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Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers

Authors: Sarah Schmidt, Meron Mengistu, Stephane Daffis, Sarah Ahmadi-Erber, Daniela Deutschmann, Tetiana Grigoriev, Ruth Chu, Cleo Leung, Adrian Tomkinson, Mohammad Nizam Uddin, Safiehkhatoon Moshkani, Michael D Robek, Jason Perry, Henning Lauterbach, Klaus Orlinger, Simon P Fletcher, Scott Balsitis

Journal: J Infect Dis

PubMed ID: 37602681

Doi: 10.1093/infdis/jiad340

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Structure-Based Optimization of One Neutralizing Antibody against SARS-CoV-2 Variants Bearing the L452R Mutation

Authors: Yamin Chen, Jialu Zha, Shiqi Xu, Jiang Shao, Xiaoshan Liu, Dianfan Li, Xiaoming Zhang

Journal: Viruses

PubMed ID: 38675908

Doi: 10.3390/v16040566

Products & Services: Molecular Biology Reagents

Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial

Authors: Mark Yarchoan, Edward J Gane, Thomas U Marron, Renzo Perales-Linares, Jian Yan, Neil Cooch, Daniel H Shu, Elana J Fertig, Luciane T Kagohara, Gabor Bartha, Josette Northcott, John Lyle, Sarah Rochestie, Joann Peters, Jason T Connor, Elizabeth M Jaffee, Ildiko Csiki, David B Weiner, Alfredo Perales-Puchalt, Niranjan Y Sardesai

Journal: Nat Med

PubMed ID: 38584166

Doi: 10.1038/s41591-024-02894-y

Products & Services: Molecular Biology Reagents

Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/Sirt1/HMGB1 signaling pathway in type 1 diabetic rats

Authors: Wenhui Yao, Rongpin Tao, Kai Wang, Xuansheng Ding

Journal: Chin J Nat Med

PubMed ID: 38658093

Doi: 10.1016/S1875-5364(24)60618-7

Products & Services: Molecular Biology Reagents

Chimeric Porcine Parvovirus VP2 Virus-like Particles with Epitopes of South African Serotype 2 Foot-and-Mouth Disease Virus Elicits Specific Humoral and Cellular Responses in Mice

Authors: Qian Li, Xusheng Ma, Yaner Shen, Junfei Dai, Xiaofeng Nian, Xiaofen Shang, Jiao Chen, Ashenafi Kiros Wubshet, Jie Zhang, Haixue Zheng

Journal: Viruses

PubMed ID: 38675963

Doi: 10.3390/v16040621

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Correction: Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo

Journal: Arthritis Res Ther

PubMed ID: 38600545

Doi: 10.1186/s13075-024-03319-4

Products & Services: Proteins, Expression, Isolation and Analysis

Functional screening of the Arabidopsis 2C protein phosphatases family identifies PP2C15 as a negative regulator of plant immunity by targeting BRI1-associated receptor kinase 1

Authors: Zhihong Diao, Rongqian Yang, Yizhu Wang, Junmei Cui, Junhao Li, Qiqi Wu, Yaxin Zhang, Xiaosong Yu, Benqiang Gong, Yan Huang, Guozhi Yu, Huipeng Yao, Jinya Guo, Huaiyu Zhang, Jinbo Shen, Andrea A Gust, Yi Cai

Journal: Mol Plant Pathol

PubMed ID: 38561315

Doi: 10.1111/mpp.13447

Products & Services: Proteins, Expression, Isolation and Analysis

Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid

Authors: Huaying Zhao, Abdullah M Syed, Mir M Khalid, Ai Nguyen, Alison Ciling, Di Wu, Wai-Ming Yau, Sanjana Srinivasan, Dominic Esposito, Jennifer A Doudna, Grzegorz Piszczek, Melanie Ott, Peter Schuck

Journal: Nucleic Acids Res

PubMed ID: 38587193

Doi: 10.1093/nar/gkae256

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Photo-Responsive Decellularized Small Intestine Submucosa Hydrogels

Authors: Van Thuy Duong, Han Dang Nguyen, Ngoc Ha Luong, Chun-Yi Chang, Chien-Chi Lin

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202401952

Products & Services: Peptide Synthesis

Assessing Weak Anion Binding to Small Peptides

Authors: Corinne L D Gibb, Thien H Tran, Bruce C Gibb

Journal: Journal of the American Chemical Society

PubMed ID: 38592238

Doi: 10.1021/acs.jpcb.4c00657

Products & Services: Peptide Synthesis

Detecting m6A at single-molecular resolution via direct RNA sequencing and realistic training data

Authors: Adrian Chan, Isabel S Naarmann-de Vries, Carolin P M Scheitl, Claudia Höbartner,Christoph Dieterich

Journal: Nature Communications

PubMed ID: 38637518

Doi: 10.1038/s41467-024-47661-2

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Immune microniches shape intestinal T function

Authors: Yisu Gu, Raquel Bartolomé-Casado, Chuan Xu, Alice Bertocchi, Alina Janney, Cornelia Heuberger, Claire F Pearson, Sarah A Teichmann, Emily E Thornton, Fiona Powrie

Journal: Nature

PubMed ID: 38570678

Doi: 10.1038/s41586-024-07251-0

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Antibacterial efficacy and mechanism of Cyprinus carpio chemokine-derived L-10 against multidrug-resistant Escherichia coli infections

