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N-acetyltransferase 10 regulates alphavirus replication via N4- acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA

Authors: Yamei Dang , Jia Li , Yuchang Li , Yuan Wang , Yajing Zhao , Ningbo Zhao , Wanying Li , Hui Zhang , Chuantao Ye , Hongwei Ma , Liang Zhang , He Liu , Yangchao Dong , Min Yao , Yingfeng Lei , Zhikai Xu , Fanglin Zhang , Wei Ye

Journal: J Virol .

PubMed ID: 38169284

Doi: 10.1128/jvi.01350-23

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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Authors: Gisele Nishiguchi , Lauren G Mascibroda , Sarah M Young , Elizabeth A Caine , Sherif Abdelhamed , Jeffrey J Kooijman , Darcie J Miller , Sourav Das , Kevin McGowan , Anand Mayasundari , Zhe Shi , Juan M Barajas , Ryan Hiltenbrand , Anup Aggarwal , Yunchao Chang , Vibhor Mishra , Shilpa Narina , Melvin Thomas , Allister J Loughran , Ravi Kalathur , Kaiwen Yu , Suiping Zhou , Xusheng Wang , Anthony A High , Junmin Peng , Shondra M Pruett-Miller , Danette L Daniels , Marjeta Urh , Anang A Shelat , Charles G Mullighan , Kristin M Riching , Guido J R Zaman , Marcus Fischer , Jeffery M Klco , Zoran Rankovic

Journal: Nat Commun

PubMed ID: 38228616

Doi: 10.1038/s41467-024-44698-1

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Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Authors: Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang , Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao

Journal: Nature

PubMed ID: 37993710

Doi: 10.1038/s41586-023-06753-7

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Structural basis of Gabija anti-phage defence and viral immune evasion

Authors: Sadie P Antine, Alex G Johnson, Sarah E Mooney, Azita Leavitt, Megan L Mayer, Erez Yirmiya, Gil Amitai, Rotem Sorek, Philip J Kranzusch

Journal: Nature

PubMed ID: 37992757

Doi: 10.1038/s41586-023-06855-2

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A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover

Authors: David S Glass 1, Anat Bren 2, Elizabeth Vaisbourd 2, Avi Mayo 2, Uri Alon

Journal: Cell

PubMed ID: 38320549

Doi: 10.1016/j.cell.2024.01.024

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Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis

Authors: Kai Lu , Xinlong Li , Jie Wu

Journal: Immunity

PubMed ID: 38270316

Doi: 10.1002/iid3.1135

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9S1R nullomer peptide induces mitochondrial pathology, metabolic suppression, and enhanced immune cell infiltration, in triple-negative breast cancer mouse model

Authors: Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R Veerabhadraiah, Laura Bond, Matthew W Turner, Cheryl L Jorcyk, Greg Hampikian

Journal: Biomed Pharmacother

PubMed ID: 38118350

Doi: 10.1016/j.biopha.2023.115997.

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Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α

Authors: Zuen Ren, Malindrie Dharmaratne, Huizhi Liang, Outhiriaradjou Benard, Miriam Morales-Gallego, Kimita Suyama, Viney Kumar, Atefeh Taherian Fard, Ameya S Kulkarni, Michael Prystowsky, Jessica C Mar, Larry Norton, Rachel B Hazan

Journal: Br J Cancer

PubMed ID: 38238426

Doi: 10.1038/s41416-023-02522-5

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Revamped mini-αA-crystallin showed improved skin permeation and therapeutic activity against melittin-induced toxicity

Authors: Tenzin Tender, Rakesh Ravishankar Rahangdale, Madhavan Nampoothiri, Ruchira Raychaudhuri, Srinivas Mutalik, Krishna Sharma, Raghu Chandrashekar H

Journal: Toxicon

PubMed ID: 38211805

Doi: 10.1016/j.toxicon.2024.107611

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Surface-modified measles vaccines encoding oligomeric, prefusion-stabilized SARS-CoV-2 spike glycoproteins boost neutralizing antibody responses to Omicron and historical variants, independent of measles seropositivity

Authors: Miguel Á Muñoz-Alía, Rebecca A Nace, Baskar Balakrishnan, Lianwen Zhang, Nandakumar Packiriswamy, Gagandeep Singh, Prajakta Warang, Ignacio Mena, Riya Narjari, Rianna Vandergaast, Kah-Whye Peng, Adolfo García-Sastre, Michael Schotsaert, Stephen J Russell

Journal: MBio

PubMed ID: 38193729

Doi: 10.1128/mbio.02928-23

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Production of recombinant HPV11/16 E6/E7-MBP-His fusion proteins and their potential to induce cytokine secretion by immune cells in peripheral blood

Authors: Mei-Nian Xu, Mei-Zhen Zhong, Si-Ning Feng, Yan-Qin Xu, Xiao-Ming Peng, Kang Zeng, Xiao-Wen Huang

Journal: Virol J

PubMed ID: 38183109

Doi: 10.1186/s12985-023-02281-y

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Development of Moloney Murine Leukemia Virus Reverse Transcriptase Fused with Archaeal DNA-binding Protein Sis7a

Authors: Goldyna M Simanjuntak, Azzania Fibriani, Amalia A Fananda, Nicholas Yamahoki

Journal: Recent Pat Biotechnol

PubMed ID: 37016518

Doi: 10.2174/1872208317666230403104302

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Inactivation mechanism of cold plasma combined with 222 nm ultraviolet for spike protein and its application in disinfecting of SARS-CoV-2

