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Essential functions of Inositol hexakisphosphate (IP6) in Murine Leukemia Virus replication

Authors: Banhi Biswas, Kin Kui Lai, Harrison Bracey, Siddhartha A K Datta, Demetria Harvin, Gregory A Sowd, Christopher Aiken, Alan Rein

Journal: biorxiv

PubMed ID: 38464197

Doi: 10.1101/2024.02.27.581940

Products & Services: Proteins, Expression, Isolation and Analysis

Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

Authors: Daniel J Barrero, Sithara S Wijeratne, Xiaowei Zhao, Grace F Cunningham, Yan Rui, Christian R Nelson, Arimura Yasuhiro, Hironori Funabiki, Charles L Asbury, Zhiheng Yu, Radhika Subramanian, Sue Biggins

Journal: biorxiv

PubMed ID: 38464254

Doi: 10.1101/2024.02.28.582571

Products & Services: Recombinant Proteins

Unveiling PET Hydrolase Surface Dynamics through Fluorescence Microscopy

Authors: A P Rennison, A Nousi, P Westh, R Marie, M S Møller

Journal: Chembiochem

PubMed ID: 38224131

Doi: 10.1002/cbic.202300661

Products & Services: Molecular Biology Reagents

NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route

Authors: Obed Boadi Amissah, Wenfang Chen, Jean de Dieu Habimana, Yirong Sun, Lihui Lin, Yujie Liu, Ling Wang, Zhaoming Liu, Omar Mukama, Rajesh Basnet, Hohua Liu, Junyi Li, Xuanyan Ding, Lingshuang Lv, Min Chen, Yalin Liang, Rongqi Huang, Zhiyuan Li

Journal: Cancer Cell Int

PubMed ID: 38336680

Doi: 10.1186/s12935-024-03249-w

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CD39 tumor infiltrating T cells from colorectal cancers exhibit dysfunctional phenotype

Authors: Yuan Feng, Xin Xu, Jiaxin Zhang, Christopher Sanderson, Jun Xia, Zhang Bu, Yili Yang, Peng Yang, Zhiliang Lu

Journal: Am J Cancer Res

PubMed ID: 38455401

Doi: 10.62347/IZEN3736

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Exploring the ATG9A interactome uncovers interaction with VPS13A

Authors: Alexander R van Vliet, Harold B J Jefferies, Peter A Faull, Jessica Chadwick, Fairouz Ibrahim, Mark J Skehel, Sharon A Tooze

Journal: J Cell Sci

PubMed ID: 38294121

Doi: 10.1242/jcs.261081

Products & Services: Proteins, Expression, Isolation and Analysis

A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

Authors: Felipe Guapo, Nicholas Donohue, Lisa Strasser, Stefano Boi, Florian Füssl, Alana Rainbow-Fletcher, Paul Getty, Ian Anderson, Niall Barron, Jonathan Bones

Journal: Int J Mol Sci

PubMed ID: 38474031

Doi: 10.3390/ijms25052785

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Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection

Authors: Diana Lourdes Padilla-Bórquez, Mónica Guadalupe Matuz-Flores, Jorge Hernández-Bello, Gabriela Athziri Sánchez-Zuno, Samuel García-Arellano, Edith Oregon-Romero, Melva Guadalupe Herrera-Godina, Guillermo González-Estevez, Norma Patricia Adan-Bante, Jesús Alfredo Rosas-Rodríguez, José Francisco Muñoz-Valle

Journal: Can J Infect Dis Med Microbiol

PubMed ID: 38384428

Doi: 10.1155/2024/8871439

Products & Services: Proteins, Expression, Isolation and Analysis

ANGPTL4 regulates ovarian cancer progression by activating the ERK1/2 pathway

Authors: Jiaqi Xu, Fei Wu, Yue Zhu, Tiantian Wu, Tianyue Cao, Wenxin Gao, Meng Liu, Weifeng Qian, Guannan Feng, Xiaoxue Xi, Shunyu Hou

Journal: Cancer Cell Int

PubMed ID: 38311733

Doi: 10.1186/s12935-024-03246-z

Products & Services: Proteins, Expression, Isolation and Analysis

The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation

Authors: Youli Zhou, Rui Lv, Richard D Ye, Ruobing Ren, Leiye Yu

Journal: Biochem Biophys Res Commun

PubMed ID: 38422897

Doi: 10.1016/j.bbrc.2024.149588

Products & Services: Proteins, Expression, Isolation and Analysis

Plum blossom low molecular weight polypeptide protects HaCaT cells against UVB-induced oxidative damage in vitro and underlying mechanism

Authors: Zhixiong Chen, Ping Cao, Tingheng Zhu, Cui Yan, Zhongbo Zheng, Hong Yao

Journal: Skin Res Technol

PubMed ID: 38282275

Doi: 10.1111/srt.13582

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Efficient Expression and Characterization of an Endo-Type Lyase HCLase_M28 and Its Gradual Scale-Up Fermentation for the Preparation of Chondroitin Sulfate Oligosaccharides

Authors: Ruibao Ju, Baoqin Han, Feng Han, Yanfei Peng

Journal: Appl Biochem Biotechnol

PubMed ID: 38386140

Doi: 10.1007/s12010-024-04878-7

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Recombinant Rod Domain of Vimentin Reduces SARS-CoV-2 Viral Replication by Blocking Spike Protein-ACE2 Interactions

Authors: Fong Wilson Lam, Cameron August Brown, Shannon Elizabeth Ronca

Journal: Int J Mol Sci

PubMed ID: 38473724

Doi: 10.3390/ijms25052477

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Bicistronic expression of nuclear transgenes in Chlamydomonas reinhardtii

