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A cAMP-biosensor-based assay for measuring plasma arginine-vasopressin levels

Authors: Kosuke Doi, Kouki Kawakami, Tatsuya Ikuta, Asuka Inoue

Journal: Sci Rep

PubMed ID: 38658606

Doi: 10.1038/s41598-024-60035-4

Products & Services: Codon Optimization

Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

Authors: Morgan L Pimm, Brian K Haarer, Alexander D Nobles, Laura M Haney, Alexandra G Marcin, Jessica L Henty-Ridilla

Journal: biorxiv

PubMed ID: 37205555

Doi: 10.1101/2023.05.04.539490

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Distinguishing individual photobodies using Oligopaints reveals thermo-sensitive and -insensitive phytochrome B condensation at distinct subnuclear locations

Authors: Juan Du, Keunhwa Kim, Meng Chen

Journal: Nat Commun

PubMed ID: 38684657

Doi: 10.1038/s41467-024-47789-1

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MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells

Authors: Signe Meng, Ester E Sørensen, Muthulakshmi Ponniah, Jeppe Thorlacius-Ussing, Roxane Crouigneau, Tanja Larsen, Magnus T Borre, Nicholas Willumsen, Mette Flinck, Stine F Pedersen

Journal: J Cell Sci

PubMed ID: 38661040

Doi: 10.1242/jcs.261608

Products & Services: Proteins, Expression, Isolation and Analysis

Utility of accessible SARS-CoV-2 specific immunoassays in vaccinated adults with a history of advanced HIV infection

Authors: Ludovica Ferrari, Alessandra Ruggiero, Chiara Stefani, Livia Benedetti, Lorenzo Piermatteo, Eleonora Andreassi, Federica Caldara, Drieda Zace, Matteo Pagliari, Francesca Ceccherini-Silberstein, Christopher Jones, Marco Iannetta, Anna Maria Geretti

Journal: Sci Rep

PubMed ID: 38594459

Doi: 10.1038/s41598-024-58597-4

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Probing actin-activated ATP turnover kinetics of human cardiac myosin II by single molecule fluorescence

Authors: Albin Berg, Lok Priya Velayuthan, Sven Tågerud, Marko Ušaj, Alf Månsson

Journal: Cytoskeleton (Hoboken)

PubMed ID: 38623952

Doi: 10.1002/cm.21858

Products & Services: Molecular Biology Reagents

Improving the Quality of Wheat Flour Bread by a Thermophilic Xylanase with Ultra Activity and Stability Reconstructed by Ancestral Sequence and Computational-Aided Analysis

Authors: Guoshuai Hu, Xizhi Hong, Meixin Zhu, Lei Lei, Zhenggang Han, Yong Meng, Jiangke Yang

Journal: Molecules

PubMed ID: 38675714

Doi: 10.3390/molecules29081895

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Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both and

Authors: Qi-Xuan Huang, Da-Meng Fan, Zao-Zao Zheng, Ting Ran, Ao Bai, Rong-Quan Xiao, Guo-Sheng Hu, Wen Liu

Journal: J Med Chem

PubMed ID: 38569135

Doi: 10.1021/acs.jmedchem.4c00141

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Development and performance evaluation of a novel elastic bacterial nanocellulose/polyurethane small caliber artificial blood vessels

Authors: Geli Li, Luhan Bao, Gaoquan Hu, Lin Chen, Xingping Zhou, Feng F Hong

Journal: Int J Biol Macromol

PubMed ID: 38641268

Doi: 10.1016/j.ijbiomac.2024.131685

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A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage

Authors: Ting Li, Ning Ding, Hanqing Guo, Rui Hua, Zehao Lin, Huohuan Tian, Yue Yu, Daiming Fan, Zuyi Yuan, Frank J Gonzalez, Yue Wu

Journal: Cell Host & Microbe

PubMed ID: 38237593

Doi: 10.1016/j.chom.2023.12.015

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Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

Authors: Yu Zhuang , Shengjie Jiang , Xiaoling Deng , An Lao , Xiaolin Hua , Yun Xie , Lingyong Jiang , Xudong Wang , Kaili Lin

Journal: SCIENCE ADVANCES

PubMed ID: 38608014

Doi: 10.1126/sciadv.adl0372

Products & Services: Proteins, Expression, Isolation and Analysis

A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development

Authors: Zhijuan Hu 1, Liang Yang 2, Maolei Zhang 2, Haite Tang 2, Yile Huang 3, Yujie Su 4, Yingzhe Ding 3, Chong Li 2, Mengfei Wang 4, Yunhao Zhou 4, Qing Zhang 5, Liman Guo 5, Yue Wu 5, Qianqian Wang 6, Ning Liu 6, Haoran Kang 2, Yi Wu 2, Deyang Yao 2, Yukun Li 4, Zifeng Ruan 4, Hao Wang 2, Feixiang Bao 2, Guopan Liu 3, Junwei Wang 2, Yaofeng Wang 3, Wuming Wang 7, Gang Lu 7, Dajiang Qin 8, Duanqing Pei 9, Wai-Yee Chan 7, Xingguo Liu

Journal: Cell Metab

PubMed ID: 38703762

Doi: 10.1016/j.cmet.2024.04.012

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A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma

