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Supra-biological performance of immobilized enzymes enabled by chaperone-like specific non-covalent interactions

Authors: Héctor Sánchez-Morán, Joel L Kaar, Daniel K Schwartz

Journal: Nat Commun

PubMed ID: 38485940

Doi: 10.1038/s41467-024-46719-5

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Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition

Authors: Yi-Ting Huang, Ya-Ting Hsu, Pei-Ying Wu, Yu-Min Yeh, Peng-Chan Lin, Keng-Fu Hsu, Meng-Ru Shen

Journal: J Exp Clin Cancer Res

PubMed ID: 38424547

Doi: 10.1186/s13046-024-02987-z

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A SARS-CoV-2 Nanobody Displayed on the Surface of Human Ferritin with High Neutralization Activity

Authors: Wenrong Zhang, Haining Wang, Tong Wu, Xintao Gao, Yuting Shang, Zhifang Zhang, Xingjian Liu, Yinü Li

Journal: Int J Nanomedicine

PubMed ID: 38476285

Doi: 10.2147/IJN.S450829

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A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in

Authors: Shaonil Binti, Adison G Linder, Philip T Edeen, David S Fay

Journal: biorxiv

PubMed ID: 38559252

Doi: 10.1101/2024.03.12.584557

Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats

Authors: Jingjing Zhang, Tao Liu, Yanzhao Wei, Jianye Peng, Gaofeng Zeng, Peng Zhong

Journal: BMC Cardiovasc Disord

PubMed ID: 38539067

Doi: 10.1186/s12872-024-03852-9

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Extracellular vesicles promote proliferation in an animal model of regeneration

Authors: Priscilla N Avalos, Lily L Wong, David J Forsthoefel

Journal: biorxiv

PubMed ID: 38712279

Doi: 10.1101/2024.03.22.586206

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Tuning Molecular Motion Enhances Intrinsic Fluorescence in Peptide Amphiphile Nanofibers

Authors: Natchayaporn Sindhurattavej, Shreya Jampana, Mai Phuong Pham, Leonardo C Romero, Anna Grace Rogers, Griffin A Stevens, Whitney C Fowler

Journal: Biomacromolecules

PubMed ID: 38508219

Doi: 10.1021/acs.biomac.4c00050

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Comparison of Neutralizing Activity between Vaccinated and Unvaccinated Hospitalized COVID-19 Patients Infected with Delta, Omicron BA1, or Omicron BA2 Variant

Authors: Keun Ju Kim, Seo-Jin Park, Seung Gyu Yun, Sang Wook Kim, Myung-Hyun Nam, Eun Kyong Shin, Eun-Ah Chang, Dae Won Park, Chang Kyu Lee, Young Kyung Yoon, Yunjung Cho

Journal: Microorganisms

PubMed ID: 38543560

Doi: 10.3390/microorganisms12030509

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Long-term monitoring of ultratrace nucleic acids using tetrahedral nanostructure-based NgAgo on wearable microneedles

Authors: Bin Yang, Haonan Wang, Jilie Kong, Xueen Fang

Journal: Nat Commun

PubMed ID: 38431675

Doi: 10.1038/s41467-024-46215-w

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Complex -glycans are important for interspecies transmission of H7 influenza A viruses

Authors: Cindy M Spruit, Diana I Palme, Tiehai Li, María Ríos Carrasco, Alba Gabarroca García, Igor R Sweet, Maryna Kuryshko, Joshua C L Maliepaard, Karli R Reiding, David Scheibner, Geert-Jan Boons, Elsayed M Abdelwhab, Robert P de Vries

Journal: J Virol

PubMed ID: 38470143

Doi: 10.1128/jvi.01941-23

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PLD3 and PLD4 synthesize -BMP, a key phospholipid enabling lipid degradation in lysosomes

Authors: Shubham Singh, Ulrich Dransfeld, Yohannes Ambaw, Joshua Lopez-Scarim, Robert V Farese, Tobias C Walther

Journal: biorxiv

PubMed ID: 38562702

Doi: 10.1101/2024.03.21.586175

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Vesicular translocation of PARP-1 to cytoplasm causes ADP-ribosylation and disassembly of vimentin filaments during microglia activation induced by LPS

Authors: Ruiqi Chen, Lirui Xie, Yang Fan, Xiangmei Hua, Chang Y Chung

Journal: Front Cell Neurosci

PubMed ID: 38590714

Doi: 10.3389/fncel.2024.1363154

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of CEP peptides encoded by the tobacco (Nicotiana tabacum) genome and characterization of their roles in osmotic and salt stress responses

Authors: Xiaolu Pan, Zhichao Deng, Rongrong Wu, Yalun Yang, Sayed Abdul Akher, Wei Li, Zenglin Zhang, Yongfeng Guo

Journal: Plant Physiol Biochem

PubMed ID: 38518396

Doi: 10.1016/j.plaphy.2024.108525

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Derivation of a novel antimicrobial peptide from the Red Sea Brine Pools modified to enhance its anticancer activity against U2OS cells

