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An insecticide target in mechanoreceptor neurons

Authors: Xiaomu Qiao , Xiaoyu Zhang , Zhendong Zhou , Lei Guo , Weiping Wu , Suhan Ma , Xinzhong Zhang , Craig Montell , Jia Huang

Journal: Sci Adv

PubMed ID: 36417522

Doi: 10.1126/sciadv.abq3132

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis Polyclonal Antibody Services

DNA topology regulates PAM-Cas9 interaction and DNA unwinding to enable near-PAMless cleavage by thermophilic Cas9

Authors: Ya-Jing Shi , Min Duan , Jun-Mei Ding , Fan-Qi Wang , Li-Li Bi , Cai-Xiang Zhang , Yi-Zhou Zhang , Jun-Yi Duan , An-Hui Huang , Xin-Lin Lei , Hao Yin , Ying Zhang

Journal: Mol Cell

PubMed ID: 36272409

Doi: 10.1016/j.molcel.2022.09.032

Products & Services: Bacterial Expression Gene Synthesis

Rearranged endogenized plant pararetroviruses as evidence of heritable RNA-based immunity

Authors: Adrian A Valli, Irene Gonzalo-Magro, Diego H Sanchez

Journal: Mol Biol Evol

PubMed ID: 36322467

Doi: 10.1093/molbev/msac240

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Activation of a novel αAR-spinophilin-cofilin axis determines the effect of α adrenergic drugs on fear memory reconsolidation

Authors: Shalini Saggu, Yunjia Chen, Christopher Cottingham, Hasibur Rehman, Hongxia Wang, Sixue Zhang, Corinne Augelli-Szafran, Sumin Lu, Nevin Lambert, Kai Jiao, Xin-Yun Lu, Qin Wang

Journal: Mol Psychiatry

PubMed ID: 36357671

Doi: 10.1038/s41380-022-01851-w

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Ornate, large, extremophilic (OLE) RNA forms a kink turn necessary for OapC protein recognition and RNA function

Authors: Seth E Lyon, Kimberly A Harris, Nicole B Odzer, Sarah G Wilkins, Ronald R Breaker

Journal: J Biol Chem

PubMed ID: 36336078

Doi: 10.1016/j.jbc.2022.102674

Products & Services: PCR Cloning and Subcloning

FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis

Authors: Allison V Mitchell, Ling Wu, C James Block, Mu Zhang, Justin Hackett, Douglas B Craig, Wei Chen, Yongzhong Zhao, Bin Zhang, Yongjun Dang, Xiaohong Zhang, Shengping Zhang, Chuangui Wang, Heather Gibson, Lori A Pile, Benjamin Kidder, Larry Matherly, Zhe Yang, Yali Dou, Guojun Wu

Journal: Nat Commun

PubMed ID: 36319643

Doi: 10.1038/s41467-022-34239-z

Products & Services: Plasmid DNA Preparation

Antibody-mediated delivery of CRISPR-Cas9 ribonucleoproteins in human cells

Authors: Stephanie Ubiparipovic, Daniel Christ, Romain Rouet

Journal: Protein Eng Des Sel

PubMed ID: 36336952

Doi: 10.1093/protein/gzac011

Products & Services: Gene Synthesis

Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition

Authors: Simon Snoeck, Bradley W Abramson, Anthony G K Garcia, Ashley N Egan, Todd P Michael, Adam Steinbrenner

Journal: Elife

PubMed ID: 36377784

Doi: 10.7554/eLife.81050

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Biochemical Identification of a Nuclear Coactivator Protein Required for AtrR-Dependent Gene Regulation in Aspergillus fumigatus

Authors: Sanjoy Paul, Shivani Ror, W Hayes McDonald, W Scott Moye-Rowley

Journal: mSphere

PubMed ID: 36374043

Doi: 10.1128/msphere.00476-22

Products & Services: Molecular Biology Reagents

KCNQ1OT1 sponges miR-34a to promote malignant progression of malignant melanoma via upregulation of the STAT3/PD-L1 axis

