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Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers

Authors: Sheenam Verma, Matthew J Dufort, Tayla M Olsen, Samantha Kimmel, Jasmine C Labuda, Sam Scharffenberger, Andrew T McGuire, Oliver J Harrison

Journal: Immunity

PubMed ID: 38723638

Doi: 10.1016/j.immuni.2024.04.014

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A cell cycle regulator, E2F2, and glucocorticoid receptor cooperatively transactivate the bovine alphaherpesvirus 1 immediate early transcription unit 1 promoter

Authors: Fouad S El-Mayet, Clinton Jones

Journal: J Virol

PubMed ID: 38771044

Doi: 10.1128/jvi.00423-24

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Recombinant Bile Salt Hydrolase Enhances the Inhibition Efficiency of Taurodeoxycholic Acid against Virulence

Authors: Tahrir Alenezi, Bilal Alrubaye, Ying Fu, Janashrit Shrestha, Samar Algehani, Hong Wang, Rohana Liyanage, Xiaolun Sun

Journal: Pathogens

PubMed ID: 38921762

Doi: 10.3390/pathogens13060464

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Identification of key genes affecting ventilator-induced diaphragmatic dysfunction in diabetic mice

Authors: Rongchun Xing, Haibo Yu, Jiangtao Yu, Rong Zeng, Zhijun Xiang, Haoli Ma, Gang Li, Yan Zhao

Journal: Front Genet

PubMed ID: 38784031

Doi: 10.3389/fgene.2024.1387688

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The three-dimensional structure of DapE from Enterococcus faecium reveals new insights into DapE/ArgE subfamily ligand specificity

Authors: Manuel Terrazas-López, Lilian González-Segura, Adelaida Díaz-Vilchis, Kelly Annecy Aguirre-Mendez, Naún Lobo-Galo, Alejandro Martínez-Martínez, Ángel G Díaz-Sánchez

Journal: Int J Biol Macromol

PubMed ID: 38740150

Doi: 10.1016/j.ijbiomac.2024.132281

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Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy

Authors: Chunwen Duan, Chengcheng Ding, Xihao Sun, Shengru Mao, Yuqin Liang, Xinyu Liu, Xiaoyan Ding, Jiansu Chen, Shibo Tang

Journal: Stem Cell Res Ther

PubMed ID: 38816767

Doi: 10.1186/s13287-024-03767-4

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Loss of a conserved C-terminal region of the AtrR transcriptional regulator leads to a gene-specific defect in target gene expression

Authors: Shivani Ror, Mark A Stamnes, W Scott Moye-Rowley

Journal: biorxiv

PubMed ID: 38826412

Doi: 10.1101/2024.05.22.595332

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Assessing the Impact of Novel Exon 11 Variants on Pre-mRNA Splicing

Authors: Halla Elshwekh, Inas M Alhudiri, Adam Elzagheid, Nabil Enattah, Yasmine Abbassi, Lubna Abou Assali, Ilenia Marino, Cristiana Stuani, Emanuele Buratti, Maurizio Romano

Journal: Cells

PubMed ID: 38786046

Doi: 10.3390/cells13100824

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The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism

Authors: Felipe Paredes, Holly C Williams, Xuesong Liu, Claire Holden, Bethany Bogan, Yu Wang, Kathryn M Crotty, Samantha M Yeligar, Alvaro A Elorza, Zhiyong Lin, Amir Rezvan, Alejandra San Martin

Journal: Redox Biol

PubMed ID: 38823208

Doi: 10.1016/j.redox.2024.103203

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Prominin 1 is crucial for the early development of photoreceptor outer segments

Authors: Sila Yanardag, Scott Rhodes, Thamaraiselvi Saravanan, Tongju Guan, Visvanathan Ramamurthy

Journal: Sci Rep

PubMed ID: 38714794

Doi: 10.1038/s41598-024-60989-5

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Virus-like particles expressing microneme-associated antigen of Plasmodium berghei confer better protection than those expressing apical membrane antigen 1

Authors: Min-Ju Kim, Ki Back Chu, Keon-Woong Yoon, Hae-Ji Kang, Dong-Hun Lee, Eun-Kyung Moon, Fu-Shi Quan

Journal: Parasites Hosts Dis

PubMed ID: 38835260

Doi: 10.3347/PHD.24017

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Characterization of an agmatine N-acetyltransferase from Bactrocera dorsalis that modulates ovary development

Authors: Fei-Yue Teng, Ji-Mei Feng, Fu-Cai Ma, Zhuo-Xin Wang, Yong-Yue Lu, Yi-Xiang Qi

Journal: Insect Biochem Mol Biol

PubMed ID: 38734116

Doi: 10.1016/j.ibmb.2024.104130

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Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease

Authors: Alexandra M D'Ordine, Gerwald Jogl, John M Sedivy

Journal: Nat Commun

PubMed ID: 38719805

Doi: 10.1038/s41467-024-48066-x

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A Naturally Active Spy Transposon Discovered from the Insect Genome of Colletes gigas as a Promising Novel Gene Transfer Tool

Authors: Mohamed Diaby, Han Wu, Bo Gao, Shasha Shi, Bingqing Wang, Saisai Wang, Yali Wang, Zherui Wu, Cai Chen, Xiaoyan Wang, Chengyi Song

