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Structure of the recombinant RNA polymerase from African Swine Fever Virus

Authors: Simona Pilotto, Michal Sýkora, Gwenny Cackett, Christopher Dulson, Finn Werner

Journal: Nat Commun

PubMed ID: 38383525

Doi: 10.1038/s41467-024-45842-7

Products & Services: Proteins, Expression, Isolation and Analysis

Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization

Authors: Stephanie E Martinez, Amit V Pandey, Tania E Perez Jimenez, Zhaohui Zhu, Michael H Court

Journal: PLoS ONE

PubMed ID: 38300925

Doi: 10.1371/journal.pone.0297191

Products & Services: Mutagenesis Services

Critical Aggregation Concentration Can be a Predictor of Doxorubicin Delivery Performance of Self-Assembling Amphiphilic Peptides with Different Hydrophobic Tails

Authors: Saeed Zanganeh, Loghman Firoozpour, Maryam Samareh Salavatipour, Soroush Sardari, Reza Ahangari Cohan, Nasir Mohajel

Journal: J Pharm Sci

PubMed ID: 38417791

Doi: 10.1016/j.xphs.2024.02.022

Products & Services: Proteins, Expression, Isolation and Analysis

Impact of Antenatal SARS-CoV-2 Exposure on SARS-CoV-2 Neutralization Potency

Authors: Chia-Jung Chiang, Wei-Lun Hsu, Mei-Tsz Su, Wen-Chien Ko, Keng-Fu Hsu, Pei-Yin Tsai

Journal: Vaccines (Basel)

PubMed ID: 38400147

Doi: 10.3390/vaccines12020164

Products & Services: Proteins, Expression, Isolation and Analysis

Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism

Authors: Yilin Ren, Xinyi Shi, Jing Mu, Shenyin Liu, Xin Qian, Wenlong Pei, Shanhong Ni, Zhengduo Zhang, Lei Li, Zhan Zhang

Journal: Food Funct

PubMed ID: 38236135

Doi: 10.1039/d3fo04347a

Products & Services: Gene Synthesis

A Divalent Chikungunya and Zika Nanovaccine with Thermostable Self-Assembly Multivalent Scaffold LS-SUMO

Authors: Qianlin Li, Jinsong Zhang, Qiang Deng, Conghui Liao, Jun Qian, Zeliang Chen, Jiahai Lu

Journal: Adv Healthc Mater

PubMed ID: 38340040

Doi: 10.1002/adhm.202303619

Products & Services: Molecular Biology Reagents

Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons

Authors: Wenchao Gu, Sijin Luozhong, Simian Cai, Ketaki Londhe, Nadine Elkasri, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Yujie Yin, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Qiuming Yu, Melissa Warden, Robert Langer, Shaoyi Jiang

Journal: Nat Biomed Eng

PubMed ID: 38374224

Doi: 10.1038/s41551-023-01150-x

Products & Services: Gene Synthesis

Characterization of core oligosaccharide synthesis reveals novel aspects of lipooligosaccharide assembly

Authors: Leah M VanOtterloo, Luis A Macias, Matthew J Powers, Jennifer S Brodbelt, M Stephen Trent

Journal: MBio

PubMed ID: 38349180

Doi: 10.1128/mbio.03013-23

Products & Services: Gene Synthesis

Deciphering the origin of developmental stability: The role of intracellular expression variability in evolutionary conservation

Authors: Yui Uchida, Masato Tsutsumi, Shunsuke Ichii, Naoki Irie, Chikara Furusawa

Journal: Evol Dev

PubMed ID: 38414112

Doi: 10.1111/ede.12473

Products & Services: ORF cDNA Clones/MolecularCloud

Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I

Authors: Lisa Choy, Stephen Norris, Xiumin Wu, Ganesh Kolumam, Ari Firestone, Jeffrey Settleman, David Stokoe

Journal: Cancer Res Commun

PubMed ID: 38358346

Doi: 10.1158/2767-9764.CRC-23-0432

Products & Services: Codon Optimization

CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy

Authors: Peixia Tang , Zhen Yu , Hao Sun 2, Lanting Liu , Lixin Gong , Teng Fang , Xiyue Sun , Shiyi Xie , Gang An 2, Zhenshu Xu 3, Lugui Qiu 4, Mu Hao

Journal: EBioMedicine

PubMed ID: 38199044

Doi: 10.1016/j.ebiom.2023.104961

Products & Services: Proteins, Expression, Isolation and Analysis

Increasing β-hexosaminidase A activity using genetically modified mesenchymal stem cells

Authors: Alisa A Shaimardanova , Daria S Chulpanova , Valeriya V Solovyeva 1, Shaza S Issa , Aysilu I Mullagulova , Angelina A Titova , Yana O Mukhamedshina , Anna V Timofeeva , Alexander M Aimaletdinov , Islam R Nigmetzyanov , Albert A Rizvanov

Journal: Neural Regen Res .

PubMed ID: 37488869

Doi: 10.4103/1673-5374.375328

Products & Services: Gene Synthesis

Minimalist Nanovaccine with Optimized Amphiphilic Copolymers for Cancer Immunotherapy

Authors: Le Niu , Yu Miao , Zhiqin Cao , Ting Wei , Jiafei Zhu , Maoyi Li , Boxiong Bai , Linfu Chen , Nanhui Liu , Feng Pan , Junjie Zhu , Cheng Wang , Yang Yang , Qian Chen

Journal: ACS Nano .

PubMed ID: 38230639

Doi: 10.1021/acsnano.3c10174

Products & Services: Peptide Synthesis

Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide

Authors: Tian Xie , Feitong Dong , Gongshe Han , Xinyue Wu , Peng Liu , Zike Zhang , Jianlong Zhong , Somashekarappa Niranjanakumari , Kenneth Gable , Sita D Gupta , Wenchen Liu , Peter J Harrison , Dominic J Campopiano , Teresa M Dunn , Xin Gong

Journal: Cell Rep .

