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Enhancement of SARS-CoV-2 mRNA Vaccine Efficacy through the Application of TMSB10 UTR for Superior Antigen Presentation and Immune Activation

Authors: Xiaoyan Ding, Yuxin Zhou, Jiuxiang He, Jing Zhao, Jintao Li

Journal: Vaccines (Basel)

PubMed ID: 38675814

Doi: 10.3390/vaccines12040432

Products & Services: Molecular Biology Reagents

Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex

Authors: Duc Minh Nguyen, Deanna H Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, Douglas A Kuntz, Maha U Q Mian, Neil C Pomroy, Alexander F A Keszei, Samir Benlekbir, Mohammad T Mazhab-Jafari, John L Rubinstein, Terence E Hébert, Gilbert G Privé

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38625940

Doi: 10.1073/pnas.2315018121

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Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform

Authors: Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart

Journal: Nat Commun

PubMed ID: 38678031

Doi: 10.1038/s41467-024-47795-3

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A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage

Authors: Ting Li, Ning Ding, Hanqing Guo, Rui Hua, Zehao Lin, Huohuan Tian, Yue Yu, Daiming Fan, Zuyi Yuan, Frank J Gonzalez, Yue Wu

Journal: Cell Host & Microbe

PubMed ID: 38237593

Doi: 10.1016/j.chom.2023.12.015

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Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

Authors: Yu Zhuang , Shengjie Jiang , Xiaoling Deng , An Lao , Xiaolin Hua , Yun Xie , Lingyong Jiang , Xudong Wang , Kaili Lin

Journal: SCIENCE ADVANCES

PubMed ID: 38608014

Doi: 10.1126/sciadv.adl0372

Products & Services: Proteins, Expression, Isolation and Analysis

Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters

Authors: Zhi-Hui Yang 1, Yan-Li Song 1, Jie Pei 1, Song-Zhuang Li 1, Rui-Lun Liu 1, Yu Xiong 1, Jie Wu 1, Yuan-Lang Liu 1, Hui-Fen Fan 1, Jia-Hui Wu 1, Ze-Jun Wang 1, Jing Guo 1, Sheng-Li Meng 1, Xiao-Qi Chen 1, Jia Lu 1, Shuo Shen 1

Journal: Viruses

PubMed ID: 38675901

Doi: 10.3390/v16040559

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Kirigami-inspired artificial spidroin microneedles for wound patches

Authors: Yongji Xiong, Yue Xu, Baoyang Lin, Bingfang He, Bingbing Gao

Journal: Int J Biol Macromol

PubMed ID: 38663709

Doi: 10.1016/j.ijbiomac.2024.131838

Products & Services: Proteins, Expression, Isolation and Analysis

The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition

Authors: Bethany J Bogan, Holly C Williams, Claire M Holden, Vraj Patel, Giji Joseph, Christopher Fierro, Hugo Sepulveda, W Robert Taylor, Amir Rezvan, Alejandra San Martin

Journal: Cells

PubMed ID: 38667273

Doi: 10.3390/cells13080658

Products & Services: Proteins, Expression, Isolation and Analysis

Identification, Expression and Evolutional Analysis of Two Genes in Amphioxus

Authors: Yajun Wang, Jingyuan Lin, Wenjin Li, Guangdong Ji, Zhenhui Liu

Journal: Animals (Basel)

PubMed ID: 38672288

Doi: 10.3390/ani14081140

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A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2

Authors: Lalita Mohan Behera, Pulkit Kr Gupta, Manaswini Ghosh, Sucharita Shadangi, Soumendra Rana

Journal: J Phys Chem B

PubMed ID: 38657271

Doi: 10.1021/acs.jpcb.4c00241

Products & Services: Proteins, Expression, Isolation and Analysis

Hypoxic dental pulp stem cells-released succinate promotes osteoclastogenesis and root resorption

Authors: Andi Yang, Jinmeng Wang, Zhiyu Yang, Lulu Wang, Houxuan Li, Lang Lei

Journal: Int J Med Sci

PubMed ID: 38774749

Doi: 10.7150/ijms.94972

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Identification of IGF2 promotes skin wound healing by co-expression analysis

Authors: Xingyan Liu, Ying Teng, Huan Li, Ding Luo, Hongkun Li, Jinghan Shen, Simin Du, Yuyue Zhang, Dali Wang, Jie Jing

Journal: Int Wound J

PubMed ID: 38572823

Doi: 10.1111/iwj.14862

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Unlocking the distinctive enzymatic functions of the early plant biomass deconstructive genes in a brown rot fungus by cell-free protein expression

Authors: Jesus D Castaño, Irina V El Khoury, Joshua Goering, James E Evans, Jiwei Zhang

Journal: Appl Environ Microbiol

PubMed ID: 38567954

Doi: 10.1128/aem.00122-24

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Establishment and application of a gold nanoparticle-based immunochromatographic test strip for the detection of avian leukosis virus P27 antigen in egg white samples

Authors: Chunhao Wei, Hua Kuang, Xinxin Xu, Lingling Guo, Aihua Qu, Aihong Wu, Chuanlai Xu, Liqiang Liu

Journal: Analyst

PubMed ID: 38563739

Doi: 10.1039/d4an00180j

Products & Services: Proteins, Expression, Isolation and Analysis

Heterogeneous and Cooperative Rupture of Histidine-Ni Metal-Coordination Bonds on Rationally Designed Protein Templates

