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Efficient preparation of high-purity and intact mesenchymal stem cell-derived extracellular vesicles

Authors: Fangfang Ni, Qingfu Zhu, Hengrui Li, Fei Liu, Hao Chen

Journal: Anal Bioanal Chem

PubMed ID: 38355844

Doi: 10.1007/s00216-024-05193-0

Products & Services: Proteins, Expression, Isolation and Analysis

Measurement of neuropeptide Y with molecularly imprinted polypyrrole on carbon fiber microelectrodes

Authors: Luis López, Kelly Lozano, John Cruz, Krystal Flores, Lauren Fernández-Vega, Lisandro Cunci

Journal: Neuropeptides

PubMed ID: 38335798

Doi: 10.1016/j.npep.2024.102413

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Single dose of a recombinant vesicular stomatitis virus-based vaccine elicits robust and durable neutralizing antibody response against Hantaan virus

Authors: Hui Zhang, He Liu , Jing Wei , Yamei Dang , Yuan Wang , Qiqi Yang , Liang Zhang , Chuantao Ye , Bin Wang , Xiaolei Jin , Linfeng Cheng , Hongwei Ma , Yangchao Dong , Yinghui Li , Yinlan Bai , Xin Lv , Yingfeng Lei , Zhikai Xu , Wei Ye , Fanglin Zhang

Journal: NPJ Vaccines .

PubMed ID: 38341504

Doi: 10.1038/s41541-024-00814-2

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An Enzyme-Cleavable Solubilizing-Tag Facilitates the Chemical Synthesis of Mirror-Image Protein

Authors: Yupeng Zheng, Baochang Zhang , Wei-Wei Shi, Xiangyu Deng, Tong-Yue Wang, Dongyang Han, Yuxiang Ren, Ziyi Yang, Yong-Kang Zhou, Jian Kuang, Zhi-Wen Wang, Shan Tang, Ji-Shen Zheng

Journal: Angew Chem Int Ed Engl .

PubMed ID: 38326236

Doi: 10.1002/ange.202318897

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ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis

Authors: Yongbing Yang , Yanan Wang , Zhongcheng Wang , Huanyu Yan , Yi Gong , Yingchao Hu , Yuying Jiang , Shuang Wen , Feifei Xu , Bingwei Wang , Fiachra Humphries , Yun Chen , Xi Wang , Shuo Yang

Journal: Nat Cell Biol .

PubMed ID: 38326554

Doi: 10.1038/s41556-024-01351-9

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Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8

Authors: Shan Jiang , Xi Lin , Lijie Wu , Ling Wang , Yiran Wu , Ziyi Xu , Fei Xu

Journal: Sci Adv .

PubMed ID: 38306437

Doi: 10.1126/sciadv.adj7500

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HIV coinfection exacerbates HBV-induced liver fibrogenesis through a HIF-1α- and TGF-β1-dependent pathway

Authors: Min Xu , Charlotte Warner, Xiaoqiong Duan, Zhimeng Cheng, Andre J Jeyarajan, Wenting Li, Yongtao Wang , Tuo Shao , Shadi Salloum , Pei-Jer Chen , Xu Yu , Raymond T Chung , Wenyu Lin

Journal: J Hepatol

PubMed ID: 38311121

Doi: 10.1016/j.jhep.2024.01.026

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A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

Authors: Marian Hruska-Plochan, Vera I Wiersma, Katharina M Betz, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma , Laura De Vos, Karl Frontzek , Adriano Aguzzi, Tammaryn Lashley , Mark D Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann 4, Magdalini Polymenidou 13

Journal: Nature

PubMed ID: 38355792

Doi: 10.1038/s41586-024-07042-7

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Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC

Authors: Anna Miścicka, Alexander G Bulakhov, Kazushige Kuroha, Alexandra Zinoviev, Christopher U T Hellen, Tatyana V Pestova

Journal: Nucleic Acids Res

PubMed ID: 38366554

Doi: 10.1093/nar/gkae087

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Molecular mechanism of human ISG20L2 for the ITS1 clea vag e in the processing of 18S precursor ribosomal RNA

Authors: Yinliang Ma, Jiaxu Wang, Xingyi He, Yuhang Liu, Shuo Zhen, Lina An, Qian Yang, Fumin Niu, Hong Wang, Boran An, Xinyue Tai, Zhenzhen Yan, Chen Wu, Xiaoyun Yang, Xiuhua Liu

Journal: Nucleic Acids Res

PubMed ID: 38153123

Doi: 10.1093/nar/gkad1210

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Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel Na18 with a Unique Mechanism of Action

Authors: John M Gilchrist, Nien-Du Yang, Victoria Jiang, Bryan D Moyer

Journal: Mol Pharmacol

PubMed ID: 38195157

Doi: 10.1124/molpharm.123.000789

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The ETI-dependent receptor-like kinase 1 positively regulates effector-triggered immunity by stabilizing NLR-required for cell death 4 in Nicotiana benthamiana