Authors: Wei Zhu, Zhiming Zhang, Jinzhang Chen, Xiaolan Chen, Lei Huang, Xiaoyong Zhang, Xuan Huang, Na Ma, Weikang Xu, Xuan Yi, Xinyu Lu, Xin Fu, Siwei Li, Guoheng Mo, Yiyue Wang, Guosheng Yuan, Mengya Zang, Qi Li, Xiaotao Jiang, Yajing He, Sha Wu, Yukai He, Yongyin Li, Jinlin Hou

Journal: Signal Transduct Target Ther

PubMed ID: 38643203

Doi: 10.1038/s41392-024-01792-6

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Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone

Authors: Yi-Ning He, Xiao-Rui Han, Dong Wang, Jia-Li Hou, Xi-Miao Hou

Journal: Biochem Biophys Res Commun

PubMed ID: 38669753

Doi: 10.1016/j.bbrc.2024.149964

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Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer

Authors: Dustin Britton, Jakub Legocki, Deven Paul, Olga Katsara, Orlando Aristizabal, Neelam Pandya, Orin Mishkit, Yingxin Xiao, Matias Aristizabal, Neha Rahman, Robert Schneider, Youssef Z Wadghiri, Jin Kim Montclare

Journal: ACS Biomater Sci Eng

PubMed ID: 38622760

Doi: 10.1021/acsbiomaterials.4c00349

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Depolymerization of SUMO chains induces slender to stumpy differentiation in T brucei bloodstream parasites

Authors: Paula Ana Iribarren, Lucía Ayelén Di Marzio, María Agustina Berazategui, Andreu Saura, Lorena Coria, Juliana Cassataro, Federico Rojas, Miguel Navarro, Vanina Eder Alvarez

Journal: PLoS Pathog

PubMed ID: 38635823

Doi: 10.1371/journal.ppat.1012166

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Identification of a homoarginine biosynthetic gene from a microcystin biosynthetic pathway in Fischerella sp PCC 9339

Authors: Xiaodan Ouyang, Matti Wahlsten, Maija Pollari, Endrews Delbaje, Jouni Jokela, David P Fewer

Journal: Toxicon

PubMed ID: 38670499

Doi: 10.1016/j.toxicon.2024.107733

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RATA: A novel class A carbapenemase with broad geographic distribution and potential for global spread

Authors: Hongyan Luo, Zhishuang Yang, Ting Lei, Caixia Li, Zuoyong Zhou, Mingshu Wang, Dekang Zhu, Pei Li, Anchun Cheng

Journal: Sci Total Environ

PubMed ID: 38692330

Doi: 10.1016/j.scitotenv.2024.172873

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Kalium channelrhodopsins effectively inhibit neurons

Authors: Stanislav Ott, Sangyu Xu, Nicole Lee, Ivan Hong, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Xianyuan Zhang, Raihanah Harion, Weiying Ye, Vaishnavi Chandramouli, Suresh Jesuthasan, Yasunori Saheki, Adam Claridge-Chang

Journal: Nat Commun

PubMed ID: 38658537

Doi: 10.1038/s41467-024-47203-w

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Characterization of 35 novel NR5A1/SF-1 variants identified in individuals with atypical sexual development: The SF1next study

Authors: Rawda Naamneh Elzenaty, Idoia Martinez de Lapiscina, Chrysanthi Kouri, Kay-Sara Sauter, Grit Sommer, Luis Castaño, Christa E Flück

Journal: J Clin Endocrinol Metab

PubMed ID: 38623954

Doi: 10.1210/clinem/dgae251

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Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases

Authors: Ana Senan-Salinas, Laura Comas, Patricia Esteban, Marcela Garzón-Tituaña, Zhiming Cheng, Llipsy Santiago, Maria Pilar Domingo, Ariel Ramírez-Labrada, José Ramón Paño-Pardo, Marc Vendrell, Julián Pardo, Maykel A Arias, Eva M Galvez

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38751645

Doi: 10.1021/acsptsci.4c00065

Products & Services: Proteins, Expression, Isolation and Analysis

Identification and Quantification of a Pneumococcal Cell Wall Polysaccharide by Antibody-Enhanced Chromatography Assay

Authors: James Z Deng, Zhifeng Chen, James Small, Yue Yuan, Kara Cox, Aimin Tang, Jeanette Roman, Liming Guan, Katrina Feller, Frances Ansbro, Kalpit Vora

Journal: Vaccines (Basel)

PubMed ID: 38793720

Doi: 10.3390/vaccines12050469

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Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis

Authors: Erwan Baudron, Sara Martinez de Lizarrondo, Maxime Gauberti, Barbara Delaunay-Piednoir, Antoine P Fournier, Denis Vivien, Fabian Docagne, Isabelle Bardou

Journal: Brain Behav Immun

PubMed ID: 38604270

Doi: 10.1016/j.bbi.2024.04.006

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An improved system to generate recombinant canine distemper virus

Authors: Huai Cheng, Hewei Zhang, Huayun Zhang, Huanchang Cai, Min Liu, Mingen Yu, Meihua Xiang, Shubo Wen, Jingqiang Ren

Journal: BMC Vet Res

PubMed ID: 38678249

Doi: 10.1186/s12917-023-03830-x

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Reverse-Phase Protein Microarrays for Overexpressed Lysates Reveal a Novel Tyrosine Kinase