Authors: Nick Jacobebbinghaus, Kyle J Lauersen, Olaf Kruse, Thomas Baier

Journal: the plant journal

PubMed ID: 38415961

Doi: 10.1111/tpj.16677

Products & Services: Gene Synthesis

Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1

Authors: Leon Tejwani, Neal G Ravindra, Changwoo Lee, Yubao Cheng, Billy Nguyen, Kimberly Luttik, Luhan Ni, Shupei Zhang, Logan M Morrison, John Gionco, Yangfei Xiang, Jennifer Yoon, Hannah Ro, Fatema Haidery, Rosalie M Grijalva, Eunwoo Bae, Kristen Kim , Regina T Martuscello, Harry T Orr, Huda Y Zoghbi , Hayley S McLoughlin, Laura P W Ranum, Vikram G Shakkottai, Phyllis L Faust, Siyuan Wang, David van Dijk, Janghoo Lim

Journal: Neuron

PubMed ID: 38016472

Doi: 10.1016/j.neuron.2023.10.039

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Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis

Authors: Zhentao Zi 1 2, Yi Rao

Journal: Sci Adv

PubMed ID: 38306436

Doi: 10.1126/sciadv.adj0146

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Examination of SARS-CoV-2 serological test results from multiple commercial and laboratory platforms with an in-house serum panel

Authors: Sandra N Lester, Megan Stumpf, Brandi D Freeman, Lisa Mills, Jarad Schiffer, Vera Semenova, Tao Jia, Rita Desai, Peter Browning, Bailey Alston, Muyiwa Ategbole, Shanna Bolcen, Alexander Chen, Ebenezer David, Panagiotis Manitis, Heather Tatum, Yunlong Qin, Briana Zellner, Jan Drobeniuc, Alexandra Tejada-Strop, Payel Chatterjee, Punya Shrivastava-Ranjan, M Harley Jenks, Laura K McMullan, Mike Flint, Christina F Spiropoulou, Glenn P Niemeyer, Bonnie J Werner, Christopher J Bean, Jeffrey A Johnson, Alex R Hoffmaster, Panayampalli S Satheshkumar, Amy J Schuh, S Michele Owen, Natalie J Thornburg

Journal: Access Microbiol

PubMed ID: 38482357

Doi: 10.1099/acmi.0.000463.v4

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient production of 2'-fucosyllactose from fructose through metabolically engineered recombinant Escherichia coli

Authors: Ran You, Lei Wang, Meirong Hu, Yong Tao

Journal: Microb Cell Fact

PubMed ID: 38303005

Doi: 10.1186/s12934-024-02312-5

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The expression of genes encoding novel Sesame oleosin variants facilitates enhanced triacylglycerol accumulation in Arabidopsis leaves and seeds

Authors: Sanket Anaokar, Yuanxue Liang, Xiao-Hong Yu, Yingqi Cai, Yuanheng Cai, John Shanklin

Journal: New Phytol

PubMed ID: 38329350

Doi: 10.1111/nph.19548

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Phospho-eIF4E stimulation regulates coronavirus entry by selective expression of cell membrane-residential factors

Authors: Xiu-Zhong Zhang, Jing Wang, Wen-Jun Tian, Jing-Ling You, Xiao-Jing Chi, Xiao-Jia Wang

Journal: J Virol

PubMed ID: 38299843

Doi: 10.1128/jvi.01948-23

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Distinct structural variants and repeat landscape shape the genomes of the ancient grapes Aglianico and Falanghina

Authors: Riccardo Aversano, Marina Iovene , Salvatore Esposito , Alberto L'Abbate , Clizia Villano , Ermanno Di Serio , Maria Francesca Cardone , Carlo Bergamini , Riccardo Aiese Cigliano , Vincenzo D'Amelia , Luigi Frusciante , Domenico Carputo

Journal: BMC Plant Biol.

PubMed ID: 38317087

Doi: 10.1186/s12870-024-04778-2

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Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1

Authors: Xiangwei Wu, Yunxiang Du, Lu-Jun Liang, Ruichao Ding, Tianyi Zhang, Hongyi Cai, Xiaolin Tian, Man Pan, Lei Liu

Journal: Nat Commun .

PubMed ID: 38341401

Doi: 10.1038/s41467-024-45635-y

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Mage Transposon: A Novel Gene Delivery System for Mammalian Cells

Authors: Jinghan Tian, Doudou Tong, Zhendong Li, Erqiang Wang, Yifei Yu, Hangya Lv, Zhendan Hu, Fang Sun, Guoping Wang, Min He, Tian Xia

Journal: Nucleic Acids Res .

PubMed ID: 38300794

Doi: 10.1093/nar/gkae048

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An oncolytic virus–T cell chimera for cancer immunotherapy

Authors: Yuxuan Chen , Xiaohong Chen , Weier Bao , Gang Liu , Wei Wei , Yuan Ping

Journal: Nat Biotechnol .