Authors: Yujing Sun, Fan Liu, Mengzhu Zeng, Xinjie Zhang, Ying Cui, Zhaodan Chen, Lei Wang, Yuanpeng Xu, Jinbin Wu, Shengya Guo, Xian Dong, Suomeng Dong, Yan Wang, Yuanchao Wang

Journal: New Phytol

PubMed ID: 38362937

Doi: 10.1111/nph.19596

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Safety and immunogenicity of CoronaVac in healthy adults: A prospective observational multicenter real-world study in Henan Province, China

Authors: Benchen Rao, Ling Wang, Mengzhao Yang, Hong Luo, Junyi Sun, Shanshuo Liu, Haiyu Wang, Xuemei Wang, Lei Li, Chengyu Yuan, Zujiang Yu, Zhigang Ren

Journal: Virulence

PubMed ID: 38326274

Doi: 10.1080/21505594.2024.2310450

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Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

Authors: Wonjae Sung, Min-Young Noh, Minyeop Nahm, Yong Sung Kim, Chang-Seok Ki, Young-Eun Kim, Hee-Jin Kim, Seung Hyun Kim

Journal: J Neuroinflammation

PubMed ID: 38347588

Doi: 10.1186/s12974-024-03039-1

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Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction

Authors: Dingyi Wang, Changyang Xing, Yuan Liang, Chen Wang, Ping Zhao, Xiao Liang, Qiuyang Li, Lijun Yuan

Journal: Adv Mater

PubMed ID: 38270289

Doi: 10.1002/adma.202310421

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Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1

Authors: Courtney J Mycroft-West, Sahar Abdelkarim, Helen M E Duyvesteyn, Neha S Gandhi, Mark A Skidmore, Raymond J Owens, Liang Wu

Journal: Nat Commun

PubMed ID: 38351061

Doi: 10.1038/s41467-024-45419-4

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Unveiling the Dynamic Self-Assembly of a Recombinant Dragline-Silk-Mimicking Protein

Authors: Dongqing Wu, Anamaria Koscic, Sonja Schneider, Romeo C A Dubini, Diana C Rodriguez Camargo, Sabine Schneider, Petra Rovó

Journal: Biomacromolecules

PubMed ID: 38343096

Doi: 10.1021/acs.biomac.3c01239

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Characterization of cleavage patterns and assembly of N-terminally modified GII6 norovirus VP1 proteins

Authors: Jie Ma, Jinjin Liu, Yuqi Huo

Journal: Arch Virol

PubMed ID: 38386207

Doi: 10.1007/s00705-024-05973-0

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The Role of Hyaluronan/Receptor for Hyaluronan-Mediated Motility Interactions in the Modulation of Macrophage Polarization and Cartilage Repair

Authors: Emilia Bianchini, Yun Jin Ashley Sin, You Jin Lee, Charles Lin, Utkarsh Anil, Cassie Hamill, Mary K Cowman, Thorsten Kirsch

Journal: Am J Pathol

PubMed ID: 38403161

Doi: 10.1016/j.ajpath.2024.01.020

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Erdr1 Drives Macrophage Programming via Dynamic Interplay with YAP1 and Mid1

Authors:

Journal: Immunohorizons

PubMed ID: 38392560

Doi: 10.4049/immunohorizons.2400004

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Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation

Authors: Jingyue Yu, Jinyu Hu, Margaret Baldini, Huan Lei, Lei Li, Shanshan Luo, Jielian Wu, Xupin Liu, Dan Shan, Yanfei Xie, Haihong Fang, Jun Yu

Journal: J Nat Med

PubMed ID: 38409483

Doi: 10.1007/s11418-023-01776-w

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Inhibition of AMPK activation in sensu stricto limits the parasite's glucose metabolism and survival

Authors: Mingzhi Yan, Hui Liu, Yansen Su, Xiaojuan Bi, Ning Yang, Renyong Lin, Guodong Lü

Journal: Antimicrob Agents Chemother

PubMed ID: 38349157

Doi: 10.1128/aac.01202-23

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Filamin A Is a Prognostic Serum Biomarker for Differentiating Benign Prostatic Hyperplasia from Prostate Cancer in Caucasian and African American Men

Authors: Nischal Mahaveer Chand, Poornima K Tekumalla, Matt T Rosenberg, Albert Dobi, Amina Ali, Gregory M Miller, Juan J Aristizabal-Henao, Elder Granger, Stephen J Freedland, Mark D Kellogg, Shiv Srivastava, David G McLeod, Niven R Narain, Michael A Kiebish

Journal: Cancers (Basel)

PubMed ID: 38398103

Doi: 10.3390/cancers16040712

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Newcastle disease virus regulates its replication by instigating oxidative stress-driven Sirtuin 7 production