Authors: Hao Lu, Chenchen Wang, Wenjia Lu, Xiaodan Li, Gaoyan Wang, Wenqi Dong, Xiangru Wang, Huanchun Chen, Chen Tan

Journal: International Journal of Antimicrobial Agents

PubMed ID: 38325720

Doi: 10.1016/j.ijantimicag.2024.107104

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A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

Authors: Pei-Zhen Han, Wei-Dong Ye, Peng-Cheng Yu, Li-Cheng Tan, Xiao Shi, Xu-Feng Chen, Cong He, Jia-Qian Hu, Wen-Jun Wei, Zhong-Wu Lu, Ning Qu, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang

Journal: JCI Insight

PubMed ID: 38478516

Doi: 10.1172/jci.insight.173712

Products & Services: Molecular Biology Reagents

The Novel MFG-E8-derived Oligopeptide, MOP3, Improves Outcomes in a Preclinical Murine Model of Neonatal Sepsis

Authors: Colleen P Nofi, Jose M Prince, Monowar Aziz, Ping Wang

Journal: J Pediatr Surg

PubMed ID: 38582704

Doi: 10.1016/j.jpedsurg.2024.03.025

Products & Services: Peptide Synthesis

Separation and purification of short-, medium-, and long-stranded RNAs by RP-HPLC using different mobile phases and C columns with various pore sizes

Authors: Makoto Ozaki, Tomomi Kuwayama, Motoshi Shimotsuma, Tsunehisa Hirose

Journal: Anal Methods

PubMed ID: 38445900

Doi: 10.1039/d4ay00114a

Products & Services: Gene Synthesis

Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort

Authors: Brett M Cassidy, Fei Jiang, Jianguo Lin, Jian-Min Chen, Grace E Curry, Guo-Xiu Ma, Steven J Wilhelm, Shun-Jiang Deng, Guoying Zhu, Zhuan Liao, Mark E Lowe, Xunjun K Xiao, Wen-Bin Zou

Journal: Pancreatology

PubMed ID: 38485544

Doi: 10.1016/j.pan.2024.03.002

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WDR4 promotes HCC pathogenesis through N-methylguanosine by regulating and interacting with METTL1

Authors: Rui Dong, Chuanxu Wang, Bo Tang, Yayu Cheng, Xuehui Peng, Xiaomin Yang, Bing Ni, Jing Li

Journal: Cell Signal

PubMed ID: 38493882

Doi: 10.1016/j.cellsig.2024.111145

Products & Services: Proteins, Expression, Isolation and Analysis

Cross-reactive CD8 T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs)

Authors: Beatrice Cavalluzzo, Marie Christine Viuff, Siri Amanda Tvingsholm, Concetta Ragone, Carmen Manolio, Angela Mauriello, Franco M Buonaguro, Maria Lina Tornesello, Francesco Izzo, Alessandro Morabito, Sine Reker Hadrup, Maria Tagliamonte, Luigi Buonaguro

Journal: J Exp Clin Cancer Res

PubMed ID: 38509571

Doi: 10.1186/s13046-024-03004-z

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Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro

Authors: Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Takami Yokogawa, Aiko Sano, Ryuichiro Suzuki, Masashi Kitamura

Journal: J Nat Med

PubMed ID: 38512650

Doi: 10.1007/s11418-024-01788-0

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Diagnosis of fasciolosis antibodies in Brazilian cattle through ELISA employing both native and recombinant antigens

Authors: Guilherme Drescher, Hellen Geremias Dos Santos, Mariane Marques da Guarda Pinto, Luis Gustavo Morello, Fabiano Borges Figueiredo

Journal: Microbiol Spectr

PubMed ID: 38534120

Doi: 10.1128/spectrum.00095-24

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Structural insights into human EMC and its interaction with VDAC

Authors: Mingyue Li, Chunli Zhang, Yuntao Xu, Shaobai Li, Chenhui Huang, Jian Wu, Ming Lei

Journal: Aging (Albany NY)

PubMed ID: 38517390

Doi: 10.18632/aging.205660

Products & Services: Proteins, Expression, Isolation and Analysis

Expression, purification, and biological activity evaluation of cathepsin L in mammalian cells

Authors: Wenwen Zhou, Baoqing You, Yifan Zheng, Shuyi Si, Yan Li, Jing Zhang

Journal: Biosci Biotechnol Biochem

PubMed ID: 38271604

Doi: 10.1093/bbb/zbae005

Products & Services: Molecular Biology Reagents

A T cell-based SARS-CoV-2 spike protein vaccine provides protection without antibodies

Authors: Juan Shi, Jian Zheng, Xiujuan Zhang, Wanbo Tai, Ryan Compas, Jack Deno, Natalie Jachym, Abhishek K Verma, Gang Wang, Xiaoqing Guan, Abby E Odle, Yushun Wan, Fang Li, Stanley Perlman, Liang Qiao, Lanying Du

Journal: JCI Insight

PubMed ID: 38456504

Doi: 10.1172/jci.insight.155789

Products & Services: Molecular Biology Reagents

Development and Evaluation of an Immunoinformatics-Based Multi-Peptide Vaccine against Infection

Authors: Sean Jeffreys, Megan P Tompkins, Jadelynn Aki, Sara B Papp, James P Chambers, M Neal Guentzel, Chiung-Yu Hung, Jieh-Juen Yu, Bernard P Arulanandam