Authors: Eesha Khare, Constancio Gonzalez Obeso, Zaira Martín-Moldes, Ayesha Talib, David L Kaplan, Niels Holten-Andersen, Kerstin G Blank, Markus J Buehler

Journal: ACS Biomater Sci Eng

PubMed ID: 38669114

Doi: 10.1021/acsbiomaterials.3c01819

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Identification and characterization of emGalaseE, a β-1,4 galactosidase from Elizabethkingia meningoseptica, and its application on living cell surface

Authors: Yongliang Tong, Xinrong Lu, Danfeng Shen, Lin Rao, Lin Zou, Shaoxian Lyu, Linlin Hou, Guiqin Sun, Li Chen

Journal: Biological Macromolecules

PubMed ID: 38657932

Doi: 10.1016/j.ijbiomac.2024.131766

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Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing

Authors: Yan He, Xibin Zhou, Chong Chang, Ge Chen, Weikuan Liu, Geng Li, Xiaoqi Fan, Mingsun Sun, Chensi Miao, Qianyue Huang, Yunqing Ma, Fajie Yuan, Xing Chang

Journal: Mol Cell

PubMed ID: 38377993

Doi: 10.1016/j.molcel.2024.01.021

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A rational designed multi-epitope vaccine elicited robust protective efficacy against Klebsiella pneumoniae lung infection

Authors: Jingwen Liao, Xiaoli Zhang, Xi Zeng, Zhuo Zhao, Tianjun Sun, Zhenping Xia, Haiming Jing, Yue Yuan, Zhifu Chen, Qiang Gou, Liqun Zhao, Weijun Zhang, Quanming Zou, Jinyong Zhang

Journal: Biomed Pharmacother

PubMed ID: 38643540

Doi: 10.1016/j.biopha.2024.116611

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Characterization of an O-Specific Glycosyltransferase Involved in Flagellin Glycosylation

Authors: Daisuke Fujinami, Ayumi Mizui, Azusa Miyata, Sohei Ito

Journal: ACS Chem Biol

PubMed ID: 38562012

Doi: 10.1021/acschembio.4c00045

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Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters

Authors: Krishna D Reddy, Burha Rasool, Farideh Badichi Akher, Nemanja Kutlešić, Swati Pant, Olga Boudker

Journal: biorxiv

PubMed ID: 38106174

Doi: 10.1101/2023.12.03.569786

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Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo

Authors: Cheng Siang Tan, Madinah Adrus, Sultana Parvin Habeebur Rahman, Haziq Izzuddin Muhamad Azman, Riz Anasthasia Alta Abang

Journal: BMC Vet Res

PubMed ID: 38678268

Doi: 10.1186/s12917-024-03892-5

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The impact of glycosylation on the structure, function, and interactions of CD14

Authors: Jon Imanol Quintana, Sandra Delgado, Miriam Rábano, Mikel Azkargorta, Mirane Florencio-Zabaleta, Luca Unione, Maria dM Vivanco, Félix Elortza, Jesús Jiménez-Barbero, Ana Ardá

Journal: Glycobiology

PubMed ID: 38227775

Doi: 10.1093/glycob/cwae002

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FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection

Authors: Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Liu

Journal: Signal Transduct Target Ther

PubMed ID: 38654010

Doi: 10.1038/s41392-024-01790-8

Products & Services: Proteins, Expression, Isolation and Analysis

Protocol to identify flavonoid antagonists of the SARS-CoV-2 main protease

Authors: Moua Yang, Lin Lin, Robert Flaumenhaft

Journal: STAR Protoc

PubMed ID: 38583157

Doi: 10.1016/j.xpro.2024.102990

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic-Immune Combination Therapy for Colorectal Cancer

Authors: Lu-Yi Ye, Yi-Shu Li, Tong Ge, Long-Cai Liu, Jing-Xing Si, Xue Yang, Wei-Jiao Fan, Xiao-Zhen Liu, You-Ni Zhang, Jun-Wei Wang, Shi-Bing Wang, Hai Zou, Yue-Liang Zheng, Ke-Tao Jin, Zheng-Wei Mao, Yu Cai, Xiao-Zhou Mou

Journal: Adv Healthc Mater

PubMed ID: 38551143

Doi: 10.1002/adhm.202304136

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The Y locus encodes a REPRESSOR OF PHOTOSYNTHETIC GENES protein that represses carotenoid biosynthesis via interaction with APRR2 in carrot

Authors: Ying-Gang Wang, Yu-Min Zhang, Ya-Hui Wang, Kai Zhang, Jing Ma, Jia-Xin Hang, Yu-Ting Su, Shan-Shan Tan, Hui Liu, Ai-Sheng Xiong, Zhi-Sheng Xu

Journal: Plant Cell

PubMed ID: 38593056

Doi: 10.1093/plcell/koae111

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Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses

Authors: Xuechao Tang, Sufen Li, Jinzhu Zhou, Xianyu Bian, Jianxin Wang, Nan Han, Xuejiao Zhu, Ran Tao, Wei Wang, Min Sun, Peng Li, Xuehan Zhang, Bin Li

Journal: J Virol

PubMed ID: 38591886

Doi: 10.1128/jvi.00212-24

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Proteolytic cleavage of the TGFβ co-receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell membrane

