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4'--MethylbavachalconeB Targeted 14-3-3ζ Blocking the Integrin β3 Early Outside-In Signal to Inhibit Platelet Aggregation and Thrombosis

Authors: Ziqi Tang, Fanqi Lin, Zhiwen Chen, Boyang Yu, Ji-Hua Liu, Xiufeng Liu

Journal: J Agric Food Chem

PubMed ID: 38509000

Doi: 10.1021/acs.jafc.3c05211

Products & Services: Gene Synthesis

Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress

Authors: Yaqin Chai, Xing Gu, HongJun Zhang, Xinting Xu, Lizhan Chen

Journal: Aging (Albany NY)

PubMed ID: 38517365

Doi: 10.18632/aging.205468

Products & Services: Custom DNA/RNA Oligos

Antibody targeting of surface P-selectin glycoprotein ligand 1 leads to lymphoma apoptosis and tumorigenesis inhibition

Authors: João L Pereira, Francisca Ferreira, Nuno R Dos Santos

Journal: Hematol Oncol

PubMed ID: 38415859

Doi: 10.1002/hon.3257

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The replication phenotype of hepatitis B virus (HBV) splice variants Sp3 and Sp9 and their impact on wild-type HBV replication

Authors: Laura C McCoullough, Tomas Sadauskas, Vitina Sozzi, Kai Yan Mak, Hugh Mason, Margaret Littlejohn, Peter A Revill

Journal: J Virol

PubMed ID: 38501924

Doi: 10.1128/jvi.01538-23

Products & Services: Proteins, Expression, Isolation and Analysis

Long-term effects of Omicron BA2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study

Authors: Yanhua Li, Shijie Qin, Lei Dong, Shitong Qiao, Xiao Wang, Dongshan Yu, Pengyue Gao, Yali Hou, Shouzhen Quan, Ying Li, Fengyan Fan, Xin Zhao, Yueyun Ma, George Fu Gao

Journal: Nat Commun

PubMed ID: 38503738

Doi: 10.1038/s41467-024-46692-z

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YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells

Authors: Shu Li, Xing Li, Yong-Bin Yang, Su-Fang Wu

Journal: Apoptosis

PubMed ID: 38553612

Doi: 10.1007/s10495-023-01935-0

Products & Services: Molecular Biology Reagents

ARGLU1 enhances promoter-proximal pausing of RNA polymerase II and stimulates DNA damage repair

Authors: Scott Bachus, Nikolas Akkerman, Lauren Fulham, Drayson Graves, Rafe Helwer, Jordan Rempel, Peter Pelka

Journal: Nucleic Acids Research

PubMed ID: 38520408

Doi: 10.1093/nar/gkae208

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DNA fragility at topologically associated domain boundaries is promoted by alternative DNA secondary structure and topoisomerase II activity

Authors: Heather M Raimer Young, Pei-Chi Hou, Anna R Bartosik, Naomi D Atkin, Lixin Wang, Zhenjia Wang, Aakrosh Ratan, Chongzhi Zang, Yuh-Hwa Wang

Journal: Nucleic Acids Research

PubMed ID: 38452213

Doi: 10.1093/nar/gkae164

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MiR-326 sponges TET2 triggering imbalance of Th17/Treg differentiation to exacerbate pyroptosis of hepatocytes in concanavalin A-induced autoimmune hepatitis

Authors: Genglin Zhang, Sensen Wu, Guangtao Xia

Journal: Hepatology

PubMed ID: 38043702

Doi: 10.1016/j.aohep.2023.101183

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Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology

Authors: Brendan Miller, Su-Jeong Kim, Kevin Cao, Hemal H Mehta, Neehar Thumaty, Hiroshi Kumagai, Tomomitsu Iida, Cassandra McGill, Christian J Pike, Kamila Nurmakova, Zachary A Levine, Patrick M Sullivan, Kelvin Yen, Nilüfer Ertekin-Taner, Gil Atzmon, Nir Barzilai, Pinchas Cohen

Journal: Cell

PubMed ID: 38520065

Doi: 10.1111/acel.14153

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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Authors: Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters

Journal: Nature

PubMed ID: 38509117

Doi: 10.1038/s41467-024-46644-7

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Development of a colloidal gold immunochromatographic strip for rapid detection of avian coronavirus infectious bronchitis virus

Authors: Chang-Run Zhao, Li-Ting Lin, Jin-Wen Tang, Yu Zhang, Wen Zhang, Ji-Ming Chen, Ping Wei, Teng Huang, Tian-Chao Wei, Mei-Lan Mo

Journal: Poult Sci

PubMed ID: 38574460

Doi: 10.1016/j.psj.2024.103648.