Journal: Adv Sci (Weinh)

PubMed ID: 38774947

Doi: 10.1002/advs.202400969

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One-pot sustainable synthesis of glucosylglycerate from starch and glycerol through artificial in vitro enzymatic cascade

Authors: Juanjuan Liu, Mengfei Ren, Haoran Ma, Huilin Zhang, Xinyu Cui, Runyuan Kang, Xinming Feng, Dongdong Meng

Journal: Bioresour Technol

PubMed ID: 38508282

Doi: 10.1016/j.biortech.2024.130611

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Wheat peptide alleviates DSS-induced colitis by activating the Keap1-Nrf2 signaling pathway and maintaining the integrity of the gut barrier

Authors: Wen-Yin Xie, Zhong-Hao Ji, Wen-Zhi Ren, Pei-Sen Zhao, Fan-Hao Wei, JinPing Hu, Bao Yuan, Wei Gao

Journal: Food Funct .

PubMed ID: 38690672

Doi: 10.1039/d3fo04413k.

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Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity

Authors: Min Wu, Guangping Song, Jianing Li, Zengqing Song, Bing Zhao, Liyun Liang, Wenlong Li, Huaibin Hu, Haiqing Tu, Sen Li, Peiyao Li, Biyu Zhang , Wen Wang, Yu Zhang , Wanpeng Zhang, Weifan Zheng, Jiarong Wang, Yuqi Wen, Kai Wang, Ailing Li, Tao Zhou, Yucheng Zhang, Huiyan Li

Journal: Cell

Doi: 10.1016/j.cell.2024.04.027

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Development of advanced control material for reverse transcription-mediated bacterial nucleic acid amplification tests

Authors: Janessa D Lewis , Stephen J Salipante

Journal: J Clin Microbiol

PubMed ID: 38629844

Doi: 10.1128/jcm.00243-24

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CRISPR/Cas13a-based supersensitive circulating tumor DNA assay for detecting EGFR mutations in plasma

Authors: Li Wang , Xiaosha Wen , Yang Yang , Zheng Hu , Jing Jiang , Lili Duan , Xiaofen Liao , Yan He , Yaru Liu , Jing Wang , Zhikun Liang , Xiaoya Zhu , Quan Liu , Tiancai Liu , Dixian Luo

Journal: Commun Biol

PubMed ID: 38806596

Doi: 10.1038/s42003-024-06368-2

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The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation

Authors: Joanne Saldanha , Julie Rageul , Jinal A Patel , Amy L Phi , Natalie Lo , Jennifer J Park , Hyungjin Kim

Journal: Nucleic Acids Res

PubMed ID: 38801073

Doi: 10.1093/nar/gkae445.

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Functional Application of the Single-Module NRPS-like D-Alanyltransferase in Maytansinol Biosynthesis

Authors: Zhongyue Li, Zhonghang Zhu, Guangsen Xu, Lin Wei, Jiang Liu, Haoxin Wang, Chunhua Lu, Yaoyao Li, Deyu Zhu*, and Yuemao Shen

Journal: ACS Catal

Doi: 10.1021/acscatal.4c00082

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Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes

Authors: Fleur Chapus 1, Guillaume Giraud 2, Pélagie Huchon 3, Mélanie Rodà 2, Xavier Grand 2, Caroline Charre 4, Chloé Goldsmith 5, Armando Andres Roca Suarez 2, Maria-Guadalupe Martinez 1, Judith Fresquet 6, Audrey Diederichs 3, Maëlle Locatelli 1, Hélène Polvèche 7, Caroline Scholtès 8, Isabelle Chemin 2, Hector Hernandez Vargas 5, Michel Rivoire 9, Cyril F Bourgeois 10, Fabien Zoulim 11, Barbara Testoni 12

Journal: J Hepatol

PubMed ID: 38782119

Doi: doi: 10.1016/j.jhep.2024.05.016.

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Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir

Authors: Yunxia Xu, Yaqi Wu, Xiaoying Wu, Yuanyuan Zhang, Yaxue Yang, Danyang Li, Biao Yang, Kaiting Gao, Zhengyu Zhang, Changjiang Dong

Journal: Int J Biol Macromol

PubMed ID: 38735603

Doi: 10.1016/j.ijbiomac.2024.132231

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but not is the avirulence determinant in melon carrying the resistance against watermelon mosaic virus, although they contain a common genetic determinant

Authors: Zhen Sun, Yu-Xuan Wu, Ling-Zhi Liu, Yan-Ping Tian, Xiang-Dong Li, Chao Geng

Journal: J Virol

PubMed ID: 38775482

Doi: 10.1128/jvi.00507-24

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Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis

Authors: Jiaojiao Xie, Jiapin Yan, Keru Ji, Yuejun Guo, Sibei Xu, Danjie Shen, Chen Li, Hongchang Gao, Liangcai Zhao

Journal: Int J Biol Macromol

PubMed ID: 38801850

Doi: 10.1016/j.ijbiomac.2024.132667

Products & Services: Molecular Biology Reagents

Fungicidal Activity of New Pyrrolo[2,3-]thiazoles and Their Potential Action on the Tryptophan Metabolic Pathway and Wax Biosynthesis