Authors: Kamal Shokeen, Sachin Kumar

Journal: J Gen Virol

PubMed ID: 38376490

Doi: 10.1099/jgv.0.001961

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Structure of the p53 degradation complex from HPV16

Authors: John C K Wang, Hannah T Baddock, Amirhossein Mafi, Ian T Foe, Matthew Bratkowski, Ting-Yu Lin, Zena D Jensvold, Magdalena Preciado López, David Stokoe, Dan Eaton, Qi Hao, Aaron H Nile

Journal: Nat Commun

PubMed ID: 38418456

Doi: 10.1038/s41467-024-45920-w

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SOX9 Induces Orbital Fibroblast Activation in Thyroid Eye Disease Via MAPK/ERK1/2 Pathway

Authors: Min Zhou, Bingying Lin, Pengsen Wu, Yu Ke, Siyu Huang, Fan Zhang, Xiangqing Hei, Zhen Mao, Xingyi Li, Pengxia Wan, Tingting Chen, Huasheng Yang, Danping Huang

Journal: Invest Ophthalmol Vis Sci

PubMed ID: 38345552

Doi: 10.1167/iovs.65.2.25

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The Humanization and Maturation of an Anti-PrPc Antibody

Authors: Cheng Zhang, Fanlei Ran, Lei Du, Xiaohui Wang, Lei Liu, Jinming Liu, Quan Chen, Yang Cao, Lijun Bi, Haiying Hang

Journal: Bioengineering (Basel)

PubMed ID: 38534516

Doi: 10.3390/bioengineering11030242

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Preorganized cyclic modules facilitate the self-assembly of protein nanostructures

Authors: Jaka Snoj, Fabio Lapenta, Roman Jerala

Journal: Chem Sci

PubMed ID: 38455016

Doi: 10.1039/d3sc06658d

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Development of a live-attenuated chimeric vaccine against the emerging Usutu virus

Authors: Zheng-Jian Wang, Rong-Rong Zhang, Mei Wu, Hui Zhao, Xiao-Feng Li, Qing Ye, Cheng-Feng Qin

Journal: Vaccine

PubMed ID: 38310016

Doi: 10.1016/j.vaccine.2024.01.077

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Exploring the Impact of Primer-Template Mismatches on PCR Performance of DNA Polymerases Varying in Proofreading Activity

Authors: Ke Huang, Jilei Zhang, Jing Li, Haixiang Qiu, Lanjing Wei, Yi Yang, Chengming Wang

Journal: Genes (Basel)

PubMed ID: 38397205

Doi: 10.3390/genes15020215

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Ultrasound-mediated gene delivery specifically targets liver sinusoidal endothelial cells for sustained FVIII expression in hemophilia A mice

Authors: Savannah M Lawton, Megan A Manson, Meng-Ni Fan, Ting-Yen Chao, Chun-Yu Chen, Peter Kim, Carley Campbell, Xiaohe Cai, Amber Vander Kooi, Carol H Miao

Journal: Mol Ther

PubMed ID: 38341614

Doi: 10.1016/j.ymthe.2024.02.010

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Identification of Candidate Expansin Genes Associated with Seed Weight in Pomegranate ( L)

Authors: Chunyan Liu, Haoyu Zhao, Jiyu Li, Zhen Cao, Bo Deng, Xin Liu, Gaihua Qin

Journal: Genes (Basel)

PubMed ID: 38397202

Doi: 10.3390/genes15020212

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Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors

Authors: Kiara N Berríos, Aleksia Barka, Jasleen Gill, Juan C Serrano, Peter F Bailer, Jared B Parker, Niklaus H Evitt, Kiran S Gajula, Junwei Shi, Rahul M Kohli

Journal: Nucleic Acids Res

PubMed ID: 38261989

Doi: 10.1093/nar/gkae024

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Poly-γ-glutamylation of biomolecules

Authors: Ghader Bashiri, Esther M M Bulloch, William R Bramley, Madison Davidson, Stephanie M Stuteley, Paul G Young, Paul W R Harris, Muhammad S H Naqvi, Martin J Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N Baker, Christopher J Squire

Journal: Nat Commun

PubMed ID: 38346985

Doi: 10.1038/s41467-024-45632-1

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Cross-Phosphorylation between AgrC Histidine Kinase and the Noncognate Response Regulator Lmo1172 in under Benzalkonium Chloride Stress

Authors: Tao Yu, Xiaojie Jiang, Xiaobo Xu, Ping Xu, Shuxing Qiu, Junlei Yin, David P Hamilton, Xiaobing Jiang

Journal: Microorganisms

PubMed ID: 38399796

Doi: 10.3390/microorganisms12020392

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A quaternary ammonium-based nanosystem enables delivery of CRISPR/Cas9 for cancer therapy

Authors: Mengzhu Zhang, Siyu Sun, Xiao Liang, Zengguang Liu, Jiaxin Yin, Quanshun Li, Shengcai Yang