PubMed ID: 38285738

Doi: 10.1016/j.celrep.2024.113717

Products & Services: Proteins, Expression, Isolation and Analysis

Supramolecular Hydrogel with Ultra-Rapid Cell-Mediated Network Adaptation for Enhancing Cellular Metabolic Energetics and Tissue Regeneration

Authors: Zhuo Li, Boguang Yang, Zhengmeng Yang, Xian Xie, Zhengnan Guo, Jianyang Zhao, Ruinan Wang, Hao Fu, Pengchao Zhao, Xin Zhao, Guosong Chen, Gang Li, Fuxin Wei, Liming Bian

Journal: Adv Mater .

PubMed ID: 38295393

Doi: 10.1002/adma.202307176

Products & Services: Peptide Synthesis

TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing

Authors: Kostantin Kiianitsa, Maria E Lukes, Brian J Hayes, Julianna Brutman, Paul N Valdmanis, Thomas D Bird, Wendy H Raskind, Olena Korvatska

Journal: Brain

PubMed ID: 38226698

Doi: 10.1093/brain/awae014

Products & Services: Gene Synthesis Mutagenesis Services Plasmid DNA Preparation

mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer

Authors: No-Joon Song, Karthik B Chakravarthy, Hyeongseon Jeon, Chelsea Bolyard, Kelsi Reynolds, Kevin P Weller, Sarah Reisinger, Yi Wang, Anqi Li, Sizun Jiang, Qin Ma, Dan H Barouch, Mark P Rubinstein, Peter G Shields, Eugene M Oltz, Dongjun Chung, Zihai Li

Journal: J Immunother Cancer

PubMed ID: 38177076

Doi: 10.1136/jitc-2023-007922

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Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis

Authors: Xiao-Yu Ji, Yu-Xin Guo, Li-Bin Wang, Wen-Cheng Wu, Jia-Qi Wang, Jin He, Rui Gao, Javad Rasouli, Meng-Yuan Gao, Zhen-Hai Wang, Dan Xiao, Wei-Feng Zhang, Bogoljub Ciric, Yuan Zhang, Xing Li

Journal: J Neuroinflammation

PubMed ID: 38246987

Doi: 10.1186/s12974-024-03019-5

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A CRISPR-Cas12a-based electrochemical biosensor for the detection of microphthalmia-associated transcription factor

Authors: Qisheng Luo, Chunyuan Zhang, Xiandong Deng, Dongyuan Liu, Xingchen Pan, Yuanxun Gong, Qianli Tang, Kai Zhang, Xianjiu Liao

Journal: Mikrochim Acta

PubMed ID: 38170285

Doi: 10.1007/s00604-023-06164-5

Products & Services: Custom DNA/RNA Oligos

Cognitive impairment is associated with BDNF-TrkB signaling mediating synaptic damage and reduction of amino acid neurotransmitters in heart failure

Authors: Lei Wang, Ziwen Lu, Yu Teng, Weibing Pan, Yang Li, Sha Su, Jingling Chang, Mingjing Zhao

Journal: FASEB J

PubMed ID: 38085181

Doi: 10.1096/fj.202301699RR

Products & Services: Proteins, Expression, Isolation and Analysis

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

Authors: Chia Ying Huang, Alexander Metz, Roland Lange, Nadia Artico, Céline Potot, Julien Hazemann, Manon Müller, Marina Dos Santos, Alain Chambovey, Daniel Ritz, Deniz Eris, Solange Meyer, Geoffroy Bourquin, May Sharpe, Aengus Mac Sweeney

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 38289714

Doi: 10.1107/S2059798324000329

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis of prostaglandin efflux by MRP4

Authors: Sergei Pourmal, Evan Green, Ruchika Bajaj, Ilan E Chemmama, Giselle M Knudsen, Meghna Gupta, Andrej Sali, Yifan Cheng, Charles S Craik, Deanna L Kroetz, Robert M Stroud

Journal: Nat Struct Mol Biol

PubMed ID: 38216659

Doi: 10.1038/s41594-023-01176-4

Products & Services: Mutant Libraries

Beta-1,3-Glucan-Binding Protein Inhibits Dengue and ZIKA Virus Replication

Authors: Xiaoxue Xie, Di Wang, Bo Li, Guorui Liang, Xiaoli Chen, Dan Xing, Teng Zhao, Xinyu Zhou, Chunxiao Li

Journal: Biomedicines

PubMed ID: 38255195

Doi: 10.3390/biomedicines12010088

Products & Services: DNA Sequencing

Increasing the Pentose Phosphate Pathway Flux to Improve Plasmid DNA Production in Engineered

Authors: Mitzi de la Cruz, Flavio Kunert, Hilal Taymaz-Nikerel, Juan-Carlos Sigala, Guillermo Gosset, Jochen Büchs, Alvaro R Lara

Journal: Microorganisms

PubMed ID: 38257977

Doi: 10.3390/microorganisms12010150

Products & Services: Molecular Biology Reagents

Identification and application of an exocarp-preferential promoter for genetic engineering of tomato fruit

Authors: Xue-Ming Ruan, Xiangyu Xiong, Jian-Feng Li

Journal: Hortic Res

PubMed ID: 38544552

Doi: 10.1093/hr/uhae035

Products & Services: Catalog Antibody

Cluster-Enhanced Nanopore Sensing of Ovarian Cancer Marker Peptides in Urine

Authors: Thomas W Rockett, Mohammed Almahyawi, Madhav L Ghimire, Aashna Jonnalagadda, Victoria Tagliaferro, Sarah J Seashols-Williams, Massimo F Bertino, Gregory A Caputo, Joseph E Reiner