Authors: Xiaowei Sheng, Jin Wang, Luling Zhao, Wenjing Yan, Jing Qian, Zhaobin Wang, Jianhao Zhang, Vijaya Raghavan

Journal: J Hazard Mater

PubMed ID: 38215522

Doi: 10.1016/j.jhazmat.2024.133458

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DOCK4 is a Novel Prognostic Biomarker and Correlated with Immune Infiltrates in Colon Adenocarcinoma

Authors: Xingjiang Xie, Yi Lu, Bo Wang, Xiaobin Yin, Jianfeng Chen

Journal: Comb Chem High Throughput Screen

PubMed ID: 37702239

Doi: 10.2174/1386207326666230912094101

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IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway

Authors: Weifeng Xu, Rui Chao, Xinru Xie, Yi Mao, Xinwei Chen, Xuzhuo Chen, Shanyong Zhang

Journal: Cell Commun Signal

PubMed ID: 38291404

Doi: 10.1186/s12964-023-01423-7

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Cross-species immunoprotective antigens (subolesin, ferritin 2 and P0) provide protection against Rhipicephalus sanguineus sensu lato

Authors: Ismail Zeb, Luís Fernando Parizi, Muhammad Israr, Itabajara da Silva Vaz, Abid Ali

Journal: Parasit Vectors

PubMed ID: 38172894

Doi: 10.1186/s13071-023-06079-3

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Nanobodies as potential tools for microbiological testing of live biotherapeutic products

Authors: Robert J Dorosky, Jeremy E Schreier, Stephanie L Lola, Rosa L Sava, Michael P Coryell, Adovi Akue, Mark KuKuruga, Paul E Carlson, Sheila M Dreher-Lesnick, Scott Stibitz

Journal: AMB Express

PubMed ID: 38245586

Doi: 10.1186/s13568-023-01659-z

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Oral delivery of bacteria expressing wsv108 gene-specific dsRNA protects shrimp from white spot syndrome virus (WSSV) infection

Authors: Linwei Yang, Siyou Huang, Zi-Ang Wang, Deyu Han, Yushi Gan, Ran Geng, Hongliang Zuo, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu

Journal: Int J Biol Macromol

PubMed ID: 38302014

Doi: 10.1016/j.ijbiomac.2024.129840

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Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase

Authors: Marlo K Thompson, Nidhi Sharma, Andrea Thorn, Aishwarya Prakash

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 38289715

Doi: 10.1107/S205979832400038X

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Longitudinal analysis of antibody responses to Plasmodium vivax sporozoite antigens following natural infection

Authors: Pongsakorn Thawornpan, Justin Nicholas, Chayapat Malee, Piyawan Kochayoo, Kittikorn Wangriatisak, Pachara Tianpothong, Francis Babila Ntumngia, Samantha J Barnes, John H Adams, Patchanee Chootong

Journal: PLoS Negl Trop Dis

PubMed ID: 38277340

Doi: 10.1371/journal.pntd.0011907

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Identification and Functional Characterization of Oxidosqualene Cyclases from Medicinal Plant

Authors: Iffat Parveen, Mei Wang, Joseph Lee, Jianping Zhao, Yingjie Zhu, Amar G Chittiboyina, Ikhlas A Khan, Zhiqiang Pan

Journal: Plants (Basel)

PubMed ID: 38256784

Doi: 10.3390/plants13020231

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A dual-functional oncolytic adenovirus ZD55-aPD-L1 scFv armed with PD-L1 inhibitor potentiates its antitumor activity

Authors: Shengsheng Mei, Shanshan Peng, Eu Gene Vong, Jinbiao Zhan

Journal: Int Immunopharmacol

PubMed ID: 38278066

Doi: 10.1016/j.intimp.2024.111579

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Mulberry-derived miR168a downregulates BmMthl1 to promote physical development and fecundity in silkworms

Authors: Lin Chen, Jiubo Liang, Qi Zhang, Chao Yang, Hulin Lu, Renze Zhang, Kaiying Chen, Sheng Wang, Mingbo Li, Shaoyu Zhang, Ningjia He

Journal: Int J Biol Macromol

PubMed ID: 38199542

Doi: 10.1016/j.ijbiomac.2023.129077

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Individual transmembrane domains of SfABCC2 from Spodoptera frugiperda do not serve as functional Cry1F receptors

Authors: Jianfeng Zhong, Rafael Ferreira Dos Santos, Heba Abdelgaffar, Caroline Placidi de Bortoli, Ahmad Raza, Juan Luis Jurat-Fuentes

Journal: Pestic Biochem Physiol

PubMed ID: 38458684

Doi: 10.1016/j.pestbp.2024.105777

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A novel fully human anti-NT-ANGPTL3 antibody from phage display library exhibits potent ApoB, TG, and LDL-C lowering activities in hyperlipidemia mice

Authors: Panpan Zhang, Ke Wang, Tuo Hu, Menglong Xu, Xiangyan You, Manman Chen, Xuan Tang, Huajing Hu, Yiwei Jiang, Wenfeng Zhao, Shuhua Tan

Journal: FASEB J

PubMed ID: 38174870

Doi: 10.1096/fj.202301564RR

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Multivalent Calixarene Complexation of a Designed Pentameric Lectin

Authors: Ronan J Flood, Linda Cerofolini, Marco Fragai, Peter B Crowley

Journal: Biomacromolecules

PubMed ID: 38227741

Doi: 10.1021/acs.biomac.3c01280

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Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Authors: Yehudi Bloch, Jan Felix, Romain Merceron, Mathias Provost, Royan Alipour Symakani, Robin De Backer, Elisabeth Lambert, Ahmad R Mehdipour, Savvas N Savvides