Authors: Mona Elradi, Ahmed I Ahmed, Ahmed M Saleh, Khaled M A Abdel-Raouf, Lina Berika, Yara Daoud, Asma Amleh

Journal: BMC Biotechnol

PubMed ID: 38491556

Doi: 10.1186/s12896-024-00835-8

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Variation of gene expression of fatty acid acyl CoA reductase associated with wax secretion of a scale insect, Ericerus pela, and identification of its regulation factors through the accessible chromatin analyses and yeast one-hybrid

Authors: Zuoyi Fu, Yuanchong Shi, Shuhui Yu, Qiuyu Zhao, Haifeng Mo, Pu Yang

Journal: Arch Insect Biochem Physiol

PubMed ID: 38500444

Doi: 10.1002/arch.22101

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High temperature delays and low temperature accelerates evolution of a new protein phenotype

Authors: Jia Zheng, Ning Guo, Yuxiang Huang, Xiang Guo, Andreas Wagner

Journal: Nat Commun

PubMed ID: 38553445

Doi: 10.1038/s41467-024-46332-6

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Mutagenesis and functional analysis of the varicella-zoster virus portal protein

Authors: Melissa A Visalli, Dakota J Nale Lovett, Ellyn M Kornfeind, Haley Herrington, Yi Tian Xiao, Daniel Lee, Patience Plair, S Garrett Wilder, Bret K Garza, Ashton Young, Robert J Visalli

Journal: J Virol

PubMed ID: 38517165

Doi: 10.1128/jvi.00603-23

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Tropomyosin induces the synthesis of magnesian calcite in sea urchin spines

Authors: Yugo Kato, Woosuk Ha, Zehua Zheng, Lumi Negishi, Jun Kawano, Yoshihisa Kurita, Hitoshi Kurumizaka, Michio Suzuki

Journal: J Struct Biol

PubMed ID: 38432597

Doi: 10.1016/j.jsb.2024.108074

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Transport-controlled growth decoupling for self-induced protein expression with a glycerol-repressible genetic circuit

Authors: Alvaro R Lara, Flavio Kunert, Vincent Vandenbroucke, Hilal Taymaz-Nikerel, Luz María Martínez, Juan-Carlos Sigala, Frank Delvigne, Guillermo Gosset, Jochen Büchs

Journal: Biotechnol Bioeng

PubMed ID: 38470342

Doi: 10.1002/bit.28697

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Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury

Authors: Zhixia Song, Yao Xia, Lang Shi, Hongchu Zha, Jing Huang, Xiaohong Xiang, Huiming Li, Hua Huang, Ruchi Yue, Hongtao Wang, Jiefu Zhu

Journal: Cell Mol Biol Lett

PubMed ID: 38439028

Doi: 10.1186/s11658-024-00553-1

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Comprehensive domain-specific analysis and immunoglobulin G profiling of anti-factor VIII antibodies using a bead-based multiplex immunoassay

Authors: Behnaz Pezeshkpoor, Ann-Cristin Berkemeier, Kerstin Herbst, Thilo Albert, Jens Müller, Johannes Oldenburg

Journal: J Thromb Haemost

PubMed ID: 38453023

Doi: 10.1016/j.jtha.2024.02.016

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CERK1 compromises Fusarium solani resistance by reducing jasmonate level and undergoes a negative feedback regulation via the MMK2-WRKY71 module in apple

Authors: Tingting Pei, Minghui Zhan, Dongshan Niu, Yuerong Liu, Jie Deng, Yuanyuan Jing, Pengmin Li, Changhai Liu, Fengwang Ma

Journal: Plant Cell Environ

PubMed ID: 38515330

Doi: 10.1111/pce.14896

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Superior migration ability of umbilical cord-derived mesenchymal stromal cells (MSCs) toward activated lymphocytes in comparison with those of bone marrow and adipose-derived MSCs

Authors: Akiko Hori, Atsuko Takahashi, Yuta Miharu, Satoru Yamaguchi, Masatoshi Sugita, Takeo Mukai, Fumitaka Nagamura, Tokiko Nagamura-Inoue

Journal: Front Cell Dev Biol

PubMed ID: 38529405

Doi: 10.3389/fcell.2024.1329218

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Enzymatic construction of a library of even- and odd-numbered heparosan oligosaccharides and their N-sulfonated derivatives

Authors: Xintong Xi, Weijiao Zhang, Litao Hu, Ruirui Xu, Yang Wang, Guocheng Du, Jian Chen, Zhen Kang

Journal: Int J Biol Macromol

PubMed ID: 38442831

Doi: 10.1016/j.ijbiomac.2024.130501

Products & Services: Proteins, Expression, Isolation and Analysis

Heterologous expression of taxane genes confers resistance to fall armyworm in Nicotiana benthamiana

Authors: Zhenlu Xu, Yaohua Zhai, Huimin Chang, Da Yan, Pengliang Ge, Guangming Ren, Lijun Zhang, Ye Yuan, Ruoyan Wang, Wentao Li, Fuguang Li, Maozhi Ren, Huijuan Mo