PubMed ID: 38336902

Doi: 10.1038/s41587-023-02118-7

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A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

Authors: Lorena M Coria , Juan Manuel Rodriguez , Agostina Demaria , Laura A Bruno , Mayra Rios Medrano , Celeste Pueblas Castro , Eliana F Castro , Sabrina A Del Priore , Andres C Hernando Insua , Ingrid G Kaufmann , Lucas M Saposnik , William B Stone , Lineia Prado , Ulises S Notaro , Ayelen N Amweg , Pablo U Diaz , Martin Avaro , Hugo Ortega , Ana Ceballos , Valeria Krum , Francisco M Zurvarra , Johanna E Sidabra , Ignacio Drehe , Jonathan A Baqué , Mariana Li Causi , Analia V De Nichilo , Cristian J Payes , Teresa Southard , Julio C Vega , Albert J Auguste , Diego E Álvarez , Juan M Flo , Karina A Pasquevich , Juliana Cassataro

Journal: Nat Commun

PubMed ID: 38307851

Doi: 10.1038/s41467-024-45180-8

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The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors

Authors: Luisa Statello , José Miguel Fernandez-Justel , Jovanna González , Marta Montes , Alessia Ranieri , Enrique Goñi , Aina M Mas , Maite Huarte

Journal: Nat Commun

PubMed ID: 38302450

Doi: 10.1038/s41467-024-45183-5

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A Cancer Nanovaccine for Co-Delivery of Peptide Neoantigens and Optimized Combinations of STING and TLR4 Agonists

Authors: Jessalyn J. Baljon, Alexander J. Kwiatkowski, Hayden M. Pagendarm, Payton T. Stone, Amrendra Kumar, Vijaya Bharti, Jacob A. Schulman, Kyle W. Becker, Eric W. Roth, Plamen P. Christov, Sebastian Joyce, and John T. Wilson*

Journal: ACS Nano

PubMed ID: 38386282

Doi: 10.1021/acsnano.3c04471

Products & Services: Peptide Synthesis

Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA. 2.86 and FLip variants

Authors: Panke Qu 1, Kai Xu 1, Julia N Faraone 2, Negin Goodarzi 1, Yi-Min Zheng 1, Claire Carlin 3, Joseph S Bednash 4, Jeffrey C Horowitz 4, Rama K Mallampalli 4, Linda J Saif 5, Eugene M Oltz 6, Daniel Jones 7, Richard J Gumina 8, Shan-Lu Liu

Journal: Cell

PubMed ID: 38194968

Doi: 10.1016/j.cell.2023.12.026

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SPR spectroscopic analysis of myosin binding to wild type and mutant UNC45B

Authors: Silvana Valdebenito, Eliseo Eugenin, Andres Oberhauser

Journal: MicroPubl Biol

PubMed ID: 38404916

Doi: 10.17912/micropub.biology.001131

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Imaging of extracellular and intracellular ATP in pancreatic beta cells reveals correlation between glucose metabolism and purinergic signalling

Authors: Seyed M Ghiasi, Nynne M Christensen, Per A Pedersen, Emil Z Skovhøj, Ivana Novak

Journal: Cell Signal

PubMed ID: 38373668

Doi: 10.1016/j.cellsig.2024.111109

Products & Services: Proteins, Expression, Isolation and Analysis

Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside

Authors: Julia Heinzelbecker, Marte Fauskanger, Ida Jonson, Ute Krengel, Geir Åge Løset, Ludvig Munthe, Anders Tveita

Journal: Front Immunol

PubMed ID: 38370401

Doi: 10.3389/fimmu.2024.1331345

Products & Services: Gene Synthesis

Long noncoding RNA ABHD11-AS1 interacts with SART3 and regulates CD44 RNA alternative splicing to promote lung carcinogenesis

Authors: Po-Shun Wang, Zulong Liu, Osama Sweef, Jie Xie, Jing Chen, Haining Zhu, Patti C Zeidler-Erdely, Chengfeng Yang, Zhishan Wang

Journal: Environ Int

PubMed ID: 38364571

Doi: 10.1016/j.envint.2024.108494

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KNL1 and NDC80 represent new universal markers for the detection of functional centromeres in plants

Authors: Ludmila Oliveira, Pavel Neumann, Yennifer Mata-Sucre, Yi-Tzu Kuo, André Marques, Veit Schubert, Jiří Macas

Journal: Chromosome Res

PubMed ID: 38403686

Doi: 10.1007/s10577-024-09747-x

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Supplementation of citrus pectin with whole-cell pectinase PG5 on Pichia pastoris promotes recovery of colitis and enhances intestinal barrier function in DSS-treated mice

Authors: Li Zhang, Jing Ren, Tianfei Yu, Yuanrong Li, Yanshun Li, Shuang Lu, Xiaohua Guo

Journal: Int J Biol Macromol

PubMed ID: 38428761

Doi: 10.1016/j.ijbiomac.2024.130476

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Precise fine-turning of GhTFL1 by base editing tools defines ideal cotton plant architecture

Authors: Guanying Wang, Fuqiu Wang, Zhongping Xu, Ying Wang, Can Zhang, Yi Zhou, Fengjiao Hui, Xiyan Yang, Xinhui Nie, Xianlong Zhang, Shuangxia Jin

Journal: Genome Biol

PubMed ID: 38409014

Doi: 10.1186/s13059-024-03189-8

Design and development of multiepitope chimeric antigens by bioinformatic and bacterial based recombinant expression methods, with potential application for bovine tuberculosis serodiagnosis

Authors: Cassiano Martin Batista, Josir Laine Veschi, Vanessa Felipe de Souza, Leonardo Foti, Lea Chapaval Andri

Journal: Vet Immunol Immunopathol

PubMed ID: 38377627

Doi: 10.1016/j.vetimm.2024.110729

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Functional analyses of TRAF6 gene in Argopecten scallops