Journal: Vaccines (Basel)

PubMed ID: 38675740

Doi: 10.3390/vaccines12040358

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Preparation and immunogenicity evaluation of C-HapS-P6 fusion protein vaccine against nontypeable Haemophilus influenzae in mice

Authors: Nan Hu, Weifeng Li, Zihong Zhao, Yueli Chang, Cai Wang, Yutuo Zhang

Journal: Int J Med Microbiol

PubMed ID: 38461565

Doi: 10.1016/j.ijmm.2024.151616

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of Probiotic Properties and Whole-Genome Analysis of N5 and N7 Isolated from Swine

Authors: Kun Wang, Yu Wang, Lifang Gu, Jinyan Yu, Qianwen Liu, Ruiqi Zhang, Guixin Liang, Huan Chen, Fang Gu, Haoyu Liu, Xin'an Jiao, Yunzeng Zhang

Journal: Microorganisms

PubMed ID: 38674616

Doi: 10.3390/microorganisms12040672

Products & Services: DNA Sequencing

Dual mechanisms contribute to enhanced voltage dependence of an electric fish potassium channel

Authors: Jelena Todorovic, Immani Swapna, Antonio Suma, Vincenzo Carnevale, Harold Zakon

Journal: Biophys J

PubMed ID: 38429925

Doi: 10.1016/j.bpj.2024.02.028

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Antigenicity, epitope mapping, and intracellular distribution of the NSP7α protein of porcine reproductive and respiratory syndrome virus

Authors: Tao Wang, Da-Song Xia, Xiao-Xiao Tian, Yong-Bo Yang, Tong-Qing An

Journal: Int J Biol Macromol

PubMed ID: 38493809

Doi: 10.1016/j.ijbiomac.2024.130944

Products & Services: Proteins, Expression, Isolation and Analysis

Safety and Immunogenicity of a Messenger RNA-Based Cytomegalovirus Vaccine in Healthy Adults: Results From a Phase 1, Randomized, Clinical Trial

Authors: Carlos Fierro, Daniel Brune, Marian Shaw, Howard Schwartz, Conor Knightly, Jiang Lin, Andrea Carfi, Andrew Natenshon, Shiva Kalidindi, Caroline Reuter, Jacqueline Miller, Lori Panther

Journal: J Infect Dis

PubMed ID: 38478705

Doi: 10.1093/infdis/jiae114

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Rapid and Mechanically Robust Immobilization of Proteins on Silica Studied at the Single-Molecule Level by Force Spectroscopy and Verified at the Macroscopic Level

Authors: Xiaoxu Zhang, Yayan Xie, Duo Huang, Xiaozhong Zhang, Xiaoyu Tang, Long Chen, Shi-Zhong Luo, Jizhong Lou, Chengzhi He

Journal: ACS Appl Mater Interfaces

PubMed ID: 38520330

Doi: 10.1021/acsami.3c18699

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The protein methyltransferase TrSAM inhibits cellulase gene expression by interacting with the negative regulator ACE1 in Trichoderma reesei

Authors: Zhihua Zhu, Gen Zou, Shunxing Chai, Meili Xiao, Yinmei Wang, Pingping Wang, Zhihua Zhou

Journal: Commun Biol

PubMed ID: 38548869

Doi: 10.1038/s42003-024-06072-1

Products & Services: Proteins, Expression, Isolation and Analysis

The human microbiota is a beneficial reservoir for SARS-CoV-2 mutations

Authors: Birong Cao, Xiaoxi Wang, Wanchao Yin, Zhaobing Gao, Bingqing Xia

Journal: MBio

PubMed ID: 38530031

Doi: 10.1128/mbio.03187-23

Products & Services: Proteins, Expression, Isolation and Analysis

Phenotypic characterization of sorghum seedlings and expression patterns of SNAC1 and DREB1A genes under water‑stress: an insight towards developing resilient cultivars

Authors: David Adedayo Animasaun · Khadijat Adetoun Adedoyin · Afeez Taiwo Bakare · Kabir Adeniran Mustapha · Mary Anuoluwapo Akinbobola · Kafayat Folasade Awujoola · Jonathan Toyin Ogunjobi

Journal: springerlink

Doi: 10.1007/s10722-024-01956-x

Products & Services: Gene Synthesis

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Authors: Stian Foss , Siri A Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz , Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg

Journal: Nature Communications

PubMed ID: 38453922

Doi: 10.1038/s41467-024-46321-9

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Decoding chromatin states by proteomic profiling of nucleosome readers

Authors: Saulius Lukauskas, Andrey Tvardovskiy, Nhuong V Nguyen , Mara Stadler, Peter Faull, Tina Ravnsborg, Bihter Özdemir Aygenli, Scarlett Dornauer, Helen Flynn, Rik G H Lindeboom, Teresa K Barth, Kevin Brockers, Stefanie M Hauck, Michiel Vermeulen, Ambrosius P Snijders, Christian L Müller, Peter A DiMaggio, Ole N Jensen, Robert Schneider, Till Bartke

Journal: Nature

PubMed ID: 38448585

Doi: 10.1038/s41586-024-07141-5

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Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

Authors: Franziska K Kaiser, Mariana Gonzalez Hernandez, Nadine Krüger, Ellinor Englund, Wenjuan Du, Anna Z Mykytyn, Mathijs P Raadsen, Mart M Lamers