Journal: Plant Cell Rep

PubMed ID: 38472660

Doi: 10.1007/s00299-024-03169-z

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The LPS-inactivating enzyme acyloxyacyl hydrolase protects the brain from experimental stroke

Authors: Yuanbo Zhu, Yue Hu, Zhongwang Liu, Luping Chang, Xue Geng, Xuhui Yin, Bing-Qiao Zhao, Wenying Fan

Journal: Transl Res

PubMed ID: 38522823

Doi: 10.1016/j.trsl.2024.03.007

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Identification and expression analysis of family gene in L

Authors: Jiao Xu, Lingyang Kong, Weichao Ren, Zhen Wang, Lili Tang, Wei Wu, Xiubo Liu, Wei Ma, Shuquan Zhang

Journal: Heliyon

PubMed ID: 38545150

Doi: 10.1016/j.heliyon.2024.e27817

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of the grass carp interleukin-23 receptor and its proinflammatory role in intestinal inflammation

Authors: Panpan Han, Jian Tang, Xufang Xu, Pengkun Meng, Kang Wu, Bingyao Sun, Xuehong Song

Journal: Int J Biol Macromol

PubMed ID: 38521334

Doi: 10.1016/j.ijbiomac.2024.130946

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Correction to "Subtilisin 3 production from Microsporum canis is independent of keratin substrate availability"

Authors:

Journal: J Basic Microbiol

PubMed ID: 38533930

Doi: 10.1002/jobm.202470023

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Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway

Authors: Quanxin Wang, Ruiqi Zhang, Yijun He, Guangmin Mao, Zhaolu Kong

Journal: Int J Radiat Biol

PubMed ID: 38442139

Doi: 10.1080/09553002.2024.2324475

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Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9

Authors: John H Kim, Aashish Shivkumar, Masaki Norimoto, Sascha Castro Lingl, Christian Seitz, Rommie E Amaro, Steve L Gonias, Jerry Yang, Wendy M Campana

Journal: Biochemistry

PubMed ID: 38450612

Doi: 10.1021/acs.biochem.3c00705

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A long-term cohort study: the immune evasion and decreasing neutralization dominated the SARS-CoV-2 breakthrough infection

Authors: Qianyun Liu, Meihua Jin, Fanghua Mei, Hui Fan, Mengxue Gu, Yuzhen Zhang, Shengnan Qian, Xue Tan, Lei Ji, Zhen Zhang, Guozhong Chen, Huan Yan, Yu Chen, Ke Lan, Qing Geng, Kun Cai, Li Zhou

Journal: Front Cell Infect Microbiol

PubMed ID: 38572316

Doi: 10.3389/fcimb.2024.1381877

Products & Services: Proteins, Expression, Isolation and Analysis

Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

Authors: Minhui Ye, Yingzhe Fang, Lu Chen, Zemin Song, Qing Bao, Fei Wang, Hao Huang, Jin Xu, Ziwen Wang, Ruijing Xiao, Meng Han, Song Gao, Hudan Liu, Baishan Jiang, Guoliang Qing

Journal: Nat Commun

PubMed ID: 38493213

Doi: 10.1038/s41467-024-46572-6

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Transmission Reducing and Enhancing Monoclonal Antibodies against Plasmodium vivax Gamete Surface Protein Pvs48/45

Authors: Geetha P Bansal, Maisa da Silva Araujo, Yi Cao, Emily Shaffer, Jessica Evangelista Araujo, Jansen Fernandes Medeiros, Clifford Hayashi, Joseph Vinetz, Nirbhay Kumar

Journal: Infect Immun

PubMed ID: 38289124

Doi: 10.1128/iai.00374-23

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The eukaryotic-like characteristics of small GTPase, roadblock and TRAPPC3 proteins from Asgard archaea

Authors: Linh T Tran, Caner Akıl, Yosuke Senju, Robert C Robinson

Journal: Commun Biol

PubMed ID: 38472392

Doi: 10.1038/s42003-024-05888-1

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Structure of the human KMN complex and implications for regulation of its assembly

Authors: Soumitra Polley, Tobias Raisch, Sabrina Ghetti, Marie Körner, Melina Terbeck, Frauke Gräter, Stefan Raunser, Camilo Aponte-Santamaría, Ingrid R Vetter, Andrea Musacchio

Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY

PubMed ID: 38459128

Doi: 10.1038/s41594-024-01230-9

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Design of amyloidogenic peptide traps

Authors: Danny D Sahtoe, Ewa A Andrzejewska, Hannah L Han, Enrico Rennella, Matthias M Schneider, Georg Meisl, Maggie Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K Bera, Lewis E Kay, Tuomas P J Knowles, David Baker

Journal: Nature Chemical Biology

PubMed ID: 38503834

Doi: 10.1038/s41589-024-01578-5

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Efficient production of isomaltulose using engineered Yarrowia lipolytica strain facilitated by non-yeast signal peptide-mediated cell surface display

Authors: Juanjuan Liu, Jiao Li, Peng Chen, Yan Zeng, Jiangang Yang, Yuanxia Sun

Journal: J Sci Food Agric

PubMed ID: 38436580

Doi: 10.1002/jsfa.13426

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miR396b/GRF6 module contributes to salt tolerance in rice