Products & Services: Proteins, Expression, Isolation and Analysis

A common protein C inhibitor exosite partially controls the heparin induced activation and inhibition of serine proteases

Authors: Urfi Siddiqui, Abdul Burhan Khan, Tahif Ahmad, Ahmed Abdur Rehman, Mohamad Aman Jairajpuri

Journal: Int J Biol Macromol

PubMed ID: 38521329

Doi: 10.1016/j.ijbiomac.2024.131065

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OsWRKY78 regulates panicle exsertion via gibberellin signaling pathway in rice

Authors: Enyang Mei, Mingliang He, Min Xu, Jiaqi Tang, Jiali Liu, Yingxiang Liu, Zhipeng Hong, Xiufeng Li, Zhenyu Wang, Qingjie Guan, Xiaojie Tian, Qingyun Bu

Journal: J Integr Plant Biol

PubMed ID: 38470298

Doi: 10.1111/jipb.13636

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins

Authors: Simonne Griffith-Jones, Lucía Álvarez, Urbi Mukhopadhyay, Sarah Gharbi, Mandy Rettel, Michael Adams, Janosch Hennig, Sagar Bhogaraju

Journal: EMBO J

PubMed ID: 38448672

Doi: 10.1038/s44318-024-00058-9

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Saikosaponin d protects pancreatic acinar cells against cerulein-induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS-STING pathway

Authors: Hui Chen, Xirong Lu, Beiqi Xu, Gang Cheng, Yuyi Li, Dan Xie

Journal: J Appl Toxicol

PubMed ID: 38462915

Doi: 10.1002/jat.4594

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Enhancing precision medicine: Bispecific antibody-mediated targeted delivery of lipid nanoparticles for potential cancer therapy

Authors: Yue Zhang, Xiaoyan Gu, Lili Huang, Yani Yang, Jun He

Journal: Int J Pharm

PubMed ID: 38467208

Doi: 10.1016/j.ijpharm.2024.123990

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Construction by artificial intelligence and immunovalidation of hypoallergenic mite allergen Der f 36 vaccine

Authors: Qiao-Zhi Qin, Jian Tang, Cai-Yun Wang, Zhi-Qiang Xu, Man Tian

Journal: Front Immunol

PubMed ID: 38601166

Doi: 10.3389/fimmu.2024.1325998

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An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy

Authors: Shibing Wang, Yuxin Li, Chuning Xu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 38458640

Doi: 10.1136/jitc-2023-008431

Products & Services: Recombinant Proteins

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

Authors: Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J Brophy, Hannah Arkin, Judith Feucht, Michael V Gormally, Christopher S Hackett, Korbinian N Kropp, Inaki Etxeberria, Smita S Chandran, Jae H Park, Katharine C Hsu, Michel Sadelain, Doron Betel, Christopher A Klebanoff

Journal: biorxiv

PubMed ID: 38464085

Doi: 10.1101/2024.02.26.582108

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Biochemical and structural analysis of N-myristoyltransferase mediated protein tagging

Authors: Paul Monassa , Frédéric Rivière , Cyril Dian , Frédéric Frottin , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230587

Doi: 10.1016/bs.mie.2023.02.016

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Kinetic and catalytic features of N-myristoyltransferases

Authors: Frédéric Rivière , Paul Monassa , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230588

Doi: 10.1016/bs.mie.2023.02.018

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A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav22 channels and utility in neuropathic pain

Authors: Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris

Journal: Biomed Pharmacother

PubMed ID: 38531121

Doi: 10.1016/j.biopha.2024.116472

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Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients

Authors: Tianming Wang, Min Gong, Yingfei Lu, Chengcheng Zhao, Ling Ling, Jianquan Chen, Rong Ju

Journal: Cell Death Discov

PubMed ID: 38472192

Doi: 10.1038/s41420-024-01899-3

Products & Services: Proteins, Expression, Isolation and Analysis

Influence of Mutations and N-Glycosylation Sites in the Receptor-Binding Domain (RBD) and the Membrane Protein of SARS-CoV-2 Variants of Concern on Antibody Binding in ELISA

Authors: Mandy Schwarze, Daniela Volke, Juan Camilo Rojas Echeverri, Robin Schick, Nicole Lakowa, Thomas Grünewald, Johannes Wolf, Stephan Borte, Markus Scholz, Andor Krizsan, Ralf Hoffmann

Journal: Biology (Basel)

