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Nitrogen-Doped Carbon Dots Facilitate CRISPR/Cas for Reducing Antibiotic Resistance Genes in the Environment

Authors: Feiran Chen, Hao Du, Mengna Tao, Lanqing Xu, Chuanxi Wang, Jason C White, Zhenyu Wang, Baoshan Xing

Journal: J Agric Food Chem

PubMed ID: 38335532

Doi: 10.1021/acs.jafc.3c08558

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Lymph Node-Targeted Vaccine Boosting of TCR T-cell Therapy Enhances Antitumor Function and Eradicates Solid Tumors

Authors: Dylan J Drakes, Abdulraouf M Abbas, Jacqueline Shields, Martin P Steinbuck, Aniela Jakubowski, Lochana M Seenappa, Christopher M Haqq, Peter C DeMuth

Journal: Cancer Immunol Res

PubMed ID: 38270373

Doi: 10.1158/2326-6066.CIR-22-0978

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Primary vulvar adenocarcinoma of intestinal type: Report of two cases showing molecular similarity with colorectal adenocarcinoma

Authors: Claudia Mateoiu, Andrea Palicelli, Thais Maloberti, Dario De Biase, Antonio De Leo, Magnus Lindh, Katja Stenström Bohlin, Simona Stolnicu

Journal: Pathol Res Pract

PubMed ID: 38340583

Doi: 10.1016/j.prp.2024.155181

Products & Services: Molecular Biology Reagents

An Insertion Within SIRPβ1 Shows a Dual Effect Over Alzheimer’s Disease Cognitive Decline Altering the Microglial Response

Authors: José María García-Alberca, Itziar de Rojas, Elisabeth Sanchez-Mejias , Diego Garrido-Martín

Journal: JOURNAL OF ALZHEIMERS DISEASE

PubMed ID: 38427484

Doi: 10.3233/JAD-231150

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MFSD7c functions as a transporter of choline at the blood–brain barrier

Authors: Xuan Thi Anh Nguyen, Thanh Nha Uyen Le, Toan Q. Nguyen, Hoa Thi Thuy Ha, Anna Artati, Nancy C. P. Leong, Dat T. Nguyen, Pei Yen Lim, Adelia Vicanatalita Susanto, Qianhui Huang, Ling Fam, Lo Ngah Leong, Isabelle Bonne, Angela Lee, Jorge L. Granadillo, Catherine Gooch, Dejie Yu, Hua Huang, Tuck Wah Soong, Matthew Wook Chang, Markus R. Wenk, Jerzy Adamski, Amaury Cazenave-Gassiot & Long N. Nguyen

Journal: Cell Research

PubMed ID: 38302740

Doi: 10.1038/s41422-023-00923-y

Products & Services: Plasmid DNA Preparation

hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50

Authors: Vasty Osei-Amponsa, Monika Chandravanshi, Xiuxiu Lu , Valentin Magidson, Sudipto Das, Thorkell Andresson, Marzena Dyba, Venkata R Sabbasani, Rolf E Swenson, Caroline Fromont, Biraj Shrestha, Yongmei Zhao, Michelle E Clapp, Raj Chari, Kylie J Walters

Journal: Cell

PubMed ID: 38151017

Doi: 10.1016/j.molcel.2023.11.035

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Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries

Authors: Yu-Xi Tsai, Ning-En Chang, Klaus Reuter, Hao-Ting Chang, Tzu-Jing Yang, Sören von Bülow, Vidhi Sehrawat, Noémie Zerrouki, Matthieu Tuffery, Michae Gecht, Isabell Louise Grothaus, Lucio Colombi Ciacchi, Yong-Sheng Wang, Min-Feng Hsu, Kay-Hooi Khoo, Gerhard Hummer, Shang-Te Danny Hsu, Cyril Hanus , Mateusz Sikora

Journal: Cell

PubMed ID: 38428397

Doi: 10.1016/j.cell.2024.01.034

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Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase

Authors: Julia Lederhofer, Yaroslav Tsybovsky, Lam Nguyen, Julie E Raab, Adrian Creanga, Tyler Stephens, Rebecca A Gillespie, Hubza Z Syeda, Brian E Fisher, Michelle Skertic , Christina Yap, Andrew J Schaub, Reda Rawi, Peter D Kwong, Barney S Graham, Adrian B McDermott , Sarah F Andrews , Neil P King , Masaru Kanekiyo

Journal: Immunity

PubMed ID: 38430907

Doi: 10.1016/j.immuni.2024.02.003

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PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport

Authors: Paraskevi Tziortzouda , Jolien Steyaert , Wendy Scheveneels , Adria Sicart , Katarina Stoklund Dittlau , Adriana Margarida Barbosa Correia , Thibaut Burg , Arun Pal , Andreas Hermann , Philip Van Damme , Thomas G Moens , Ludo Van Den Bosch

Journal: Acta Neuropathol

PubMed ID: 38363426

Doi: 10.1007/s00401-024-02689-y

Products & Services: Peptide Synthesis

ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial

Authors: Lucia Laugwitz, Fubo Cheng, Stephan C Collins, Alexander Hustinx, Nicolas Navarro, Simon Welsch, Helen Cox, Tzung-Chien Hsieh, Aswinkumar Vijayananth, Rebecca Buchert, Benjamin Bender, Stephanie Efthymiou, David Murphy, Faisal Zafar, Nuzhat Rana, Ute Grasshoff, Ruth J Falb, Mona Grimmel, Annette Seibt, Wenxu Zheng, Hamid Ghaedi, Marie Thirion, Sébastien Couette, Reza Azizimalamiri, Saeid Sadeghian, Hamid Galehdari, Mina Zamani, Jawaher Zeighami, Alireza Sedaghat, Samira Molaei Ramshe, Ali Zare, Behnam Alipoor, Dirk Klee,

