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Structural role of K224 in taniborbactam inhibition of NDM-1

Authors: Daisuke Ono, Maria F Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego M Moreno, Alejandro J Vila, Robert A Bonomo

Journal: Antimicrob Agents Chemother

PubMed ID: 38174924

Doi: 10.1128/aac.01332-23

Products & Services: Molecular Biology Reagents

Long chain capsaicin analogues synthetized by CALB-CLEAs show cytotoxicity on glioblastoma cell lines

Authors: Tania Diaz-Vidal, Vicente Paúl Armenta-Pérez, Luis Carlos Rosales-Rivera, Georgina Cristina Basulto-Padilla, Raúl Balam Martínez-Pérez, Juan Carlos Mateos-Díaz, Yanet K Gutiérrez-Mercado, Alejandro A Canales-Aguirre, Jorge A Rodríguez

Journal: Appl Microbiol Biotechnol

PubMed ID: 38217255

Doi: 10.1007/s00253-023-12856-y

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Irreversible light-activated SpyLigation mediates split-protein assembly in 4D

Authors: Brizzia G Munoz-Robles, Cole A DeForest

Journal: Nat Protoc

PubMed ID: 38253657

Doi: 10.1038/s41596-023-00938-0

Products & Services: Proteins, Expression, Isolation and Analysis

Endolysin NC5 improves early cloxacillin treatment in a mouse model of Streptococcus uberis mastitis

Authors: Niels Vander Elst, Julie Bellemans, Rob Lavigne, Yves Briers, Evelyne Meyer

Journal: Appl Microbiol Biotechnol

PubMed ID: 38204128

Doi: 10.1007/s00253-023-12820-w

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The adc1 knockout with proC overexpression in Synechocystis sp PCC 6803 induces a diversion of acetyl-CoA to produce more polyhydroxybutyrate

Authors: Suthira Utharn, Saowarath Jantaro

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 38218963

Doi: 10.1186/s13068-024-02458-9

Products & Services: Proteins, Expression, Isolation and Analysis

Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells

Authors: Hui Wang, Min Tang, Erli Pei, Ying Shen, Aili Wang, Moubin Lin

Journal: Int J Biochem Cell Biol

PubMed ID: 38219975

Doi: 10.1016/j.biocel.2024.106516

Products & Services: Proteins, Expression, Isolation and Analysis

Affinity-assisted covalent self-assembly of PduQ-SpyTag and Nox-SpyCatcher to construct multi-enzyme complexes on the surface of magnetic microsphere modified with chelated Ni

Authors: Mianxing Luo, Meng Zhang, Changbiao Chi, Guo Chen

Journal: Int J Biol Macromol

PubMed ID: 38218263

Doi: 10.1016/j.ijbiomac.2024.129365

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TMEM219 regulates the transcription factor expression and proliferation of beta cells

Authors: Francesca D'Addio, Emma Assi, Anna Maestroni, Giada Rossi, Vera Usuelli, Adriana Petrazzuolo, Marta Nardini, Cristian Loretelli, Moufida Ben Nasr, Paolo Fiorina

Journal: Front Endocrinol (Lausanne)

PubMed ID: 38318298

Doi: 10.3389/fendo.2024.1306127

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Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity

Authors: Ying Meng, Iredia D Iyamu, Noha A M Ahmed, Rong Huang

Journal: ACS Chem Biol

PubMed ID: 38181447

Doi: 10.1021/acschembio.3c00531

Products & Services: Proteins, Expression, Isolation and Analysis

Lipopolysaccharides from a Shiraia fruiting body-associated bacterium elicit host fungal hypocrellin A biosynthesis through nitric oxide generation

Authors: Xin Ping Li , Wen Hao Shen , Lu Lu Zhou , Qun Yan Huang , Rui Peng Cong , Li Ping Zheng , Jian Wen Wang

Journal: Carbohydr Polym .

PubMed ID: 37985049

Doi: 10.1016/j.carbpol.2023.121498.

Products & Services: Proteins, Expression, Isolation and Analysis

Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes

Authors: Zebin Tong , Huasong Ai, Ziyu Xu , Kezhang He , Guo-Chao Chu, Qiang Shi , Zhiheng Deng, Qiaomei Xue , Maoshen Sun, Yunxiang Du , Lujun Liang, Jia-Bin Li , Man Pan , Lei Liu

Journal: Nat Struct Mol Biol .

PubMed ID: 38177667

Doi: 10.1038/s41594-023-01141-1

Products & Services: Proteins, Expression, Isolation and Analysis Gene Synthesis

Inhaled nanoparticles for treating idiopathic pulmonary fibrosis by inhibiting honeycomb cyst and alveoli interstitium remodeling

Authors: Meng-Meng Han , Ling Tang , Bin Huang , Xue-Na Li , Yue-Fei Fang , Liang Qi , Bo-Wen Duan , Ya-Ting Yao , Yu-Jing He , Lei Xing , Hu-Lin Jiang

Journal: J Control Release .

PubMed ID: 38242209

Doi: 10.1016/j.jconrel.2024.01.032

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Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation

Authors: Anlan Yang , Shengjie Liu , Yuqi Zhang , Jia Chen , Yujing Fan , Fengxiang Wang , Yilong Zou , Shan Feng , Jianping Wu , Qi Hu

Journal: Nat Struct Mol Biol .