Authors: Huanran Yuan, Mingxing Cheng, Ruihua Wang, Zhikai Wang, Fengfeng Fan, Wei Wang, Fengfeng Si, Feng Gao, Shaoqing Li

Journal: Plant Biotechnol J

PubMed ID: 38454780

Doi: 10.1111/pbi.14326

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De Novo Multienzyme Synthetic Pathways for Lactic Acid Production

Authors: Xu-Wei Ding, Jing Rong, Ze-Peng Pan, Xin-Xin Zhu, Zhen-Yu Zhu, Qi Chen, Zhi-Jun Zhang, Jian-He Xu, Chun-Xiu Li, and Gao-Wei Zheng

Journal: ACS Catal

Doi: doi.org/10.1021/acscatal.3c05489

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Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Authors: Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Gengfu Xiao, Zihe Rao, Lu Lu, Leike Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu

Journal: Signal Transduct Target Ther

PubMed ID: 38443334

Doi: 10.1038/s41392-024-01758-8

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Adaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer

Authors: Vivek Subbiah, Mohamed A Gouda, J Bryan Iorgulescu, Ramona Dadu, Keyur Patel, Steven Sherman, Maria Cabanillas, Mimi Hu, Luz E Castellanos, Behrang Amini, Funda Meric-Bernstam, Tao Shen, Jie Wu

Journal: NPJ Precis Oncol

PubMed ID: 38438731

Doi: 10.1038/s41698-024-00563-4

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Evaluating microcystinase A-based approach on microcystins degradation during harvested cyanobacterial blooms

Authors: Siyu Yang, Jun Zuo, Hans-Peter Grossart, Guofei Dai, Jin Liu, Lirong Song, Nanqin Gan

Journal: Environ Pollut

PubMed ID: 38548158

Doi: 10.1016/j.envpol.2024.123878

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Microfluidic Synthesis of Scalable Layer-by-Layer Multiple Antigen Nano-Delivery Platform for SARS-CoV-2 Vaccines

Authors: Yang Xu, Kazuya Masuda, Christine Groso, Rick Hassan, Ziyou Zhou, Kelsey Broderick, Moriya Tsuji, Christopher Tison

Journal: Vaccines (Basel)

PubMed ID: 38543973

Doi: 10.3390/vaccines12030339

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The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

Authors: Hang Xu, Zihao Yuan, Kunpeng Qin, Shuai Jiang , Li Sun

Journal: Elife

PubMed ID: 38489483

Doi: 10.7554/eLife.89974

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lncCPSET1 acts as a scaffold for MLL2/COMPASS to regulate Bmp4 and promote the formation of chicken primordial germ cells

Authors: Ying Ding, Chen Zhang, Qisheng Zuo, Kai Jin, Bichun Li

Journal: Mol Genet Genomics

PubMed ID: 38551742

Doi: 10.1007/s00438-024-02127-4

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Mt10 Vaccine Protects Diversity Outbred Mice from CVB3 Infection by Producing Virus-Specific Neutralizing Antibodies and Diverse Antibody Isotypes

Authors: Mahima T Rasquinha, Kiruthiga Mone, Meghna Sur, Ninaad Lasrado, Chandirasegaran Massilamany, Stephen D Kachman, David Steffen, Jay Reddy

Journal: Vaccines (Basel)

PubMed ID: 38543901

Doi: 10.3390/vaccines12030266

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A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy

Authors: Gerhard Frey, Ana Paula G Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J Boyle, Jay M Short

Journal: MAbs

PubMed ID: 38445633

Doi: 10.1080/19420862.2024.2322562

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ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO

Authors: Diptaman Chatterjee, Lianna Y D'Brant, Benjamin M Hiller, David J Marmion, Ivette M Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer, Jeffrey H Kordower, David C Butler

Journal: Res Sq

PubMed ID: 38585932

Doi: 10.21203/rs.3.rs-4088206/v1

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ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Subspecies Invading the Central Nervous System

Authors: Zuoxi Chen, Fangzhi Du, Ruihua Zhang, Qingyun Wu, Zhiyu Lu, Rui-Li Zhang, Qianqiu Wang

Journal: ACS Infect Dis

PubMed ID: 38536197

Doi: 10.1021/acsinfecdis.3c00664

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A network pharmacological approach for the identification of potential therapeutic targets of - a complex traditional Siddha formulation

Authors: Agnes Preethy H, Yanamandram Balasubramanian Venkatakrishnan, Vigneshwar Ramakrishnan, Uma Maheswari Krishnan

Journal: J Biomol Struct Dyn

PubMed ID: 38459935

Doi: 10.1080/07391102.2024.2322612

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Nanopore analysis of salvianolic acids in herbal medicines

Authors: Pingping Fan, Shanyu Zhang, Yuqin Wang, Tian Li, Hanhan Zhang, Panke Zhang, Shuo Huang

Journal: Nat Commun

PubMed ID: 38443335

Doi: 10.1038/s41467-024-45543-1

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Characterization of c-di-AMP signaling in the periodontal pathobiont, Treponema denticola

