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ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activity

Authors: Andrew E Becker, Paweł Kochanowski, Pui-Kei Wu, Elżbieta Wątor, Wenjing Chen, Koushik Guchhait, Artur P Biela, Przemysław Grudnik, Jong-In Park

Journal: Cell Reports

PubMed ID: 39392755

Doi: 10.1016/j.celrep.2024.114831

Products & Services: Gene Synthesis

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition

Authors: Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A Rogers, Dale L Ludwig, Rohini Dwivedi, Franziska Bleichert, Peter M Glazer

Journal: Oncotarget

PubMed ID: 39352803

Doi: 10.18632/oncotarget.28651

Products & Services: Mammalian Expression Custom mRNA synthesis

Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168

Authors: Huasong Ai , Zebin Tong , Zhiheng Deng , Qiang Shi, Shixian Tao , Gaoge Sun, Jiawei Liang , Maoshen Sun , Xiangwei Wu , Qingyun Zheng , Lujun Liang , Hang Yin , Jia-Bin Li , Shuai Gao , Changlin Tian , Lei Liu , Man Pan

Journal: Nature Chemical Biology

PubMed ID: 39394267

Doi: doi.org/10.1038/s41589-024-01750-x

Products & Services: Gene Synthesis Molecular Biology Reagents

Natural SNP Variation in GbOSM1 Promotor Enhances Verticillium Wilt Resistance in Cotton

Authors: Guilin Wang, Dayong Zhang , Haitang Wang , Jinmin Kong , Zhiguo Chen , Chaofeng Ruan , Chaoyang Deng , Qihang Zheng , Zhan Guo , Hanqiao Liu, Weixi Li , Xinyu Wang , Wangzhen Guo

Journal: Advanced Science

PubMed ID: 39413014

Doi: 10.1002/advs.202406522

Products & Services: Protein and Antibody Isolation

4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice

Authors: Rahul V G , Govindaraj Ellur , Amir A Gaber , Prem Kumar Govindappa , John C Elfar

Journal: Cell Death Discov

PubMed ID: 39366954

Doi: 10.1038/s41420-024-02199-6

Products & Services: Protein and Antibody Isolation

Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control

Authors: Carlos R Detrés Román, Megan M Erwin, Michael W Rudloff, Frank Revetta, Kristen A Murray, Natalie R Favret, Jessica J Roetman, Joseph T Roland, Mary K Washington, Mary Philip

Journal: J Immunother Cancer

PubMed ID: 39362791

Doi: 10.1136/jitc-2024-009129

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Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans

Authors: Yabin Hu, Qian Wu, Fangfang Chang, Jing Yang, Xiaoyue Zhang, Qijie Wang, Jun Chen, Shishan Teng, Yongchen Liu, Xingyu Zheng, You Wang, Rui Lu, Dong Pan, Zhanpeng Liu, Fen Liu, Tianyi Xie, Chanfeng Wu, Yinggen Tang, Fei Tang, Jun Qian, Hongying Chen, Wenpei Liu, Yi-Ping Li, Xiaowang Qu

Journal: npj Vaccines

PubMed ID: 39438493

Doi: 10.1038/s41541-024-00997-8

Products & Services: Gene Synthesis

Gegen Qinlian Decoction reverses oxaliplatin resistance in colorectal cancer by inhibiting YTHDF1-regulated m6A modification of GLS1

Authors: Xiang Lin , Li Xu , Meng Gu , Huan Shao , Li Yao , Xuan Huang

Journal: Phytomedicine

PubMed ID: 39089089

Doi: 10.1016/j.phymed.2024.155906

Products & Services: Protein Electrophoresis and Western

Far-red light photoacclimation in a desert Chroococcidiopsis strain with a reduced FaRLiP gene cluster and expression of its chlorophyll f synthase in space-resistant isolates

Authors: Giorgia di Stefano, Mariano Battistuzzi, Nicoletta La Rocca, Vera M Selinger, Dennis J Nürnberg, Daniela Billi

Journal: Frontiers in Microbiology

PubMed ID: 39328908

Doi: 10.3389/fmicb.2024.1450575

Products & Services: Gene Synthesis

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket

Authors: Johannes Morstein , Victoria Bowcut , Micah Fernando , Yue Yang , Lawrence Zhu , Meredith L Jenkins , John T Evans , Keelan Z Guiley , D Matthew Peacock , Sophie Krahnke , Zhi Lin , Katrine A Taran , Benjamin J Huang , Andrew G Stephen , John E Burke , Felice C Lightstone , Kevan M Shokat

Journal: Cell

PubMed ID: 39255801

Doi: 10.1016/j.cell.2024.08.017

Products & Services: DNA Sequencing

Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases

Authors: Jiacheng Deng,† , Xueyuan Li,† , Hao Yu,† , Lin Yang1, Ziru Wang1, Wenfeng Yi, Ying Liu, Wenyu Xiao, Hongyong Xiang, Zicong Xie, Dongmei Lv, Hongsheng Ouyang, Daxin Pang, * and Hongming Yuan

Journal: Nucleic Acids Research

PubMed ID: 39271120

Doi: doi.org/10.1093/nar/gkae800

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Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71

Authors: Rong-Rong Zhang 1, Meng-Jiao He 1, Chao Zhou 1, Yan-Peng Xu 1, Wei Tang 1, Tian-Shu Cao 1, Zheng-Jian Wang , Mei Wu , Tao Ming , Yi-Jiao Huang , Meng-Xu Sun , Hui Zhao , Yong-Qiang Deng , Xiao-Feng Li , Bin Wang , Qing Ye , Cheng-Feng Qin