PubMed ID: 38182928

Doi: 10.1038/s41594-023-01183-5

Products & Services: Proteins, Expression, Isolation and Analysis

Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners

Authors: Pankaj Sharma, Elena Maklashina, Markus Voehler, Sona Balintova , Sarka Dvorakova, Michal Kraus, Katerina Hadrava Vanova Zuzana Nahacka, Renata Zobalova, Stepana Boukalova, Kristyna Cunatova, Tomas Mracek, Hans K Ghayee, Karel Pacak, Jakub Rohlena, Jiri Neuzil, Gary Cecchini,T M Iverson

Journal: Nat Commun

PubMed ID: 38212624

Doi: 10.1038/s41467-023-44563-7

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MARS an improved de novo peptide candidate selection method for non-canonical antigen target discovery in cancer

Authors: Hanqing Liao , Carolina Barra , Zhicheng Zhou , Xu Peng , Isaac Woodhouse , Arun Tailor , Robert Parker , Alexia Carré , Persephone Borrow , Michael J Hogan , Wayne Paes , Laurence C Eisenlohr , Roberto Mallone , Morten Nielsen , Nicola Ternette

Journal: Nat Commun

PubMed ID: 38253617

Doi: 10.1038/s41467-023-44460-z

Products & Services: Peptide Synthesis

The role of CD38 in inflammation-induced depression-like behavior and the antidepressant effect of (R)-ketamine

Authors: Xinying Zhang a , Teng He a , Zifeng Wu a , Yuanyuan Wang a, Hanyu Liu a, Bingyuan Zhang a, Siqi Yang a, Di Wang a, Chaoli Huang a, Jiahao Duan b, Xiangyang Xu c, Xiangqing Xu c, Kenji Hashimoto d, Riyue Jiang e, Ling Yang b, Chun Yang

Journal: Brain, behavior, and immunity

PubMed ID: 37793489

Doi: 10.1016/j.bbi.2023.09.026

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Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites

Authors: Bingsen Zhang, James Mullmann, Andreas H. Ludewig, Irma R. Fernandez, Tyler R. Bales, Robert S. Weiss & Frank C. Schroeder

Journal: Nature Chemical Biology

PubMed ID: 38167917

Doi: 10.1038/s41589-023-01511-2

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Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue

Authors: Guoli Shi , Tiansheng Li , Kin Kui Lai , Reed F Johnson , Jonathan W Yewdell , Alex A Compton

Journal: Nat Commun

PubMed ID: 38291024

Doi: 10.1038/s41467-024-45075-8

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The role of the Toll like receptor 4 signaling in sex-specific persistency of depression-like behavior in response to chronic stress

Authors: Eun-Jeong Yang , Tal Frolinger , Umar Iqbal , Molly Estill , Li Shen , Kyle J Trageser , Giulio M Pasinetti

Journal: Brain, behavior, and immunity

PubMed ID: 37838079

Doi: 10.1016/j.bbi.2023.10.006

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Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells

Authors: Seungwon Jung , Seung Hwan Ko , Narae Ahn , Jinsam Lee , Chang-Hwan Park , Jungwook Hwang

Journal: Nat Commun

PubMed ID: 38167913

Doi: 10.1038/s41467-023-44600-5

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Circ_0087199 depletion attenuates lipopolysaccharides-induced human periodontal ligament cell injury through the miR-527/TLR4 axis

Authors: Jing Wang , Na Huo , Chuan Cai , Yu Zhang, Rui Xiao

Journal: Immunity

PubMed ID: 38270303

Doi: 10.1002/iid3.1153

CI:Mor interactions in the lysogeny switches of TP901-1 and φ13 bacteriophages

Authors: Anders K Varming, Zhiyu Huang, Ghofran M Hamad, Kim K Rasmussen, Hanne Ingmer, Mogens Kilstrup, Leila Lo Leggio

Journal: Microbiome Res Rep

PubMed ID: 38841409

Doi: 10.20517/mrr.2023.50

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IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway

Authors: Zhaojun Liu, Chungang Feng, Chengyu Li, Tong He, Gang Wu, Chen Fu, Hongmin Li, Ming Shen, Honglin Liu

Journal: FASEB J

PubMed ID: 38095232

Doi: 10.1096/fj.202301464R

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering of Ogataea polymorpha strains with ability for high-temperature alcoholic fermentation of cellobiose

Authors: Roksolana Vasylyshyn, Olena Dmytruk, Andriy Sybirnyy, Justyna Ruchała

Journal: FEMS Yeast Res

PubMed ID: 38400543

Doi: 10.1093/femsyr/foae007

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FLUAV RAM-IGIP: A modified live influenza virus vaccine that enhances humoral and mucosal responses against influenza

Authors: C Joaquín Cáceres, L Claire Gay, Aarti Jain, Teresa D Mejías, Matias Cardenas, Brittany Seibert, Flavio Cargnin Faccin, Brianna Cowan, Ginger Geiger, Amy Vincent Baker, Silvia Carnaccini, D Huw Davies, Daniela S Rajao, Daniel R Perez

Journal: biorxiv

PubMed ID: 38328128

Doi: 10.1101/2024.01.23.576908

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Assessment of the effectiveness of the peptide inhibitor homologous to the transforming growth factor β cytokine blocking the TGFβRI/TGFβRII receptor complex-pilot study

Authors: Marynowski Mateusz, Karbownik Michał Seweryn, Szemraj Janusz, Kuna Piotr, Michał Gabriel Panek