Authors: Aidan D Moylan, Dhara T Patel, Claire O'Brien, Edward J A Schuler, Annie N Hinson, Richard T Marconi, Daniel P Miller

Journal: Mol Oral Microbiol

PubMed ID: 38436552

Doi: 10.1111/omi.12458

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Design and synthesis of APN and 3CLpro dual-target inhibitors based on STSBPT with anticoronavirus activity

Authors: Youle Zheng, Jin Feng, Yanbin Song, Yixin Yu, Min Ling, Mengjia Zhang, Haijiao Xie, Wentao Li

Journal: J Med Virol

PubMed ID: 38483056

Doi: 10.1002/jmv.29512

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Safety and immunogenicity of CoronaVac and ChAdOx1 heterologous prime-boost vaccines in an overweight population in Chiang Mai, Thailand

Authors: Kriangkrai Chawansuntati, Supachai Sakkhachornphop, Sayamon Hongjaisee, Saranta Freeouf, Patumrat Sripan, Nattaya Nusartsang, Romanee Chaiwarith, Tavitiya Sudjaritruk, Khuanchai Supparatpinyo, Jiraprapa Wipasa

Journal: Vaccine X

PubMed ID: 38549951

Doi: 10.1016/j.jvacx.2024.100475

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Machine learning developed a CD8 exhausted T cells signature for predicting prognosis, immune infiltration and drug sensitivity in ovarian cancer

Authors: Rujun Chen, Yicai Zheng, Chen Fei, Jun Ye, He Fei

Journal: Sci Rep

PubMed ID: 38461331

Doi: 10.1038/s41598-024-55919-4

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Effects of annexin B18 from Echinococcus granulosus sensu lato on mouse macrophages

Authors: Yanxin Chen, Ruiqi Hua, Guoqing Shao, Xiaowei Zhu, Wei Hou, Shengqiong Li, Aiguo Yang, Guangyou Yang

Journal: Exp Parasitol

PubMed ID: 38432406

Doi: 10.1016/j.exppara.2024.108723

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Gene regulatory network co-option is sufficient to induce a morphological novelty in

Authors: Gavin Rice, Tatiana Gaitan-Escudero, Kenechukwu Charles-Obi, Julia Zeitlinger, Mark Rebeiz

Journal: biorxiv

PubMed ID: 38585823

Doi: 10.1101/2024.03.22.584840

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miR-101-3p-mediated role of PDZK1 in hepatocellular carcinoma progression and the underlying PI3K/Akt signaling mechanism

Authors: Huihui Gao, Zhaofeng Gao, Xiaobei Liu, Xu Sun, Zhonghui Hu, Zhengwei Song, Cheng Zhang, Jianguo Fei, Xiaoguang Wang

Journal: Cell Div

PubMed ID: 38532426

Doi: 10.1186/s13008-023-00106-6

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An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo

Authors: Yingjian Li, Xue Tan, Jikai Deng, Xuemei Liu, Qianyun Liu, Zhen Zhang, Xiaoya Huang, Chao Shen, Ke Xu, Li Zhou, Yu Chen

Journal: Virol Sin

PubMed ID: 38548102

Doi: 10.1016/j.virs.2024.03.009

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Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS)

Authors: Sandeep Pal, Zandile Nare, Vincenzo A Rao, Brian O Smith, Ian Morrison, Edward A Fitzgerald, Andrew Scott, Matilda J Bingham, Thomas Pesnot

Journal: ChemMedChem

PubMed ID: 38372199

Doi: 10.1002/cmdc.202300590

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Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons

Authors: Nan Luo, Qiang Huang, Liting Dong, Wenqing Liu, Jinghui Song, Hanxiao Sun, Hao Wu, Yuan Gao, Chengqi Yi

Journal: Nat Biotechnol

PubMed ID: 38448662

Doi: 10.1038/s41587-024-02165-8

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FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

Authors: Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G MacLeod, Jennifer Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A Day, Sharon B Cantor

Journal: Nat Commun

PubMed ID: 38521768

Doi: 10.1038/s41467-024-46824-5

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Preparation and characterization of a novel humanized collagen III with repeated fragments of Gly300-Asp329

Authors: Lingying Yan, Yao Zhang, Yuxiang Zhang, Qiexin Chen, Luyao Zhang, Xiao Han, Yumo Yang, Chun Zhang, Yongdong Liu, Rong Yu

Journal: Protein Expr Purif

PubMed ID: 38508543

Doi: 10.1016/j.pep.2024.106473

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VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates

Authors: Ann Schirin Mirsanaye, Saskia Hoffmann, Melanie Weisser, Andreas Mund, Blanca Lopez Mendez, Dimitris Typas, Johannes van den Boom, Bente Benedict, Ivo A Hendriks, Michael Lund Nielsen, Hemmo Meyer, Julien P Duxin, Guillermo Montoya, Niels Mailand

Journal: Nat Commun

PubMed ID: 38503733

Doi: 10.1038/s41467-024-46760-4

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Mosquito E-20-Monooxygenase Gene Knockout Increases Dengue Virus Replication in Cells

