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Shrimp injection with dsRNA targeting the microsporidian EHP polar tube protein reduces internal and external parasite amplification

Authors: Satika Yuanlae, Tharinthon Prasartset, Onrapak Reamtong, Natthinee Munkongwongsiri, Muthita Panphloi, Thanchanok Preechakul, Rungkarn Suebsing, Siripong Thitamadee, Anuphap Prachumwat, Ornchuma Itsathitphaisarn, Suparat Taengchaiyaphum, Chanadda Kasamechotchung

Journal: Sci Rep

PubMed ID: 38413745

Doi: 10.1038/s41598-024-55400-2

Products & Services: Molecular Biology Reagents

Rapid Decline of SARS-CoV-2 Viral Load in Single vs Double-Dose (Short-Interval <6 Weeks) ChAdOx nCoV-19 Vaccinated Health-Care Workers

Authors: Arnab Ghosh, Poonam Kanta, Manisha Ramola, Ritin Mohindra, Kapil Goyal, Roop Kishore, Vikas Suri, P V M Lakshmi, Chanderkanta Chauhan, Manisha Sharma, Partha Rakshit, Kalaiarasan Ponnusamy, Tanzin Dikid, Mini P Singh

Journal: Curr Microbiol

PubMed ID: 38353761

Doi: 10.1007/s00284-023-03603-7

Products & Services: Serology SARS-Cov-2 detection kits

Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8T cell function and its impact against pancreatic ductal adenocarcinoma

Authors: Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang, Xiangmin Tong

Journal: Oncoimmunology

PubMed ID: 38419758

Doi: 10.1080/2162402X.2024.2322173

Products & Services: PCR Cloning and Subcloning

Advances and Challenges in SARS-CoV-2 Detection: A Review of Molecular and Serological Technologies

Authors:

Journal: Diagnostics (Basel)

PubMed ID: 38472991

Doi: 10.3390/diagnostics14050519

Products & Services: Proteins, Expression, Isolation and Analysis

Residues within the LptC transmembrane helix are critical for Escherichia coli LptB FG ATPase regulation

Authors: Nicholas P Cina, Dara W Frank, Candice S Klug

Journal: Protein Sci

PubMed ID: 38131105

Doi: 10.1002/pro.4879

Products & Services: Proteins, Expression, Isolation and Analysis

Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

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Disordered regions mediate the interaction of p53 and MRE11

Authors: Sinem Usluer , Markus Galhuber , Yukti Khanna , Benjamin Bourgeois , Emil Spreitzer , Helene Michenthaler, Andreas Prokesch, Tobias Madl

Journal: Cell Research

PubMed ID: 38123020

Doi: 10.1016/j.bbamcr.2023.119654

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Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

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Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Authors: Xiaozhu Zhang, Briana Van Treeck, Connor A. Horton, Jeremy J. R. McIntyre, Sarah M. Palm, Justin L. Shumate & Kathleen Collins

Journal: Nat Biotechnol

PubMed ID: 38379101

Doi: 10.1038/s41587-024-02137-y

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Comprehensive Genomic Analysis Identifies a Diverse Landscape of Sideroblastic and Nonsideroblastic Iron-Related Anemias with Novel and Pathogenic Variants in an Iron-Deficient Endemic Setting

Authors: Pankaj Sharma, Prateek Bhatia, Minu Singh, Manu Jamwal, Swetha Pallavelangini, Reena Das, Pankaj Malhotra, Savita V Attri, Sarah Ducamp, Mark D Fleming, Amita Trehan

Journal: J Mol Diagn

PubMed ID: 38360212

Doi: 10.1016/j.jmoldx.2024.01.011

Products & Services: Molecular Biology Reagents

SARS-CoV-2 targets ribosomal RNA biogenesis

Authors: V Talya Yerlici, Audrey Astori, Nevraj S Kejiou, Chris A Jordan, Negin Khosraviani, Janet N Y Chan, Razqallah Hakem, Brian Raught, Alexander F Palazzo, Karim Mekhail

Journal: Cell Rep

PubMed ID: 38427561

Doi: 10.1016/j.celrep.2024.113891

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering recombinant replication-competent bluetongue viruses expressing reporter genes for and non-invasive studies

Authors: Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Alejandro Marín-López, Miguel Illescas-Amo, Germán Andrés, Eva Calvo-Pinilla, Gema Lorenzo, Piet A van Rijn, Javier Ortego, Aitor Nogales

Journal: Microbiol Spectr

PubMed ID: 38353566

Doi: 10.1128/spectrum.02493-23

Products & Services: Molecular Biology Reagents

Site-Directed Mutagenesis of VvCYP76F14 (Cytochrome P450) Unveils Its Potential for Selection in Wine Grape Varieties Linked to the Development of Wine Bouquet

Authors: Bin Peng, Jianguo Ran, Yiyang Li, Meiling Tang, Huilin Xiao, Shengpeng Shi, Youzheng Ning, Adeeba Dark, Jin Li, Xueqiang Guan, Zhizhong Song

Journal: J Agric Food Chem

PubMed ID: 38334101

Doi: 10.1021/acs.jafc.3c09083

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Applying valency-based immuno-selection to generate broadly cross-reactive antibodies against influenza hemagglutinins