Journal: Clin Transl Allergy

PubMed ID: 38282199

Doi: 10.1002/clt2.12320

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Cell death induced by nicotine in human neuroblastoma SH-SY5Y cells is mainly attributed to cytoplasmic vacuolation originating from the trans-Golgi network

Authors: Jun Li, Hongjuan Wang, Huan Chen, Xiao Li, Yong Liu, Hongwei Hou, Qingyuan Hu

Journal: Food Chem Toxicol

PubMed ID: 38176581

Doi: 10.1016/j.fct.2023.114431

Products & Services: Proteins, Expression, Isolation and Analysis

FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors

Authors: Hsin-Fang Tu, Yu-Jui Kung, Ling Lim, Julia Tao, Ming-Hung Hu, Michelle Cheng, Deyin Xing, T C Wu, Chien-Fu Hung

Journal: J Biomed Sci

PubMed ID: 38287325

Doi: 10.1186/s12929-024-01006-9

Products & Services: PCR Cloning and Subcloning

Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases

Authors: Yi Lien, Jake C Lachowicz, Aigera Mendauletova, Cynthia Zizola, Thacien Ngendahimana, Anastasiia Kostenko, Sandra S Eaton, John A Latham, Tyler L Grove

Journal: ACS Chem Biol

PubMed ID: 38295270

Doi: 10.1021/acschembio.3c00583

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Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells

Authors: Gabor Tax, Kevin P Guay, Ludovica Pantalone, Martina Ceci, Tatiana Soldà, Charlie J Hitchman, Johan C Hill, Snežana Vasiljević, Andrea Lia, Carlos P Modenutti, Kees R Straatman, Angelo Santino, Maurizio Molinari, Nicole Zitzmann, Daniel N Hebert, Pietro Roversi, Marco Trerotola

Journal: Traffic

PubMed ID: 38272446

Doi: 10.1111/tra.12927

Products & Services: Mutagenesis Services

GhUBC10-2 mediates GhGSTU17 degradation to regulate salt tolerance in cotton (Gossypium hirsutum)

Authors: Yaru Sun, Zailong Tian, Dongyun Zuo, Qiaolian Wang, Guoli Song

Journal: Plant Cell Environ

PubMed ID: 38282268

Doi: 10.1111/pce.14839

Products & Services: PCR Cloning and Subcloning

factor H-binding proteins are not required for serum resistance and infection in mammals

Authors: Nicholas A Cramer, Kalya M Socarras, Joshua Earl, Garth D Ehrlich, Richard T Marconi

Journal: Infect Immun

PubMed ID: 38289123

Doi: 10.1128/iai.00529-23

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Systemic effects of hypophosphatasia characterization of two novel variants in the gene

Authors: Luis Martínez-Heredia, Manuel Muñoz-Torres, Raquel Sanabria-de la Torre, Ángela Jiménez-Ortas, Francisco Andújar-Vera, Trinidad González-Cejudo, Victoria Contreras-Bolívar, Sheila González-Salvatierra, José María Gómez-Vida, Cristina García-Fontana, Beatriz García-Fontana

Journal: Front Endocrinol (Lausanne)

PubMed ID: 38234425

Doi: 10.3389/fendo.2023.1320516

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Effect of l-serine and magnesium ions on the functional properties of human phosphoserine phosphatase and its pathogenetic variants

Authors: Francesco Marchesani, Valeria Buoli Comani, Stefano Bruno, Andrea Mozzarelli, Mauro Carcelli, Loredano Pollegioni, Laura Caldinelli, Alessio Peracchi, Barbara Campanini

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38278334

Doi: 10.1016/j.bbadis.2024.167034

Products & Services: Mutagenesis Services

Production of anti-human cannabinoid receptor 2 (CB2) monoclonal antibody using non-viral vector induced human CB2 expressing myeloma as an immunogen

Authors: Jindaphun Kanyaruck, Takheaw Nuchjira, Putpim Chaochetdhapada, Laopajon Witida, Kotemul Kamonporn, Chaiwut Ratthakorn, Pata Supansa, Kasinrerk Watchara

Journal: Asian Pac J Allergy Immunol

PubMed ID: 38183645

Doi: 10.12932/AP-020723-1646

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The Anti-SARS-CoV-2 IgG1 and IgG3 Antibody Isotypes with Limited Neutralizing Capacity against Omicron Elicited in a Latin Population a Switch toward IgG4 after Multiple Doses with the mRNA Pfizer-BioNTech Vaccine

Authors: Ana M Espino, Albersy Armina-Rodriguez, Laura Alvarez, Carlimar Ocasio-Malavé, Riseilly Ramos-Nieves, Esteban I Rodriguez Martinó, Paola López-Marte, Esther A Torres, Carlos A Sariol

Journal: Viruses

PubMed ID: 38399963

Doi: 10.3390/v16020187

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BBS genes are involved in accelerated proliferation and early differentiation of BBS-related tissues

Authors: Avital Horwitz, Noa Levi-Carmel, Olga Shnaider, Ruth Birk

Journal: Differentiation

PubMed ID: 38215537

Doi: 10.1016/j.diff.2024.100745

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Cytoophidia Influence Cell Cycle and Size in

Authors: Ruolan Deng, Yi-Lan Li, Ji-Long Liu

Journal: Int J Mol Sci

PubMed ID: 38203781

Doi: 10.3390/ijms25010608

Products & Services: Proteins, Expression, Isolation and Analysis

Functional characterization of the dimeric form of PDGF-derived fusion peptide fabricated based on theoretical arguments