Journal: VIROLOGICA SINICA

PubMed ID: 39306193

Doi: 10.1016/j.virs.2024.09.008

Products & Services: Peptide Tools

Crystal structure and nucleic acid binding mode of CPV NSP9: implications for viroplasm in Reovirales

Authors: Yeda Wang , Hangtian Guo , Yuhao Lu , Wanbin Yang , Tinghan Li , Xiaoyun Ji

Journal: Nucleic Acids Research

PubMed ID: 39287123

Doi: doi.org/10.1093/nar/gkae803

Products & Services: Gene Synthesis

Efficient circularization of protein-encoding RNAs via a novel cis-splicing system

Authors: Shaojun Qi , Huiming Wang , Guopeng Liu , Qianshan Qin , Peng Gao , Bo Ying

Journal: Nucleic Acids Research

PubMed ID: 39162233

Doi: 10.1093/nar/gkae711

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Intein splicing efficiency and RadA levels can control the mode of archaeal DNA replication

Authors: Geraldy L S Liman , Christopher W Lennon , Jaylin L Mandley , Alina M Galyon , Kelly M Zatopek , Andrew F Gardner , Thomas J Santangelo

Journal: SCIENCE ADVANCES

PubMed ID: 39292776

Doi: 10.1126/sciadv.adp4995

Products & Services: Gene Synthesis Mutagenesis Services

Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression

Authors: Haley E Adcox , Jason R Hunt , Paige E Allen , Thomas E Siff , Kyle G Rodino , Andrew K Ottens , Jason A Carlyon

Journal: Nature Communications

PubMed ID: 39277599

Doi: 10.1038/s41467-024-52119-6

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In Situ Noninvasive Monitoring of Cell Secretions Based on MOFs/AAO Hybrid Membrane Induced Asymmetric Ion Transport

Authors: Zhaohan Wang , Yafeng Wu , Zhi Wang , Zhaoyan Tian , Yu Liu , Songqin Liu

Journal: Biosensors & bioelectronics

Doi: 10.1016/j.bios.2024.116735

Products & Services: Recombinant Proteins

PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation

Authors: Zhenwei Liang, ∙ Tao Zhu, ∙ Yaoguang Yu,∙ … ∙ Yuhai Cui ∙ Shangzhi Huang ∙ Chenlong Li

Journal: Molecular Cell

Doi: doi.org/10.1016/j.molcel.2024.08.018

Products & Services: Molecular Biology Reagents

Photoexcited Cryptochrome 1 Interacts With SPCHLESS to Regulate Stomatal Development in Arabidopsis

Authors: Li Chen 1 2, Xiaoli Cao , Yupeng Li 1 2, Minqing Liu 1, Yao Liu 1, Yan Guan 1 2, Jiaqi Ruan 1, Zhilei Mao 1 2, Wenxiu Wang 1 2, Hong-Quan Yang 1 2, Tongtong Guo

Journal: PLANT CELL AND ENVIRONMENT

PubMed ID: 39253954

Doi: 10.1111/pce.15123

Products & Services: Antibody Modification and Purification Services

Inhalation of Bioorthogonal Gene-Editable Spiky-Pollen Reprograms Tumor-Associated Macrophages for Lung Cancer Immunotherapy

Authors: Qianglan Lu , Ruiyue Chen , Fei Zeng, Zhiyong Liu, Yongchun Pan, Yanfeng Gao, Bangshun He and Yujun Song

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202408767

Products & Services: Synthetic Guide RNA

Identification of an RNA-binding perturbing characteristic for thiopurine drugs and their derivatives to disrupt CELF1–RNA interaction

Authors: Yang Tan , Zhibo Zhao , Qingfang Han , Peipei Xu , Xiaopeng Shen , Yajun Jiang , Qiang Xu , Xingxin Wu

Journal: Nucleic Acids Research

PubMed ID: 39268573

Doi: 10.1093/nar/gkae788

Products & Services: Plasmid DNA Preparation

Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice

Authors: Jia He , Chaoyu Wang , Xiao Fang , Junyao Li , Xueying Shen , Junxia Zhang , Cheng Peng , Hongjian Li , Sai Li , Jeffrey M Karp , Rui Kuai

Journal: Nature Communications

PubMed ID: 39284814

Doi: 10.1038/s41467-024-52104-z

Products & Services: Peptide Synthesis

Epitope prime editing shields hematopoietic cells from CD123 immunotherapy for acute myeloid leukemia

Authors: Rui-Jin Ji , Guo-Hua Cao , Wei-Qiang Zhao , Mu-Yao Wang , Pan Gao, Yi-Zhou Zhang, Xue-Bin Wang, Hou-Yuan Qiu , Di-Di Chen, Xiao-Han Tong , Min Duan, Hao Yin, Ying Zhang

Journal: Cell Stem Cell

PubMed ID: 39353428

Doi: 10.1016/j.stem.2024.09.003

Products & Services: Synthetic Guide RNA

Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase

Authors: Elżbieta Wątor, Piotr Wilk, Paweł Kochanowski, Przemysław Grudnik

Journal: FEBS J

Doi: doi.org/10.1111/febs.17207

Products & Services: Gene Synthesis

Pyroptotic-Spatiotemporally Selective Delivery of siRNA against Pyroptosis and Autoimmune Diseases

Authors: Zongyou Pan, Kaiwang Xu, Guanrui Huang, Haoran Hu, Huang Yang, Haotian Shen, Kaijie Qiu, Canlong Wang, Tengjing Xu, Xinning Yu, Jinhua Fang, Jiajie Wang, Yunting Lin, Jiacheng Dai, Yuting Zhong, Hongyun Song, Sunan Zhu, Siheng Wang, Zhuxing Zhou, Chuyue Sun, Zhaopeng Tang, Shiyao Liao, Guang Yang, Zhiyuan You, Xuesong Dai, Zhengwei Mao

