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至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

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CoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels

Authors: Yin Liu, Xinyi Liu, Dongyi Wei, Lu Dang, Xiaoran Xu, Shisheng Huang, Liwen Li, Sanyun Wu, Jinxian Wu, Xiaoyan Liu, Wenjun Sun, Wanyu Tao, Yongchang Wei, Xingxu Huang, Kui Li, Xinjie Wang, Fuling Zhou

Journal: Nat Commun

PubMed ID: 38866774

Doi: 10.1038/s41467-024-49414-7

Products & Services: Gene Synthesis

Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria

Authors: Hunter L Abrahamsen, Tristan C Sanford, Casie E Collamore, Bronte A Johnstone, Michael J Coyne, Leonor García-Bayona, Michelle P Christie, Jordan C Evans, Allison J Farrand, Katia Flores, Craig J Morton, Michael W Parker, Laurie E Comstock, Rodney K Tweten

Journal: Nat Commun

PubMed ID: 38866748

Doi: 10.1038/s41467-024-49103-5

Products & Services: Recombinant Proteins

GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway

Authors: Jiahua Yang, Xuechuan Li, Shili Chen, Guoqiang Li, Peng Pu, Yang Yang, Wenguang Wu, Yajun Geng, Yingbin Liu

Journal: Cancer Lett

PubMed ID: 38942137

Doi: 10.1016/j.canlet.2024.217067

Products & Services: Custom Vector Construction

SepM mutation in Streptococcus mutans clinical isolates and related function analysis

Authors: Shanshan Liu, Yidan Shao, Zhenzhen Zhang, Wen Xu, Yudong Liu, Kai Zhang, Li Xu, Qingwei Zheng, Yu Sun

Journal: BMC Oral Health

PubMed ID: 38918777

Doi: 10.1186/s12903-024-04436-x

Products & Services: Gene Synthesis

OsNLP3 enhances grain weight and reduces grain chalkiness in rice

Authors: Liang-Qi Sun, Yu Bai, Jie Wu, Shi-Jun Fan, Si-Yan Chen, Zheng-Yi Zhang, Jin-Qiu Xia, Shi-Mei Wang, Yu-Ping Wang, Peng Qin, Shi-Gui Li, Ping Xu, Zhong Zhao, Cheng-Bin Xiang, Zi-Sheng Zhang

Journal: Plant Commun

PubMed ID: 38853433

Doi: 10.1016/j.xplc.2024.100999

Products & Services: Recombinant Proteins

M tuberculosis PrrA binds the dosR promoter and regulates mycobacterial adaptation to hypoxia

Authors: Yannik A Haller, Jiapei Jiang, Zijian Wan, Alexia Childress, Shaopeng Wang, Shelley E Haydel

Journal: Tuberculosis (Edinb)

PubMed ID: 38885567

Doi: 10.1016/j.tube.2024.102531

Products & Services: Custom Vector Construction

The Gene Network That Regulates Head Organizer Activity in Is Differentially Regulated in Epidermis and Gastrodermis

Authors: Laura Iglesias Ollé, Chrystelle Perruchoud, Paul Gerald Layague Sanchez, Matthias Christian Vogg, Brigitte Galliot

Journal: Biomedicines

PubMed ID: 38927481

Doi: 10.3390/biomedicines12061274

Products & Services: DNA Sequencing

Immuno-Microbial Signature of Vaccine-Induced Immunity against SARS-CoV-2

Authors: Lesley Umeda, Amada Torres, Braden P Kunihiro, Noelle C Rubas, Riley K Wells, Krit Phankitnirundorn, Rafael Peres, Ruben Juarez, Alika K Maunakea

Journal: Vaccines (Basel)

PubMed ID: 38932366

Doi: 10.3390/vaccines12060637

Products & Services: Gene Synthesis

Recombinant Art v401 protein produces immunological tolerance by subcutaneous immunotherapy in a wormwood pollen-driven allergic asthma female mouse model

Authors: Tao Wang, Jiaoni Chi, Zhimin Li, Yue Zhang, Yaojun Wang, Ming Ding, Bin Zhou, JiaChen Gui, Qiang Li

Journal: PLoS ONE

PubMed ID: 38941291

Doi: 10.1371/journal.pone.0280418

Products & Services: Molecular Biology Reagents

An optimized and robust workflow for quantifying the canonical histone ubiquitination marks H2AK119ub and H2BK120ub by LC-MS/MS

Authors: Mariana Lopes, Peder J Lund, Benjamin A Garcia

Journal: biorxiv

PubMed ID: 38915586

Doi: 10.1101/2024.06.11.596744

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Identification of a human type XVII collagen fragment with high capacity for maintaining skin health

Authors: Xinglong Wang, Shuyao Yu, Ruoxi Sun, Kangjie Xu, Kun Wang, Ruiyan Wang, Junli Zhang, Wenwen Tao, Shangyang Yu, Kai Linghu, Xinyi Zhao, Jingwen Zhou

Journal: Synth Syst Biotechnol

PubMed ID: 38911060

Doi: 10.1016/j.synbio.2024.06.001

Products & Services: Gene Synthesis

A novel BSL-2 Lassa virus reverse genetics system modelling the complete viral life cycle

Authors: Xiaoyou Hu, Xu Bai, Fangling Tian, Yifan Xing, Yi Shi, Yimin Tong, Jin Zhong

Journal: Emerg Microbes Infect

PubMed ID: 38747061

Doi: 10.1080/22221751.2024.2356149

Distance tuneable integral membrane protein containing floating bilayers directed self-assembly

Authors: Stephen C L Hall, David J Hardy, Éilís C Bragginton, Hannah Johnston, Tudor Onose, Rachel Holyfield, Pooja Sridhar, Timothy J Knowles, Luke A Clifton