Authors: Batuhan Birol Keskin, Chien-Sheng Chen, Pei-Shan Tsai, Pin-Xian Du, John Harvey M Santos, Guan-Da Syu

Journal: Anal Chem

PubMed ID: 38683735

Doi: 10.1021/acs.analchem.4c00965

Products & Services: Proteins, Expression, Isolation and Analysis

Functional and structural insights into activation of TRPV2 by weak acids

Authors: Ferdinand M Haug, Ruth A Pumroy, Akshay Sridhar, Sebastian Pantke, Florian Dimek, Tabea C Fricke, Axel Hage, Christine Herzog, Frank G Echtermeyer, Jeanne de la Roche, Adrian Koh, Abhay Kotecha, Rebecca J Howard, Erik Lindahl, Vera Moiseenkova-Bell, Andreas Leffler

Journal: EMBO J

PubMed ID: 38671253

Doi: 10.1038/s44318-024-00106-4

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Tumor vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Suppresses macrophage capping protein beyond STING activation

Authors: Zhiyong Xiao, Xia Cui, Feng Liu, Ying Wang, Xiao Liu, Wenxia Zhou, Yongxiang Zhang

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38565383

Doi: 10.1016/j.bbadis.2024.167149

Products & Services: Proteins, Expression, Isolation and Analysis

Graphene oxide films as a novel tool for the modulation of myeloid-derived suppressor cell activity in the context of multiple sclerosis

Authors: Celia Camacho-Toledano, Isabel Machín-Díaz, Rafael Lebrón-Galán, Ankor González-Mayorga, Francisco J Palomares, María C Serrano, Diego Clemente

Journal: Nanoscale

PubMed ID: 38498071

Doi: 10.1039/d3nr05351b

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Structural analyses of the GI4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies

Authors: Tomomi Kimura-Someya, Kazushige Katsura, Miyuki Kato-Murayama, Toshiaki Hosaka, Tomomi Uchikubo-Kamo, Kentaro Ihara, Kazuharu Hanada, Shin Sato, Kazutaka Murayama, Michiyo Kataoka, Mikako Shirouzu, Yuichi Someya

Journal: J Virol

PubMed ID: 38593321

Doi: 10.1128/jvi.00197-24

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Transcriptome analysis reveals the mechanism of antifungal peptide epinecidin-1 against Botrytis cinerea by mitochondrial dysfunction and oxidative stress

Authors: Li Fan, Yingying Wei, Yi Chen, Meriem Ouaziz, Shu Jiang, Feng Xu, Hongfei Wang, Xingfeng Shao

Journal: Pestic Biochem Physiol

PubMed ID: 38879298

Doi: 10.1016/j.pestbp.2024.105932

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Enhancement of SARS-CoV-2 mRNA Vaccine Efficacy through the Application of TMSB10 UTR for Superior Antigen Presentation and Immune Activation

Authors: Xiaoyan Ding, Yuxin Zhou, Jiuxiang He, Jing Zhao, Jintao Li

Journal: Vaccines (Basel)

PubMed ID: 38675814

Doi: 10.3390/vaccines12040432

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Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex

Authors: Duc Minh Nguyen, Deanna H Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, Douglas A Kuntz, Maha U Q Mian, Neil C Pomroy, Alexander F A Keszei, Samir Benlekbir, Mohammad T Mazhab-Jafari, John L Rubinstein, Terence E Hébert, Gilbert G Privé

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38625940

Doi: 10.1073/pnas.2315018121

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Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform

Authors: Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart

Journal: Nat Commun

PubMed ID: 38678031

Doi: 10.1038/s41467-024-47795-3

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A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting

Authors: Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai

Journal: Nature Microbiology

PubMed ID: 38594311

Doi: 10.1038/s41564-024-01665-2

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Antisense oligonucleotide therapeutic approach for Timothy syndrome

Authors: Xiaoyu Chen, Fikri Birey,John Huguenard, Sergiu P Pașca

Journal: Nature

PubMed ID: 38658687

Doi: 10.1038/s41586-024-07310-6

Structural basis for human Cav3.2 inhibition by selective antagonists

Authors: Jian Huang, Xiao Fan, Xueqin Jin, Chen Lyu, Qinmeng Guo, Tao Liu, Jiaofeng Chen, Amaël Davakan, Philippe Lory, Nieng Yan

Journal: Cell Research

PubMed ID: 38605177

Doi: 10.1038/s41422-024-00959-8

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Comparison of antibody-based immunotherapeutics for malignant hematological disease in an experimental murine model

Authors: Karin Frebel, Jörn C Albring, Anika Wohlgemuth, Christian Schwöppe, Stephan Hailfinger, Georg Lenz, Matthias Stelljes

Journal: Blood

PubMed ID: 38197968

Doi: 10.1182/bloodadvances.2023011647

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Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model

Authors: Nada Kojak, Junko Kuno, Kristina E Fittipaldi, Ambereen Khan, David Wenger, Michael Glasser, Roberto A Donnianni, Yajun Tang, Jade Zhang, Katie Huling, Roxanne Ally, Alejandro O Mujica, Terrence Turner, Gina Magardino, Pei Yi Huang, Sze Yen Kerk, Gustavo Droguett, Marine Prissette, Jose Rojas, Teodoro Gomez, Anthony Gagliardi, Charleen Hunt, Jeremy S Rabinowitz, Guochun Gong, William Poueymirou, Eric Chiao, Brian Zambrowicz, Chia-Jen Siao, Daisuke Kajimura