Journal: ADVANCED MATERIALS

PubMed ID: 39081086

Doi: 10.1002/adma.202407115

Products & Services: Recombinant Proteins

SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

Authors: Kaixiang Zhu, Lili Song, Linyue Wang, Lei Hua, Ziyu Luo, Tongyun Wang, Bo Qin, Shuofeng Yuan, Xiaopan Gao, Wenyi Mi, Sheng Cui

Journal: Acta Pharmaceutica Sinica B

PubMed ID: 39309499

Doi: doi.org/10.1016/j.apsb.2024.05.018

Products & Services: Gene Synthesis

Mitochondrial rewiring with small-molecule drug-free nanoassemblies unleashes anticancer immunity

Authors: Lulu Ren , Jianqin Wan , Xiaoyan Li , Jie Yao , Yan Ma , Fanchao Meng , Shusen Zheng , Weidong Han , Hangxiang Wang

Journal: Nature Communications

PubMed ID: 39227567

Doi: 10.1038/s41467-024-51945-y

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EXTL3 and NPC1 are mammalian host factors for Autographa californica multiple nucleopolyhedrovirus infection

Authors: Yuege Huang , Hong Mei , Chunchen Deng , Wei Wang , Chao Yuan , Yan Nie , Jia-Da Li , Jia Liu

Journal: Nature Communications

PubMed ID: 39231976

Doi: 10.1038/s41467-024-52193-w

Products & Services: Protein and Antibody Isolation

A bioorthogonal probiotic platform spatiotemporally releases nanobodies in deep tumor for cancer chemoimmunotherapy

Authors: Ruiyue Chen , Qianglan Lu , Fei Zeng , Shurong Qin , Yongchun Pan , Zhiyong Liu , Yuzhen Wang , Bangshun He , Wenjin Qi , Yujun Song

Journal: Materials Today

Doi: 10.1016/j.mattod.2024.09.002

Products & Services: Recombinant Proteins

Rapid generation of long, chemically modified pegRNAs for prime editing

Authors: Xinlin Lei , Anhui Huang , Didi Chen , Xuebin Wang , Ruijin Ji , Jinlin Wang , Yizhou Zhang , Yuming Zhang , Shuhan Lu , Kun Zhang , Qiubing Chen , Ying Zhang , Hao Yin

Journal: Nature Biotechnology

PubMed ID: 39349835

Doi: doi.org/10.1038/s41587-024-02394-x

Products & Services: Custom DNA/RNA Oligos Gene Synthesis Synthetic Guide RNA

Antimony Component Schottky Nanoheterojunctions as UltrasoundHeightened Pyroptosis Initiators for Sonocatalytic Immunotherapy

Authors: Jihu Nie, Nailin Yang , Shumin Sun , Li Wang , Zifan Pei, Jie Wu, Qiao Yu, Zhihui Han ,Youdong Chen , Liang Cheng

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39305135

Doi: 10.1002/anie.202416426

Products & Services: Protein and Antibody Isolation

Open-Source Throttling of CD8+ T Cells in Brain with Low-Intensity Focused Ultrasound-Guided Sequential Delivery of CXCL10, IL-2, and aPD-L1 for Glioblastoma Immunotherapy

Authors: Lei Dong , Yini Zhu , Haoge Zhang , Lin Gao , Zhiqi Zhang , Xiaoxuan Xu , Leqian Ying , Lu Zhang , Yue Li , Zhengcheng Yun , Danqi Zhu , Chang Han , Tingting Xu , Hui Yang , Shenghong Ju , Xiaoyuan Chen , Haijun Zhang , Jinbing Xie

Journal: ADVANCED MATERIALS

PubMed ID: 39264011

Doi: 10.1002/adma.202407235

Products & Services: Recombinant Proteins

Strontium-Modified porous attapulgite composite hydrogel scaffold with advanced angiogenic and osteogenic potential for bone defect repair

Authors: Chun Liu , Su Ni , Xiaoyu Wu , Linxiang Zhang , Ting Dai , Aiqin Wang , Hongbin Zhao

Journal: COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING

Doi: doi.org/10.1016/j.compositesa.2024.108492

Products & Services: Protein Electrophoresis and Western

Identification of antimicrobial bioactive peptides from the camel milk protein lactoferrin: Molecular docking, molecular dynamic simulation, and in vitro study

Authors: Mohammed Alzain , Ehab M.M. Ali , Mazin Zamzami , Ishtiaq Qadri , Hani Choudhry , Kamel Chaieb , Bochra Kouidhi , Hisham N. Altayb

Journal: food and humanity

Doi: doi.org/10.1016/j.foohum.2024.100414

Products & Services: Peptide Synthesis

Diffusiophoresis promotes phase separation and transport of biomolecular condensates

Authors: Viet Sang Doan , Ibraheem Alshareedah , Anurag Singh , Priya R Banerjee , Sangwoo Shin

Journal: Nature Communications

PubMed ID: 37461689

Doi: 10.1038/s41467-024-51840-6

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AntigenBoost: enhanced mRNA-based antigen expression through rational amino acid substitution

Authors: Yumiao Gao, Siran Zhu, Huichun Li, Xueting Hao, Wen Chen, Deng Pan, Zhikang Qian

Journal: BRIEFINGS IN BIOINFORMATICS

PubMed ID: 39400114

Doi: 10.1093/bib/bbae468

Products & Services: Gene Synthesis

Arabidopsis cryptochromes interact with SOG1 to promote the repair of DNA double-strand breaks