Authors: Bo Li, Di Wang, Xiaoxue Xie, Xiaoli Chen, Guorui Liang, Dan Xing, Teng Zhao, Jiahong Wu, Xinyu Zhou, Chunxiao Li

Journal: Viruses

PubMed ID: 38675868

Doi: 10.3390/v16040525

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Expression and functional analysis of a recombinant aquaporin Z from Antarctic Pseudomonas sp AMS3

Authors: S Balakrishnan, R N Z R A Rahman, N D M Noor, W Latip, M S M Ali

Journal: Proteins

PubMed ID: 38477414

Doi: 10.1002/prot.26680

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Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin

Authors: Ruoyu Zhou, Liuqing He, Jiahao Zhang, Xiaofeng Zhang, Yanyan Li, Xiechao Zhan, Liang Tao

Journal: Nat Commun

PubMed ID: 38438396

Doi: 10.1038/s41467-024-46394-6

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Is there an immunological cross-reactivity of antibodies to the myelin oligodendrocyte glycoprotein and coronaviruses?

Authors: Kathrin Schanda, Sara Mariotto, Dagmar Rudzki, Angelika Bauer, Alessandro Dinoto, Patrizia Rossi, Sergio Ferrari, Sven Jarius, Brigitte Wildemann, Federica Boso, Bruno Giometto, Daniel Engels, Tania Kümpfel, Eva-Maria Wendel, Kevin Rostasy, Markus Reindl

Journal: Brain Commun

PubMed ID: 38576796

Doi: 10.1093/braincomms/fcae106

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Evaluation of Long-Term Adaptive Immune Responses Specific to SARS-CoV-2: Effect of Various Vaccination and Omicron Exposure

Authors: Hyunhye Kang, Jin Jung, Geon Young Ko, Jihyun Lee, Eun-Jee Oh

Journal: Vaccines (Basel)

PubMed ID: 38543935

Doi: 10.3390/vaccines12030301

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Porcine HERC6 acts as major E3 ligase for ISGylation and is auto-ISGylated for effective ISGylation in porcine

Authors: Cuiyu Ba, Chaonan Tian, Xueying Bo, Chang Xu, Yi Zhang, Xiangyu Sun, Yuchen Nan, Chunyan Wu

Journal: Microb Pathog

PubMed ID: 38554778

Doi: 10.1016/j.micpath.2024.106633

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miRNA circuit modules for precise, tunable control of gene expression

Authors: Rongrong Du, Michael J Flynn, Monique Honsa, Ralf Jungmann, Michael B Elowitz

Journal: biorxiv

PubMed ID: 38559239

Doi: 10.1101/2024.03.12.583048

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The aged microenvironment impairs BCL6 and CD40L induction in CD4 T follicular helper cell differentiation

Authors: Jacob S Fisher, Irene Adán-Barrientos, Naveen R Kumar, Jessica N Lancaster

Journal: Aging Cell

PubMed ID: 38481058

Doi: 10.1111/acel.14140

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Establishment, optimization and validation of a fluorescence polarization-based high-throughput screening assay targeting cathepsin L inhibitors

Authors: Wenwen Zhou, Baoqing You, Xiaomeng Zhao, Shuyi Si, Yan Li, Jing Zhang

Journal: SLAS Discov

PubMed ID: 38518956

Doi: 10.1016/j.slasd.2024.100153

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Histoplasma antigens as novel players for the development of new enzyme immunoassays for the serodiagnosis of histoplasmosis: A comparative study of their analytical performance

Authors: Carolina Rodríguez Laboccetta, Víctor J Briceño Fernández, Agustín Videla Garrido, Gladys B Posse, María L Cuestas, Alejandro D Nusblat

Journal: Med Mycol

PubMed ID: 38479779

Doi: 10.1093/mmy/myae023

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Chinese bayberry ( Sieb et Zucc) leaves proanthocyanidins inhibit intestinal glucose transport in human Caco-2 cells

Authors: Mengting Wang, Haiguang Mao, Zhijian Ke, Jianchu Chen, Lili Qi, Jinbo Wang

Journal: Front Pharmacol

PubMed ID: 38529186

Doi: 10.3389/fphar.2024.1284268

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The riboflavin (vitamin B2) transporter protein (SmaRT) of the human intravascular parasitic trematode Schistosoma mansoni

Authors: Akram A Da'dara, Roshni Gondane, Patrick J Skelly

Journal: Heliyon

PubMed ID: 38601580

Doi: 10.1016/j.heliyon.2024.e28271

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Isobaric Tags for Relative and Absolute Quantitation-Based Proteomics Analysis Revealed Proteins Involved in Drought Response during the Germination Stage in Faba Bean

Authors: Changyan Liu, Fangwen Yang, Li Li, Xuesong Han, Hongwei Chen, Aihua Sha, Chunhai Jiao

Journal: Metabolites

PubMed ID: 38535335

Doi: 10.3390/metabo14030175

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Analysis of Recombinant Proteins for the Serological Diagnosis of Dourine