Journal: Brain

PubMed ID: 38386308

Doi: 10.1093/brain/awae058

Products & Services: PCR Cloning and Subcloning

Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

Authors: Carla A Jaeger-Ruckstuhl Yun Lo, Elena Fulton , Olivia G Waltner, Tamer B Shabaneh , Sylvain Simon , Pranav V Muthuraman , Colin E Correnti , Oliver J Newsom , Ian A Engstrom , Sami B Kanaan , Shruti S Bhise , Jobelle M C Peralta , Raymond Ruff , Jason P Price , Sylvia M Stull , Andrew R Stevens , Grace Bugos, Mitchell G Kluesner , Valentin Voillet, Vishaka Muhunthan, Fionnuala Morrish, James M Olson , Raphaël Gottado , Jay F Sarthy, Steven Henikoff , Lucas B Sullivan, Scott N Furlan, Stanley R Riddell

Journal: Immunity

PubMed ID: 38354704

Doi: 10.1016/j.immuni.2024.01.011

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Local structural preferences in shaping tau amyloid polymorphism

Authors: Nikolaos Louros , Martin Wilkinson , Grigoria Tsaka , Meine Ramakers , Chiara Morelli , Teresa Garcia , Rodrigo Gallardo , Sam D'Haeyer , Vera Goossens , Dominique Audenaert , Dietmar Rudolf Thal , Ian R Mackenzie , Rosa Rademakers , Neil A Ranson , Sheena E Radford , Frederic Rousseau , Joost Schymkowitz

Journal: Nat Commun

PubMed ID: 38310108

Doi: 10.1038/s41467-024-45429-2

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Identification of closely related species in through Analysis of Whole-Genome

Authors: Guihong Qi, Lijun Hao, Yutong Gan, Tianyi Xin, Qian Lou, Wenjie Xu, Jingyuan Song

Journal: Front Microbiol

PubMed ID: 38450170

Doi: 10.3389/fmicb.2024.1323572

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Antiviral activity of immunosuppressors alone and in combination against human adenovirus and cytomegalovirus

Authors: Marta Carretero-Ledesma, Manuela Aguilar-Guisado, Judith Berastegui-Cabrera, María Balsera-Manzanero, Jerónimo Pachón, Elisa Cordero, Javier Sánchez-Céspedes

Journal: Int J Antimicrob Agents

PubMed ID: 38401774

Doi: 10.1016/j.ijantimicag.2024.107116

Products & Services: PCR Cloning and Subcloning

A phenylalanine-free recombinant nutritional protein for the dietary management of phenylketonuria

Authors: Yvonne Mücke, Natalia Jablonka, Nicole Rimann, Hiu Man Grisch-Chan, Bernhard Hoffmann, Stefan Schillberg, Beat Thöny, Stefan Rasche

Journal: J Inherit Metab Dis

PubMed ID: 38390655

Doi: 10.1002/jimd.12719

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Authors: Chenwei Wang, Jiewen Chen, Jingyao Li, Zhihong Xu, Lihong Huang, Qian Zhao, Lei Chen, Xiaolong Liang, Hai Hu, Gang Li, Chengjie Xiong, Bin Wu, Hua You, Danyi Du, Xiaoling Wang, Hongle Li, Zibing Wang, Lin Chen

Journal: J Clin Invest

PubMed ID: 38412034

Doi: 10.1172/JCI172092

Products & Services: Molecular Biology Reagents

The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma

Authors: Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Klaus Schulze-Osthoff, Markus Templin, Nisar P Malek, Antti Poso, Michael Bitzer

Journal: Nat Commun

PubMed ID: 38346946

Doi: 10.1038/s41467-024-45247-6

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Molecular Characterization of Plant Volatile Compound Interactions with Odorant-Binding Proteins

Authors: Qi Qian, Xin Guo, Lingjie Wu, Jiarong Cui, Huiying Gao, Yajun Yang, Hongxing Xu, Zhongxian Lu, Pingyang Zhu

Journal: Plants (Basel)

PubMed ID: 38498446

Doi: 10.3390/plants13040479

Products & Services: Proteins, Expression, Isolation and Analysis

Cytokine responses to major human Cytomegalovirus antigens in mouse model

Authors: Sahar Essa, Hussain A Safar, Raj Raghupathy

Journal: Cytokine

PubMed ID: 38359558

Doi: 10.1016/j.cyto.2024.156546

Products & Services: Proteins, Expression, Isolation and Analysis

A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea

Authors: Saba Mottaghinia, Saskia Stenzel, Kyriakos Tsangaras, Nikolas Nikolaidis, Michael Laue, Karin Müller, Henriette Hölscher, Ulrike Löber, Gayle K McEwen, Stephen C Donnellan, Kevin C Rowe, Ken P Aplin, Christine Goffinet, Alex D Greenwood

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38305758

Doi: 10.1073/pnas.2220392121

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A Diversity Covering (DiCo) Plasmodium vivax apical membrane antigen-1 vaccine adjuvanted with RFASE/RSL10 yields high levels of growth-inhibitory antibodies