Authors: Li Chen , Minqing Liu , Yupeng Li , Yan Guan, Jiaqi Ruan , Zhilei Mao , Wenxiu Wang , Hong-Quan Yang , Tongtong Guo

Journal: BBRC

Doi: 10.1016/j.bbrc.2024.150233

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Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

Authors: Jiachao Xu, Yu Liang, Nan Li, Song Dang, Amin Jiang, Yiqun Liu, Yuting Guo, Xiaoyu Yang, Yi Yuan, Xinyi Zhang, Yaran Yang, Yongtao Du, Anbing Shi, Xiaoyun Liu, Dong Li, Kangmin He

Journal: Nature Cell Biology

PubMed ID: 39300312

Doi: 10.1038/s41556-024-01499-4

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OsGRF6-OsYUCCA1/OsWRKY82 Signaling Cascade Upgrade Grain Yield and Bacterial Blight Resistance in Rice

Authors: Huanran Yuan, Mingxing Cheng, Fengfeng Fan , Xingfei Zheng , Ruihua Wang , Fengfeng Si , Xiong Luo, Nengwu Li 1, Shaoqing Li

Journal: Advanced Science

PubMed ID: 38923395

Doi: 10.1002/advs.202407733

Products & Services: Gene Synthesis

Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes

Authors: Yani Arhab , Tatyana V Pestova , Christopher U T Hellen

Journal: Viruses

PubMed ID: 39339889

Doi: 10.3390/v16091413

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The 8-oxoguanine DNA glycosylase-synaptotagmin 7 pathway increases extracellular vesicle release and promotes tumour metastasis during oxidative stress

Authors: Ying Ma , Jiarong Guo , Haipeng Rao , Jingyu Xin , Xinyi Song , Rui Liu , Shan Shao , Jiajia Hou , Liyu Kong , Zhigang Hu , Lingfeng He , Feiyan Pan , Zhigang Guo

Journal: Journal of extracellular vesicles

PubMed ID: 39235072

Doi: 10.1002/jev2.12505

Products & Services: Gene Synthesis

Chemoproteomic profiling unveils binding and functional diversity of endogenous proteins that interact with endogenous triplex DNA

Authors: Hongzhan Xu , Jing Ye # , Kui-Xing Zhang # , Qingxi Hu , Tongxiao Cui , Chong Tong , Mengqi Wang , Huichao Geng , Kun-Ming Shui , Yan Sun , Jian Wang , Xiaomeng Hou , Kai Zhang , Ran Xie , Yafei Yin , Nan Chen , Jia-Yu Chen

Journal: nature Chemistry

PubMed ID: 39223307

Doi: 10.1038/s41557-024-01609-7

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OsFAD1–OsMYBR22 modulates clustered spikelet through regulating BRD3 in rice

Authors: Mingxing Cheng , Huanran Yuan , Ruihua Wang , Fengfeng Fan , Fengfeng Si , Xiong Luo , Wei Liu , Shaoqing Li

Journal: Journal of integrative plant biology

PubMed ID: 39279451

Doi: doi.org/10.1111/jipb.13775

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Discovery of alkaline laccases from basidiomycete fungi through machine learning-based approach

Authors: Xing Wan, Sazzad Shahrear, Shea Wen Chew, Francisco Vilaplana, Miia R Mäkelä

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 39261970

Doi: 10.1186/s13068-024-02566-6

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A maternal brain hormone that builds bone

Authors: Muriel E Babey, William C Krause, Kun Chen, Candice B Herber, Zsofia Torok, Joni Nikkanen, Ruben Rodriguez, Xiao Zhang, Fernanda Castro-Navarro, Yuting Wang, Erika E Wheeler, Saul Villeda, J Kent Leach, Nancy E Lane, Erica L Scheller, Charles K F Chan, Thomas H Ambrosi, Holly A Ingraham

Journal: Nature

PubMed ID: 38987585

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Preparation of polyclonal antibody against thrombospondin 2 recombinant protein and its functional verification in pulmonary hypertension syndrome in broilers

Authors: Wen Peng, Chenxi Jiang, Gaofeng Cai, Liling Liu, Xiaoquan Guo, Xiaona Gao, Guyue Li, Zhanhong Zheng, Pei Liu, Ping Liu

Journal: International Journal of Biological Macromolecules

PubMed ID: 38906344

Doi: doi.org/10.1016/j.ijbiomac.2024.133284

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Transcription elongation of the plant RNA polymerase IV is prone to backtracking

Authors: Chengli Fang, Kun Huang, Xiaoxian Wu, Hongwei Zhang, Zhanxi Gu, Jiawei Wang, Yu Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 39178250

Doi: 10.1126/sciadv.adq3087

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A two-pronged nanostrategy of iron metabolism disruption to synergize tumor therapy by triggering the paraptosis-apoptosis hybrid pathway

Authors: Huali Lei , Guanghui Hou , Lin Liu , Zifan Pei , Youdong Chen , Yujie Lu , Nalin Yang , Shumin Sun , Liang Cheng

Journal: ACS Nano

PubMed ID: 39121010

Doi: 10.1021/acsnano.4c06199

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25-Hydroxycholesterol inhibits Hantavirus infection by reprogramming cholesterol metabolism

Authors: Yamei Dang , Yuan Wang , Jing Wei , Hui Zhang , Qiqi Yang , Bin Wang , Jia Li , Chuantao Ye , Yang Chen , Peijun Han , Xiaolei Jin , Jia Wang , Xiaohui Bao , He Liu , Hongwei Ma , Liang Zhang , Linfeng Cheng , Yangchao Dong , Yinlan Bai , Yinghui Li , Yingfeng Lei , Zhikai Xu , Fanglin Zhang , Wei Ye