Authors: Xiaotong Zhang, Xia Wang, Jieyu Chen, Min Chen, Xia Lu, Junhao Ning, Haijun Liu, Guilong Liu, Xin Xu, Xiaoxu Qu, Kai Yu, He Xu, Chunde Wang, Bo Liu

Journal: Fish Shellfish Immunol

PubMed ID: 38354964

Doi: 10.1016/j.fsi.2024.109443

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Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome

Authors: Fraser G Ferens, Cassandra C Taber, Sarah Stuart, Mia Hubert, Daniel Tarade, Jeffrey E Lee, Michael Ohh

Journal: Commun Biol

PubMed ID: 38418569

Doi: 10.1038/s42003-024-05904-4

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Crossprotection induced by virus-like particles containing influenza dual-hemagglutinin and M2 ectodomain

Authors: Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Min-Ju Kim, Ki-Back Chu, Hae-Ji Kang, Fu-Shi Quan

Journal: Nanomedicine (Lond)

PubMed ID: 38390688

Doi: 10.2217/nnm-2023-0353

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Establishment of a Dual-Vector System for Gene Delivery Utilizing Prototype Foamy Virus

Authors: Soo-Yeon Cho, Yoon Jae Lee, Seong-Mook Jung, Young Min Son, Cha-Gyun Shin, Eui Tae Kim, Kyoung-Dong Kim

Journal: J Microbiol Biotechnol

PubMed ID: 38379304

Doi: 10.4014/jmb.2312.12026

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A diffusible small-RNA-based Turing system dynamically coordinates organ polarity

Authors: Emanuele Scacchi, Gael Paszkiewicz, Khoa Thi Nguyen, Shreyas Meda, Agata Burian, Walter de Back, Marja C P Timmermans

Journal: Nat Plants

PubMed ID: 38409292

Doi: 10.1038/s41477-024-01634-x

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Long-Term Dynamic Changes in Hybrid Immunity over Six Months after Inactivated and Adenoviral Vector Vaccination in Individuals with Previous SARS-CoV-2 Infection

Authors: Nungruthai Suntronwong, Sitthichai Kanokudom, Chompoonut Auphimai, Thanunrat Thongmee, Suvichada Assawakosri, Preeyaporn Vichaiwattana, Ritthideach Yorsaeng, Thaneeya Duangchinda, Warangkana Chantima, Pattarakul Pakchotanon, Pornjarim Nilyanimit, Donchida Srimuan, Thaksaporn Thatsanathorn, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Yong Poovorawan

Journal: Vaccines (Basel)

PubMed ID: 38400163

Doi: 10.3390/vaccines12020180

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Involvement of a catalase gene in lignin catalysis and immune defense against pathogenic fungus in Coptotermes formosanus: a potential new target for termite control

Authors: Wenhui Zeng, Danni Shen, Wenjing Wu, Shijun Zhang, Zhiqiang Li, Dandan Zhang

Journal: Pest Manag Sci

PubMed ID: 38358092

Doi: 10.1002/ps.8029

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Contribution of to Docosahexaenoic Acid (DHA) Synthesis at the Transcriptional Regulation Level in Common Carp,

Authors: Hanyuan Zhang, Peizhen Li, Youxiu Zhu, Yanliang Jiang, Jianxin Feng, Zixia Zhao, Jian Xu

Journal: Animals (Basel)

PubMed ID: 38396511

Doi: 10.3390/ani14040544

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Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice

Authors: Arezo Kaveh-Samani, Samaneh Dalali, Fatemeh Kaviani, Tohid Piri-Gharaghie, Abbas Doosti

Journal: BMC Immunol

PubMed ID: 38310250

Doi: 10.1186/s12865-024-00602-6

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Comparative analysis of tuberculin and defined antigen skin tests for detection of bovine tuberculosis in buffaloes (Bubalus bubalis) in Haryana state, India

Authors: Mohit Kumar, Tarun Kumar, Babu Lal Jangir, Mahavir Singh, Devan Arora, Yogesh Bangar, Andrew Conlan, Martin Vordermeier, Douwe Bakker, S M Byregowda, Sreenidhi Srinivasan, Vivek Kapur, Naresh Jindal

Journal: BMC Vet Res

PubMed ID: 38395846

Doi: 10.1186/s12917-024-03913-3

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Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation

Authors: Yue Liu, Zhihui Zhang, Hongmiao Hu, Wei Chen, Fan Zhang, Qian Wang, Changshi Wang, Kaige Yan, Jiamu Du

Journal: Nat Plants

PubMed ID: 38413824

Doi: 10.1038/s41477-024-01640-z

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Improving the Efficiency of CRISPR Ribonucleoprotein-Mediated Precise Gene Editing by Small Molecules in Porcine Fibroblasts

Authors: Yunjing Zhao, Xinyu Li, Chang Liu, Chaoqian Jiang, Xiaochen Guo, Qianqian Xu, Zhi Yin, Zhonghua Liu, Yanshuang Mu

Journal: Animals (Basel)

PubMed ID: 38473105

Doi: 10.3390/ani14050719

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Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor YtvA: From Photoactivation to Downstream Regulation

Authors: YongLe He, Jinnette Tolentino Collado, James N Iuliano, Helena A Woroniecka, Christopher R Hall, Agnieszka A Gil, Sergey P Laptenok, Gregory M Greetham, Boris Illarionov, Adelbert Bacher, Markus Fischer, Jarrod B French, Andras Lukacs, Stephen R Meech, Peter J Tonge

Journal: ACS Chemical Biology

PubMed ID: 38385342

Doi: 10.1021/acschembio.3c00722

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Heterotypic interactions can drive selective co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex

Authors: Richoo B Davis, Anushka Supakar, Aishwarya Kanchi Ranganath, Mahdi Muhammad Moosa, Priya R Banerjee

Journal: Nature Communications

PubMed ID: 38326345

Doi: 10.1038/s41467-024-44945-5

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Comparison of Cas12a and Cas9-mediated mutagenesis in tomato cells

Authors: Ellen Slaman, Lisanne Kottenhagen, William de Martines, Gerco C Angenent, Ruud A de Maagd

Journal: Sci Rep

PubMed ID: 38402312

Doi: 10.1038/s41598-024-55088-4

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Harnessing Biomaterials to Amplify Immunity in Aged Mice through T Memory Stem Cells

Authors: Mohammad Mahdi Hasani-Sadrabadi, Fatemeh S Majedi, Jana Zarubova, Timothy J Thauland, Vaithilingaraja Arumugaswami, Tzung K Hsiai, Louis-S Bouchard, Manish J Butte, Song Li

Journal: ACS Nano

PubMed ID: 38381620

Doi: 10.1021/acsnano.3c08559

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A novel vaccine strategy using quick and easy conversion of bacterial pathogens to unnatural amino acid-auxotrophic suicide derivatives

Authors: Yuya Nagasawa, Momoko Nakayama, Yusuke Kato, Yohsuke Ogawa, Swarmistha Devi Aribam, Yusaku Tsugami, Taketoshi Iwata, Osamu Mikami, Aoi Sugiyama, Megumi Onishi, Tomohito Hayashi, Masahiro Eguchi

Journal: Microbiol Spectr

PubMed ID: 38385737

Doi: 10.1128/spectrum.03557-23

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Structure of the recombinant RNA polymerase from African Swine Fever Virus

Authors: Simona Pilotto, Michal Sýkora, Gwenny Cackett, Christopher Dulson, Finn Werner

Journal: Nat Commun

PubMed ID: 38383525

Doi: 10.1038/s41467-024-45842-7

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Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization

Authors: Stephanie E Martinez, Amit V Pandey, Tania E Perez Jimenez, Zhaohui Zhu, Michael H Court

Journal: PLoS ONE

PubMed ID: 38300925

Doi: 10.1371/journal.pone.0297191

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Critical Aggregation Concentration Can be a Predictor of Doxorubicin Delivery Performance of Self-Assembling Amphiphilic Peptides with Different Hydrophobic Tails

Authors: Saeed Zanganeh, Loghman Firoozpour, Maryam Samareh Salavatipour, Soroush Sardari, Reza Ahangari Cohan, Nasir Mohajel

Journal: J Pharm Sci

PubMed ID: 38417791

Doi: 10.1016/j.xphs.2024.02.022

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Impact of Antenatal SARS-CoV-2 Exposure on SARS-CoV-2 Neutralization Potency

Authors: Chia-Jung Chiang, Wei-Lun Hsu, Mei-Tsz Su, Wen-Chien Ko, Keng-Fu Hsu, Pei-Yin Tsai

Journal: Vaccines (Basel)

PubMed ID: 38400147

Doi: 10.3390/vaccines12020164

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Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism

Authors: Yilin Ren, Xinyi Shi, Jing Mu, Shenyin Liu, Xin Qian, Wenlong Pei, Shanhong Ni, Zhengduo Zhang, Lei Li, Zhan Zhang

Journal: Food Funct

PubMed ID: 38236135

Doi: 10.1039/d3fo04347a

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A Divalent Chikungunya and Zika Nanovaccine with Thermostable Self-Assembly Multivalent Scaffold LS-SUMO

Authors: Qianlin Li, Jinsong Zhang, Qiang Deng, Conghui Liao, Jun Qian, Zeliang Chen, Jiahai Lu

Journal: Adv Healthc Mater

PubMed ID: 38340040

Doi: 10.1002/adhm.202303619

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Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons

Authors: Wenchao Gu, Sijin Luozhong, Simian Cai, Ketaki Londhe, Nadine Elkasri, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Yujie Yin, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Qiuming Yu, Melissa Warden, Robert Langer, Shaoyi Jiang

Journal: Nat Biomed Eng

PubMed ID: 38374224

Doi: 10.1038/s41551-023-01150-x

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Characterization of core oligosaccharide synthesis reveals novel aspects of lipooligosaccharide assembly

Authors: Leah M VanOtterloo, Luis A Macias, Matthew J Powers, Jennifer S Brodbelt, M Stephen Trent

Journal: MBio

PubMed ID: 38349180

Doi: 10.1128/mbio.03013-23

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Deciphering the origin of developmental stability: The role of intracellular expression variability in evolutionary conservation

Authors: Yui Uchida, Masato Tsutsumi, Shunsuke Ichii, Naoki Irie, Chikara Furusawa

Journal: Evol Dev

PubMed ID: 38414112

Doi: 10.1111/ede.12473

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Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I

Authors: Lisa Choy, Stephen Norris, Xiumin Wu, Ganesh Kolumam, Ari Firestone, Jeffrey Settleman, David Stokoe

Journal: Cancer Res Commun

PubMed ID: 38358346

Doi: 10.1158/2767-9764.CRC-23-0432

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CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy

Authors: Peixia Tang , Zhen Yu , Hao Sun 2, Lanting Liu , Lixin Gong , Teng Fang , Xiyue Sun , Shiyi Xie , Gang An 2, Zhenshu Xu 3, Lugui Qiu 4, Mu Hao

Journal: EBioMedicine

PubMed ID: 38199044

Doi: 10.1016/j.ebiom.2023.104961

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Increasing β-hexosaminidase A activity using genetically modified mesenchymal stem cells

Authors: Alisa A Shaimardanova , Daria S Chulpanova , Valeriya V Solovyeva 1, Shaza S Issa , Aysilu I Mullagulova , Angelina A Titova , Yana O Mukhamedshina , Anna V Timofeeva , Alexander M Aimaletdinov , Islam R Nigmetzyanov , Albert A Rizvanov

Journal: Neural Regen Res .