PubMed ID: 38666819

Doi: 10.3390/biology13040207

Products & Services: Proteins, Expression, Isolation and Analysis

Study on the Thermal Stability of the Sweet-Tasting Protein Brazzein Based on Its Structure-Sweetness Relationship

Authors: Jingnan Zuo, Wei Zheng, Nian Shi, Rong Song, Fei Han, Chen Yang, Jingwen Li, Chao Peng, Bin Li, Yijie Chen

Journal: J Agric Food Chem

PubMed ID: 38526016

Doi: 10.1021/acs.jafc.3c09616

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Involvement of TGFBI-TAGLN axis in cancer stem cell property of head and neck squamous cell carcinoma

Authors: Motoharu Sarubo, Yasuhiro Mouri, Akira Moromizato, Azusa Yamada, Shengjan Jin, Wenhua Shao, Hiroko Hagita, Keiko Miyoshi, Yasusei Kudo

Journal: Sci Rep

PubMed ID: 38514830

Doi: 10.1038/s41598-024-57478-0

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AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation

Authors: Eva Källberg, Meliha Mehmeti-Ajradini, Frida Björk Gunnarsdottir, Marcus Göransson, Caroline Bergenfelz, Roni Allaoui Fredriksson, Catharina Hagerling, Martin E Johansson, Charlotte Welinder, Karin Jirström, Karin Leandersson

Journal: J Leukoc Biol

PubMed ID: 38060995

Doi: 10.1093/jleuko/qiad152

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Identification of mA RNA methylation genes in and expression profiling in response to different developmental and environmental stimuli

Authors: Mahbub Hasan, Zakia Sultana Nishat, Md Soyib Hasan, Tanvir Hossain, Ajit Ghosh

Journal: Biochem Biophys Rep

PubMed ID: 38511186

Doi: 10.1016/j.bbrep.2024.101677

Products & Services: Proteins, Expression, Isolation and Analysis

Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP

Authors: Avnika A Ruparelia, Margo Montandon, Jo Merriner, Cheng Huang, Siew Fen Lisa Wong, Carmen Sonntag, Justin P Hardee, Gordon S Lynch, Lee B Miles, Ashley Siegel, Thomas E Hall, Ralf B Schittenhelm, Peter D Currie

Journal: JCI Insight

PubMed ID: 38530354

Doi: 10.1172/jci.insight.167578

Products & Services: Molecular Biology Reagents

Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases

Authors: Friederike Oltmanns, Ana Vieira Antão, Pascal Irrgang, Vera Viherlehto, Leticia Jörg, Anna Schmidt, Jannik T Wagner, Michael Rückert, Ann-Sophie Flohr, Carol Imanuel Geppert, Benjamin Frey, Wibke Bayer, Claudia Gravekamp, Matthias Tenbusch, Udo Gaipl, Dennis Lapuente

Journal: J Immunother Cancer

PubMed ID: 38458636

Doi: 10.1136/jitc-2023-008652

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Oxygen Activation in Aromatic Ring Cleaving Salicylate Dioxygenase: Detection of Reaction Intermediates with a Nitro-substituted Substrate Analog

Authors: Qian Wang, Hanbin Li, Uran Bujupi, Janosch Gröning, Andreas Stolz, Angelo Bongiorno, Rupal Gupta

Journal: Chembiochem

PubMed ID: 38363551

Doi: 10.1002/cbic.202400023

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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

Authors: Julie Rageul , Natalie Lo , Amy L Phi , Jinal A Patel , Jennifer J Park , Hyungjin Kim

Journal: Cell Rep

PubMed ID: 38393943

Doi: 10.1016/j.celrep.2024.113845

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Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography

Authors: Kaylen R Meeks, Juan Ji , Mykola V Protopopov , Olga O Tarkhanova , Yurii S Moroz , John J Tanner

Journal: J Chem Inf Model

PubMed ID: 38411104

Doi: 10.1021/acs.jcim.3c01879

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Quantification of SARS-CoV-2 monoclonal IgG mass fraction by isotope dilution mass spectrometry

Authors: G Martos, M Bedu, R D Josephs, S Westwood, R I Wielgosz

Journal: Anal Bioanal Chem

PubMed ID: 38427100

Doi: 10.1007/s00216-024-05205-z

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Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution

Authors: Elena Campos-Pardos, Santiago Uranga, Ana Picó, Ana Belén Gómez, Jesús Gonzalo-Asensio

Journal: Nat Commun

PubMed ID: 38461302

Doi: 10.1038/s41467-024-46449-8

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Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

