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Barley yellow dwarf virus-GAV 17K protein disrupts thiamine biosynthesis to facilitate viral infection in plants

Authors: Xiaoyu Han, Xue Yang, Siyu Chen, He Wang, Xiaomin Liu, Daowen Wang, Jin Yang, Linlin Chen, Bingjian Sun, Honglian Li, Yan Shi

Journal: Plant J

PubMed ID: 38635415

Doi: 10.1111/tpj.16772

Products & Services: Proteins, Expression, Isolation and Analysis

Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Authors: Kristen A Baltgalvis, Kelsey N Lamb, Kent T Symons, Chu-Chiao Wu, Melissa A Hoffman, Aaron N Snead, Xiaodan Song, Thomas Glaza, Shota Kikuchi, Jason C Green, Donald C Rogness, Betty Lam, Maria E Rodriguez-Aguirre, David R Woody, Christie L Eissler, Socorro Rodiles, Seth M Negron, Steffen M Bernard, Eileen Tran, Jonathan Pollock, Ali Tabatabaei, Victor Contreras, Heather N Williams, Martha K Pastuszka, John J Sigler, Piergiorgio Pettazzoni, Markus G Rudolph, Moritz Classen, Doris Brugger, Christopher Claiborne, Jean-Marc Plancher, Isabel Cuartas, Joan Seoane, Laurence E Burgess, Robert T Abraham, David S Weinstein, Gabriel M Simon, Matthew P Patricelli, Todd M Kinsella

Journal: Nature

PubMed ID: 38658751

Doi: 10.1038/s41586-024-07318-y

Products & Services: Recombinant Proteins

MSC-derived small extracellular vesicles mitigate diabetic retinopathy by stabilizing Nrf2 through miR-143-3p-mediated inhibition of neddylation

Authors: Yueqin Chen, Jun Tong, Cong Liu, Chang He, Jinjin Xiang, Genhong Yao, Huayong Zhang, Zhenggao Xie

Journal: Free Radic Biol Med

PubMed ID: 38604315

Doi: 10.1016/j.freeradbiomed.2024.04.216

Products & Services: Molecular Biology Reagents

High mobility group box 1 mediates inflammatory responses in malignant peritoneal mesothelioma

Authors: Lianfen Wang, Xuesong Wang, Ningning Sun, Weili Liu

Journal: Int Immunopharmacol

PubMed ID: 38613884

Doi: 10.1016/j.intimp.2024.112039

Products & Services: Molecular Biology Reagents

Saccharomyces cerevisiae cellular engineering for the production of FAME biodiesel

Authors: Laiyou Wang, Bingbing Liu, Qingshan Meng, Chunchun Yang, Yiyi Hu, Chunyan Wang, Pengyu Wu, Chen Ruan, Wenhuan Li, Shuang Cheng, Shuxian Guo

Journal: AMB Express

PubMed ID: 38658521

Doi: 10.1186/s13568-024-01702-7

Products & Services: Gene Synthesis

Structural basis of human Na15 gating mechanisms

Authors: Krishna Chinthalapudi, Rupam Biswas, Ana López-Serrano, Hsiang-Ling Huang, Angelina Ramirez-Navarro, Giovanna Grandinetti, Sarah Heissler, Isabelle Deschênes

Journal: Res Sq

PubMed ID: 38659812

Doi: 10.21203/rs.3.rs-3985999/v1

Products & Services: Molecular Biology Reagents

Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy

Authors: Madison A Ward, Janakiram R Vangala, Hatem Elif Kamber Kaya, Holly A Byers, Nayyerehalsadat Hosseini, Antonio Diaz, Ana Maria Cuervo, Susmita Kaushik, Senthil K Radhakrishnan

Journal: J Cell Biol

PubMed ID: 38656405

Doi: 10.1083/jcb.202306150

Products & Services: Molecular Biology Reagents

Broadly neutralizing antibodies against emerging delta-coronaviruses

Authors: Megi Rexhepaj, Young-Jun Park, Lisa Perruzza, Daniel Asarnow, Mathew Mccallum, Katja Culap, Christian Saliba, Giada Leoni, Alessio Balmelli, Courtney N Yoshiyama, Miles S Dickinson, Joel Quispe, Jack Taylor Brown, M Alejandra Tortorici, Kaitlin R Sprouse, Ashley L Taylor, Tyler N Starr, Davide Corti, Fabio Benigni, David Veesler

Journal: biorxiv

PubMed ID: 38617231

Doi: 10.1101/2024.03.27.586411

Products & Services: Proteins, Expression, Isolation and Analysis

Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis

Authors: Xinran Wang, Ningxin Chen, Pablo Cruz-Morales, Biming Zhong, Yangming Zhang, Jian Wang, Yifan Xiao, Xinnan Fu, Yang Lin, Suneil Acharya, Zhibo Li, Huaxiang Deng, Yuhui Sun, Linquan Bai, Xiaoyu Tang, Jay D Keasling, Xiaozhou Luo

Journal: Nat Metab

PubMed ID: 38609677

Doi: 10.1038/s42255-024-01024-9

Products & Services: Gene Synthesis

Pharmacology of PACAP and VIP receptors in the spinal cord highlights the importance of the PAC receptor

Authors: Zoe Tasma, Tayla A Rees, Song Guo, Sheryl Tan, Simon J O'Carroll, Richard L M Faull, Maurice A Curtis, Sarah L Christensen, Debbie L Hay, Christopher S Walker