Authors: Yue Zhang, Jing Li, Hongwei Yang, Kun Li, Haolin Yuan, Ziqiao Xue, Liangfu Tang, Zhijin Fan

Journal: J Agric Food Chem

PubMed ID: 38757490

Doi: 10.1021/acs.jafc.4c00930

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The MuSK agonist antibody protects the neuromuscular junction and extends the lifespan in C9orf72-ALS mice

Authors: Shuangshuang Sun, Yihui Shen, Xu Zhang, Ning Ding, Zhe Xu, Qijie Zhang, Lei Li

Journal: Mol Ther

PubMed ID: 38734896

Doi: 10.1016/j.ymthe.2024.05.016

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Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Authors: Tomas O Jensen, Thomas A Murray, Greg A Grandits, Mamta K Jain, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko

Journal: Lancet Microbe

PubMed ID: 38815595

Doi: 10.1016/S2666-5247(24)00015-6

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Nanolevel of detection of ascorbic acid using horse-radish peroxidase inhibition assay

Authors: Bijon Kumar Sil, Mohd Raeed Jamiruddin, Md Ahsanul Haq, Nattanit Aekwattanaphol, Prem Ananth K, Limbadri Salendra, Himanshu Paliwal, Pijush Kumar Paul, Wilaiporn Buatong, Teerapol Srichana

Journal: Heliyon

PubMed ID: 38774337

Doi: 10.1016/j.heliyon.2024.e30715

Products & Services: Protein Electrophoresis and Western

Earliest records of the Asian longhorned tick (Acari: Ixodidae) in Staten Island, New York, and subsequent population establishment, with a review of its potential medical and veterinary importance in the United States

Authors: Waheed Bajwa, Ashley Kennedy, Zachary Vincent, Garrett Heck, Shamim Riaj, Zahir Shah, Leonid Tsynman, Cory Casal, Scott Haynes, Hannah Cornman, Andrea Egizi, Ellen Stromdahl, Robyn Nadolny

Journal: J Med Entomol

PubMed ID: 38412407

Doi: 10.1093/jme/tjae019

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Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes

Authors: Samuel Liwei Leong, Lawton Murdolo, Janesha C Maddumage, Marios Koutsakos, Katherine Kedzierska, Anthony W Purcell, Stephanie Gras, Emma J Grant

Journal: Clin Transl Immunology

PubMed ID: 38737448

Doi: 10.1002/cti2.1509

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A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles

Authors: Jonathan R Hernandez, Caixing Xiong, Patricia V Pietrantonio

Journal: Sci Rep

PubMed ID: 38740831

Doi: 10.1038/s41598-024-61570-w

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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation

Authors: Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen

Journal: J Transl Med

PubMed ID: 38720345

Doi: 10.1186/s12967-024-05261-0

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Evolution of a novel adrenal cell type that promotes parental care

Authors: Natalie Niepoth, Jennifer R Merritt, Michelle Uminski, Emily Lei, Victoria S Esquibies, Ina B Bando, Kimberly Hernandez, Christoph Gebhardt, Sarah A Wacker, Stefano Lutzu, Asmita Poudel, Kiran K Soma, Stephanie Rudolph, Andres Bendesky

Journal: Nature

PubMed ID: 38750354

Doi: 10.1038/s41586-024-07423-y

Products & Services: Molecular Biology Reagents

Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1

Authors: Kyle Scranton, Scott John, Marina Angelini, Federica Steccanella, Soban Umar, Rui Zhang, Joshua I Goldhaber, Riccardo Olcese, Michela Ottolia

Journal: Nat Commun

PubMed ID: 38714663

Doi: 10.1038/s41467-024-47850-z

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Nonclinical Evaluation of Single-Mutant Asparaginases Obtained by Double-Mutant Deconvolution: Improving Toxicological, Immune and Inflammatory Responses

Authors: Grace Ruiz-Lara, Tales A Costa-Silva, Jorge Javier Muso-Cachumba, Johanna Cevallos Espinel, Marina Gabriel Fontes, Mitla Garcia-Maya, Khondaker Miraz Rahman, Carlota de Oliveira Rangel-Yagui, Gisele Monteiro

Journal: Int J Mol Sci

PubMed ID: 38892196

Doi: 10.3390/ijms25116008

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Podocyte Pathogenic Bone Morphogenetic Protein-2 Pathway and Immune Cell Behaviors in Primary Membranous Nephropathy

Authors: Anxiang Cai, Yiwei Meng, Hang Zhou, Hong Cai, Xinghua Shao, Qin Wang, Yao Xu, Yin Zhou, Wenyan Zhou, Luonan Chen, Shan Mou

Journal: Adv Sci (Weinh)

PubMed ID: 38785168

Doi: 10.1002/advs.202404151

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Context dependent activity of p63-bound gene regulatory elements

Authors: Abby A McCann, Gabriele Baniulyte, Dana L Woodstock, Morgan A Sammons

Journal: biorxiv

PubMed ID: 38766006

Doi: 10.1101/2024.05.09.593326

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Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Authors: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M Falkowski, Thomas G Biel, Tongzhong Ju, Wen Jin Wu