Authors: Elena Dvoretskova, May C Ho, Volker Kittke, Florian Neuhaus, Ilaria Vitali, Daniel D Lam, Irene Delgado, Chao Feng, Miguel Torres, Juliane Winkelmann, Christian Mayer

Journal: Nat Neurosci

PubMed ID: 38528203

Doi: 10.1038/s41593-024-01611-9

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The Evolution and Application of a Novel DNA Aptamer Targeting Bone Morphogenetic Protein 2 for Bone Regeneration

Authors: Mengping Liu, Andrew B Kinghorn, Lin Wang, Soubhagya K Bhuyan, Simon Chi-Chin Shiu, Julian A Tanner

Journal: Molecules

PubMed ID: 38542880

Doi: 10.3390/molecules29061243

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A pattern recognition receptor interleukin-1 receptor is involved in reproductive immunity in Macrobrachium nipponense ovary

Authors: Haifu Wan, Lei Yu, Xiaodong Cui, Shuai Guo, Shumei Mu, Xianjiang Kang

Journal: Fish Shellfish Immunol

PubMed ID: 38479568

Doi: 10.1016/j.fsi.2024.109481

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Caspase-2 protects against ferroptotic cell death

Authors: Swati Dawar, Mariana C Benitez, Yoon Lim, Toby A Dite, Jumana M Yousef, Niko Thio, Sylvain Garciaz, Thomas D Jackson, Julia V Milne, Laura F Dagley, Wayne A Phillips, Sharad Kumar, Nicholas J Clemons

Journal: Cell Death Dis

PubMed ID: 38429264

Doi: 10.1038/s41419-024-06560-6

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Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response

Authors: Hailong Qi, Zhongjie Sun, Tianle Gao, Yanling Yao, Yu Wang, Weiwei Li, Xudong Wang, Xiaofang Wang, Defang Liu, Jian-Dong Jiang

Journal: Mol Cancer

PubMed ID: 38459592

Doi: 10.1186/s12943-024-01958-4

Products & Services: Proteins, Expression, Isolation and Analysis

Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

Authors: Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N Gopalakrishna Iyer, Eliza Li Shan Fong

Journal: Adv Sci (Weinh)

PubMed ID: 38493497

Doi: 10.1002/advs.202307129

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Mutational analysis in Corynebacterium stationis MFS transporters for improving nucleotide bioproduction

Authors: Keita Kinose, Keiko Shinoda, Tomoyuki Konishi, Hisashi Kawasaki

Journal: Appl Microbiol Biotechnol

PubMed ID: 38436751

Doi: 10.1007/s00253-024-13080-y

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Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission

Authors: Fei Wang, Yu Wang, Qing-Yang Zhang, Ke-Yu Hu, Ying-Jie Song, Lin Yang, Fan Fei, Ceng-Lin Xu, Sun-Liang Cui, Ye-Ping Ruan, Yi Wang, Zhong Chen

Journal: Acta Pharmacol Sin

PubMed ID: 38514863

Doi: 10.1038/s41401-024-01257-0

Products & Services: Proteins, Expression, Isolation and Analysis

Construction of recombinant pseudorabies virus expressing PCV2 Cap, PCV3 Cap, and IL-4: investigation of their biological characteristics and immunogenicity

Authors: Yanting Yang, Zhiwen Xu, Qian Tao, Lei Xu, Sirui Gu, Yao Huang, Zheyan Liu, Yang Zhang, Jianhua Wen, Siyuan Lai, Ling Zhu

Journal: Front Immunol

PubMed ID: 38571947

Doi: 10.3389/fimmu.2024.1339387

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Expanding the molecular language of protein liquid-liquid phase separation

Authors: Shiv Rekhi, Cristobal Garcia Garcia, Mayur Barai, Azamat Rizuan, Benjamin S Schuster, Kristi L Kiick, Jeetain Mittal

Journal: Nat Chem

PubMed ID: 38553587

Doi: 10.1038/s41557-024-01489-x

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Engineering APOBEC3A deaminase for highly accurate and efficient base editing

Authors: Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng, Liren Wang, Dali Li

Journal: Nat Chem Biol

PubMed ID: 38553609

Doi: 10.1038/s41589-024-01595-4

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Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner

Authors: Yujian Wang, Jingchang Luo, Xiaolu Guan , Yan Zhao , Li Sun

Journal: Cell Death Discov

PubMed ID: 38458999

Doi: 10.1038/s41420-024-01887-7

Products & Services: Proteins, Expression, Isolation and Analysis

The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

Authors: Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, Ying Xia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu, Zhou Songyang