Journal: Nucleic Acids Res

PubMed ID: 38597682

Doi: 10.1093/nar/gkae250

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A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria

Authors: Nicolas Grosjean, Estella F Yee, Desigan Kumaran, Kriti Chopra, Macon Abernathy, Sandeep Biswas, James Byrnes, Dale F Kreitler, Jan-Fang Cheng, Agnidipta Ghosh, Steven C Almo, Masakazu Iwai, Krishna K Niyogi, Himadri B Pakrasi, Ritimukta Sarangi, Hubertus van Dam, Lin Yang, Ian K Blaby, Crysten E Blaby-Haas

Journal: Nature Communications

PubMed ID: 38609367

Doi: 10.1038/s41467-024-47486-z

Products & Services: Proteins, Expression, Isolation and Analysis

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency

Authors: Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Zineb Imane, Brittany Resnick, Evangelia Williams, Rui Pedro Galão, Richard Caswell, James Russ-Silsby, Yoann Seeleuthner , Darawan Rinchai, Iris Fagniez, Basilin Benson, Matthew J Dufort, Cate Speake , Megan E Smithmyer, Michelle Hudson, Rebecca Dobbs; EXE-T1D consortium; Zoe Quandt, Andrew T Hattersley ,Peng Zhang, Stephanie Boisson-Dupuis , Mark S Anderson, Jean-Laurent Casanova, Timothy I Tree, Richard A Oram

Journal: Journal Of Experimental Medicine

PubMed ID: 38634869

Doi: 10.1084/jem.20231704

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Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

Authors: Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang

Journal: Nature Communications

PubMed ID: 38565883

Doi: 10.1038/s41467-024-47069-y

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Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters

Authors: Zhi-Hui Yang 1, Yan-Li Song 1, Jie Pei 1, Song-Zhuang Li 1, Rui-Lun Liu 1, Yu Xiong 1, Jie Wu 1, Yuan-Lang Liu 1, Hui-Fen Fan 1, Jia-Hui Wu 1, Ze-Jun Wang 1, Jing Guo 1, Sheng-Li Meng 1, Xiao-Qi Chen 1, Jia Lu 1, Shuo Shen 1

Journal: Viruses

PubMed ID: 38675901

Doi: 10.3390/v16040559

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A rational designed multi-epitope vaccine elicited robust protective efficacy against Klebsiella pneumoniae lung infection

Authors: Jingwen Liao, Xiaoli Zhang, Xi Zeng, Zhuo Zhao, Tianjun Sun, Zhenping Xia, Haiming Jing, Yue Yuan, Zhifu Chen, Qiang Gou, Liqun Zhao, Weijun Zhang, Quanming Zou, Jinyong Zhang

Journal: Biomed Pharmacother

PubMed ID: 38643540

Doi: 10.1016/j.biopha.2024.116611

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Kirigami-inspired artificial spidroin microneedles for wound patches

Authors: Yongji Xiong, Yue Xu, Baoyang Lin, Bingfang He, Bingbing Gao

Journal: Int J Biol Macromol

PubMed ID: 38663709

Doi: 10.1016/j.ijbiomac.2024.131838

Products & Services: Proteins, Expression, Isolation and Analysis

Identification, Expression and Evolutional Analysis of Two Genes in Amphioxus

Authors: Yajun Wang, Jingyuan Lin, Wenjin Li, Guangdong Ji, Zhenhui Liu

Journal: Animals (Basel)

PubMed ID: 38672288

Doi: 10.3390/ani14081140

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Identification and characterization of emGalaseE, a β-1,4 galactosidase from Elizabethkingia meningoseptica, and its application on living cell surface

Authors: Yongliang Tong, Xinrong Lu, Danfeng Shen, Lin Rao, Lin Zou, Shaoxian Lyu, Linlin Hou, Guiqin Sun, Li Chen

Journal: Biological Macromolecules

PubMed ID: 38657932

Doi: 10.1016/j.ijbiomac.2024.131766

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Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing

Authors: Yan He, Xibin Zhou, Chong Chang, Ge Chen, Weikuan Liu, Geng Li, Xiaoqi Fan, Mingsun Sun, Chensi Miao, Qianyue Huang, Yunqing Ma, Fajie Yuan, Xing Chang

Journal: Mol Cell

PubMed ID: 38377993

Doi: 10.1016/j.molcel.2024.01.021

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Characterization of an O-Specific Glycosyltransferase Involved in Flagellin Glycosylation

Authors: Daisuke Fujinami, Ayumi Mizui, Azusa Miyata, Sohei Ito

Journal: ACS Chem Biol

PubMed ID: 38562012

Doi: 10.1021/acschembio.4c00045

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The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition

Authors: Bethany J Bogan, Holly C Williams, Claire M Holden, Vraj Patel, Giji Joseph, Christopher Fierro, Hugo Sepulveda, W Robert Taylor, Amir Rezvan, Alejandra San Martin