Journal: Br J Pharmacol

PubMed ID: 38616050

Doi: 10.1111/bph.16376

Products & Services: Proteins, Expression, Isolation and Analysis

Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling

Authors: Luca Unione, Augustinus N A Ammerlaan, Gerlof P Bosman, Elif Uslu, Ruonan Liang, Frederik Broszeit, Roosmarijn van der Woude, Yanyan Liu, Shengzhou Ma, Lin Liu, Marcos Gómez-Redondo, Iris A Bermejo, Pablo Valverde, Tammo Diercks, Ana Ardá, Robert P de Vries, Geert-Jan Boons

Journal: Nat Commun

PubMed ID: 38582892

Doi: 10.1038/s41467-024-47344-y

Products & Services: Proteins, Expression, Isolation and Analysis

Generation and characterization of a nanobody against the avian influenza virus H7 subtype

Authors: Xiuqin Huang, Weiye Li, Xuewei Cao, Qi Zhang, Yizhen Lin, Siqi Xu, Xinying Dong, Peiqi Liu, Yutong Liu, Ge He, Kaijian Luo, Saixiang Feng

Journal: Int J Biol Macromol

PubMed ID: 38593899

Doi: 10.1016/j.ijbiomac.2024.131458

Products & Services: Catalog Antibody

Dietary Hemin Remodels Gut Microbiota and Mediates Tissue Inflammation and Injury in the Small Intestine

Authors: Qian Li, Weixin Ke, Shuai Jiang, Miao Zhang, Kai Shan, Chunbao Li

Journal: Mol Nutr Food Res

PubMed ID: 38676468

Doi: 10.1002/mnfr.202300889

Products & Services: Molecular Biology Reagents

Exploring the substrate spectrum of phylogenetically distinct bacterial polyesterases

Authors: Konstantinos Makryniotis, Efstratios Nikolaivits, George Taxeidis, Jasmina Nikodinovic-Runic, Evangelos Topakas

Journal: Biotechnol J

PubMed ID: 38593303

Doi: 10.1002/biot.202400053

Products & Services: Molecular Biology Reagents

Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/Sirt1/HMGB1 signaling pathway in type 1 diabetic rats

Authors: Wenhui Yao, Rongpin Tao, Kai Wang, Xuansheng Ding

Journal: Chin J Nat Med

PubMed ID: 38658093

Doi: 10.1016/S1875-5364(24)60618-7

Products & Services: Molecular Biology Reagents

Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers

Authors: Sarah Schmidt, Meron Mengistu, Stephane Daffis, Sarah Ahmadi-Erber, Daniela Deutschmann, Tetiana Grigoriev, Ruth Chu, Cleo Leung, Adrian Tomkinson, Mohammad Nizam Uddin, Safiehkhatoon Moshkani, Michael D Robek, Jason Perry, Henning Lauterbach, Klaus Orlinger, Simon P Fletcher, Scott Balsitis

Journal: J Infect Dis

PubMed ID: 37602681

Doi: 10.1093/infdis/jiad340

Products & Services: Catalog Peptides

Structure-Based Optimization of One Neutralizing Antibody against SARS-CoV-2 Variants Bearing the L452R Mutation

Authors: Yamin Chen, Jialu Zha, Shiqi Xu, Jiang Shao, Xiaoshan Liu, Dianfan Li, Xiaoming Zhang

Journal: Viruses

PubMed ID: 38675908

Doi: 10.3390/v16040566

Products & Services: Molecular Biology Reagents

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR

Authors: Gregory Zilberg, Alexandra K Parpounas, Audrey L Warren, Bianca Fiorillo, Davide Provasi, Marta Filizola, Daniel Wacker

Journal: SCIENCE ADVANCES

PubMed ID: 37986777

Doi: 10.1101/2023.10.05.561100

Products & Services: Proteins, Expression, Isolation and Analysis

CoCas9 is a compact nuclease from the human microbiome for efficient and precise genome editing

Authors: Eleonora Pedrazzoli, Michele Demozzi, Elisabetta Visentin, Matteo Ciciani, Ilaria Bonuzzi, Laura Pezzè, Lorenzo Lucchetta, Giulia Maule, Simone Amistadi, Federica Esposito, Mariangela Lupo, Annarita Miccio, Alberto Auricchio, Antonio Casini, Nicola Segata, Anna Cereseto

Journal: Nat Commun

PubMed ID: 38658578

Doi: 10.1038/s41467-024-47800-9

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity

Authors: Vikas Tiwari, Paras Gupta, Navya Malladi, Sanjay Salgar, Sanjay K Banerjee

Journal: Free Radic Biol Med

PubMed ID: 38582228

Doi: 10.1016/j.freeradbiomed.2024.04.212

Products & Services: ORF cDNA Clones/MolecularCloud

LINC02605 involved in paediatric Mycoplasma pneumoniae pneumonia complicated with diarrhoea via miR-539-5p/CXCL1 axis

Authors: Yang Zhang, Zeming Wu

Journal: Eur J Clin Invest

PubMed ID: 38662581

Doi: 10.1111/eci.14234

Products & Services: PCR Cloning and Subcloning

Co-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis

Authors: Yue Wang, Yatu Peng, Guanghui Zi, Jin Chen, Baowei Peng

Journal: Sci Rep

PubMed ID: 38582932

Doi: 10.1038/s41598-024-58765-6

Products & Services: Proteins, Expression, Isolation and Analysis

Functionalizing Yeast Lipid Droplets as Versatile Biomaterials

Authors: Ankita Suri, Kevin K Y Hu, Tayyaba Younas, Geoff Dumsday, Victoria S Haritos

Journal: Small

PubMed ID: 38566530

Doi: 10.1002/smll.202308463

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibition of USP7 enhances CD8 T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation

Authors: Lin-Lin Sun, Li-Na Zhao, Jiao Sun, Hong-Feng Yuan, Yu-Fei Wang, Chun-Yu Hou, Pan Lv, Hui-Hui Zhang, Guang Yang, Ning-Ning Zhang, Xiao-Dong Zhang, Wei Lu

Journal: Acta Pharmacol Sin

PubMed ID: 38589688

Doi: 10.1038/s41401-024-01263-2

Products & Services: Custom Vector Construction

Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis

Authors: Yu Jeong Choi, Yoonjung Kim, Hye Jung Park, Dokyun Kim, Hyukmin Lee, Young Ah Kim, Kyung-A Lee

Journal: Ann Clin Microbiol Antimicrob

PubMed ID: 38581051

Doi: 10.1186/s12941-024-00687-2

Products & Services: Molecular Biology Reagents

Unveiling orphan receptor-like kinases in plants: novel client discovery using high-confidence library predictions in the Kinase-Client (KiC) assay

Authors: Gabriel Lemes Jorge, Daewon Kim, Chunhui Xu, Sung-Hwan Cho, Lingtao Su, Dong Xu, Laura E Bartley, Gary Stacey, Jay J Thelen

Journal: Front Plant Sci

PubMed ID: 38633461

Doi: 10.3389/fpls.2024.1372361

Products & Services: Catalog Peptides

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity

Authors: André Nguyen Dietzsch, Hadi Al-Hasani, Joachim Altschmied, Katharina Bottermann, Jana Brendler, Judith Haendeler, Susanne Horn, Isabell Kaczmarek, Antje Körner, Kerstin Krause, Kathrin Landgraf, Diana Le Duc, Laura Lehmann, Stefan Lehr, Stephanie Pick, Albert Ricken, Rene Schnorr, Angela Schulz, Martina Strnadová, Akhil Velluva, Heba Zabri, Torsten Schöneberg, Doreen Thor, Simone Prömel

Journal: Signal Transduct Target Ther

PubMed ID: 38664368

Doi: 10.1038/s41392-024-01810-7

Products & Services: Molecular Biology Reagents

Development and characterization of a bacterial enzyme cascade reaction system for efficient and stable PET degradation

Authors: Chengyong Wang, Rui Long, Xiran Lin, Wei Liu, Liying Zhu, Ling Jiang

Journal: J Hazard Mater

PubMed ID: 38703683

Doi: 10.1016/j.jhazmat.2024.134480

Products & Services: Molecular Biology Reagents

Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial

Authors: Mark Yarchoan, Edward J Gane, Thomas U Marron, Renzo Perales-Linares, Jian Yan, Neil Cooch, Daniel H Shu, Elana J Fertig, Luciane T Kagohara, Gabor Bartha, Josette Northcott, John Lyle, Sarah Rochestie, Joann Peters, Jason T Connor, Elizabeth M Jaffee, Ildiko Csiki, David B Weiner, Alfredo Perales-Puchalt, Niranjan Y Sardesai

Journal: Nat Med

PubMed ID: 38584166

Doi: 10.1038/s41591-024-02894-y

Products & Services: Molecular Biology Reagents

Chimeric Porcine Parvovirus VP2 Virus-like Particles with Epitopes of South African Serotype 2 Foot-and-Mouth Disease Virus Elicits Specific Humoral and Cellular Responses in Mice

Authors: Qian Li, Xusheng Ma, Yaner Shen, Junfei Dai, Xiaofeng Nian, Xiaofen Shang, Jiao Chen, Ashenafi Kiros Wubshet, Jie Zhang, Haixue Zheng

Journal: Viruses

PubMed ID: 38675963

Doi: 10.3390/v16040621

Products & Services: Gene Synthesis

Correction: Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo

Journal: Arthritis Res Ther

PubMed ID: 38600545

Doi: 10.1186/s13075-024-03319-4

Products & Services: Proteins, Expression, Isolation and Analysis

Functional screening of the Arabidopsis 2C protein phosphatases family identifies PP2C15 as a negative regulator of plant immunity by targeting BRI1-associated receptor kinase 1

Authors: Zhihong Diao, Rongqian Yang, Yizhu Wang, Junmei Cui, Junhao Li, Qiqi Wu, Yaxin Zhang, Xiaosong Yu, Benqiang Gong, Yan Huang, Guozhi Yu, Huipeng Yao, Jinya Guo, Huaiyu Zhang, Jinbo Shen, Andrea A Gust, Yi Cai

Journal: Mol Plant Pathol

PubMed ID: 38561315

Doi: 10.1111/mpp.13447

Products & Services: Proteins, Expression, Isolation and Analysis

Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid

Authors: Huaying Zhao, Abdullah M Syed, Mir M Khalid, Ai Nguyen, Alison Ciling, Di Wu, Wai-Ming Yau, Sanjana Srinivasan, Dominic Esposito, Jennifer A Doudna, Grzegorz Piszczek, Melanie Ott, Peter Schuck

Journal: Nucleic Acids Res

PubMed ID: 38587193

Doi: 10.1093/nar/gkae256

Products & Services: Plasmid DNA Preparation

Photo-Responsive Decellularized Small Intestine Submucosa Hydrogels

Authors: Van Thuy Duong, Han Dang Nguyen, Ngoc Ha Luong, Chun-Yi Chang, Chien-Chi Lin

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202401952

Products & Services: Peptide Synthesis

Assessing Weak Anion Binding to Small Peptides

Authors: Corinne L D Gibb, Thien H Tran, Bruce C Gibb

Journal: Journal of the American Chemical Society

PubMed ID: 38592238

Doi: 10.1021/acs.jpcb.4c00657

Products & Services: Peptide Synthesis

Detecting m6A at single-molecular resolution via direct RNA sequencing and realistic training data