Authors: Daniëla Maria Hinke, Ane Marie Anderson, Kirankumar Katta, Marlene Fyrstenberg Laursen, Demo Yemane Tesfaye, Ina Charlotta Werninghaus, Davide Angeletti, Gunnveig Grødeland, Bjarne Bogen, Ranveig Braathen

Journal: Nat Commun

PubMed ID: 38346952

Doi: 10.1038/s41467-024-44889-w

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Evaluation of the therapeutic effect of a novel bacteriophage in the healing process of infected wounds with Klebsiella pneumoniae in mice

Authors: Fatemeh Zeynali Kelishomi, Farhad Nikkhahi, Samira Amereh, Fatemeh Ghayyaz, Seyed Mahmoud Amin Marashi, Amir Javadi, Gholamhassan Shahbazi, Mohadeseh Khakpour

Journal: J Glob Antimicrob Resist

PubMed ID: 38307250

Doi: 10.1016/j.jgar.2024.01.018

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Structural and functional comparisons of salivary α-glucosidases from the mosquito vectors Aedes aegypti, Anopheles gambiae, and Culex quinquefasciatus

Authors: Adeline E Williams, Apostolos G Gittis, Karina Botello, Phillip Cruz, Ines Martin-Martin, Paola Carolina Valenzuela Leon, Benjamin Sumner, Brian Bonilla, Eric Calvo

Journal: Insect Biochem Mol Biol

PubMed ID: 38428508

Doi: 10.1016/j.ibmb.2024.104097

Products & Services: Proteins, Expression, Isolation and Analysis

The catalytic action of human d-lactate dehydrogenase is severely inhibited by oxalate and is impaired by mutations triggering d-lactate acidosis

Authors: Alessandra Stefan, Alberto Mucchi, Alejandro Hochkoeppler

Journal: Arch Biochem Biophys

PubMed ID: 38373542

Doi: 10.1016/j.abb.2024.109932

Products & Services: Mutagenesis Services

Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer

Authors: Kazuto Suda, Atsushi Okabe, Junichi Matsuo, Linda Shyue Huey Chuang, Ying Li, Nawaphat Jangphattananont, Naing Naing Mon, Khine Nyein Myint, Akihiro Yamamura, Jimmy Bok-Yan So, Dominic Chih-Cheng Voon, Henry Yang, Khay Guan Yeoh, Atsushi Kaneda, Yoshiaki Ito

Journal: Cancer Res Commun

PubMed ID: 38240752

Doi: 10.1158/2767-9764.CRC-22-0165

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Development and characterization of DIA 123, a fully human intact anti-CEACAM1 monoclonal antibody

Authors: Michela Centonze, Valentina Fiori, Maciej Kujawski, Lin Li, Patty Wong, Lindsay Williams, Tomas Di Mambro, Sabrina Dominici, Angelo Sparti, John E Shively, Mauro Magnani

Journal: PLoS ONE

PubMed ID: 38346003

Doi: 10.1371/journal.pone.0295345

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Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)

Authors: Ahmed Mohamed Hassan, Arwa Ahmed Zehairy, Al-Judaibi Awatif Abid, Sayed Sartaj Sohrab, Ibraheem Azhar Esam

Journal: Bioinformation

PubMed ID: 38497067

Doi: 10.6026/973206300200091

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Graphene Quantum Dots (GQD)-Mediated dsRNA Delivery for the Control of Fusarium Head Blight Disease in Wheat

Authors: Binod Gyawali, Rahim Rahimi, Houshang Alizadeh, Mohsen Mohammadi

Journal: ACS Appl Bio Mater

PubMed ID: 38422985

Doi: 10.1021/acsabm.3c00972

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Ebselen and TPI-1, as RecG helicase inhibitors, potently enhance the susceptibility of Pseudomonas aeruginosa to DNA damage agents

Authors: Longheng Li, Binbin Guo, Lin Dai, Chun Liu, Zhonghui Lin

Journal: Biochem Pharmacol

PubMed ID: 38354956

Doi: 10.1016/j.bcp.2024.116051

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miR-30e-5p regulates leukemia stem cell self-renewal through the Cyb561/ROS signaling pathway

Authors: Yanwen Ge, Mei Hong, Yu Zhang, Jiachen Wang, Lei Li, Hongkai Zhu, Yue Sheng, Wen-Shu Wu, Zhonghui Zhang

Journal: Haematologica

PubMed ID: 37584287

Doi: 10.3324/haematol.2023.282837

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PDGFRβ-Antagonistic Affibody-Mediated Tumor-Targeted Tumor Necrosis Factor-Alpha for Enhanced Radiotherapy in Lung Cancer

Authors: Xiaohui Tang, Jie Chen, Zhenxiong Zhao, Jie Liu, Ranfei Yu, Kunlong Zhao, Fei Wang, Yang Li, Baoqing Tian, Dandan Yuan, Yuguo Liu, Qing Fan

Journal: Mol Pharm

PubMed ID: 38364870

Doi: 10.1021/acs.molpharmaceut.3c00869

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of nucleotide MALDI-TOF-MS for the identification of species

Authors: Yelei Zhu, Zhengwei Liu, Lina Peng, Bin Liu, Kunyang Wu, Mingwu Zhang, Xiaomeng Wang, Junhang Pan

Journal: Front Cell Infect Microbiol

PubMed ID: 38379773

Doi: 10.3389/fcimb.2024.1335104

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Development, validation and application of an ion-pair reversed-phase liquid chromatography-tandem mass spectrometry method for the quantification of nusinersen