Journal: Front Immunol

PubMed ID: 38863707

Doi: 10.3389/fimmu.2024.1376096

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LncRNA CCRR maintains Ca homeostasis against myocardial infarction through the FTO-SERCA2a pathway

Authors: Hua Yang, Lina Xuan, Shengjie Wang, Huishan Luo, Xiaomeng Duan, Jianjun Guo, Shijia Cui, Jieru Xin, Junwei Hao, Xiufang Li, Jun Chen, Feihan Sun, Xiaolin Hu, Siyun Li, Ying Zhang, Lei Jiao, Baofeng Yang, Lihua Sun

Journal: Sci China Life Sci

PubMed ID: 38761356

Doi: 10.1007/s11427-023-2527-5

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Conditional knockdown of OsMLH1 to improve plant prime editing systems without disturbing fertility in rice

Authors: Xiaoshuang Liu, Dongfang Gu, Yiru Zhang, Yingli Jiang, Zhi Xiao, Rongfang Xu, Ruiying Qin, Juan Li, Pengcheng Wei

Journal: Genome Biol

PubMed ID: 38773623

Doi: 10.1186/s13059-024-03282-y

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Functional characterization of a novel flavin reductase from a deep-sea sediment metagenomic library and its application for indirubin production

Authors: Jikun Du, Yuanhua Li, Zhengzhuang Chen, Chang Wang, Yali Huang, Li Li

Journal: Appl Environ Microbiol

PubMed ID: 38780258

Doi: 10.1128/aem.00429-24

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and analysis reveal impact of c-Myc tag in FMC63 scFv-CD19 protein interface and CAR-T cell efficacy

Authors: Ana Julia Ferreira Lima, Karina Lobo Hajdu, Luiza Abdo, Leonardo Ribeiro Batista-Silva, Clara de Oliveira Andrade, Eduardo Mannarino Correia, Emmanuel Arthur Albuquerque Aragão, Martín Hernán Bonamino, Marcos Roberto Lourenzoni

Journal: Comput Struct Biotechnol J

PubMed ID: 38873646

Doi: 10.1016/j.csbj.2024.05.032

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CircRNA SEC24A promotes osteoarthritis through miR-107-5p/CASP3 axis

Authors: Tuerxunjiang Dadihanc, Yong Zhang, Guo-Qing Li, Hai-Kang Zhou, Jingyong Huang, Xue Zhang, Zhi-Qiang Li, Hai-Rong Ma

Journal: Regen Ther

PubMed ID: 38828010

Doi: 10.1016/j.reth.2024.04.011

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SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress

Authors: Shuaiyang Jing, Jingkai Gao, Neeraj Tiwari, Yulei Du, Lianhui Zhu, Bopil Gim, Yi Qian, Xihua Yue, Intaek Lee

Journal: Commun Biol

PubMed ID: 38710927

Doi: 10.1038/s42003-024-06232-3

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Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease

Authors: Emelie E Aspholm, Jens Lidman, Björn M Burmann

Journal: Nat Commun

PubMed ID: 38816423

Doi: 10.1038/s41467-024-48997-5

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A new suite of reporter vectors and a novel landing site survey system to study cis-regulatory elements in diverse insect species

Authors: Kevin D Deem, Marc S Halfon, Yoshinori Tomoyasu

Journal: Sci Rep

PubMed ID: 38698030

Doi: 10.1038/s41598-024-60432-9

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Identification of an Immunodominant B-Cell Epitope in African Swine Fever Virus p30 Protein and Evidence of p30 Antibody-Mediated Antibody Dependent Cellular Cytotoxicity

Authors: Jessica C G Noll, Ruchi Rani, Salman L Butt, Maureen Hoch Vieira Fernandes, Gabriela Mansano do Nascimento, Mathias Martins, Leonardo C Caserta, Lina Covaleda, Diego G Diel

Journal: Viruses

PubMed ID: 38793639

Doi: 10.3390/v16050758

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Single dual-specific anti-PD-L1/TGF-β antibody synergizes with chemotherapy as neoadjuvant treatment for pancreatic ductal adenocarcinoma: a preclinical experimental study

Authors: Haoxiang Zhang, Jiaoshun Chen, Jianwei Bai, Jing Zhang, Shaoyi Huang, Liang Zeng, Pengfei Zhou, Qiang Shen, Tao Yin

Journal: Int J Surg

PubMed ID: 38489548

Doi: 10.1097/JS9.0000000000001226

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Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters

Authors: Megan Levy, Jessica W Chen, Jaclyn A Kaiser, Hong-Su Park, Xueqiao Liu, Lijuan Yang, Celia Santos, Ursula J Buchholz, Cyril Le Nouën

Journal: PLoS Pathog

PubMed ID: 38739647

Doi: 10.1371/journal.ppat.1012198

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Divergent effects of olfactory receptors on transient receptor potential vanilloid 1 activation by capsaicin and eugenol

Authors: Sakura Moriyama, Yukie Takita, Shuji Hinuma, Shun'ichi Kuroda

Journal: Biosci Biotechnol Biochem

PubMed ID: 38734894

Doi: 10.1093/bbb/zbae060

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Semi-rational design for enhancing thermostability of Culex pipiens acetylcholinesterase and sensitivity analysis of acephate