Journal: ACS Sens

PubMed ID: 38286995

Doi: 10.1021/acssensors.3c02207

Products & Services: Catalog Peptides

Combined biolistic and cell penetrating peptide delivery for the development of scalable intradermal DNA vaccines

Authors: Roizza Beth So, Gang Li, Victoria Brentville, Janet M Daly, James E Dixon

Journal: J Control Release

PubMed ID: 38244841

Doi: 10.1016/j.jconrel.2024.01.031

Products & Services: Proteins, Expression, Isolation and Analysis

Therapeutic effect of long-acting FGF21 with controlled site-specific modification on nonalcoholic steatohepatitis

Authors: Jianying Qi, Zhimou Guo, Shenglong Zhu, Xuan Jiang, Yuanyuan Wu, Yingli Chen, Fei Hu, Jingjing Xiong, YunZhou Wu, Xianlong Ye, Xinmiao Liang

Journal: Int J Biol Macromol

PubMed ID: 38290625

Doi: 10.1016/j.ijbiomac.2024.129797

Products & Services: Molecular Biology Reagents

Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies

Authors: Ester Blanco, Noelia Silva-Pilipich, Ana Bocanegra, Luisa Chocarro, Antonio Procopio, Karina Ausín, Joaquín Fernandez-Irigoyen, Leticia Fernández, Nerea Razquin, Ana Igea, Maider Garnica, Miriam Echaide, Hugo Arasanz, Ruth Vera, David Escors, Cristian Smerdou, Grazyna Kochan

Journal: Br J Cancer

PubMed ID: 38195888

Doi: 10.1038/s41416-023-02561-y

Products & Services: Molecular Biology Reagents

Glyoxylate reductase: Definitive identification in human liver mitochondria, its importance for the compartment-specific detoxification of glyoxylate

Authors: Sander F Garrelfs, Serhii Chornyi, Heleen Te Brinke, Jos Ruiter, Jaap Groothoff, Ronald J A Wanders

Journal: J Inherit Metab Dis

PubMed ID: 38200664

Doi: 10.1002/jimd.12711

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Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Authors: Giuseppe Rospo, Rosaria Chilà, Vittoria Matafora, Veronica Basso, Simona Lamba, Alice Bartolini, Angela Bachi, Federica Di Nicolantonio, Anna Mondino, Giovanni Germano, Alberto Bardelli

Journal: Genome Med

PubMed ID: 38243308

Doi: 10.1186/s13073-023-01275-3

Products & Services: Proteins, Expression, Isolation and Analysis

Hepatitis C virus E1 recruits high-density lipoprotein to support infectivity and evade antibody recognition

Authors: Jennifer Casiano Matos, Kaneemozhe Harichandran, Jingrong Tang, Denis O Sviridov, Giacomo Sidoti Migliore, Motoshi Suzuki, Lisa R Olano, Alvaro Hobbs, Ashish Kumar, Myeisha U Paskel, Mattia Bonsignori, Altaira D Dearborn, Alan T Remaley, Joseph Marcotrigiano

Journal: J Virol

PubMed ID: 38174935

Doi: 10.1128/jvi.00849-23

Products & Services: Proteins, Expression, Isolation and Analysis

The lncRNA HCG4 regulates the RIG-I-mediated IFN production to suppress H1N1 swine influenza virus replication

Authors: Jinghua Cheng, Jie Tao, Benqiang Li, Ying Shi, Huili Liu

Journal: Front Microbiol

PubMed ID: 38274760

Doi: 10.3389/fmicb.2023.1324218

Products & Services: Proteins, Expression, Isolation and Analysis

Predicting multiple conformations via sequence clustering and AlphaFold2

Authors: Hannah K Wayment-Steele, Adedolapo Ojoawo, Renee Otten, Julia M Apitz, Warintra Pitsawong, Marc Hömberger, Sergey Ovchinnikov, Lucy Colwell, Dorothee Kern

Journal: Nature

PubMed ID: 37956700

Doi: 10.1038/s41586-023-06832-9

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N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting

Authors: Thomas E Mulroney, Tuija Pöyry, Juan Carlos Yam-Puc, Maria Rust, Robert F Harvey, Lajos Kalmar, Emily Horner, Lucy Booth, Alexander P Ferreira, Mark Stoneley, Ritwick Sawarkar, Alexander J Mentzer, Kathryn S Lilley, C Mark Smales, Tobias von der Haar, Lance Turtle, Susanna Dunachie, Paul Klenerman, James E D Thaventhiran, Anne E Willis

Journal: Nature

PubMed ID: 38057663

Doi: 10.1038/s41586-023-06800-3

Products & Services: PCR Cloning and Subcloning

Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

Authors: Rajeshwer S Sankhala , Kerri G Lal , Jaime L Jensen , Vincent Dussupt , Letzibeth Mendez-Rivera , Hongjun Bai , Lindsay Wieczorek , Sandra V Mayer , Michelle Zemil , Danielle A Wagner , Samantha M Townsley , Agnes Hajduczki , William C Chang , Wei-Hung Chen , Gina C Donofrio , Ningbo Jian , Hannah A D King , Cynthia G Lorang , Elizabeth J Martinez , Phyllis A Rees , Caroline E Peterson , Fabian Schmidt , Tricia J Hart , Debra K Duso , Lawrence W Kummer , Sean P Casey , Jazmean K Williams , Shruthi Kannan , Bonnie M Slike , Lauren Smith , Isabella Swafford , Paul V Thomas , Ursula Tran , Jeffrey R Currier , Diane L Bolton , Edgar Davidson , Benjamin J Doranz , Theodora Hatziioannou , Paul D Bieniasz , Dominic Paquin-Proulx , William W Reiley , Morgane Rolland , Nancy J Sullivan , Sandhya Vasan , Natalie D Collins , Kayvon Modjarrad , Gregory D Gromowski , Victoria R Polonis , Nelson L Michael , Shelly J Krebs , M Gordon Joyce

Journal: Nat Commun

PubMed ID: 38172512

Doi: 10.1038/s41467-023-44265-0.