Authors: Adrian Chan, Isabel S Naarmann-de Vries, Carolin P M Scheitl, Claudia Höbartner,Christoph Dieterich

Journal: Nature Communications

PubMed ID: 38637518

Doi: 10.1038/s41467-024-47661-2

Products & Services: Custom DNA/RNA Oligos

Immune microniches shape intestinal T function

Authors: Yisu Gu, Raquel Bartolomé-Casado, Chuan Xu, Alice Bertocchi, Alina Janney, Cornelia Heuberger, Claire F Pearson, Sarah A Teichmann, Emily E Thornton, Fiona Powrie

Journal: Nature

PubMed ID: 38570678

Doi: 10.1038/s41586-024-07251-0

Products & Services: Catalog Peptides

Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system

Authors: Poppy Datta, Kun Do Rhee, Rylee J Staudt, Jacob M Thompson, Ying Hsu, Salma Hassan, Arlene V Drack, Seongjin Seo

Journal: Human Molecular Genetics

PubMed ID: 38645107

Doi: 10.1101/2024.04.10.588864

Products & Services: PCR and Cloning ORF cDNA Clones/MolecularCloud

A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

Authors: Pei-Zhen Han, Wei-Dong Ye, Peng-Cheng Yu, Li-Cheng Tan, Xiao Shi, Xu-Feng Chen, Cong He, Jia-Qian Hu, Wen-Jun Wei, Zhong-Wu Lu, Ning Qu, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang

Journal: JCI Insight

PubMed ID: 38478516

Doi: 10.1172/jci.insight.173712

Products & Services: Molecular Biology Reagents

The Novel MFG-E8-derived Oligopeptide, MOP3, Improves Outcomes in a Preclinical Murine Model of Neonatal Sepsis

Authors: Colleen P Nofi, Jose M Prince, Monowar Aziz, Ping Wang

Journal: J Pediatr Surg

PubMed ID: 38582704

Doi: 10.1016/j.jpedsurg.2024.03.025

Products & Services: Peptide Synthesis

Separation and purification of short-, medium-, and long-stranded RNAs by RP-HPLC using different mobile phases and C columns with various pore sizes

Authors: Makoto Ozaki, Tomomi Kuwayama, Motoshi Shimotsuma, Tsunehisa Hirose

Journal: Anal Methods

PubMed ID: 38445900

Doi: 10.1039/d4ay00114a

Products & Services: Gene Synthesis

Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort

Authors: Brett M Cassidy, Fei Jiang, Jianguo Lin, Jian-Min Chen, Grace E Curry, Guo-Xiu Ma, Steven J Wilhelm, Shun-Jiang Deng, Guoying Zhu, Zhuan Liao, Mark E Lowe, Xunjun K Xiao, Wen-Bin Zou

Journal: Pancreatology

PubMed ID: 38485544

Doi: 10.1016/j.pan.2024.03.002

Products & Services: Mutagenesis Services

WDR4 promotes HCC pathogenesis through N-methylguanosine by regulating and interacting with METTL1

Authors: Rui Dong, Chuanxu Wang, Bo Tang, Yayu Cheng, Xuehui Peng, Xiaomin Yang, Bing Ni, Jing Li

Journal: Cell Signal

PubMed ID: 38493882

Doi: 10.1016/j.cellsig.2024.111145

Products & Services: Proteins, Expression, Isolation and Analysis

Cross-reactive CD8 T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs)

Authors: Beatrice Cavalluzzo, Marie Christine Viuff, Siri Amanda Tvingsholm, Concetta Ragone, Carmen Manolio, Angela Mauriello, Franco M Buonaguro, Maria Lina Tornesello, Francesco Izzo, Alessandro Morabito, Sine Reker Hadrup, Maria Tagliamonte, Luigi Buonaguro

Journal: J Exp Clin Cancer Res

PubMed ID: 38509571

Doi: 10.1186/s13046-024-03004-z

Products & Services: Catalog Peptides

Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro

Authors: Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Takami Yokogawa, Aiko Sano, Ryuichiro Suzuki, Masashi Kitamura

Journal: J Nat Med

PubMed ID: 38512650

Doi: 10.1007/s11418-024-01788-0

Products & Services: Molecular Biology Reagents

Diagnosis of fasciolosis antibodies in Brazilian cattle through ELISA employing both native and recombinant antigens

Authors: Guilherme Drescher, Hellen Geremias Dos Santos, Mariane Marques da Guarda Pinto, Luis Gustavo Morello, Fabiano Borges Figueiredo

Journal: Microbiol Spectr

PubMed ID: 38534120

Doi: 10.1128/spectrum.00095-24

Products & Services: Molecular Biology Reagents

Structural insights into human EMC and its interaction with VDAC

Authors: Mingyue Li, Chunli Zhang, Yuntao Xu, Shaobai Li, Chenhui Huang, Jian Wu, Ming Lei

Journal: Aging (Albany NY)

PubMed ID: 38517390

Doi: 10.18632/aging.205660

Products & Services: Proteins, Expression, Isolation and Analysis

Expression, purification, and biological activity evaluation of cathepsin L in mammalian cells

Authors: Wenwen Zhou, Baoqing You, Yifan Zheng, Shuyi Si, Yan Li, Jing Zhang

Journal: Biosci Biotechnol Biochem

PubMed ID: 38271604

Doi: 10.1093/bbb/zbae005

Products & Services: Molecular Biology Reagents

A T cell-based SARS-CoV-2 spike protein vaccine provides protection without antibodies

