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synDNA-a Synthetic DNA Spike-in Method for Absolute Quantification of Shotgun Metagenomic Sequencing

Authors: Livia S Zaramela, Megan Tjuanta, Oriane Moyne, Maxwell Neal, Karsten Zengler

Journal: mSystems

PubMed ID: 36317886

Doi: 10.1128/msystems.00447-22

Products & Services: Gene Synthesis

Transport of symbiont-encoded cellulases from the gill to the gut of shipworms via the enigmatic ducts of Deshayes: a 174-year mystery solved

Authors: Marvin A Altamia, Daniel L Distel

Journal: Proc Biol Sci

PubMed ID: 36350208

Doi: 10.1098/rspb.2022.1478

Products & Services: Recombinant Antibody Expression

Genome-wide identification of FAR gene family and functional analysis of NlFAR10 during embryogenesis in the brown planthopper Nilaparvata lugens

Authors: Xiaobin Fan, Wenqing Zhang

Journal: Int J Biol Macromol

PubMed ID: 36375673

Doi: 10.1016/j.ijbiomac.2022.11.075

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A basal actinopterygian melanocortin receptor: molecular and functional characterization of an Mc2r ortholog from the Senegal bichir (Polypterus senegalus).

Authors: Ciaran A Shaughnessy , Mary F Jensen , Robert M Dores

Journal: Gen Comp Endocrinol

PubMed ID: 35973587

Doi: 10.1016/j.ygcen.2022.114105

Products & Services: Gene Synthesis

A genetic approach to identify amino acids in Gcn1 required for Gcn2 activation

Authors: Susanne Gottfried , Siaosi M B M J Koloamatangi , Clement Daube , Anja H Schiemann , Evelyn Sattlegger

Journal: PLoS One

PubMed ID: 36441697

Doi: doi.org/10.1371/journal.pone.0277648

Products & Services: Plasmid DNA Preparation DNA Sequencing

Lipid metabolism reprogramming in colorectal cancer

Authors: Dan Chen, Xuebing Zhou, PengYu Yan, Chunyu Yang, Yuan Li, Longzhe Han, Xiangshan Ren

Journal: J Cell Biochem

PubMed ID: 36334309

Doi: 10.1002/jcb.30347

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Correction: Identification of novel HLA-A*11:01-restricted HPV16 E6/E7 epitopes and T-cell receptors for HPV-related cancer immunotherapy

Authors:

Journal: J Immunother Cancer

PubMed ID: 36332929

Doi: 10.1136/jitc-2022-004790corr1

Products & Services: Mammalian Expression

Autoimmune haemolytic anaemia

Authors: María Argüello Marina, Montserrat López Rubio, Lucía Castilla García

Journal: Med Clin (Barc)

PubMed ID: 36334945

Doi: 10.1016/j.medcli.2022.07.021

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Analysis of the HbpA Protein from Corynebacterium diphtheriae Clinical Isolates and Identification of a Putative Hemoglobin-Binding Site on HbpA

Authors: Lindsey R Lyman, Justine Schaeffer, Werner Ruppitsch, Michael P Schmitt

Journal: J Bacteriol

PubMed ID: 36346227

Doi: 10.1128/jb.00349-22

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Allosteric potentiation of GABA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis

Authors: Elizabeth S Chan, Yang Ge, Yee Wah So, Yun-Fei Bai, Lidong Liu, Yu Tian Wang

Journal: Cell Rep

PubMed ID: 36323250

Doi: 10.1016/j.celrep.2022.111584

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A Δ42PD1 fusion-expressing DNA vaccine elicits enhanced adaptive immune response to HIV-1: the key role of TLR4

Authors: Lin Cheng, Xian Tang, Yun He, Bin Ju, Hui Wang

Journal: Virol J

PubMed ID: 36320043

Doi: 10.1186/s12985-022-01909-9

Products & Services: Peptide Synthesis

Phosphate limitation intensifies negative effects of ocean acidification on globally important nitrogen fixing cyanobacterium

Authors: Futing Zhang, Zuozhu Wen, Shanlin Wang, Weiyi Tang, Ya-Wei Luo, Sven A Kranz, Haizheng Hong, Dalin Shi