Authors: Kathrine Tejlgård Jensen, Nadia Sukusu Nielsen, Ana Viana Almeida, Ida B Thøgersen, Jan J Enghild, Seandean Lykke Harwood

Journal: FEBS J

PubMed ID: 38587194

Doi: 10.1111/febs.17128

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Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson's disease brains

Authors: Florian Ermini, Victoria F Low, Jennifer J Song, Adelie Y S Tan, Richard L M Faull, Michael Dragunow, Maurice A Curtis, Stephen S Dominy

Journal: NPJ Parkinsons Dis

PubMed ID: 38664405

Doi: 10.1038/s41531-024-00705-2

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A highly efficient blocking ELISA based on p72 monoclonal antibody for the detection of African swine fever virus antibodies and identification of its linear B cell epitope

Authors: Weldu Tesfagaber, Wan Wang, Lulu Wang, Rui Zhao, Yuanmao Zhu, Fang Li, Encheng Sun, Renqiang Liu, Zhigao Bu, Geng Meng, Dongming Zhao

Journal: Int J Biol Macromol

PubMed ID: 38642684

Doi: 10.1016/j.ijbiomac.2024.131695

Products & Services: Recombinant Proteins

Histone derived antimicrobial peptides identified from Mytilus coruscus serum by peptidomics

Authors: Haodong Wang, Zhi Liao, Zongxin Yang, Wenhui Xiao, Zilin Yang, Jianyu He, Xiaolin Zhang, Xiaojun Yan, Changsheng Tang

Journal: Fish Shellfish Immunol

PubMed ID: 38614412

Doi: 10.1016/j.fsi.2024.109546

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MEF2C contributes to axonal branching by regulating Kif2c transcription

Authors: Ronghua Wu, Ying Sun, Zhihao Zhou, Zhangji Dong, Yan Liu, Mei Liu, Huasong Gao

Journal: Eur J Neurosci

PubMed ID: 38663879

Doi: 10.1111/ejn.16344

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Water-deficit stress induces prenylated stilbenoid production and affects biomass in peanut hairy roots: Exploring the role of stilbenoid prenyltransferase downregulation

Authors: Gaurav Gajurel, Rokib Hasan, Fabricio Medina-Bolivar

Journal: Plant Physiol Biochem

PubMed ID: 38579541

Doi: 10.1016/j.plaphy.2024.108596

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RBM3 enhances the stability of MEF2C mRNA and modulates blood-brain barrier permeability in AD microenvironment

Authors: Ye Ding, Meiqing Lin, Jirui Wang, Xiuli Shang

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38670534

Doi: 10.1016/j.bbamcr.2024.119738

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Identification of a circulating three-miRNA panel for the diagnosis of primary open angle glaucoma

Authors: Bo Qin, Li-Ping Li, Qing-Dan Xu, Yuan Lei, Yu-Hong Chen

Journal: Int Ophthalmol

PubMed ID: 38619629

Doi: 10.1007/s10792-024-03100-1

Products & Services: Proteins, Expression, Isolation and Analysis

YeeD is an essential partner for YeeE-mediated thiosulfate uptake in bacteria and regulates thiosulfate ion decomposition

Authors: Mai Ikei, Ryoji Miyazaki, Keigo Monden, Yusuke Naito, Azusa Takeuchi, Yutaro S Takahashi, Yoshiki Tanaka, Keina Murata, Takaharu Mori, Muneyoshi Ichikawa, Tomoya Tsukazaki

Journal: PLoS Biol

PubMed ID: 38656967

Doi: 10.1371/journal.pbio.3002601

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Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation

Authors: Nathan Gf Leborgne, Christelle Devisme, Nedim Kozarac, Inês Berenguer Veiga, Nadine Ebert, Aurélie Godel, Llorenç Grau-Roma, Melanie Scherer, Philippe Plattet, Volker Thiel, Gert Zimmer, Adriano Taddeo, Charaf Benarafa

Journal: JCI Insight

PubMed ID: 38470488

Doi: 10.1172/jci.insight.174133

Products & Services: Proteins, Expression, Isolation and Analysis

Photodynamic therapy upregulates expression of HIF-1α and PD-L1 in related pathways and its clinical relevance in non-small-cell lung cancer

Authors: Wen Sun, Yuan Cheng, Xiaoyu Ma, Zhou Jin, Qi Zhang, Guangfa Wang

Journal: Eur J Med Res

PubMed ID: 38609977

Doi: 10.1186/s40001-024-01780-0

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Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene and in qingke

Authors: Likun An, Ziao Wang, Yongmei Cui, Youhua Yao, Yixiong Bai, Yuehai Liu, Xin Li, Xiaohua Yao, Kunlun Wu

Journal: Open Life Sci

PubMed ID: 38681731

Doi: 10.1515/biol-2022-0855

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Identification of distinct immune signatures in inclusion body myositis by peripheral blood immunophenotyping using machine learning models

Authors: Emily McLeish, Anuradha Sooda, Nataliya Slater, Kelly Beer, Ian Cooper, Frank L Mastaglia, Merrilee Needham, Jerome D Coudert

Journal: Clin Transl Immunology

PubMed ID: 38585335

Doi: 10.1002/cti2.1504

Products & Services: Proteins, Expression, Isolation and Analysis

Lipopolysaccharide modification enhances the inhibitory effect of clodronate liposomes on hepatic fibrosis by depletion of macrophages and hepatic stellate cells