Authors: Juan Shi, Jian Zheng, Xiujuan Zhang, Wanbo Tai, Ryan Compas, Jack Deno, Natalie Jachym, Abhishek K Verma, Gang Wang, Xiaoqing Guan, Abby E Odle, Yushun Wan, Fang Li, Stanley Perlman, Liang Qiao, Lanying Du

Journal: JCI Insight

PubMed ID: 38456504

Doi: 10.1172/jci.insight.155789

Products & Services: Molecular Biology Reagents

Development and Evaluation of an Immunoinformatics-Based Multi-Peptide Vaccine against Infection

Authors: Sean Jeffreys, Megan P Tompkins, Jadelynn Aki, Sara B Papp, James P Chambers, M Neal Guentzel, Chiung-Yu Hung, Jieh-Juen Yu, Bernard P Arulanandam

Journal: Vaccines (Basel)

PubMed ID: 38675740

Doi: 10.3390/vaccines12040358

Products & Services: Molecular Biology Reagents

Preparation and immunogenicity evaluation of C-HapS-P6 fusion protein vaccine against nontypeable Haemophilus influenzae in mice

Authors: Nan Hu, Weifeng Li, Zihong Zhao, Yueli Chang, Cai Wang, Yutuo Zhang

Journal: Int J Med Microbiol

PubMed ID: 38461565

Doi: 10.1016/j.ijmm.2024.151616

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of Probiotic Properties and Whole-Genome Analysis of N5 and N7 Isolated from Swine

Authors: Kun Wang, Yu Wang, Lifang Gu, Jinyan Yu, Qianwen Liu, Ruiqi Zhang, Guixin Liang, Huan Chen, Fang Gu, Haoyu Liu, Xin'an Jiao, Yunzeng Zhang

Journal: Microorganisms

PubMed ID: 38674616

Doi: 10.3390/microorganisms12040672

Products & Services: DNA Sequencing

Dual mechanisms contribute to enhanced voltage dependence of an electric fish potassium channel

Authors: Jelena Todorovic, Immani Swapna, Antonio Suma, Vincenzo Carnevale, Harold Zakon

Journal: Biophys J

PubMed ID: 38429925

Doi: 10.1016/j.bpj.2024.02.028

Products & Services: Catalog Peptides

Antigenicity, epitope mapping, and intracellular distribution of the NSP7α protein of porcine reproductive and respiratory syndrome virus

Authors: Tao Wang, Da-Song Xia, Xiao-Xiao Tian, Yong-Bo Yang, Tong-Qing An

Journal: Int J Biol Macromol

PubMed ID: 38493809

Doi: 10.1016/j.ijbiomac.2024.130944

Products & Services: Proteins, Expression, Isolation and Analysis

Safety and Immunogenicity of a Messenger RNA-Based Cytomegalovirus Vaccine in Healthy Adults: Results From a Phase 1, Randomized, Clinical Trial

Authors: Carlos Fierro, Daniel Brune, Marian Shaw, Howard Schwartz, Conor Knightly, Jiang Lin, Andrea Carfi, Andrew Natenshon, Shiva Kalidindi, Caroline Reuter, Jacqueline Miller, Lori Panther

Journal: J Infect Dis

PubMed ID: 38478705

Doi: 10.1093/infdis/jiae114

Products & Services: Peptide Tools

Rapid and Mechanically Robust Immobilization of Proteins on Silica Studied at the Single-Molecule Level by Force Spectroscopy and Verified at the Macroscopic Level

Authors: Xiaoxu Zhang, Yayan Xie, Duo Huang, Xiaozhong Zhang, Xiaoyu Tang, Long Chen, Shi-Zhong Luo, Jizhong Lou, Chengzhi He

Journal: ACS Appl Mater Interfaces

PubMed ID: 38520330

Doi: 10.1021/acsami.3c18699

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The protein methyltransferase TrSAM inhibits cellulase gene expression by interacting with the negative regulator ACE1 in Trichoderma reesei

Authors: Zhihua Zhu, Gen Zou, Shunxing Chai, Meili Xiao, Yinmei Wang, Pingping Wang, Zhihua Zhou

Journal: Commun Biol

PubMed ID: 38548869

Doi: 10.1038/s42003-024-06072-1

Products & Services: Proteins, Expression, Isolation and Analysis

The human microbiota is a beneficial reservoir for SARS-CoV-2 mutations

Authors: Birong Cao, Xiaoxi Wang, Wanchao Yin, Zhaobing Gao, Bingqing Xia

Journal: MBio

PubMed ID: 38530031

Doi: 10.1128/mbio.03187-23

Products & Services: Proteins, Expression, Isolation and Analysis

Phenotypic characterization of sorghum seedlings and expression patterns of SNAC1 and DREB1A genes under water‑stress: an insight towards developing resilient cultivars

Authors: David Adedayo Animasaun · Khadijat Adetoun Adedoyin · Afeez Taiwo Bakare · Kabir Adeniran Mustapha · Mary Anuoluwapo Akinbobola · Kafayat Folasade Awujoola · Jonathan Toyin Ogunjobi

Journal: springerlink

Doi: 10.1007/s10722-024-01956-x

Products & Services: Gene Synthesis

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Authors: Stian Foss , Siri A Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz , Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg

Journal: Nature Communications

PubMed ID: 38453922

Doi: 10.1038/s41467-024-46321-9

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Decoding chromatin states by proteomic profiling of nucleosome readers