Journal: Nature Communications

PubMed ID: 38485931

Doi: 10.1038/s41467-024-46443-0

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Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions

Authors: Rosa Antón, Miguel Á Treviño, David Pantoja-Uceda, Sara Félix, María Babu, Eurico J Cabrita, Markus Zweckstetter, Philip Tinnefeld, Andrés M Vera, Javier Oroz

Journal: Nature

PubMed ID: 38431667

Doi: 10.1038/s41467-024-46236-5

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An alphacoronavirus polymerase structure reveals conserved replication factor functions

Authors: Thomas K Anderson, Peter J Hoferle, Kennan J Chojnacki, Kenneth W Lee, Joshua J Coon, Robert N Kirchdoerfer

Journal: Nucleic Acids Research

PubMed ID: 38442273

Doi: 10.1093/nar/gkae153

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Determinants of CRISPR Cas12a nuclease activation by DNA and RNA targets

Authors: Eric A Nalefski, Remy M Kooistra, Ishira Parikh, Samantha Hedley, Karunya Rajaraman, Damian Madan

Journal: Nucleic Acids Research

PubMed ID: 38477377

Doi: 10.1093/nar/gkae152

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Effects of Drag-Reducing Polymers on Hemodynamics and Whole Blood-Endothelial Interactions in 3D-Printed Vascular Topologies

Authors: Louis S Paone, Matthew Szkolnicki, Brandon J DeOre, Kiet A Tran, Noah Goldman, Allison M Andrews, Servio H Ramirez, Peter A Galie

Journal: ACS Appl Mater Interfaces

PubMed ID: 38488736

Doi: 10.1021/acsami.3c17099

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Structurally Diverse Bisbenzylisoquinoline Alkaloids with Antiadipogenic Activity through Downregulation from the Embryo of Seeds

Authors: Peiliang Zhang, Jiadong Li, Jiyao Shi, Zhihong Cheng, Tao Wu

Journal: J Nat Prod

PubMed ID: 38483204

Doi: 10.1021/acs.jnatprod.3c01290

Products & Services: Proteins, Expression, Isolation and Analysis

LINC00869 Promotes Hepatocellular Carcinoma Metastasis via Protrusion Formation

Authors: Xiaowen Shao, Yamei Dang, Tingting Zhang, Nan Bai, Jianing Huang, Mengya Guo, Li Sun, Minghe Li, Xiao Sun, Xinran Zhang, Feng Han, Ning Zhang, Hao Zhuang, Yongmei Li

Journal: Mol Cancer Res

PubMed ID: 37934195

Doi: 10.1158/1541-7786.MCR-23-0414

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insights into peptidoglycan glycosidase EtgA binding to the inner rod protein EscI of the type III secretion system via a designed EscI-EtgA fusion protein

Authors: J Boorman, X Zeng, J Lin, F van den Akker

Journal: Protein Sci

PubMed ID: 38380768

Doi: 10.1002/pro.4930

Products & Services: Proteins, Expression, Isolation and Analysis

Immunoprotective effect and mechanism of rEgP29 against CD4 T cell-deficient mice with infection

Authors: Ming Li, Yazhou Zhu, Zihua Li, Jiahui Song, Wei Zhao

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 38151996

Doi: 10.3724/abbs.2023282

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Computational aptamer design for spike glycoprotein (S) (SARS CoV-2) detection with an electrochemical aptasensor

Authors: Alessia Cossettini, Laura Pasquardini, Antonello Romani, Aldo Feriani, Debora Pinamonti, Marisa Manzano

Journal: Appl Microbiol Biotechnol

PubMed ID: 38470514

Doi: 10.1007/s00253-024-13066-w

Products & Services: DNA Sequencing

The Hsa_circ_0105558/miR-182-5p/ATF6 Cascade Affects HO-Triggered Oxidative Damage and Apoptosis of Human Lens Epithelial Cells

Authors: Wei Mao, Zhe Zhang

Journal: Biochem Genet

PubMed ID: 38530576

Doi: 10.1007/s10528-024-10753-1

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Fibrinogen deposition promotes neuroinflammation and fibrin-derived γ peptide ameliorates neurological deficits after ischemic stroke

Authors: Lu Han, Yaying Song, Weiwei Xiang, Ze Wang, Yishu Wang, Xiajun Zhou, De-Sheng Zhu, Yangtai Guan

Journal: Int Immunopharmacol

PubMed ID: 38489969

Doi: 10.1016/j.intimp.2024.111831

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A Novel Polymer Nanoparticle Polydimethyl Diallyl Ammonium Chloride as An Adjuvant Enhances the Immune Response of SARS-CoV-2 Subunit Vaccine

Authors: Lili Ren, Chengcheng Ouyang, Shuqing Zhao, Qiqi Zheng, Weilu Guo, Baochao Fan, Jinzhu Zhou, Wei Zhang, Mi Hu, Jizong Li, Bin Li

Journal: Adv Healthc Mater

PubMed ID: 38436662

Doi: 10.1002/adhm.202304575

Products & Services: Proteins, Expression, Isolation and Analysis

Hepcidin contributes to largemouth bass (Micropterus salmoides) against bacterial infections

Authors: Weixiang Zhang, Bo Li, Ruying Yu, Wenyan Xu, Xiaoling Liu, Jianguo Su, Gailing Yuan