Journal: Nat Struct Mol Biol

PubMed ID: 38287195

Doi: 10.1038/s41594-023-01190-6

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Temporal dynamics of the early immune response following Mycobacterium bovis infection of cattle

Authors: Thomas Holder, Sreenidhi Srinivasan, Adrian McGoldrick, Gareth A Williams, Simonette Palmer, John Clarke, Amanda O'Brien, Andrew J K Conlan, Nick Juleff, H Martin Vordermeier, Gareth J Jones, Vivek Kapur

Journal: Sci Rep

PubMed ID: 38297023

Doi: 10.1038/s41598-024-52314-x

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Design of protein-binding peptides with controlled binding affinity: the case of SARS-CoV-2 receptor binding domain and angiotensin-converting enzyme 2 derived peptides

Authors: Giacomo Parisi, Roberta Piacentini, Alessio Incocciati, Alessandra Bonamore, Alberto Macone, Jakob Rupert, Elsa Zacco, Mattia Miotto, Edoardo Milanetti, Gian Gaetano Tartaglia, Giancarlo Ruocco, Alberto Boffi, Lorenzo Di Rienzo

Journal: Front Mol Biosci

PubMed ID: 38250735

Doi: 10.3389/fmolb.2023.1332359

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Proteome profiling of enriched membrane-associated proteins unraveled a novel sophorose and cello-oligosaccharide transporter in Trichoderma reesei

Authors: Karoline Maria Vieira Nogueira, Vanessa Mendes, Karthik Shantharam Kamath, Anusha Cheruku, Letícia Harumi Oshiquiri, Renato Graciano de Paula, Claudia Carraro, Wellington Ramos Pedersoli, Lucas Matheus Soares Pereira, Luiz Carlos Vieira, Andrei Stecca Steindorff, Ardeshir Amirkhani, Matthew J McKay, Helena Nevalainen, Mark P Molloy, Roberto N Silva

Journal: Microb Cell Fact

PubMed ID: 38229067

Doi: 10.1186/s12934-023-02279-9

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Improved Solubility and Stability of a Thermostable Carbonic Anhydrase via Fusion with Marine-Derived Intrinsically Disordered Solubility Enhancers

Authors:

Journal: Int J Mol Sci

PubMed ID: 38256209

Doi: 10.3390/ijms25021139

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ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis

Authors: Shen Li, Jiangbo Han, Jiongzhe Cao, Hong Han, Bin Lu, Tao Wen, Weiguo Bian

Journal: Environ Toxicol

PubMed ID: 38174997

Doi: 10.1002/tox.24131

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High-titer manufacturing of SARS-CoV-2 Spike-pseudotyped VSV in stirred-tank bioreactors

Authors: Hayley M Todesco, Chris Gafuik, Cini M John, Erin L Roberts, Breanna S Borys, Alexis Pawluk, Michael S Kallos, Kyle G Potts, Douglas J Mahoney

Journal: Mol Ther Methods Clin Dev

PubMed ID: 38327804

Doi: 10.1016/j.omtm.2024.101189

Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome

Authors: Nanyang Liu, Yanqiu Ding, Hao Zhou, Xing Chang, Long Lou

Journal: Int J Med Sci

PubMed ID: 38322592

Doi: 10.7150/ijms.90484

Products & Services: Proteins, Expression, Isolation and Analysis

TLR4 Ligands in Typhoid Vi Polysaccharide Subunit Vaccines Contribute to Immunogenicity

Authors:

Journal: Immunohorizons

PubMed ID: 38180344

Doi: 10.4049/immunohorizons.2300085

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Targeted mutagenesis in mice via an engineered AsCas12f1 system

Authors: Peng Fan, Hejun Wang, Feiyu Zhao, Tao Zhang, Jinze Li, Xiaodi Sun, Yongduo Yu, Haoyang Xiong, Liangxue Lai, Tingting Sui

Journal: Cell Mol Life Sci

PubMed ID: 38280977

Doi: 10.1007/s00018-023-05100-3

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A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells

Authors: Shivakshi Sulekh, Yuko Ikegawa, Saki Naito, Asami Oji, Ichiro Hiratani, Sa Kan Yoo

Journal: Life Sci Alliance

PubMed ID: 38296349

Doi: 10.26508/lsa.202302238

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Clinical assays rapidly predict bacterial susceptibility to monoclonal antibody therapy

Authors: Matthew J Slarve, Neven Bowler, Elizabeth Burk, Jun Yan, Ulrike Carlino-MacDonald, Thomas A Russo, Brian M Luna, Brad Spellberg

Journal: JCI Insight

PubMed ID: 38258902

Doi: 10.1172/jci.insight.174799

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B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure

Authors: Yuting Zhai, Junhong Chen, Rongsheng Kan, Haochen Xuan, Chaofan Wang, Dongye Li, Tongda Xu

Journal: Int Heart J

PubMed ID: 38556337

Doi: 10.1536/ihj.23-144

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Recombinant protein expression in proteome-reduced cells under aerobic and oxygen-limited regimes

Authors: Alvaro R Lara, Jose Utrilla, Luz María Martínez, Niels Krausch, Lucas Kaspersetz, David Hidalgo, Nicolas Cruz-Bournazou, Peter Neubauer, Juan-Carlos Sigala, Guillermo Gosset, Jochen Büchs