Journal: FREE RADICAL BIOLOGY AND MEDICINE

PubMed ID: 39209137

Doi: 10.1016/j.freeradbiomed.2024.08.029

Products & Services: Codon Optimization

Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus

Authors: Pheonah Badu , Gabriele Baniulyte , Morgan A Sammons , Cara T Pager

Journal: Virology Journal

PubMed ID: 39212382

Doi: 10.1128/jvi.01055-24

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Reduced Cross-Protective Potential of Omicron Compared to Ancestral SARS-CoV-2 Spike Vaccines Against Potentially Zoonotic Coronaviruses

Authors: Tyler RennerMatthew StuibleBrian CassSylvie PerretJulie GuimondSimon Lord-DufourMichael J. McCluskieYves DurocherBassel Akache

Journal: npj Viruses

Doi: doi.org/10.21203/rs.3.rs-4791122/v1

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Proteasome gene expression is controlled by coordinated functions of multiple transcription factors

Authors: Jennifer E Gilda, Asrafun Nahar, Dharanibalan Kasiviswanathan, Nadav Tropp, Tamar Gilinski, Tamar Lahav, Dina Alexandrovich, Yael Mandel-Gutfreund, Soyeon Park, Shenhav Shemer

Journal: J Cell Biol

PubMed ID: 38767572

Doi: 10.1083/jcb.202402046

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A metal anion strategy to induce pyroptosis combined with STING activation to synergistically amplify anti-tumor immunity

Authors: Zifan Pei , Nan Jiang , Fei Gong , Weihao Yang , Jiachen Xu , Bin Yu , Nailin Yang , Jie Wu , Huali Lei , Shumin Sun , Longxiao Li , Zhicheng Liu , Caifang Ni , Liang Cheng

Journal: Materials Today

Doi: 10.1016/j.mattod.2024.07.013

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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

Authors: Cheng Zhang , Hong-Ming Ma , Shuai Wu , Jia-Ming Shen , Na Zhang , Yi-Lu Xu , Cheng-Xiao Li , Ping He , Meng-Kai Ge , Xi-Li Chu , Yu-Xue Zhang , Jun-Ke Zheng , Guo-Qiang Chen , Shao-Ming Shen

Journal: Developmental Cell

PubMed ID: 39197453

Doi: 10.1016/j.devcel.2024.08.003

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Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels

Authors: Yuanyue Shan , Mengmeng Zhang , Meiyu Chen , Xinyi Guo , Ying Li , Mingfeng Zhang , Duanqing Pei

Journal: Nature Communications

PubMed ID: 39209849

Doi: 10.1038/s41467-024-51800-0.

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Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation

Authors: Nicoletta Cieri 1 2 3, Nidhi Hookeri 1 2 4, Kari Stromhaug 1 2, Liang Li 2, Julia Keating 4, Paula Díaz-Fernández 5, Valle Gómez-García de Soria 6, Jonathan Stevens 7, Raphael Kfuri-Rubens 1 2, Yiren Shao 1 2 4, Kameron A Kooshesh 3, Kaila Powell 1, Helen Ji 1, Gabrielle M Hernandez 2, Jennifer Abelin 2, Susan Klaeger 2 8, Cleo Forman 1 4, Karl R Clauser 2, Siranush Sarkizova 2, David A Braun 1 2 3 9 10, Livius Penter 1 2 3 11, Haesook T Kim 4, William J Lane 3 7, Giacomo Oliveira 1 2 3, Leslie S Kean 3 12, Shuqiang Li 1 13, Kenneth J Livak 1 13, Steven A Carr 2, Derin B Keskin 1 2 3 13 14 15, Cecilia Muñoz-Calleja 5 16, Vincent T Ho 1 3 9, Jerome Ritz 1 3 9, Robert J Soiffer 1 3 9, Donna Neuberg 4, Chip Stewart 2, Gad Getz 2 3 17 18, Catherine J Wu 19 20 21 22

Journal: Nat Biotechnol

PubMed ID: 39169264

Doi: 10.1038/s41587-024-02348-3

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Regulation of Glandular Size and Phytoalexin Biosynthesis by a Negative Feedback Loop in Cotton

Authors: Wen-Kai Wu, Gui-Bin Nie, Jia-Ling Lin, Jia-Fa Huang, Xiao-Xiang Guo, Mei Chen, Xin Fang, Ying-Bo Mao, Yan Li, Ling-Jian Wang, Xiao-Yuan Tao, Yiqun Gao, Zuo-Ren Yang, Jin-Quan Huang

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

PubMed ID: 38840438

Doi: 10.1002/advs.202403059. Epub 2024 Jun 5.

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hypocretin-1/hypocretin receptor 1 regulates neuroplasticity and cognitive function through hippocampal lactate homeostasis in depressed model

Authors: Bing Chen , Kangyu Jin , Jingyi Dong , Shangping Cheng , Lingzhuo Kong , Shaohua Hu , Zuobing Chen, Jing Lu

Journal: Advanced Science

PubMed ID: 39119889

Doi: 10.1002/advs.202405354

Products & Services: Protein Electrophoresis and Western Protein Electrophoresis and Western

Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1

Authors: Ying Sui , Ziyang Shen, Xiaoyou Li 1, Ya Lu , SiTong Feng , Rong Ma, Jianzhong Wu , Changwen Jing, Zhuo Wang, Jifeng Feng , Haixia Cao

Journal: Cell death & disease

PubMed ID: 39097608

Doi: 10.038/s41419-024-06941-x

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Spatiotemporal coordination of antigen presentation and co-stimulatory signal for enhanced anti-tumor vaccination

Authors: Sha Peng , Yumeng Yan , Kenji Ogino , Guanghui Ma , Yufei Xia

Journal: Journal of controlled release

PubMed ID: 39153722

Doi: 10.1016/j.jconrel.2024.08.025.