Products & Services: Antibody Modification and Purification Services

Therapeutic vaccination with lentiviral vector in HBV-persistent mice and two inactive HBsAg carriers

Authors: Yumeng Zhang, Maryline Bourgine , Yanmin Wan, Jieyu Song, Zongying Li, Yiqi Yu, Wangfang Jiang, Mingzhe Zhou, Cuiyuan Guo, Didier Santucci, Xiao Liang, Christian Brechot, Wenhong Zhang, Pierre Charneau, Hong Wu, Chao Qiu

Journal: Hepatology

PubMed ID: 37827470

Doi: 10.1016/j.jhep.2023.09.019

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A new antibiotic traps lipopolysaccharide in its intermembrane transporter

Authors: Karanbir S Pahil, Morgan S A Gilman, Vadim Baidin, Thomas Clairfeuille, Patrizio Mattei, Christoph Bieniossek, Fabian Dey, Dieter Muri, Remo Baettig, Michael Lobritz, Kenneth Bradley, Andrew C Kruse 4, Daniel Kahne 5

Journal: Nature

PubMed ID: 38172635

Doi: 10.1038/s41586-023-06799-7

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Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution

Authors: Jason Z. Zhang, William H. Nguyen, Nathan Greenwood, John C. Rose, Shao-En Ong, Dustin J. Maly & David Baker

Journal: Nature Biotechnol

PubMed ID: 38228150

Doi: 10.1038/s41587-023-02107-w

Products & Services: Plasmid DNA Preparation

Structure-guided discovery of anti-CRISPR and anti-phage defense proteins

Authors: Ning Duan , Emily Hand , Mannuku Pheko , Shikha Sharma , Akintunde Emiola

Journal: Nat Commun

PubMed ID: 38245560

Doi: 10.1038/s41467-024-45068-7

Products & Services: Codon Optimization

Stabilization of the Metastable Pre-Fusion Conformation of the SARS-CoV-2 Spike Glycoprotein through N-Linked Glycosylation of the S2 Subunit

Authors: Fuwen Zan, Yao Zhou, Ting Chen , Yahan Chen, Zhixia Mu, Zhaohui Qian , Xiuyuan Ou

Journal: Viruses.

PubMed ID: 38399999

Doi: 10.3390/v16020223

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Modulations in the host cell proteome by the hantavirus nucleocapsid protein

Authors: Austin Royster, Songyang Ren, Saima Ali, Sheema Mir, Mohammad Mir

Journal: PLoS Pathog

PubMed ID: 38190410

Doi: 10.1371/journal.ppat.1011925

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A label-free high-throughput protein solubility assay and its application to Aβ40

Authors: Max Lindberg, Emil Axell, Emma Sparr, Sara Linse

Journal: Biophys Chem

PubMed ID: 38309218

Doi: 10.1016/j.bpc.2023.107165

Products & Services: Molecular Biology Reagents

Identification of a novel B-cell epitope of the African swine fever virus p34 protein and development of an indirect ELISA for the detection of serum antibodies

Authors: Yuanyuan Tian, Chao Liang, Jingming Zhou, Fanglin Sun, Yankai Liu, Yumei Chen, Xifang Zhu, Hongliang Liu, Peiyang Ding, Enping Liu, Ying Zhang, Sixuan Wu, Aiping Wang

Journal: Front Microbiol

PubMed ID: 38282734

Doi: 10.3389/fmicb.2023.1308753

Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription

Authors: Qian Zhang, Wantae Kim, Svetlana Panina, Joshua E Mayfield, Bede Portz, Y Jessie Zhang

Journal: biorxiv

PubMed ID: 38260389

Doi: 10.1101/2024.01.01.573828

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Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma

Authors: Gagan Chhabra, Chandra K Singh, Mary A Ndiaye, Shengqin Su, Carl A Shirley, Nihal Ahmad

Journal: NPJ Precis Oncol

PubMed ID: 38184733

Doi: 10.1038/s41698-023-00493-7

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Mining and rational design of psychrophilic catalases using metagenomics and deep learning models

Authors: Shuning Wu, Guoshun Xu, Yongping Su, Huoqing Huang, Xinxin Xu, Yuhong Zhang, Jian Tian, Wei Zhang, Zhiwei Zhang, Bo Liu

Journal: Appl Microbiol Biotechnol

PubMed ID: 38175233

Doi: 10.1007/s00253-023-12926-1

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S100A12 protein as a porcine health status biomarker when quantified in saliva samples

Authors: A M Gutiérrez, M Matas-Quintanilla, M Piñeiro, J Sánchez, P Fuentes, F J Ibáñez-López

Journal: Vet J

PubMed ID: 38215874

Doi: 10.1016/j.tvjl.2024.106062

Products & Services: Proteins, Expression, Isolation and Analysis

A high catalytic efficiency and chemotolerant formate dehydrogenase from Bacillus simplex

Authors: Rattima Boonkumkrong, Paweenapon Chunthaboon, Pobthum Munkajohnpong, Pratchaya Watthaisong, Panu Pimviriyakul, Somchart Maenpuen, Pimchai Chaiyen, Ruchanok Tinikul

Journal: Biotechnol J

PubMed ID: 38180313

Doi: 10.1002/biot.202300330

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Sast1-mediated manifold effects inhibit Plutella xylostella fertility

Authors: Min-Hui Cao, Ming-Min Zou, Li-Li Liu, Shi-Jie Dong, Meng-Qi Huang, Jun-Hao Zheng, Ruo-Nan Li, Jin-Dong Cui, Lu Peng