Journal: Biotechnol Bioeng

PubMed ID: 38178599

Doi: 10.1002/bit.28645

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Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif

Authors: Wuyang Shi , Shibo Sun , Haowen Liu , Yao Meng , Kangshuai Ren , Guoying Wang , Minghui Liu , Jiaqi Wu , Yue Zhang , Huang Huang , Meiyun Shi , Weiping Xu , Qiang Ma , Bingbing Sun , Jianqiang Xu

Journal: Redox biology

Doi: 10.1016/j.redox.2024.103050

Products & Services: Proteins, Expression, Isolation and Analysis

Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules

Authors: Christopher M. Hickey, Katherine M. Digianantonio, Kurt Zimmermann , Alicia Harbin, Connor Quinn, Avani Patel, Peter Gareiss , Amanda Chapman1 , Bernadette Tiberi1,2, Jennifer Dobrodziej1,3, John Corradi1 , Angela M. Cacace1 , David R. Langley & Miklós Békés

Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY

Doi: 10.1038/s41594-023-01146-w

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The CRISPR effector Cam1 mediates membrane depolarization for phage defence

Authors: Christian F. Baca, You Yu, Jakob T. Rostøl, Puja Majumder, Dinshaw J. Patel & Luciano A. Marraffini

Journal: Nature

PubMed ID: 38200316

Doi: 10.1038/s41586-023-06902-y

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A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction

Authors: Sibei Tang, Junxun Zhang, Fangzhou Lou, Hong Zhou, Xiaojie Cai, Zhikai Wang, Libo Sun, Yang Sun, Xiangxiao Li, Li Fan, Yan Li, Xinping Jin, Siyu Deng, Qianqian Yin, Jing Bai, Hong Wang, Honglin Wang

Journal: EMBO Rep

PubMed ID: 38291338

Doi: 10.1038/s44319-024-00070-4

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Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination

Authors: Fatima Amer-Sarsour, Daniel Falik, Yevgeny Berdichevsky, Alina Kordonsky, Sharbel Eid, Tatiana Rabinski, Hasan Ishtayeh, Stav Cohen-Adiv, Itzhak Braverman, Sergiu C Blumen, Tal Laviv, Gali Prag, Gad D Vatine, Avraham Ashkenazi

Journal: EMBO J

PubMed ID: 38177505

Doi: 10.1038/s44318-023-00018-9

Two Receptor Binding Strategy of SARS-CoV-2 Is Mediated by Both the N-Terminal and Receptor-Binding Spike Domain

Authors: Michele Monti, Edoardo Milanetti, Myrthe T Frans, Mattia Miotto, Lorenzo Di Rienzo, Maksim V Baranov, Giorgio Gosti, Arun Kumar Somavarapu, Madhu Nagaraj, Thaddeus W Golbek, Emiel Rossing, Sam J Moons, Thomas J Boltje, Geert van den Bogaart, Tobias Weidner, Daniel E Otzen, Gian Gaetano Tartaglia, Giancarlo Ruocco, Steven J Roeters

Journal: J Phys Chem B

PubMed ID: 38190651

Doi: 10.1021/acs.jpcb.3c06258

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Complete microbial synthesis of crocetin and crocins from glycerol in Escherichia coli

Authors: Jun Ho Lee, Seong-Rae Lee, Sang Yup Lee, Pyung Cheon Lee

Journal: Microb Cell Fact

PubMed ID: 38178149

Doi: 10.1186/s12934-023-02287-9

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A fast and easy one-step purification strategy for plant-made antibodies using Protein A magnetic beads

Authors: Loïc Faye, Clemens Grünwald-Gruber, Louis-Philippe Vezina, Véronique Gomord, Bertrand Morel

Journal: Front Plant Sci

PubMed ID: 38235198

Doi: 10.3389/fpls.2023.1276148

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Circ_0007422 Knockdown Inhibits Tumor Property and Immune Escape of Colorectal Cancer by Decreasing PDL1 Expression in a miR-1256-Dependent Manner

Authors: Dian Yin, Li Yang, Xiu Feng, Xiaolu Zhai, Mei Hua, Jing Liu, Ying Chen

Journal: Mol Biotechnol

PubMed ID: 38253900

Doi: 10.1007/s12033-023-01040-2

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Structural and functional properties of uridine 5'-monophosphate synthase from Coffea arabica

Authors: Alexis Hinojosa-Cruz, Ángel G Díaz-Sánchez, Adelaida Díaz-Vilchis, Lilian González-Segura

Journal: Int J Biol Macromol

PubMed ID: 38184030

Doi: 10.1016/j.ijbiomac.2024.129226

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Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury

Authors: Ari Kwon, Na Young Lee, Jae-Hyun Yu, Myeung Gi Choi, Jeongwoo Park, Ja Hyun Koo

Journal: Cell Death Dis

PubMed ID: 38225223

Doi: 10.1038/s41419-024-06448-5

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Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

Authors: Jun Wang , Jinyong Huang , Yunlong Hu , Qianwen Guo , Shasha Zhang , Jinglin Tian , Yanqin Niu , Ling Ji , Yuzhong Xu , Peijun Tang , Yaqin He , Yuna Wang , Shuya Zhang , Hao Yang , Kang Kang , Xinchun Chen , Xinying Li , Ming Yang , Deming Gou

Journal: Nat Commun

PubMed ID: 38168054

Doi: 10.1038/s41467-023-44461-y

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The structure of the diheme cytochrome c from Neisseria gonorrhoeae reveals multiple contributors to tuning reduction potentials