Authors: Xiao Zhang, Chunjie Sha, Wei Zhang, Fengjuan Zhao, Mingli Zhu, Guangyi Leng, Wanhui Liu

Journal: Bioanalysis

PubMed ID: 38334103

Doi: 10.4155/bio-2023-0218

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African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway

Authors: Guangqiang Ye, Zhaoxia Zhang, Xiaohong Liu, Hongyang Liu, Weiye Chen, Chunying Feng, Jiangnan Li, Qiongqiong Zhou, Dongming Zhao, Shuai Zhang, Hefeng Chen, Zhigao Bu, Li Huang, Changjiang Weng

Journal: J Virol

PubMed ID: 38353534

Doi: 10.1128/jvi.01834-23

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Multitrait engineering of Hassawi red rice for sustainable cultivation

Authors: Khalid Sedeek, Nahed Mohammed, Yong Zhou, Andrea Zuccolo, Krishnaveni Sanikommu, Sunitha Kantharajappa, Noor Al-Bader, Manal Tashkandi, Rod A Wing, Magdy M Mahfouz

Journal: Plant Sci

PubMed ID: 38325660

Doi: 10.1016/j.plantsci.2024.112018

Improvement of Carotenoids' Production by Increasing the Activity of Beta-Carotene Ketolase with Different Strategies

Authors: Qiaomian Zhou, Danqiong Huang, Haihong Yang, Zeyu Hong, Chaogang Wang

Journal: Microorganisms

PubMed ID: 38399781

Doi: 10.3390/microorganisms12020377

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Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies

Authors: Jing Lu, Shudan Tan, Hao Gu, Kunpeng Liu, Wei Huang, Zhaoli Yu, Guoliang Lu, Zihan Wu, Xiaobo Gao, Jinghua Zhao, Zongting Yao, Feng Yi, Yantao Yang, Hu Wang, Xue Hu, Mingqing Lu, Wei Li, Hui Zhou, Hang Yu, Chao Shan, Jinzhong Lin

Journal: Emerg Microbes Infect

PubMed ID: 38377136

Doi: 10.1080/22221751.2024.2321994

Products & Services: Proteins, Expression, Isolation and Analysis

Supramolecular self-assembly strategies of natural-based β-lactoglobulin modulating bitter perception of goat milk-derived bioactive peptides

Authors: Rong Zhang, Wei Jia

Journal: J Dairy Sci

PubMed ID: 38310962

Doi: 10.3168/jds.2023-24386

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Atypical Plant miRNA cal-miR2911: Robust Stability against Food Digestion and Specific Promoting Effect on in Mice

Authors: Qin Xu, Jianing Wang, Yi Zhang, Ying Li, Xinshu Qin, Yirao Xin, Yinglei Li, Ke Xu, Xingbin Yang, Xingyu Wang

Journal: J Agric Food Chem

PubMed ID: 38393993

Doi: 10.1021/acs.jafc.3c09511

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Using for High-Yield Production of Challenging Expression Targets and for Protein Perdeuteration

Authors: Natalia Mojica, Flore Kersten, Mateu Montserrat-Canals, G Robb Huhn Iii, Abelone M Tislevoll, Gabriele Cordara, Ken Teter, Ute Krengel

Journal: Biochemistry

PubMed ID: 38359344

Doi: 10.1021/acs.biochem.3c00612

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CRISPR Ribonucleoprotein-Mediated Precise Editing of Multiple Genes in Porcine Fibroblasts

Authors: Xiaochen Guo, Chang Liu, Yunjing Zhao, Chaoqian Jiang, Junxue Jin, Zhonghua Liu, Yanshuang Mu

Journal: Animals (Basel)

PubMed ID: 38396618

Doi: 10.3390/ani14040650

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Vaccine Based on Recombinant Fusion Protein Combining Hepatitis B Virus PreS with SARS-CoV-2 Wild-Type- and Omicron-Derived Receptor Binding Domain Strongly Induces Omicron-Neutralizing Antibodies in a Murine Model

Authors: Pia Gattinger, Bernhard Kratzer, Al Nasar Ahmed Sehgal, Anna Ohradanova-Repic, Laura Gebetsberger, Gabor Tajti, Margarete Focke-Tejkl, Mirjam Schaar, Verena Fuhrmann, Lukas Petrowitsch, Walter Keller, Sandra Högler, Hannes Stockinger, Winfried F Pickl, Rudolf Valenta

Journal: Vaccines (Basel)

PubMed ID: 38543863

Doi: 10.3390/vaccines12030229

Products & Services: Recombinant Proteins

NK-92MI Cells Engineered with Anti-claudin-6 Chimeric Antigen Receptors in Immunotherapy for Ovarian Cancer

Authors: Junping Li, Hong Hu, Hui Lian, Shuo Yang, Manting Liu, Jinping He, Bihui Cao, Dongni Chen, Yuling Hu, Chen Zhi, Yan Shen, Xiaodie Ye, Bingjia He, Ming Zhao, Weijun Fan, Linfeng Xu, Rom Leidner, Qingde Wu, Lili Yang, Zhenfeng Zhang

Journal: Int J Biol Sci

PubMed ID: 38481806

Doi: 10.7150/ijbs.88539

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NEAT1 repression by MED12 creates chemosensitivity in p53 wild-type breast cancer cells