Authors: Maryam Sadeghi-Ardebili, Sadegh Hasannia, Bahareh Dabirmanesh, Ramazan Ali Khavari-Nejad

Journal: Sci Rep

PubMed ID: 38200288

Doi: 10.1038/s41598-024-51707-2

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A small-molecule activation mechanism that directly opens the KCNQ2 channel

Authors: Shaoying Zhang, Demin Ma, Kun Wang, Ya Li, Zhenni Yang, Xiaoxiao Li, Junnan Li, Jiangnan He, Lianghe Mei, Yangliang Ye, Zongsheng Chen, Juwen Shen, Panpan Hou, Jiangtao Guo, Qiansen Zhang, Huaiyu Yang

Journal: Nat Chem Biol

PubMed ID: 38167918

Doi: 10.1038/s41589-023-01515-y

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Ewing Sarcoma Related protein 1 recognizes R-loops by binding DNA forks

Authors: Michelle A Lay, Valery F Thompson, Ajibola D Adelakun, Jacob C Schwartz

Journal: biorxiv

PubMed ID: 38293191

Doi: 10.1101/2024.01.20.576463

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A novel strategy for an anti-idiotype vaccine: nanobody mimicking neutralization epitope of porcine circovirus type 2

Authors: Yingying Deng, Yamin Sheng, Guixi Zhang, Yani Sun, Lei Wang, Pinpin Ji, Jiahong Zhu, Gang Wang, Baoyuan Liu, En-Min Zhou, Xuehui Cai, Yabin Tu, Julian A Hiscox, James P Stewart, Yang Mu, Qin Zhao

Journal: J Virol

PubMed ID: 38271227

Doi: 10.1128/jvi.01650-23

Products & Services: Proteins, Expression, Isolation and Analysis

Improved detection sensitivity of anti-PRV variant antibodies through preparation of anti-gB and anti-gE monoclonal antibodies and development of blocking ELISAs

Authors: Zhenyang Guo, Hu Xu, Siyu Zhang, Haonan Kang, Chao Li, Qi Sun, Jing Zhao, Jinhao Li, Guohui Zhou, Qian Wang, Lirun Xiang, Yandong Tang, Huairan Liu, Chaoliang Leng, Tongqing An, Xuehui Cai, Zhijun Tian, Hongliang Zhang, Jinmei Peng

Journal: Int J Biol Macromol

PubMed ID: 38219937

Doi: 10.1016/j.ijbiomac.2024.129425

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ETHYLENE RESPONSE FACTOR 070 inhibits flowering in Pak-choi by indirectly impairing BcLEAFY expression

Authors: Zhanghong Yu , Xiaoshan Chen , Yan Li , Sayyed Hamad Ahmad Shah , Dong Xiao , Jianjun Wang , Xilin Hou , Tongkun Liu , Ying Li

Journal: Plant Physiol .

PubMed ID: 38269601

Doi: 10.1093/plphys/kiae021

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A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways

Authors: Zhibin Zhang , Xi Lin , Ling Wei , Yiran Wu , Lu Xu , Lijie Wu , Xiaohu Wei , Suwen Zhao, Xiangjia Zhu , Fei Xu

Journal: Cell Discov .

PubMed ID: 38182578

Doi: s41421-023-00627-y

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LL‐37_Renalexin hybrid peptide exhibits antimicrobial activity at lower MICs than its counterpart single peptides

Authors: Julius Kwesi Narh , Nestor G Casillas-Vega , Xristo Zarate

Journal: Appl Microbiol Biotechnol .

PubMed ID: 38229302

Doi: 10.1007/s00253-023-12887-5

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High-Yield Expression and Purification of Scygonadin, an Antimicrobial Peptide, Using the Small Metal-Binding Protein SmbP

Authors: Jessica J. Gomez-Lugo 1 , Nestor G. Casillas-Vega , Alma Gomez-Loredo , Isaias Balderas-Renteria and Xristo Zarate

Journal: Microorganisms

Doi: 10.3390/microorganisms12020278

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Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain

Authors: Yanqun Wang, Zhaoyong Zhang, Minnan Yang, Xinyi Xiong, Qihong Yan, Lei Cao, Peilan Wei, Yuting Zhang, Lu Zhang, Kexin Lv, Jiantao Chen, Xuesong Liu, Xiaochu Zhao, Juxue Xiao, Shengnan Zhang, Airu Zhu, Mian Gan, Jingjun Zhang, Ruoxi Cai, Jianfen Zhuo, Yanjun Zhang, Haiyue Rao, Bin Qu, Yuanyuan Zhang, Lei Chen, Jun Dai, Linling Cheng, Qingtao Hu, Yaoqing Chen, Huibin Lv, Ray T Y So, Malik Peiris, Jingxian Zhao, Xiaoqing Liu, Chris Ka Pun Mok, Xiangxi Wang, Jincun Zhao

Journal: Cell Rep

PubMed ID: 38175758

Doi: 10.1016/j.celrep.2023.113653

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A conserved protein inhibitor brings under check the activity of RNase E in cyanobacteria

Authors: Su-Juan Liu, Gui-Ming Lin, Yu-Qi Yuan, Wenli Chen, Ju-Yuan Zhang, Cheng-Cai Zhang