Journal: Int J Biol Macromol

PubMed ID: 38556234

Doi: 10.1016/j.ijbiomac.2024.131144

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Integrative analysis of metabolism subtypes and identification of prognostic metabolism-related genes for glioblastoma

Authors: Jiahui Li, Yutian Wei, Jiali Liu, Shupeng Cheng, Xia Zhang, Huaide Qiu, Jianan Li, Chuan He

Journal: Biosci Rep

PubMed ID: 38419527

Doi: 10.1042/BSR20231400

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Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy

Authors: Shao-Kang Wang, Xiao-Ting Zhang, Xuan-Yao Jiang, Bi-Jiang Geng, Tao-Lin Qing, Lei Li, Yun Chen, Jin-Feng Li, Xiao-Fang Zhang, Shuo-Gui Xu, Jiang-Bo Zhu, Yu-Ping Zhu, Mei-Tang Wang, Ji-Kuai Chen

Journal: Open Med (Wars)

PubMed ID: 38463518

Doi: 10.1515/med-2024-0898

Products & Services: Proteins, Expression, Isolation and Analysis

Genetically Encoded XTEN-based Hydrogels with Tunable Viscoelasticity and Biodegradability for Injectable Cell Therapies

Authors: Jennifer I Bennett, Mary O'Kelly Boit, Nicole E Gregorio, Fan Zhang, Ryan D Kibler, Jack W Hoye, Olivia Prado, Peter B Rapp, Charles E Murry, Kelly R Stevens, Cole A DeForest

Journal: Adv Sci (Weinh)

PubMed ID: 38477407

Doi: 10.1002/advs.202301708

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Copine proteins are required for brassinosteroid signaling in maize and Arabidopsis

Authors: Teng Jing, Yuying Wu, Yanwen Yu, Jiankun Li, Xiaohuan Mu, Liping Xu, Xi Wang, Guang Qi, Jihua Tang, Daowen Wang, Shuhua Yang, Jian Hua, Mingyue Gou

Journal: Nat Commun

PubMed ID: 38459051

Doi: 10.1038/s41467-024-46289-6

Products & Services: Proteins, Expression, Isolation and Analysis

Discordant Antigenic Properties of Soluble and Virion SARS-CoV-2 Spike Proteins

Authors: Sameer Kumar, Souradip Dasgupta, Mohammad M Sajadi, Greg A Snyder, Anthony L DeVico, Krishanu Ray

Journal: Viruses

PubMed ID: 38543772

Doi: 10.3390/v16030407

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Flublok Quadrivalent Vaccine Adjuvanted with R-DOTAP Elicits a Robust and Multifunctional CD4 T Cell Response That Is of Greater Magnitude and Functional Diversity Than Conventional Adjuvant Systems

Authors: Chantelle L White, Maryah A Glover, Siva K Gandhapudi, Katherine A Richards, Andrea J Sant

Journal: Vaccines (Basel)

PubMed ID: 38543915

Doi: 10.3390/vaccines12030281

Products & Services: Recombinant Proteins

Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform

Authors: Marcal Yll-Pico, Yoonsuh Park, Joy Martinez, Angelina Iniguez, Mindy Kha, Taehyun Kim, Leonard Medrano, Vu H Nguyen, Teodora Kaltcheva, Shannon Dempsey, Flavia Chiuppesi, Felix Wussow, Don J Diamond

Journal: npj Vaccines

PubMed ID: 38555379

Doi: 10.1038/s41541-024-00859-3

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Authors: Yun Bai, Guanghua Cui, Xiaoke Sun, Meiqi Wei, Yanying Liu, Jialu Guo, Yu Yang

Journal: DNA Cell Biol

PubMed ID: 38466955

Doi: 10.1089/dna.2023.0392

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EGFR amplification and EGFRvIII predict and participate in TAT-Cx43266-283 antitumor response in preclinical glioblastoma models

Authors: Andrea Álvarez-Vázquez, Laura San-Segundo, Pilar Cerveró-García, Raquel Flores-Hernández, Claudia Ollauri-Ibáñez, Berta Segura-Collar, C G Hubert, Gillian Morrison, Steven M Pollard, Justin D Lathia, Pilar Sánchez-Gómez, Arantxa Tabernero

Journal: Neuro Oncol

PubMed ID: 38507464

Doi: 10.1093/neuonc/noae060

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Application of Recombinant Lactic Acid Bacteria (LAB) Live Vector Oral Vaccine in the Prevention of F4+ Enterotoxigenic

Authors: Jiangxu Yu, Jiyang Fu, Hongshuo Liu, Chao Kang, Zesong Wang, Yancheng Jin, Shuxuan Wu, Tianzhi Li, Ruicheng Yang, Meilin Jin, Huanchun Chen, Xiangru Wang

Journal: Vaccines (Basel)

PubMed ID: 38543938

Doi: 10.3390/vaccines12030304

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Engineering a Lactobacillus Lysine Riboswitch to Dynamically Control Metabolic Pathways for Lysine Production in

Authors: Qingwei Jiang, Feng Geng, Juan Shen, Ping Zhu, Zhaoxin Lu, Libang Zhou, Fengxia Lu

Journal: Microorganisms

PubMed ID: 38543657

Doi: 10.3390/microorganisms12030606

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Boosting Vaccine Response in Autoimmune Rheumatic Disease Patients With Inadequate Seroconversion: An Analysis of the Immunogenicity of Vector-Based and Inactivated Vaccines