PubMed ID: 37488869

Doi: 10.4103/1673-5374.375328

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Minimalist Nanovaccine with Optimized Amphiphilic Copolymers for Cancer Immunotherapy

Authors: Le Niu , Yu Miao , Zhiqin Cao , Ting Wei , Jiafei Zhu , Maoyi Li , Boxiong Bai , Linfu Chen , Nanhui Liu , Feng Pan , Junjie Zhu , Cheng Wang , Yang Yang , Qian Chen

Journal: ACS Nano .

PubMed ID: 38230639

Doi: 10.1021/acsnano.3c10174

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Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide

Authors: Tian Xie , Feitong Dong , Gongshe Han , Xinyue Wu , Peng Liu , Zike Zhang , Jianlong Zhong , Somashekarappa Niranjanakumari , Kenneth Gable , Sita D Gupta , Wenchen Liu , Peter J Harrison , Dominic J Campopiano , Teresa M Dunn , Xin Gong

Journal: Cell Rep .

PubMed ID: 38285738

Doi: 10.1016/j.celrep.2024.113717

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Supramolecular Hydrogel with Ultra-Rapid Cell-Mediated Network Adaptation for Enhancing Cellular Metabolic Energetics and Tissue Regeneration

Authors: Zhuo Li, Boguang Yang, Zhengmeng Yang, Xian Xie, Zhengnan Guo, Jianyang Zhao, Ruinan Wang, Hao Fu, Pengchao Zhao, Xin Zhao, Guosong Chen, Gang Li, Fuxin Wei, Liming Bian

Journal: Adv Mater .

PubMed ID: 38295393

Doi: 10.1002/adma.202307176

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TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing

Authors: Kostantin Kiianitsa, Maria E Lukes, Brian J Hayes, Julianna Brutman, Paul N Valdmanis, Thomas D Bird, Wendy H Raskind, Olena Korvatska

Journal: Brain

PubMed ID: 38226698

Doi: 10.1093/brain/awae014

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mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer

Authors: No-Joon Song, Karthik B Chakravarthy, Hyeongseon Jeon, Chelsea Bolyard, Kelsi Reynolds, Kevin P Weller, Sarah Reisinger, Yi Wang, Anqi Li, Sizun Jiang, Qin Ma, Dan H Barouch, Mark P Rubinstein, Peter G Shields, Eugene M Oltz, Dongjun Chung, Zihai Li

Journal: J Immunother Cancer

PubMed ID: 38177076

Doi: 10.1136/jitc-2023-007922

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Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis

Authors: Xiao-Yu Ji, Yu-Xin Guo, Li-Bin Wang, Wen-Cheng Wu, Jia-Qi Wang, Jin He, Rui Gao, Javad Rasouli, Meng-Yuan Gao, Zhen-Hai Wang, Dan Xiao, Wei-Feng Zhang, Bogoljub Ciric, Yuan Zhang, Xing Li

Journal: J Neuroinflammation

PubMed ID: 38246987

Doi: 10.1186/s12974-024-03019-5

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A CRISPR-Cas12a-based electrochemical biosensor for the detection of microphthalmia-associated transcription factor

Authors: Qisheng Luo, Chunyuan Zhang, Xiandong Deng, Dongyuan Liu, Xingchen Pan, Yuanxun Gong, Qianli Tang, Kai Zhang, Xianjiu Liao

Journal: Mikrochim Acta

PubMed ID: 38170285

Doi: 10.1007/s00604-023-06164-5

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Cognitive impairment is associated with BDNF-TrkB signaling mediating synaptic damage and reduction of amino acid neurotransmitters in heart failure

Authors: Lei Wang, Ziwen Lu, Yu Teng, Weibing Pan, Yang Li, Sha Su, Jingling Chang, Mingjing Zhao

Journal: FASEB J

PubMed ID: 38085181

Doi: 10.1096/fj.202301699RR

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Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

Authors: Chia Ying Huang, Alexander Metz, Roland Lange, Nadia Artico, Céline Potot, Julien Hazemann, Manon Müller, Marina Dos Santos, Alain Chambovey, Daniel Ritz, Deniz Eris, Solange Meyer, Geoffroy Bourquin, May Sharpe, Aengus Mac Sweeney

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 38289714

Doi: 10.1107/S2059798324000329

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Structural basis of prostaglandin efflux by MRP4

Authors: Sergei Pourmal, Evan Green, Ruchika Bajaj, Ilan E Chemmama, Giselle M Knudsen, Meghna Gupta, Andrej Sali, Yifan Cheng, Charles S Craik, Deanna L Kroetz, Robert M Stroud

Journal: Nat Struct Mol Biol

PubMed ID: 38216659

Doi: 10.1038/s41594-023-01176-4

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Beta-1,3-Glucan-Binding Protein Inhibits Dengue and ZIKA Virus Replication

Authors: Xiaoxue Xie, Di Wang, Bo Li, Guorui Liang, Xiaoli Chen, Dan Xing, Teng Zhao, Xinyu Zhou, Chunxiao Li