Authors: Shuoqi Jiang, Zhuangwei Zhang, Qiuya Gu, Xiaobin Yu

Journal: Sci Total Environ

PubMed ID: 38759926

Doi: 10.1016/j.scitotenv.2024.173282

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HSD17B13 liquid-liquid phase separation promotes leukocyte adhesion in chronic liver inflammation

Authors: Jing Ye, Xiyu Huang, Manman Yuan, Jinglin Wang, Ru Jia, Tianyi Wang, Yang Tan, Shun Zhu, Qiang Xu, Xingxin Wu

Journal: J Mol Cell Biol

PubMed ID: 38692847

Doi: 10.1093/jmcb/mjae018

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Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms

Authors: Jiaqi Fu, Siying Li, Hongxin Guan, Chuang Li, Tao-Tao Chen, Wei Xian, Zhengrui Zhang, Yao Liu, Qingtian Guan, Jingting Wang, Qiuhua Lu, Lina Kang, Si-Ru Zheng, Jinyu Li, Shoujing Cao, Chittaranjan Das, Xiaoyun Liu, Lei Song, Songying Ouyang, Zhao-Qing Luo

Journal: Res Sq

PubMed ID: 38826349

Doi: 10.21203/rs.3.rs-4431542/v1

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Characterization of Esterase Capable of Hydrolyzing Bis(2-hydroxyethyl) Terephthalate

Authors: Sizhong Feng, Mengke Xue, Fang Xie, Hongyang Zhao, Yemin Xue

Journal: J Agric Food Chem

PubMed ID: 38753963

Doi: 10.1021/acs.jafc.4c01973

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Hybrid Cas12a Variants with Relaxed PAM Requirements Expand Genome Editing Compatibility

Authors: Zhenyu Liu, Huayi Liu, Chaoqun Huang, Qun Zhou, Yunzi Luo

Journal: ACS Synth Biol

PubMed ID: 38819403

Doi: 10.1021/acssynbio.4c00103

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A "One-Step" Strategy for the Global Characterization of Core-Fucosylated Glycoproteome

Authors: Yuqiu Wang, Rui Yuan, Bo Liang, Jing Zhang, Qin Wen, Hongxu Chen, Yinping Tian, Liuqing Wen, Hu Zhou

Journal: JACS Au

PubMed ID: 38818065

Doi: 10.1021/jacsau.4c00214

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Aβ and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer's disease

Authors: Liding Zhang, Kai Cao, Jun Xie, Xiaohan Liang, Hui Gong, Qingming Luo, Haiming Luo

Journal: J Nanobiotechnology

PubMed ID: 38783363

Doi: 10.1186/s12951-024-02543-z

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The 6-kilodalton peptide 1 in plant viruses of the family Potyviridae is a viroporin

Authors: Mengzhu Chai, Lei Li, Yong Li, Yingshuai Yang, Yuting Wang, Xue Jiang, Yameng Luan, Fangfang Li, Hongguang Cui, Aiming Wang, Wensheng Xiang, Xiaoyun Wu, Xiaofei Cheng

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38739789

Doi: 10.1073/pnas.2401748121

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Bazi Bushen alleviates reproductive aging in aged male mice

Authors: Kun Ma, Mengnan Li, Yahui Song, Xinjing Mao, Shaolan Zhang, Yaping Zhang, Yuning Jiang, Chuanyuan Ji, Kunxu Niu, Hongrong Li, Yunlong Hou, Cong Wei

Journal: Chin J Nat Med

PubMed ID: 38796215

Doi: 10.1016/S1875-5364(24)60639-4

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Virus-like particle-based multipathogen vaccine of FMD and SVA elicits balanced and broad protective efficacy in mice and pigs

Authors: Hetao Song, Sahibzada Waheed Abdullah, Shuanghui Yin, Hu Dong, Yun Zhang, Shuzhen Tan, Manyuan Bai, Yaozhong Ding, Zhidong Teng, Shiqi Sun, Huichen Guo

Journal: Vaccine

PubMed ID: 38714448

Doi: 10.1016/j.vaccine.2024.04.092

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POLR2J expression promotes glioblastoma malignancy by regulating oxidative stress and the STAT3 signaling pathway

Authors: Xiao-Li Zheng, Zhi-Di Li, Kai-Zhi Luo, Yang-Ling Li, Ye-Han Liu, Shu-Ying Shen, Fei-Yan Shen, Wan-Yan Li, Guo-Qing Chen, Chong Zhang, Ling-Hui Zeng

Journal: Am J Cancer Res

PubMed ID: 38859843

Doi: 10.62347/JEWM7691

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Functional characterization of the InR/PI3K/AKT signaling pathway in female reproduction of the predatory bug Cyrtorhinus lividipennis (Hemiptera: Miridae)

Authors: Kui Hu, Rong Jin, Jianqi Liu, Jun Zhu, Wei Dai, Ying Wang, Yao Li, Fang Liu

Journal: J Econ Entomol

PubMed ID: 38783398

Doi: 10.1093/jee/toae113

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Alpha and gamma mangostins inhibit wild-type B SARS-CoV-2 more effectively than the SARS-CoV-2 variants and the major target is unlikely the 3C-like protease