Journal: Cells

PubMed ID: 38667273

Doi: 10.3390/cells13080658

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of IGF2 promotes skin wound healing by co-expression analysis

Authors: Xingyan Liu, Ying Teng, Huan Li, Ding Luo, Hongkun Li, Jinghan Shen, Simin Du, Yuyue Zhang, Dali Wang, Jie Jing

Journal: Int Wound J

PubMed ID: 38572823

Doi: 10.1111/iwj.14862

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A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2

Authors: Lalita Mohan Behera, Pulkit Kr Gupta, Manaswini Ghosh, Sucharita Shadangi, Soumendra Rana

Journal: J Phys Chem B

PubMed ID: 38657271

Doi: 10.1021/acs.jpcb.4c00241

Products & Services: Proteins, Expression, Isolation and Analysis

Hypoxic dental pulp stem cells-released succinate promotes osteoclastogenesis and root resorption

Authors: Andi Yang, Jinmeng Wang, Zhiyu Yang, Lulu Wang, Houxuan Li, Lang Lei

Journal: Int J Med Sci

PubMed ID: 38774749

Doi: 10.7150/ijms.94972

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Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters

Authors: Krishna D Reddy, Burha Rasool, Farideh Badichi Akher, Nemanja Kutlešić, Swati Pant, Olga Boudker

Journal: biorxiv

PubMed ID: 38106174

Doi: 10.1101/2023.12.03.569786

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Unlocking the distinctive enzymatic functions of the early plant biomass deconstructive genes in a brown rot fungus by cell-free protein expression

Authors: Jesus D Castaño, Irina V El Khoury, Joshua Goering, James E Evans, Jiwei Zhang

Journal: Appl Environ Microbiol

PubMed ID: 38567954

Doi: 10.1128/aem.00122-24

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Establishment and application of a gold nanoparticle-based immunochromatographic test strip for the detection of avian leukosis virus P27 antigen in egg white samples

Authors: Chunhao Wei, Hua Kuang, Xinxin Xu, Lingling Guo, Aihua Qu, Aihong Wu, Chuanlai Xu, Liqiang Liu

Journal: Analyst

PubMed ID: 38563739

Doi: 10.1039/d4an00180j

Products & Services: Proteins, Expression, Isolation and Analysis

Heterogeneous and Cooperative Rupture of Histidine-Ni Metal-Coordination Bonds on Rationally Designed Protein Templates

Authors: Eesha Khare, Constancio Gonzalez Obeso, Zaira Martín-Moldes, Ayesha Talib, David L Kaplan, Niels Holten-Andersen, Kerstin G Blank, Markus J Buehler

Journal: ACS Biomater Sci Eng

PubMed ID: 38669114

Doi: 10.1021/acsbiomaterials.3c01819

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Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo

Authors: Cheng Siang Tan, Madinah Adrus, Sultana Parvin Habeebur Rahman, Haziq Izzuddin Muhamad Azman, Riz Anasthasia Alta Abang

Journal: BMC Vet Res

PubMed ID: 38678268

Doi: 10.1186/s12917-024-03892-5

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FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection

Authors: Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Liu

Journal: Signal Transduct Target Ther

PubMed ID: 38654010

Doi: 10.1038/s41392-024-01790-8

Products & Services: Proteins, Expression, Isolation and Analysis

The impact of glycosylation on the structure, function, and interactions of CD14

Authors: Jon Imanol Quintana, Sandra Delgado, Miriam Rábano, Mikel Azkargorta, Mirane Florencio-Zabaleta, Luca Unione, Maria dM Vivanco, Félix Elortza, Jesús Jiménez-Barbero, Ana Ardá

Journal: Glycobiology

PubMed ID: 38227775

Doi: 10.1093/glycob/cwae002

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Protocol to identify flavonoid antagonists of the SARS-CoV-2 main protease

Authors: Moua Yang, Lin Lin, Robert Flaumenhaft

Journal: STAR Protoc

PubMed ID: 38583157

Doi: 10.1016/j.xpro.2024.102990

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic-Immune Combination Therapy for Colorectal Cancer

Authors: Lu-Yi Ye, Yi-Shu Li, Tong Ge, Long-Cai Liu, Jing-Xing Si, Xue Yang, Wei-Jiao Fan, Xiao-Zhen Liu, You-Ni Zhang, Jun-Wei Wang, Shi-Bing Wang, Hai Zou, Yue-Liang Zheng, Ke-Tao Jin, Zheng-Wei Mao, Yu Cai, Xiao-Zhou Mou

Journal: Adv Healthc Mater

PubMed ID: 38551143

Doi: 10.1002/adhm.202304136

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The Y locus encodes a REPRESSOR OF PHOTOSYNTHETIC GENES protein that represses carotenoid biosynthesis via interaction with APRR2 in carrot

Authors: Ying-Gang Wang, Yu-Min Zhang, Ya-Hui Wang, Kai Zhang, Jing Ma, Jia-Xin Hang, Yu-Ting Su, Shan-Shan Tan, Hui Liu, Ai-Sheng Xiong, Zhi-Sheng Xu

Journal: Plant Cell

PubMed ID: 38593056

Doi: 10.1093/plcell/koae111

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Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses

Authors: Xuechao Tang, Sufen Li, Jinzhu Zhou, Xianyu Bian, Jianxin Wang, Nan Han, Xuejiao Zhu, Ran Tao, Wei Wang, Min Sun, Peng Li, Xuehan Zhang, Bin Li

Journal: J Virol

PubMed ID: 38591886

Doi: 10.1128/jvi.00212-24

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Proteolytic cleavage of the TGFβ co-receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell membrane

Authors: Kathrine Tejlgård Jensen, Nadia Sukusu Nielsen, Ana Viana Almeida, Ida B Thøgersen, Jan J Enghild, Seandean Lykke Harwood

Journal: FEBS J

PubMed ID: 38587194

Doi: 10.1111/febs.17128

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Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson's disease brains

Authors: Florian Ermini, Victoria F Low, Jennifer J Song, Adelie Y S Tan, Richard L M Faull, Michael Dragunow, Maurice A Curtis, Stephen S Dominy

Journal: NPJ Parkinsons Dis

PubMed ID: 38664405

Doi: 10.1038/s41531-024-00705-2

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A highly efficient blocking ELISA based on p72 monoclonal antibody for the detection of African swine fever virus antibodies and identification of its linear B cell epitope

Authors: Weldu Tesfagaber, Wan Wang, Lulu Wang, Rui Zhao, Yuanmao Zhu, Fang Li, Encheng Sun, Renqiang Liu, Zhigao Bu, Geng Meng, Dongming Zhao

Journal: Int J Biol Macromol

PubMed ID: 38642684

Doi: 10.1016/j.ijbiomac.2024.131695

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Histone derived antimicrobial peptides identified from Mytilus coruscus serum by peptidomics

Authors: Haodong Wang, Zhi Liao, Zongxin Yang, Wenhui Xiao, Zilin Yang, Jianyu He, Xiaolin Zhang, Xiaojun Yan, Changsheng Tang

Journal: Fish Shellfish Immunol

PubMed ID: 38614412

Doi: 10.1016/j.fsi.2024.109546

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MEF2C contributes to axonal branching by regulating Kif2c transcription

Authors: Ronghua Wu, Ying Sun, Zhihao Zhou, Zhangji Dong, Yan Liu, Mei Liu, Huasong Gao

Journal: Eur J Neurosci

PubMed ID: 38663879

Doi: 10.1111/ejn.16344

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Water-deficit stress induces prenylated stilbenoid production and affects biomass in peanut hairy roots: Exploring the role of stilbenoid prenyltransferase downregulation

Authors: Gaurav Gajurel, Rokib Hasan, Fabricio Medina-Bolivar

Journal: Plant Physiol Biochem

PubMed ID: 38579541

Doi: 10.1016/j.plaphy.2024.108596

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RBM3 enhances the stability of MEF2C mRNA and modulates blood-brain barrier permeability in AD microenvironment

Authors: Ye Ding, Meiqing Lin, Jirui Wang, Xiuli Shang

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38670534

Doi: 10.1016/j.bbamcr.2024.119738

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Identification of a circulating three-miRNA panel for the diagnosis of primary open angle glaucoma

Authors: Bo Qin, Li-Ping Li, Qing-Dan Xu, Yuan Lei, Yu-Hong Chen

Journal: Int Ophthalmol

PubMed ID: 38619629

Doi: 10.1007/s10792-024-03100-1

Products & Services: Proteins, Expression, Isolation and Analysis

YeeD is an essential partner for YeeE-mediated thiosulfate uptake in bacteria and regulates thiosulfate ion decomposition

Authors: Mai Ikei, Ryoji Miyazaki, Keigo Monden, Yusuke Naito, Azusa Takeuchi, Yutaro S Takahashi, Yoshiki Tanaka, Keina Murata, Takaharu Mori, Muneyoshi Ichikawa, Tomoya Tsukazaki

Journal: PLoS Biol

PubMed ID: 38656967

Doi: 10.1371/journal.pbio.3002601

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Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation

Authors: Nathan Gf Leborgne, Christelle Devisme, Nedim Kozarac, Inês Berenguer Veiga, Nadine Ebert, Aurélie Godel, Llorenç Grau-Roma, Melanie Scherer, Philippe Plattet, Volker Thiel, Gert Zimmer, Adriano Taddeo, Charaf Benarafa

Journal: JCI Insight

PubMed ID: 38470488

Doi: 10.1172/jci.insight.174133

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Photodynamic therapy upregulates expression of HIF-1α and PD-L1 in related pathways and its clinical relevance in non-small-cell lung cancer

Authors: Wen Sun, Yuan Cheng, Xiaoyu Ma, Zhou Jin, Qi Zhang, Guangfa Wang

Journal: Eur J Med Res

PubMed ID: 38609977

Doi: 10.1186/s40001-024-01780-0

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Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene and in qingke

Authors: Likun An, Ziao Wang, Yongmei Cui, Youhua Yao, Yixiong Bai, Yuehai Liu, Xin Li, Xiaohua Yao, Kunlun Wu

Journal: Open Life Sci

PubMed ID: 38681731

Doi: 10.1515/biol-2022-0855

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Identification of distinct immune signatures in inclusion body myositis by peripheral blood immunophenotyping using machine learning models