Authors: Shengjie Zhang, Eui-Jun Kim, Junfeng Huang, Peng Liu, Kristine Donahue, Qinchuan Wang, Yidan Wang, Sean Mcilwain, Ling Xie, Xian Chen, Lingjun Li, Wei Xu

Journal: FEBS J

PubMed ID: 38380720

Doi: 10.1111/febs.17097

Products & Services: Proteins, Expression, Isolation and Analysis

Creation of a point-of-care therapeutics sensor using protein engineering, electrochemical sensing and electronic integration

Authors: Rong Cai, Chiagoziem Ngwadom, Ravindra Saxena, Jayashree Soman, Chase Bruggeman, David P Hickey, Rafael Verduzco, Caroline M Ajo-Franklin

Journal: Nat Commun

PubMed ID: 38402222

Doi: 10.1038/s41467-024-45789-9

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Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition

Authors: Sedona Eve Murphy, Alistair Nicol Boettiger

Journal: Nat Genet

PubMed ID: 38361032

Doi: 10.1038/s41588-024-01661-6

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Performance of Three Anti-SARS-CoV-2 Anti-S and One Anti-N Immunoassays for the Monitoring of Immune Status and Vaccine Response

Authors: Y Victoria Zhang, Attila Kumanovics, Joesph Wiencek, Stacy E F Melanson, Tanzy Love, Alan H B Wu, Zhen Zhao, Qing H Meng, David D Koch, Fred S Apple, Caitlin R Ondracek, Robert H Christenson

Journal: Viruses

PubMed ID: 38400067

Doi: 10.3390/v16020292

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Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer

Authors: Yingmin Jin, Aimin Jiang, Liying Sun, Yue Lu

Journal: BMC Cancer

PubMed ID: 38383342

Doi: 10.1186/s12885-024-11964-w

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CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells

Authors: Hongjie Wang, Theo Koob, Jonathan R Fromm, Ajay Gopal, Darrick Carter, André Lieber

Journal: Cancer Biol Ther

PubMed ID: 38361357

Doi: 10.1080/15384047.2024.2314322

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Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase

Authors: Joshua J Maw, Jesse A Coker, Tarun Arya, Christopher M Goins, Dhiraj Sonawane, Sang Hoon Han, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Nancy S Wang, Hannelore V Heemers, Jonathan D Macdonald, Shaun R Stauffer

Journal: J Med Chem

PubMed ID: 38330278

Doi: 10.1021/acs.jmedchem.3c01807

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mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms

Authors: Yusuf Ali, Celso E Gomez-Sanchez, Maria Plonczynski, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Elise P Gomez-Sanchez

Journal: Endocrinology

PubMed ID: 38325289

Doi: 10.1210/endocr/bqae015

Products & Services: Proteins, Expression, Isolation and Analysis

Exploring the immunogenicity of Rv2201-519: A T-cell epitope-based antigen derived from Mycobacterium tuberculosis AsnB with implications for tuberculosis infection detection and vaccine development

Authors: Xiuli Luan, Xueting Fan, Guilian Li, Mchao Li, Na Li, Yuhan Yan, Xiuqin Zhao, Haican Liu, Kanglin Wan

Journal: Int Immunopharmacol

PubMed ID: 38342063

Doi: 10.1016/j.intimp.2024.111542

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Discovery of Two Novel Immunoepitopes and Development of Peptide-based Sarcoidosis Immunoassay

Authors: Changya Peng , Jaya Talreja , Brennen Steinbauer , Kazuhiko Shinki , Laura L Koth , Lobelia Samavati

Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PubMed ID: 38385694

Doi: 10.1164/rccm.202306-1054OC

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Bicistronic expression of nuclear transgenes in Chlamydomonas reinhardtii

Authors: Nick Jacobebbinghaus, Kyle J Lauersen, Olaf Kruse, Thomas Baier

Journal: the plant journal

PubMed ID: 38415961

Doi: 10.1111/tpj.16677

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SPR spectroscopic analysis of myosin binding to wild type and mutant UNC45B

Authors: Silvana Valdebenito, Eliseo Eugenin, Andres Oberhauser

Journal: MicroPubl Biol

PubMed ID: 38404916

Doi: 10.17912/micropub.biology.001131

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Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

Authors: Daniel J Barrero, Sithara S Wijeratne, Xiaowei Zhao, Grace F Cunningham, Yan Rui, Christian R Nelson, Arimura Yasuhiro, Hironori Funabiki, Charles L Asbury, Zhiheng Yu, Radhika Subramanian, Sue Biggins

Journal: biorxiv

PubMed ID: 38464254

Doi: 10.1101/2024.02.28.582571

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NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route

Authors: Obed Boadi Amissah, Wenfang Chen, Jean de Dieu Habimana, Yirong Sun, Lihui Lin, Yujie Liu, Ling Wang, Zhaoming Liu, Omar Mukama, Rajesh Basnet, Hohua Liu, Junyi Li, Xuanyan Ding, Lingshuang Lv, Min Chen, Yalin Liang, Rongqi Huang, Zhiyuan Li

Journal: Cancer Cell Int

PubMed ID: 38336680

Doi: 10.1186/s12935-024-03249-w

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CD39 tumor infiltrating T cells from colorectal cancers exhibit dysfunctional phenotype

Authors: Yuan Feng, Xin Xu, Jiaxin Zhang, Christopher Sanderson, Jun Xia, Zhang Bu, Yili Yang, Peng Yang, Zhiliang Lu