Authors: Aphinya Suroengrit, Van Cao, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Kowit Hengphasatporn, Ryuhei Harada, Supakarn Chamni, Asada Leelahavanichkul, Yasuteru Shigeta, Thanyada Rungrotmongkol, Supot Hannongbua, Warinthorn Chavasiri, Supaporn Wacharapluesadee, Eakachai Prompetchara, Siwaporn Boonyasuppayakorn

Journal: Heliyon

PubMed ID: 38867992

Doi: 10.1016/j.heliyon.2024.e31987

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Discovery of UMI-77 as a novel Ku70/80 inhibitor sensitizing cancer cells to DNA damaging agents in vitro and in vivo

Authors: Xuening Chen, Changkun Chen, Chengmiao Luo, Jianyong Liu, Zhonghui Lin

Journal: Eur J Pharmacol

PubMed ID: 38754534

Doi: 10.1016/j.ejphar.2024.176647

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Discrimination of Aspartic and Isoaspartic Acid Residues in Peptides by Tandem Mass Spectrometry with Hydrogen Attachment Dissociation

Authors: Daiki Asakawa, Shinich Iwamoto, Koichi Tanaka

Journal: Anal Chem

PubMed ID: 38741470

Doi: 10.1021/acs.analchem.4c00561

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SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

Authors: Ze-Zheng Jiang, Min Chu, Li-Na Yan, Wen-Kang Zhang, Bang Li, Jiao Xu, Zhong-Xin Zhao, Hui-Ju Han, Chuan-Min Zhou, Xue-Jie Yu

Journal: Microbiol Spectr

PubMed ID: 38712963

Doi: 10.1128/spectrum.03796-23

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Functional Characterization of F3H Gene and Optimization of Dihydrokaempferol Biosynthesis in

Authors: Qinyi Chen, Dandan Song, Xiaoyan Sun, Yulong Tian, Zecheng Yan, Ting Min, Hongxun Wang, Limei Wang

Journal: Molecules

PubMed ID: 38792058

Doi: 10.3390/molecules29102196

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Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury

Authors: Yuhao Xu, Limoran Tang, Chao Zhou, Liang Sun, Yujie Hu, Zhi Zhang, Shengnan Xia, Xinyu Bao, Haiyan Yang, Yun Xu

Journal: CNS Neurosci Ther

PubMed ID: 38715283

Doi: 10.1111/cns.14742

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YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway

Authors: Yue Shi, Yue Cheng, Wei Wang, Liu Tang, Wensheng Li, Liyuan Zhang, Zheng Yuan, Feng Zhu, Qiuhong Duan

Journal: Sci Rep

PubMed ID: 38714727

Doi: 10.1038/s41598-024-61157-5

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Identification of a Fully Human Antibody VH Domain Targeting Anaplastic Lymphoma Kinase (ALK) with Applications in ALK-Positive Solid Tumor Immunotherapy

Authors: Chuan Chen, Zehua Sun, Zening Wang, Seungmin Shin, Abigail Berrios, John W Mellors, Dimiter S Dimitrov, Wei Li

Journal: Antibodies (Basel)

PubMed ID: 38804307

Doi: 10.3390/antib13020039

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Functional Analysis of the Major Pilin Proteins of Type IV Pili in CGMH010

Authors: Yi-Ywan M Chen, Yuan-Chen Yang, Hui-Ru Shieh, Yu-Juan Lin, Wan-Ju Ke, Cheng-Hsun Chiu

Journal: Int J Mol Sci

PubMed ID: 38791440

Doi: 10.3390/ijms25105402

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Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies

Authors: Roman R Schlimgen, Francis C Peterson, Raimond Heukers, Martine J Smit, John D McCorvy, Brian F Volkman

Journal: Nat Commun

PubMed ID: 38816420

Doi: 10.1038/s41467-024-49000-x

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Tardigrade secretory proteins protect biological structures from desiccation

Authors: Samuel Lim, Charles B Reilly, Zeina Barghouti, Benedetto Marelli, Jeffrey C Way, Pamela A Silver

Journal: Commun Biol

PubMed ID: 38796644

Doi: 10.1038/s42003-024-06336-w

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MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells

Authors: Yanmiao Dai, Yudong Xu, Jie Shen, Caihong Hu, Xiaoli Li, Yongyu Chen, Yao Liu, Duanmin Hu

Journal: Exp Cell Res

PubMed ID: 38802035

Doi: 10.1016/j.yexcr.2024.114099

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Dexmedetomidine enhances Mitophagy via PINK1 to alleviate hippocampal neuronal Pyroptosis and improve postoperative cognitive dysfunction in elderly rat

Authors: Yayu Chen, Gen Wei, Lieliang Zhang, Xiaojin Feng, Enjun Lei

Journal: Exp Neurol

PubMed ID: 38823674

Doi: 10.1016/j.expneurol.2024.114842

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Distinct components of nucleoside-modified messenger RNA vaccines cooperate to instruct efficient germinal center responses

Authors: Emily Bettini, Aleksey Chudnovskiy, Giulia Protti, Sandra Nakadakari-Higa, Simona Ceglia, Diana Castaño, Joy Chiu, Hiromi Muramatsu, Thandiswa Mdluli, Edit Abraham, Zoltan Lipinszki, Ivan Maillard, Ying K Tam, Andrea Reboldi, Norbert Pardi, Roberto Spreafico, Gabriel D Victora, Michela Locci