Authors: Saulius Lukauskas, Andrey Tvardovskiy, Nhuong V Nguyen , Mara Stadler, Peter Faull, Tina Ravnsborg, Bihter Özdemir Aygenli, Scarlett Dornauer, Helen Flynn, Rik G H Lindeboom, Teresa K Barth, Kevin Brockers, Stefanie M Hauck, Michiel Vermeulen, Ambrosius P Snijders, Christian L Müller, Peter A DiMaggio, Ole N Jensen, Robert Schneider, Till Bartke

Journal: Nature

PubMed ID: 38448585

Doi: 10.1038/s41586-024-07141-5

Products & Services: Codon Optimization

Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

Authors: Franziska K Kaiser, Mariana Gonzalez Hernandez, Nadine Krüger, Ellinor Englund, Wenjuan Du, Anna Z Mykytyn, Mathijs P Raadsen, Mart M Lamers

Journal: Nature Communications

PubMed ID: 38485931

Doi: 10.1038/s41467-024-46443-0

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Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions

Authors: Rosa Antón, Miguel Á Treviño, David Pantoja-Uceda, Sara Félix, María Babu, Eurico J Cabrita, Markus Zweckstetter, Philip Tinnefeld, Andrés M Vera, Javier Oroz

Journal: Nature

PubMed ID: 38431667

Doi: 10.1038/s41467-024-46236-5

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An alphacoronavirus polymerase structure reveals conserved replication factor functions

Authors: Thomas K Anderson, Peter J Hoferle, Kennan J Chojnacki, Kenneth W Lee, Joshua J Coon, Robert N Kirchdoerfer

Journal: Nucleic Acids Research

PubMed ID: 38442273

Doi: 10.1093/nar/gkae153

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Determinants of CRISPR Cas12a nuclease activation by DNA and RNA targets

Authors: Eric A Nalefski, Remy M Kooistra, Ishira Parikh, Samantha Hedley, Karunya Rajaraman, Damian Madan

Journal: Nucleic Acids Research

PubMed ID: 38477377

Doi: 10.1093/nar/gkae152

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Effects of Drag-Reducing Polymers on Hemodynamics and Whole Blood-Endothelial Interactions in 3D-Printed Vascular Topologies

Authors: Louis S Paone, Matthew Szkolnicki, Brandon J DeOre, Kiet A Tran, Noah Goldman, Allison M Andrews, Servio H Ramirez, Peter A Galie

Journal: ACS Appl Mater Interfaces

PubMed ID: 38488736

Doi: 10.1021/acsami.3c17099

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Structurally Diverse Bisbenzylisoquinoline Alkaloids with Antiadipogenic Activity through Downregulation from the Embryo of Seeds

Authors: Peiliang Zhang, Jiadong Li, Jiyao Shi, Zhihong Cheng, Tao Wu

Journal: J Nat Prod

PubMed ID: 38483204

Doi: 10.1021/acs.jnatprod.3c01290

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LINC00869 Promotes Hepatocellular Carcinoma Metastasis via Protrusion Formation

Authors: Xiaowen Shao, Yamei Dang, Tingting Zhang, Nan Bai, Jianing Huang, Mengya Guo, Li Sun, Minghe Li, Xiao Sun, Xinran Zhang, Feng Han, Ning Zhang, Hao Zhuang, Yongmei Li

Journal: Mol Cancer Res

PubMed ID: 37934195

Doi: 10.1158/1541-7786.MCR-23-0414

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Structural insights into peptidoglycan glycosidase EtgA binding to the inner rod protein EscI of the type III secretion system via a designed EscI-EtgA fusion protein

Authors: J Boorman, X Zeng, J Lin, F van den Akker

Journal: Protein Sci

PubMed ID: 38380768

Doi: 10.1002/pro.4930

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Immunoprotective effect and mechanism of rEgP29 against CD4 T cell-deficient mice with infection

Authors: Ming Li, Yazhou Zhu, Zihua Li, Jiahui Song, Wei Zhao

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 38151996

Doi: 10.3724/abbs.2023282

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Computational aptamer design for spike glycoprotein (S) (SARS CoV-2) detection with an electrochemical aptasensor

Authors: Alessia Cossettini, Laura Pasquardini, Antonello Romani, Aldo Feriani, Debora Pinamonti, Marisa Manzano

Journal: Appl Microbiol Biotechnol

PubMed ID: 38470514

Doi: 10.1007/s00253-024-13066-w

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The Hsa_circ_0105558/miR-182-5p/ATF6 Cascade Affects HO-Triggered Oxidative Damage and Apoptosis of Human Lens Epithelial Cells

Authors: Wei Mao, Zhe Zhang

Journal: Biochem Genet

PubMed ID: 38530576

Doi: 10.1007/s10528-024-10753-1

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Fibrinogen deposition promotes neuroinflammation and fibrin-derived γ peptide ameliorates neurological deficits after ischemic stroke

Authors: Lu Han, Yaying Song, Weiwei Xiang, Ze Wang, Yishu Wang, Xiajun Zhou, De-Sheng Zhu, Yangtai Guan

Journal: Int Immunopharmacol

PubMed ID: 38489969

Doi: 10.1016/j.intimp.2024.111831

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A Novel Polymer Nanoparticle Polydimethyl Diallyl Ammonium Chloride as An Adjuvant Enhances the Immune Response of SARS-CoV-2 Subunit Vaccine

Authors: Lili Ren, Chengcheng Ouyang, Shuqing Zhao, Qiqi Zheng, Weilu Guo, Baochao Fan, Jinzhu Zhou, Wei Zhang, Mi Hu, Jizong Li, Bin Li