Journal: Am J Cancer Res

PubMed ID: 38455401

Doi: 10.62347/IZEN3736

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A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

Authors: Felipe Guapo, Nicholas Donohue, Lisa Strasser, Stefano Boi, Florian Füssl, Alana Rainbow-Fletcher, Paul Getty, Ian Anderson, Niall Barron, Jonathan Bones

Journal: Int J Mol Sci

PubMed ID: 38474031

Doi: 10.3390/ijms25052785

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Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection

Authors: Diana Lourdes Padilla-Bórquez, Mónica Guadalupe Matuz-Flores, Jorge Hernández-Bello, Gabriela Athziri Sánchez-Zuno, Samuel García-Arellano, Edith Oregon-Romero, Melva Guadalupe Herrera-Godina, Guillermo González-Estevez, Norma Patricia Adan-Bante, Jesús Alfredo Rosas-Rodríguez, José Francisco Muñoz-Valle

Journal: Can J Infect Dis Med Microbiol

PubMed ID: 38384428

Doi: 10.1155/2024/8871439

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Distinct structural variants and repeat landscape shape the genomes of the ancient grapes Aglianico and Falanghina

Authors: Riccardo Aversano, Marina Iovene , Salvatore Esposito , Alberto L'Abbate , Clizia Villano , Ermanno Di Serio , Maria Francesca Cardone , Carlo Bergamini , Riccardo Aiese Cigliano , Vincenzo D'Amelia , Luigi Frusciante , Domenico Carputo

Journal: BMC Plant Biol.

PubMed ID: 38317087

Doi: 10.1186/s12870-024-04778-2

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Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1

Authors: Xiangwei Wu, Yunxiang Du, Lu-Jun Liang, Ruichao Ding, Tianyi Zhang, Hongyi Cai, Xiaolin Tian, Man Pan, Lei Liu

Journal: Nat Commun .

PubMed ID: 38341401

Doi: 10.1038/s41467-024-45635-y

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Mage Transposon: A Novel Gene Delivery System for Mammalian Cells

Authors: Jinghan Tian, Doudou Tong, Zhendong Li, Erqiang Wang, Yifei Yu, Hangya Lv, Zhendan Hu, Fang Sun, Guoping Wang, Min He, Tian Xia

Journal: Nucleic Acids Res .

PubMed ID: 38300794

Doi: 10.1093/nar/gkae048

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An oncolytic virus–T cell chimera for cancer immunotherapy

Authors: Yuxuan Chen , Xiaohong Chen , Weier Bao , Gang Liu , Wei Wei , Yuan Ping

Journal: Nat Biotechnol .

PubMed ID: 38336902

Doi: 10.1038/s41587-023-02118-7

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A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

Authors: Lorena M Coria , Juan Manuel Rodriguez , Agostina Demaria , Laura A Bruno , Mayra Rios Medrano , Celeste Pueblas Castro , Eliana F Castro , Sabrina A Del Priore , Andres C Hernando Insua , Ingrid G Kaufmann , Lucas M Saposnik , William B Stone , Lineia Prado , Ulises S Notaro , Ayelen N Amweg , Pablo U Diaz , Martin Avaro , Hugo Ortega , Ana Ceballos , Valeria Krum , Francisco M Zurvarra , Johanna E Sidabra , Ignacio Drehe , Jonathan A Baqué , Mariana Li Causi , Analia V De Nichilo , Cristian J Payes , Teresa Southard , Julio C Vega , Albert J Auguste , Diego E Álvarez , Juan M Flo , Karina A Pasquevich , Juliana Cassataro

Journal: Nat Commun

PubMed ID: 38307851

Doi: 10.1038/s41467-024-45180-8

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The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors

Authors: Luisa Statello , José Miguel Fernandez-Justel , Jovanna González , Marta Montes , Alessia Ranieri , Enrique Goñi , Aina M Mas , Maite Huarte

Journal: Nat Commun

PubMed ID: 38302450

Doi: 10.1038/s41467-024-45183-5

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Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1

Authors: Leon Tejwani, Neal G Ravindra, Changwoo Lee, Yubao Cheng, Billy Nguyen, Kimberly Luttik, Luhan Ni, Shupei Zhang, Logan M Morrison, John Gionco, Yangfei Xiang, Jennifer Yoon, Hannah Ro, Fatema Haidery, Rosalie M Grijalva, Eunwoo Bae, Kristen Kim , Regina T Martuscello, Harry T Orr, Huda Y Zoghbi , Hayley S McLoughlin, Laura P W Ranum, Vikram G Shakkottai, Phyllis L Faust, Siyuan Wang, David van Dijk, Janghoo Lim

Journal: Neuron

PubMed ID: 38016472

Doi: 10.1016/j.neuron.2023.10.039

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Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis

Authors: Zhentao Zi 1 2, Yi Rao

Journal: Sci Adv

PubMed ID: 38306436

Doi: 10.1126/sciadv.adj0146

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Essential functions of Inositol hexakisphosphate (IP6) in Murine Leukemia Virus replication

Authors: Banhi Biswas, Kin Kui Lai, Harrison Bracey, Siddhartha A K Datta, Demetria Harvin, Gregory A Sowd, Christopher Aiken, Alan Rein