Authors: Bart W Faber, Lee M Yeoh, Liriye Kurtovic, Wim E M Mol, Martin Poelert, Elly Smits, Roberto Rodriguez Garcia, Marjolein Mandalawi-Van der Eijk, Nicole van der Werff, Annemarie Voorberg-van der Wel, Edmond J Remarque, James G Beeson, Clemens H M Kocken

Journal: Vaccine

PubMed ID: 38365484

Doi: 10.1016/j.vaccine.2024.02.029

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Cloning of three epsilon-class glutathione -transferase genes from (Graeser) (Lepidoptera: Notodontidae) and their response to tannic acid

Authors: Ling Zhang, Huizhen Tu, Fang Tang

Journal: Bull Entomol Res

PubMed ID: 38327098

Doi: 10.1017/S0007485323000718

Products & Services: Molecular Biology Reagents

Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus

Authors: Aura R Garrison, Vanessa Moresco, Xiankun Zeng, Curtis R Cline, Michael D Ward, Keersten M Ricks, Scott P Olschner, Lisa H Cazares, Elif Karaaslan, Collin J Fitzpatrick, Éric Bergeron, Scott D Pegan, Joseph W Golden

Journal: Nat Commun

PubMed ID: 38409240

Doi: 10.1038/s41467-024-46110-4

Products & Services: Molecular Biology Reagents

Oral administration of a recombinant modified RBD antigen of SARS-CoV-2 as a possible immunostimulant for the care of COVID-19

Authors: Norma A Valdez-Cruz, Diego Rosiles-Becerril, Constanza E Martínez-Olivares, Enrique García-Hernández, Laura Cobos-Marín, Daniel Garzón, Francisco E López-Salas, Guadalupe Zavala, Axel Luviano, Alejandro Olvera, Alejandro Alagón, Octavio T Ramírez, Mauricio A Trujillo-Roldán

Journal: Microb Cell Fact

PubMed ID: 38321489

Doi: 10.1186/s12934-024-02320-5

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Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD

Authors: Basila Moochickal Assainar, Kaushik Ragunathan, Ryan D Baldridge

Journal: Nat Commun

PubMed ID: 38351109

Doi: 10.1038/s41467-024-45541-3

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Seroprevalence of Anti-SARS-CoV-2 Antibodies in Cats during Five Waves of COVID-19 Epidemic in Thailand and Correlation with Human Outbreaks

Authors: Suporn Thongyuan, Jeeraphong Thanongsaksrikul, Potjanee Srimanote, Wallaya Phongphaew, Piyaporn Eiamcharoen, Naris Thengchaisri, Angela Bosco-Lauth, Nicola Decaro, Rungrueang Yodsheewan

Journal: Animals (Basel)

PubMed ID: 38473145

Doi: 10.3390/ani14050761

Products & Services: Molecular Biology Reagents

Production and Immunogenicity Assessment of LTp50: An -Made Chimeric Antigen Targeting S1- and S2-Epitopes from the SARS-CoV-2/BA5 Spike Protein

Authors: Alejandra Wong-Arce, Omar Gonzalez-Ortega, Andrea Romero-Maldonado, Arleth Miranda-López, Mariano García-Soto, Susan Farfán-Castro, Lourdes Betancourt-Mendiola, Samaporn Teeravechyan, Kanjana Srisutthisamphan, Mauricio Comas-García, Karla I Solís Andrade, Sergio Rosales-Mendoza

Journal: Pharmaceuticals (Basel)

PubMed ID: 38543088

Doi: 10.3390/ph17030302

Products & Services: Proteins, Expression, Isolation and Analysis

A Pseudovirus-Based Neutralization Assay for SARS-CoV-2 Variants: A Rapid, Cost-Effective, BSL-2-Based High-Throughput Assay Useful for Vaccine Immunogenicity Evaluation

Authors: Zhaohui Cai, Raj Kalkeri, Mingzhu Zhu, Shane Cloney-Clark, Benjamin Haner, Mi Wang, Bahar Osman, Dominic Dent, Sheau-Line Feng, Zach Longacre, Greg Glenn, Joyce S Plested

Journal: Microorganisms

PubMed ID: 38543552

Doi: 10.3390/microorganisms12030501

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Characterization of antibodies targeting severe fever with thrombocytopenia syndrome virus glycoprotein Gc

Authors: Kaori Sano, Miyuki Kimura, Akiko Sataka, Hideki Hasegawa, Hideki Tani, Tadaki Suzuki

Journal: Arch Virol

PubMed ID: 38308735

Doi: 10.1007/s00705-024-05968-x

Products & Services: Proteins, Expression, Isolation and Analysis

Nanofibrous MultiDomain Peptide Hydrogels Provide T Cells a 3D, Cytocompatible Environment for Cell Expansion and Antigen-Specific Killing

Authors: Viridiana Leyva-Aranda, Shailbala Singh, Maria J Telesforo, Simon Young, Cassian Yee, Jeffrey D Hartgerink

Journal: ACS Biomater Sci Eng

PubMed ID: 38385283

Doi: 10.1021/acsbiomaterials.3c01617

Products & Services: Proteins, Expression, Isolation and Analysis

GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease

Authors: Meitian Wang, Xiuqing He, Jie Li, Daobin Han, Pan You, Hui Yu, Luwen Wang, Bo Su