Authors: Fangfang Zhong, Morgan E Reik, Michael J Ragusa, Ekaterina V Pletneva

Journal: J Inorg Biochem

PubMed ID: 38330683

Doi: 10.1016/j.jinorgbio.2024.112496

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Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2

Authors: Klara Lenart, Rodrigo Arcoverde Cerveira, Fredrika Hellgren, Sebastian Ols, Daniel J Sheward, Changil Kim, Alberto Cagigi, Matthew Gagne, Brandon Davis, Daritza Germosen, Vicky Roy, Galit Alter, Hélène Letscher, Jérôme Van Wassenhove, Wesley Gros, Anne-Sophie Gallouët, Roger Le Grand, Harry Kleanthous, Mimi Guebre-Xabier, Ben Murrell, Nita Patel, Gregory Glenn, Gale Smith, Karin Loré

Journal: npj Vaccines

PubMed ID: 38245545

Doi: 10.1038/s41541-024-00806-2

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Systematic analysis of the prognostic value and immunological function of LTBR in human cancer

Authors: Yinteng Wu, Shijian Zhao, Wenliang Guo, Ying Liu, Marìa Del Mar Requena Mullor, Raquel Alarcòn Rodrìguez, Ruqiong Wei

Journal: Aging (Albany NY)

PubMed ID: 38175686

Doi: 10.18632/aging.205356

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The Chinese Hamster Ovary Cell-Based H9 HA Subunit Avian Influenza Vaccine Provides Complete Protection against the H9N2 Virus Challenge in Chickens

Authors: Shunfan Zhu, Zhenyu Nie, Ying Che, Jianhong Shu, Sufang Wu, Yulong He, Youqiang Wu, Hong Qian, Huapeng Feng, Qiang Zhang

Journal: Viruses

PubMed ID: 38275973

Doi: 10.3390/v16010163

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Structure of a tripartite protein complex that targets toxins to the type VII secretion system

Authors: Timothy A Klein, Prakhar Y Shah, Polyniki Gkragkopoulou, Dirk W Grebenc, Youngchang Kim, John C Whitney

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38194450

Doi: 10.1073/pnas.2312455121

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Orthopoxvirus-Specific T-Cell Responses in Convalescent Mpox Patients

Authors: Caroline C Traut, Joyce L Jones, Renata A Sanders, Laura R Clark, Matthew M Hamill, Georgia Stavrakis, Joel Sop, Tyler P Beckey, Sara C Keller, Elizabeth A Gilliams, Willa V Cochran, Oliver Laeyendecker, Yukari C Manabe, Heba H Mostafa, David L Thomas, Bhakti Hansoti, Kelly A Gebo, Joel N Blankson

Journal: J Infect Dis

PubMed ID: 37380166

Doi: 10.1093/infdis/jiad245

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Influenza a Neuraminidase-Based Bivalent mRNA Vaccine Induces Th1-Type Immune Response and Provides Protective Effects in Mice

Authors: Mingyang Li , Mengyuan Liu , Shaohui Song, Ruirui Zhao, Yun Xie, Jing Liu, Lilan Xu, Xuefeng Ma, Mingyu Song, Jian Zhou and Guoyang Liao

Journal: vaccine

Doi: 10.3390/vaccines12030300

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Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs

Authors: Yingli Zhu, Thibaut Burg, Katrien Neyrinck, Tim Vervliet, Fatemeharefeh Nami, Ellen Vervoort, Karan Ahuja, Maria Livia Sassano, Yoke Chin Chai, Arun Kumar Tharkeshwar, Jonathan De Smedt, Haibo Hu, Geert Bultynck, Patrizia Agostinis, Johannes V. Swinnen, Ludo Van Den Bosch, Rodrigo Furtado Madeiro da Costa & Catherine Verfaillie

Journal: Acta Neuropathologica

PubMed ID: 38395965

Doi: 10.1007/s00401-023-02666-x

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LATS2 condensates organize signalosomes for Hippo pathway signal transduction

Authors: Min Qin, Ershuo Geng, Jingning Wang, Man Yu, Tianqi Dong, Shasha Li, Xiao Zhang, Jiaming Lin, Mingjun Shi, Juebei Li, Huixia Zhang, Lian Chen, Xiaolei Cao, Liu Huang, Mingwei Wang, Yan Li, Xiang-ping Yang, Bin Zhao & Shuguo Sun

Journal: Nature Chemical Biology

PubMed ID: 38200110

Doi: 10.1038/s41589-023-01516-x

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Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use

Authors: Anna Worthmann , Julius Ridder , Sharlaine Y L Piel , Ioannis Evangelakos , Melina Musfeldt , Hannah Voß , Marie O'Farrell , Alexander W Fischer , Sangeeta Adak , Monica Sundd , Hasibullah Siffeti , Friederike Haumann , Katja Kloth , Tatjana Bierhals , Markus Heine , Paul Pertzborn , Mira Pauly , Julia-Josefine Scholz , Suman Kundu , Marceline M Fuh , Axel Neu , Klaus Tödter , Maja Hempel , Uwe Knippschild , Clay F Semenkovich , Hartmut Schlüter , Joerg Heeren , Ludger Scheja , Christian Kubisch , Christian Schlein

Journal: Nat Commun

PubMed ID: 38167725

Doi: 10.1038/s41467-023-44364-y

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Rif2 interaction with Rad50 counteracts Tel1 functions in checkpoint signalling and DNA tethering by releasing Tel1 from MRX binding