Journal: Nucleic Acids Res

PubMed ID: 38000383

Doi: 10.1093/nar/gkad1094

Products & Services: Proteins, Expression, Isolation and Analysis

Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice

Authors: Ying-Dan Zhang, Dong-Dong Shi, Bing-Bing Liao, Yi Li, Sen Zhang, Jian Gao, Liang-Jun Lin, Zhen Wang

Journal: Mol Psychiatry

PubMed ID: 38273106

Doi: 10.1038/s41380-024-02424-9

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Pharmacokinetic Analyses of a Lipid Nanoparticle-Encapsulated mRNA-Encoded Antibody against Rift Valley Fever Virus

Authors: Shuo Wang, Ziling Zhu, Jianmin Li

Journal: Mol Pharm

PubMed ID: 38295278

Doi: 10.1021/acs.molpharmaceut.3c01016

Products & Services: Proteins, Expression, Isolation and Analysis

Transition Metal Ion FRET-Based Probe to Study Cu(II)-Mediated Amyloid- Ligand Binding

Authors: Ri Wu, Despoina Svingou, Jonas B Metternich, Lukas R Benzenberg, Renato Zenobi

Journal: J Am Chem Soc

PubMed ID: 38225538

Doi: 10.1021/jacs.3c11533

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Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination

Authors: Autumn E Sanders, Henriette Arnesen, Frances K Shepherd, Dira S Putri, Jessica K Fiege, Mark J Pierson, Shanley N Roach, Harald Carlsen, David Masopust, Preben Boysen, Ryan A Langlois

Journal: mSphere

PubMed ID: 38286428

Doi: 10.1128/msphere.00654-23

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Antibody reactive immunomes of and are diverse and defined by conformational antigenic determinants

Authors: Tian Luo, Jignesh G Patel, Xiaofeng Zhang, Jere W McBride

Journal: Front Cell Infect Microbiol

PubMed ID: 38264730

Doi: 10.3389/fcimb.2023.1321291

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Recombinantly expressed virus-like particles (VLPs) of canine circovirus for development of an indirect ELISA

Authors: Alison Neef, Babu Kanti Nath, Tridip Das, Daniel Luque, Jade K Forwood, Shane R Raidal, Shubhagata Das

Journal: Vet Res Commun

PubMed ID: 38163840

Doi: 10.1007/s11259-023-10290-z

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ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

Authors: Edrees H Rashan, Abigail K Bartlett, Daven B Khana, Jingying Zhang, Raghav Jain, Andrew J Smith, Zakery N Baker, Taylor Cook, Alana Caldwell, Autumn R Chevalier, Brian F Pfleger, Peng Yuan, Daniel Amador-Noguez, Judith A Simcox, David J Pagliarini

Journal: biorxiv

PubMed ID: 38260250

Doi: 10.1101/2024.01.09.574893

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A glycoside hydrolase 30 protein BpXynC of Bacillus paralicheniformis NMSW12 recognized as A MAMP triggers plant immunity response

Authors: Chenjie Yu, Xiaoli Liang, Yan Song, Qurban Ali, Xihao Yang, Linli Zhu, Qin Gu, Vladislav Kuptsov, Emilia Kolomiets, Huijun Wu, Xuewen Gao

Journal: Int J Biol Macromol

PubMed ID: 38286384

Doi: 10.1016/j.ijbiomac.2024.129750

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N-acetyltransferase 10 regulates alphavirus replication via N4- acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA

Authors: Yamei Dang , Jia Li , Yuchang Li , Yuan Wang , Yajing Zhao , Ningbo Zhao , Wanying Li , Hui Zhang , Chuantao Ye , Hongwei Ma , Liang Zhang , He Liu , Yangchao Dong , Min Yao , Yingfeng Lei , Zhikai Xu , Fanglin Zhang , Wei Ye

Journal: J Virol .

PubMed ID: 38169284

Doi: 10.1128/jvi.01350-23

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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Authors: Gisele Nishiguchi , Lauren G Mascibroda , Sarah M Young , Elizabeth A Caine , Sherif Abdelhamed , Jeffrey J Kooijman , Darcie J Miller , Sourav Das , Kevin McGowan , Anand Mayasundari , Zhe Shi , Juan M Barajas , Ryan Hiltenbrand , Anup Aggarwal , Yunchao Chang , Vibhor Mishra , Shilpa Narina , Melvin Thomas , Allister J Loughran , Ravi Kalathur , Kaiwen Yu , Suiping Zhou , Xusheng Wang , Anthony A High , Junmin Peng , Shondra M Pruett-Miller , Danette L Daniels , Marjeta Urh , Anang A Shelat , Charles G Mullighan , Kristin M Riching , Guido J R Zaman , Marcus Fischer , Jeffery M Klco , Zoran Rankovic

Journal: Nat Commun

PubMed ID: 38228616

Doi: 10.1038/s41467-024-44698-1

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Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Authors: Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang , Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao

Journal: Nature

PubMed ID: 37993710

Doi: 10.1038/s41586-023-06753-7

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Structural basis of Gabija anti-phage defence and viral immune evasion

Authors: Sadie P Antine, Alex G Johnson, Sarah E Mooney, Azita Leavitt, Megan L Mayer, Erez Yirmiya, Gil Amitai, Rotem Sorek, Philip J Kranzusch

Journal: Nature

PubMed ID: 37992757

Doi: 10.1038/s41586-023-06855-2

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A synthetic differentiation circuit in Escherichia coli for suppressing mutant takeover