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38382624

Doi: 10.1016/j.bbadis.2024.167093

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Filamin A Is a Prognostic Serum Biomarker for Differentiating Benign Prostatic Hyperplasia from Prostate Cancer in Caucasian and African American Men

Authors: Nischal Mahaveer Chand, Poornima K Tekumalla, Matt T Rosenberg, Albert Dobi, Amina Ali, Gregory M Miller, Juan J Aristizabal-Henao, Elder Granger, Stephen J Freedland, Mark D Kellogg, Shiv Srivastava, David G McLeod, Niven R Narain, Michael A Kiebish

Journal: Cancers (Basel)

PubMed ID: 38398103

Doi: 10.3390/cancers16040712

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Safety and immunogenicity of CoronaVac in healthy adults: A prospective observational multicenter real-world study in Henan Province, China

Authors: Benchen Rao, Ling Wang, Mengzhao Yang, Hong Luo, Junyi Sun, Shanshuo Liu, Haiyu Wang, Xuemei Wang, Lei Li, Chengyu Yuan, Zujiang Yu, Zhigang Ren

Journal: Virulence

PubMed ID: 38326274

Doi: 10.1080/21505594.2024.2310450

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Newcastle disease virus regulates its replication by instigating oxidative stress-driven Sirtuin 7 production

Authors: Kamal Shokeen, Sachin Kumar

Journal: J Gen Virol

PubMed ID: 38376490

Doi: 10.1099/jgv.0.001961

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Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

Authors: Wonjae Sung, Min-Young Noh, Minyeop Nahm, Yong Sung Kim, Chang-Seok Ki, Young-Eun Kim, Hee-Jin Kim, Seung Hyun Kim

Journal: J Neuroinflammation

PubMed ID: 38347588

Doi: 10.1186/s12974-024-03039-1

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SOX9 Induces Orbital Fibroblast Activation in Thyroid Eye Disease Via MAPK/ERK1/2 Pathway

Authors: Min Zhou, Bingying Lin, Pengsen Wu, Yu Ke, Siyu Huang, Fan Zhang, Xiangqing Hei, Zhen Mao, Xingyi Li, Pengxia Wan, Tingting Chen, Huasheng Yang, Danping Huang

Journal: Invest Ophthalmol Vis Sci

PubMed ID: 38345552

Doi: 10.1167/iovs.65.2.25

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Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction

Authors: Dingyi Wang, Changyang Xing, Yuan Liang, Chen Wang, Ping Zhao, Xiao Liang, Qiuyang Li, Lijun Yuan

Journal: Adv Mater

PubMed ID: 38270289

Doi: 10.1002/adma.202310421

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Unveiling the Dynamic Self-Assembly of a Recombinant Dragline-Silk-Mimicking Protein

Authors: Dongqing Wu, Anamaria Koscic, Sonja Schneider, Romeo C A Dubini, Diana C Rodriguez Camargo, Sabine Schneider, Petra Rovó

Journal: Biomacromolecules

PubMed ID: 38343096

Doi: 10.1021/acs.biomac.3c01239

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Development of a live-attenuated chimeric vaccine against the emerging Usutu virus

Authors: Zheng-Jian Wang, Rong-Rong Zhang, Mei Wu, Hui Zhao, Xiao-Feng Li, Qing Ye, Cheng-Feng Qin

Journal: Vaccine

PubMed ID: 38310016

Doi: 10.1016/j.vaccine.2024.01.077

Products & Services: Proteins, Expression, Isolation and Analysis

Ultrasound-mediated gene delivery specifically targets liver sinusoidal endothelial cells for sustained FVIII expression in hemophilia A mice

Authors: Savannah M Lawton, Megan A Manson, Meng-Ni Fan, Ting-Yen Chao, Chun-Yu Chen, Peter Kim, Carley Campbell, Xiaohe Cai, Amber Vander Kooi, Carol H Miao

Journal: Mol Ther

PubMed ID: 38341614

Doi: 10.1016/j.ymthe.2024.02.010

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Candidate Expansin Genes Associated with Seed Weight in Pomegranate ( L)

Authors: Chunyan Liu, Haoyu Zhao, Jiyu Li, Zhen Cao, Bo Deng, Xin Liu, Gaihua Qin

Journal: Genes (Basel)

PubMed ID: 38397202

Doi: 10.3390/genes15020212

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Cross-Phosphorylation between AgrC Histidine Kinase and the Noncognate Response Regulator Lmo1172 in under Benzalkonium Chloride Stress

Authors: Tao Yu, Xiaojie Jiang, Xiaobo Xu, Ping Xu, Shuxing Qiu, Junlei Yin, David P Hamilton, Xiaobing Jiang

Journal: Microorganisms

PubMed ID: 38399796

Doi: 10.3390/microorganisms12020392

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Poly-γ-glutamylation of biomolecules

Authors: Ghader Bashiri, Esther M M Bulloch, William R Bramley, Madison Davidson, Stephanie M Stuteley, Paul G Young, Paul W R Harris, Muhammad S H Naqvi, Martin J Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N Baker, Christopher J Squire

Journal: Nat Commun

PubMed ID: 38346985

Doi: 10.1038/s41467-024-45632-1

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Single dose of a recombinant vesicular stomatitis virus-based vaccine elicits robust and durable neutralizing antibody response against Hantaan virus

Authors: Hui Zhang, He Liu , Jing Wei , Yamei Dang , Yuan Wang , Qiqi Yang , Liang Zhang , Chuantao Ye , Bin Wang , Xiaolei Jin , Linfeng Cheng , Hongwei Ma , Yangchao Dong , Yinghui Li , Yinlan Bai , Xin Lv , Yingfeng Lei , Zhikai Xu , Wei Ye , Fanglin Zhang

Journal: NPJ Vaccines .