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A low-molecular-weight α-glucan from edible fungus Agaricus blazei Murrill activates macrophage TFEB-mediated antibacterial defense to combat implant-associated infection

Authors: Qishan Wang , Yuehong Wang , Yihao Liu , Kai Yuan , Yixuan Lin , Xian Qian , Hongyan Pei , Liangliang Weng , Kaijian Fan , Yihe Hu , Yiqi Yang

Journal: Carbohydrate Polymers

Doi: 10.1016/j.carbpol.2024.122659

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siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice

Authors: Yi Ding 1, Qiu-Bing Chen , Hui Xu , Dilare Adi , Yi-Wen Ding , Wen-Jun Luo , Wen-Zhuo Zhu , Jia-Chen Xu , Xiaolu Zhao , Xiong-Jie Shi , Jie Luo , Hao Yin , Xiao-Yi Lu

Journal: Journal of lipid research

PubMed ID: 39173829

Doi: 10.1016/j.jlr.2024.100626

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Channelrhodopsins with distinct chromophores and binding patterns

Authors: Yuanyue Shan , Liping Zhao , Meiyu Chen , Xiao Li , Mingfeng Zhang , Duanqing Pei

Journal: Nature Communications

PubMed ID: 39181878

Doi: 10.1038/s41467-024-51811-x

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Anattachment glycoprotein nanoparticle elicits broadly neutralizing antibodies and protects against lethal Nipah virus infection

Authors: Dan Zhou , Rao Cheng , Yanfeng Yao , Gan Zhang , Xin Li , Bingjie Wang , Yong Wang , Feiyang Yu , Shangyu Yang , Hang Liu , Ge Gao , Yun Peng , Miaoyu Chen , Zengqin Deng , Haiyan Zhao

Journal: npj Vaccines

PubMed ID: 39217188

Doi: 10.1038/s41541-024-00954-5

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Human mitochondrial carriers of the SLC25 family function as monomers exchanging substrates with a ping-pong kinetic mechanism

Authors: Camila Cimadamore-Werthein , Martin S King , Denis Lacabanne , Eva Pyrihová , Stephany Jaiquel Baron , Edmund Rs Kunji

Journal: EMBO J

PubMed ID: 38937634

Doi: 10.1038/s44318-024-00150-0.

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Cellular N-Myristoyl Transferases Are Required for Mammarenavirus Multiplication

Authors: Haydar Witwit , Carlos Alberto Betancourt , Beatrice Cubitt , Roaa Khafaji , Heinrich Kowalski , Nathaniel Jackson , Chengjin Ye , Luis Martinez-Sobrido , Juan C de la Torre

Journal: Viruses

PubMed ID: 39339839

Doi: 10.3390/v16091362

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Dynamics and implications of anti-drug antibodies against adalimumab using ultra-sensitive and highly drug-tolerant assays

Authors: Xiaoliang Ding, Ling Xue, Mingjun Wang, Shengxiong Zhu, Kouzhu Zhu, Sheng Jiang, Jian Wu, Liyan Miao

Journal: Frontiers in Immunology

PubMed ID: 39238635

Doi: 10.3389/fimmu.2024.1429544

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A Ubiquitin-Competitive Strategy Based on the Element Microenvironment toTreat Osteoarthritis

Authors: Keyu Kong, Yuqi Yang, Yongyun Chang, Youdong Chen, Xiao Yang, Jiahao Qin, Zhuorun Song, Shunyi Lu, Zanjing Zhai, Jun Ge, Huiwu Li, Liang Cheng

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202409707

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Highly sensitive and selective electrochemical biosensor using odorant-binding protein to detect aldehydes

Authors: Cong Peng a b, Yutong Sui a, Chaohua Fang a, Hongxu Sun a, Wenxin Liu a, Xinying Li a, Chen Qu a, Wenhui Li a, Jiemin Liu a c, Chuandong Wu a

Journal: Analytica Chimica Acta

Doi: 10.1016/j.aca.2024.342932

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CLASP-mediated competitive binding in protein condensates directs microtubule growth

Authors: Xuanyan Jia , Leishu Lin, Siqi Guo , Lulu Zhou , Gaowei Jin , Jiayuan Dong , Jinman Xiao , Xingqiao Xie , Yiming Li , Sicong He , Zhiyi Wei , Cong Yu

Journal: Nature Communications

PubMed ID: 39095354

Doi: 10.1038/s41467-024-50863-3

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Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe

Authors: Yuan Ma , Hui Cao , Baode Chen , Xinyu Xu , Qingpeng Zhang , Haoming Chen , Xiao-Bing Zhang , Guosheng Song

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39115358

Doi: 10.1002/anie.202411840

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A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection

Authors: Xuanxiu Ren # 1, Jiawen Sun # 2 3, Wenhua Kuang # 2, Feiyang Yu 1, Bingjie Wang 1, Yong Wang 2 3, Wei Deng 2 3, Zhao Xu 2 3, Shangyu Yang 1, Hualin Wang 2 4, Yangbo Hu 2 4, Zengqin Deng 5 6, Yun-Jia Ning 7 8, Haiyan Zhao

Journal: Nature Communications

PubMed ID: 39147753

Doi: 10.1038/s41467-024-51108-z

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Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair

Authors: Shiman Zuo , Yuxin Wang , Hanjing Bao , Zehui Zhang , Nanfei Yang , Meng Jia , Qing Zhang , Ani Jian , Rong Ji , Lidan Zhang , Yan Lu , Yahong Huang , Pingping Shen