Journal: Nanoscale

PubMed ID: 38940744

Doi: 10.1039/d3nr04622b

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Metabolic Engineering of for Production of Canthaxanthin, Zeaxanthin, and Astaxanthin

Authors: Peerada Promdonkoy, Akaraphol Watcharawipas, Suriyaporn Bubphasawan, Kitisak Sansatchanon, Nattida Suwanakitti, Kanokarn Kocharin, Weerawat Runguphan

Journal: J Fungi (Basel)

PubMed ID: 38921419

Doi: 10.3390/jof10060433

Products & Services: Codon Optimization

Structural basis for an early stage of the photosystem II repair cycle in Chlamydomonas reinhardtii

Authors: Anjie Li, Tingting You, Xiaojie Pang, Yidi Wang, Lijin Tian, Xiaobo Li & Zhenfeng Liu

Journal: Nature Communications

PubMed ID: 38890314

Doi: 10.1038/s41467-024-49532-2

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

A new anti-CRISPR gene promotes the spread of drug-resistance plasmids in Klebsiella pneumoniae

Authors: Chunyu Jiang, Chengzhi Yu, Shuyi Sun, Jiajia Lin, Mufeng Cai, Zhenquan Wei, Lingling Feng, Jianhui Li, Yan Zhang, Ke Dong ... Show moreAuthor Notes

Journal: Nucleic Acids Res

PubMed ID: 38888121

Doi: 10.1093/nar/gkae516

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Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems

Authors: Mehtap Bacioglu, Manuel Schweighauser, Derrick Gray, Sofia Lövestam, Taxiarchis Katsinelos, Annelies Quaegebeur, John van Swieten, Zane Jaunmuktane, Stephen W. Davies, Sjors H. W. Scheres, Michel Goedert, Bernardino Ghetti, and Maria Grazia Spillantini

Journal: Acta Neuropathologica

PubMed ID: 38886865

Doi: 10.1186/s40478-024-01813-z

Products & Services: Protein and Antibody Isolation

The pigeon circovirus evolution, epidemiology and interaction with the host immune system under One Loft Race rearing conditions

Authors: Tomasz Stenzel, Daria Dziewulska, Ewa Łukaszuk, Joy M Custer, Matthew D De Koch, Simona Kraberger, Arvind Varsani

Journal: Sci Rep

PubMed ID: 38877168

Doi: 10.1038/s41598-024-64587-3

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Improved protein splicing through viral passaging

Authors: Adam J Hume , Dylan J Deeney , John S Smetana , Jacquelyn Turcinovic , John H Connor , Marlene Belfort , Elke Mühlberger , Christopher W Lennon

Journal: MBio

PubMed ID: 38780266

Doi: 10.1128/mbio.00984-24

Products & Services: Gene Synthesis Mutagenesis Services

Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

Authors: Gi Young Lee, Jeongmin Song

Journal: Nat Commun

PubMed ID: 38898034

Doi: 10.1038/s41467-024-49590-6

Products & Services: Recombinant Proteins

IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates anti-tumor activity in mouse models of colorectal cancer

Authors: Jianbo Shen, Niliang Qian, Guili Xu, Xiaoqian Dou, Ying An, Cuima Yang, Yujie Liu, Yunhui Liu, Xiujie Pan, Jingjing Wang, Guijun Bai, Hao Chen, Xiaolin Zhu, Xin Gao, Guoxiong Zhou, Qinzhi Xu

Journal: Int Immunopharmacol

PubMed ID: 38878486

Doi: 10.1016/j.intimp.2024.112424

Products & Services: Protein and Antibody Isolation

Monoterpene-chalcone conjugates and diarylheptanoids isolated from the seeds of Alpinia katsumadai Hayata with cytotoxic activity

Authors: Hua-Lin You, Bo Zhou, Meng-Jia Guo, Xin-Man Zhao, Xiao-Long Li, Xiang-Chun Shen, Nen-Ling Zhang

Journal: Phytochemistry

PubMed ID: 38945281

Doi: 10.1016/j.phytochem.2024.114197

Products & Services: PCR Cloning and Subcloning

Plasmodium vivax serological exposure markers: PvMSP1-42-induced humoral and memory B-cell response generates long-lived antibodies

Authors: Feng Lu, Jiahui Xu, Yaobao Liu, Zhenyu Ren, Junhu Chen, Weijuan Gong, Yi Yin, Yinyue Li, Li Qian, Xinlong He, Xiu Han, Zhijie Lin, Jingyuan Lu, Wenwen Zhang, Jiali Liu, Didier Menard, Eun-Taek Han, Jun Cao

Journal: PLoS Pathog

PubMed ID: 38941356

Doi: 10.1371/journal.ppat.1012334

Products & Services: Protein and Antibody Isolation

A 14-amino acid cationic peptide Bolespleenin from the marine fish mudskipper Boleophthalmus pectinirostris exhibiting potent antimicrobial activity and therapeutic potential

Authors: Yuqi Bai, Weibin Zhang, Wenbin Zheng, Xin-Zhan Meng, Yingyi Duan, Chang Zhang, Fangyi Chen, Ke-Jian Wang

Journal: Biochem Pharmacol

PubMed ID: 38852647

Doi: 10.1016/j.bcp.2024.116344

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Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

Authors: Vadim A Klenchin, Natasha M Clark, Nida K Keles, Saverio Capuano, Rosemarie Mason, Guangping Gao, Aimee Broman, Emek Kose, Taina T Immonen, Christine M Fennessey, Brandon F Keele, Jeffrey D Lifson, Mario Roederer, Matthew R Gardner, David T Evans

Journal: biorxiv

PubMed ID: 38895320

Doi: 10.1101/2024.05.30.593694

Products & Services: Codon Optimization

The role of MASP1 in the complement system and expression characteristics in response to GCRV infection in grass carp

