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Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

Authors: Hongyu Chen, Dangliang Liu, Jianting Guo, Abhishek Aditham, Yiming Zhou, Jiakun Tian, Shuchen Luo, Jingyi Ren, Alvin Hsu, Jiahao Huang, Franklin Kostas, Mingrui Wu, David R Liu, Xiao Wang

Journal: Nat Biotechnol

PubMed ID: 38519719

Doi: 10.1038/s41587-024-02174-7

Products & Services: Molecular Biology Reagents

Exploring the role of disulfidptosis-related signatures in immune microenvironment, prognosis and therapeutic strategies of cervical cancer

Authors: Tianzhe Jin, Taotao Yin, Ruiyi Xu, Hong Liu, Shuo Yuan, Yite Xue, Jianwei Zhang, Hui Wang

Journal: Transl Oncol

PubMed ID: 38492499

Doi: 10.1016/j.tranon.2024.101938

Products & Services: Proteins, Expression, Isolation and Analysis

Enhancing precision medicine: Bispecific antibody-mediated targeted delivery of lipid nanoparticles for potential cancer therapy

Authors: Yue Zhang, Xiaoyan Gu, Lili Huang, Yani Yang, Jun He

Journal: Int J Pharm

PubMed ID: 38467208

Doi: 10.1016/j.ijpharm.2024.123990

Products & Services: Molecular Biology Tools

Design and Preclinical Evaluation of a Nanoparticle Vaccine against Respiratory Syncytial Virus Based on the Attachment Protein G

Authors: Richard Voorzaat, Freek Cox, Daan van Overveld, Lam Le, Lisanne Tettero, Joost Vaneman, Mark J G Bakkers, Johannes P M Langedijk

Journal: Vaccines (Basel)

PubMed ID: 38543928

Doi: 10.3390/vaccines12030294

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An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy

Authors: Shibing Wang, Yuxin Li, Chuning Xu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 38458640

Doi: 10.1136/jitc-2023-008431

Products & Services: Recombinant Proteins

An Engineered Laccase from Accelerates Lignocellulose Degradation

Authors: Le Thanh Mai Pham, Kai Deng, Hemant Choudhary, Trent R Northen, Steven W Singer, Paul D Adams, Blake A Simmons, Kenneth L Sale

Journal: Biomolecules

PubMed ID: 38540744

Doi: 10.3390/biom14030324

Products & Services: Codon Optimization

In vitro digestion mimicking conditions in adults and elderly reveals digestive characteristics of pork from different cooking ways

Authors: Xiangyue Cao, Fan Zhao, Ziyi Lin, Xiaomei Sun, Xianming Zeng, Haoxi Liu, Yutong Li, Zihang Yuan, Yuan Su, Chong Wang, Guanghong Zhou

Journal: Food Res Int

PubMed ID: 38760136

Doi: 10.1016/j.foodres.2024.114204

Products & Services: Proteins, Expression, Isolation and Analysis

IgG hexamers initiate complement-dependent acute lung injury

Authors: Simon J Cleary, Yurim Seo, Jennifer J Tian, Nicholas Kwaan, David P Bulkley, Arthur Eh Bentlage, Gestur Vidarsson, Éric Boilard, Rolf Spirig, James C Zimring, Mark R Looney

Journal: J Clin Invest

PubMed ID: 38530369

Doi: 10.1172/JCI178351

Products & Services: Proteins, Expression, Isolation and Analysis

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

Authors: Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J Brophy, Hannah Arkin, Judith Feucht, Michael V Gormally, Christopher S Hackett, Korbinian N Kropp, Inaki Etxeberria, Smita S Chandran, Jae H Park, Katharine C Hsu, Michel Sadelain, Doron Betel, Christopher A Klebanoff

Journal: biorxiv

PubMed ID: 38464085

Doi: 10.1101/2024.02.26.582108

Products & Services: Gene Synthesis

Oxygen Activation in Aromatic Ring Cleaving Salicylate Dioxygenase: Detection of Reaction Intermediates with a Nitro-substituted Substrate Analog

Authors: Qian Wang, Hanbin Li, Uran Bujupi, Janosch Gröning, Andreas Stolz, Angelo Bongiorno, Rupal Gupta

Journal: Chembiochem

PubMed ID: 38363551

Doi: 10.1002/cbic.202400023

Products & Services: Molecular Biology Reagents

Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

Authors: Julie Rageul , Natalie Lo , Amy L Phi , Jinal A Patel , Jennifer J Park , Hyungjin Kim

Journal: Cell Rep

PubMed ID: 38393943

Doi: 10.1016/j.celrep.2024.113845

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Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9

Authors: Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Xiaohua Guo

Journal: Cell Commun Signal

PubMed ID: 38491522

Doi: 10.1186/s12964-024-01566-1

Products & Services: Recombinant Proteins

Reactive Oxygen Species-Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression

Authors: Liang Qi, Bo-Wen Duan, Hui Wang, Yan-Jun Liu, Han Han, Meng-Meng Han, Lei Xing, Hu-Lin Jiang, Stephen J Pandol, Ling Li

Journal: Adv Sci (Weinh)

PubMed ID: 38483920

Doi: 10.1002/advs.202401254

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Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes

Authors: Xinrui Zhou , Wan Yi Seow, Norbert Ha, Teh How Cheng, Lingfan Jiang, Jeeranan Boonruangkan, Jolene Jie Lin Goh, Shyam Prabhakar, Nigel Chou, Kok Hao Chen Affiliations expand

Journal: Nat Commun

PubMed ID: 38491027

Doi: s41467-024-46669-y

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Exploring functional genes' correlation with ()-equol concentration and new daidzein racemase identification

Authors: Yun-Fei Hu, Shu Luo, Sheng-Qi Wang, Ke-Xin Chen, Wei-Xuan Zhong, Bai-Yuan Li, Lin-Yan Cao, Hua-Hai Chen, Ye-Shi Yin

Journal: Appl Environ Microbiol

PubMed ID: 38501861

Doi: 10.1128/aem.00007-24

Products & Services: Molecular Biology Reagents

Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis

Authors: Zongtao Liu, Kan Wang, Chen Jiang, Yuqi Chen, Fayuan Liu, Minghui Xie, Wai Yen Yim, Dingyi Yao, Xingyu Qian, Shiqi Chen, Jiawei Shi, Kang Xu, Yixuan Wang, Nianguo Dong

Journal: Adv Sci (Weinh)

PubMed ID: 38502885

Doi: 10.1002/advs.202307319

Products & Services: Gene Synthesis

Association mechanism between Arabidopsis immune coreceptor BAK1 and Pseudomonas syringae effector HopF2

Authors: Rui Han, Tongtong Zhu, Lili Zhou, Meiqing Chen, Dongli Wang, Junfeng Liu

Journal: Biochem Biophys Res Commun

PubMed ID: 38579538

Doi: 10.1016/j.bbrc.2024.149871

Products & Services: Proteins, Expression, Isolation and Analysis

Nanopore analysis of cis-diols in fruits

Authors: Pingping Fan, Zhenyuan Cao, Shanyu Zhang, Yuqin Wang, Yunqi Xiao, Wendong Jia, Panke Zhang, Shuo Huang

Journal: Nat Commun

PubMed ID: 38443434

Doi: 10.1038/s41467-024-46303-x

Products & Services: Molecular Biology Reagents

MicroRNA-223-3p downregulates the inflammatory response in preeclampsia placenta via targeting NLRP3

Authors: Xueqiong Liu, Zhiyue Li, Dan Lu

Journal: BMC Pregnancy Childbirth

PubMed ID: 38448875

Doi: 10.1186/s12884-024-06371-9

Products & Services: Gene Synthesis

A Novel Dual-Fc Bispecific Antibody with Enhanced Fc Effector Function

Authors: Fulai Zhou, Yinyin Ben, Hao Jiang, Siwen Tan, Guangmao Mu, Zhengxia Zha, Shuting Dong, Sheng Huang, Yijun Zhou, Ying Jin, Mark L Chiu

Journal: Biochemistry

PubMed ID: 38426700

Doi: 10.1021/acs.biochem.3c00481

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A combinatorial strategy for HRV 3C protease engineering to achieve the N-terminal free cleavage

Authors: Meng Mei, Xian Fan, Yu Zhou, Faying Zhang, Guimin Zhang, Li Yi

Journal: Int J Biol Macromol

PubMed ID: 38521339

Doi: 10.1016/j.ijbiomac.2024.131066

Products & Services: Gene Synthesis

Characteristics of cold-adapted carbonic anhydrase and efficient carbon dioxide capture based on cell surface display technology

Authors: Yatong Wang, Quanfu Wang, Xuejing Shan, Yuwei Wu, Shumiao Hou, Ailin Zhang, Yanhua Hou

Journal: Bioresour Technol

PubMed ID: 38458264

Doi: 10.1016/j.biortech.2024.130539

Products & Services: Molecular Biology Reagents

Modular vector assembly enables rapid assessment of emerging CRISPR technologies

Authors: Abby V McGee, Yanjing V Liu, Audrey L Griffith, Zsofia M Szegletes, Bronte Wen, Carolyn Kraus, Nathan W Miller, Ryan J Steger, Berta Escude Velasco, Justin A Bosch, Jonathan D Zirin, Raghuvir Viswanatha, Erik J Sontheimer, Amy Goodale, Matthew A Greene, Thomas M Green, John G Doench