Journal: biorxiv

PubMed ID: 38464197

Doi: 10.1101/2024.02.27.581940

Products & Services: Proteins, Expression, Isolation and Analysis

Examination of SARS-CoV-2 serological test results from multiple commercial and laboratory platforms with an in-house serum panel

Authors: Sandra N Lester, Megan Stumpf, Brandi D Freeman, Lisa Mills, Jarad Schiffer, Vera Semenova, Tao Jia, Rita Desai, Peter Browning, Bailey Alston, Muyiwa Ategbole, Shanna Bolcen, Alexander Chen, Ebenezer David, Panagiotis Manitis, Heather Tatum, Yunlong Qin, Briana Zellner, Jan Drobeniuc, Alexandra Tejada-Strop, Payel Chatterjee, Punya Shrivastava-Ranjan, M Harley Jenks, Laura K McMullan, Mike Flint, Christina F Spiropoulou, Glenn P Niemeyer, Bonnie J Werner, Christopher J Bean, Jeffrey A Johnson, Alex R Hoffmaster, Panayampalli S Satheshkumar, Amy J Schuh, S Michele Owen, Natalie J Thornburg

Journal: Access Microbiol

PubMed ID: 38482357

Doi: 10.1099/acmi.0.000463.v4

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient production of 2'-fucosyllactose from fructose through metabolically engineered recombinant Escherichia coli

Authors: Ran You, Lei Wang, Meirong Hu, Yong Tao

Journal: Microb Cell Fact

PubMed ID: 38303005

Doi: 10.1186/s12934-024-02312-5

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Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside

Authors: Julia Heinzelbecker, Marte Fauskanger, Ida Jonson, Ute Krengel, Geir Åge Løset, Ludvig Munthe, Anders Tveita

Journal: Front Immunol

PubMed ID: 38370401

Doi: 10.3389/fimmu.2024.1331345

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The expression of genes encoding novel Sesame oleosin variants facilitates enhanced triacylglycerol accumulation in Arabidopsis leaves and seeds

Authors: Sanket Anaokar, Yuanxue Liang, Xiao-Hong Yu, Yingqi Cai, Yuanheng Cai, John Shanklin

Journal: New Phytol

PubMed ID: 38329350

Doi: 10.1111/nph.19548

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A Cancer Nanovaccine for Co-Delivery of Peptide Neoantigens and Optimized Combinations of STING and TLR4 Agonists

Authors: Jessalyn J. Baljon, Alexander J. Kwiatkowski, Hayden M. Pagendarm, Payton T. Stone, Amrendra Kumar, Vijaya Bharti, Jacob A. Schulman, Kyle W. Becker, Eric W. Roth, Plamen P. Christov, Sebastian Joyce, and John T. Wilson*

Journal: ACS Nano

PubMed ID: 38386282

Doi: 10.1021/acsnano.3c04471

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Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA. 2.86 and FLip variants

Authors: Panke Qu 1, Kai Xu 1, Julia N Faraone 2, Negin Goodarzi 1, Yi-Min Zheng 1, Claire Carlin 3, Joseph S Bednash 4, Jeffrey C Horowitz 4, Rama K Mallampalli 4, Linda J Saif 5, Eugene M Oltz 6, Daniel Jones 7, Richard J Gumina 8, Shan-Lu Liu

Journal: Cell

PubMed ID: 38194968

Doi: 10.1016/j.cell.2023.12.026

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An Antioxidative and Active Shrinkage Hydrogel Integratedly Promotes Re-Epithelization and Skin Constriction for Enhancing Wound Closure

Authors: Jiacheng Sun, Wang Jia, Hedong Qi, Jiawei Huo, Xiaodan Liao, Yuan Xu, Jun Wang, Zihao Sun, Yang Liu, Jingchao Liu, Mingming Zhen, Chunru Wang, Chunli Bai

Journal: Adv Mater

PubMed ID: 38332741

Doi: 10.1002/adma.202312440

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Imaging of extracellular and intracellular ATP in pancreatic beta cells reveals correlation between glucose metabolism and purinergic signalling

Authors: Seyed M Ghiasi, Nynne M Christensen, Per A Pedersen, Emil Z Skovhøj, Ivana Novak

Journal: Cell Signal

PubMed ID: 38373668

Doi: 10.1016/j.cellsig.2024.111109

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Unveiling PET Hydrolase Surface Dynamics through Fluorescence Microscopy

Authors: A P Rennison, A Nousi, P Westh, R Marie, M S Møller

Journal: Chembiochem

PubMed ID: 38224131

Doi: 10.1002/cbic.202300661

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Exploring the ATG9A interactome uncovers interaction with VPS13A

Authors: Alexander R van Vliet, Harold B J Jefferies, Peter A Faull, Jessica Chadwick, Fairouz Ibrahim, Mark J Skehel, Sharon A Tooze

Journal: J Cell Sci

PubMed ID: 38294121

Doi: 10.1242/jcs.261081

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Phospho-eIF4E stimulation regulates coronavirus entry by selective expression of cell membrane-residential factors

Authors: Xiu-Zhong Zhang, Jing Wang, Wen-Jun Tian, Jing-Ling You, Xiao-Jing Chi, Xiao-Jia Wang

Journal: J Virol

PubMed ID: 38299843

Doi: 10.1128/jvi.01948-23

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KNL1 and NDC80 represent new universal markers for the detection of functional centromeres in plants