Authors: Yuling Wei, Zhao Lv, Tiaoyi Xiao, Zongjun Du

Journal: Fish Shellfish Immunol

PubMed ID: 38901682

Doi: 10.1016/j.fsi.2024.109712

Products & Services: Protein and Antibody Isolation

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

Authors: Qi Yang, Bao Xue, Fengjiang Liu, Yongzhi Lu, Jielin Tang, Mengrong Yan, Qiong Wu, Ruyi Chen, Anqi Zhou, Lijie Liu, Junjun Liu, Changbin Qu, Qingxin Wu, Muqing Fu, Jiayi Zhong, Jianwei Dong, Sijie Chen, Fan Wang, Yuan Zhou, Jie Zheng, Wei Peng, Jinsai Shang, Xinwen Chen

Journal: Signal Transduct Target Ther

PubMed ID: 38853183

Doi: 10.1038/s41392-024-01858-5

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Library-Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity

Authors: Shenlin Hsiao, Shuanghong Chen, Yanhong Jiang, Qiudao Wang, Yang Yang, Yongrong Lai, Tao Zhong, Jiaoyang Liao, Yuxuan Wu

Journal: Adv Sci (Weinh)

PubMed ID: 38874509

Doi: 10.1002/advs.202309004

Products & Services: Molecular Biology Reagents

Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging

Authors: Seokjo Kang, Emily Y Ko, Amelia E Andrews, Juliana E Shin, Karina J Nance, Pijus K Barman, Peter S Heeger, Willard M Freeman, Bérénice A Benayoun, Helen S Goodridge

Journal: J Neuroinflammation

PubMed ID: 38840206

Doi: 10.1186/s12974-024-03130-7

Products & Services: Protein Electrophoresis and Western

Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension

Authors: Shan-Shan Zhang, Lance Larrabee, Andrew H Chang, Sapna Desai, Lisa Sloan, Xin Wang, Yixuan Wu, Nazia Parvez, Karen Amaratunga, Allison C Hartman, Abby Whitnall, Joseph Mason, Nicholas P Barton, Audrey Y Chu, Jonathan M Davitte, Adam J Csakai, Caitlin Vestal Tibbetts, Audrey E Tolbert, Heather O'Keefe, Jessie Polanco, Joseph Foley, Casey Kmett, Jonathan Kehler, Gabriela Kozejova, Feng Wang, Andrew P Mayer, Patrick Koenig, Davide Foletti, Steven J Pitts, Christine G Schnackenberg

Journal: Sci Rep

PubMed ID: 38851835

Doi: 10.1038/s41598-024-62804-7

Products & Services: Molecular Biology Reagents

A phage nucleus-associated protein from the jumbophage Churi inhibits bacterial growth through protein translation interference

Authors: Wichanan Wannasrichan, Sucheewin Krobthong, Chase J Morgan, Emily G Armbruster, Milan Gerovac, Yodying Yingchutrakul, Patompon Wongtrakoongate, Jörg Vogel, Chanat Aonbangkhen, Poochit Nonejuie, Joe Pogliano, Vorrapon Chaikeeratisak

Journal: biorxiv

PubMed ID: 38915640

Doi: 10.1101/2024.06.15.599175

Products & Services: Molecular Biology Reagents

Heterologous booster vaccination enhances antibody responses to SARS-CoV-2 by improving Tfh function and increasing B-cell clonotype SHM frequency

Authors: Yanli Song, Jiaolei Wang, Zhihui Yang, Changgui Li

Journal: Frontiers in Immunology

Doi: 10.3389/fimmu.2024.1406138

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Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function

Authors: Zichao Zhang , Jing Chen , Rongze Ma , Chongshen Xu , Yunzhe Lu , Jiecan Zhou , Kun Xia , Pengfei Lu

Journal: Adv Sci (Weinh)

PubMed ID: 38884279

Doi: 10.1002/advs.202308822

Products & Services: Recombinant Proteins

A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and sarbecoviruses

Authors: Yingdan Wang # 1 2, Aihua Hao # 1, Ping Ji # 1, Yunping Ma # 1 3, Zhaoyong Zhang # 4, Jiali Chen 1, Qiyu Mao 1, Xinyi Xiong 4, Palizhati Rehati 1, Yajie Wang 1, Yanqun Wang 4, Yumei Wen 1, Lu Lu 1, Zhenguo Chen 1, Jincun Zhao 5 6, Fan Wu 7, Jinghe Huang 8 9, Lei Sun 10

Journal: Nat Commun

PubMed ID: 38879565

Doi: 10.1038/s41467-024-49096-1

Products & Services: Gene Synthesis

Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15

Authors: Zhongyuan Zhang , You Zheng , Lu Xu , Yang Yue , Kexin Xu , Fei Li 1, Fei Xu

Journal: Cell Discov

PubMed ID: 38918398

Doi: 10.1038/s41421-024-00698-5

Products & Services: Peptide Synthesis

The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer

Authors: Pengfei Yan , Xi Lin , Lijie Wu , Lu Xu , Fei Li , Junlin Liu , Fei Xu

Journal: Nat Commun

PubMed ID: 38898050

Doi: 10.1038/s41467-024-49625-y

Products & Services: Gene Synthesis

Development of GPC3-CAR-NK cells and optimization as a therapy for HCC

Authors: Bihui Cao, Qianqian Ni, Zhuxin Chen, Shuo Yang, Xinkui Zhang, Haotao Su, Zhenfeng Zhang, Qi Zhao, Xiaolan Zhu, Manting Liu