PubMed ID: 38341504

Doi: 10.1038/s41541-024-00814-2

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An Enzyme-Cleavable Solubilizing-Tag Facilitates the Chemical Synthesis of Mirror-Image Protein

Authors: Yupeng Zheng, Baochang Zhang , Wei-Wei Shi, Xiangyu Deng, Tong-Yue Wang, Dongyang Han, Yuxiang Ren, Ziyi Yang, Yong-Kang Zhou, Jian Kuang, Zhi-Wen Wang, Shan Tang, Ji-Shen Zheng

Journal: Angew Chem Int Ed Engl .

PubMed ID: 38326236

Doi: 10.1002/ange.202318897

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ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis

Authors: Yongbing Yang , Yanan Wang , Zhongcheng Wang , Huanyu Yan , Yi Gong , Yingchao Hu , Yuying Jiang , Shuang Wen , Feifei Xu , Bingwei Wang , Fiachra Humphries , Yun Chen , Xi Wang , Shuo Yang

Journal: Nat Cell Biol .

PubMed ID: 38326554

Doi: 10.1038/s41556-024-01351-9

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Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8

Authors: Shan Jiang , Xi Lin , Lijie Wu , Ling Wang , Yiran Wu , Ziyi Xu , Fei Xu

Journal: Sci Adv .

PubMed ID: 38306437

Doi: 10.1126/sciadv.adj7500

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Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation

Authors: Jingyue Yu, Jinyu Hu, Margaret Baldini, Huan Lei, Lei Li, Shanshan Luo, Jielian Wu, Xupin Liu, Dan Shan, Yanfei Xie, Haihong Fang, Jun Yu

Journal: J Nat Med

PubMed ID: 38409483

Doi: 10.1007/s11418-023-01776-w

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Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Authors: Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C J M D S Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita

Journal: Membranes (Basel)

PubMed ID: 38392670

Doi: 10.3390/membranes14020043

Maternal Phlorizin Intake Protects Offspring from Maternal Obesity-Induced Metabolic Disorders in Mice via Targeting Gut Microbiota to Activate the SCFA-GPR43 Pathway

Authors: Xueran Mei, Yi Li, Xiaoyu Zhang, Xiwen Zhai, Yi Yang, Zhengjuan Li, Liping Li

Journal: J Agric Food Chem

PubMed ID: 38349207

Doi: 10.1021/acs.jafc.3c06370

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting deoxynivalenol for degradation by a chimeric manganese peroxidase/glutathione system

Authors: Xiaoyun Su, Shuai Wang, Xiaolu Wang, Wangli Ji, Honglian Zhang, Tao Tu, Nina Hakulinen, Huiying Luo, Wei Zhang, Huoqing Huang

Journal: Ecotoxicol Environ Saf

PubMed ID: 38394761

Doi: 10.1016/j.ecoenv.2024.116130

ATP10A deficiency results in male-specific infertility in mice

Authors: Adriana C Norris, Eugenia M Yazlovitskaya, Tzushan Sharon Yang, Alex Mansueto, John M Stafford, Todd R Graham

Journal: Front Cell Dev Biol

PubMed ID: 38415274

Doi: 10.3389/fcell.2024.1310593

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Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of -Isozizaene Synthase into α-Bisabolol Synthase

Authors: Samuel A Eaton, David W Christianson

Journal: Biochemistry

PubMed ID: 38420671

Doi: 10.1021/acs.biochem.3c00681

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Development of an indirect ELISA for the serodiagnosis of canine infection by Onchocerca lupi

Authors: Maria Stefania Latrofa, Viviane Noll Louzada-Flores, Carla Maia, Maureen A Kelly, Guilherme G Verocai, Cinzia Cantacessi, Domenico Otranto

Journal: Sci Rep

PubMed ID: 38336818

Doi: 10.1038/s41598-024-53759-w

Products & Services: Proteins, Expression, Isolation and Analysis

A BET inhibitor, NHWD-870, can downregulate dendritic cells maturation via the IRF7-mediated signaling pathway to ameliorate imiquimod-induced psoriasis-like murine skin inflammation

Authors: Liping Jin, Liang Dong, Shiyao Pei, Xiang Chen, Yehong Kuang, Wangqing Chen, Wu Zhu, Mingzhu Yin

Journal: Eur J Pharmacol

PubMed ID: 38311277

Doi: 10.1016/j.ejphar.2024.176382

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Efficient preparation of high-purity and intact mesenchymal stem cell-derived extracellular vesicles

Authors: Fangfang Ni, Qingfu Zhu, Hengrui Li, Fei Liu, Hao Chen

Journal: Anal Bioanal Chem

PubMed ID: 38355844

Doi: 10.1007/s00216-024-05193-0

Products & Services: Proteins, Expression, Isolation and Analysis

Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane

Authors: Rebika Shrestha, Timothy S Carpenter, Que N Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N Glosli, Cesar A López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K Gillette, Helgi I Ingólfsson, Felice C Lightstone, Andrew G Stephen, Frederick H Streitz, Dwight V Nissley, Thomas J Turbyville