Authors: Paolo Pizzul, Erika Casari, Carlo Rinaldi, Marco Gnugnoli, Marco Mangiagalli, Renata Tisi, Maria Pia Longhese

Journal: Nucleic Acids Res

PubMed ID: 38180815

Doi: 10.1093/nar/gkad1246

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A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease

Authors: Su-Jeong Kim, Brendan Miller, Nicolas G Hartel, Ricardo Ramirez, Regina Gonzalez Braniff, Naphada Leelaprachakul, Amy Huang, Yuzhu Wang, Thalida Em Arpawong, Eileen M Crimmins, Penglong Wang, Xianbang Sun, Chunyu Liu, Daniel Levy, Kelvin Yen, Giselle M Petzinger, Nicholas A Graham, Michael W Jakowec, Pinchas Cohen

Journal: Mol Psychiatry

PubMed ID: 38167865

Doi: 10.1038/s41380-023-02344-0

Products & Services: Peptide Synthesis

Leafhopper salivary vitellogenin mediates virus transmission to plant phloem

Authors: Yanfei Wang , Chengcong Lu , Shude Guo , Yuxin Guo , Taiyun Wei , Qian Chen

Journal: Nat Commun

PubMed ID: 38167823

Doi: 10.1038/s41467-023-43488-5

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Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1-Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

Authors: Andrew V Oleinikov, Zakaria Seidu, Irina V Oleinikov, Mary Tetteh, Helena Lamptey, Michael F Ofori, Lars Hviid, Mary Lopez-Perez

Journal: J Infect Dis

PubMed ID: 37804095

Doi: 10.1093/infdis/jiad438

Products & Services: Proteins, Expression, Isolation and Analysis

Cdk5-dependent rapid formation and stabilization of dendritic spines by corticotropin-releasing factor

Authors: Dorien Vandael, Katlijn Vints, Pieter Baatsen, Małgorzata A Śliwińska, Sergio Gabarre, Lies De Groef, Lieve Moons, Vasily Rybakin, Natalia V Gounko

Journal: Transl Psychiatry

PubMed ID: 38233378

Doi: 10.1038/s41398-024-02749-7

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Authors: Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza

Journal: Pharmaceutics

PubMed ID: 38258126

Doi: 10.3390/pharmaceutics16010116

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Restricted Omicron-specific cross-variant memory B-cell immunity after a 3rd dose/booster of monovalent Wuhan-Hu-1-containing COVID-19 mRNA vaccine

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Nathaniel D Warner, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: Vaccine

PubMed ID: 38233288

Doi: 10.1016/j.vaccine.2024.01.032

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Phylogenetic conservation of Trop-2 across species-rodent and primate genomics model anti-Trop-2 therapy for pre-clinical benchmarks

Authors: Emanuela Guerra, Marco Trerotola, Valeria Relli, Rossano Lattanzio, Khouloud Boujnah, Nicole Travali, Antonino Moschella, Paolo Todaro, Laura Pierdomenico, Roberta Di Pietro, Nicola Tinari, Saverio Alberti

Journal: Front Genet

PubMed ID: 38250577

Doi: 10.3389/fgene.2023.1297367

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Construction and characterization of a humanized rat model with its application in evaluating the uptake of different statins

Authors: Yuanjin Zhang, Junze Huang, Shengbo Huang, Jie Liu, Luyao Deng, Chenmeizi Liang, Yuanqing Guo, Bingyi Yao, Xin Wang

Journal: Acta Pharm Sin B

PubMed ID: 38572097

Doi: 10.1016/j.apsb.2023.12.019

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Synthesis and mechanistic study of ultrashort peptides that inhibits Alzheimer's Aβ-aggregation-induced neurotoxicity

Authors: Naina Sehra, Rajesh Parmar, Indresh K Maurya, Vinod Kumar, Kulbhushan Tikoo, Rahul Jain

Journal: Bioorg Chem

PubMed ID: 38309001

Doi: 10.1016/j.bioorg.2024.107159

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LINC00662 promotes melanoma progression by competitively binding miR-107 and activating the β-catenin signaling pathway

Authors: Mengmeng Luo, Rui Lei, Qingfang Zhao, Yichen Shen, Zhigang He, Jinghong Xu

Journal: Int J Med Sci

PubMed ID: 38169586

Doi: 10.7150/ijms.84072

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Precise coordination between nutrient transporters ensures fertility in the malaria mosquito Anopheles gambiae

Authors: Iryna Stryapunina, Maurice A Itoe, Queenie Trinh, Charles Vidoudez, Esrah Du, Lydia Mendoza, Oleksandr Hulai, Jamie Kauffman, John Carew, W Robert Shaw, Flaminia Catteruccia

Journal: PLoS Genet

PubMed ID: 38285728

Doi: 10.1371/journal.pgen.1011145

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Delivery of mRNA with Histidine-Lysine Peptides

Authors: Qixin Leng, Jiaxi He, Aishwarya Anand, A James Mixson

Journal: Methods Mol Biol

PubMed ID: 38907929

Doi: 10.1007/978-1-0716-3918-4_23

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Jianpi Antai formula prevents miscarriage by repressing M1 polarization of decidual macrophages through ubiquitination of NLRP3 mediated by MARCH7

Authors: Ying Zhao, Chenyun Miao, Ruye Wang, Yun Chen, Ning Ren, Jing Ma, Tao Gao, Qin Zhang