Journal: Cell Genom

PubMed ID: 38484704

Doi: 10.1016/j.xgen.2024.100519

Products & Services: Gene Synthesis

Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals

Authors: Jimena Pérez-Vargas, Gabriel Lemieux, Connor A H Thompson, Antoine Désilets, Siobhan Ennis, Guang Gao, Danielle G Gordon, Annika Lea Schulz, Masahiro Niikura, Ivan Robert Nabi, Mel Krajden, Pierre-Luc Boudreault, Richard Leduc, François Jean

Journal: Antiviral Res

PubMed ID: 38548023

Doi: 10.1016/j.antiviral.2024.105869

Products & Services: Molecular Biology Reagents

Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice

Authors: Kanwal Khalid, Hui Xuan Lim, Ayaz Anwar, Soon Hao Tan, Jung Shan Hwang, Seng-Kai Ong, Chit Laa Poh

Journal: AAPS PharmSciTech

PubMed ID: 38472523

Doi: 10.1208/s12249-024-02778-x

Products & Services: Proteins, Expression, Isolation and Analysis

HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

Authors: Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackrel

Journal: Nat Commun

PubMed ID: 38499535

Doi: 10.1038/s41467-024-46538-8

Products & Services: Molecular Biology Reagents

A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges

Authors: Xingdi Cheng 1 2, Sujia Liu 3, Jing Sun 4, Lin Liu 3, Xinghuan Ma 3, Jingjiao Li 1 2, Bangda Fan 3, Chen Yang 1 2, Yuanyuan Zhao 1 2, Shuai Liu 1, Yixing Wen 1 2, Wei Li 1 2, Simin Sun 1, Shiwei Mi 1 2, Haonan Huo 1 2, Lei Miao 5, Hao Pan 6, Xiaolan Cui 4, Jiaqi Lin 3, Xueguang Lu 1 2

Journal: Adv Mater

PubMed ID: 38145557

Doi: 10.1002/adma.20231088

Products & Services: Plasmid DNA Preparation

LysSYL: a broad-spectrum phage endolysin targeting Staphylococcus species and eradicating S aureus biofilms

Authors: He Liu, Xuemei Wei, Zhefen Wang, Xiaonan Huang, Mengyang Li, Zhen Hu, Kexin Zhang, Qiwen Hu, Huagang Peng, Weilong Shang, Yi Yang, Yuting Wang, Shuguang Lu, Xiancai Rao

Journal: Microb Cell Fact

PubMed ID: 38528536

Doi: 10.1186/s12934-024-02359-4

Products & Services: Molecular Biology Reagents

Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography

Authors: Kaylen R Meeks, Juan Ji , Mykola V Protopopov , Olga O Tarkhanova , Yurii S Moroz , John J Tanner

Journal: J Chem Inf Model

PubMed ID: 38411104

Doi: 10.1021/acs.jcim.3c01879

Products & Services: Molecular Biology Reagents

Quantification of SARS-CoV-2 monoclonal IgG mass fraction by isotope dilution mass spectrometry

Authors: G Martos, M Bedu, R D Josephs, S Westwood, R I Wielgosz

Journal: Anal Bioanal Chem

PubMed ID: 38427100

Doi: 10.1007/s00216-024-05205-z

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Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution

Authors: Elena Campos-Pardos, Santiago Uranga, Ana Picó, Ana Belén Gómez, Jesús Gonzalo-Asensio

Journal: Nat Commun

PubMed ID: 38461302

Doi: 10.1038/s41467-024-46449-8

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Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

Authors: Elena Dvoretskova, May C Ho, Volker Kittke, Florian Neuhaus, Ilaria Vitali, Daniel D Lam, Irene Delgado, Chao Feng, Miguel Torres, Juliane Winkelmann, Christian Mayer

Journal: Nat Neurosci

PubMed ID: 38528203

Doi: 10.1038/s41593-024-01611-9

Products & Services: Molecular Biology Reagents

The Evolution and Application of a Novel DNA Aptamer Targeting Bone Morphogenetic Protein 2 for Bone Regeneration

Authors: Mengping Liu, Andrew B Kinghorn, Lin Wang, Soubhagya K Bhuyan, Simon Chi-Chin Shiu, Julian A Tanner

Journal: Molecules

PubMed ID: 38542880

Doi: 10.3390/molecules29061243

Products & Services: Gene Synthesis

A pattern recognition receptor interleukin-1 receptor is involved in reproductive immunity in Macrobrachium nipponense ovary

Authors: Haifu Wan, Lei Yu, Xiaodong Cui, Shuai Guo, Shumei Mu, Xianjiang Kang

Journal: Fish Shellfish Immunol

PubMed ID: 38479568

Doi: 10.1016/j.fsi.2024.109481

Products & Services: Recombinant Proteins

Caspase-2 protects against ferroptotic cell death

Authors: Swati Dawar, Mariana C Benitez, Yoon Lim, Toby A Dite, Jumana M Yousef, Niko Thio, Sylvain Garciaz, Thomas D Jackson, Julia V Milne, Laura F Dagley, Wayne A Phillips, Sharad Kumar, Nicholas J Clemons