Journal: Biomedicines

PubMed ID: 38255195

Doi: 10.3390/biomedicines12010088

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Increasing the Pentose Phosphate Pathway Flux to Improve Plasmid DNA Production in Engineered

Authors: Mitzi de la Cruz, Flavio Kunert, Hilal Taymaz-Nikerel, Juan-Carlos Sigala, Guillermo Gosset, Jochen Büchs, Alvaro R Lara

Journal: Microorganisms

PubMed ID: 38257977

Doi: 10.3390/microorganisms12010150

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Identification and application of an exocarp-preferential promoter for genetic engineering of tomato fruit

Authors: Xue-Ming Ruan, Xiangyu Xiong, Jian-Feng Li

Journal: Hortic Res

PubMed ID: 38544552

Doi: 10.1093/hr/uhae035

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Cluster-Enhanced Nanopore Sensing of Ovarian Cancer Marker Peptides in Urine

Authors: Thomas W Rockett, Mohammed Almahyawi, Madhav L Ghimire, Aashna Jonnalagadda, Victoria Tagliaferro, Sarah J Seashols-Williams, Massimo F Bertino, Gregory A Caputo, Joseph E Reiner

Journal: ACS Sens

PubMed ID: 38286995

Doi: 10.1021/acssensors.3c02207

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Combined biolistic and cell penetrating peptide delivery for the development of scalable intradermal DNA vaccines

Authors: Roizza Beth So, Gang Li, Victoria Brentville, Janet M Daly, James E Dixon

Journal: J Control Release

PubMed ID: 38244841

Doi: 10.1016/j.jconrel.2024.01.031

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Therapeutic effect of long-acting FGF21 with controlled site-specific modification on nonalcoholic steatohepatitis

Authors: Jianying Qi, Zhimou Guo, Shenglong Zhu, Xuan Jiang, Yuanyuan Wu, Yingli Chen, Fei Hu, Jingjing Xiong, YunZhou Wu, Xianlong Ye, Xinmiao Liang

Journal: Int J Biol Macromol

PubMed ID: 38290625

Doi: 10.1016/j.ijbiomac.2024.129797

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Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies

Authors: Ester Blanco, Noelia Silva-Pilipich, Ana Bocanegra, Luisa Chocarro, Antonio Procopio, Karina Ausín, Joaquín Fernandez-Irigoyen, Leticia Fernández, Nerea Razquin, Ana Igea, Maider Garnica, Miriam Echaide, Hugo Arasanz, Ruth Vera, David Escors, Cristian Smerdou, Grazyna Kochan

Journal: Br J Cancer

PubMed ID: 38195888

Doi: 10.1038/s41416-023-02561-y

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Glyoxylate reductase: Definitive identification in human liver mitochondria, its importance for the compartment-specific detoxification of glyoxylate

Authors: Sander F Garrelfs, Serhii Chornyi, Heleen Te Brinke, Jos Ruiter, Jaap Groothoff, Ronald J A Wanders

Journal: J Inherit Metab Dis

PubMed ID: 38200664

Doi: 10.1002/jimd.12711

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Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Authors: Giuseppe Rospo, Rosaria Chilà, Vittoria Matafora, Veronica Basso, Simona Lamba, Alice Bartolini, Angela Bachi, Federica Di Nicolantonio, Anna Mondino, Giovanni Germano, Alberto Bardelli

Journal: Genome Med

PubMed ID: 38243308

Doi: 10.1186/s13073-023-01275-3

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Hepatitis C virus E1 recruits high-density lipoprotein to support infectivity and evade antibody recognition

Authors: Jennifer Casiano Matos, Kaneemozhe Harichandran, Jingrong Tang, Denis O Sviridov, Giacomo Sidoti Migliore, Motoshi Suzuki, Lisa R Olano, Alvaro Hobbs, Ashish Kumar, Myeisha U Paskel, Mattia Bonsignori, Altaira D Dearborn, Alan T Remaley, Joseph Marcotrigiano

Journal: J Virol

PubMed ID: 38174935

Doi: 10.1128/jvi.00849-23

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The lncRNA HCG4 regulates the RIG-I-mediated IFN production to suppress H1N1 swine influenza virus replication

Authors: Jinghua Cheng, Jie Tao, Benqiang Li, Ying Shi, Huili Liu

Journal: Front Microbiol

PubMed ID: 38274760

Doi: 10.3389/fmicb.2023.1324218

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Predicting multiple conformations via sequence clustering and AlphaFold2

Authors: Hannah K Wayment-Steele, Adedolapo Ojoawo, Renee Otten, Julia M Apitz, Warintra Pitsawong, Marc Hömberger, Sergey Ovchinnikov, Lucy Colwell, Dorothee Kern

Journal: Nature

PubMed ID: 37956700

Doi: 10.1038/s41586-023-06832-9

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N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting

Authors: Thomas E Mulroney, Tuija Pöyry, Juan Carlos Yam-Puc, Maria Rust, Robert F Harvey, Lajos Kalmar, Emily Horner, Lucy Booth, Alexander P Ferreira, Mark Stoneley, Ritwick Sawarkar, Alexander J Mentzer, Kathryn S Lilley, C Mark Smales, Tobias von der Haar, Lance Turtle, Susanna Dunachie, Paul Klenerman, James E D Thaventhiran, Anne E Willis

Journal: Nature

PubMed ID: 38057663

Doi: 10.1038/s41586-023-06800-3

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Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

