactrian Camels and Ticks from Gansu Province, China

Authors: Hong-Xi Zhao, Xiao-Qing Zan, Jin-Zhong Tao, Xin-Gang Dan