Journal: Cell Research

PubMed ID: 38448650

Doi: 10.1038/s41422-024-00938-z

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Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis

Authors: Shan Gao, Fangyu Wu, Sudagar S Gurcha, Sarah M Batt, Gurdyal S Besra, Zihe Rao, Lu Zhang

Journal: Nature

PubMed ID: 38491273

Doi: 10.1038/s41564-024-01643-8

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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans

Authors: M Alejandra Tortorici, Amin Addetia, Albert J Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler

Journal: Immunity

PubMed ID: 38490197

Doi: 10.1016/j.immuni.2024.02.016

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Specific protein-RNA interactions are mostly preserved in biomolecular condensates

Authors: Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric H-T Allain

Journal: SCIENCE ADVANCES

PubMed ID: 38446881

Doi: 10.1126/sciadv.adm7435

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A uniquely efficacious type of CFTR corrector with complementary mode of action

Authors: Valentina Marchesin, Lucile Monnier, Peter Blattmann, Florent Chevillard, Christine Kuntz, Camille Forny, Judith Kamper, Rolf Studer, Alexandre Bossu, Eric A Ertel, Oliver Nayler, Christine Brotschi, Jodi T Williams, John Gatfield

Journal: SCIENCE ADVANCES

PubMed ID: 38427726

Doi: 10.1126/sciadv.adk1814

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FUS reads histone H3K36me3 to regulate alternative polyadenylation

Authors: Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang

Journal: Nucleic Acids Research

PubMed ID: 38499486

Doi: 10.1093/nar/gkae184

Products & Services: Proteins, Expression, Isolation and Analysis

An optimised protocol for the expression and purification of adenovirus core protein VII

Authors: Ajani Athukorala, Karla J Helbig, Brian P McSharry, Jade K Forwood, Subir Sarker

Journal: J Virol Methods

PubMed ID: 38432358

Doi: 10.1016/j.jviromet.2024.114907

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23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling

Authors: Zeping Fan, Yaru Cui, Lanying Chen, Peng Liu, Wenbin Duan

Journal: Cancer Immunol Immunother

PubMed ID: 38554148

Doi: 10.1007/s00262-024-03662-0

Products & Services: PCR Cloning and Subcloning

mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection

Authors: Guiting Pu, Yanping Li, Tingli Liu, Hong Li, Liqun Wang, Guoliang Chen, Shanling Cao, Hong Yin, Tharheer Oluwashola Amuda, Xiaola Guo, Xuenong Luo

Journal: Parasit Vectors

PubMed ID: 38553755

Doi: 10.1186/s13071-024-06238-0

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Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics

Authors: Arshad Abdul Vahid, Muhammed Shafeek Oliyantakath Hassan, Allwin Ebenezer Sahayaraj, Ann Teres Babu, Safwa T Kizhakkeduth, Vinesh Vijayan

Journal: ACS Chem Neurosci

PubMed ID: 38433380

Doi: 10.1021/acschemneuro.3c00852

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Knockout and Replacement Gene Surgery to Treat Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa

Authors: Xuehan Sun, Chen Liang, Yangcan Chen, Tongtong Cui, Jiabao Han, Moyu Dai, Ying Zhang, Qi Zhou, Wei Li

Journal: Hum Gene Ther

PubMed ID: 38368562

Doi: 10.1089/hum.2023.201

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Uncovering the photosystem I assembly pathway in land plants

Authors: Aihong Zhang, Lin Tian, Tong Zhu, Mengyu Li, Mengwei Sun, Ying Fang, Yi Zhang, Congming Lu

Journal: Nat Plants

PubMed ID: 38503963

Doi: 10.1038/s41477-024-01658-3

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Absence of specific autoantibodies in patients with narcolepsy type 1 as indicated by an unbiased random peptide-displayed phage screening

Authors: Thi-Tuyet Trinh Tran, Thi-Hong Nhung Nguyen, Yves Dauvilliers, Roland Liblau, Xuan-Hung Nguyen

Journal: PLoS ONE

PubMed ID: 38442093

Doi: 10.1371/journal.pone.0297625

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A new trivalent recombinant protein for type 2 diabetes mellitus with oral delivery potential: design, expression, and experimental validation

Authors: Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz

Journal: J Biomol Struct Dyn

PubMed ID: 38468545

Doi: 10.1080/07391102.2024.2329290

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Bactericera cockerelli Picorna-like Virus and Three New Viruses Found Circulating in Populations of Potato/Tomato Psyllids ()