Journal: J Leukoc Biol

PubMed ID: 38922297

Doi: 10.1093/jleuko/qiae144

Products & Services: Molecular Biology Reagents

Androgen-responsive FOXP4 is a target for endometrial carcinoma

Authors: Kayo Kayahashi, Mahadi Hasan, Anowara Khatun, Susumu Kohno, Jumpei Terakawa, Shin-Ichi Horike, Natsumi Toyoda, Ayumi Matsuoka, Takashi Iizuka, Takeshi Obata, Masanori Ono, Yasunari Mizumoto, Chiaki Takahashi, Hiroshi Fujiwara, Takiko Daikoku

Journal: Commun Biol

PubMed ID: 38890503

Doi: 10.1038/s42003-024-06433-w

Products & Services: Molecular Biology Reagents

Molecular determinants of olfactory receptor activation: Comparative analysis of Olfr205 and Olfr740 family member responses to indole

Authors: Guangyao Li, Li Wang, Fangzhou Ye, Shengju Li, Hongmeng Yu

Journal: Arch Biochem Biophys

PubMed ID: 38880319

Doi: 10.1016/j.abb.2024.110061

Products & Services: Molecular Biology Reagents

Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering

Authors: Mona Alharbi, Andrew Lai, Nihar Godbole, Dominic Guanzon, Soumyalekshmi Nair, Felipe Zuñiga, Alexander Quinn, Mengliu Yang, Sherry Y Wu, Carlos Salomon

Journal: Int J Cancer

PubMed ID: 38848494

Doi: 10.1002/ijc.35055

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Selenium nanoparticles enhance mucosal immunity against Mycobacterium bovis infection

Authors: Xin Ge, Zhengmin Liang, Kui Li, Yuhui Dong, Yuanzhi Wang, Yiduo Liu, ZiYi Liu, Haoran Wang, Yue Nan, SiYan Chen, Lin Li, Yanbin Guo, Xiangmei Zhou

Journal: Int Immunopharmacol

PubMed ID: 38878484

Doi: 10.1016/j.intimp.2024.112384

Products & Services: Molecular Biology Reagents

Epitope-specific antibody fragments block aggregation of AGelD187N, an aberrant peptide in gelsolin amyloidosis

Authors: Laura Leimu, Patrik Holm, Anna Gąciarz, Oskar Haavisto, Stuart Prince, Ullamari Pesonen, Tuomas Huovinen, Urpo Lamminmäki

Journal: J Biol Chem

PubMed ID: 38944121

Doi: 10.1016/j.jbc.2024.107507

Products & Services: Protein and Antibody Isolation

Baculovirus surface display of a chimeric E-NS1 protein of YFV protects against YFV infection

Authors: Carla Tomatis, María Florencia Ferrer, Silvia Aquila, Pablo Daniel Thomas, Paula Nazarena Arrías, Leticia Ferrelli, Matías Pidre, Victor Romanowski, Eugenio Antonio Carrera Silva, Ricardo Martín Gómez

Journal: Vaccine

PubMed ID: 38852036

Doi: 10.1016/j.vaccine.2024.06.013

Products & Services: Catalog Antibodies

Electrophysiological Impact of SARS-CoV-2 Envelope Protein in U251 Human Glioblastoma Cells: Possible Implications in Gliomagenesis?

Authors: Lorenzo Monarca, Francesco Ragonese, Andrea Biagini, Paola Sabbatini, Matteo Pacini, Alessandro Zucchi, Roberta Spaccapelo, Paola Ferrari, Andrea Nicolini, Bernard Fioretti

Journal: Int J Mol Sci

PubMed ID: 38928376

Doi: 10.3390/ijms25126669

Products & Services: Gene Synthesis

PAM-flexible Engineered FnCas9 variants for robust and ultra-precise genome editing and diagnostics

Authors: Sundaram Acharya, Asgar Hussain Ansari, Prosad Kumar Das, Seiichi Hirano, Meghali Aich, Riya Rauthan, Sudipta Mahato, Savitri Maddileti, Sajal Sarkar, Manoj Kumar, Rhythm Phutela, Sneha Gulati, Abdul Rahman, Arushi Goel, C Afzal, Deepanjan Paul, Trupti Agrawal, Vinay Kumar Pulimamidi, Subhadra Jalali, Hiroshi Nishimasu, Indumathi Mariappan, Osamu Nureki, Souvik Maiti, Debojyoti Chakraborty

Journal: Nat Commun

PubMed ID: 38942756

Doi: 10.1038/s41467-024-49233-w

Products & Services: Gene Synthesis

Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity

Authors: Siddhi Omkar, Courtney Shrader, Joel R Hoskins, Jake T Kline, Megan M Mitchem, Luca Fornelli, Sue Wickner, Andrew W Truman

Journal: biorxiv

PubMed ID: 38915721

Doi: 10.1101/2024.06.13.598777

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miR-520e and its promoter region DNA methylation as potential biomarkers in atherosclerosis

Authors: Mimi Mu, Gao Liu, Xiaoyu Ding, Lijun Xue, Dandan Li, Yunhua Zhu, Nan Zhang, Jia Wu, Junjun Wang

Journal: Biochem Cell Biol

PubMed ID: 38917487

Doi: 10.1139/bcb-2023-0326

Products & Services: Molecular Biology Reagents

Experimental inoculation of pigs with monkeypox virus results in productive infection and transmission to sentinels

Authors: Emily Mantlo, Jessie D Trujillo, Natasha N Gaudreault, Igor Morozov, Charles E Lewis, Franco Matias-Ferreyra, Chester McDowell, Dashzeveg Bold, Taeyong Kwon, Konner Cool, Velmurugan Balaraman, Daniel Madden, Bianca Artiaga, Jayme Souza-Neto, Jeffrey B Doty, Mariano Carossino, Udeni Balasuriya, William C Wilson, Nikolaus Osterrieder, Lisa Hensley, Juergen A Richt