Journal: Adv Healthc Mater

PubMed ID: 38436662

Doi: 10.1002/adhm.202304575

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Hepcidin contributes to largemouth bass (Micropterus salmoides) against bacterial infections

Authors: Weixiang Zhang, Bo Li, Ruying Yu, Wenyan Xu, Xiaoling Liu, Jianguo Su, Gailing Yuan

Journal: Int J Biol Macromol

PubMed ID: 38556234

Doi: 10.1016/j.ijbiomac.2024.131144

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Integrative analysis of metabolism subtypes and identification of prognostic metabolism-related genes for glioblastoma

Authors: Jiahui Li, Yutian Wei, Jiali Liu, Shupeng Cheng, Xia Zhang, Huaide Qiu, Jianan Li, Chuan He

Journal: Biosci Rep

PubMed ID: 38419527

Doi: 10.1042/BSR20231400

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Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy

Authors: Shao-Kang Wang, Xiao-Ting Zhang, Xuan-Yao Jiang, Bi-Jiang Geng, Tao-Lin Qing, Lei Li, Yun Chen, Jin-Feng Li, Xiao-Fang Zhang, Shuo-Gui Xu, Jiang-Bo Zhu, Yu-Ping Zhu, Mei-Tang Wang, Ji-Kuai Chen

Journal: Open Med (Wars)

PubMed ID: 38463518

Doi: 10.1515/med-2024-0898

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Genetically Encoded XTEN-based Hydrogels with Tunable Viscoelasticity and Biodegradability for Injectable Cell Therapies

Authors: Jennifer I Bennett, Mary O'Kelly Boit, Nicole E Gregorio, Fan Zhang, Ryan D Kibler, Jack W Hoye, Olivia Prado, Peter B Rapp, Charles E Murry, Kelly R Stevens, Cole A DeForest

Journal: Adv Sci (Weinh)

PubMed ID: 38477407

Doi: 10.1002/advs.202301708

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Copine proteins are required for brassinosteroid signaling in maize and Arabidopsis

Authors: Teng Jing, Yuying Wu, Yanwen Yu, Jiankun Li, Xiaohuan Mu, Liping Xu, Xi Wang, Guang Qi, Jihua Tang, Daowen Wang, Shuhua Yang, Jian Hua, Mingyue Gou

Journal: Nat Commun

PubMed ID: 38459051

Doi: 10.1038/s41467-024-46289-6

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Discordant Antigenic Properties of Soluble and Virion SARS-CoV-2 Spike Proteins

Authors: Sameer Kumar, Souradip Dasgupta, Mohammad M Sajadi, Greg A Snyder, Anthony L DeVico, Krishanu Ray

Journal: Viruses

PubMed ID: 38543772

Doi: 10.3390/v16030407

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Flublok Quadrivalent Vaccine Adjuvanted with R-DOTAP Elicits a Robust and Multifunctional CD4 T Cell Response That Is of Greater Magnitude and Functional Diversity Than Conventional Adjuvant Systems

Authors: Chantelle L White, Maryah A Glover, Siva K Gandhapudi, Katherine A Richards, Andrea J Sant

Journal: Vaccines (Basel)

PubMed ID: 38543915

Doi: 10.3390/vaccines12030281

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Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform

Authors: Marcal Yll-Pico, Yoonsuh Park, Joy Martinez, Angelina Iniguez, Mindy Kha, Taehyun Kim, Leonard Medrano, Vu H Nguyen, Teodora Kaltcheva, Shannon Dempsey, Flavia Chiuppesi, Felix Wussow, Don J Diamond

Journal: npj Vaccines

PubMed ID: 38555379

Doi: 10.1038/s41541-024-00859-3

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Authors: Yun Bai, Guanghua Cui, Xiaoke Sun, Meiqi Wei, Yanying Liu, Jialu Guo, Yu Yang

Journal: DNA Cell Biol

PubMed ID: 38466955

Doi: 10.1089/dna.2023.0392

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EGFR amplification and EGFRvIII predict and participate in TAT-Cx43266-283 antitumor response in preclinical glioblastoma models

Authors: Andrea Álvarez-Vázquez, Laura San-Segundo, Pilar Cerveró-García, Raquel Flores-Hernández, Claudia Ollauri-Ibáñez, Berta Segura-Collar, C G Hubert, Gillian Morrison, Steven M Pollard, Justin D Lathia, Pilar Sánchez-Gómez, Arantxa Tabernero

Journal: Neuro Oncol

PubMed ID: 38507464

Doi: 10.1093/neuonc/noae060

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Application of Recombinant Lactic Acid Bacteria (LAB) Live Vector Oral Vaccine in the Prevention of F4+ Enterotoxigenic

Authors: Jiangxu Yu, Jiyang Fu, Hongshuo Liu, Chao Kang, Zesong Wang, Yancheng Jin, Shuxuan Wu, Tianzhi Li, Ruicheng Yang, Meilin Jin, Huanchun Chen, Xiangru Wang

Journal: Vaccines (Basel)

PubMed ID: 38543938

Doi: 10.3390/vaccines12030304

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Engineering a Lactobacillus Lysine Riboswitch to Dynamically Control Metabolic Pathways for Lysine Production in

Authors: Qingwei Jiang, Feng Geng, Juan Shen, Ping Zhu, Zhaoxin Lu, Libang Zhou, Fengxia Lu

Journal: Microorganisms

PubMed ID: 38543657

Doi: 10.3390/microorganisms12030606

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Boosting Vaccine Response in Autoimmune Rheumatic Disease Patients With Inadequate Seroconversion: An Analysis of the Immunogenicity of Vector-Based and Inactivated Vaccines