Authors: David S Glass 1, Anat Bren 2, Elizabeth Vaisbourd 2, Avi Mayo 2, Uri Alon

Journal: Cell

PubMed ID: 38320549

Doi: 10.1016/j.cell.2024.01.024

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Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis

Authors: Kai Lu , Xinlong Li , Jie Wu

Journal: Immunity

PubMed ID: 38270316

Doi: 10.1002/iid3.1135

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Molecular Atlas of HER2+ Breast Cancer Cells Treated with Endogenous Ligands: Temporal Insights into Mechanisms of Trastuzumab Resistance

Authors: Kavitha Mukund, Jackelyn A Alva-Ornelas, Adam L Maddox, Divya Murali, Darya Veraksa, Andras Saftics, Jerneja Tomsic, David Frankhouser, Meagan Razo, Tijana Jovanovic-Talisman, Victoria L Seewaldt, Shankar Subramaniam

Journal: Cancers (Basel)

PubMed ID: 38339304

Doi: 10.3390/cancers16030553

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Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44

Authors: Emily M Cross, Oriano Marin, Daryl Ariawan, David Aragão, Giorgio Cozza, Enzo Di Iorio, Jade K Forwood, Gualtiero Alvisi

Journal: FEBS Lett

PubMed ID: 38158756

Doi: 10.1002/1873-3468.14797

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Myosin Va-dependent Transport of NMDA Receptors in Hippocampal Neurons

Authors: Ru Gong, Linwei Qin, Linlin Chen, Ning Wang, Yifei Bao, Wei Lu

Journal: Neurosci Bull

PubMed ID: 38291290

Doi: 10.1007/s12264-023-01174-y

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Revamped mini-αA-crystallin showed improved skin permeation and therapeutic activity against melittin-induced toxicity

Authors: Tenzin Tender, Rakesh Ravishankar Rahangdale, Madhavan Nampoothiri, Ruchira Raychaudhuri, Srinivas Mutalik, Krishna Sharma, Raghu Chandrashekar H

Journal: Toxicon

PubMed ID: 38211805

Doi: 10.1016/j.toxicon.2024.107611

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Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors

Authors: Chih-Wei Chu, Tomislav Čaval, Frederico Alisson-Silva, Akshaya Tankasala, Christina Guerrier, Gregg Czerwieniec, Heinz Läubli, Flavio Schwarz

Journal: Life Sci Alliance

PubMed ID: 38176728

Doi: 10.26508/lsa.202302368

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Development of Moloney Murine Leukemia Virus Reverse Transcriptase Fused with Archaeal DNA-binding Protein Sis7a

Authors: Goldyna M Simanjuntak, Azzania Fibriani, Amalia A Fananda, Nicholas Yamahoki

Journal: Recent Pat Biotechnol

PubMed ID: 37016518

Doi: 10.2174/1872208317666230403104302

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IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway

Authors: Weifeng Xu, Rui Chao, Xinru Xie, Yi Mao, Xinwei Chen, Xuzhuo Chen, Shanyong Zhang

Journal: Cell Commun Signal

PubMed ID: 38291404

Doi: 10.1186/s12964-023-01423-7

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Inactivation mechanism of cold plasma combined with 222 nm ultraviolet for spike protein and its application in disinfecting of SARS-CoV-2

Authors: Xiaowei Sheng, Jin Wang, Luling Zhao, Wenjing Yan, Jing Qian, Zhaobin Wang, Jianhao Zhang, Vijaya Raghavan

Journal: J Hazard Mater

PubMed ID: 38215522

Doi: 10.1016/j.jhazmat.2024.133458

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Biosynthesis of 10-Hydroxy-2-decenoic Acid through a One-Step Whole-Cell Catalysis

Authors: Ke Fang , Ziting Xu , Lu Yang , Quan Cui , Bowen Du , Huijing Liu , Ruiming Wang , Piwu Li , Jing Su , Junqing Wang

Journal: J Agric Food Chem .

PubMed ID: 38175798

Doi: 10.1021/acs.jafc.3c08142

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Let-7a-5p Regulates Animal Lipid Accumulation by Targeting Srebf2 and Thbs1 Signaling

Authors: Jiahao Shao , Genglong Jiang , Yanhong Li, Meigui Wang, Tao Tang, Jie Wang , Xianbo Jia and Songjia Lai

Journal: Int. J. Mol. Sci

Doi: 10.3390/ijms25020894

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Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity

Authors: Susan X N Lin, Philip K Ahring, Angelo Keramidas, Vivian W Y Liao, Rikke S Møller, Mary Chebib, Nathan L Absalom

Journal: Brain

PubMed ID: 37647766

Doi: 10.1093/brain/awad285

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PIEZO1 loss-of-function compound heterozygous mutations in the rare congenital human disorder Prune Belly Syndrome

Authors: Nathalia G Amado , Elena D Nosyreva , David Thompson , Thomas J Egeland , Osita W Ogujiofor , Michelle Yang , Alexandria N Fusco , Niccolo Passoni , Jeremy Mathews , Brandi Cantarel , Linda A Baker , Ruhma Syeda

Journal: Nat Commun

PubMed ID: 38184690

Doi: 10.1038/s41467-023-44594-0

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A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

Authors: Gregory H Bird , J J Patten , William Zavadoski , Nicole Barucci , Marina Godes , Benjamin M Moyer , Callum D Owen , Paul DaSilva-Jardine , Donna S Neuberg , Richard A Bowen , Robert A Davey , Loren D Walensky