Journal: Emerg Microbes Infect

PubMed ID: 38712637

Doi: 10.1080/22221751.2024.2352434

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Effect of TIMPs and Their Minimally Engineered Variants in Blocking Invasion and Migration of Brain Cancer Cells

Authors: Elham Taheri, Maryam Raeeszadeh-Sarmazdeh

Journal: biorxiv

PubMed ID: 38895489

Doi: 10.1101/2024.06.05.597644

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H3N2 canine influenza virus-like particle vaccine with great protection in beagle dogs

Authors: Fei-Fei Ge, Li-Pin Shen, De-Quan Yang, Xian-Cao Yang, Xin Li, Hai-Xiao Shen, Jian Wang, Shixin Huang

Journal: Microbiol Spectr

PubMed ID: 38874403

Doi: 10.1128/spectrum.00445-24

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Prokaryotic RNA N1-Methyladenosine Erasers Maintain tRNA m1A Modification Levels in

Authors: Marcus Foo, Luke R Frietze, Behnam Enghiad, Yujie Yuan, Christopher D Katanski, Huimin Zhao, Tao Pan

Journal: ACS Chem Biol

PubMed ID: 38912606

Doi: 10.1021/acschembio.4c00278

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Identification of a novel glycoside hydrolase family 8 xylanase from Deinococcus geothermalis and its application at low temperatures

Authors: Tingting Wang, Min Lin, Yongliang Yan, Shijie Jiang, Qilin Dai, Zhengfu Zhou, Jin Wang

Journal: Arch Microbiol

PubMed ID: 38884653

Doi: 10.1007/s00203-024-04055-8

Products & Services: Protein and Antibody Isolation

Transgenic Soybean for Production of Thermostable α-Amylase

Authors: Zhenyan Cao, Ye Jiang, Jiajie Li, Ting Zheng, Chaoyang Lin, Zhicheng Shen

Journal: Plants (Basel)

PubMed ID: 38891347

Doi: 10.3390/plants13111539

Products & Services: Recombinant Proteins

Scaffold-enabled high-resolution cryo-EM structure determination of RNA

Authors: Daniel B Haack, Boris Rudolfs, Shouhong Jin, Kevin M Weeks, Navtej Toor

Journal: biorxiv

PubMed ID: 38915706

Doi: 10.1101/2024.06.10.598011

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Arboviruses antagonize insect Toll antiviral immune signaling to facilitate the coexistence of viruses with their vectors

Authors: Dongsheng Jia, Guozhong Luo, Heran Guan, Tingting Yu, Xinyan Sun, Yu Du, Yiheng Wang, Hongyan Chen, Taiyun Wei

Journal: PLoS Pathog

PubMed ID: 38865374

Doi: 10.1371/journal.ppat.1012318

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Auxin resistant 2 and short hypocotyl 2 regulate cotton fiber initiation and elongation

Authors: Fei Jin, Liping Zhu, Liyong Hou, Hongbin Li, Ling Li, Guanghui Xiao

Journal: Plant Physiol

PubMed ID: 38527791

Doi: 10.1093/plphys/kiae183

Products & Services: Protein and Antibody Isolation

Circ_002033 Regulates Proliferation, Apoptosis, and Oxidative Damage of Bovine Mammary Epithelial Cells via the miR-199a-5p-MAP3K11 Axis in Heat Stress

Authors: Hanfang Zeng, Shujie Li, Haomiao Chang, Yunfei Zhai, Haihui Wang, Hantong Weng, Zhaoyu Han

Journal: J Agric Food Chem

PubMed ID: 38869955

Doi: 10.1021/acs.jafc.3c09835

Products & Services: Protein and Antibody Isolation

Immune responses and reinfection of SARS-CoV-2 Omicron variant in patients with lung cancer

Authors: Chen Chen, Xiaoyun Zhou, Xiaoxing Gao, Ruili Pan, Qi He, Xiaobei Guo, Siyuan Yu, Na Wang, Qian Zhao, Mengzhao Wang, Yan Xu, Xiaohong Han

Journal: Int J Cancer

PubMed ID: 38837354

Doi: 10.1002/ijc.35038

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New wheat straw fermentation feed: recombinant efficient degradation of lignocellulose and increase feed protein

Authors: Xihua Chen, Xiaoyu Liang, Na Shi, Lu He, Yi Ma, Daochen Zhu, Zhong Ni, Huayou Chen

Journal: Prep Biochem Biotechnol

PubMed ID: 38824495

Doi: 10.1080/10826068.2024.2353637

Products & Services: Gene Synthesis

Structure of the E. coli nucleoid-associated protein YejK reveals a novel DNA binding clamp

Authors: Maria A Schumacher, Rajiv R Singh, Raul Salinas

Journal: Nucleic Acids Res

PubMed ID: 38832628

Doi: 10.1093/nar/gkae459

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Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Authors: Olawale G Raimi, Hina Ojha, Kenneth Ehses, Verena Dederer, Sven M Lange, Cristian Polo Rivera, Tom D Deegan, Yinchen Chen, Melanie Wightman, Rachel Toth, Karim P M Labib, Sebastian Mathea, Neil Ranson, Rubén Fernández-Busnadiego, Miratul M K Muqit

Journal: SCIENCE ADVANCES

PubMed ID: 38848361

Doi: 10.1126/sciadv.adn7191

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TnpB homologues exapted from transposons are RNA-guided transcription factors

Authors: Tanner Wiegand, Florian T Hoffmann, Matt W G Walker, Stephen Tang, Egill Richard, Hoang C Le, Chance Meers, Samuel H Sternberg

Journal: Nature

PubMed ID: 38926585

Doi: 10.1038/s41586-024-07598-4

Understanding the Phase Behavior of a Multistimuli-Responsive Elastin-like Polymer: Insights from Dynamic Light Scattering Analysis