Authors: Luyao Zhang, Min Tao, Hengyan Zhang, Shichao Zhang, Xiaojuan Hou, Chen Zong, Gangqi Sun, Shiyao Feng, Haixin Yan, Ying Lu, Xue Yang, Lixin Wei, Li Zhang

Journal: Chem Biol Interact

PubMed ID: 38663797

Doi: 10.1016/j.cbi.2024.111015

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Significant but partial lipoprotein lipase functional loss caused by a novel occurrence of rare LPL biallelic variants

Authors: Yuepeng Hu, Jian-Min Chen, Han Zuo, Na Pu, Guofu Zhang, Yichen Duan, Gang Li, Zhihui Tong, Weiqin Li, Baiqiang Li, Qi Yang

Journal: Lipids Health Dis

PubMed ID: 38561841

Doi: 10.1186/s12944-024-02086-0

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Diverse Class 2 CRISPR Effectors as Active Nucleases with Expanded Targeting Capabilities

Authors: Meng Wang, Lila Rieber, Jessica van Baaren, Meaghan Morgan, Stephanie Merrett, Ian McDowell, Tyson Bowen

Journal: CRISPR J

PubMed ID: 38635326

Doi: 10.1089/crispr.2023.0058

Products & Services: Codon Optimization

Identification of Enhanced Vaccine Mimotopes for the p15E Murine Cancer Antigen

Authors: Shiqi Zhou, Yiting Song, Yuan Luo, Breandan Quinn, Yang Jiao, Mark D Long, Scott I Abrams, Jonathan F Lovell

Journal: Cancer Res Commun

PubMed ID: 38506662

Doi: 10.1158/2767-9764.CRC-23-0384

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Metal-Binding Protein TaGlo1 Improves Fungal Resistance to Arsenite (As) and Methylarsenite (MAs) in Paddy Soil

Authors: Lijuan Li, Jian Tian, Ke Huang, Ximei Xue, Jian Chen, Feifei Guan, Tuo Zhang, Yifei Sun, Chao He, Xibai Zeng, Shiming Su

Journal: Environ Sci Technol

PubMed ID: 38557082

Doi: 10.1021/acs.est.3c11043

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Engineering, structure, and immunogenicity of a Crimean-Congo hemorrhagic fever virus pre-fusion heterotrimeric glycoprotein complex

Authors: Elizabeth McFadden, Stephanie R Monticelli, Albert Wang, Ajit R Ramamohan, Thomas G Batchelor, Ana I Kuehne, Russell R Bakken, Alexandra L Tse, Kartik Chandran, Andrew S Herbert, Jason S McLellan

Journal: biorxiv

PubMed ID: 38659837

Doi: 10.1101/2024.04.20.590419

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Interaction of ubiquitin-like protein SILENCING DEFECTIVE 2 with LIKE HETEROCHROMATIN PROTEIN 1 is required for regulation of anthocyanin biosynthesis in Arabidopsis thaliana in response to sucrose

Authors: Zhiyi Zhang, Chengcheng Liang, Yulong Ren, Zhaojun Lv, Jirong Huang

Journal: New Phytol

PubMed ID: 38558017

Doi: 10.1111/nph.19725

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RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

Authors: Xian Du, Wenying Qin, Chunyu Yang, Lin Dai, Mingkui San, Yingdan Xia, Siyu Zhou, Mengyang Wang, Shuang Wu, Shaorui Zhang, Huiting Zhou, Fangshu Li, Fang He, Jingfeng Tang, Jia-Yu Chen, Yu Zhou, Rui Xiao

Journal: Genome Biology

PubMed ID: 38641822

Doi: 10.1186/s13059-024-03242-6

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Structural basis for dimerization of a paramyxovirus polymerase complex

Authors: Jin Xie, Mohamed Ouizougun-Oubari, Li Wang, Guanglei Zhai, Daitze Wu, Zhaohu Lin, Manfu Wang, Barbara Ludeke, Xiaodong Yan, Tobias Nilsson, Lu Gao, Xinyi Huang, Rachel Fearns, Shuai Chen

Journal: Nature Communications

PubMed ID: 38605025

Doi: 10.1038/s41467-024-47470-7

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Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1

Authors: Bin Li, Wen-Wu Bai, Tao Guo, Zhen-Yu Tang, Xue-Jiao Jing, Ti-Chao Shan, Sen Yin, Ying Li, Fu Wang, Mo-Li Zhu, Jun-Xiu Lu, Yong-Ping Bai, Bo Dong, Peng Li, Shuang-Xi Wang

Journal: Nat Commun

PubMed ID: 38580662

Doi: 10.1038/s41467-024-47327-z

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Fuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae

Authors: San Hadži, Zala Živič , Matic Kovačič , Uroš Zavrtanik , Sarah Haeserts, Daniel Charlier, Janez Plavec, Alexander N Volkov, Jurij Lah, Remy Loris

Journal: Nature Communications

PubMed ID: 38600130

Doi: 10.1038/s41467-024-47296-3

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Transcription bodies regulate gene expression by sequestering CDK9

Authors: Martino Ugolini, Maciej A Kerlin, Ksenia Kuznetsova, Haruka Oda, Hiroshi Kimura, Nadine L Vastenhouw

Journal: Nature Cell Biology

PubMed ID: 38589534

Doi: 10.1038/s41556-024-01389-9

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Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice

Authors: Jie Dong, Lingkai Kong, Shiqun Wang, Mao Xia, Yenan Zhang, Jingyi Wu, Fuming Yang, Shuguang Zuo, Jiwu Wei

Journal: Experimental & Clinical Cancer Research

PubMed ID: 38566092

Doi: 10.1186/s13046-024-03011-0

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The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis

Authors: Victor E Cruz, Christine S Weirich, Nagesh Peddada, Jan P Erzberger

Journal: Nat Commun

PubMed ID: 38632236

Doi: 10.1038/s41467-024-47616-7

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Authors: Stephane Ferretti, Jacques Hamon, Ruben de Kanter, Clemens Scheufler，Henrik Möbitz, Marta Cortés-Cros

Journal: Nature

PubMed ID: 38658754

Doi: 10.1038/s41586-024-07350-y

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SARS-CoV-2 nsp15 preferentially degrades AU-rich dsRNA via its dsRNA nickase activity

Authors: Xionglue Wang, Bin Zhu

Journal: Nucleic Acids Res

PubMed ID: 38634805

Doi: 10.1093/nar/gkae290

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CRISPR/CasΦ2-mediated gene editing in wheat and rye

Authors: Sanzeng Zhao , Xueying Han , Yachen Zhu , Yuwei Han , Huiyun Liu , Zhen Chen , Huifang Li , Dan Wang , Chaofan Tian , Yuting Yuan , Yajie Guo , Xiaomin Si , Daowen Wang, Xiang Ji

Journal: J Integr Plant Biol

PubMed ID: 38351739

Doi: 10.1111/jipb.13624

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Biomolecular investigations into BBI reveal an enzymatic mechanism for PUFA isomerisation in bifidobacterium CFA bioconversion strains

Authors: Yongchao Mei, Lulu Chang, Yibin Ji, Bo Yang, Jianxin Zhao, Haiqin Chen, Wei Chen

Journal: Int J Biol Macromol

PubMed ID: 38692553

Doi: 10.1016/j.ijbiomac.2024.131836

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Identification and affinity enhancement of T-cell receptor targeting a KRAS cancer neoantigen

Authors: Mengyu Zhang, Wei Xu, Lingjie Luo, Fenghui Guan, Xiangyao Wang, Pei Zhu, Jianhua Zhang, Xuyu Zhou, Feng Wang, Sheng Ye

Journal: Commun Biol

PubMed ID: 38684865

Doi: 10.1038/s42003-024-06209-2

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Artificial Extracellular Vesicles Generated from T Cells Using Different Induction Techniques

Authors: Ekaterina A Zmievskaya, Sabir A Mukhametshin, Irina A Ganeeva, Elvina M Gilyazova, Elvira T Siraeva, Marianna P Kutyreva, Artur A Khannanov, Youyong Yuan, Emil R Bulatov

Journal: Biomedicines

PubMed ID: 38672273

Doi: 10.3390/biomedicines12040919

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Safe plant Hsp90 adjuvants elicit an effective immune response against SARS-CoV2-derived RBD antigen

Authors: Victor A Ramos-Duarte, Alejandro Orlowski, Carolina Jaquenod de Giusti, Mariana G Corigliano, Ariel Legarralde, Luisa F Mendoza-Morales, Agustín Atela, Manuel A Sánchez, Valeria A Sander, Sergio O Angel, Marina Clemente

Journal: Vaccine

PubMed ID: 38631949

Doi: 10.1016/j.vaccine.2024.04.036

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Chitosan-LeoA-DNA Nanoparticles Promoted the Efficacy of Novel LeoA-DNA Vaccination on Mice Against Helicobacter pylori

Authors: Zahra Ahmadzadeh Chaleshtori, Ali Asghar Rastegari, Hashem Nayeri, Abbas Doosti

Journal: Curr Microbiol

PubMed ID: 38558085

Doi: 10.1007/s00284-024-03642-8

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High mobility group box 1 mediates inflammatory responses in malignant peritoneal mesothelioma

Authors: Lianfen Wang, Xuesong Wang, Ningning Sun, Weili Liu

Journal: Int Immunopharmacol

PubMed ID: 38613884

Doi: 10.1016/j.intimp.2024.112039

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Saccharomyces cerevisiae cellular engineering for the production of FAME biodiesel

Authors: Laiyou Wang, Bingbing Liu, Qingshan Meng, Chunchun Yang, Yiyi Hu, Chunyan Wang, Pengyu Wu, Chen Ruan, Wenhuan Li, Shuang Cheng, Shuxian Guo

Journal: AMB Express

PubMed ID: 38658521

Doi: 10.1186/s13568-024-01702-7

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LINC02605 involved in paediatric Mycoplasma pneumoniae pneumonia complicated with diarrhoea via miR-539-5p/CXCL1 axis

Authors: Yang Zhang, Zeming Wu

Journal: Eur J Clin Invest

PubMed ID: 38662581

Doi: 10.1111/eci.14234

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Structural basis of human Na15 gating mechanisms

Authors: Krishna Chinthalapudi, Rupam Biswas, Ana López-Serrano, Hsiang-Ling Huang, Angelina Ramirez-Navarro, Giovanna Grandinetti, Sarah Heissler, Isabelle Deschênes

Journal: Res Sq

PubMed ID: 38659812

Doi: 10.21203/rs.3.rs-3985999/v1

Products & Services: Molecular Biology Reagents

The miR184-3p targets neuron-specific ecdysone inducible protein 78 to promote rice black streaked dwarf virus propagation in its planthopper vector