Journal: Cell Death Dis

PubMed ID: 38429264

Doi: 10.1038/s41419-024-06560-6

Products & Services: Mutant Libraries

Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response

Authors: Hailong Qi, Zhongjie Sun, Tianle Gao, Yanling Yao, Yu Wang, Weiwei Li, Xudong Wang, Xiaofang Wang, Defang Liu, Jian-Dong Jiang

Journal: Mol Cancer

PubMed ID: 38459592

Doi: 10.1186/s12943-024-01958-4

Products & Services: Proteins, Expression, Isolation and Analysis

Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

Authors: Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N Gopalakrishna Iyer, Eliza Li Shan Fong

Journal: Adv Sci (Weinh)

PubMed ID: 38493497

Doi: 10.1002/advs.202307129

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Mutational analysis in Corynebacterium stationis MFS transporters for improving nucleotide bioproduction

Authors: Keita Kinose, Keiko Shinoda, Tomoyuki Konishi, Hisashi Kawasaki

Journal: Appl Microbiol Biotechnol

PubMed ID: 38436751

Doi: 10.1007/s00253-024-13080-y

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Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission

Authors: Fei Wang, Yu Wang, Qing-Yang Zhang, Ke-Yu Hu, Ying-Jie Song, Lin Yang, Fan Fei, Ceng-Lin Xu, Sun-Liang Cui, Ye-Ping Ruan, Yi Wang, Zhong Chen

Journal: Acta Pharmacol Sin

PubMed ID: 38514863

Doi: 10.1038/s41401-024-01257-0

Products & Services: Proteins, Expression, Isolation and Analysis

Construction of recombinant pseudorabies virus expressing PCV2 Cap, PCV3 Cap, and IL-4: investigation of their biological characteristics and immunogenicity

Authors: Yanting Yang, Zhiwen Xu, Qian Tao, Lei Xu, Sirui Gu, Yao Huang, Zheyan Liu, Yang Zhang, Jianhua Wen, Siyuan Lai, Ling Zhu

Journal: Front Immunol

PubMed ID: 38571947

Doi: 10.3389/fimmu.2024.1339387

Products & Services: Molecular Biology Reagents

Expanding the molecular language of protein liquid-liquid phase separation

Authors: Shiv Rekhi, Cristobal Garcia Garcia, Mayur Barai, Azamat Rizuan, Benjamin S Schuster, Kristi L Kiick, Jeetain Mittal

Journal: Nat Chem

PubMed ID: 38553587

Doi: 10.1038/s41557-024-01489-x

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Engineering APOBEC3A deaminase for highly accurate and efficient base editing

Authors: Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng, Liren Wang, Dali Li

Journal: Nat Chem Biol

PubMed ID: 38553609

Doi: 10.1038/s41589-024-01595-4

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Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner

Authors: Yujian Wang, Jingchang Luo, Xiaolu Guan , Yan Zhao , Li Sun

Journal: Cell Death Discov

PubMed ID: 38458999

Doi: 10.1038/s41420-024-01887-7

Products & Services: Proteins, Expression, Isolation and Analysis

The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

Authors: Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, Ying Xia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu, Zhou Songyang

Journal: Cell Research

PubMed ID: 38448650

Doi: 10.1038/s41422-024-00938-z

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Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis

Authors: Shan Gao, Fangyu Wu, Sudagar S Gurcha, Sarah M Batt, Gurdyal S Besra, Zihe Rao, Lu Zhang

Journal: Nature

PubMed ID: 38491273

Doi: 10.1038/s41564-024-01643-8

Products & Services: Proteins, Expression, Isolation and Analysis

Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans

Authors: M Alejandra Tortorici, Amin Addetia, Albert J Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler

Journal: Immunity

PubMed ID: 38490197

Doi: 10.1016/j.immuni.2024.02.016

Products & Services: Plasmid DNA Preparation

Specific protein-RNA interactions are mostly preserved in biomolecular condensates

Authors: Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric H-T Allain

Journal: SCIENCE ADVANCES

PubMed ID: 38446881

Doi: 10.1126/sciadv.adm7435

Products & Services: PCR Cloning and Subcloning

A uniquely efficacious type of CFTR corrector with complementary mode of action

Authors: Valentina Marchesin, Lucile Monnier, Peter Blattmann, Florent Chevillard, Christine Kuntz, Camille Forny, Judith Kamper, Rolf Studer, Alexandre Bossu, Eric A Ertel, Oliver Nayler, Christine Brotschi, Jodi T Williams, John Gatfield

Journal: SCIENCE ADVANCES

PubMed ID: 38427726

Doi: 10.1126/sciadv.adk1814

Products & Services: PCR Cloning and Subcloning

FUS reads histone H3K36me3 to regulate alternative polyadenylation

Authors: Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang

Journal: Nucleic Acids Research

PubMed ID: 38499486

Doi: 10.1093/nar/gkae184

Products & Services: Proteins, Expression, Isolation and Analysis

An optimised protocol for the expression and purification of adenovirus core protein VII