Journal: biorxiv

PubMed ID: 38798523

Doi: 10.1101/2024.05.17.594726

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Kinetic Characterization and Identification of Key Active Site Residues of the L-Aspartate N-Hydroxylase, CreE

Authors: Sydney B Johnson, Hannah Valentino, Pablo Sobrado

Journal: Chembiochem

PubMed ID: 38775737

Doi: 10.1002/cbic.202400350

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Structural Determinants of FeoB Nucleotide Promiscuity

Authors: Mark Lee, Kate Magante, Camilo Gómez-Garzón, Shelley M Payne, Aaron T Smith

Journal: biorxiv

PubMed ID: 38826458

Doi: 10.1101/2024.05.22.595361

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Staphylococcal peroxidase inhibitor (SPIN): Residue-level investigation of the helical bundle domain

Authors: Soheila Fatehi, Timothy J Herdendorf, Nicoleta T Ploscariu, Brian V Geisbrecht

Journal: Arch Biochem Biophys

PubMed ID: 38705227

Doi: 10.1016/j.abb.2024.110023

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Establishment of an ELISA Based on a Recombinant Antigenic Protein Containing Multiple Prominent Epitopes for Detection of African Swine Fever Virus Antibodies

Authors: Dossêh Jean Apôtre Afayibo, Zhonghui Zhang, Hualin Sun, Jingsheng Fu, Yaru Zhao, Tharheer Oluwashola Amuda, Mengli Wu, Junzheng Du, Guiquan Guan, Qingli Niu, Jifei Yang, Hong Yin

Journal: Microorganisms

PubMed ID: 38792774

Doi: 10.3390/microorganisms12050943

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Preparation and epitope analysis of monoclonal antibodies against African swine fever virus DP96R protein

Authors: Chao Li, Xuan-Ying Si, Xiao-Ge Wang, Zhi-Wei Yan, Hao-Yu Hou, Long-Qi You, Yin-Long Chen, Ang-Ke Zhang, Na Wang, Ai-Jun Sun, Yong-Kun Du, Gai-Ping Zhang

Journal: BMC Vet Res

PubMed ID: 38734611

Doi: 10.1186/s12917-024-04043-6

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Ser/Leu-swapped cell-free translation system constructed with natural/in vitro transcribed-hybrid tRNA set

Authors: Tomoshige Fujino, Ryogo Sonoda, Taito Higashinagata, Emi Mishiro-Sato, Keiko Kano, Hiroshi Murakami

Journal: Nat Commun

PubMed ID: 38755134

Doi: 10.1038/s41467-024-48056-z

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A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

Authors: Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu-Ichi Matsuzawa, Ryosuke Takahashi, Hodaka Yamakado

Journal: Mol Brain

PubMed ID: 38790036

Doi: 10.1186/s13041-024-01104-7

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Tracking single-cell evolution using clock-like chromatin accessibility loci

Authors: Yu Xiao, Wan Jin, Lingao Ju, Jie Fu, Gang Wang, Mengxue Yu, Fangjin Chen, Kaiyu Qian, Xinghuan Wang & Yi Zhang

Journal: Nature Biotechnol

PubMed ID: 38724668

Doi: 10.1038/s41587-024-02241-z

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Computational design of non-porous pH-responsive antibody nanoparticles

Authors: Erin C. Yang, Robby Divine, Marcos C. Miranda, Andrew J. Borst, Will Sheffler, Jason Z. Zhang, Justin Decarreau, Amijai Saragovi, Mohamad Abedi, Nicolas Goldbach, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, Suna Cheng, Mila Lamb, Paul M. Levine, Sidney Chan, Rebecca Skotheim, Jorge Fallas, George Ueda, Joshua Lubner, Masaharu Somiya, Alena Khmelinskaia, Neil P. King & David Baker

Journal: Nat Struct Mol Biol

PubMed ID: 38724718

Doi: 10.1038/s41594-024-01288-5

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A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila

Authors: Alka Singh, Kandahalli Venkataranganayaka Abhilasha, Kathya R. Acharya, Haibo Liu, Niraj K. Nirala, Velayoudame Parthibane, Govind Kunduri, Thiruvaimozhi Abimannan, Jacob Tantalla, Lihua Julie Zhu, Jairaj K. Acharya & Usha R. Acharya

Journal: Nat Commun

PubMed ID: 38782979

Doi: 10.1038/s41467-024-48851-8

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Engineering and evaluation of FXa bypassing agents that restore hemostasis following Apixaban associated bleeding

Authors: Wojciech Jankowski, Stepan S. Surov, Nancy E. Hernandez, Atul Rawal, Marcos Battistel, Daron Freedberg, Mikhail V. Ovanesov & Zuben E. Sauna

Journal: Nat Commun

PubMed ID: 38724509

Doi: 10.1038/s41467-024-48278-1

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Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

Authors: Shengjun Wang, Wei Ran, Lingyu Sun, Qingchi Fan, Yuanqi Zhao, Bowen Wang, Jinghong Yang, Yuqi He, Ying Wu, Yuanyuan Wang, Luoyi Chen, Arpaporn Chuchuay, Yuyu You, Xinhai Zhu, Xiaojuan Wang, Ye Chen, Yanqun Wang, Yao-Qing Chen, Yanqiu Yuan, Jincun Zhao & Yang Mao