Journal: Pest Manag Sci

PubMed ID: 38252701

Doi: 10.1002/ps.7966

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Self-cascade deoxynivalenol detoxification by an artificial enzyme with bifunctions of dehydrogenase and aldo/keto reductase from genome mining

Authors: Jiafeng Niu, Ruxue Yan, Huimin Zhou, Bin Ma, Zhaoxin Lu, Fanqiang Meng, Fengxia Lu, Ping Zhu

Journal: Int J Biol Macromol

PubMed ID: 38246466

Doi: 10.1016/j.ijbiomac.2024.129512

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VEGF-delivering PEG hydrogels promote vascularization in the porcine subcutaneous space

Authors: Michelle J Quizon, Juline N Deppen, Graham F Barber, Pranav P Kalelkar, María M Coronel, Rebecca D Levit, Andres J Garcia

Journal: J Biomed Mater Res A

PubMed ID: 38189109

Doi: 10.1002/jbm.a.37666

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Nitrated T cell epitope linked vaccine targeting CD47 elicits antitumor immune responses and acts synergistically with vaccine targeting PDL1

Authors: Danni Deng, Guozhi Li, Xuefei Xia, Shuyang Xu, Le Gao, Li Zhang, Wenbing Yao, Hong Tian, Xiangdong Gao

Journal: Int Immunopharmacol

PubMed ID: 38181672

Doi: 10.1016/j.intimp.2023.111374

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FS145, the first flea-derived disintegrin, inhibits angiogenesis through specifically binding integrin αβ

Authors: Wancheng Lu, Zhijian Xiao, Hang Liao, Jianpeng Xie, Yihan Gao, Weichen Xiong, Qingye Zeng, Zhenhui Deng, Jiena Wu, Jinwei Chai, Xin Chen, Xueqing Xu

Journal: Int J Biol Macromol

PubMed ID: 38211910

Doi: 10.1016/j.ijbiomac.2024.129289

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Development of nanobodies specific to clumping factors A of Staphylococcus aureus by yeast surface display

Authors: Meng Mei, Mengqing Lu, Shiqi Li, Xinyi Ren, Banbin Xing, Yang Hu, Yuqi Wu, Huan Chen, Longhao Wang, Li Yi, Ke Ming, Zigong Wei

Journal: Int J Biol Macromol

PubMed ID: 38185298

Doi: 10.1016/j.ijbiomac.2024.129208

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Immunogenicity studies of recombinant RBD SARS-CoV-2 as a COVID-19 vaccine candidate produced in

Authors: Intan Aghniya Safitri, Yovin Sugijo, Fernita Puspasari, Fifi Fitriyah Masduki, Ernawati Arifin Giri-Rachman, Aluicia Anita Artarini, Marselina Irasonia Tan, Dessy Natalia

Journal: Vaccine X

PubMed ID: 38304876

Doi: 10.1016/j.jvacx.2024.100443

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Genetic engineering employing MPB70 and its promoter enables efficient secretion and expression of foreign antigen in bacillus Calmette Guérin (BCG) Tokyo

Authors: Atsuki Takeishi, Amina K Shaban, Taichi Kakihana, Hayato Takihara, Shujiro Okuda, Hidekazu Osada, Desak Nyoman Surya Suameitria Dewi, Yuriko Ozeki, Yutaka Yoshida, Akihito Nishiyama, Yoshitaka Tateishi, Yuki Aizu, Yasushi Chuma, Kazuyo Onishi, Daisuke Hayashi, Saburo Yamamoto, Tetsu Mukai, Manabu Ato, Duong Huu Thai, Huynh Thi Thao Nhi, Tsuyoshi Shirai, Satoshi Shibata, Fumiko Obata, Jun Fujii, Seiya Yamayoshi, Maki Kiso, Sohkichi Matsumoto

Journal: Microbiol Immunol

PubMed ID: 38294180

Doi: 10.1111/1348-0421.13116

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Studying the topology of peroxisomal acyl-CoA synthetases using self-assembling split sfGFP

Authors: Serhii Chornyi, Janet Koster, Lodewijk IJlst, Hans R Waterham

Journal: Histochem Cell Biol

PubMed ID: 38243092

Doi: 10.1007/s00418-023-02257-7

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Performance Analysis of Serodiagnostic Tests to Characterize the Incline and Decline of the Individual Humoral Immune Response in COVID-19 Patients: Impact on Diagnostic Management

Authors: Ronald von Possel, Babett Menge, Christina Deschermeier, Carlos Fritzsche, Christoph Hemmer, Hilte Geerdes-Fenge, Micha Loebermann, Anette Schulz, Erik Lattwein, Katja Steinhagen, Ralf Tönnies, Reiner Ahrendt, Petra Emmerich

Journal: Viruses

PubMed ID: 38257792

Doi: 10.3390/v16010091

Products & Services: Proteins, Expression, Isolation and Analysis

Generation and Application of Monoclonal Antibodies against Porcine S100A8, S100A9, and S100A12 Proteins Using Hybridoma Technology

Authors: Pengpeng Xia, Xin Ma, Li Yan, Siqi Lian, Xiangyu Li, Yi Luo, Ziyue Chen, Xingduo Ji

Journal: Int J Mol Sci

PubMed ID: 38256103

Doi: 10.3390/ijms25021029

Products & Services: Proteins, Expression, Isolation and Analysis

A Non-Functional Carbon Dioxide-Mediated Post-Translational Modification on Nucleoside Diphosphate Kinase of

Authors: Harry G Gannon, Amber Riaz-Bradley, Martin J Cann

Journal: Int J Mol Sci

PubMed ID: 38255974

Doi: 10.3390/ijms25020898

Products & Services: Proteins, Expression, Isolation and Analysis

Role of Histiocyte-Derived frHMGB1 as a Facilitator in Non-Canonical Pyroptosis of Monocytes/Macrophages in Lethal Sepsis