Authors: Peter C Swanson, Galen P Arnold, Carolyn E Curley, Savannah C Wakita, Jeffery D V Waters, Eva Rose M Balog

Journal: J Phys Chem B

PubMed ID: 38830627

Doi: 10.1021/acs.jpcb.4c00070

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Production of norovirus-, rotavirus-, and enterovirus-like particles in insect cells is simplified by plasmid-based expression

Authors: Vili Lampinen, Stina Gröhn, Nina Lehmler, Minne Jartti, Vesa P Hytönen, Maren Schubert, Minna M Hankaniemi

Journal: Sci Rep

PubMed ID: 38937523

Doi: 10.1038/s41598-024-65316-6

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C-terminal Poly-histidine Tags Alter Escherichia coli Polyphosphate Kinase Activity and Susceptibility to Inhibition

Authors: Marvin Q Bowlin, Avery D Lieber, Abagail R Long, Michael J Gray

Journal: J Mol Biol

PubMed ID: 38866092

Doi: 10.1016/j.jmb.2024.168651

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IgE-Mediated Sensitization to Blo t 21 and Blo t 5 Is Associated With Asthma in the Tropics: A Case-Control Study

Authors: J Zakzuk, K Donado, E Mondol, V Marrugo, R Regino, J F López, K Hernandez, D Mercado, R Dennis, L Puerta, L Caraballo

Journal: J Investig Allergol Clin Immunol

PubMed ID: 38888580

Doi: 10.18176/jiaci.0892

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A soybean cyst nematode suppresses microbial plant symbionts using a lipochitooligosaccharide-hydrolysing enzyme

Authors: Wei Chen, Di Wang, Shaoyong Ke, Yangrong Cao, Wensheng Xiang, Xiaoli Guo, Qing Yang

Journal: Nat Microbiol

PubMed ID: 38886584

Doi: 10.1038/s41564-024-01727-5

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Development of a Ferritin Protein Nanoparticle Vaccine with PRRSV GP5 Protein

Authors: Xinjian Chang, Jun Ma, Yanrong Zhou, Shaobo Xiao, Xun Xiao, Liurong Fang

Journal: Viruses

PubMed ID: 38932282

Doi: 10.3390/v16060991

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Functional characterization of a cystatin A from the bat Myotis davidii

Authors: Gabriel Cerqueira Alves Costa, Ricardo Jose Soares Torquato, Vinícius de Morais Gomes, Lívia Rosa-Fernandes, Giuseppe Palmisano, Aparecida Sadae Tanaka

Journal: Comp Biochem Physiol B Biochem Mol Biol

PubMed ID: 38936799

Doi: 10.1016/j.cbpb.2024.111003

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Assessing Predictive Value of SARS-CoV-2 Epitope-Specific CD8 T-Cell Response in Patients with Severe Symptoms

Authors: Cristina Martín-Martín, Estefanía Salgado Del Riego, Jose R Vidal Castiñeira, Maria Soledad Zapico-Gonzalez, Mercedes Rodríguez-Pérez, Viviana Corte-Iglesias, Maria Laura Saiz, Paula Diaz-Bulnes, Dolores Escudero, Beatriz Suárez-Alvarez, Carlos López-Larrea

Journal: Vaccines (Basel)

PubMed ID: 38932408

Doi: 10.3390/vaccines12060679

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Discovery, characterization, and comparative analysis of new UGT72 and UGT84 family glycosyltransferases

Authors: Tuo Li, Annika J E Borg, Leo Krammer, Hansjörg Weber, Rolf Breinbauer, Bernd Nidetzky

Journal: Commun Chem

PubMed ID: 38942997

Doi: 10.1038/s42004-024-01231-1

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DNA mismatch and damage patterns revealed by single-molecule sequencing

Authors: Mei Hong Liu, Benjamin M Costa, Emilia C Bianchini, Una Choi, Rachel C Bandler, Emilie Lassen, Marta Grońska-Pęski, Adam Schwing, Zachary R Murphy, Daniel Rosenkjær, Shany Picciotto, Vanessa Bianchi, Lucie Stengs, Melissa Edwards, Nuno Miguel Nunes, Caitlin A Loh, Tina K Truong, Randall E Brand, Tomi Pastinen, J Richard Wagner, Anne-Bine Skytte, Uri Tabori, Jonathan E Shoag, Gilad D Evrony

Journal: Nature

PubMed ID: 38867045

Doi: 10.1038/s41586-024-07532-8

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Development of Broad-Spectrum Nanobodies for the Therapy and Diagnosis of SARS-CoV-2 and Its Multiple Variants

Authors: Lei He, Qian Wu, Zhaoyong Zhang, Lingling Chen, Kuai Yu, Leibin Li, Qiong Jia, Yanqun Wang, Jianqiang Ni, Chuanbin Wang, Qi Li, Xinyan Zhai, Jincun Zhao, Yuliang Liu, Ruiwen Fan, Yi-Ping Li

Journal: Mol Pharm

PubMed ID: 38920116

Doi: 10.1021/acs.molpharmaceut.4c00165

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Synthetic Peptides Elicit Humoral Response against Porcine Reproductive and Respiratory Syndrome Virus in Swine

Authors: Francisco Perez-Duran, Fernando Calderon-Rico, Luis Enrique Franco-Correa, Alicia Gabriela Zamora-Aviles, Roberto Ortega-Flores, Daniel Durand-Herrera, Alejandro Bravo-Patiño, Ricarda Cortes-Vieyra, Ilane Hernandez-Morales, Rosa Elvira Nuñez-Anita

Journal: Vaccines (Basel)

PubMed ID: 38932381

Doi: 10.3390/vaccines12060652

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mRNA Vaccine for Alzheimer's Disease: Pilot Study