Authors: Ajani Athukorala, Karla J Helbig, Brian P McSharry, Jade K Forwood, Subir Sarker

Journal: J Virol Methods

PubMed ID: 38432358

Doi: 10.1016/j.jviromet.2024.114907

Products & Services: Molecular Biology Reagents

23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling

Authors: Zeping Fan, Yaru Cui, Lanying Chen, Peng Liu, Wenbin Duan

Journal: Cancer Immunol Immunother

PubMed ID: 38554148

Doi: 10.1007/s00262-024-03662-0

Products & Services: PCR Cloning and Subcloning

mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection

Authors: Guiting Pu, Yanping Li, Tingli Liu, Hong Li, Liqun Wang, Guoliang Chen, Shanling Cao, Hong Yin, Tharheer Oluwashola Amuda, Xiaola Guo, Xuenong Luo

Journal: Parasit Vectors

PubMed ID: 38553755

Doi: 10.1186/s13071-024-06238-0

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Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics

Authors: Arshad Abdul Vahid, Muhammed Shafeek Oliyantakath Hassan, Allwin Ebenezer Sahayaraj, Ann Teres Babu, Safwa T Kizhakkeduth, Vinesh Vijayan

Journal: ACS Chem Neurosci

PubMed ID: 38433380

Doi: 10.1021/acschemneuro.3c00852

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Knockout and Replacement Gene Surgery to Treat Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa

Authors: Xuehan Sun, Chen Liang, Yangcan Chen, Tongtong Cui, Jiabao Han, Moyu Dai, Ying Zhang, Qi Zhou, Wei Li

Journal: Hum Gene Ther

PubMed ID: 38368562

Doi: 10.1089/hum.2023.201

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Uncovering the photosystem I assembly pathway in land plants

Authors: Aihong Zhang, Lin Tian, Tong Zhu, Mengyu Li, Mengwei Sun, Ying Fang, Yi Zhang, Congming Lu

Journal: Nat Plants

PubMed ID: 38503963

Doi: 10.1038/s41477-024-01658-3

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Absence of specific autoantibodies in patients with narcolepsy type 1 as indicated by an unbiased random peptide-displayed phage screening

Authors: Thi-Tuyet Trinh Tran, Thi-Hong Nhung Nguyen, Yves Dauvilliers, Roland Liblau, Xuan-Hung Nguyen

Journal: PLoS ONE

PubMed ID: 38442093

Doi: 10.1371/journal.pone.0297625

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A new trivalent recombinant protein for type 2 diabetes mellitus with oral delivery potential: design, expression, and experimental validation

Authors: Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz

Journal: J Biomol Struct Dyn

PubMed ID: 38468545

Doi: 10.1080/07391102.2024.2329290

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Bactericera cockerelli Picorna-like Virus and Three New Viruses Found Circulating in Populations of Potato/Tomato Psyllids ()

Authors: Jennifer Dahan, Gardenia E Orellana, Kaleigh B Wald, Erik J Wenninger, W Rodney Cooper, Alexander V Karasev

Journal: Viruses

PubMed ID: 38543780

Doi: 10.3390/v16030415

Products & Services: PCR Cloning and Subcloning

Rational Design of Key Enzymes to Efficiently Synthesize Phycocyanobilin in

Authors: Ziwei Wang, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Xinrui Zhao

Journal: Biomolecules

PubMed ID: 38540721

Doi: 10.3390/biom14030301

Products & Services: Proteins, Expression, Isolation and Analysis

Continuous evolution of compact protein degradation tags regulated by selective molecular glues

Authors: Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine A Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu

Journal: Science

PubMed ID: 38484051

Doi: 10.1126/science.adk4422

Products & Services: Proteins, Expression, Isolation and Analysis

Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model

Authors: Alejandra G Martinez-Perez, Rodolfo Garza-Morales, Maria de J Loera-Arias, Sheila A Villa-Cedillo, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Orlando E Flores-Maldonado, Jesus Valdes, Jose J Perez-Trujillo, Odila Saucedo-Cardenas

Journal: Mol Biol Rep

PubMed ID: 38460043

Doi: 10.1007/s11033-024-09303-0

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Characterization of Transthyretin Mutation G47V Associated with Hereditary Cardiac Amyloidosis

Authors: Xiaopeng He, Mengdie Wang, Jialu Sun, Zhengyang Yu, Xinyang Hu, Yu Liu, Xiaoping Lin

Journal: Cardiology

PubMed ID: 38437799

Doi: 10.1159/000538081

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ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis

Authors: Qianqian Lu, Wenwen Shi, Fei Zhang, Yong Ding

Journal: Plant J

PubMed ID: 38446797

Doi: 10.1111/tpj.16707

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Self-adaptive pyroptosis-responsive nanoliposomes block pyroptosis in autoimmune inflammatory diseases

Authors: Kaiwang Xu, Huang Yang, Jinghua Fang, Kaijie Qiu, Haotian Shen, Guanrui Huang, Qiangqiang Zheng, Canlong Wang, Tengjing Xu, Xinning Yu, Jiajie Wang, Yunting Lin, Jiacheng Dai, Yuting Zhong, Hongyun Song, Sunan Zhu, Siheng Wang, Zhuxing Zhou, Guang Yang, Zhengwei Mao, Zongyou Pan, Xuesong Dai

Journal: Bioactive Materials

PubMed ID: 38496034

Doi: 10.1016/j.bioactmat.2024.02.022

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G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes

Authors: Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Daniel Jutzi, Roland Montserret, Marc-David Ruepp, Romain Parent, Christophe Combet, Fabien Zoulim, Barbara Testoni

Journal: Nucleic Acids Res

PubMed ID: 38113270

Doi: 10.1093/nar/gkad1200

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MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis

Authors: Nicholas Vrettos, Jan Oppelt, Ansgar Zoch, Paraskevi Sgourdou, Haruka Yoshida, Brian Song, Ryan Fink, Dónal O'Carroll, Zissimos Mourelatos 1

Journal: Nucleic Acids Research

PubMed ID: 38520410

Doi: 10.1093/nar/gkae193

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Unveiling a Shield of Hope: A Novel Multiepitope-Based Immunogen for Cross-Serotype Cellular Defense against Dengue Virus

Authors: Nilanshu Manocha, Daphné Laubreton, Xavier Robert, Jacqueline Marvel, Virginie Gueguen-Chaignon, Patrice Gouet, Prashant Kumar, Madhu Khanna

Journal: Vaccines (Basel)

PubMed ID: 38543950

Doi: 10.3390/vaccines12030316

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Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw

Authors: Qu Xz, Sun Zq, Liu L, Ong Hs

Journal: Appl Biochem Biotechnol

PubMed ID: 38523176

Doi: 10.1007/s12010-024-04859-w

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Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations

Authors: Lucas Tricoli, Sunetra Sase, Julia Hacker, Vi Pham, Sidney Smith, Maxwell Chappell, Laura Breda, Stephanie Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Peter Kurre, Rebecca Ahrens-Nicklas, Laura Adang, Adeline Vanderver, Stefano Rivella

Journal: biorxiv

PubMed ID: 38559013

Doi: 10.1101/2024.03.14.584404

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Diverse INOSITOL PHOSPHORYLCERAMIDE SYNTHASE mutant alleles of Physcomitrium patens offer new insight into complex sphingolipid metabolism

Authors: Tegan M Haslam, Cornelia Herrfurth, Ivo Feussner

Journal: New Phytol

PubMed ID: 38523559

Doi: 10.1111/nph.19667

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Post-therapeutic cure criterion in chronic Chagas disease using Trypanosoma cruzi chimeric proteins

Authors: Tycha Bianca Sabaini Pavan, Leonardo Maia Leony, Wayner Vieira de Souza, Emily Ferreira Santos, Ramona Tavares Daltro, Natalia Erdens Maron Freitas, Larissa Carvalho Medrado Vasconcelos, Fernanda Lopes Habib, Angelo Antonio Oliveira Silva, Paola Alejandra Fiorani Celedon, Daniel Dias Sampaio, Nilson Ivo Tonin Zanchin, Silvia Andrea Longhi, Fred Luciano Neves Santos

Journal: Folia Parasitol (Praha)

PubMed ID: 38526232

Doi: 10.14411/fp.2024.004

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Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome

Authors: Rui Bai, Meng Yuan, Pu Zhang, Ting Luo, Yigong Shi, Ruixue Wan

Journal: Science

PubMed ID: 38484052

Doi: 10.1126/science.adn7272

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An intein-based biosensor to measure protein stability in vivo

Authors: Ahyun Son, John S Smetana, Scott Horowitz , Christopher W Lennon

Journal: Protein Sci

PubMed ID: 38380775

Doi: 10.1002/pro.4925

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Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells

Authors: Zhi-Liang Jing, Guang-Long Liu, Na Zhou, Dong-Yan Xu, Na Feng, Yan Lei, Li-Li Ma, Min-Shan Tang, Gui-Hui Tong, Na Tang, Yong-Jian Deng

Journal: Nature

PubMed ID: 38480774

Doi: 10.1038/s41598-024-56681-3

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Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

Authors: Dingfeng Li, Xinyi Gao, Xiaolin Ma, Ming Wang, Chuandong Cheng, Tian Xue, Feng Gao, Yong Shen, Juan Zhang, Qiang Liu

Journal: Cell Metab

PubMed ID: 38458203

Doi: 10.1016/j.cmet.2024.02.011.