Journal: Commun Biol

PubMed ID: 38418613

Doi: 10.1038/s42003-024-05916-0

Products & Services: Proteins, Expression, Isolation and Analysis

miR-193b-5p promotes GCRV replication by inhibiting autophagy via targeting deptor in grass carp (Ctenopharyngodon idellus)

Authors: Hongyan Yu, Zheyan Chen, Qiaozhen Yu, Yubang Shen, Lang Gui, Xiaoyan Xu, Jiale Li

Journal: Fish Shellfish Immunol

PubMed ID: 38365163

Doi: 10.1016/j.fsi.2024.109453

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Prediction of anticancer peptides derived from the true lectins of Phoenix dactylifera and their synergetic effect with mitotane

Authors: Othman Baothman, Ehab M. M. Ali , Salman Hosawi , Emadeldin Hassan E. Konoz, Isam M. Abu Zeid, Abrar Ahmadand Hisham N. Altayb

Journal: Frontiers in pharmacology

Doi: 10.3389/fphar.2024.1322865

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High-Level Biosynthesis of Chlorogenic Acid from Mixed Carbon Sources of Xylose and Glucose through a Rationally Refactored Pathway Network

Authors: Yuhui Wang, Haining Tan, Yanling Wang, Jing Liang Qin, Xinyu Zhao, Yuhan Di, Lijie Xie, Xiaojing Zhao, Ziyu Li, Guozhen Ma, Lingyan Jiang, Bin Liu, Di Huang

Journal: J Agric Food Chem

PubMed ID: 38330270

Doi: 10.1021/acs.jafc.3c08587

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Voltage-gated ion channels are expressed in the Malpighian tubules and anal papillae of the yellow fever mosquito (Aedes aegypti), and may regulate ion transport during salt and water imbalance

Authors: Serena Farrell, Jocelyne Dates, Nancy Ramirez, Hannah Hausknecht-Buss, Dennis Kolosov

Journal: J Exp Biol

PubMed ID: 38197515

Doi: 10.1242/jeb.246486

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A novel ex vivo assay to evaluate functional effectiveness of Plasmodium vivax transmission blocking vaccine using Pvs25 transgenic P. berghei

Authors: Yi Cao, Clifford T H Hayashi, Nirbhay Kumar

Journal: J Infect Dis

PubMed ID: 38408353

Doi: 10.1093/infdis/jiae102

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Cryo-EM structures of the plant plastid-encoded RNA polymerase

Authors: Xiao-Xian Wu, Wen-Hui Mu, Fan Li, Shu-Yi Sun, Chao-Jun Cui , Chanhong Kim, Fei Zhou , Yu Zhang

Journal: Cell

PubMed ID: 38428393

Doi: 10.1016/j.cell.2024.01.026

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Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC

Authors: Anna Miścicka, Alexander G Bulakhov, Kazushige Kuroha, Alexandra Zinoviev, Christopher U T Hellen, Tatyana V Pestova

Journal: Nucleic Acids Res

PubMed ID: 38366554

Doi: 10.1093/nar/gkae087

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Molecular mechanism of human ISG20L2 for the ITS1 clea vag e in the processing of 18S precursor ribosomal RNA

Authors: Yinliang Ma, Jiaxu Wang, Xingyi He, Yuhang Liu, Shuo Zhen, Lina An, Qian Yang, Fumin Niu, Hong Wang, Boran An, Xinyue Tai, Zhenzhen Yan, Chen Wu, Xiaoyun Yang, Xiuhua Liu

Journal: Nucleic Acids Res

PubMed ID: 38153123

Doi: 10.1093/nar/gkad1210

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Therapeutic potential of exosome derived from hepatocyte growth factor-overexpressing adipose mesenchymal stem cells in TGFβ1-stimulated hepatic stellate cells

Authors: Jin Wang, Weikang Ye, Ming Jiang, Yinong Zhou, Jie Zheng

Journal: Cytotechnology

PubMed ID: 38495297

Doi: 10.1007/s10616-023-00611-0

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Inhibition of AMPK activation in sensu stricto limits the parasite's glucose metabolism and survival

Authors: Mingzhi Yan, Hui Liu, Yansen Su, Xiaojuan Bi, Ning Yang, Renyong Lin, Guodong Lü

Journal: Antimicrob Agents Chemother

PubMed ID: 38349157

Doi: 10.1128/aac.01202-23

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Structure of the p53 degradation complex from HPV16

Authors: John C K Wang, Hannah T Baddock, Amirhossein Mafi, Ian T Foe, Matthew Bratkowski, Ting-Yu Lin, Zena D Jensvold, Magdalena Preciado López, David Stokoe, Dan Eaton, Qi Hao, Aaron H Nile

Journal: Nat Commun

PubMed ID: 38418456

Doi: 10.1038/s41467-024-45920-w

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Inhibition of NS2B-NS3 protease from all four serotypes of dengue virus by punicalagin, punicalin and ellagic acid identified from

Authors: Fouzia Ismat, Anam Tariq, Aqsa Shaheen, Raheem Ullah, Kayode Raheem, Muhammad Muddassar, Sadia Mahboob, Wasim Abbas, Mazhar Iqbal, Moazur Rahman

Journal: J Biomol Struct Dyn

PubMed ID: 38373021

Doi: 10.1080/07391102.2024.2314258

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The Humanization and Maturation of an Anti-PrPc Antibody