Authors: Yu Tian, Yuwen Cao, Fang Liu, Lin Xia, Chao Wang, Zhaoliang Su

Journal: J Infect Dis

PubMed ID: 38243905

Doi: 10.1093/infdis/jiae020

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Chimeric proteins of Mycoplasma hyopneumoniae as vaccine and preclinical model for immunological evaluation

Authors: Marcus Rebouças Santos, Leonardo Teófilo Toledo, Ênio José Bassi, Wagnner José Nascimento Porto, Gustavo Costa Bressan, Maria Aparecida S Moreira, Yung-Fu Chang, Abelardo Silva-Júnior

Journal: Braz J Microbiol

PubMed ID: 38217795

Doi: 10.1007/s42770-023-01240-7

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Electrically silent KvS subunits associate with native Kv2 channels in brain and impact diverse properties of channel function

Authors: Michael Ferns, Deborah van der List, Nicholas C Vierra, Taylor Lacey, Karl Murray, Michael Kirmiz, Robert G Stewart, Jon T Sack, James S Trimmer

Journal: biorxiv

PubMed ID: 38328147

Doi: 10.1101/2024.01.25.577135

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Recombinant T7 RNA polymerase production using ClearColi BL21(DE3) and animal-free media for in vitro transcription

Authors: Qianying Liang, Bowen Tu, Lun Cui

Journal: Appl Microbiol Biotechnol

PubMed ID: 38180552

Doi: 10.1007/s00253-023-12939-w

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Astragaloside IV regulates circ_0001615 and miR-873-5p/LASP1 axis to suppress colorectal cancer cell progression

Authors: Pengfei Kong, Xuemei Tang, Fang Liu, Xuegui Tang

Journal: Chem Biol Drug Des

PubMed ID: 38230773

Doi: 10.1111/cbdd.14423

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Prevalence of IgG antibodies against Malawi polyomavirus in patients with autoimmune diseases and lymphoproliferative disorders subjected to bone marrow transplantation

Authors: Jérôme T J Nicol, Elisa Mazzoni, Maria Rosa Iaquinta, Raffaella De Pace, Pauline Gaboriaud, Natalia Maximova, Carolina Cason, Eleonora De Martino, Chiara Mazziotta, Pierre Coursaget, Antoine Touzé, Valentina Boz, Manola Comar, Mauro Tognon, Fernanda Martini

Journal: Front Immunol

PubMed ID: 38299147

Doi: 10.3389/fimmu.2023.1293313

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Evolutionary preservation of CpG dinucleotides in RAG1 may elucidate the relatively high rate of methylation-mediated mutagenesis of RAG1 transposase

Authors: Mariam M Fawzy, Maiiada H Nazmy, Azza A K El-Sheikh, Moustafa Fathy

Journal: Immunol Res

PubMed ID: 38240953

Doi: 10.1007/s12026-023-09451-8

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Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells

Authors: Lijun Ye , Dongdong Zhao , Ju Li , Yiran Wang , Bo Li , Yuanzhao Yang , Xueting Hou , Huibin Wang , Zhandong Wei , Xiaoqi Liu , Yaqiu Li, Siwei Li , Yajing Liu , Xueli Zhang , Changhao Bi

Journal: Nat Biotechnol .

PubMed ID: 38168994

Doi: 10.1038/s41587-023-02050-w

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Cross-feeding promotes heterogeneity within yeast cell populations

Authors: Kevin K Y Hu, Ankita Suri, Geoff Dumsday, Victoria S Haritos

Journal: Nat Commun

PubMed ID: 38200012

Doi: 10.1038/s41467-023-44623-y

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Cyclic di-GMP inhibits nitrate assimilation by impairing the antitermination function of NasT in Pseudomonas putida

Authors: Liang Nie, Yujie Xiao, Tiantian Zhou, Haoqi Feng, Meina He, Qingyuan Liang, Kexin Mu, Hailing Nie, Qiaoyun Huang, Wenli Chen

Journal: Nucleic Acids Res

PubMed ID: 38000372

Doi: 10.1093/nar/gkad1117

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Impact of surface receptors TLR2, CR3, and FcγRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages

Authors: Bibiana Petri da Silveira , Rola Barhoumi , Jocelyne M Bray , Hannah M Cole-Pfeiffer , Cory J Mabry , Robert C Burghardt , Noah D Cohen, Angela I Bordin

Journal: Immunity

PubMed ID: 38018994

Doi: 10.1128/iai.00383-23

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The HIV capsid mimics karyopherin engagement of FG-nucleoporins

Authors: C. F. Dickson, S. Hertel, A. J. Tuckwell, N. Li, J. Ruan, S. C. Al-Izzi, N. Ariotti, E. Sierecki, Y. Gambin, R. G. Morris, G. J. Towers, T. Böcking & D. A. Jacques

Journal: Nature

PubMed ID: 38267582

Doi: 10.1038/s41586-023-06969-7

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The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus

Authors: Yingying Guo , Songyue Wu , Wenting Li , Haonan Yang , Tianhao Shi , Bin Ju , Zheng Zhang , Renhong Yan

Journal: Nat Commun

PubMed ID: 38280880

Doi: 10.1038/s41467-024-45202-5

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Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

Authors: Eike-Christian Wamhoff , Larance Ronsard , Jared Feldman , Grant A Knappe , Blake M Hauser , Anna Romanov , James Brett Case , Shilpa Sanapala , Evan C Lam , Kerri J St Denis , Julie Boucau , Amy K Barczak , Alejandro B Balazs , Michael S Diamond , Aaron G Schmidt , Daniel Lingwood , Mark Bathe