Journal: Biomater Sci

PubMed ID: 38240497

Doi: 10.1039/d3bm01629c

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Enhancing sensitivity of qPCR assays targeting Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae by using a mutant Taq DNA polymerase

Authors: Selin Nar Otgun, Canan Zohre Ketre Kolukirik, Nuriye Unal Sahin, Mustafa Kolukirik, Gozde Girgin Ozgumus, Meral Turan, Mert Elmas, Selcuk Kilic

Journal: J Microbiol Methods

PubMed ID: 38360298

Doi: 10.1016/j.mimet.2024.106899

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Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology

Authors: Nayara Braga Emidio , Brandi M Small , Amanda R Keller , Ross W Cheloha , Laura M Wingler

Journal: Mol Pharmacol

PubMed ID: 38164609

Doi: 10.1124/molpharm.123.000797

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DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α

Authors: Aidi Gao, Mingxia Zhang, Shuang Qi Zhu, Shitao Zou, Hengrui Chen, Xiaoqin Li, Chao He, Liangsu Zhou, Yan Mei, Weiqun Ding, Jundong Zhou, Yue Zhou, Yuandong Cao

Journal: Cell Death Dis

PubMed ID: 38402183

Doi: 10.1038/s41419-024-06552-6

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Identification and characterization of the low molecular mass ferredoxins involved in central metabolism in Heliomicrobium modesticaldum

Authors: Karim A Walters, Kevin E Redding, John H Golbeck

Journal: Photosynth Res

PubMed ID: 38306001

Doi: 10.1007/s11120-023-01069-z

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Characterization of N-glycosylation and its Functional Role in SIDT1-Mediated RNA Uptake

Authors: Tingting Yang, Haonan Xiao, Xiulan Chen, Le Zheng, Hangtian Guo, Jiaqi Wang, Xiaohong Jiang, Chen-Yu Zhang, Fuquan Yang, Xiaoyun Ji

Journal: J Biol Chem

PubMed ID: 38237680

Doi: 10.1016/j.jbc.2024.105654

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The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression

Authors: Qiankun Wang, Kolin M Clark, Ritudhwaj Tiwari, Nagarajan Raju, Gregory K Tharp, Jeffrey Rogers, R Alan Harris, Muthuswamy Raveendran, Steven E Bosinger, Tricia H Burdo, Guido Silvestri, Liang Shan

Journal: Cell

PubMed ID: 38428396

Doi: 10.1016/j.cell.2024.01.048

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Molecular dissection of an intronic enhancer governing cold-induced expression of the vacuolar invertase gene in potato

Authors: Xiaobiao Zhu , Airu Chen, Nathaniel M Butler, Zixian Zeng, Haoyang Xin , Lixia Wang , Zhaoyan Lv, Dani Eshel, David S Douches, Jiming Jiang

Journal: Cell

PubMed ID: 38374801

Doi: 10.1093/plcell/koae050

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The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Authors: Pengbiao Xu , Ying Liu , Chong Liu , Baptiste Guey , Lingyun Li , Pauline Melenec , Jonathan Ricci , Andrea Ablasser

Journal: Nature

PubMed ID: 38418882

Doi: 10.1038/s41586-024-07112-w

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Hormonal steroids induce multidrug resistance and stress response genes in Neisseria gonorrhoeae by binding to MtrR

Authors: Grace M Hooks, Julio C Ayala, Concerta L Holley, Vijaya Dhulipala, Grace A Beggs, John R Perfect, Maria A Schumacher, William M Shafer, Richard G Brennan

Journal: Nat Commun

PubMed ID: 38326294

Doi: 10.1038/s41467-024-45195-1

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Screening and characterization of aptamers recognizing the periodontal pathogen Tannerella forsythia

Authors: Danuta Mizgalska, Stanisław Malicki, Anna Golda, Barbara Chruścicka-Smaga, Jan Potempa

Journal: FEBS Open Bio

PubMed ID: 38308430

Doi: 10.1002/2211-5463.13772

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Corrigendum: Experimental validation of immunogenic SARS-CoV-2 T cell epitopes identified by artificial intelligence

Authors: Lorenzo Federico, Brandon Malone, Simen Tennøe, Viktoriia Chaban, Julie Røkke Osen, Murat Gainullin, Eva Smorodina, Hassen Kared, Rahmad Akbar, Victor Greiff, Richard Stratford, Trevor Clancy, Ludvig Andre Munthe

Journal: Front Immunol

PubMed ID: 38449865

Doi: 10.3389/fimmu.2024.1377041

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Recurrent evolutionary switches of mitochondrial cytochrome c maturation systems in Archaeplastida

Authors: Huang Li, Soujanya Akella, Carina Engstler, Joy J Omini, Moira Rodriguez, Toshihiro Obata, Chris Carrie, Heriberto Cerutti, Jeffrey P Mower