Journal: Nature Communications

PubMed ID: 39179603

Doi: doi.org/10.1038/s41467-024-51736-5

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Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations

Authors: Sateesh Maddirevula , Mohammad Shagrani , Ae-Ri Ji , Christopher R Horne , Samuel N Young , Lucy J Mather , Mashael Alqahtani , Colin McKerlie , Geoffrey Wood , Paul K Potter , Firdous Abdulwahab , Tarfa AlSheddi , Wendy L van der Woerd , Koen L I van Gassen , Dalal AlBogami , Kishwer Kumar , Ali Syed Muhammad Akhtar , Hiba Binomar , Fowzan S Alkuraya

Journal: GENETICS IN MEDICINE

PubMed ID: 39132680

Doi: 10.1016/j.gim.2024.101231

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A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites

Authors: Dimuthu Angage, Jill Chmielewski, Janesha C Maddumage, Eva Hesping, Sabrina Caiazzo, Keng Heng Lai, Lee Ming Yeoh, Joseph Menassa, D Herbert Opi, Callum Cairns, Hamsa Puthalakath, James G Beeson, Marc Kvansakul, Justin A Boddey, Danny W Wilson, Robin F Anders, Michael Foley

Journal: Nat Commun

PubMed ID: 39174515

Doi: 10.1038/s41467-024-50770-7

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Reversible control of kinase signaling through chemical-induced dephosphorylation

Authors: Ying Sun , Rihong Zhou , Jin Hu , Shan Feng , Qi Hu

Journal: Communications Biology

PubMed ID: 39217250

Doi: 10.1038/s42003-024-06771-9

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Confined Gel-Electromembrane Extraction of Oligonucleotides

Authors: Cong Liu, Jie Liu, Quan Liu, Qianyun Zhu, Hao Wang, Xiangming Fang, Wenfang Zhang, Zilong Liu, Chuixiu Huang

Journal: Analytical Chemistry

PubMed ID: 39078883

Doi: 10.1021/acs.analchem.4c02239

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Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures

Authors: Hongwei Zhang , Zhanxi Gu , Yuan Zeng , Yu Zhang

Journal: Structure

PubMed ID: 38870940

Doi: 10.1016/j.str.2024.05.013

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OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation

Authors: Xiao-Yu Teng , Ping Hu , Cai-Ming Zhang , Qin-Xin Zhang , Guolin Yang , Yan-Yu Zang , Zhi-Xiong Liu , Guiquan Chen , Yun Stone Shi

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 39083419

Doi: 10.1073/pnas.2403652121

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Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions

Authors: Jiexin Li , Ruiqi Yang , Fuqiang Dong , Qian Qiu , Zhen Jiang , He Ren , Chen Zhang , Gengqi Liu , Jonathan F Lovell , Yumiao Zhang

Journal: ACS Nano

PubMed ID: 39109520

Doi: 10.1021/acsnano.3c12375

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Zinc Coordination Lipid Nanoparticles Co-Delivering Calcium Peroxide and Chelating STING agonist for Enhanced Cancer Metalloimmunotherapy

Authors: Qian Qiu , Jiexin Li , He Ren , Jingyu Zhang , Gengqi Liu , Ruiqi Yang , Boyang Sun , Chen Zhang , Yumiao Zhang

Journal: Small

PubMed ID: 39114869

Doi: 10.1002/smll.202402308

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The Effects of the Carrier and Ligand Spatial Conformation on RNA Nanodrug Cell Delivery

Authors: Zhuang Zhang , Siying Li , Hongda Wang , Yuping Shan

Journal: Analytical Chemistry

PubMed ID: 39096242

Doi: 10.1021/acs.analchem.4c02270

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A Minimalist Pathogen-Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy

Authors: Yu Miao , Le Niu , Xinying Lv , Qiang Zhang , Zhisheng Xiao , Zhaoxin Ji , Linfu Chen , Yi Liu , Nanhui Liu , Junjie Zhu , Yang Yang , Qian Chen

Journal: ADVANCED MATERIALS

PubMed ID: 39210649

Doi: 10.1002/adma.202410715

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Peptide degrader-based targeting of METTL3/14 improves immunotherapy response in cutaneous melanoma

Authors: Hong Han , Zenghui Li , Yuqing Feng , He Song , Zhixiong Fang , Dingxiao Zhang , Dan Yuan , Junfeng Shi

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39136347

Doi: doi.org/10.1002/anie.202407381

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Reversibly photoswitchable protein assemblies with collagen affinity for in vivo photoacoustic imaging of tumors

Authors: Shuai Chen , Kaixin Li , Xin Chen , Shan Lei , Jing Lin , Peng Huang

Journal: SCIENCE ADVANCES

PubMed ID: 39213344

Doi: 10.1126/sciadv.adn8274

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The strongest protein binder is surprisingly labile

Authors: Alba Fernandez-Calvo, Antonio Reifs, Laura Saa, Aitziber L Cortajarena, David De Sancho, Raul Perez-Jimenez

Journal: Protein Sci

PubMed ID: 38864696

Doi: 10.1002/pro.5030

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Lytic transglycosylase Slt of Pseudomonas aeruginosa as a periplasmic hub protein

Authors: Luis F Avila-Cobian, Stefania De Benedetti, Hidekazu Hoshino, Van T Nguyen, Amr M El-Araby, Safaa Sader, Daniel D Hu, Sara L Cole, Choon Kim, Jed F Fisher, Matthew M Champion, Shahriar Mobashery

Journal: Protein Sci

PubMed ID: 38864725

Doi: 10.1002/pro.5038

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Efficient Chemical Synthesis of Multi-Monoubiquitylated and Diubiquitylated Histones by the α-Halogen Ketone-Mediated Strategy