Authors: Xin Wang, Zhiyao Ren, Yunfeng Xu, Xiang Gao, Hainian Huang, Fei Zhu

Journal: Environ Toxicol

PubMed ID: 36399467

Doi: 10.1002/tox.23687

Products & Services: Proteins, Expression, Isolation and Analysis

A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice

Authors: Leike Li, Yankai Wen, Daniel Wrapp, Jongmin Jeong, Peng Zhao, Wei Xiong, Constance Lynn Atkins, Zhao Shan, Deng Hui, Jason S McLellan, Ningyan Zhang, Cynthia Ju, Zhiqiang An

Journal: Antib Ther

PubMed ID: 36683763

Doi: 10.1093/abt/tbac027

Products & Services: Proteins, Expression, Isolation and Analysis

Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naïve Multiple Myeloma

Authors: Carlotta Welters, María Fernanda Lammoglia Cobo, Christian Alexander Stein, Meng-Tung Hsu, Amin Ben Hamza, Livius Penter, Xiaojing Chen, Christopher Buccitelli, Oliver Popp, Philipp Mertins, Kerstin Dietze, Lars Bullinger, Andreas Moosmann, Eric Blanc, Dieter Beule, Armin Gerbitz, Julian Strobel, Holger Hackstein, Hans-Peter Rahn, Klaus Dornmair, Thomas Blankenstein, Leo Hansmann

Journal: Cancer Immunol Res

PubMed ID: 36122410

Doi: 10.1158/2326-6066.CIR-22-0434

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An odorant receptor that senses four classes of musk compounds

Authors: Keiichi Yoshikawa, Jun Deguchi, Hu Jieying, Hsiu-Yi Lu, Hiroaki Matsunami

Journal: Curr Biol

PubMed ID: 36370695

Doi: 10.1016/j.cub.2022.10.038

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Chitosan-functionalized graphene oxide as adjuvant in HEV P239 vaccine

Authors: Qianyu Bai, Zhiwen Wang, Yina An, Jijing Tian, Zhilin Li, Yifei Yang, Yanjun Dong, Mingyong Chen, Tianlong Liu

Journal: Vaccine

PubMed ID: 36371365

Doi: 10.1016/j.vaccine.2022.11.005

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Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Authors: Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao

Journal: Biomolecules

PubMed ID: 36358958

Doi: 10.3390/biom12111608

Products & Services: PCR Cloning and Subcloning

The Immunological Epigenetic Landscape of the Human Life Trajectory

Authors: Iva Juříčková, Michael Hudec, Felix Votava, Jan Vosáhlo, Saak Victor Ovsepian, Marie Černá, Valerie Bríd O'Leary

Journal: Biomedicines

PubMed ID: 36428462

Doi: 10.3390/biomedicines10112894

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Functional and molecular dissection of HCMV long non-coding RNAs

Authors: Sungwon Lee, Hyewon Kim, Ari Hong, Jaewon Song, Sungyul Lee, Myeonghwan Kim, Sung-Yeon Hwang, Dongjoon Jeong, Jeesoo Kim, Ahyeon Son, Young-Suk Lee, V Narry Kim, Jong-Seo Kim, Hyeshik Chang, Kwangseog Ahn

Journal: Sci Rep

PubMed ID: 36369338

Doi: 10.1038/s41598-022-23317-3

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ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Authors: Alexander R van Vliet, George N Chiduza, Sarah L Maslen, Valerie E Pye, Dhira Joshi, Stefano De Tito, Harold B J Jefferies, Evangelos Christodoulou, Chloë Roustan, Emma Punch, Javier H Hervás, Nicola O'Reilly, J Mark Skehel, Peter Cherepanov, Sharon A Tooze

Journal: Mol Cell

PubMed ID: 36347259

Doi: 10.1016/j.molcel.2022.10.017

Products & Services: Proteins, Expression, Isolation and Analysis

The Integration of Proteome-Wide PTM Data with Protein Structural and Sequence Features Identifies Phosphorylations that Mediate 14-3-3 Interactions

Authors: C M Egbert, L R Warr, K L Pennington, M M Thornton, A J Vaughan, S W Ashworth, M J Heaton, N English, M P Torres, J L Andersen

Journal: J Mol Biol

PubMed ID: 36402225

Doi: 10.1016/j.jmb.2022.167890

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Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3'-end sequence elements

Authors: Francesco S Ielasi, Sara Ternifi, Emeline Fontaine, Domenico Iuso, Yohann Couté, Andrés Palencia