Journal: J Ethnopharmacol

PubMed ID: 38246482

Doi: 10.1016/j.jep.2024.117796

Products & Services: Proteins, Expression, Isolation and Analysis

Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production

Authors: Sri Harsha Adusumilli, Anuthariq Alikkam Veetil, Chinmayee Choudhury, Banani Chattopadhyaya, Diptimayee Behera, Anand Kumar Bachhawat

Journal: FEBS Open Bio

PubMed ID: 38124687

Doi: 10.1002/2211-5463.13755

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Polysaccharides Produced by Plant Growth-Promoting Rhizobacteria Strain sp BK01 Enhance Salt Stress Tolerance to

Authors: Enni Chen, Changsheng Yang, Weiyi Tao, Shuang Li

Journal: Polymers (Basel)

PubMed ID: 38201810

Doi: 10.3390/polym16010145

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High-Yield Lasso Peptide Production in a Bacterial Host by Plasmid Copy Number Engineering

Authors: Hannah N Fernandez, Ashley M Kretsch, Sylvia Kunakom, Adjo E Kadjo, Douglas A Mitchell, Alessandra S Eustáquio

Journal: ACS Synth Biol

PubMed ID: 38194362

Doi: 10.1021/acssynbio.3c00597

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Neutrophil-mediated type IV collagen degradation is elevated in patients with mild endoscopic ulcerative colitis reflecting early mucosal destruction

Authors: Marta S Alexdottir, Martin Pehrsson, Viktor Domislovic, Line E Godskesen, Aleksander Krag, Jens Kjeldsen, Marko Brinar, Ana Barisic, Anne-Christine Bay-Jensen, Morten A Karsdal, Zeljko Krznaric, Joachim H Mortensen

Journal: Sci Rep

PubMed ID: 38238446

Doi: 10.1038/s41598-024-52208-y

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TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation

Authors: Xue Hao, Bo Zhao, Martina Towers, Liping Liao, Edgar Luzete Monteiro, Xin Xu, Christina Freeman, Hongzhuang Peng, Hsin-Yao Tang, Aaron Havas, Andrew V Kossenkov, Shelley L Berger, Peter D Adams, David W Speicher, David Schultz, Ronen Marmorstein, Kenneth S Zaret, Rugang Zhang

Journal: Nat Aging

PubMed ID: 38267705

Doi: 10.1038/s43587-023-00564-1

Products & Services: Mutant Libraries

LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL

Authors: Nadine Weinelt, Kaja Nicole Wächtershäuser, Gulustan Celik, Birte Jeiler, Isabelle Gollin, Laura Zein, Sonja Smith, Geoffroy Andrieux, Tonmoy Das, Jens Roedig, Leonard Feist, Björn Rotter, Melanie Boerries, Francesco Pampaloni, Sjoerd J L van Wijk

Journal: Cell Death Dis

PubMed ID: 38245534

Doi: 10.1038/s41419-024-06447-6

Combined Immunoinformatics to Design and Evaluate a Multi-Epitope Vaccine Candidate against Infection

Authors: Song Liang, Shidan Zhang, Yinli Bao, Yumin Zhang, Xinyi Liu, Huochun Yao, Guangjin Liu

Journal: Vaccines (Basel)

PubMed ID: 38400121

Doi: 10.3390/vaccines12020137

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Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar ()

Authors: Paolo Valentini, Srinivas Akula, Abigail Alvarado-Vazquez, Jenny Hallgren, Zhirong Fu, Brett Racicot, Ingo Braasch, Michael Thorpe, Lars Hellman

Journal: Int J Mol Sci

PubMed ID: 38338947

Doi: 10.3390/ijms25031669

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USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication

Authors: Hannah L Mackay, Helen R Stone, Katherine Ellis, George E Ronson, Alexandra K Walker, Katarzyna Starowicz, Alexander J Garvin, Patrick van Eijk, Alina Vaitsiankova, Sobana Vijayendran, James F Beesley, Eva Petermann, Eric J Brown, Ruth M Densham, Simon H Reed, Felix Dobbs, Marco Saponaro, Joanna R Morris

Journal: biorxiv

PubMed ID: 38260523

Doi: 10.1101/2024.01.10.574674

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PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

Authors: Nagaraja Chappidi 1, Thomas Quail 2, Simon Doll 3, Laura T Vogel 4, Radoslav Aleksandrov 5, Suren Felekyan 4, Ralf Kühnemuth 4, Stoyno Stoynov 5, Claus A M Seidel 4, Jan Brugués 6, Marcus Jahnel 3, Titus M Franzmann 1, Simon Alberti

Journal: Cell

PubMed ID: 38320550

Doi: 10.1016/j.cell.2024.01.015

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Structure basis for recognition of plant Rpn10 by phytoplasma SAP05 in ubiquitin-independent protein degradation

Authors: Liying Zhang, Yunxiang Du, Qian Qu, Qingyun Zheng

Journal: iScience

PubMed ID: 38322988

Doi: 10.1016/j.isci.2024.108892

Products & Services: Proteins, Expression, Isolation and Analysis

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Authors: Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Michael L Nosella, Hongshan Zhang, T Reid Alderson, Morgan Dasovich, Anthony Leung, Ilya J Finkelstein, Julie D Forman-Kay, Hyun O Lee

Journal: biorxiv

PubMed ID: 38328070

Doi: 10.1101/2024.01.20.575817

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CFL1 restores the migratory capacity of bone marrow mesenchymal stem cells in primary Sjögren's syndrome by regulating CCR1 expression