Journal: Nat Commun

PubMed ID: 38177138

Doi: 10.1038/s41467-023-44361-1

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Massively parallel profiling of RNA-targeting CRISPR-Cas13d

Authors: Hung-Che Kuo , Joshua Prupes , Chia-Wei Chou , Ilya J Finkelstein

Journal: Nat Commun

PubMed ID: 37034598

Doi: 10.1101/2023.03.27.534188

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9S1R nullomer peptide induces mitochondrial pathology, metabolic suppression, and enhanced immune cell infiltration, in triple-negative breast cancer mouse model

Authors: Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R Veerabhadraiah, Laura Bond, Matthew W Turner, Cheryl L Jorcyk, Greg Hampikian

Journal: Biomed Pharmacother

PubMed ID: 38118350

Doi: 10.1016/j.biopha.2023.115997.

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Redox signalling regulates breast cancer metastasis via phenotypic and metabolic reprogramming due to p63 activation by HIF1α

Authors: Zuen Ren, Malindrie Dharmaratne, Huizhi Liang, Outhiriaradjou Benard, Miriam Morales-Gallego, Kimita Suyama, Viney Kumar, Atefeh Taherian Fard, Ameya S Kulkarni, Michael Prystowsky, Jessica C Mar, Larry Norton, Rachel B Hazan

Journal: Br J Cancer

PubMed ID: 38238426

Doi: 10.1038/s41416-023-02522-5

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Surface-modified measles vaccines encoding oligomeric, prefusion-stabilized SARS-CoV-2 spike glycoproteins boost neutralizing antibody responses to Omicron and historical variants, independent of measles seropositivity

Authors: Miguel Á Muñoz-Alía, Rebecca A Nace, Baskar Balakrishnan, Lianwen Zhang, Nandakumar Packiriswamy, Gagandeep Singh, Prajakta Warang, Ignacio Mena, Riya Narjari, Rianna Vandergaast, Kah-Whye Peng, Adolfo García-Sastre, Michael Schotsaert, Stephen J Russell

Journal: MBio

PubMed ID: 38193729

Doi: 10.1128/mbio.02928-23

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An immunocytokine consisting of a TNFR2 agonist and TNFR2 scFv enhances the expansion of regulatory T cells through TNFR2 clustering

Authors: Masaki Inoue, Yuta Tsuji, Ayaka Kashiwada, Asahi Yokoyama, Akane Iwata, Yasuhiro Abe, Haruhiko Kamada, Shin-Ichi Tsunoda

Journal: Biochem Biophys Res Commun

PubMed ID: 38262291

Doi: 10.1016/j.bbrc.2024.149498

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Production of recombinant HPV11/16 E6/E7-MBP-His fusion proteins and their potential to induce cytokine secretion by immune cells in peripheral blood

Authors: Mei-Nian Xu, Mei-Zhen Zhong, Si-Ning Feng, Yan-Qin Xu, Xiao-Ming Peng, Kang Zeng, Xiao-Wen Huang

Journal: Virol J

PubMed ID: 38183109

Doi: 10.1186/s12985-023-02281-y

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DOCK4 is a Novel Prognostic Biomarker and Correlated with Immune Infiltrates in Colon Adenocarcinoma

Authors: Xingjiang Xie, Yi Lu, Bo Wang, Xiaobin Yin, Jianfeng Chen

Journal: Comb Chem High Throughput Screen

PubMed ID: 37702239

Doi: 10.2174/1386207326666230912094101

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Cross-species immunoprotective antigens (subolesin, ferritin 2 and P0) provide protection against Rhipicephalus sanguineus sensu lato

Authors: Ismail Zeb, Luís Fernando Parizi, Muhammad Israr, Itabajara da Silva Vaz, Abid Ali

Journal: Parasit Vectors

PubMed ID: 38172894

Doi: 10.1186/s13071-023-06079-3

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Nanobodies as potential tools for microbiological testing of live biotherapeutic products

Authors: Robert J Dorosky, Jeremy E Schreier, Stephanie L Lola, Rosa L Sava, Michael P Coryell, Adovi Akue, Mark KuKuruga, Paul E Carlson, Sheila M Dreher-Lesnick, Scott Stibitz

Journal: AMB Express

PubMed ID: 38245586

Doi: 10.1186/s13568-023-01659-z

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Oral delivery of bacteria expressing wsv108 gene-specific dsRNA protects shrimp from white spot syndrome virus (WSSV) infection

Authors: Linwei Yang, Siyou Huang, Zi-Ang Wang, Deyu Han, Yushi Gan, Ran Geng, Hongliang Zuo, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu

Journal: Int J Biol Macromol

PubMed ID: 38302014

Doi: 10.1016/j.ijbiomac.2024.129840

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Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase

Authors: Marlo K Thompson, Nidhi Sharma, Andrea Thorn, Aishwarya Prakash

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 38289715

Doi: 10.1107/S205979832400038X

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Longitudinal analysis of antibody responses to Plasmodium vivax sporozoite antigens following natural infection

Authors: Pongsakorn Thawornpan, Justin Nicholas, Chayapat Malee, Piyawan Kochayoo, Kittikorn Wangriatisak, Pachara Tianpothong, Francis Babila Ntumngia, Samantha J Barnes, John H Adams, Patchanee Chootong