Journal: Nat Commun

PubMed ID: 38378784

Doi: 10.1038/s41467-024-45813-y

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Human sequences form R-loop structures

Authors: Agata M Parsons, Kemin Su, Maya Daniels, Gerrit J Bouma, Gregory B Vanden Heuvel, Erik D Larson

Journal: MicroPubl Biol

PubMed ID: 38371318

Doi: 10.17912/micropub.biology.001058

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Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes

Authors: Filip Mihalič, Dahiana Arcila, Mats E Pettersson, Pouria Farkhondehkish, Eva Andersson, Leif Andersson, Ricardo Betancur-R, Per Jemth

Journal: Mol Biol Evol

PubMed ID: 38301272

Doi: 10.1093/molbev/msae018

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Tandem repeats of highly bioluminescent NanoLuc are refolded noncanonically by the Hsp70 machinery

Authors: Dimitra Apostolidou, Pan Zhang, Devanshi Pandya, Kaden Bock, Qinglian Liu, Weitao Yang, Piotr E Marszalek

Journal: Protein Sci

PubMed ID: 38284490

Doi: 10.1002/pro.4895

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Chagasin from Trypanosoma cruzi as a molecular scaffold to express epitopes of TSA-1 as soluble recombinant chimeras

Authors: Rosa Elena Cárdenas-Guerra, Octavio Montes-Flores, Edgar Ezequiel Nava-Pintor, Gerardo Reséndiz-Cardiel, Claudia Ivonne Flores-Pucheta, Yasmín Irene Rodríguez-Gavaldón, Rossana Arroyo, Maria Elena Bottazzi, Peter J Hotez, Jaime Ortega-López

Journal: Protein Expr Purif

PubMed ID: 38423156

Doi: 10.1016/j.pep.2024.106458

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Systematic Engineering of for Efficient Production of Cytidine 5'-Monophosphate

Authors: Min Zhou, Liyuan Wei, Chongzhi Wu, Wei Chen, Zhengju Tang

Journal: ACS Omega

PubMed ID: 38371780

Doi: 10.1021/acsomega.3c07713

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Supramolecular Synthons in Protein-Ligand Frameworks

Authors: Ronan J Flood, Niamh M Mockler, Aurélien Thureau, Maura Malinska, Peter B Crowley

Journal: Cryst Growth Des

PubMed ID: 38463617

Doi: 10.1021/acs.cgd.3c01480

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Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

Authors: Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Christine J F Nielsen, Marco Mele, Katrine R Hauerslev, Helene L Pedersen, Eva Balling, Pernille Vahl, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer

Journal: Br J Cancer

PubMed ID: 38310186

Doi: 10.1038/s41416-024-02591-0

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A mutational atlas for Parkin proteostasis

Authors: Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer E Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: Nat Commun

PubMed ID: 38378758

Doi: 10.1038/s41467-024-45829-4

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Constitutive activation mechanism of a class C GPCR

Authors: Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V Robinson, Jaekyung Hyun, Vsevolod Katritch, Kwang Pyo Kim, Yunje Cho

Journal: Nat Struct Mol Biol

PubMed ID: 38332368

Doi: 10.1038/s41594-024-01224-7

Products & Services: Proteins, Expression, Isolation and Analysis

Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection

Authors: Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres

Journal: RSC Med Chem

PubMed ID: 38665834

Doi: 10.1039/d3md00724c

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Cystatin from the helminth upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

Authors: Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R Williams, Luis Caraballo

Journal: Front Immunol

PubMed ID: 38481989

Doi: 10.3389/fimmu.2024.1328401

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Corrigendum: Enhanced immunogenicity and protective efficacy in mice following a Zika DNA vaccine designed by modulation of membrane-anchoring regions and its association to adjuvants

Authors: Franciane Mouradian Emidio Teixeira, Luana de Mendonça Oliveira, Anna Cláudia Calvielli Castelo Branco, Ricardo Wesley Alberca, Emanuella Sarmento Alho de Sousa, Bruno Henrique de Sousa Leite, Wenny Camilla Dos Santos Adan, Alberto José da Silva Duarte, Roberto Dias Lins, Maria Notomi Sato, Isabelle Freire Tabosa Viana

Journal: Front Immunol

PubMed ID: 38361947

Doi: 10.3389/fimmu.2024.1376059

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UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment

Authors: Yin Li, Manling Jiang, Ling Aye, Li Luo, Yong Zhang, Fengkai Xu, Yongqi Wei, Dan Peng, Xiang He, Jie Gu, Xiaofang Yu, Guoping Li, Di Ge, Chunlai Lu

Journal: Nat Commun .

PubMed ID: 38331898

Doi: 10.1038/s41467-024-45340-w

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Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery

Authors: Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, Can Wang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, Zhigang Hu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, Zhaoyu Liu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen

Journal: Nat Commun .