Authors: Mengxi Huang, Panpan Zhou, Yang Hang, Dan Wu, Nan Zhao, Genhong Yao, Xiaojun Tang, Lingyun Sun

Journal: Int Immunopharmacol

PubMed ID: 38183912

Doi: 10.1016/j.intimp.2024.111485

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A novel opsonic eCIRP inhibitor for lethal sepsis

Authors: Colleen P Nofi, Chuyi Tan, Gaifeng Ma, Molly Kobritz, Jose M Prince, Haichao Wang, Monowar Aziz, Ping Wang

Journal: J Leukoc Biol

PubMed ID: 37774691

Doi: 10.1093/jleuko/qiad119

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A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathy

Authors: Maryamsadat Seyedsadr, Madison Bang, Ethan McCarthy, Shirley Zhang, Ho-Chung Chen, Mahnia Mohebbi, Willy Hugo, Jason K Whitmire, Melissa G Lechner, Maureen A Su

Journal: biorxiv

PubMed ID: 38260637

Doi: 10.1101/2024.01.07.574553

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Molecular mechanisms and evolutionary robustness of a color switch in proteorhodopsins

Authors: Jiafei Mao, Xinsheng Jin, Man Shi, David Heidenreich, Lynda J Brown, Richard C D Brown, Moreno Lelli, Xiao He, Clemens Glaubitz

Journal: Sci Adv

PubMed ID: 38266078

Doi: 10.1126/sciadv.adj0384

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Enantioselective Toxicity and Potential Endocrine-Disruptive Effects of the Insecticides Flufiprole and Ethiprole on

Authors: Lianshan Li, Xuejun Zhao, Kunming Hu, Weiye Xu, Minghua Wang, Hongjie Wang

Journal: J Agric Food Chem

PubMed ID: 38190123

Doi: 10.1021/acs.jafc.3c07896

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An inoculation site-retained mRNA vaccine induces robust immune responses against SARS-CoV-2 variants

Authors: Lei Huang, Fanfan Zhao, Muye He, Yi Fang, Xiaoping Ma, Shuaiyao Lu, Entao Li, Hui Xiao, Hanfei Zhu, Xueli Wang, Siyuan Tang, Bo Yu, Jie Wang, Dong Zhao, Chao Wang, Hangwen Li, Yuwei Gao, Xiaozhong Peng, Haifa Shen

Journal: J Control Release

PubMed ID: 38184234

Doi: 10.1016/j.jconrel.2024.01.002

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Herpes simplex virus type 1 modifies the protein composition of extracellular vesicles to promote neurite outgrowth and neuroinfection

Authors: Guorong Sun, Kai Alexander Kropp, Marieluise Kirchner, Nina Plückebaum, Anton Selich, Manutea Serrero, Akshay Dhingra, Jorge Rubén Cabrera, Birgit Ritter, Rudolf Bauerfeind, Emanuel Wyler, Markus Landthaler, Axel Schambach, Beate Sodeik, Philipp Mertins, Abel Viejo-Borbolla

Journal: MBio

PubMed ID: 38275838

Doi: 10.1128/mbio.03308-23

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PlzA is a cyclic-di-GMP dependent DNA and RNA binding protein

Authors: Nerina Jusufovic, Andrew C Krusenstjerna, Christina R Savage, Timothy C Saylor, Catherine A Brissette, Wolfram R Zückert, Paula J Schlax, Md A Motaleb, Brian Stevenson

Journal: biorxiv

PubMed ID: 36778503

Doi: 10.1101/2023.01.30.526351

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Material assembly from collective action of shape-changing polymers

Authors: Mustafa K Abdelrahman, Robert J Wagner, Manivannan Sivaperuman Kalairaj, Mason Zadan, Min Hee Kim, Lindy K Jang, Suitu Wang, Mahjabeen Javed, Asaf Dana, Kanwar Abhay Singh, Sarah E Hargett, Akhilesh K Gaharwar, Carmel Majidi, Franck J Vernerey, Taylor H Ware

Journal: Nat Mater

PubMed ID: 38177377

Doi: 10.1038/s41563-023-01761-4

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Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer's Disease

Authors: Song-I Seol, Dashdulam Davaanyam, Sang-A Oh, Eun-Hwa Lee, Pyung-Lim Han, Seung-Woo Kim, Ja-Kyeong Lee

Journal: Cells

PubMed ID: 38247880

Doi: 10.3390/cells13020189

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Knock-in mutagenesis in Drosophila Rdl underscores the critical role of the conserved M3 glycine in mediating the actions of broflanilide and isocycloseram on GABA receptors

Authors: Yoshihisa Ozoe, Toshifumi Nakao, Shu Kondo, Yasuhide Yoshioka, Fumiyo Ozoe, Shinichi Banba

Journal: Pestic Biochem Physiol

PubMed ID: 38458683

Doi: 10.1016/j.pestbp.2024.105776

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Screening and Identification of Anti-Idiotypic Nanobody Capable of Broad-Spectrum Recognition of the Toxin Binding Region of Lepidopteran Cadherins and Mimicking Domain II of Cry2Aa Toxin

Authors: Cheng Shen, Jiafeng Jin, Ziyan Huang, Meng Meng, Manman Lin, Xiaodan Hu, Qing Zhu, Chongxin Xu, Wei Chen, Johnson Lin, Xiao Zhang, Yuan Liu, Xianjin Liu

Journal: J Agric Food Chem

PubMed ID: 38221880

Doi: 10.1021/acs.jafc.3c07295

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