Journal: Nucleic Acids Res

PubMed ID: 36447390

Doi: 10.1093/nar/gkac878

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Epsilon-caprolactone-modified polyethylenimine as a genetic vehicle for stem cell-based bispecific antibody and exosome synergistic therapy

Authors: Yan Tan, Jiali Cai, Zhiyong Wang

Journal: Regen Biomater

PubMed ID: 36683744

Doi: 10.1093/rb/rbac090

Products & Services: Proteins, Expression, Isolation and Analysis

Recent progress in adaptive laboratory evolution of industrial microorganisms

Authors: Guanglu Wang, Qian Li, Zhan Zhang, Xianzhong Yin, Bingyang Wang, Xuepeng Yang

Journal: J Ind Microbiol Biotechnol

PubMed ID: 36323428

Doi: 10.1093/jimb/kuac023

Products & Services: Recombinant Antibody Expression

A KLHL40 3' UTR splice-altering variant causes milder NEM8, an under-appreciated disease mechanism

Authors: Lein N H Dofash, Gavin V Monahan, Emilia Servián-Morilla, Eloy Rivas, Fathimath Faiz, Patricia Sullivan, Emily Oates, Joshua Clayton, Rhonda L Taylor, Mark R Davis, Traude Beilharz, Nigel G Laing, Macarena Cabrera-Serrano, Gianina Ravenscroft

Journal: Hum Mol Genet

PubMed ID: 36322148

Doi: 10.1093/hmg/ddac272

Products & Services: Mammalian Expression

Insulin stimulates atypical protein kinase C-mediated phosphorylation of the neuronal adaptor FE65 to potentiate neurite outgrowth by activating ARF6-Rac1 signaling

Authors: Dennis Dik-Long Chau, Wen Li, Wai Wa Ray Chan, Jacquelyne Ka-Li Sun, Yuqi Zhai, Hei-Man Chow, Kwok-Fai Lau

Journal: FASEB J

PubMed ID: 36250347

Doi: 10.1096/fj.202200757R

Products & Services: Proteins, Expression, Isolation and Analysis

Retinal regions shape human and murine Müller cell proteome profile and functionality

Authors: Lew Kaplan, Corinne Drexler, Anna M Pfaller, Santra Brenna, Kirsten A Wunderlich, Andrea Dimitracopoulos, Juliane Merl-Pham, Maria-Theresa Perez, Ursula Schlötzer-Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M Hauck, Antje Grosche

Journal: Glia

PubMed ID: 36334068

Doi: 10.1002/glia.24283

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Trifluoro-icaritin ameliorates spared nerve injury-induced neuropathic pain by inhibiting microglial activation through α7nAChR-mediated blockade of BDNF/TrkB/KCC2 signaling in the spinal cord of rats

Authors: Dandan Jia, Guangsen Liu, Yalan Sun, Zhiping Hu, Zhihua Huang, Cheng Huang

Journal: Biomed Pharmacother

PubMed ID: 36375307

Doi: 10.1016/j.biopha.2022.114001

Products & Services: Recombinant Proteins

Comprehensive profiling of the human viral exposome in households containing an at-risk child with mitochondrial disease during the 2020-2021 COVID-19 pandemic

Authors: Eliza M Gordon-Lipkin, Christopher S Marcum, Shannon Kruk, Elizabeth Thompson, Sophie E M Kelly, Heather Kalish, Lorenza Bellusci, Surender Khurana, Kaitlyn Sadtler, Peter J McGuire

Journal: Clin Transl Med

PubMed ID: 36336785

Doi: 10.1002/ctm2.1100

Products & Services: Mammalian Expression

Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway

Authors: Yuyuan Yao, Zhichu Ren, Ruihan Yang, Yilan Mei, Yuying Dai, Qian Cheng, Chong Xu, Xiaogang Xu, Sanying Wang, Kyoung Mi Kim, Ji Heon Noh, Jian Zhu, Ningwei Zhao, Yong U Liu, Genxiang Mao, Jian Sima

Journal: Cell Biosci

PubMed ID: 36333711

Doi: 10.1186/s13578-022-00918-z

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Grafting of short elastin-like peptides using an electric field