Authors: Rajeshwer S Sankhala , Kerri G Lal , Jaime L Jensen , Vincent Dussupt , Letzibeth Mendez-Rivera , Hongjun Bai , Lindsay Wieczorek , Sandra V Mayer , Michelle Zemil , Danielle A Wagner , Samantha M Townsley , Agnes Hajduczki , William C Chang , Wei-Hung Chen , Gina C Donofrio , Ningbo Jian , Hannah A D King , Cynthia G Lorang , Elizabeth J Martinez , Phyllis A Rees , Caroline E Peterson , Fabian Schmidt , Tricia J Hart , Debra K Duso , Lawrence W Kummer , Sean P Casey , Jazmean K Williams , Shruthi Kannan , Bonnie M Slike , Lauren Smith , Isabella Swafford , Paul V Thomas , Ursula Tran , Jeffrey R Currier , Diane L Bolton , Edgar Davidson , Benjamin J Doranz , Theodora Hatziioannou , Paul D Bieniasz , Dominic Paquin-Proulx , William W Reiley , Morgane Rolland , Nancy J Sullivan , Sandhya Vasan , Natalie D Collins , Kayvon Modjarrad , Gregory D Gromowski , Victoria R Polonis , Nelson L Michael , Shelly J Krebs , M Gordon Joyce

Journal: Nat Commun

PubMed ID: 38172512

Doi: 10.1038/s41467-023-44265-0.

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Therapeutic vaccination with lentiviral vector in HBV-persistent mice and two inactive HBsAg carriers

Authors: Yumeng Zhang, Maryline Bourgine , Yanmin Wan, Jieyu Song, Zongying Li, Yiqi Yu, Wangfang Jiang, Mingzhe Zhou, Cuiyuan Guo, Didier Santucci, Xiao Liang, Christian Brechot, Wenhong Zhang, Pierre Charneau, Hong Wu, Chao Qiu

Journal: Hepatology

PubMed ID: 37827470

Doi: 10.1016/j.jhep.2023.09.019

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A new antibiotic traps lipopolysaccharide in its intermembrane transporter

Authors: Karanbir S Pahil, Morgan S A Gilman, Vadim Baidin, Thomas Clairfeuille, Patrizio Mattei, Christoph Bieniossek, Fabian Dey, Dieter Muri, Remo Baettig, Michael Lobritz, Kenneth Bradley, Andrew C Kruse 4, Daniel Kahne 5

Journal: Nature

PubMed ID: 38172635

Doi: 10.1038/s41586-023-06799-7

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Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution

Authors: Jason Z. Zhang, William H. Nguyen, Nathan Greenwood, John C. Rose, Shao-En Ong, Dustin J. Maly & David Baker

Journal: Nature Biotechnol

PubMed ID: 38228150

Doi: 10.1038/s41587-023-02107-w

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Structure-guided discovery of anti-CRISPR and anti-phage defense proteins

Authors: Ning Duan , Emily Hand , Mannuku Pheko , Shikha Sharma , Akintunde Emiola

Journal: Nat Commun

PubMed ID: 38245560

Doi: 10.1038/s41467-024-45068-7

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Stabilization of the Metastable Pre-Fusion Conformation of the SARS-CoV-2 Spike Glycoprotein through N-Linked Glycosylation of the S2 Subunit

Authors: Fuwen Zan, Yao Zhou, Ting Chen , Yahan Chen, Zhixia Mu, Zhaohui Qian , Xiuyuan Ou

Journal: Viruses.

PubMed ID: 38399999

Doi: 10.3390/v16020223

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Modulations in the host cell proteome by the hantavirus nucleocapsid protein

Authors: Austin Royster, Songyang Ren, Saima Ali, Sheema Mir, Mohammad Mir

Journal: PLoS Pathog

PubMed ID: 38190410

Doi: 10.1371/journal.ppat.1011925

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A label-free high-throughput protein solubility assay and its application to Aβ40

Authors: Max Lindberg, Emil Axell, Emma Sparr, Sara Linse

Journal: Biophys Chem

PubMed ID: 38309218

Doi: 10.1016/j.bpc.2023.107165

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Identification of a novel B-cell epitope of the African swine fever virus p34 protein and development of an indirect ELISA for the detection of serum antibodies

Authors: Yuanyuan Tian, Chao Liang, Jingming Zhou, Fanglin Sun, Yankai Liu, Yumei Chen, Xifang Zhu, Hongliang Liu, Peiyang Ding, Enping Liu, Ying Zhang, Sixuan Wu, Aiping Wang

Journal: Front Microbiol

PubMed ID: 38282734

Doi: 10.3389/fmicb.2023.1308753

Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription

Authors: Qian Zhang, Wantae Kim, Svetlana Panina, Joshua E Mayfield, Bede Portz, Y Jessie Zhang

Journal: biorxiv

PubMed ID: 38260389

Doi: 10.1101/2024.01.01.573828

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Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma

Authors: Gagan Chhabra, Chandra K Singh, Mary A Ndiaye, Shengqin Su, Carl A Shirley, Nihal Ahmad

Journal: NPJ Precis Oncol

PubMed ID: 38184733

Doi: 10.1038/s41698-023-00493-7

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Mining and rational design of psychrophilic catalases using metagenomics and deep learning models

Authors: Shuning Wu, Guoshun Xu, Yongping Su, Huoqing Huang, Xinxin Xu, Yuhong Zhang, Jian Tian, Wei Zhang, Zhiwei Zhang, Bo Liu

Journal: Appl Microbiol Biotechnol

PubMed ID: 38175233

Doi: 10.1007/s00253-023-12926-1

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