Authors: Cheng Zhang, Fanlei Ran, Lei Du, Xiaohui Wang, Lei Liu, Jinming Liu, Quan Chen, Yang Cao, Lijun Bi, Haiying Hang

Journal: Bioengineering (Basel)

PubMed ID: 38534516

Doi: 10.3390/bioengineering11030242

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A sustainable strategy for biosynthesis of Rebaudioside D using a novel glycosyltransferase of Solanum tuberosum

Authors: Siyuan Ma, Yuanyuan Ma

Journal: Biotechnol J

PubMed ID: 38403450

Doi: 10.1002/biot.202300628

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Preorganized cyclic modules facilitate the self-assembly of protein nanostructures

Authors: Jaka Snoj, Fabio Lapenta, Roman Jerala

Journal: Chem Sci

PubMed ID: 38455016

Doi: 10.1039/d3sc06658d

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Engineering styrene biosynthesis: designing a functional trans-cinnamic acid decarboxylase in Pseudomonas

Authors: Ana García-Franco, Patricia Godoy, Estrella Duque, Juan L Ramos

Journal: Microb Cell Fact

PubMed ID: 38419048

Doi: 10.1186/s12934-024-02341-0

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High mechanical property silk produced by transgenic silkworms expressing the Dumpy

Authors: Xiangping Dai, Xiaogang Ye, Liangen Shi, Shihua Yu, Xinqiu Wang, Boxiong Zhong

Journal: Front Bioeng Biotechnol

PubMed ID: 38410165

Doi: 10.3389/fbioe.2024.1359587

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Exploring the Impact of Primer-Template Mismatches on PCR Performance of DNA Polymerases Varying in Proofreading Activity

Authors: Ke Huang, Jilei Zhang, Jing Li, Haixiang Qiu, Lanjing Wei, Yi Yang, Chengming Wang

Journal: Genes (Basel)

PubMed ID: 38397205

Doi: 10.3390/genes15020215

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Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors

Authors: Kiara N Berríos, Aleksia Barka, Jasleen Gill, Juan C Serrano, Peter F Bailer, Jared B Parker, Niklaus H Evitt, Kiran S Gajula, Junwei Shi, Rahul M Kohli

Journal: Nucleic Acids Res

PubMed ID: 38261989

Doi: 10.1093/nar/gkae024

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Unravelling the reason for different binding behaviors exhibited by antibody aggregates towards preparative and analytical Protein A columns

Authors: Wanyuan Dong, Mengying Tian, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 38423157

Doi: 10.1016/j.pep.2024.106449

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Identification and characterization of the low molecular mass ferredoxins involved in central metabolism in Heliomicrobium modesticaldum

Authors: Karim A Walters, Kevin E Redding, John H Golbeck

Journal: Photosynth Res

PubMed ID: 38306001

Doi: 10.1007/s11120-023-01069-z

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HIV coinfection exacerbates HBV-induced liver fibrogenesis through a HIF-1α- and TGF-β1-dependent pathway

Authors: Min Xu , Charlotte Warner, Xiaoqiong Duan, Zhimeng Cheng, Andre J Jeyarajan, Wenting Li, Yongtao Wang , Tuo Shao , Shadi Salloum , Pei-Jer Chen , Xu Yu , Raymond T Chung , Wenyu Lin

Journal: J Hepatol

PubMed ID: 38311121

Doi: 10.1016/j.jhep.2024.01.026

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A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

Authors: Marian Hruska-Plochan, Vera I Wiersma, Katharina M Betz, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma , Laura De Vos, Karl Frontzek , Adriano Aguzzi, Tammaryn Lashley , Mark D Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann 4, Magdalini Polymenidou 13

Journal: Nature

PubMed ID: 38355792

Doi: 10.1038/s41586-024-07042-7

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Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel Na18 with a Unique Mechanism of Action

Authors: John M Gilchrist, Nien-Du Yang, Victoria Jiang, Bryan D Moyer

Journal: Mol Pharmacol

PubMed ID: 38195157

Doi: 10.1124/molpharm.123.000789

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The ETI-dependent receptor-like kinase 1 positively regulates effector-triggered immunity by stabilizing NLR-required for cell death 4 in Nicotiana benthamiana

Authors: Yujing Sun, Fan Liu, Mengzhu Zeng, Xinjie Zhang, Ying Cui, Zhaodan Chen, Lei Wang, Yuanpeng Xu, Jinbin Wu, Shengya Guo, Xian Dong, Suomeng Dong, Yan Wang, Yuanchao Wang

Journal: New Phytol

PubMed ID: 38362937

Doi: 10.1111/nph.19596

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SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin

Authors: Qi Xiang, Jie Wu, Yuzheng Zhou, Linhao Li, Miao Tian, Guobao Li, Zheng Zhang, Yang Fu

Journal: Microbiol Res

PubMed ID: 38430890

Doi: 10.1016/j.micres.2024.127659

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Proteomic analysis of milk fat globule membrane proteins in mature human milk of women with and without gestational diabetes mellitus

Authors: Dan Yao, Cai Shen, Jingwen Yu, Jiayue Tang, Hong Zhang, Xuebing Xu, Maolin Tu, Ling-Zhi Cheong

Journal: Food Chem

PubMed ID: 38354646

Doi: 10.1016/j.foodchem.2024.138691

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Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1

Authors: Courtney J Mycroft-West, Sahar Abdelkarim, Helen M E Duyvesteyn, Neha S Gandhi, Mark A Skidmore, Raymond J Owens, Liang Wu