Authors: Mirella Luciani, Gisella Armillotta, Tiziana Di Febo, Ivanka Krasteva, Simonetta Ulisse, Chiara Di Pancrazio, Caterina Laguardia, Fabrizia Perletta, Anna Serroni, Marta Maggetti, Lilia Testa, Flavio Sacchini, Mariangela Iorio, Diamante Rodomonti, Manuela Tittarelli, Maria Teresa Mercante

Journal: Vet Sci

PubMed ID: 38535861

Doi: 10.3390/vetsci11030127

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The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b

Authors: Xiaowen Jiang, Kun Zhao, Yi Sun, Xinyue Song, Chao Yi, Tianlong Xiong, Sen Wang, Yi Yu, Xiduo Chen, Run Liu, Xin Yan, Christopher L Antos

Journal: PLoS Biol

PubMed ID: 38527087

Doi: journal.pbio.3002565

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Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs

Authors: James Jiqi Wang, Sanshan Jin, Heng Zhang, Youwei Xu, Wen Hu, Yi Jiang, Chen Chen, Dao Wen Wang, H Eric Xu, Canrong Wu

Journal: Sci Adv .

PubMed ID: 38335293

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SRRM2 phase separation drives assembly of nuclear speckle subcompartments

Authors: Mengjun Zhang, Zhuang Gu, Shuanghui Guo, Yingtian Sun, Suibin Ma, Shuo Yang, Jierui Guo, Chenxi Fang, Li Shu, Yifan Ge, Zhongwen Chen, Bo Wang

Journal: Cell Rep .

PubMed ID: 38381607

Doi: 10.1016/j.celrep.2024.113827

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N-homocysteinylation of DJ-1 promotes neurodegeneration in Parkinson's disease

Authors: Tao Guo, Lingyan Zhou, Min Xiong, Jing Xiong, Juan Huang, Yiming Li, Guoxin Zhang, Guiqin Chen, Zhi-Hao Wang, Tingting Xiao, Dan Hu, Anyu Bao, Zhentao Zhang

Journal: Aging Cell

PubMed ID: 38380563

Doi: 10.1111/acel.14124

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Mitochondrial amidoxime-reducing component 1 p.Ala165Thr increases protein degradation mediated by the proteasome

Authors: Tanmoy Dutta, Kavitha Sasidharan, Ester Ciociola, Grazia Pennisi, Francesca R Noto, Lohitesh Kovooru, Tobias Kroon, Anna Lindblom, Yue Du, Mohammad Pirmoradian, Simonetta Wallin, Rosellina M Mancina, Daniel Lindén, Stefano Romeo

Journal: Liver Int

PubMed ID: 38375985

Doi: 10.1111/liv.15857

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Borrelia miyamotoi BipA-like protein, BipM, is a candidate serodiagnostic antigen distinguishing between Lyme disease and relapsing fever Borrelia infections

Authors: Kevin S Brandt, Brittany A Armstrong, Irina Goodrich, Robert D Gilmore

Journal: Ticks Tick Borne Dis

PubMed ID: 38367587

Doi: 10.1016/j.ttbdis.2024.102324

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Fusarium graminearum rapid alkalinization factor peptide negatively regulates plant immunity and cell growth via the FERONIA receptor kinase

Authors: Yujie Wang, Xin Liu, Bingqin Yuan, Xue Chen, Hanxi Zhao, Qurban Ali, Minghong Zheng, Zheng Tan, Hemin Yao, Shuqing Zheng, Jingni Wu, Jianhong Xu, Jianrong Shi, Huijun Wu, Xuewen Gao, Qin Gu

Journal: Plant Biotechnol J

PubMed ID: 38344883

Doi: 10.1111/pbi.14303

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TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli

Authors: Jinrui Sun, Ruicheng Yang, Jiyang Fu, Dong Huo, Xinyi Qu, Chen Tan, Huanchun Chen, Xiangru Wang

Journal: Cell Commun Signal

PubMed ID: 38360663

Doi: 10.1186/s12964-023-01383-y

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AbImmPred: An immunogenicity prediction method for therapeutic antibodies using AntiBERTy-based sequence features

Authors: Hong Wang, Xiaohu Hao, Yuzhuo He, Long Fan

Journal: PLoS ONE

PubMed ID: 38394128

Doi: 10.1371/journal.pone.0296737

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Autoinhibition and activation of myosin VI revealed by its cryo-EM structure

Authors: Fengfeng Niu, Lingxuan Li, Lei Wang, Jinman Xiao, Shun Xu, Yong Liu, Leishu Lin, Cong Yu, Zhiyi Wei

Journal: Nat Commun

PubMed ID: 38331992

Doi: 10.1038/s41467-024-45424-7

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Enhancing CAR Macrophage Efferocytosis Via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling

Authors: Skylar T Chuang, Joshua B Stein, Sarah Nevins, Cemile Kilic Bektas, Hye Kyu Choi, Wan-Kyu Ko, Hyunjun Jang, Jihun Ha, Ki-Bum Lee