PubMed ID: 38378731

Doi: 10.1038/s41467-024-45690-5

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Insertion of a FLAG-tag sequence at the end of exon 9 of the TBX5 gene in three induced pluripotent stem cell lines (DHMi004-A-4, DHMi004-A-5, DHMi004-A-6) by CRISPR/Cas9 technology

Authors: Harald Lahm, Niraj K Singh, Irina Gottmann, Stefanie A Doppler, Elda Dzilic, Heike Preisler, Stephanie Schneider, Rüdiger Lange, Markus Krane, Martina Dreßen

Journal: Cell Research

PubMed ID: 38100916

Doi: 10.1016/j.scr.2023.103261

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Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore

Authors: Yasmeen J Solano , Michael P Everett , Kelly S Dang , Jude Abueg , Philip D Kiser

Journal: Nature Chemical Biology

PubMed ID: 38355721

Doi: 10.1038/s41589-024-01554-z

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Unraveling the Catalytic Mechanism of Taxadiene-5α-hydroxylase from Crystallography and Computational Analyses

Authors: Xitong Song, Qian Wang, Xiaoxi Zhu, Wenhan Fang, Xiaonan Liu, Chao Shi, Zhenzhan Chang, Huifeng Jiang, and Binju Wang

Journal: ACS Catal

Doi: doi.org/10.1021/acscatal.3c05807

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Neuroprotective effects of annexin A1 tripeptide in rats with sepsis-associated encephalopathy

Authors: Qiao Cui, Nannan Qin, Yonghan Zhang, Yanmei Miao, Leiyu Xie, Xinglong Ma, Zhiquan Zhang, Peng Xie

Journal: Biotechnol Appl Biochem

PubMed ID: 38409880

Doi: 10.1002/bab.2569

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Visualizing the impact of disease-associated mutations on G protein-nucleotide interactions

Authors: Kara Anazia, Lucien Koenekoop, Guillaume Ferré, Enzo Petracco, Hugo Gutiérrez-de-Teran, Matthew T Eddy

Journal: biorxiv

PubMed ID: 38352316

Doi: 10.1101/2024.01.30.578006

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Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis

Authors: Ji Geng, Shuangxi Li, Yu Li, Zhihao Wu, Sunil Bhurtel, Suman Rimal, Danish Khan, Rani Ohja, Onn Brandman, Bingwei Lu

Journal: Nat Commun

PubMed ID: 38388640

Doi: 10.1038/s41467-024-45525-3

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Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides

Authors: Olga Rechkoblit, Daniela Sciaky, Dale F Kreitler, Angeliki Buku, Jithesh Kottur, Aneel K Aggarwal

Journal: Nat Struct Mol Biol

PubMed ID: 38321146

Doi: 10.1038/s41594-024-01220-x

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The exposure to glyphosate on the integrity of intestinal epithelial tight junctions of chicks

Authors: Mohamed A Fathi, Dan Shen, Lu Luo, Yansen Li, Shaaban S Elnesr, Chunmei Li

Journal: J Environ Sci Health B

PubMed ID: 38400726

Doi: 10.1080/03601234.2024.2319006

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Gene-edited triple mutant Medicago plants do not flower

Authors: Axel Poulet, Min Zhao, Yongyan Peng, FangFei Tham, Mauren Jaudal, Lulu Zhang, Josien C van Wolfswinkel, Joanna Putterill

Journal: Front Plant Sci

PubMed ID: 38469328

Doi: 10.3389/fpls.2024.1357924

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Effects of polyphenol and gelatin types on the physicochemical properties and emulsion stabilization of polyphenol-crosslinked gelatin conjugates

Authors: Wenjuan Wu, Cuiping Shi, Ye Zi, Huan Gong, Lijia Chen, Guangyi Kan, Xichang Wang, Jian Zhong

Journal: Food Chem X

PubMed ID: 38440057

Doi: 10.1016/j.fochx.2024.101250

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A Modified Tridecapeptide Probe for Imaging Cell Junction

Authors: Jingrui Li, Yuhan Wu, Chunyu Liu, Shu Zhang, Xin Su, Songbo Xie, Fengtang Yang

Journal: Molecules

PubMed ID: 38474514

Doi: 10.3390/molecules29051003

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Structure of the WYL-domain containing transcription activator, DriD, in complex with ssDNA effector and DNA target site

Authors: Maria A Schumacher, Emily Cannistraci, Raul Salinas, Devin Lloyd, Ella Messner, Kevin Gozzi

Journal: Nucleic Acids Res

PubMed ID: 38142455

Doi: 10.1093/nar/gkad1198

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A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort

Authors: Oscar Alcazar, Sung-Ting Chuang, Gang Ren, Mitsunori Ogihara, Bobbie-Jo M Webb-Robertson, Ernesto S Nakayasu, Peter Buchwald, Midhat H Abdulreda