Authors: Armine Hovakimyan, Garri Chilingaryan, Olga King, Joia Kai Capocchi, Jean Paul Chadarevian, Hayk Davtyan, Roman Kniazev, Michael G Agadjanyan, Anahit Ghochikyan

Journal: Vaccines (Basel)

PubMed ID: 38932388

Doi: 10.3390/vaccines12060659

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Exploring a novel GH13_5 α-amylase from Jeotgalibacillus malaysiensis D5 for raw starch hydrolysis

Authors: Nurfatini Radzlin, Mohd Shukuri Mohamad Ali, Kian Mau Goh, Amira Suriaty Yaakop, Iffah Izzati Zakaria, Ummirul Mukminin Kahar

Journal: AMB Express

PubMed ID: 38874807

Doi: 10.1186/s13568-024-01722-3

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Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome

Authors: Boyang Zhao, Zhongzheng Cao, Yi Zheng, Phuong Nguyen, Alisa Bowen, Robert H Edwards, Robert M Stroud, Yi Zhou, Menno Van Lookeren Campagne, Fei Li

Journal: Nat Commun

PubMed ID: 38918376

Doi: 10.1038/s41467-024-49614-1

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Double promoter and tandem gene strategy for efficiently expressing recombinant FGF21

Authors: Longying Liu, Nuoyi Ning, Simeng Xu, Dongqing Chen, Luping Zhou, Zhimou Guo, Xinmiao Liang, Xianlong Ye

Journal: Microb Cell Fact

PubMed ID: 38867280

Doi: 10.1186/s12934-024-02447-5

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NbPTR1 confers resistance against Pseudomonas syringae pv actinidiae in kiwifruit

Authors: Shin-Mei Yeh, Minsoo Yoon, Sidney Scott, Abhishek Chatterjee, Lauren M Hemara, Ronan K Y Chen, Tianchi Wang, Kerry Templeton, Erik H A Rikkerink, Jay Jayaraman, Cyril Brendolise

Journal: Plant Cell Environ

PubMed ID: 38899426

Doi: 10.1111/pce.15002

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Interleukin-1 beta (IL-1β) as adjuvant enhances the immune effects of Aeromonas veronii inactivated vaccine in largemouth bass (Micropterus salmoides)

Authors: Ze-Sheng Zhang, Heng-Chu Ren, Xie Gu, Qian-Rong Liang, Hui Fei, Yu-Hong Yang, Shun Yang, Liang-Yin He, Li-Li Liu

Journal: Int J Biol Macromol

PubMed ID: 38876231

Doi: 10.1016/j.ijbiomac.2024.133135

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Structural Basis for Recognition of the FLAG-tag by Anti-FLAG M2

Authors: J Wouter Beugelink, Els Sweep, Bert J C Janssen, Joost Snijder, Matti F Pronker

Journal: J Mol Biol

PubMed ID: 38852931

Doi: 10.1016/j.jmb.2024.168649

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Red2Flpe-SCON: a versatile, multicolor strategy for generating mosaic conditional knockout mice

Authors: Szu-Hsien Sam Wu, Somi Kim, Heetak Lee, Ji-Hyun Lee, So-Yeon Park, Réka Bakonyi, Isaree Teriyapirom, Natalia Hallay, Sandra Pilat-Carotta, Hans-Christian Theussl, Jihoon Kim, Joo-Hyeon Lee, Benjamin D Simons, Jong Kyoung Kim, Gabriele Colozza, Bon-Kyoung Koo

Journal: Nat Commun

PubMed ID: 38862535

Doi: 10.1038/s41467-024-49382-y

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Cost-Efficient Expression of Human Cardiac Myosin Heavy Chain in C2C12 Cells with a Non-Viral Transfection Reagent

Authors: Albin E Berg, Lok Priya Velayuthan, Alf Månsson, Marko Ušaj

Journal: Int J Mol Sci

PubMed ID: 38928453

Doi: 10.3390/ijms25126747

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CircVIRMA enhances cell malignant behavior by governing the miR-452-5p/CREBRF pathway in cervical cancer

Authors: Chengluo Hao, Jianjun Han, Kechao Xiang, Yun Wang, Xiangrui Chen, Chen Yang, Ailin Liang, Li Jia

Journal: Naunyn Schmiedebergs Arch Pharmacol

PubMed ID: 38850300

Doi: 10.1007/s00210-024-03159-8

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Preamplification-free ultra-fast and ultra-sensitive point-of-care testing via LwaCas13a

Authors: Wanting Zeng, Wanping Chen, Yang Liu, Ting Zhang, Chao Zhai, Wenqiang Li, Longyu Wang, Cheng Zhang, Qili Zeng, Fei Wang, Lixin Ma

Journal: Biosens Bioelectron

PubMed ID: 38776799

Doi: 10.1016/j.bios.2024.116400

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Micro-and nano-plastics induce kidney damage and suppression of innate immune function in zebrafish (Danio rerio) larvae

Authors: Hui Yang, Jian Ju, Yuting Wang, Zhu Zhu, Wenyan Lu, Yingying Zhang

Journal: Sci Total Environ

PubMed ID: 38703841

Doi: 10.1016/j.scitotenv.2024.172952

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Intranasal vaccination with an NDV-vectored SARS-CoV-2 vaccine protects against Delta and Omicron challenges

Authors: Bryce M Warner, Jacob G E Yates, Robert Vendramelli, Thang Truong, Courtney Meilleur, Lily Chan, Alexander Leacy, Phuc H Pham, Yanlong Pei, Leonardo Susta, Sarah K Wootton, Darwyn Kobasa

Journal: npj Vaccines

PubMed ID: 38782986

Doi: 10.1038/s41541-024-00870-8

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Development and characterization of an antibody that recognizes influenza virus N1 neuraminidases