Authors: Jennifer Dahan, Gardenia E Orellana, Kaleigh B Wald, Erik J Wenninger, W Rodney Cooper, Alexander V Karasev

Journal: Viruses

PubMed ID: 38543780

Doi: 10.3390/v16030415

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Rational Design of Key Enzymes to Efficiently Synthesize Phycocyanobilin in

Authors: Ziwei Wang, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Xinrui Zhao

Journal: Biomolecules

PubMed ID: 38540721

Doi: 10.3390/biom14030301

Products & Services: Proteins, Expression, Isolation and Analysis

Continuous evolution of compact protein degradation tags regulated by selective molecular glues

Authors: Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine A Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu

Journal: Science

PubMed ID: 38484051

Doi: 10.1126/science.adk4422

Products & Services: Proteins, Expression, Isolation and Analysis

Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model

Authors: Alejandra G Martinez-Perez, Rodolfo Garza-Morales, Maria de J Loera-Arias, Sheila A Villa-Cedillo, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Orlando E Flores-Maldonado, Jesus Valdes, Jose J Perez-Trujillo, Odila Saucedo-Cardenas

Journal: Mol Biol Rep

PubMed ID: 38460043

Doi: 10.1007/s11033-024-09303-0

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Characterization of Transthyretin Mutation G47V Associated with Hereditary Cardiac Amyloidosis

Authors: Xiaopeng He, Mengdie Wang, Jialu Sun, Zhengyang Yu, Xinyang Hu, Yu Liu, Xiaoping Lin

Journal: Cardiology

PubMed ID: 38437799

Doi: 10.1159/000538081

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ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis

Authors: Qianqian Lu, Wenwen Shi, Fei Zhang, Yong Ding

Journal: Plant J

PubMed ID: 38446797

Doi: 10.1111/tpj.16707

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Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9

Authors: Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Xiaohua Guo

Journal: Cell Commun Signal

PubMed ID: 38491522

Doi: 10.1186/s12964-024-01566-1

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Reactive Oxygen Species-Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression

Authors: Liang Qi, Bo-Wen Duan, Hui Wang, Yan-Jun Liu, Han Han, Meng-Meng Han, Lei Xing, Hu-Lin Jiang, Stephen J Pandol, Ling Li

Journal: Adv Sci (Weinh)

PubMed ID: 38483920

Doi: 10.1002/advs.202401254

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Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes

Authors: Xinrui Zhou , Wan Yi Seow, Norbert Ha, Teh How Cheng, Lingfan Jiang, Jeeranan Boonruangkan, Jolene Jie Lin Goh, Shyam Prabhakar, Nigel Chou, Kok Hao Chen Affiliations expand

Journal: Nat Commun

PubMed ID: 38491027

Doi: s41467-024-46669-y

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Exploring functional genes' correlation with ()-equol concentration and new daidzein racemase identification

Authors: Yun-Fei Hu, Shu Luo, Sheng-Qi Wang, Ke-Xin Chen, Wei-Xuan Zhong, Bai-Yuan Li, Lin-Yan Cao, Hua-Hai Chen, Ye-Shi Yin

Journal: Appl Environ Microbiol

PubMed ID: 38501861

Doi: 10.1128/aem.00007-24

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Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis

Authors: Zongtao Liu, Kan Wang, Chen Jiang, Yuqi Chen, Fayuan Liu, Minghui Xie, Wai Yen Yim, Dingyi Yao, Xingyu Qian, Shiqi Chen, Jiawei Shi, Kang Xu, Yixuan Wang, Nianguo Dong

Journal: Adv Sci (Weinh)

PubMed ID: 38502885

Doi: 10.1002/advs.202307319

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Association mechanism between Arabidopsis immune coreceptor BAK1 and Pseudomonas syringae effector HopF2

Authors: Rui Han, Tongtong Zhu, Lili Zhou, Meiqing Chen, Dongli Wang, Junfeng Liu

Journal: Biochem Biophys Res Commun

PubMed ID: 38579538

Doi: 10.1016/j.bbrc.2024.149871

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Nanopore analysis of cis-diols in fruits

Authors: Pingping Fan, Zhenyuan Cao, Shanyu Zhang, Yuqin Wang, Yunqi Xiao, Wendong Jia, Panke Zhang, Shuo Huang

Journal: Nat Commun

PubMed ID: 38443434

Doi: 10.1038/s41467-024-46303-x

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MicroRNA-223-3p downregulates the inflammatory response in preeclampsia placenta via targeting NLRP3