Authors: Anuroopa Vijayan, Aswathy Sukumaran, Sara Jones, Aby Paul, Sakir Ahmed, Pankti Mehta, Manju Mohanan, Santhosh Kumar, Sreekumar Easwaran, Padmanabha Shenoy

Journal: Cureus

PubMed ID: 38586774

Doi: 10.7759/cureus.55764

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Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis

Authors: Xiao-Feng Chen, Yuan-Yuan Duan, Ying-Ying Jia, Qian-Hua Dong, Wei Shi, Yan Zhang, Shan-Shan Dong, Meng Li, Zhongbo Liu, Fei Chen, Xiao-Ting Huang, Ruo-Han Hao, Dong-Li Zhu, Rui-Hua Jing, Yan Guo, Tie-Lin Yang

Journal: Cell Genom

PubMed ID: 38335956

Doi: 1016/j.xgen.2024.100501

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piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis

Authors: Huan Wei, Jie Gao, Di-Hang Lin, Ruirong Geng, Jiaoyang Liao, Tian-Yu Huang, Guanyi Shang, Jiongjie Jing, Zong-Wei Fan, Duo Pan, Zi-Qi Yin, Tianming Li, Xinyu Liu, Shuang Zhao, Chen Chen, Jinsong Li, Xin Wang, Deqiang Ding, Mo-Fang Liu

Journal: Nat Commun

PubMed ID: 38491008

Doi: 10.1038/s41467-024-46664-3

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Influence of Mutations and N-Glycosylation Sites in the Receptor-Binding Domain (RBD) and the Membrane Protein of SARS-CoV-2 Variants of Concern on Antibody Binding in ELISA

Authors: Mandy Schwarze, Daniela Volke, Juan Camilo Rojas Echeverri, Robin Schick, Nicole Lakowa, Thomas Grünewald, Johannes Wolf, Stephan Borte, Markus Scholz, Andor Krizsan, Ralf Hoffmann

Journal: Biology (Basel)

PubMed ID: 38666819

Doi: 10.3390/biology13040207

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Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins

Authors: Simonne Griffith-Jones, Lucía Álvarez, Urbi Mukhopadhyay, Sarah Gharbi, Mandy Rettel, Michael Adams, Janosch Hennig, Sagar Bhogaraju

Journal: EMBO J

PubMed ID: 38448672

Doi: 10.1038/s44318-024-00058-9

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Saikosaponin d protects pancreatic acinar cells against cerulein-induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS-STING pathway

Authors: Hui Chen, Xirong Lu, Beiqi Xu, Gang Cheng, Yuyi Li, Dan Xie

Journal: J Appl Toxicol

PubMed ID: 38462915

Doi: 10.1002/jat.4594

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Construction by artificial intelligence and immunovalidation of hypoallergenic mite allergen Der f 36 vaccine

Authors: Qiao-Zhi Qin, Jian Tang, Cai-Yun Wang, Zhi-Qiang Xu, Man Tian

Journal: Front Immunol

PubMed ID: 38601166

Doi: 10.3389/fimmu.2024.1325998

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Identification of mA RNA methylation genes in and expression profiling in response to different developmental and environmental stimuli

Authors: Mahbub Hasan, Zakia Sultana Nishat, Md Soyib Hasan, Tanvir Hossain, Ajit Ghosh

Journal: Biochem Biophys Rep

PubMed ID: 38511186

Doi: 10.1016/j.bbrep.2024.101677

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Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP

Authors: Avnika A Ruparelia, Margo Montandon, Jo Merriner, Cheng Huang, Siew Fen Lisa Wong, Carmen Sonntag, Justin P Hardee, Gordon S Lynch, Lee B Miles, Ashley Siegel, Thomas E Hall, Ralf B Schittenhelm, Peter D Currie

Journal: JCI Insight

PubMed ID: 38530354

Doi: 10.1172/jci.insight.167578

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Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases

Authors: Friederike Oltmanns, Ana Vieira Antão, Pascal Irrgang, Vera Viherlehto, Leticia Jörg, Anna Schmidt, Jannik T Wagner, Michael Rückert, Ann-Sophie Flohr, Carol Imanuel Geppert, Benjamin Frey, Wibke Bayer, Claudia Gravekamp, Matthias Tenbusch, Udo Gaipl, Dennis Lapuente

Journal: J Immunother Cancer

PubMed ID: 38458636

Doi: 10.1136/jitc-2023-008652

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A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav22 channels and utility in neuropathic pain

Authors: Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris

Journal: Biomed Pharmacother

PubMed ID: 38531121

Doi: 10.1016/j.biopha.2024.116472

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Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients

Authors: Tianming Wang, Min Gong, Yingfei Lu, Chengcheng Zhao, Ling Ling, Jianquan Chen, Rong Ju

Journal: Cell Death Discov

PubMed ID: 38472192

Doi: 10.1038/s41420-024-01899-3

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4'--MethylbavachalconeB Targeted 14-3-3ζ Blocking the Integrin β3 Early Outside-In Signal to Inhibit Platelet Aggregation and Thrombosis

Authors: Ziqi Tang, Fanqi Lin, Zhiwen Chen, Boyang Yu, Ji-Hua Liu, Xiufeng Liu

Journal: J Agric Food Chem

PubMed ID: 38509000

Doi: 10.1021/acs.jafc.3c05211

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Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress

Authors: Yaqin Chai, Xing Gu, HongJun Zhang, Xinting Xu, Lizhan Chen

Journal: Aging (Albany NY)

PubMed ID: 38517365

Doi: 10.18632/aging.205468

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Antibody targeting of surface P-selectin glycoprotein ligand 1 leads to lymphoma apoptosis and tumorigenesis inhibition

Authors: João L Pereira, Francisca Ferreira, Nuno R Dos Santos

Journal: Hematol Oncol

PubMed ID: 38415859

Doi: 10.1002/hon.3257

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The replication phenotype of hepatitis B virus (HBV) splice variants Sp3 and Sp9 and their impact on wild-type HBV replication

Authors: Laura C McCoullough, Tomas Sadauskas, Vitina Sozzi, Kai Yan Mak, Hugh Mason, Margaret Littlejohn, Peter A Revill

Journal: J Virol

PubMed ID: 38501924

Doi: 10.1128/jvi.01538-23

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A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results

Authors: Amy R Rappaport, Chrisann Kyi, Monica Lane, Meghan G Hart, Melissa L Johnson, Brian S Henick, Chih-Yi Liao, Amit Mahipal, Ardaman Shergill, Alexander I Spira, Jonathan W Goldman, Ciaran D Scallan, Desiree Schenk, Christine D Palmer, Matthew J Davis, Sonia Kounlavouth, Lindsey Kemp, Aaron Yang, Yaojun John Li, Molly Likes, Annie Shen, Gregory R Boucher, Milana Egorova, Robert L Veres, J Aaron Espinosa, Jason R Jaroslavsky, Lauren D Kraemer Tardif, Lindsey Acrebuche, Christopher Puccia, Leiliane Sousa, Rita Zhou, Kyounghwa Bae, J Randolph Hecht, David P Carbone, Benny Johnson, Andrew Allen, Andrew R Ferguson, Karin Jooss

Journal: Nat Med

PubMed ID: 38538867

Doi: 10.1038/s41591-024-02851-9

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Long-term effects of Omicron BA2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study

Authors: Yanhua Li, Shijie Qin, Lei Dong, Shitong Qiao, Xiao Wang, Dongshan Yu, Pengyue Gao, Yali Hou, Shouzhen Quan, Ying Li, Fengyan Fan, Xin Zhao, Yueyun Ma, George Fu Gao

Journal: Nat Commun

PubMed ID: 38503738

Doi: 10.1038/s41467-024-46692-z

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CIRP increases Foxp3 regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis

Authors: Zongsheng Wu, Xu Liu, Wei Huang, Jing Chen, Songli Li, Jie Chao, Jianfeng Xie, Ling Liu, Yi Yang, Xiaojing Wu, Haibo Qiu

Journal: Int Immunopharmacol

PubMed ID: 38531201

Doi: 10.1016/j.intimp.2024.111924

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Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity

Authors: Lucy Rutten, Maarten Swart, Annemart Koornneef, Pascale Bouchier, Sven Blokland, Ava Sadi, Jarek Juraszek, Aneesh Vijayan, Sonja Schmit-Tillemans, Johan Verspuij, Ying Choi, Chenandly E Daal, Aditya Perkasa, Shessy Torres Morales, Sebenzile K Myeni, Marjolein Kikkert, Jeroen Tolboom, Daniëlle van Manen, Harmjan Kuipers, Hanneke Schuitemaker, Roland Zahn, Johannes P M Langedijk

Journal: Sci Rep

PubMed ID: 38459086

Doi: 10.1038/s41598-024-56293-x

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YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells

Authors: Shu Li, Xing Li, Yong-Bin Yang, Su-Fang Wu

Journal: Apoptosis

PubMed ID: 38553612

Doi: 10.1007/s10495-023-01935-0

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Development of a colloidal gold immunochromatographic strip for rapid detection of avian coronavirus infectious bronchitis virus

Authors: Chang-Run Zhao, Li-Ting Lin, Jin-Wen Tang, Yu Zhang, Wen Zhang, Ji-Ming Chen, Ping Wei, Teng Huang, Tian-Chao Wei, Mei-Lan Mo

Journal: Poult Sci

PubMed ID: 38574460

Doi: 10.1016/j.psj.2024.103648.

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Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia

Authors: Xuehan Dou, Zhongyuan Chen, Yunzhang Liu, Yun Li, Junli Ye, Ling Lu

Journal: Life Sci

PubMed ID: 38492922

Doi: 10.1016/j.lfs.2024.122564

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Novel PLCZ1 mutation caused polyspermy during in vitro fertilization

Authors: Ke-Ya Tong, Wei-Wei Liu, Li-Wei Sun, Dong-Yun Liu, Ye-Zhou Xiang, Chong Li, Lu-Wei Chai, Ke Chen, Guo-Ning Huang, Jing-Yu Li

Journal: Asian J Androl

PubMed ID: 38445955

Doi: 10.4103/aja202376

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A common protein C inhibitor exosite partially controls the heparin induced activation and inhibition of serine proteases

Authors: Urfi Siddiqui, Abdul Burhan Khan, Tahif Ahmad, Ahmed Abdur Rehman, Mohamad Aman Jairajpuri