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Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice

Authors: Yiling Yang, Qinggang Dai, Xin Gao, Yanfei Zhu, Mi Ri Chung, Anting Jin, Yuanqi Liu, Xijun Wang, Xiangru Huang, Siyuan Sun, Hongyuan Xu, Jingyi Liu, Lingyong Jiang

Journal: J Bone Miner Res

PubMed ID: 38477783

Doi: 10.1093/jbmr/zjae032

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Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo

Journal: Arthritis Res Ther

PubMed ID: 38509595

Doi: 10.1186/s13075-024-03308-7

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Structural determination and kinetic analysis of the transketolase from Vibrio vulnificus reveal unexpected cooperative behavior

Authors: Rainier-Numa Georges, Lionel Ballut, Guillaume Octobre, Arnaud Comte, Laurence Hecquet, Franck Charmantray, Bastien Doumèche

Journal: Protein Sci

PubMed ID: 38145310

Doi: 10.1002/pro.4884

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Supra-biological performance of immobilized enzymes enabled by chaperone-like specific non-covalent interactions

Authors: Héctor Sánchez-Morán, Joel L Kaar, Daniel K Schwartz

Journal: Nat Commun

PubMed ID: 38485940

Doi: 10.1038/s41467-024-46719-5

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Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition

Authors: Yi-Ting Huang, Ya-Ting Hsu, Pei-Ying Wu, Yu-Min Yeh, Peng-Chan Lin, Keng-Fu Hsu, Meng-Ru Shen

Journal: J Exp Clin Cancer Res

PubMed ID: 38424547

Doi: 10.1186/s13046-024-02987-z

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A SARS-CoV-2 Nanobody Displayed on the Surface of Human Ferritin with High Neutralization Activity

Authors: Wenrong Zhang, Haining Wang, Tong Wu, Xintao Gao, Yuting Shang, Zhifang Zhang, Xingjian Liu, Yinü Li

Journal: Int J Nanomedicine

PubMed ID: 38476285

Doi: 10.2147/IJN.S450829

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A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in

Authors: Shaonil Binti, Adison G Linder, Philip T Edeen, David S Fay

Journal: biorxiv

PubMed ID: 38559252

Doi: 10.1101/2024.03.12.584557

Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats

Authors: Jingjing Zhang, Tao Liu, Yanzhao Wei, Jianye Peng, Gaofeng Zeng, Peng Zhong

Journal: BMC Cardiovasc Disord

PubMed ID: 38539067

Doi: 10.1186/s12872-024-03852-9

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Extracellular vesicles promote proliferation in an animal model of regeneration

Authors: Priscilla N Avalos, Lily L Wong, David J Forsthoefel

Journal: biorxiv

PubMed ID: 38712279

Doi: 10.1101/2024.03.22.586206

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Tuning Molecular Motion Enhances Intrinsic Fluorescence in Peptide Amphiphile Nanofibers

Authors: Natchayaporn Sindhurattavej, Shreya Jampana, Mai Phuong Pham, Leonardo C Romero, Anna Grace Rogers, Griffin A Stevens, Whitney C Fowler

Journal: Biomacromolecules

PubMed ID: 38508219

Doi: 10.1021/acs.biomac.4c00050

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Comparison of Neutralizing Activity between Vaccinated and Unvaccinated Hospitalized COVID-19 Patients Infected with Delta, Omicron BA1, or Omicron BA2 Variant

Authors: Keun Ju Kim, Seo-Jin Park, Seung Gyu Yun, Sang Wook Kim, Myung-Hyun Nam, Eun Kyong Shin, Eun-Ah Chang, Dae Won Park, Chang Kyu Lee, Young Kyung Yoon, Yunjung Cho

Journal: Microorganisms

PubMed ID: 38543560

Doi: 10.3390/microorganisms12030509

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Long-term monitoring of ultratrace nucleic acids using tetrahedral nanostructure-based NgAgo on wearable microneedles

Authors: Bin Yang, Haonan Wang, Jilie Kong, Xueen Fang

Journal: Nat Commun

PubMed ID: 38431675

Doi: 10.1038/s41467-024-46215-w

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Complex -glycans are important for interspecies transmission of H7 influenza A viruses

Authors: Cindy M Spruit, Diana I Palme, Tiehai Li, María Ríos Carrasco, Alba Gabarroca García, Igor R Sweet, Maryna Kuryshko, Joshua C L Maliepaard, Karli R Reiding, David Scheibner, Geert-Jan Boons, Elsayed M Abdelwhab, Robert P de Vries

Journal: J Virol

PubMed ID: 38470143

Doi: 10.1128/jvi.01941-23

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PLD3 and PLD4 synthesize -BMP, a key phospholipid enabling lipid degradation in lysosomes