Authors: Emily McLeish, Anuradha Sooda, Nataliya Slater, Kelly Beer, Ian Cooper, Frank L Mastaglia, Merrilee Needham, Jerome D Coudert

Journal: Clin Transl Immunology

PubMed ID: 38585335

Doi: 10.1002/cti2.1504

Products & Services: Proteins, Expression, Isolation and Analysis

Lipopolysaccharide modification enhances the inhibitory effect of clodronate liposomes on hepatic fibrosis by depletion of macrophages and hepatic stellate cells

Authors: Luyao Zhang, Min Tao, Hengyan Zhang, Shichao Zhang, Xiaojuan Hou, Chen Zong, Gangqi Sun, Shiyao Feng, Haixin Yan, Ying Lu, Xue Yang, Lixin Wei, Li Zhang

Journal: Chem Biol Interact

PubMed ID: 38663797

Doi: 10.1016/j.cbi.2024.111015

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Significant but partial lipoprotein lipase functional loss caused by a novel occurrence of rare LPL biallelic variants

Authors: Yuepeng Hu, Jian-Min Chen, Han Zuo, Na Pu, Guofu Zhang, Yichen Duan, Gang Li, Zhihui Tong, Weiqin Li, Baiqiang Li, Qi Yang

Journal: Lipids Health Dis

PubMed ID: 38561841

Doi: 10.1186/s12944-024-02086-0

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Diverse Class 2 CRISPR Effectors as Active Nucleases with Expanded Targeting Capabilities

Authors: Meng Wang, Lila Rieber, Jessica van Baaren, Meaghan Morgan, Stephanie Merrett, Ian McDowell, Tyson Bowen

Journal: CRISPR J

PubMed ID: 38635326

Doi: 10.1089/crispr.2023.0058

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Identification of Enhanced Vaccine Mimotopes for the p15E Murine Cancer Antigen

Authors: Shiqi Zhou, Yiting Song, Yuan Luo, Breandan Quinn, Yang Jiao, Mark D Long, Scott I Abrams, Jonathan F Lovell

Journal: Cancer Res Commun

PubMed ID: 38506662

Doi: 10.1158/2767-9764.CRC-23-0384

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Metal-Binding Protein TaGlo1 Improves Fungal Resistance to Arsenite (As) and Methylarsenite (MAs) in Paddy Soil

Authors: Lijuan Li, Jian Tian, Ke Huang, Ximei Xue, Jian Chen, Feifei Guan, Tuo Zhang, Yifei Sun, Chao He, Xibai Zeng, Shiming Su

Journal: Environ Sci Technol

PubMed ID: 38557082

Doi: 10.1021/acs.est.3c11043

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Engineering, structure, and immunogenicity of a Crimean-Congo hemorrhagic fever virus pre-fusion heterotrimeric glycoprotein complex

Authors: Elizabeth McFadden, Stephanie R Monticelli, Albert Wang, Ajit R Ramamohan, Thomas G Batchelor, Ana I Kuehne, Russell R Bakken, Alexandra L Tse, Kartik Chandran, Andrew S Herbert, Jason S McLellan

Journal: biorxiv

PubMed ID: 38659837

Doi: 10.1101/2024.04.20.590419

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Interaction of ubiquitin-like protein SILENCING DEFECTIVE 2 with LIKE HETEROCHROMATIN PROTEIN 1 is required for regulation of anthocyanin biosynthesis in Arabidopsis thaliana in response to sucrose

Authors: Zhiyi Zhang, Chengcheng Liang, Yulong Ren, Zhaojun Lv, Jirong Huang

Journal: New Phytol

PubMed ID: 38558017

Doi: 10.1111/nph.19725

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Structural basis for dimerization of a paramyxovirus polymerase complex

Authors: Jin Xie, Mohamed Ouizougun-Oubari, Li Wang, Guanglei Zhai, Daitze Wu, Zhaohu Lin, Manfu Wang, Barbara Ludeke, Xiaodong Yan, Tobias Nilsson, Lu Gao, Xinyi Huang, Rachel Fearns, Shuai Chen

Journal: Nature Communications

PubMed ID: 38605025

Doi: 10.1038/s41467-024-47470-7

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Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1

Authors: Bin Li, Wen-Wu Bai, Tao Guo, Zhen-Yu Tang, Xue-Jiao Jing, Ti-Chao Shan, Sen Yin, Ying Li, Fu Wang, Mo-Li Zhu, Jun-Xiu Lu, Yong-Ping Bai, Bo Dong, Peng Li, Shuang-Xi Wang

Journal: Nat Commun

PubMed ID: 38580662

Doi: 10.1038/s41467-024-47327-z

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Fuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae

Authors: San Hadži, Zala Živič , Matic Kovačič , Uroš Zavrtanik , Sarah Haeserts, Daniel Charlier, Janez Plavec, Alexander N Volkov, Jurij Lah, Remy Loris

Journal: Nature Communications

PubMed ID: 38600130

Doi: 10.1038/s41467-024-47296-3

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Transcription bodies regulate gene expression by sequestering CDK9

Authors: Martino Ugolini, Maciej A Kerlin, Ksenia Kuznetsova, Haruka Oda, Hiroshi Kimura, Nadine L Vastenhouw

Journal: Nature Cell Biology

PubMed ID: 38589534

Doi: 10.1038/s41556-024-01389-9

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RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