Authors: Shuai Peng, Xin Liu, Chengpiao Lu, Haibo Wang, Xiaotong Liu, Qingyue Gong, Huizhong Tao, Hongrui Xu, Changlin Tian, Guoqiang Xu, Jia-Bin Li

Journal: Bioconjugate Chemistry

PubMed ID: 38954775

Doi: 10.1021/acs.bioconjchem.4c00130

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Identification of endothelial protein C receptor as a novel druggable agonistic target for reendothelialization promotion and thrombosis prevention of eluting stent

Authors: Jing Chen , Changyi Zhou , Weilun Fang , Jiasheng Yin , Jian Shi , Junbo Ge , Li Shen , Shi-Ming Liu , Shao-Jun Liu

Journal: Bioactive Materials

Doi: doi.org/10.1016/j.bioactmat.2024.07.028

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Fluorinated Titanium Oxide (TiO2-xFx) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy

Authors: Shumin Sun , Xuan Huang , Nailin Yang , Huali Lei , Zifan Pei , Zhihui Han , Lin Liu , Fei Gong , Qiao Yu , Jingrui Li , Youdong Chen , Liang Cheng

Journal: ACS Nano

PubMed ID: 39010657

Doi: 10.1021/acsnano.4c05448

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Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile

Authors: Everardo R Rodriguez Rodriguez, Rune Thorbjørn Nordvang, Marcus Petersson, Jakob Kræmmer Haar Rendsvig, Emma Wenzel Arendrup, Monica L Fernández Quintero, Timothy P Jenkins, Andreas H Laustsen, Sandra Wingaard Thrane

Journal: Protein Sci

PubMed ID: 38923049

Doi: 10.1002/pro.5035

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Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

Authors: Michael J Peluso, Dylan Ryder, Robert R Flavell, Yingbing Wang, Jelena Levi, Brian H LaFranchi, Tyler-Marie Deveau, Amanda M Buck, Sadie E Munter, Kofi A Asare, Maya Aslam, Walter Koch, Gyula Szabo, Rebecca Hoh, Monika Deswal, Antonio E Rodriguez, Melissa Buitrago, Viva Tai, Uttam Shrestha, Scott Lu, Sarah A Goldberg, Thomas Dalhuisen, Joshua J Vasquez, Matthew S Durstenfeld, Priscilla Y Hsue, J Daniel Kelly, Nitasha Kumar, Jeffrey N Martin, Aruna Gambhir, Ma Somsouk, Youngho Seo, Steven G Deeks, Zoltan G Laszik, Henry F VanBrocklin, Timothy J Henrich

Journal: Sci Transl Med

PubMed ID: 38959327

Doi: 10.1126/scitranslmed.adk3295

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Improvement and application of vacuum-infiltration system in tomato

Authors: Xinghao Yao, Ayat Taheri, Hang Liu, Yaojie Zhang, Ling Li, Jin Shao, Ke Wu, Qing Miao, Weizhi He, Xinyi Hu, Kexuan Tang

Journal: Horticulture research

Doi: doi.org/10.1093/hr/uhae197

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Engineering psychrophilic polymerase for nanopore long-read sequencing

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian

Journal: Front Bioeng Biotechnol

PubMed ID: 39011153

Doi: 10.3389/fbioe.2024.1406722

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Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ

Authors: Souradeep Banerjee, Debojyoti Chowdhury, Soham Chakraborty, Shubhasis Haldar

Journal: Protein Sci

PubMed ID: 38864739

Doi: 10.1002/pro.5068

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Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax

Authors: Yi Cao 1, Clifford T H Hayashi , Maisa da Silva Araujo , Abhai K Tripathi , Alice Oliveira Andrade , Jansen Fernandes Medeiros , Joseph Vinetz & Nirbhay Kumar

Journal: Vaccine

PubMed ID: 39033079

Doi: 10.1016/j.vaccine.2024.07.041

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Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale

Authors: Ruiwen Zhang , Zhou He , Yajing Shi , Xiangkun Sun , Xinyu Chen , Guoquan Wang , Yizhou Zhang , Pan Gao , Ying Wu , Shuhan Lu , Junyi Duan , Shangwu Sun , Na Yang , Wei Fan , Kaitao Zhao , Bei Yang , Yuchen Xia , Yan Zhang , Ying Zhang , Hao Yin

Journal: Cell

PubMed ID: 38936359

Doi: 10.1016/j.cell.2024.05.056

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Mechanisms Ensuring Fidelity of Family X DNA Polymerases in Programmed DNA rearrangements in Paramecium tetraurelia

Authors: Antonin Nourisson, Sophia Missoury, Ahmed Haouz, Marc Delarue

Journal: biorxiv

Doi: 2024.07.26.605286

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Cytochrome b5 diversity in green lineages preceded the evolution of syringyl lignin biosynthesis

Authors: Xianhai Zhao, Yunjun Zhao, Qing-Yin Zeng, Chang-Jun Liu

Journal: Plant Cell

PubMed ID: 38657101

Doi: 10.1093/plcell/koae120

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Optimizing the Design and Geometry of T Cell-Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer

Authors: Abdullah Elsayed, Louis Plüss, Larissa Nideroest, Giulia Rotta, Marina Thoma, Nathan Zangger, Frederik Peissert, Stefanie K Pfister, Christian Pellegrino, Sheila Dakhel Plaza, Roberto De Luca, Markus G Manz, Annette Oxenius, Emanuele Puca, Cornelia Halin, Dario Neri

Journal: Mol Cancer Ther

PubMed ID: 38638035

Doi: 10.1158/1535-7163.MCT-23-0766

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