Authors: Nuttanit Pramounmat, Sogol Asaei, Jacob D Hostert, Kathleen Young, Horst A von Recum, Julie N Renner

Journal: Sci Rep

PubMed ID: 36333395

Doi: 10.1038/s41598-022-21672-9

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How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVCV) case

Authors: Mauricio Rojas, Patricia Aceituno, Maria E Salvador, Marlid Garcia-Ordoñez, Mariana Teles, Maria Del Mar Ortega-Villaizan, Luis Perez, Nerea Roher

Journal: Fish Shellfish Immunol

PubMed ID: 36371050

Doi: 10.1016/j.fsi.2022.10.067

Products & Services: Proteins, Expression, Isolation and Analysis

Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models

Authors: Thomas Caracena, Rachel Blomberg, Rukshika S Hewawasam, Zoe E Fry, David W H Riches, Chelsea M Magin

Journal: Biomater Sci

PubMed ID: 36366982

Doi: 10.1039/d2bm00827k

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speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

Authors: Rocío Castellanos-Rueda, Raphaël B Di Roberto, Florian Bieberich, Fabrice S Schlatter, Darya Palianina, Oanh T P Nguyen, Edo Kapetanovic, Heinz Läubli, Andreas Hierlemann, Nina Khanna, Sai T Reddy

Journal: Nat Commun

PubMed ID: 36323661

Doi: 10.1038/s41467-022-34141-8

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses

Authors: Ruyu Wang, Guanglei Zhai, Guanghao Zhu, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guangbo Ge, Hongzhuan Chen, Lili Chen

Journal: Bioorg Chem

PubMed ID: 36395603

Doi: 10.1016/j.bioorg.2022.106264

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Mammalian Target of Rapamycin Inhibition Decreases Angiotensin II-Induced Steroidogenesis in HAC15 Human Adrenocortical Carcinoma Cells

Authors: Yusuf Ali, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez

Journal: Endocrinology

PubMed ID: 36320101

Doi: 10.1210/endocr/bqac185

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Broad-specificity indirect competitive enzyme-linked immunosorbent assay for aristolochic acids: Computer-aided hapten design and molecular mechanism of antibody recognition

Authors: Xiaonan Wang, Qingpeng Lu, Leina Dou, Minggang Liu, Peipei Li, Wenbo Yu, Xuezhi Yu, Zhanhui Wang, Kai Wen

Journal: Sci Total Environ

PubMed ID: 36347294

Doi: 10.1016/j.scitotenv.2022.159941

Products & Services: DNA Sequencing

New Effective Method of Lactococcus Genome Editing Using Guide RNA-Directed Transposition

Authors: Pavel Yu Pechenov, Danil A Garagulya, Daniil S Stanovov, Andrey V Letarov

Journal: Int J Mol Sci

PubMed ID: 36430465

Doi: 10.3390/ijms232213978

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Linoleic acid binds to SARS-CoV-2 RdRp and represses replication of seasonal human coronavirus OC43

Authors: Anna Goc, Waldemar Sumera, Matthias Rath, Aleksandra Niedzwiecki

Journal: Sci Rep

PubMed ID: 36352079

Doi: 10.1038/s41598-022-23880-9

Products & Services: DNA Sequencing

Alginate-Chitosan Hydrogel Formulations Sustain Baculovirus Delivery and VEGFA Expression Which Promotes Angiogenesis for Wound Dressing Applications

Authors: Sabrina Schaly, Paromita Islam, Ahmed Abosalha, Jacqueline L Boyajian, Dominique Shum-Tim, Satya Prakash

Journal: Pharmaceuticals (Basel)

PubMed ID: 36355553

Doi: 10.3390/ph15111382

Products & Services: Plasmid DNA Preparation

PNGase H + variant from Rudaea cellulosilytica with improved deglycosylation efficiency for rapid analysis of eukaryotic N-glycans and hydrogen deuterium exchange mass spectrometry analysis of glycoproteins

Authors: Rui-Rui Guo, Tian-Chan Zhang, Thomas Ole Tandrup Lambert, Ting Wang, Josef Voglmeir, Kasper D Rand, Li Liu

Journal: Rapid Commun Mass Spectrom

PubMed ID: 35945033

Doi: 10.1002/rcm.9376

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The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice

Authors: Karianne Fjeld, Anny Gravdal, Ranveig S Brekke, Jahedul Alam, Steven J Wilhelm, Khadija El Jellas, Helene N Pettersen, Jianguo Lin, Marie H Solheim, Solrun J Steine, Bente B Johansson, Pål R Njølstad, Caroline S Verbeke, Xunjun Xiao, Mark E Lowe, Anders Molven

Journal: Pancreatology

PubMed ID: 36379850

Doi: 10.1016/j.pan.2022.11.003

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Immune responses of hemocytes in the blood clam Tegillarca granosa in response to in vivo Vibrio harveyi infection

Authors: Qianyuan Yang, Guoqiang Xiao, Ran Chen, Xiaolin Huang, Shuangshuang Teng

Journal: Fish Shellfish Immunol

PubMed ID: 36435369

Doi: 10.1016/j.fsi.2022.11.035

Products & Services: Proteins, Expression, Isolation and Analysis

Seroepidemiological and genomic investigation of SARS-CoV-2 spread in North East region of India

Authors: Romi Wahengbam, Pankaj Bharali, Prasenjit Manna, Tridip Phukan, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Anil Kumar Singh, Rituraj Konwar, Channakeshavaiah Chikkaputtaiah, Natarajan Velmurugan, Selvaraman Nagamani, Hridoy Jyoti Mahanta, Himakshi Sarma, Ravi Kumar Sahu, Prachurjya Dutta, Sawlang Borsingh Wann, Jatin Kalita, G Narahari Sastry

Journal: Indian J Med Microbiol

PubMed ID: 36371334

Doi: 10.1016/j.ijmmb.2022.10.011

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SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1

Authors: Di Wang, Weiwei Liang, Di Huo, Hongyong Wang, Ying Wang, Chaohua Cong, Chunting Zhang, Shi Yan, Ming Gao, Xiaoli Su, Xingli Tan, Wenmo Zhang, Ling Han, Dongmei Zhang, Honglin Feng

Journal: Cell Death Differ

PubMed ID: 36443440

Doi: 10.1038/s41418-022-01089-7

Products & Services: Proteins, Expression, Isolation and Analysis

PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1

Authors: Yuzhong Chen, Wanqing Liang, Jun Du, Jiachi Ma, Rongrui Liang, Min Tao

Journal: Exp Cell Res

PubMed ID: 36400182

Doi: 10.1016/j.yexcr.2022.113413

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TMBIM5 is the Ca /H antiporter of mammalian mitochondria

Authors: Shane Austin, Ronald Mekis, Sami E M Mohammed, Mariafrancesca Scalise, Wen-An Wang, Michele Galluccio, Christina Pfeiffer, Tamara Borovec, Katja Parapatics, Dijana Vitko, Nora Dinhopl, Nicolas Demaurex, Keiryn L Bennett, Cesare Indiveri, Karin Nowikovsky

Journal: EMBO Rep

PubMed ID: 36321428

Doi: 10.15252/embr.202254978

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Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections

Authors: Catherine B Blackwood, Margalida Mateu-Borrás, Emel Sen-Kilic, Gage M Pyles, Sarah Jo Miller, Kelly L Weaver, William T Witt, Annalisa B Huckaby, Jason Kang, Courtney E Chandler, Robert K Ernst, F Heath Damron, Mariette Barbier

Journal: npj Vaccines

PubMed ID: 36357402

Doi: 10.1038/s41541-022-00562-1

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Heat shock protein 20 suppresses breast carcinogenesis by inhibiting the MAPK and AKT signaling pathways

Authors: Yinxi Yang, Yifeng Wu, Lihong Hou, Xin Ge, Guoquan Song, Hongdou Jin

Journal: Oncol Lett

PubMed ID: 36380873

Doi: 10.3892/ol.2022.13582

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Prevalence of Neospora caninum, Toxoplasma gondii and Brucella abortus in water buffalo (Bubalus bubalis): Climatic and environmental risk factors in eastern and southeast Mexico

Authors: J Baltazar-Pérez, F Utrera-Quintana, J Camacho-Ronquillo, R González-Garduño, H Jiménez-Cortez, A Villa-Mancera