Authors: Haitao Wang, Yan Dong, Man Wang, Shuo Li, Yijun Zhou, Yinghua Ji

Journal: Pest Manag Sci

PubMed ID: 38676556

Doi: 10.1002/ps.8150

Products & Services: Proteins, Expression, Isolation and Analysis

Precision miRNA profiling: Electrochemiluminescence powered by CRISPR-Cas13a and hybridization chain reaction

Authors: Jihua Wei, Jiayi Zhang, Wei Wang, Haidong Zhou, Huade Ma, Yuanxun Gong, Qianli Tang, Kai Zhang, Xianjiu Liao

Journal: Anal Chim Acta

PubMed ID: 38719418

Doi: 10.1016/j.aca.2024.342641

Products & Services: DNA Sequencing

Barley yellow dwarf virus-GAV 17K protein disrupts thiamine biosynthesis to facilitate viral infection in plants

Authors: Xiaoyu Han, Xue Yang, Siyu Chen, He Wang, Xiaomin Liu, Daowen Wang, Jin Yang, Linlin Chen, Bingjian Sun, Honglian Li, Yan Shi

Journal: Plant J

PubMed ID: 38635415

Doi: 10.1111/tpj.16772

Products & Services: Proteins, Expression, Isolation and Analysis

Multiplexed gene editing in citrus by using a multi-intron containing Cas9 gene

Authors: Poulami Sarkar, Jorge Santiago Vazquez, Mingxi Zhou, Amit Levy, Zhonglin Mou, Vladimir Orbović

Journal: Transgenic Res

PubMed ID: 38564120

Doi: 10.1007/s11248-024-00380-2

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Authors: Kristen A Baltgalvis, Kelsey N Lamb, Kent T Symons, Chu-Chiao Wu, Melissa A Hoffman, Aaron N Snead, Xiaodan Song, Thomas Glaza, Shota Kikuchi, Jason C Green, Donald C Rogness, Betty Lam, Maria E Rodriguez-Aguirre, David R Woody, Christie L Eissler, Socorro Rodiles, Seth M Negron, Steffen M Bernard, Eileen Tran, Jonathan Pollock, Ali Tabatabaei, Victor Contreras, Heather N Williams, Martha K Pastuszka, John J Sigler, Piergiorgio Pettazzoni, Markus G Rudolph, Moritz Classen, Doris Brugger, Christopher Claiborne, Jean-Marc Plancher, Isabel Cuartas, Joan Seoane, Laurence E Burgess, Robert T Abraham, David S Weinstein, Gabriel M Simon, Matthew P Patricelli, Todd M Kinsella

Journal: Nature

PubMed ID: 38658751

Doi: 10.1038/s41586-024-07318-y

Products & Services: Recombinant Proteins

MSC-derived small extracellular vesicles mitigate diabetic retinopathy by stabilizing Nrf2 through miR-143-3p-mediated inhibition of neddylation

Authors: Yueqin Chen, Jun Tong, Cong Liu, Chang He, Jinjin Xiang, Genhong Yao, Huayong Zhang, Zhenggao Xie

Journal: Free Radic Biol Med

PubMed ID: 38604315

Doi: 10.1016/j.freeradbiomed.2024.04.216

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Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity

Authors: Vikas Tiwari, Paras Gupta, Navya Malladi, Sanjay Salgar, Sanjay K Banerjee

Journal: Free Radic Biol Med

PubMed ID: 38582228

Doi: 10.1016/j.freeradbiomed.2024.04.212

Products & Services: ORF cDNA Clones/MolecularCloud

Bioactive fiber-reinforced hydrogel to tailor cell microenvironment for structural and functional regeneration of myotendinous junction

Authors: Yuzhi Sun 1, Renwang Sheng 2, Zhicheng Cao 1, Chuanquan Liu 2, Jiaxiang Li 1, Po Zhang 1, Yan Du 2, Qingyun Mo 2, Qingqiang Yao 1 3, Jialin Chen 2 3 4, Wei Zhang 2 3 4

Journal: Sci Adv

PubMed ID: 38657071

Doi: 10.1126/sciadv.adm7164

Products & Services: Recombinant Proteins

The Transpeptidase Sortase A Binds Nucleic Acids and Mediates Mammalian Cell Labeling

Authors: Yingzheng Liu, Zhike Lu, Panfeng Wu, Zhaohui Liang, Zhenxing Yu, Ke Ni, Lijia Ma

Journal: Adv Sci (Weinh)

PubMed ID: 38581131

Doi: 10.1002/advs.202305605

Products & Services: Proteins, Expression, Isolation and Analysis

IGFBP1a is a nutrient deficient response factor that can inhibit fish reproduction through the hypothalamus-pituitary-ovary axis†

Authors: Wei Li, Hangyu Li, Qiongyao Hu, Linlin Wang, Zhan Yin, Guangfu Hu

Journal: Biol Reprod

PubMed ID: 38374691

Doi: 10.1093/biolre/ioae009

Products & Services: Gene Synthesis

Effector enrichment by Candidatus Liberibacter promotes Diaphorina citri feeding via Jasmonic acid pathway suppression

Authors: Hao Liu, Bin Deng, Feng-Hao Chen, Jia-Qi Suo, Ge-Cheng Ouyang, Hui-Lin Lu, Da-Song Chen, Xiang Meng