Journal: Adv Mater

PubMed ID: 38353580

Doi: 10.1002/adma.202308377

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Cutting Edge: Characterization of Low Copy Number Human Angiotensin-Converting Enzyme 2-Transgenic Mice as an Improved Model of SARS-CoV-2 Infection

Authors: Christine M Bradshaw, Teodora Georgieva, Trevor N Tankersley, Tama Taylor-Doyle, Larry Johnson, Jennifer L Uhrlaub, David Besselsen, Janko Ž Nikolich

Journal: J Immunol

PubMed ID: 38197714

Doi: 10.4049/jimmunol.2300591

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Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects

Authors: Yi-Lin Zhang, Tao-Tao Tang, Wei-Jie Ni, Zhong-Tang Li, Liang-Yun-Zi Jiang, Yao Wang, Xuan Zhou, Jing-Yuan Cao, Qing Yin, Wei Jiang, Ya-Jie Zhao, Wei-Hua Gan, Ai-Qing Zhang, Zuo-Lin Li, Yi Wen, Lin-Li Lv, Bi-Cheng Liu, Bin Wang

Journal: Int J Biol Sci

PubMed ID: 38481813

Doi: 10.7150/ijbs.90872

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Precise Engineering of Growth Factor Presentation Using Extracellular Microenvironment-Mimicking Microfluidic Microparticles

Authors: Mohammad Mahdi Hasani-Sadrabadi, Weihao Yuan, Luiza de Almeida Queiroz Ferreira, Zeyang Liu, Jun Shen, Patricia Sarrión, Fatemeh Sharifi, Atefeh Malek-Khatabi, Erfan Dashtimoghadam, Bo Yu, Sahar Ansari, Alireza Moshaverinia

Journal: ACS Biomater Sci Eng

PubMed ID: 38347681

Doi: 10.1021/acsbiomaterials.3c01922

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Distribution analysis of TRH in Bactrocera dorsalis using a CRISPR/Cas9-mediated reporter knock-in strain

Authors: Feiyue Teng, Fengyi Guo, Jimei Feng, Yongyue Lu, Yixiang Qi

Journal: Insect Mol Biol

PubMed ID: 38411032

Doi: 10.1111/imb.12901

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Arabidopsis thaliana RHAMNOSE 1 condensate formation drives UDP-rhamnose synthesis

Authors: Sterling Field, Yanniv Dorone, Will P Dwyer, Jack A Cox, Dan Raba, John Froehlich, Madison Blea, Olivia M S Carmo, Ian S Wallace, Renee Hastings, Steven Boeynaems, Seung Y Rhee

Journal: biorxiv

PubMed ID: 38464008

Doi: 10.1101/2024.02.15.580454

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Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs

Authors: Xin Xu, Timothy J Herdendorf, Huiquan Duan, Denise L Rohlik, Sourav Roy, Hinman Zhou, Haya Alkhateeb, Sanjay Khandelwal, Qilong Zhou, Ping Li, Gowthami M Arepally, John K Walker, Brandon L Garcia, Brian V Geisbrecht

Journal: J Immunol

PubMed ID: 38149922

Doi: 10.4049/jimmunol.2300630

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Analysis of heterologous expression of phaCBA promotes the acetoin stress response mechanism in Bacillus subtilis using transcriptomics and metabolomics approaches

Authors: Tao Li, Haixiang Li, Lei Zhong, Yufei Qin, Gege Guo, Zhaoxing Liu, Ning Hao, Pingkai Ouyang

Journal: Microb Cell Fact

PubMed ID: 38383407

Doi: 10.1186/s12934-024-02334-z

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Impact of sex on humoral immunity with live influenza B virus vaccines in mice

Authors: Stivalis Cardenas-Garcia, C Joaquín Cáceres, Aarti Jain, Ginger Geiger, Jong-Suk Mo, L Claire Gay, Brittany Seibert, Algimantas Jasinskas, Rie Nakajima, Daniela S Rajao, D Huw Davies, Daniel R Perez

Journal: npj Vaccines

PubMed ID: 38409236

Doi: 10.1038/s41541-024-00827-x

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Chimeric nanobody-decorated liposomes by self-assembly

Authors: Md Mofizur Rahman, Jing Wang, Guosheng Wang, Zhipeng Su, Yizeng Li, Yundi Chen, Jinguo Meng, Yao Yao, Lefei Wang, Stephan Wilkens, Jifu Tan, Juntao Luo, Tao Zhang, Chuandong Zhu, Sung Hyun Cho, Lixue Wang, Luke P Lee, Yuan Wan

Journal: Nat Nanotechnol

PubMed ID: 38374413

Doi: 10.1038/s41565-024-01620-6

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Characterization of NAC Gene Family in and Functional Analysis of , an Osmotic and Cold-Stress-Induced NAC Gene

Authors: Tashi Dorjee, Yican Cui, Yuxin Zhang, Qi Liu, Xuting Li, Batu Sumbur, Hongxi Yan, Jie Bing, Yuke Geng, Yijun Zhou, Fei Gao

Journal: Biomolecules

PubMed ID: 38397419

Doi: 10.3390/biom14020182

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