Journal: Nat Commun

PubMed ID: 38755139

Doi: 10.1038/s41467-024-48503-x

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The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction

Authors: Xiaopan Gao, Bei Wang, Kaixiang Zhu, Linyue Wang, Bo Qin, Kun Shang, Wei Ding, Jianwei Wang & Sheng Cui

Journal: Nat Commun

PubMed ID: 38755176

Doi: 10.1038/s41467-024-48504-w

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The translocation of a chloride channel from the Golgi to the plasma membrane helps plants adapt to salt stress

Authors: Sivamathini Rajappa, Pannaga Krishnamurthy, Hua Huang, Dejie Yu, Jiří Friml, Jian Xu & Prakash P. Kumar

Journal: Nat Commun

PubMed ID: 38729926

Doi: 10.1038/s41467-024-48234-z

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The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis

Authors: Julia Zibold, Lola E R Lessard, Flavien Picard, Lara Gruijs da Silva, Yelyzaveta Zadorozhna, Nathalie Streichenberger, Edwige Belotti, Alexis Osseni, Andréa Emerit, Elisabeth Errazuriz-Cerda, Laurence Michel-Calemard, Rita Menassa, Laurent Coudert, Manuela Wiessner, Rolf Stucka, Thomas Klopstock, Francesca Simonetti, Saskia Hutten, Takashi Nonaka, Masato Hasegawa, Tim M Strom, Emilien Bernard, Elisabeth Ollagnon, Andoni Urtizberea, Dorothee Dormann, Philippe Petiot, Laurent Schaeffer, Jan Senderek, Pascal Leblanc

Journal: Brain

PubMed ID: 38079474

Doi: 10.1093/brain/awad410

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Oriented immobilization of antibodies through peptide ligands for ultrasensitive detection of gastrin 17 in human serum via lateral flow immunoassay

Authors: Xintong Li , Jiale Cui , Jin Li , Yulian Wang , Guoqing Shi

Journal: Microchemical Journal

Doi: j.microc.2024.110819

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Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing

Authors: Qiubing Chen, Xuebin Wang, Yizhou Zhang, Ming Tian, Junyi Duan, Ying Zhang, Hao Yin

Journal: NSR

Doi: 10.1093/nsr/nwae135

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microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

Authors: Xinghan Chen, Yueru Shen, Zheng Song, Xinliang Wang, Huaitong Yao, Yuan Cai, Zi-Ang Zhao, Bing Hu

Journal: J Genet Genomics

PubMed ID: 38582297

Doi: 10.1016/j.jgg.2024.03.016

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A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells

Authors: Hema Preethi Subas Satish, Sweta Iyer, Melissa X Shi, Agnes W Wong, Karla C Fischer, Ahmad Z Wardak, Daisy Lio, Jason M Brouwer, Rachel T Uren, Peter E Czabotar, Michelle S Miller, Ruth M Kluck

Journal: Cell Death Differ

PubMed ID: 38582955

Doi: 10.1038/s41418-024-01289-3

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The proteomic analysis uncovers the cellular responses to the African swine fever virus membrane proteins p54, p17, and pB117L

Authors: Yuhong Chen, Jianqiang Ni, Chuanbin Wang, Xinyan Zhai, Tingrong Luo, Yi-Ping Li, Youchuan Wei, Yuliang Liu

Journal: Microbes Infect

PubMed ID: 38697277

Doi: 10.1016/j.micinf.2024.105348

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Interleukin-2 is required for NKp30-dependent NK cell cytotoxicity by preferentially regulating NKp30 expression

Authors: Nayoung Kim, Eunbi Yi, Eunbi Lee, Hyo Jin Park, Hun Sik Kim

Journal: Front Immunol

PubMed ID: 38698855

Doi: 10.3389/fimmu.2024.1388018

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Knockdown of heat shock protein family D member 1 (HSPD1) in lung cancer cell altered secretome profile and cancer-associated fibroblast induction

Authors: Siripat Aluksanasuwan, Keerakarn Somsuan, Jatuporn Ngoenkam, Wararat Chiangjong, Artitaya Rongjumnong, Atthapan Morchang, Somchai Chutipongtanate, Sutatip Pongcharoen

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38663552

Doi: 10.1016/j.bbamcr.2024.119736

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Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure to infected mosquito bites

Authors: Sarah Lapidus, Morgan M Goheen, Mouhamad Sy, Awa B Deme, Ibrahima Mbaye Ndiaye, Younous Diedhiou, Amadou Moctar Mbaye, Kelly A Hagadorn, Seynabou Diouf Sene, Mariama Nicole Pouye, Laty Gaye Thiam, Aboubacar Ba, Noemi Guerra, Alassane Mbengue, Hamidah Raduwan, Inés Vigan-Womas, Sunil Parikh, Albert I Ko, Daouda Ndiaye, Erol Fikrig, Yu-Min Chuang, Amy K Bei

Journal: medrxiv

PubMed ID: 38712295

Doi: 10.1101/2024.04.20.24305430

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