Authors: Ludmila Oliveira, Pavel Neumann, Yennifer Mata-Sucre, Yi-Tzu Kuo, André Marques, Veit Schubert, Jiří Macas

Journal: Chromosome Res

PubMed ID: 38403686

Doi: 10.1007/s10577-024-09747-x

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Precise fine-turning of GhTFL1 by base editing tools defines ideal cotton plant architecture

Authors: Guanying Wang, Fuqiu Wang, Zhongping Xu, Ying Wang, Can Zhang, Yi Zhou, Fengjiao Hui, Xiyan Yang, Xinhui Nie, Xianlong Zhang, Shuangxia Jin

Journal: Genome Biol

PubMed ID: 38409014

Doi: 10.1186/s13059-024-03189-8

Plum blossom low molecular weight polypeptide protects HaCaT cells against UVB-induced oxidative damage in vitro and underlying mechanism

Authors: Zhixiong Chen, Ping Cao, Tingheng Zhu, Cui Yan, Zhongbo Zheng, Hong Yao

Journal: Skin Res Technol

PubMed ID: 38282275

Doi: 10.1111/srt.13582

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Supplementation of citrus pectin with whole-cell pectinase PG5 on Pichia pastoris promotes recovery of colitis and enhances intestinal barrier function in DSS-treated mice

Authors: Li Zhang, Jing Ren, Tianfei Yu, Yuanrong Li, Yanshun Li, Shuang Lu, Xiaohua Guo

Journal: Int J Biol Macromol

PubMed ID: 38428761

Doi: 10.1016/j.ijbiomac.2024.130476

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Recombinant Rod Domain of Vimentin Reduces SARS-CoV-2 Viral Replication by Blocking Spike Protein-ACE2 Interactions

Authors: Fong Wilson Lam, Cameron August Brown, Shannon Elizabeth Ronca

Journal: Int J Mol Sci

PubMed ID: 38473724

Doi: 10.3390/ijms25052477

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Harnessing Biomaterials to Amplify Immunity in Aged Mice through T Memory Stem Cells

Authors: Mohammad Mahdi Hasani-Sadrabadi, Fatemeh S Majedi, Jana Zarubova, Timothy J Thauland, Vaithilingaraja Arumugaswami, Tzung K Hsiai, Louis-S Bouchard, Manish J Butte, Song Li

Journal: ACS Nano

PubMed ID: 38381620

Doi: 10.1021/acsnano.3c08559

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A novel vaccine strategy using quick and easy conversion of bacterial pathogens to unnatural amino acid-auxotrophic suicide derivatives

Authors: Yuya Nagasawa, Momoko Nakayama, Yusuke Kato, Yohsuke Ogawa, Swarmistha Devi Aribam, Yusaku Tsugami, Taketoshi Iwata, Osamu Mikami, Aoi Sugiyama, Megumi Onishi, Tomohito Hayashi, Masahiro Eguchi

Journal: Microbiol Spectr

PubMed ID: 38385737

Doi: 10.1128/spectrum.03557-23

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Structure of the recombinant RNA polymerase from African Swine Fever Virus

Authors: Simona Pilotto, Michal Sýkora, Gwenny Cackett, Christopher Dulson, Finn Werner

Journal: Nat Commun

PubMed ID: 38383525

Doi: 10.1038/s41467-024-45842-7

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Impact of Antenatal SARS-CoV-2 Exposure on SARS-CoV-2 Neutralization Potency

Authors: Chia-Jung Chiang, Wei-Lun Hsu, Mei-Tsz Su, Wen-Chien Ko, Keng-Fu Hsu, Pei-Yin Tsai

Journal: Vaccines (Basel)

PubMed ID: 38400147

Doi: 10.3390/vaccines12020164

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Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism

Authors: Yilin Ren, Xinyi Shi, Jing Mu, Shenyin Liu, Xin Qian, Wenlong Pei, Shanhong Ni, Zhengduo Zhang, Lei Li, Zhan Zhang

Journal: Food Funct

PubMed ID: 38236135

Doi: 10.1039/d3fo04347a

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Contribution of to Docosahexaenoic Acid (DHA) Synthesis at the Transcriptional Regulation Level in Common Carp,

Authors: Hanyuan Zhang, Peizhen Li, Youxiu Zhu, Yanliang Jiang, Jianxin Feng, Zixia Zhao, Jian Xu

Journal: Animals (Basel)

PubMed ID: 38396511

Doi: 10.3390/ani14040544

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Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons

Authors: Wenchao Gu, Sijin Luozhong, Simian Cai, Ketaki Londhe, Nadine Elkasri, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Yujie Yin, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Qiuming Yu, Melissa Warden, Robert Langer, Shaoyi Jiang

Journal: Nat Biomed Eng

PubMed ID: 38374224

Doi: 10.1038/s41551-023-01150-x

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Characterization of core oligosaccharide synthesis reveals novel aspects of lipooligosaccharide assembly

Authors: Leah M VanOtterloo, Luis A Macias, Matthew J Powers, Jennifer S Brodbelt, M Stephen Trent

Journal: MBio

PubMed ID: 38349180

Doi: 10.1128/mbio.03013-23

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Comparative analysis of tuberculin and defined antigen skin tests for detection of bovine tuberculosis in buffaloes (Bubalus bubalis) in Haryana state, India