Authors: Nan Chen, Renxi Wang, Wanlu Zhu, Xiangjun Hao, Jing Wang, Guojiang Chen, ChunXia Qiao, Xinying Li, Chenghua Liu, Beifen Shen, Jiannan Feng, Lihui Chai, Zuyin Yu, He Xiao

Journal: PLoS ONE

PubMed ID: 38723016

Doi: 10.1371/journal.pone.0302865

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Design, Construction, and Validation of a Yeast-Displayed Chemically Expanded Antibody Library

Authors: Arlinda Rezhdo, Rebecca L Hershman, James A Van Deventer

Journal: biorxiv

PubMed ID: 38853888

Doi: 10.1101/2024.05.29.596443

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Temperature-dependent iron motion in extremophile rubredoxins - no need for 'corresponding states'

Authors: Francis E Jenney, Hongxin Wang, Simon J George, Jin Xiong, Yisong Guo, Leland B Gee, Juan José Marizcurrena, Susana Castro-Sowinski, Anna Staskiewicz, Yoshitaka Yoda, Michael Y Hu, Kenji Tamasaku, Nobumoto Nagasawa, Lei Li, Hiroaki Matsuura, Tzanko Doukov, Stephen P Cramer

Journal: Sci Rep

PubMed ID: 38806591

Doi: 10.1038/s41598-024-62261-2

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Tetrahydroxy stilbene glucoside rejuvenates aging hematopoietic stem cells with predilection for lymphoid differentiation via AMPK and Tet2

Authors: Dan Gao, Wei-Wei Yi, Bo Liu, Cong-En Zhang, Cui-Cui Yang, Li Zeng, Lin Li, Guangbin Luo, Lan Zhang, Zhen-Yu Ju, Jia-Bo Wang

Journal: J Adv Res

PubMed ID: 38704089

Doi: 10.1016/j.jare.2024.04.027

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CRTAC1 identified as a promising diagnosis and prognostic biomarker in lung adenocarcinoma

Authors: Lin Tan, Han Zhang, Yun Ding, Yangyun Huang, Daqiang Sun

Journal: Sci Rep

PubMed ID: 38755183

Doi: 10.1038/s41598-024-61804-x

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Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4

Authors: Jianyao Zeng, Yuan Fang, Zixuan Zhang, Zhenzhen Lv, Xiaodie Wang, Qian Huang, Zhidan Tian, Jiaguo Li, Wenfeng Xu, Weimin Zhu, Jing Yu, Tao Liu, Qijun Qian

Journal: Oncogene

PubMed ID: 38806619

Doi: 10.1038/s41388-024-03066-5

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A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy

Authors: Dan A Tudorica, Bishal Basak, Alexia S Puerta Cordova, Grace Khuu, Kevin Rose, Michael Lazarou, Erika L F Holzbaur, James H Hurley

Journal: J Cell Biol

PubMed ID: 38728007

Doi: 10.1083/jcb.202309015

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Computer-Aided Semi-Rational Design to Enhance the Activity of l-Sorbosone Dehydrogenase from Gluconobacter oxidans WSH-004

Authors: Dong Li, Xinglong Wang, Lin Huo, Weizhu Zeng, Jianghua Li, Jingwen Zhou

Journal: J Agric Food Chem

PubMed ID: 38701424

Doi: 10.1021/acs.jafc.3c08365

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Engineered probiotics with sustained release of interleukin-2 for the treatment of inflammatory bowel disease after oral delivery

Authors: Maoyi Li, Nanhui Liu, Jiafei Zhu, Yumin Wu, Le Niu, Yi Liu, Linfu Chen, Boxiong Bai, Yu Miao, Yang Yang, Qian Chen

Journal: Biomaterials

PubMed ID: 38735180

Doi: doi.org/10.1016/j.biomaterials.2024.122584

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Cholesterol neutralized vemurafenib treatment by promoting melanoma stem‑like cells via its metabolite 27‑hydroxycholesterol

Authors: Xiaohong Wang, Feiliang Zhong, Tingting Chen, Hongbo Wang, Weifang Wang, Hongkai Jin, Chouyang Li, Xuan Guo, Ying Liu, Yu Zhang, Bo Li

Journal: Cell Mol Life Sci

PubMed ID: 38775844

Doi: 10.1007/s00018-024-05267-3

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Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry

Authors: Sarah Fox, Antoine Gaudreau-LaPierre, Ryan Reshke, Irina Podinic, Derrick J Gibbings, Laura Trinkle-Mulcahy, John W Copeland

Journal: Int J Mol Sci

PubMed ID: 38891874

Doi: 10.3390/ijms25115686

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ICG-labeled PD-L1-antagonistic affibody dimer for tumor imaging and enhancement of tumor photothermal-immunotherapy

Authors: Dianlong Jia, Shiqi Zhao, Huimin Liu, Xinyu Zhan, Zhongxia Zhou, Mingjia Lv, Xiufeng Tang, Wen Guo, Hui Li, Lilan Sun, Yidong Zhong, Baoqing Tian, Dandan Yuan, Xiaohui Tang, Qing Fan

Journal: Int J Biol Macromol

PubMed ID: 38704065

Doi: 10.1016/j.ijbiomac.2024.132058

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Ferritinophagy mediates adaptive resistance to EGFR tyrosine kinase inhibitors in non-small cell lung cancer

Authors: Hui Wang, Qianfan Hu, Yuzhong Chen, Xing Huang, Yipeng Feng, Yuanjian Shi, Rutao Li, Xuewen Yin, Xuming Song, Yingkuan Liang, Te Zhang, Lin Xu, Gaochao Dong, Feng Jiang

Journal: Nat Commun

PubMed ID: 38760351

Doi: 10.1038/s41467-024-48433-8

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