Journal: Int J Biol Macromol

PubMed ID: 38521329

Doi: 10.1016/j.ijbiomac.2024.131065

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OsWRKY78 regulates panicle exsertion via gibberellin signaling pathway in rice

Authors: Enyang Mei, Mingliang He, Min Xu, Jiaqi Tang, Jiali Liu, Yingxiang Liu, Zhipeng Hong, Xiufeng Li, Zhenyu Wang, Qingjie Guan, Xiaojie Tian, Qingyun Bu

Journal: J Integr Plant Biol

PubMed ID: 38470298

Doi: 10.1111/jipb.13636

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Study on the Thermal Stability of the Sweet-Tasting Protein Brazzein Based on Its Structure-Sweetness Relationship

Authors: Jingnan Zuo, Wei Zheng, Nian Shi, Rong Song, Fei Han, Chen Yang, Jingwen Li, Chao Peng, Bin Li, Yijie Chen

Journal: J Agric Food Chem

PubMed ID: 38526016

Doi: 10.1021/acs.jafc.3c09616

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Involvement of TGFBI-TAGLN axis in cancer stem cell property of head and neck squamous cell carcinoma

Authors: Motoharu Sarubo, Yasuhiro Mouri, Akira Moromizato, Azusa Yamada, Shengjan Jin, Wenhua Shao, Hiroko Hagita, Keiko Miyoshi, Yasusei Kudo

Journal: Sci Rep

PubMed ID: 38514830

Doi: 10.1038/s41598-024-57478-0

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AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation

Authors: Eva Källberg, Meliha Mehmeti-Ajradini, Frida Björk Gunnarsdottir, Marcus Göransson, Caroline Bergenfelz, Roni Allaoui Fredriksson, Catharina Hagerling, Martin E Johansson, Charlotte Welinder, Karin Jirström, Karin Leandersson

Journal: J Leukoc Biol

PubMed ID: 38060995

Doi: 10.1093/jleuko/qiad152

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Biochemical and structural analysis of N-myristoyltransferase mediated protein tagging

Authors: Paul Monassa , Frédéric Rivière , Cyril Dian , Frédéric Frottin , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230587

Doi: 10.1016/bs.mie.2023.02.016

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Kinetic and catalytic features of N-myristoyltransferases

Authors: Frédéric Rivière , Paul Monassa , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230588

Doi: 10.1016/bs.mie.2023.02.018

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ARGLU1 enhances promoter-proximal pausing of RNA polymerase II and stimulates DNA damage repair

Authors: Scott Bachus, Nikolas Akkerman, Lauren Fulham, Drayson Graves, Rafe Helwer, Jordan Rempel, Peter Pelka

Journal: Nucleic Acids Research

PubMed ID: 38520408

Doi: 10.1093/nar/gkae208

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DNA fragility at topologically associated domain boundaries is promoted by alternative DNA secondary structure and topoisomerase II activity

Authors: Heather M Raimer Young, Pei-Chi Hou, Anna R Bartosik, Naomi D Atkin, Lixin Wang, Zhenjia Wang, Aakrosh Ratan, Chongzhi Zang, Yuh-Hwa Wang

Journal: Nucleic Acids Research

PubMed ID: 38452213

Doi: 10.1093/nar/gkae164

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MiR-326 sponges TET2 triggering imbalance of Th17/Treg differentiation to exacerbate pyroptosis of hepatocytes in concanavalin A-induced autoimmune hepatitis

Authors: Genglin Zhang, Sensen Wu, Guangtao Xia

Journal: Hepatology

PubMed ID: 38043702

Doi: 10.1016/j.aohep.2023.101183

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Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology

Authors: Brendan Miller, Su-Jeong Kim, Kevin Cao, Hemal H Mehta, Neehar Thumaty, Hiroshi Kumagai, Tomomitsu Iida, Cassandra McGill, Christian J Pike, Kamila Nurmakova, Zachary A Levine, Patrick M Sullivan, Kelvin Yen, Nilüfer Ertekin-Taner, Gil Atzmon, Nir Barzilai, Pinchas Cohen

Journal: Cell

PubMed ID: 38520065

Doi: 10.1111/acel.14153

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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Authors: Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters

Journal: Nature

PubMed ID: 38509117

Doi: 10.1038/s41467-024-46644-7

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Haemolysins are essential to the pathogenicity of deep-sea Vibrio fluvialis

Authors: Yujian Wang, Jingchang Luo, Yan Zhao, Jian Zhang, Xiaolu Guan, Li Sun

Journal: iScience

PubMed ID: 38650982

Doi: 10.1016/j.isci.2024.109558

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Proteins containing photosynthetic reaction centre domains modulate FtsZ-based archaeal cell division

Authors: Phillip Nußbaum, Danguole Kureisaite-Ciziene, Dom Bellini, Chris van der Does, Marko Kojic, Najwa Taib, Anna Yeates, Maxime Tourte, Simonetta Gribaldo, Martin Loose, Jan Löwe, Sonja-Verena Albers

Journal: Nat Microbiol

PubMed ID: 38443575

Doi: 10.1038/s41564-024-01600-5

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Structural insights into the Clp protein degradation machinery

Authors: Xiaolong Xu, Yanhui Wang, Wei Huang, Danyang Li, Zixin Deng, Feng Long

Journal: MBio

PubMed ID: 38501868

Doi: 10.1128/mbio.00031-24

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