Authors: Mohit Kumar, Tarun Kumar, Babu Lal Jangir, Mahavir Singh, Devan Arora, Yogesh Bangar, Andrew Conlan, Martin Vordermeier, Douwe Bakker, S M Byregowda, Sreenidhi Srinivasan, Vivek Kapur, Naresh Jindal

Journal: BMC Vet Res

PubMed ID: 38395846

Doi: 10.1186/s12917-024-03913-3

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Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice

Authors: Arezo Kaveh-Samani, Samaneh Dalali, Fatemeh Kaviani, Tohid Piri-Gharaghie, Abbas Doosti

Journal: BMC Immunol

PubMed ID: 38310250

Doi: 10.1186/s12865-024-00602-6

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Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation

Authors: Yue Liu, Zhihui Zhang, Hongmiao Hu, Wei Chen, Fan Zhang, Qian Wang, Changshi Wang, Kaige Yan, Jiamu Du

Journal: Nat Plants

PubMed ID: 38413824

Doi: 10.1038/s41477-024-01640-z

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Improving the Efficiency of CRISPR Ribonucleoprotein-Mediated Precise Gene Editing by Small Molecules in Porcine Fibroblasts

Authors: Yunjing Zhao, Xinyu Li, Chang Liu, Chaoqian Jiang, Xiaochen Guo, Qianqian Xu, Zhi Yin, Zhonghua Liu, Yanshuang Mu

Journal: Animals (Basel)

PubMed ID: 38473105

Doi: 10.3390/ani14050719

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Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor YtvA: From Photoactivation to Downstream Regulation

Authors: YongLe He, Jinnette Tolentino Collado, James N Iuliano, Helena A Woroniecka, Christopher R Hall, Agnieszka A Gil, Sergey P Laptenok, Gregory M Greetham, Boris Illarionov, Adelbert Bacher, Markus Fischer, Jarrod B French, Andras Lukacs, Stephen R Meech, Peter J Tonge

Journal: ACS Chemical Biology

PubMed ID: 38385342

Doi: 10.1021/acschembio.3c00722

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Long noncoding RNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote lung carcinogenesis

Authors: Po-Shun Wang, Zulong Liu, Osama Sweef, Jie Xie, Jing Chen, Haining Zhu, Patti C Zeidler-Erdely, Chengfeng Yang, Zhishan Wang

Journal: Environ Int

PubMed ID: 38364571

Doi: 10.1016/j.envint.2024.108494

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ANGPTL4 regulates ovarian cancer progression by activating the ERK1/2 pathway

Authors: Jiaqi Xu, Fei Wu, Yue Zhu, Tiantian Wu, Tianyue Cao, Wenxin Gao, Meng Liu, Weifeng Qian, Guannan Feng, Xiaoxue Xi, Shunyu Hou

Journal: Cancer Cell Int

PubMed ID: 38311733

Doi: 10.1186/s12935-024-03246-z

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The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation

Authors: Youli Zhou, Rui Lv, Richard D Ye, Ruobing Ren, Leiye Yu

Journal: Biochem Biophys Res Commun

PubMed ID: 38422897

Doi: 10.1016/j.bbrc.2024.149588

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Efficient Expression and Characterization of an Endo-Type Lyase HCLase_M28 and Its Gradual Scale-Up Fermentation for the Preparation of Chondroitin Sulfate Oligosaccharides

Authors: Ruibao Ju, Baoqin Han, Feng Han, Yanfei Peng

Journal: Appl Biochem Biotechnol

PubMed ID: 38386140

Doi: 10.1007/s12010-024-04878-7

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Design and development of multiepitope chimeric antigens by bioinformatic and bacterial based recombinant expression methods, with potential application for bovine tuberculosis serodiagnosis

Authors: Cassiano Martin Batista, Josir Laine Veschi, Vanessa Felipe de Souza, Leonardo Foti, Lea Chapaval Andri

Journal: Vet Immunol Immunopathol

PubMed ID: 38377627

Doi: 10.1016/j.vetimm.2024.110729

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Functional analyses of TRAF6 gene in Argopecten scallops

Authors: Xiaotong Zhang, Xia Wang, Jieyu Chen, Min Chen, Xia Lu, Junhao Ning, Haijun Liu, Guilong Liu, Xin Xu, Xiaoxu Qu, Kai Yu, He Xu, Chunde Wang, Bo Liu

Journal: Fish Shellfish Immunol

PubMed ID: 38354964

Doi: 10.1016/j.fsi.2024.109443

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Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome

Authors: Fraser G Ferens, Cassandra C Taber, Sarah Stuart, Mia Hubert, Daniel Tarade, Jeffrey E Lee, Michael Ohh

Journal: Commun Biol

PubMed ID: 38418569

Doi: 10.1038/s42003-024-05904-4

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Comparison of Cas12a and Cas9-mediated mutagenesis in tomato cells

Authors: Ellen Slaman, Lisanne Kottenhagen, William de Martines, Gerco C Angenent, Ruud A de Maagd

Journal: Sci Rep

PubMed ID: 38402312

Doi: 10.1038/s41598-024-55088-4

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Crossprotection induced by virus-like particles containing influenza dual-hemagglutinin and M2 ectodomain

Authors: Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Min-Ju Kim, Ki-Back Chu, Hae-Ji Kang, Fu-Shi Quan

Journal: Nanomedicine (Lond)

PubMed ID: 38390688

Doi: 10.2217/nnm-2023-0353

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