Journal: Pest Manag Sci

PubMed ID: 38554028

Doi: 10.1002/ps.8107

Products & Services: Proteins, Expression, Isolation and Analysis

Exploring immune evasion of SARS-CoV-2 variants using a pseudotyped system

Authors: Haixiao Duan, Ershuai Zhang, Ge Ren, Yining Cheng, Binfeng Yang, Lirong Liu, Normand Jolicoeur, Han Hu, Yan Xu, Binlei Liu

Journal: Heliyon

PubMed ID: 38699727

Doi: 10.1016/j.heliyon.2024.e29939

Products & Services: Gene Synthesis

Application of Cas12j for Editing

Authors: Lee Ling Tan, Elena Heng, Chung Yan Leong, Veronica Ng, Lay Kien Yang, Deborah Chwee San Seow, Lokanand Koduru, Yoganathan Kanagasundaram, Siew Bee Ng, Guangrong Peh, Yee Hwee Lim, Fong Tian Wong

Journal: Biomolecules

PubMed ID: 38672502

Doi: 10.3390/biom14040486

Products & Services: Gene Synthesis

Remodeling the Homologous Recombination Mechanism of for High-Level Biosynthesis of Squalene

Authors: Man Xu, Nan Yang, Jiang Pan, Qiang Hua, Chun-Xiu Li, Jian-He Xu

Journal: J Agric Food Chem

PubMed ID: 38635942

Doi: 10.1021/acs.jafc.4c01779

Products & Services: Gene Synthesis

Roles of a newly lethal cuticular structural protein, AaCPR100A, and its upstream interaction protein, G12-like, in Aedes aegypti

Authors: Jing Chen, Yuchen Wu, Jiukai Chen, Haoran Lu, Gong Cheng, Zhijian Jake Tu, Chenghong Liao, Qian Han

Journal: Int J Biol Macromol

PubMed ID: 38670198

Doi: 10.1016/j.ijbiomac.2024.131704

Products & Services: Proteins, Expression, Isolation and Analysis

CRISPR Screen Identifies the RNA-Binding Protein Eef1a1 as a Key Regulator of Myogenesis

Authors: Weiwei Liu, Wei Wang, Zishuai Wang, Xinhao Fan, Wangchang Li, Yuxin Huang, Xiaogan Yang, Zhonglin Tang

Journal: Int J Mol Sci

PubMed ID: 38732031

Doi: 10.3390/ijms25094816

Products & Services: Custom DNA/RNA Oligos

Co-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis

Authors: Yue Wang, Yatu Peng, Guanghui Zi, Jin Chen, Baowei Peng

Journal: Sci Rep

PubMed ID: 38582932

Doi: 10.1038/s41598-024-58765-6

Products & Services: Proteins, Expression, Isolation and Analysis

Functionalizing Yeast Lipid Droplets as Versatile Biomaterials

Authors: Ankita Suri, Kevin K Y Hu, Tayyaba Younas, Geoff Dumsday, Victoria S Haritos

Journal: Small

PubMed ID: 38566530

Doi: 10.1002/smll.202308463

Products & Services: Proteins, Expression, Isolation and Analysis

Broadly neutralizing antibodies against emerging delta-coronaviruses

Authors: Megi Rexhepaj, Young-Jun Park, Lisa Perruzza, Daniel Asarnow, Mathew Mccallum, Katja Culap, Christian Saliba, Giada Leoni, Alessio Balmelli, Courtney N Yoshiyama, Miles S Dickinson, Joel Quispe, Jack Taylor Brown, M Alejandra Tortorici, Kaitlin R Sprouse, Ashley L Taylor, Tyler N Starr, Davide Corti, Fabio Benigni, David Veesler

Journal: biorxiv

PubMed ID: 38617231

Doi: 10.1101/2024.03.27.586411

Products & Services: Proteins, Expression, Isolation and Analysis

Unveiling orphan receptor-like kinases in plants: novel client discovery using high-confidence library predictions in the Kinase-Client (KiC) assay

Authors: Gabriel Lemes Jorge, Daewon Kim, Chunhui Xu, Sung-Hwan Cho, Lingtao Su, Dong Xu, Laura E Bartley, Gary Stacey, Jay J Thelen

Journal: Front Plant Sci

PubMed ID: 38633461

Doi: 10.3389/fpls.2024.1372361

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Dietary Hemin Remodels Gut Microbiota and Mediates Tissue Inflammation and Injury in the Small Intestine

Authors: Qian Li, Weixin Ke, Shuai Jiang, Miao Zhang, Kai Shan, Chunbao Li

Journal: Mol Nutr Food Res

PubMed ID: 38676468

Doi: 10.1002/mnfr.202300889

Products & Services: Molecular Biology Reagents

Development and characterization of a bacterial enzyme cascade reaction system for efficient and stable PET degradation

Authors: Chengyong Wang, Rui Long, Xiran Lin, Wei Liu, Liying Zhu, Ling Jiang

Journal: J Hazard Mater

PubMed ID: 38703683

Doi: 10.1016/j.jhazmat.2024.134480

Products & Services: Molecular Biology Reagents

Exploring the substrate spectrum of phylogenetically distinct bacterial polyesterases

Authors: Konstantinos Makryniotis, Efstratios Nikolaivits, George Taxeidis, Jasmina Nikodinovic-Runic, Evangelos Topakas