Journal: biorxiv

PubMed ID: 38405796

Doi: 10.1101/2024.02.09.579673

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Metabolic engineering of Synechocystis sp PCC 6803 for the improved production of phenylpropanoids

Authors: Kateryna Kukil, Pia Lindberg

Journal: Microb Cell Fact

PubMed ID: 38369470

Doi: 10.1186/s12934-024-02330-3

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Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from

Authors: Davide Doni, Eva Cavallari, Martin Ezequiel Noguera, Hernan Gustavo Gentili, Federica Cavion, Gustavo Parisi, Maria Silvina Fornasari, Geppo Sartori, Javier Santos, Massimo Bellanda, Donatella Carbonera, Paola Costantini, Marco Bortolus

Journal: Int J Mol Sci

PubMed ID: 38339189

Doi: 10.3390/ijms25031912

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FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway

Authors: Zhenyu Hu, Jindan Dai, Tianpeng Xu, Hui Chen, Guoxiu Shen, Jie Zhou, Hongfang Ma, Yang Wang, Litai Jin

Journal: Respir Res

PubMed ID: 38419044

Doi: 10.1186/s12931-024-02733-1

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EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation

Authors: Yuanyuan Ji, Maryam Izadi-Seitz, Annemarie Landmann, Lukas Schwintzer, Britta Qualmann, Michael M Kessels

Journal: J Neurosci

PubMed ID: 38129132

Doi: 10.1523/JNEUROSCI.0236-23.2023

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Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication

Authors: Qian Du, Lei Zhu, Jianhui Zhong, Xueqi Wei, Qi Zhang, Tengfei Shi, Cong Han, Xinhuan Yin, Xingqi Chen, Dewen Tong, Yong Huang

Journal: PLoS Pathog

PubMed ID: 38394330

Doi: 10.1371/journal.ppat.1012014

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Determinants of viscoelasticity and flow activation energy in biomolecular condensates

Authors: Ibraheem Alshareedah , Anurag Singh , Sean Yang , Vysakh Ramachandran , Alexander Quinn , Davit A Potoyan , Priya R Banerjee

Journal: SCIENCE ADVANCES

PubMed ID: 38363841

Doi: 10.1126/sciadv.adi6539

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Covalent bicyclization of protein complexes yields durable quaternary structures

Authors: George H Hutchins, Sebastian Kiehstaller, Pascal Poc, Abigail H Lewis, Jisun Oh, Raya Sadighi, Nicholas M Pearce, Mohamed Ibrahim, Ivana Drienovská, Anouk M Rijs, Saskia Neubacher, Sven Hennig, Tom N Grossmann

Journal: Chem

PubMed ID: 38344167

Doi: 10.1016/j.chempr.2023.10.003

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Seed-specific expression of porcine verotoxigenic Escherichia coli antigens in tobacco plants as a potential model of edible vaccines

Authors: Serena Reggi, Matteo Dell'Anno, Antonella Baldi, Luciana Rossi

Journal: Vet Res Commun

PubMed ID: 38319502

Doi: 10.1007/s11259-024-10318-y

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Designed modular protein hydrogels for biofabrication

Authors: Dalia Dranseike, Yusuke Ota, Thomas G W Edwardson, Elia A Guzzi, Mao Hori, Zrinka Raguz Nakic, Dhananjay V Deshmukh, Mikail D Levasseur, Kevin Mattli, Christina M Tringides, Jiangtao Zhou, Donald Hilvert, Christin Peters, Mark W Tibbitt

Journal: Acta Biomater

PubMed ID: 38382830

Doi: 10.1016/j.actbio.2024.02.019

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Epigenetic disruption of histone deacetylase-2 accelerated apoptotic signaling and retarded malignancy in gastric cells

Authors: Sayedeh Azimeh Hosseini, Mahdi Ghatrehsamani, Hajar Yaghoobi, Fatemeh Elahian, Seyed Abbas Mirzaei

Journal: Epigenomics

PubMed ID: 38356395

Doi: 10.2217/epi-2023-0350

A mRNA Vaccine for Crimean-Congo Hemorrhagic Fever Virus Expressing Non-Fusion GnGc Using NSm Linker Elicits Unexpected Immune Responses in Mice

Authors: Tong Chen, Zhe Ding, Xuejie Li, Yingwen Li, Jiaming Lan, Gary Wong

Journal: Viruses

PubMed ID: 38543744

Doi: 10.3390/v16030378

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Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders

Authors: Nate Shepard, David Baez-Nieto, Sumaiya Iqbal, Erkin Kurganov, Nikita Budnik, Arthur J Campbell, Jen Q Pan, Morgan Sheng, Zohreh Farsi

Journal: Sci Rep

PubMed ID: 38307912

Doi: 10.1038/s41598-024-53102-3

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CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin

Authors: Rong Li, Junyi Wang, Zhenfan Xie, Xinyu Tian, Jie Hou, Dongli Wang, Hui Qian, Han Shen, Wenrong Xu