Journal: Nat Commun

PubMed ID: 36344528

Doi: 10.1038/s41467-022-34586-x

Products & Services: Molecular Biology Tools

TARDBP promotes ovarian cancer progression by altering vascular endothelial growth factor splicing

Authors: Yutian He, Zhenbo OuYang, Wenwen Liu, Yu Chen, Qiushi Zhang

Journal: Oncogene

PubMed ID: 36369320

Doi: 10.1038/s41388-022-02539-9

Products & Services: Gene Synthesis

Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties

Authors: Hannah N Corman, Jessica N Ross, Francisco R Fields, Douglas A Shoue, Shaun W Lee, Mary Ann McDowell

Journal: Microbiol Spectr

PubMed ID: 36342284

Doi: 10.1128/spectrum.02658-22

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Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections

Authors: Catherine B Blackwood, Margalida Mateu-Borrás, Emel Sen-Kilic, Gage M Pyles, Sarah Jo Miller, Kelly L Weaver, William T Witt, Annalisa B Huckaby, Jason Kang, Courtney E Chandler, Robert K Ernst, F Heath Damron, Mariette Barbier

Journal: npj Vaccines

PubMed ID: 36357402

Doi: 10.1038/s41541-022-00562-1

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Identification of African swine fever virus MGF505-2R as a potent inhibitor of innate immunity in vitro

Authors: Huaguo Huang, Wen Dang, Zhengwang Shi, Mingyang Ding, Fan Xu, Tao Li, Tao Feng, Haixue Zheng, Shuqi Xiao

Journal: Virol Sin

PubMed ID: 36442611

Doi: 10.1016/j.virs.2022.11.009

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism

Authors: Jie Shen, Qian Zha, Qian-Hua Yang, Yue-Qian Zhou, Xiao Liang, Ying-Jie Chen, Gui-Xia Qi, Xiao-Jin Zhang, Wen-Bing Yao, Xiang-Dong Gao, Song Chen

Journal: Acta Pharmacol Sin

PubMed ID: 36357669

Doi: 10.1038/s41401-022-01014-1

Products & Services: Combinatorial DNA Libraries

Quantum Dot-Based Molecular Beacons for Quantitative Detection of Nucleic Acids with CRISPR/Cas(N) Nucleases

Authors: Christopher M Green, Joseph Spangler, Kimihiro Susumu, David A Stenger, Igor L Medintz, Sebastián A Díaz

Journal: ACS Nano

PubMed ID: 36378103

Doi: 10.1021/acsnano.2c07749

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Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells

Authors: Kristina V Kitaeva , Daria S Chulpanova , Margarita N Zhuravleva , Ivan Yu Filin , Ruslan M Deviatiiarov , Alyssa C Ballard-Reisch , Albert A Rizvanov , Valeriya V Solovyeva

Journal: Bioengineering (Basel) .

PubMed ID: 36354566

Doi: 10.3390/bioengineering9110655

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Antibody and T Cell Immune Responses to SARS-CoV-2 Peptides in COVID-19 Convalescent Patients

Authors: Kristina V Kitaeva , Daria S Chulpanova , Margarita N Zhuravleva , Ivan Yu Filin , Ruslan M Deviatiiarov , Alyssa C Ballard-Reisch , Albert A Rizvanov , Valeriya V Solovyeva

Journal: Bioengineering (Basel) .

PubMed ID: 36354566

Doi: 10.3389/fmicb.2022.842232

Products & Services: Gene Synthesis

Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications

Authors: Dominik Aschenbrenner, Ziqing Ye, Ying Zhou, Wenhui Hu, Isabel Brooks, Isabelle Williams, Melania Capitani, Lisa Gartner, Daniel Kotlarz, Scott B Snapper, Christoph Klein, Aleixo M Muise, Brian D Marsden, Ying Huang, Holm H Uhlig

Journal: J Clin Immunol

PubMed ID: 36370291

Doi: 10.1007/s10875-022-01366-7

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An engineered (CAGA)-EGFP cell-based biosensor for high-content and accurate detection of active TGF-β