Journal: PLoS Negl Trop Dis

PubMed ID: 38277340

Doi: 10.1371/journal.pntd.0011907

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Identification and Functional Characterization of Oxidosqualene Cyclases from Medicinal Plant

Authors: Iffat Parveen, Mei Wang, Joseph Lee, Jianping Zhao, Yingjie Zhu, Amar G Chittiboyina, Ikhlas A Khan, Zhiqiang Pan

Journal: Plants (Basel)

PubMed ID: 38256784

Doi: 10.3390/plants13020231

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A dual-functional oncolytic adenovirus ZD55-aPD-L1 scFv armed with PD-L1 inhibitor potentiates its antitumor activity

Authors: Shengsheng Mei, Shanshan Peng, Eu Gene Vong, Jinbiao Zhan

Journal: Int Immunopharmacol

PubMed ID: 38278066

Doi: 10.1016/j.intimp.2024.111579

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Mulberry-derived miR168a downregulates BmMthl1 to promote physical development and fecundity in silkworms

Authors: Lin Chen, Jiubo Liang, Qi Zhang, Chao Yang, Hulin Lu, Renze Zhang, Kaiying Chen, Sheng Wang, Mingbo Li, Shaoyu Zhang, Ningjia He

Journal: Int J Biol Macromol

PubMed ID: 38199542

Doi: 10.1016/j.ijbiomac.2023.129077

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A novel fully human anti-NT-ANGPTL3 antibody from phage display library exhibits potent ApoB, TG, and LDL-C lowering activities in hyperlipidemia mice

Authors: Panpan Zhang, Ke Wang, Tuo Hu, Menglong Xu, Xiangyan You, Manman Chen, Xuan Tang, Huajing Hu, Yiwei Jiang, Wenfeng Zhao, Shuhua Tan

Journal: FASEB J

PubMed ID: 38174870

Doi: 10.1096/fj.202301564RR

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Individual transmembrane domains of SfABCC2 from Spodoptera frugiperda do not serve as functional Cry1F receptors

Authors: Jianfeng Zhong, Rafael Ferreira Dos Santos, Heba Abdelgaffar, Caroline Placidi de Bortoli, Ahmad Raza, Juan Luis Jurat-Fuentes

Journal: Pestic Biochem Physiol

PubMed ID: 38458684

Doi: 10.1016/j.pestbp.2024.105777

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Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Authors: Yehudi Bloch, Jan Felix, Romain Merceron, Mathias Provost, Royan Alipour Symakani, Robin De Backer, Elisabeth Lambert, Ahmad R Mehdipour, Savvas N Savvides

Journal: Nat Struct Mol Biol

PubMed ID: 38287195

Doi: 10.1038/s41594-023-01190-6

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Temporal dynamics of the early immune response following Mycobacterium bovis infection of cattle

Authors: Thomas Holder, Sreenidhi Srinivasan, Adrian McGoldrick, Gareth A Williams, Simonette Palmer, John Clarke, Amanda O'Brien, Andrew J K Conlan, Nick Juleff, H Martin Vordermeier, Gareth J Jones, Vivek Kapur

Journal: Sci Rep

PubMed ID: 38297023

Doi: 10.1038/s41598-024-52314-x

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Multivalent Calixarene Complexation of a Designed Pentameric Lectin

Authors: Ronan J Flood, Linda Cerofolini, Marco Fragai, Peter B Crowley

Journal: Biomacromolecules

PubMed ID: 38227741

Doi: 10.1021/acs.biomac.3c01280

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Design of protein-binding peptides with controlled binding affinity: the case of SARS-CoV-2 receptor binding domain and angiotensin-converting enzyme 2 derived peptides

Authors: Giacomo Parisi, Roberta Piacentini, Alessio Incocciati, Alessandra Bonamore, Alberto Macone, Jakob Rupert, Elsa Zacco, Mattia Miotto, Edoardo Milanetti, Gian Gaetano Tartaglia, Giancarlo Ruocco, Alberto Boffi, Lorenzo Di Rienzo

Journal: Front Mol Biosci

PubMed ID: 38250735

Doi: 10.3389/fmolb.2023.1332359

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Proteome profiling of enriched membrane-associated proteins unraveled a novel sophorose and cello-oligosaccharide transporter in Trichoderma reesei

Authors: Karoline Maria Vieira Nogueira, Vanessa Mendes, Karthik Shantharam Kamath, Anusha Cheruku, Letícia Harumi Oshiquiri, Renato Graciano de Paula, Claudia Carraro, Wellington Ramos Pedersoli, Lucas Matheus Soares Pereira, Luiz Carlos Vieira, Andrei Stecca Steindorff, Ardeshir Amirkhani, Matthew J McKay, Helena Nevalainen, Mark P Molloy, Roberto N Silva

Journal: Microb Cell Fact

PubMed ID: 38229067

Doi: 10.1186/s12934-023-02279-9

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Improved Solubility and Stability of a Thermostable Carbonic Anhydrase via Fusion with Marine-Derived Intrinsically Disordered Solubility Enhancers

Authors:

Journal: Int J Mol Sci

PubMed ID: 38256209

Doi: 10.3390/ijms25021139

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ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis

Authors: Shen Li, Jiangbo Han, Jiongzhe Cao, Hong Han, Bin Lu, Tao Wen, Weiguo Bian

Journal: Environ Toxicol

PubMed ID: 38174997

Doi: 10.1002/tox.24131

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