Journal: Nat Commun

PubMed ID: 38291019

Doi: 10.1038/s41467-024-44869-0

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Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy

Authors: Binh An Nguyen , Virender Singh , Shumaila Afrin , Anna Yakubovska , Lanie Wang , Yasmin Ahmed , Rose Pedretti , Maria Del Carmen Fernandez-Ramirez , Preeti Singh , Maja Pękała , Luis O Cabrera Hernandez , Siddharth Kumar , Andrew Lemoff , Roman Gonzalez-Prieto , Michael R Sawaya , David S Eisenberg , Merrill Douglas Benson , Lorena Saelices

Journal: Nat Commun

PubMed ID: 38233397

Doi: 10.1038/s41467-024-44820-3

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STYXL1 regulates CCT complex assembly and flagellar tubulin folding in sperm formation

Authors: Yu Chen , Mengjiao Luo , Haixia Tu , Yaling Qi , Yueshuai Guo , Xiangzheng Zhang , Yiqiang Cui , Mengmeng Gao , Xin Zhou , Tianyu Zhu , Hui Zhu , Chenghao Situ , Yan Li , Xuejiang Guo

Journal: Nat Commun

PubMed ID: 38168070

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Cryo-EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH

Authors: Niraj Kumar , Shivani Sharma , Prem S Kaushal

Journal: Nat Commun

PubMed ID: 38245551

Doi: 10.1038/s41467-024-44879-y

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Biomimetic Control over Bimetallic Nanoparticle Structure and Activity via Peptide Capping Ligand Sequence

Authors: Maichong Xie, Ryuichi Shimogawa, Yang Liu, Lihua Zhang, Alexandre C. Foucher, Prahlad K. Routh, Eric A. Stach, Anatoly I. Frenkel*, and Marc R. Knecht

Journal: ACS Nano

PubMed ID: 38227802

Doi: 10.1021/acsnano.3c10016

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Single-Molecule Analysis of SARS-CoV-2 Double-Stranded Polynucleotides Using Solid-State Nanopore with AI-Assisted Detection and Classification: Implications for Understanding Disease Severity

Authors: Ibrar Alam, Thitikorn Boonkoom, Harit Pitakjakpipop, Poramin Boonbanjong, Kawin Loha, Thanaya Saeyang, Jarunee Vanichtanankul, Deanpen Japrung

Journal: ACS Appl Bio Mater

PubMed ID: 38194666

Doi: 10.1021/acsabm.3c00998

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A general platform for targeting MHC-II antigens via a single loop

Authors: Haotian Du, Jingjia Liu, Kevin M Jude, Xinbo Yang, Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Ali Mobedi, Udit Parekh, R Andres Parra Sperberg, Jean-Philippe Julien, Elizabeth D Mellins, K Christopher Garcia, Po-Ssu Huang

Journal: biorxiv

PubMed ID: 38352315

Doi: 10.1101/2024.01.26.577489

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PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease

Authors: Guangyu Zhou, Chen Zhang, Hui Peng, Xuesong Su, Qun Huang, Zixia Zhao, Guangyi Zhao

Journal: Mol Med

PubMed ID: 38200452

Doi: 10.1186/s10020-023-00759-7

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Structural insights into the activation and inhibition of CXC chemokine receptor 3

Authors: Haizhan Jiao, Bin Pang, Aijun Liu, Qiang Chen, Qi Pan, Xiankun Wang, Yunong Xu, Ying-Chih Chiang, Ruobing Ren, Hongli Hu

Journal: Nat Struct Mol Biol

PubMed ID: 38177682

Doi: 10.1038/s41594-023-01175-5

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Structural biases in disordered proteins are prevalent in the cell

Authors: David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse, Shahar Sukenik

Journal: Nat Struct Mol Biol

PubMed ID: 38177684

Doi: 10.1038/s41594-023-01148-8

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Response to COVID-19 vaccination in patients on cancer therapy: Analysis in a SARS-CoV-2-naïve population

Authors: George Cavic, Andrew A Almonte, Sarah M Hicks, Teresa Neeman, Jo-Wai Wang, Sue Brew, Philip Y Choi, Ian Cockburn, Elizabeth E Gardiner, Desmond Yip, Aude M Fahrer, Yada Kanjanapan

Journal: Asia Pac J Clin Oncol

PubMed ID: 38221764

Doi: 10.1111/ajco.14047

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PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial

Authors: Francisco J Martinez, Michael White, Micheline Guillotte-Blisnick, Christèle Huon, Alix Boucharlat, Fabrice Agou, Patrick England, Jean Popovici, Mimi M Hou, Sarah E Silk, Jordan R Barrett, Carolyn M Nielsen, Jenny M Reimer, Paushali Mukherjee, Virander S Chauhan, Angela M Minassian, Simon J Draper, Chetan E Chitnis

Journal: npj Vaccines

PubMed ID: 38184681

Doi: 10.1038/s41541-023-00796-7

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Comparative Study on the Immunogenicity of COVID-19 mRNA Vaccines in Patients Receiving Adjuvant and Palliative Chemotherapy

Authors: Hyun-Woo Choi, Younggon Jung, Uh Jin Kim, Sang-Cheol Lee, Jung Hye Kwon, Hyeonjong Kim, Sarah Kim, Yoonjung Lee, Hyun-Jung Shim, Sang-Hee Cho, Ik-Joo Chung, Eu Chang Hwang, Seung Ji Kang, Woo Kyun Bae, Seung-Jung Kee

Journal: Chonnam Med J

PubMed ID: 38304127

Doi: 10.4068/cmj.2024.60.1.69

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Up-regulation of lncRNA WT1-AS ameliorates Aβ-stimulated neuronal injury through modulation of miR-186-5p/CCND2 axis in Alzheimer's disease