Journal: Biotechnol J

PubMed ID: 38593303

Doi: 10.1002/biot.202400053

Products & Services: Molecular Biology Reagents

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR

Authors: Gregory Zilberg, Alexandra K Parpounas, Audrey L Warren, Bianca Fiorillo, Davide Provasi, Marta Filizola, Daniel Wacker

Journal: SCIENCE ADVANCES

PubMed ID: 37986777

Doi: 10.1101/2023.10.05.561100

Products & Services: Proteins, Expression, Isolation and Analysis

CoCas9 is a compact nuclease from the human microbiome for efficient and precise genome editing

Authors: Eleonora Pedrazzoli, Michele Demozzi, Elisabetta Visentin, Matteo Ciciani, Ilaria Bonuzzi, Laura Pezzè, Lorenzo Lucchetta, Giulia Maule, Simone Amistadi, Federica Esposito, Mariangela Lupo, Annarita Miccio, Alberto Auricchio, Antonio Casini, Nicola Segata, Anna Cereseto

Journal: Nat Commun

PubMed ID: 38658578

Doi: 10.1038/s41467-024-47800-9

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system

Authors: Poppy Datta, Kun Do Rhee, Rylee J Staudt, Jacob M Thompson, Ying Hsu, Salma Hassan, Arlene V Drack, Seongjin Seo

Journal: Human Molecular Genetics

PubMed ID: 38645107

Doi: 10.1101/2024.04.10.588864

Products & Services: PCR and Cloning ORF cDNA Clones/MolecularCloud

Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy

Authors: Madison A Ward, Janakiram R Vangala, Hatem Elif Kamber Kaya, Holly A Byers, Nayyerehalsadat Hosseini, Antonio Diaz, Ana Maria Cuervo, Susmita Kaushik, Senthil K Radhakrishnan

Journal: J Cell Biol

PubMed ID: 38656405

Doi: 10.1083/jcb.202306150

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Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis

Authors: Xinran Wang, Ningxin Chen, Pablo Cruz-Morales, Biming Zhong, Yangming Zhang, Jian Wang, Yifan Xiao, Xinnan Fu, Yang Lin, Suneil Acharya, Zhibo Li, Huaxiang Deng, Yuhui Sun, Linquan Bai, Xiaoyu Tang, Jay D Keasling, Xiaozhou Luo

Journal: Nat Metab

PubMed ID: 38609677

Doi: 10.1038/s42255-024-01024-9

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Pharmacology of PACAP and VIP receptors in the spinal cord highlights the importance of the PAC receptor

Authors: Zoe Tasma, Tayla A Rees, Song Guo, Sheryl Tan, Simon J O'Carroll, Richard L M Faull, Maurice A Curtis, Sarah L Christensen, Debbie L Hay, Christopher S Walker

Journal: Br J Pharmacol

PubMed ID: 38616050

Doi: 10.1111/bph.16376

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibition of USP7 enhances CD8 T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation

Authors: Lin-Lin Sun, Li-Na Zhao, Jiao Sun, Hong-Feng Yuan, Yu-Fei Wang, Chun-Yu Hou, Pan Lv, Hui-Hui Zhang, Guang Yang, Ning-Ning Zhang, Xiao-Dong Zhang, Wei Lu

Journal: Acta Pharmacol Sin

PubMed ID: 38589688

Doi: 10.1038/s41401-024-01263-2

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Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling

Authors: Luca Unione, Augustinus N A Ammerlaan, Gerlof P Bosman, Elif Uslu, Ruonan Liang, Frederik Broszeit, Roosmarijn van der Woude, Yanyan Liu, Shengzhou Ma, Lin Liu, Marcos Gómez-Redondo, Iris A Bermejo, Pablo Valverde, Tammo Diercks, Ana Ardá, Robert P de Vries, Geert-Jan Boons

Journal: Nat Commun

PubMed ID: 38582892

Doi: 10.1038/s41467-024-47344-y

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Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis

Authors: Yu Jeong Choi, Yoonjung Kim, Hye Jung Park, Dokyun Kim, Hyukmin Lee, Young Ah Kim, Kyung-A Lee

Journal: Ann Clin Microbiol Antimicrob

PubMed ID: 38581051

Doi: 10.1186/s12941-024-00687-2

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Generation and characterization of a nanobody against the avian influenza virus H7 subtype

Authors: Xiuqin Huang, Weiye Li, Xuewei Cao, Qi Zhang, Yizhen Lin, Siqi Xu, Xinying Dong, Peiqi Liu, Yutong Liu, Ge He, Kaijian Luo, Saixiang Feng

Journal: Int J Biol Macromol

PubMed ID: 38593899

Doi: 10.1016/j.ijbiomac.2024.131458

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Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity

Authors: André Nguyen Dietzsch, Hadi Al-Hasani, Joachim Altschmied, Katharina Bottermann, Jana Brendler, Judith Haendeler, Susanne Horn, Isabell Kaczmarek, Antje Körner, Kerstin Krause, Kathrin Landgraf, Diana Le Duc, Laura Lehmann, Stefan Lehr, Stephanie Pick, Albert Ricken, Rene Schnorr, Angela Schulz, Martina Strnadová, Akhil Velluva, Heba Zabri, Torsten Schöneberg, Doreen Thor, Simone Prömel

Journal: Signal Transduct Target Ther

PubMed ID: 38664368

Doi: 10.1038/s41392-024-01810-7

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