Journal: Oncogene

PubMed ID: 38366146

Doi: 10.1038/s41388-024-02968-8

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PeptiVAX: A new adaptable peptides-delivery platform for development of CTL-based, SARS-CoV-2 vaccines

Authors: Sara Feola, Jacopo Chiaro, Manlio Fusciello, Salvatore Russo, Iivari Kleino, Leena Ylösmäki, Eliisa Kekäläinen, Johanna Hästbacka, Pirkka T Pekkarinen, Erkko Ylösmäki, Stefania Capone, Antonella Folgori, Angelo Raggioli, Carolina Boni, Camilla Tiezzi, Andrea Vecchi, Monica Gelzo, Hassen Kared, Alessandra Nardin, Michael Fehlings, Veronique Barban, Petra Ahokas, Tapani Viitala, Giuseppe Castaldo, Lucio Pastore, Paul Porter, Sari Pesonen, Vincenzo Cerullo

Journal: Int J Biol Macromol

PubMed ID: 38331062

Doi: 10.1016/j.ijbiomac.2024.129926

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Photoactivatable CRISPR/Cas12a Sensors for Biomarkers Imaging and Point-of-Care Diagnostics

Authors: Qing-Nan Li, Dong-Xia Wang, Dan-Ye Chen, Jia-Ao Lyu, Ya-Xin Wang, Shun-Li Wu, Hong-Xin Jiang, De-Ming Kong

Journal: Anal Chem

PubMed ID: 38305871

Doi: 10.1021/acs.analchem.3c05497

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Role of aminopeptidase N-like in the acquisition of begomoviruses by Bemisia tabaci, the whitefly vector

Authors: Yun-Yun Fan, Yao Chi, Na Chen, Wilmer J Cuellar, Xiao-Wei Wang

Journal: Insect Sci

PubMed ID: 38369384

Doi: 10.1111/1744-7917.13336

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In vitro evolution of diagnostic antibodies targeting native antigens in plasma by sandwich flow cytometry

Authors: Mingxia Liang, Fanlei Ran, Li Li, Haiying Hang, Lili An

Journal: Biotechnol J

PubMed ID: 38403438

Doi: 10.1002/biot.202300492

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Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia

Authors: Xiaoqi Wang, Yuanjie Hao, Yujie Yin, Yunlong Hou, Ningxin Han, Yi Liu, Zhen Li, Yaru Wei, Kun Ma, Jiaojiao Gu, Yan Ma, Hui Qi, Zhenhua Jia

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 38343495

Doi: 10.2147/COPD.S436323

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A SARS-CoV-2 RBD vaccine fused to the chemokine MIP-3α elicits sustained murine antibody responses over 12 months and enhanced lung T-cell responses

Authors: James Tristan Gordy, Yinan Hui, Courtney Schill, Tianyin Wang, Fengyixin Chen, Kaitlyn Fessler, Jacob Meza, Yangchen Li, Alannah D Taylor, Rowan E Bates, Petros C Karakousis, Andrew Pekosz, Jaiprasath Sachithanandham, Maggie Li, Styliani Karanika, Richard B Markham

Journal: Front Immunol

PubMed ID: 38370404

Doi: 10.3389/fimmu.2024.1292059

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SPOP point mutations regulate substrate preference and affect its function

Authors: Yanran Deng, Wenhao Ding, Kaize Ma, Meixiao Zhan, Li Sun, Zizhang Zhou, Ligong Lu

Journal: Cell Death Dis

PubMed ID: 38409107

Doi: 10.1038/s41419-024-06565-1

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Efficient bio-remediation of multiple aromatic hydrocarbons using different types of thermotolerant, ring-cleaving dioxygenases derived from Aeribacillus pallidus HB-1

Authors: Mingchang Li, Lu Cao, Dakun Liu, Tianqi Su, Wei Cheng, Guoqiang Li, Ting Ma

Journal: Bioresour Technol

PubMed ID: 38387841

Doi: 10.1016/j.biortech.2024.130472

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Cell-Penetrating and Enzyme-Responsive Peptides for Targeted Cancer Therapy: Role of Arginine Residue Length on Cell Penetration and In Vivo Systemic Toxicity

Authors: Behnaz Ghaemi, Swati Tanwar, Aruna Singh, Dian R Arifin, Michael T McMahon, Ishan Barman, Jeff W M Bulte

Journal: ACS Appl Mater Interfaces

PubMed ID: 38385360

Doi: 10.1021/acsami.3c14908

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Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

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Disordered regions mediate the interaction of p53 and MRE11

Authors: Sinem Usluer , Markus Galhuber , Yukti Khanna , Benjamin Bourgeois , Emil Spreitzer , Helene Michenthaler, Andreas Prokesch, Tobias Madl

Journal: Cell Research

PubMed ID: 38123020

Doi: 10.1016/j.bbamcr.2023.119654

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Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

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