Authors: Xian Du, Wenying Qin, Chunyu Yang, Lin Dai, Mingkui San, Yingdan Xia, Siyu Zhou, Mengyang Wang, Shuang Wu, Shaorui Zhang, Huiting Zhou, Fangshu Li, Fang He, Jingfeng Tang, Jia-Yu Chen, Yu Zhou, Rui Xiao

Journal: Genome Biology

PubMed ID: 38641822

Doi: 10.1186/s13059-024-03242-6

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Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice

Authors: Jie Dong, Lingkai Kong, Shiqun Wang, Mao Xia, Yenan Zhang, Jingyi Wu, Fuming Yang, Shuguang Zuo, Jiwu Wei

Journal: Experimental & Clinical Cancer Research

PubMed ID: 38566092

Doi: 10.1186/s13046-024-03011-0

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The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis

Authors: Victor E Cruz, Christine S Weirich, Nagesh Peddada, Jan P Erzberger

Journal: Nat Commun

PubMed ID: 38632236

Doi: 10.1038/s41467-024-47616-7

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SARS-CoV-2 nsp15 preferentially degrades AU-rich dsRNA via its dsRNA nickase activity

Authors: Xionglue Wang, Bin Zhu

Journal: Nucleic Acids Res

PubMed ID: 38634805

Doi: 10.1093/nar/gkae290

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Authors: Stephane Ferretti, Jacques Hamon, Ruben de Kanter, Clemens Scheufler，Henrik Möbitz, Marta Cortés-Cros

Journal: Nature

PubMed ID: 38658754

Doi: 10.1038/s41586-024-07350-y

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Bioactive fiber-reinforced hydrogel to tailor cell microenvironment for structural and functional regeneration of myotendinous junction

Authors: Yuzhi Sun 1, Renwang Sheng 2, Zhicheng Cao 1, Chuanquan Liu 2, Jiaxiang Li 1, Po Zhang 1, Yan Du 2, Qingyun Mo 2, Qingqiang Yao 1 3, Jialin Chen 2 3 4, Wei Zhang 2 3 4

Journal: Sci Adv

PubMed ID: 38657071

Doi: 10.1126/sciadv.adm7164

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The Transpeptidase Sortase A Binds Nucleic Acids and Mediates Mammalian Cell Labeling

Authors: Yingzheng Liu, Zhike Lu, Panfeng Wu, Zhaohui Liang, Zhenxing Yu, Ke Ni, Lijia Ma

Journal: Adv Sci (Weinh)

PubMed ID: 38581131

Doi: 10.1002/advs.202305605

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Biomolecular investigations into BBI reveal an enzymatic mechanism for PUFA isomerisation in bifidobacterium CFA bioconversion strains

Authors: Yongchao Mei, Lulu Chang, Yibin Ji, Bo Yang, Jianxin Zhao, Haiqin Chen, Wei Chen

Journal: Int J Biol Macromol

PubMed ID: 38692553

Doi: 10.1016/j.ijbiomac.2024.131836

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Precision miRNA profiling: Electrochemiluminescence powered by CRISPR-Cas13a and hybridization chain reaction

Authors: Jihua Wei, Jiayi Zhang, Wei Wang, Haidong Zhou, Huade Ma, Yuanxun Gong, Qianli Tang, Kai Zhang, Xianjiu Liao

Journal: Anal Chim Acta

PubMed ID: 38719418

Doi: 10.1016/j.aca.2024.342641

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Safe plant Hsp90 adjuvants elicit an effective immune response against SARS-CoV2-derived RBD antigen

Authors: Victor A Ramos-Duarte, Alejandro Orlowski, Carolina Jaquenod de Giusti, Mariana G Corigliano, Ariel Legarralde, Luisa F Mendoza-Morales, Agustín Atela, Manuel A Sánchez, Valeria A Sander, Sergio O Angel, Marina Clemente

Journal: Vaccine

PubMed ID: 38631949

Doi: 10.1016/j.vaccine.2024.04.036

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Chitosan-LeoA-DNA Nanoparticles Promoted the Efficacy of Novel LeoA-DNA Vaccination on Mice Against Helicobacter pylori

Authors: Zahra Ahmadzadeh Chaleshtori, Ali Asghar Rastegari, Hashem Nayeri, Abbas Doosti

Journal: Curr Microbiol

PubMed ID: 38558085

Doi: 10.1007/s00284-024-03642-8

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Identification and affinity enhancement of T-cell receptor targeting a KRAS cancer neoantigen

Authors: Mengyu Zhang, Wei Xu, Lingjie Luo, Fenghui Guan, Xiangyao Wang, Pei Zhu, Jianhua Zhang, Xuyu Zhou, Feng Wang, Sheng Ye

Journal: Commun Biol

PubMed ID: 38684865

Doi: 10.1038/s42003-024-06209-2

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Exploring immune evasion of SARS-CoV-2 variants using a pseudotyped system

Authors: Haixiao Duan, Ershuai Zhang, Ge Ren, Yining Cheng, Binfeng Yang, Lirong Liu, Normand Jolicoeur, Han Hu, Yan Xu, Binlei Liu

Journal: Heliyon

PubMed ID: 38699727

Doi: 10.1016/j.heliyon.2024.e29939

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