Authors: Shubham Singh, Ulrich Dransfeld, Yohannes Ambaw, Joshua Lopez-Scarim, Robert V Farese, Tobias C Walther

Journal: biorxiv

PubMed ID: 38562702

Doi: 10.1101/2024.03.21.586175

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Vesicular translocation of PARP-1 to cytoplasm causes ADP-ribosylation and disassembly of vimentin filaments during microglia activation induced by LPS

Authors: Ruiqi Chen, Lirui Xie, Yang Fan, Xiangmei Hua, Chang Y Chung

Journal: Front Cell Neurosci

PubMed ID: 38590714

Doi: 10.3389/fncel.2024.1363154

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Identification of CEP peptides encoded by the tobacco (Nicotiana tabacum) genome and characterization of their roles in osmotic and salt stress responses

Authors: Xiaolu Pan, Zhichao Deng, Rongrong Wu, Yalun Yang, Sayed Abdul Akher, Wei Li, Zenglin Zhang, Yongfeng Guo

Journal: Plant Physiol Biochem

PubMed ID: 38518396

Doi: 10.1016/j.plaphy.2024.108525

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Derivation of a novel antimicrobial peptide from the Red Sea Brine Pools modified to enhance its anticancer activity against U2OS cells

Authors: Mona Elradi, Ahmed I Ahmed, Ahmed M Saleh, Khaled M A Abdel-Raouf, Lina Berika, Yara Daoud, Asma Amleh

Journal: BMC Biotechnol

PubMed ID: 38491556

Doi: 10.1186/s12896-024-00835-8

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Variation of gene expression of fatty acid acyl CoA reductase associated with wax secretion of a scale insect, Ericerus pela, and identification of its regulation factors through the accessible chromatin analyses and yeast one-hybrid

Authors: Zuoyi Fu, Yuanchong Shi, Shuhui Yu, Qiuyu Zhao, Haifeng Mo, Pu Yang

Journal: Arch Insect Biochem Physiol

PubMed ID: 38500444

Doi: 10.1002/arch.22101

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High temperature delays and low temperature accelerates evolution of a new protein phenotype

Authors: Jia Zheng, Ning Guo, Yuxiang Huang, Xiang Guo, Andreas Wagner

Journal: Nat Commun

PubMed ID: 38553445

Doi: 10.1038/s41467-024-46332-6

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Mutagenesis and functional analysis of the varicella-zoster virus portal protein

Authors: Melissa A Visalli, Dakota J Nale Lovett, Ellyn M Kornfeind, Haley Herrington, Yi Tian Xiao, Daniel Lee, Patience Plair, S Garrett Wilder, Bret K Garza, Ashton Young, Robert J Visalli

Journal: J Virol

PubMed ID: 38517165

Doi: 10.1128/jvi.00603-23

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Tropomyosin induces the synthesis of magnesian calcite in sea urchin spines

Authors: Yugo Kato, Woosuk Ha, Zehua Zheng, Lumi Negishi, Jun Kawano, Yoshihisa Kurita, Hitoshi Kurumizaka, Michio Suzuki

Journal: J Struct Biol

PubMed ID: 38432597

Doi: 10.1016/j.jsb.2024.108074

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Transport-controlled growth decoupling for self-induced protein expression with a glycerol-repressible genetic circuit

Authors: Alvaro R Lara, Flavio Kunert, Vincent Vandenbroucke, Hilal Taymaz-Nikerel, Luz María Martínez, Juan-Carlos Sigala, Frank Delvigne, Guillermo Gosset, Jochen Büchs

Journal: Biotechnol Bioeng

PubMed ID: 38470342

Doi: 10.1002/bit.28697

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Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury

Authors: Zhixia Song, Yao Xia, Lang Shi, Hongchu Zha, Jing Huang, Xiaohong Xiang, Huiming Li, Hua Huang, Ruchi Yue, Hongtao Wang, Jiefu Zhu

Journal: Cell Mol Biol Lett

PubMed ID: 38439028

Doi: 10.1186/s11658-024-00553-1

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Comprehensive domain-specific analysis and immunoglobulin G profiling of anti-factor VIII antibodies using a bead-based multiplex immunoassay

Authors: Behnaz Pezeshkpoor, Ann-Cristin Berkemeier, Kerstin Herbst, Thilo Albert, Jens Müller, Johannes Oldenburg

Journal: J Thromb Haemost

PubMed ID: 38453023

Doi: 10.1016/j.jtha.2024.02.016

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CERK1 compromises Fusarium solani resistance by reducing jasmonate level and undergoes a negative feedback regulation via the MMK2-WRKY71 module in apple

Authors: Tingting Pei, Minghui Zhan, Dongshan Niu, Yuerong Liu, Jie Deng, Yuanyuan Jing, Pengmin Li, Changhai Liu, Fengwang Ma

Journal: Plant Cell Environ

PubMed ID: 38515330

Doi: 10.1111/pce.14896

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