Authors: Yun Tang, Xiaojiu Zhang, Shihui Wang, Lu Liu, Qing Wang, Yufeng Liu, Yadong Yu, Qijin Zhai

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 38372094

Doi: 10.14715/cmb/2024.70.1.27

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Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Antitumor Activity of CD8+ T Cells

Authors: Chuwen Li, Haiyan Guo, Peisong Zhai, Ming Yan, Chun Liu, Xiaoning Wang, Chaoji Shi, Jiang Li, Tong Tong, Zhiyuan Zhang, Hailong Ma, Jianjun Zhang

Journal: Cancer Res

PubMed ID: 37930937

Doi: 10.1158/0008-5472.CAN-23-1448

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Toxicity Assessment of Mixed Exposure of Nine Perfluoroalkyl Substances at Concentrations Relevant to Daily Intake

Authors: Kazuki Takeda, Taki Saito, Sakura Sasaki, Akifumi Eguchi, Makoto Sugiyama, Saeka Eto, Kio Suzuki, Ryo Kamata

Journal: Toxics

PubMed ID: 38251008

Doi: 10.3390/toxics12010052

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Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia

Authors: Wenhua Jiang, Qiangqiang Hou, Hongrui Xu, Kexin Yang, Xiaohui Wang, Kuojun Zhang, Yi Zeng, Wenqiang Li, Bingrui Wang, Guangmei Luo, Xiaofan Zhao, Hui Shen, Yong Xu, Xiaoxing Wu

Journal: J Med Chem

PubMed ID: 38175809

Doi: 10.1021/acs.jmedchem.3c02104

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Local Multiple-site Injections of a Plasmid Encoding Human Mitigate Radiation-induced Skin Injury by Inhibiting Ferroptosis

Authors: Xiaoying Wang, Yuxin Lu, Xiaochen Cheng, Xuefeng Zhu, Dujuan Li, Haiying Duan, Shenhui Hu, Fengjun Xiao, Li Du, Qinglin Zhang

Journal: Curr Drug Deliv

PubMed ID: 37157191

Doi: 10.2174/1567201820666230508120720

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Bioactive Polyurethane-Poly(ethylene Glycol) Diacrylate Hydrogels for Applications in Tissue Engineering

Authors: Yixuan Yuan, Caleb Tyson, Annika Szyniec, Samuel Agro, Tara N Tavakol, Alexander Harmon, DessaRae Lampkins, Lauran Pearson, Jerald E Dumas, Lakeshia J Taite

Journal: Gels

PubMed ID: 38391438

Doi: 10.3390/gels10020108

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Enhanced immunogenicity and protective efficacy in mice following a Zika DNA vaccine designed by modulation of membrane-anchoring regions and its association to adjuvants

Authors: Franciane Mouradian Emidio Teixeira, Luana de Mendonça Oliveira, Anna Cláudia Calvielli Castelo Branco, Ricardo Wesley Alberca, Emanuella Sarmento Alho de Sousa, Bruno Henrique de Sousa Leite, Wenny Camilla Dos Santos Adan, Alberto José da Silva Duarte, Roberto Dias Lins, Maria Notomi Sato, Isabelle Freire Tabosa Viana

Journal: Front Immunol

PubMed ID: 38361945

Doi: 10.3389/fimmu.2024.1307546

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Inter-alpha-trypsin inhibitor (IαI) and hyaluronan modifications enhance the innate immune response to influenza virus in the lung

Authors: Fengying Tang, Stephen R Reeves, Jourdan E Brune, Mary Y Chang, Christina K Chan, Peter Waldron, Sheona P Drummond, Caroline M Milner, Kimberly M Alonge, Stavros Garantziotis, Anthony J Day, William A Altemeier, Charles W Frevert

Journal: Matrix Biol

PubMed ID: 38232913

Doi: 10.1016/j.matbio.2024.01.004

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In situ vaccination via tissue-targeted cDC1 expansion enhances the immunogenicity of chemoradiation and immunotherapy

Authors: Brandon Lam, Yu Jui Kung, John Lin, Ssu-Hsueh Tseng, Hsin-Fang Tu, Claire Huang, Brandon Lee, Esteban Velarde, Ya Chea Tsai, Rafael Villasmil, Sung Taek Park, Deyin Xing, Chien-Fu Hung, T-C Wu

Journal: J Clin Invest

PubMed ID: 37917174

Doi: 10.1172/JCI171621

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The naringenin-dependent regulator FdeR can be applied as a NIMPLY gate controlled by naringenin and arabinose

Authors: Fernanda Miyuki Kashiwagi, Brenno Wendler Miranda, Emanuel Maltempi de Souza, Marcelo Müller-Santos

Journal: Synth Biol (Oxf)

PubMed ID: 38249314

Doi: 10.1093/synbio/ysae001

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A Novel Role for the Adenovirus L4 Region 22K and 33K Proteins in Adeno-Associated Virus Production

Authors: Angela Adsero, Brendan Chestnut, Sara Shahnejat-Bushehri, Lalita Sasnoor, Travis McMurphy, Mike Swenor, Ryan Pasquino, Arun Pradhan, Victor Hernandez, Linas Padegimas, David Dismuke

Journal: Hum Gene Ther

PubMed ID: 38062776

Doi: 10.1089/hum.2023.146

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Cascaded amplifying circuit enables sensitive detection of fungal pathogens

Authors: Cong Fan, Nike He, Jifeng Yuan

Journal: Biosens Bioelectron

PubMed ID: 38281368

Doi: 10.1016/j.bios.2024.116058

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An inducible CRISPRi circuit for tunable dynamic regulation of gene expression in Saccharopolyspora erythraea

Authors: Xing Jiang, Xiang Ke, Xiwei Tian, Ju Chu

Journal: Biotechnol Lett

PubMed ID: 38279045

Doi: 10.1007/s10529-023-03462-z

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