Authors: Xueqiong Liu, Zhiyue Li, Dan Lu

Journal: BMC Pregnancy Childbirth

PubMed ID: 38448875

Doi: 10.1186/s12884-024-06371-9

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A Novel Dual-Fc Bispecific Antibody with Enhanced Fc Effector Function

Authors: Fulai Zhou, Yinyin Ben, Hao Jiang, Siwen Tan, Guangmao Mu, Zhengxia Zha, Shuting Dong, Sheng Huang, Yijun Zhou, Ying Jin, Mark L Chiu

Journal: Biochemistry

PubMed ID: 38426700

Doi: 10.1021/acs.biochem.3c00481

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A combinatorial strategy for HRV 3C protease engineering to achieve the N-terminal free cleavage

Authors: Meng Mei, Xian Fan, Yu Zhou, Faying Zhang, Guimin Zhang, Li Yi

Journal: Int J Biol Macromol

PubMed ID: 38521339

Doi: 10.1016/j.ijbiomac.2024.131066

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Characteristics of cold-adapted carbonic anhydrase and efficient carbon dioxide capture based on cell surface display technology

Authors: Yatong Wang, Quanfu Wang, Xuejing Shan, Yuwei Wu, Shumiao Hou, Ailin Zhang, Yanhua Hou

Journal: Bioresour Technol

PubMed ID: 38458264

Doi: 10.1016/j.biortech.2024.130539

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Modular vector assembly enables rapid assessment of emerging CRISPR technologies

Authors: Abby V McGee, Yanjing V Liu, Audrey L Griffith, Zsofia M Szegletes, Bronte Wen, Carolyn Kraus, Nathan W Miller, Ryan J Steger, Berta Escude Velasco, Justin A Bosch, Jonathan D Zirin, Raghuvir Viswanatha, Erik J Sontheimer, Amy Goodale, Matthew A Greene, Thomas M Green, John G Doench

Journal: Cell Genom

PubMed ID: 38484704

Doi: 10.1016/j.xgen.2024.100519

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Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals

Authors: Jimena Pérez-Vargas, Gabriel Lemieux, Connor A H Thompson, Antoine Désilets, Siobhan Ennis, Guang Gao, Danielle G Gordon, Annika Lea Schulz, Masahiro Niikura, Ivan Robert Nabi, Mel Krajden, Pierre-Luc Boudreault, Richard Leduc, François Jean

Journal: Antiviral Res

PubMed ID: 38548023

Doi: 10.1016/j.antiviral.2024.105869

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Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice

Authors: Kanwal Khalid, Hui Xuan Lim, Ayaz Anwar, Soon Hao Tan, Jung Shan Hwang, Seng-Kai Ong, Chit Laa Poh

Journal: AAPS PharmSciTech

PubMed ID: 38472523

Doi: 10.1208/s12249-024-02778-x

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HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

Authors: Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackrel

Journal: Nat Commun

PubMed ID: 38499535

Doi: 10.1038/s41467-024-46538-8

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A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges

Authors: Xingdi Cheng 1 2, Sujia Liu 3, Jing Sun 4, Lin Liu 3, Xinghuan Ma 3, Jingjiao Li 1 2, Bangda Fan 3, Chen Yang 1 2, Yuanyuan Zhao 1 2, Shuai Liu 1, Yixing Wen 1 2, Wei Li 1 2, Simin Sun 1, Shiwei Mi 1 2, Haonan Huo 1 2, Lei Miao 5, Hao Pan 6, Xiaolan Cui 4, Jiaqi Lin 3, Xueguang Lu 1 2

Journal: Adv Mater

PubMed ID: 38145557

Doi: 10.1002/adma.20231088

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LysSYL: a broad-spectrum phage endolysin targeting Staphylococcus species and eradicating S aureus biofilms

Authors: He Liu, Xuemei Wei, Zhefen Wang, Xiaonan Huang, Mengyang Li, Zhen Hu, Kexin Zhang, Qiwen Hu, Huagang Peng, Weilong Shang, Yi Yang, Yuting Wang, Shuguang Lu, Xiancai Rao

Journal: Microb Cell Fact

PubMed ID: 38528536

Doi: 10.1186/s12934-024-02359-4

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Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome

Authors: Rui Bai, Meng Yuan, Pu Zhang, Ting Luo, Yigong Shi, Ruixue Wan

Journal: Science

PubMed ID: 38484052

Doi: 10.1126/science.adn7272

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An intein-based biosensor to measure protein stability in vivo

Authors: Ahyun Son, John S Smetana, Scott Horowitz , Christopher W Lennon

Journal: Protein Sci

PubMed ID: 38380775

Doi: 10.1002/pro.4925

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MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis

Authors: Nicholas Vrettos, Jan Oppelt, Ansgar Zoch, Paraskevi Sgourdou, Haruka Yoshida, Brian Song, Ryan Fink, Dónal O'Carroll, Zissimos Mourelatos 1

Journal: Nucleic Acids Research

PubMed ID: 38520410

Doi: 10.1093/nar/gkae193

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Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells

Authors: Zhi-Liang Jing, Guang-Long Liu, Na Zhou, Dong-Yan Xu, Na Feng, Yan Lei, Li-Li Ma, Min-Shan Tang, Gui-Hui Tong, Na Tang, Yong-Jian Deng

Journal: Nature

PubMed ID: 38480774

Doi: 10.1038/s41598-024-56681-3

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Molecular basis for substrate transport of Mycobacterium tuberculosis ABC importer DppABCD

Authors: Tianyu Hu, Xiaolin Yang, Yuanchen Zhu, Fengjiang Liu, Xiuna Yang, Zhiqi Xiong, Jingxi Liang, Zhenli Lin, Yuting Ran, Luke W Guddat, Zihe Rao, Bing Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 38507491

Doi: 10.1126/sciadv.adk8521

Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

Authors: Dingfeng Li, Xinyi Gao, Xiaolin Ma, Ming Wang, Chuandong Cheng, Tian Xue, Feng Gao, Yong Shen, Juan Zhang, Qiang Liu

Journal: Cell Metab

PubMed ID: 38458203

Doi: 10.1016/j.cmet.2024.02.011.

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Unveiling a Shield of Hope: A Novel Multiepitope-Based Immunogen for Cross-Serotype Cellular Defense against Dengue Virus

Authors: Nilanshu Manocha, Daphné Laubreton, Xavier Robert, Jacqueline Marvel, Virginie Gueguen-Chaignon, Patrice Gouet, Prashant Kumar, Madhu Khanna

Journal: Vaccines (Basel)

PubMed ID: 38543950

Doi: 10.3390/vaccines12030316

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Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations

Authors: Lucas Tricoli, Sunetra Sase, Julia Hacker, Vi Pham, Sidney Smith, Maxwell Chappell, Laura Breda, Stephanie Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Peter Kurre, Rebecca Ahrens-Nicklas, Laura Adang, Adeline Vanderver, Stefano Rivella

Journal: biorxiv

PubMed ID: 38559013

Doi: 10.1101/2024.03.14.584404

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G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes

Authors: Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Daniel Jutzi, Roland Montserret, Marc-David Ruepp, Romain Parent, Christophe Combet, Fabien Zoulim, Barbara Testoni

Journal: Nucleic Acids Res

PubMed ID: 38113270

Doi: 10.1093/nar/gkad1200

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Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice

Authors: Yiling Yang, Qinggang Dai, Xin Gao, Yanfei Zhu, Mi Ri Chung, Anting Jin, Yuanqi Liu, Xijun Wang, Xiangru Huang, Siyuan Sun, Hongyuan Xu, Jingyi Liu, Lingyong Jiang

Journal: J Bone Miner Res

PubMed ID: 38477783

Doi: 10.1093/jbmr/zjae032

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Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo

Journal: Arthritis Res Ther

PubMed ID: 38509595

Doi: 10.1186/s13075-024-03308-7

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Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw

Authors: Qu Xz, Sun Zq, Liu L, Ong Hs

Journal: Appl Biochem Biotechnol

PubMed ID: 38523176

Doi: 10.1007/s12010-024-04859-w

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Structural determination and kinetic analysis of the transketolase from Vibrio vulnificus reveal unexpected cooperative behavior

Authors: Rainier-Numa Georges, Lionel Ballut, Guillaume Octobre, Arnaud Comte, Laurence Hecquet, Franck Charmantray, Bastien Doumèche

Journal: Protein Sci

PubMed ID: 38145310

Doi: 10.1002/pro.4884

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Supra-biological performance of immobilized enzymes enabled by chaperone-like specific non-covalent interactions

Authors: Héctor Sánchez-Morán, Joel L Kaar, Daniel K Schwartz

Journal: Nat Commun

PubMed ID: 38485940

Doi: 10.1038/s41467-024-46719-5

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Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition

Authors: Yi-Ting Huang, Ya-Ting Hsu, Pei-Ying Wu, Yu-Min Yeh, Peng-Chan Lin, Keng-Fu Hsu, Meng-Ru Shen

Journal: J Exp Clin Cancer Res

PubMed ID: 38424547

Doi: 10.1186/s13046-024-02987-z

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