Authors: Anuroopa Vijayan, Aswathy Sukumaran, Sara Jones, Aby Paul, Sakir Ahmed, Pankti Mehta, Manju Mohanan, Santhosh Kumar, Sreekumar Easwaran, Padmanabha Shenoy

Journal: Cureus

PubMed ID: 38586774

Doi: 10.7759/cureus.55764

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Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis

Authors: Xiao-Feng Chen, Yuan-Yuan Duan, Ying-Ying Jia, Qian-Hua Dong, Wei Shi, Yan Zhang, Shan-Shan Dong, Meng Li, Zhongbo Liu, Fei Chen, Xiao-Ting Huang, Ruo-Han Hao, Dong-Li Zhu, Rui-Hua Jing, Yan Guo, Tie-Lin Yang

Journal: Cell Genom

PubMed ID: 38335956

Doi: 1016/j.xgen.2024.100501

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piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis

Authors: Huan Wei, Jie Gao, Di-Hang Lin, Ruirong Geng, Jiaoyang Liao, Tian-Yu Huang, Guanyi Shang, Jiongjie Jing, Zong-Wei Fan, Duo Pan, Zi-Qi Yin, Tianming Li, Xinyu Liu, Shuang Zhao, Chen Chen, Jinsong Li, Xin Wang, Deqiang Ding, Mo-Fang Liu

Journal: Nat Commun

PubMed ID: 38491008

Doi: 10.1038/s41467-024-46664-3

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Influence of Mutations and N-Glycosylation Sites in the Receptor-Binding Domain (RBD) and the Membrane Protein of SARS-CoV-2 Variants of Concern on Antibody Binding in ELISA

Authors: Mandy Schwarze, Daniela Volke, Juan Camilo Rojas Echeverri, Robin Schick, Nicole Lakowa, Thomas Grünewald, Johannes Wolf, Stephan Borte, Markus Scholz, Andor Krizsan, Ralf Hoffmann

Journal: Biology (Basel)

PubMed ID: 38666819

Doi: 10.3390/biology13040207

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Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins

Authors: Simonne Griffith-Jones, Lucía Álvarez, Urbi Mukhopadhyay, Sarah Gharbi, Mandy Rettel, Michael Adams, Janosch Hennig, Sagar Bhogaraju

Journal: EMBO J

PubMed ID: 38448672

Doi: 10.1038/s44318-024-00058-9

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Saikosaponin d protects pancreatic acinar cells against cerulein-induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS-STING pathway

Authors: Hui Chen, Xirong Lu, Beiqi Xu, Gang Cheng, Yuyi Li, Dan Xie

Journal: J Appl Toxicol

PubMed ID: 38462915

Doi: 10.1002/jat.4594

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Construction by artificial intelligence and immunovalidation of hypoallergenic mite allergen Der f 36 vaccine

Authors: Qiao-Zhi Qin, Jian Tang, Cai-Yun Wang, Zhi-Qiang Xu, Man Tian

Journal: Front Immunol

PubMed ID: 38601166

Doi: 10.3389/fimmu.2024.1325998

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Identification of mA RNA methylation genes in and expression profiling in response to different developmental and environmental stimuli

Authors: Mahbub Hasan, Zakia Sultana Nishat, Md Soyib Hasan, Tanvir Hossain, Ajit Ghosh

Journal: Biochem Biophys Rep

PubMed ID: 38511186

Doi: 10.1016/j.bbrep.2024.101677

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Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP

Authors: Avnika A Ruparelia, Margo Montandon, Jo Merriner, Cheng Huang, Siew Fen Lisa Wong, Carmen Sonntag, Justin P Hardee, Gordon S Lynch, Lee B Miles, Ashley Siegel, Thomas E Hall, Ralf B Schittenhelm, Peter D Currie

Journal: JCI Insight

PubMed ID: 38530354

Doi: 10.1172/jci.insight.167578

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Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases

Authors: Friederike Oltmanns, Ana Vieira Antão, Pascal Irrgang, Vera Viherlehto, Leticia Jörg, Anna Schmidt, Jannik T Wagner, Michael Rückert, Ann-Sophie Flohr, Carol Imanuel Geppert, Benjamin Frey, Wibke Bayer, Claudia Gravekamp, Matthias Tenbusch, Udo Gaipl, Dennis Lapuente

Journal: J Immunother Cancer

PubMed ID: 38458636

Doi: 10.1136/jitc-2023-008652

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A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav22 channels and utility in neuropathic pain

Authors: Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris

Journal: Biomed Pharmacother

PubMed ID: 38531121

Doi: 10.1016/j.biopha.2024.116472

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Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients

Authors: Tianming Wang, Min Gong, Yingfei Lu, Chengcheng Zhao, Ling Ling, Jianquan Chen, Rong Ju

Journal: Cell Death Discov

PubMed ID: 38472192

Doi: 10.1038/s41420-024-01899-3

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4'--MethylbavachalconeB Targeted 14-3-3ζ Blocking the Integrin β3 Early Outside-In Signal to Inhibit Platelet Aggregation and Thrombosis

Authors: Ziqi Tang, Fanqi Lin, Zhiwen Chen, Boyang Yu, Ji-Hua Liu, Xiufeng Liu

Journal: J Agric Food Chem

PubMed ID: 38509000

Doi: 10.1021/acs.jafc.3c05211

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Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress

Authors: Yaqin Chai, Xing Gu, HongJun Zhang, Xinting Xu, Lizhan Chen

Journal: Aging (Albany NY)

PubMed ID: 38517365

Doi: 10.18632/aging.205468

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