Journal: Nat Commun

PubMed ID: 38351061

Doi: 10.1038/s41467-024-45419-4

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Characterization of cleavage patterns and assembly of N-terminally modified GII6 norovirus VP1 proteins

Authors: Jie Ma, Jinjin Liu, Yuqi Huo

Journal: Arch Virol

PubMed ID: 38386207

Doi: 10.1007/s00705-024-05973-0

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The Role of Hyaluronan/Receptor for Hyaluronan-Mediated Motility Interactions in the Modulation of Macrophage Polarization and Cartilage Repair

Authors: Emilia Bianchini, Yun Jin Ashley Sin, You Jin Lee, Charles Lin, Utkarsh Anil, Cassie Hamill, Mary K Cowman, Thorsten Kirsch

Journal: Am J Pathol

PubMed ID: 38403161

Doi: 10.1016/j.ajpath.2024.01.020

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Erdr1 Drives Macrophage Programming via Dynamic Interplay with YAP1 and Mid1

Authors:

Journal: Immunohorizons

PubMed ID: 38392560

Doi: 10.4049/immunohorizons.2400004

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Measurement of neuropeptide Y with molecularly imprinted polypyrrole on carbon fiber microelectrodes

Authors: Luis López, Kelly Lozano, John Cruz, Krystal Flores, Lauren Fernández-Vega, Lisandro Cunci

Journal: Neuropeptides

PubMed ID: 38335798

Doi: 10.1016/j.npep.2024.102413

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Enhancing sensitivity of qPCR assays targeting Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae by using a mutant Taq DNA polymerase

Authors: Selin Nar Otgun, Canan Zohre Ketre Kolukirik, Nuriye Unal Sahin, Mustafa Kolukirik, Gozde Girgin Ozgumus, Meral Turan, Mert Elmas, Selcuk Kilic

Journal: J Microbiol Methods

PubMed ID: 38360298

Doi: 10.1016/j.mimet.2024.106899

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Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology

Authors: Nayara Braga Emidio , Brandi M Small , Amanda R Keller , Ross W Cheloha , Laura M Wingler

Journal: Mol Pharmacol

PubMed ID: 38164609

Doi: 10.1124/molpharm.123.000797

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A quaternary ammonium-based nanosystem enables delivery of CRISPR/Cas9 for cancer therapy

Authors: Mengzhu Zhang, Siyu Sun, Xiao Liang, Zengguang Liu, Jiaxin Yin, Quanshun Li, Shengcai Yang

Journal: Biomater Sci

PubMed ID: 38240497

Doi: 10.1039/d3bm01629c

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DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α

Authors: Aidi Gao, Mingxia Zhang, Shuang Qi Zhu, Shitao Zou, Hengrui Chen, Xiaoqin Li, Chao He, Liangsu Zhou, Yan Mei, Weiqun Ding, Jundong Zhou, Yue Zhou, Yuandong Cao

Journal: Cell Death Dis

PubMed ID: 38402183

Doi: 10.1038/s41419-024-06552-6

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UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment

Authors: Yin Li, Manling Jiang, Ling Aye, Li Luo, Yong Zhang, Fengkai Xu, Yongqi Wei, Dan Peng, Xiang He, Jie Gu, Xiaofang Yu, Guoping Li, Di Ge, Chunlai Lu

Journal: Nat Commun .

PubMed ID: 38331898

Doi: 10.1038/s41467-024-45340-w

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Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery

Authors: Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, Can Wang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, Zhigang Hu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, Zhaoyu Liu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen

Journal: Nat Commun .

PubMed ID: 38378731

Doi: 10.1038/s41467-024-45690-5

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Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore

Authors: Yasmeen J Solano , Michael P Everett , Kelly S Dang , Jude Abueg , Philip D Kiser

Journal: Nature Chemical Biology

PubMed ID: 38355721

Doi: 10.1038/s41589-024-01554-z

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Unraveling the Catalytic Mechanism of Taxadiene-5α-hydroxylase from Crystallography and Computational Analyses

Authors: Xitong Song, Qian Wang, Xiaoxi Zhu, Wenhan Fang, Xiaonan Liu, Chao Shi, Zhenzhan Chang, Huifeng Jiang, and Binju Wang

Journal: ACS Catal

Doi: doi.org/10.1021/acscatal.3c05807

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Neuroprotective effects of annexin A1 tripeptide in rats with sepsis-associated encephalopathy

Authors: Qiao Cui, Nannan Qin, Yonghan Zhang, Yanmei Miao, Leiyu Xie, Xinglong Ma, Zhiquan Zhang, Peng Xie

Journal: Biotechnol Appl Biochem

PubMed ID: 38409880

Doi: 10.1002/bab.2569

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Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis

Authors: Ji Geng, Shuangxi Li, Yu Li, Zhihao Wu, Sunil Bhurtel, Suman Rimal, Danish Khan, Rani Ohja, Onn Brandman, Bingwei Lu

Journal: Nat Commun

PubMed ID: 38388640

Doi: 10.1038/s41467-024-45525-3

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Visualizing the impact of disease-associated mutations on G protein-nucleotide interactions

Authors: Kara Anazia, Lucien Koenekoop, Guillaume Ferré, Enzo Petracco, Hugo Gutiérrez-de-Teran, Matthew T Eddy

Journal: biorxiv

PubMed ID: 38352316

Doi: 10.1101/2024.01.30.578006

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