Authors: Qian Ruan, Xuezhen Lin, Lixia Wang, Niu Wang, Yu Zhao, Hao Wang, Fu-Ying Tian, Ning Hu, Ying Li, Bo Zhao

Journal: Biosens Bioelectron

PubMed ID: 36403492

Doi: 10.1016/j.bios.2022.114884

Products & Services: Proteins, Expression, Isolation and Analysis

A reversible cell penetrating peptide-cargo linkage allows dissection of cell penetrating peptide- and cargo-dependent effects on internalization and identifies new functionalities of putative endolytic peptides

Authors: Daniel P Morris, Lucy C Snipes, Stephanie A Hill, Michael M Woods, Maria M Mbugua, Lydia R Wade, Jonathan L McMurry

Journal: Front Pharmacol .

PubMed ID: 36479201

Doi: 10.3389/fphar.2022.1070464

Products & Services: Gene Synthesis

Chaperoning activity of the cyclophilin family prevents tau aggregation

Authors: Shannon E Hill , Abigail R Esquivel , Santiago Rodriguez Ospina , Lauren M Rahal , Chad A Dickey , Laura J Blair

Journal: Protein Sci

PubMed ID: 36305768

Doi: 10.1002/pro.4448

Products & Services: PCR Cloning and Subcloning

Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes

Authors: Zeyu Jin , Li Wan , Yuqi Zhang , Xuecheng Li , Yong Cao , Haobin Liu , Shengyao Fan , Du Cao , Zhengmao Wang , Xiaobo Li , Junmin Pan , Meng-Qiu Dong , Jianping Wu , Zhen Yan

Journal: Cell

PubMed ID: 36413996

Doi: 10.1016/j.cell.2022.10.030

Products & Services: Proteins, Expression, Isolation and Analysis

Structure/function studies on the activation motif of two non-mammalian Mrap1 orthologs, and observations on the phylogeny of Mrap1, including a novel characterization of an Mrap1 from the chondrostean fish, Polyodon spathula.

Authors: Robert M. Dores , Greer McKinley, Audrey Meyers, Morgan Martin and Ciaran A. Shaughnessy

Journal: Biomolecules

Doi: 10.3390/biom12111681

Products & Services: Gene Synthesis

Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both mitochondrial RNA splicing and editing and is crucial for endosperm development

Authors: Hang Yang , Yunlong Wang , Yunlu Tian , Xuan Teng , Zehui Lv , Jie Lei , Erchao Duan , Hui Dong , Xue Yang , Yuanyan Zhang , Yinglun Sun , Xiaoli Chen , Xiuhao Bao , Rongbo Chen , Chuanwei Gu , Yipeng Zhang , Xiaokang Jiang , Wenyu Ma , Pengcheng Zhang , Yi Ji , Yu Zhang , Yihua Wang , Jianmin Wan

Journal: J Integr Plant Biol

PubMed ID: 36333887

Doi: 10.1111/jipb.13402

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The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6

Authors: Jonathan E Barnes, Peik K Lund-Andersen, Jagdish Suresh Patel, F Marty Ytreberg

Journal: Sci Rep

PubMed ID: 36335244

Doi: 10.1038/s41598-022-23482-5

Products & Services: Proteins, Expression, Isolation and Analysis

Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes

Authors: Neil Berry, Deborah Ferguson, Sarah Kempster, Jo Hall, Claire Ham, Adrian Jenkins, Vicky Rannow, Elaine Giles, Rose Leahy, Sara Goulding, Arturo Fernandez, Yemisi Adedeji, Sandrine Vessillier, Deepa Rajagopal, Sandra Prior, Yann Le Duff, Matthew Hurley, Sarah Gilbert, Martin Fritzsche, Ryan Mate, Nicola Rose, Robert J Francis, Kirsty MacLellan-Gibson, Alejandro Suarez-Bonnet, Simon Priestnall, Neil Almond

Journal: Sci Rep

PubMed ID: 36333445

Doi: 10.1038/s41598-022-23339-x

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Design and optimization of enzymatic activity in a de novo β-barrel scaffold

Authors: Yakov Kipnis, Anissa Ouald Chaib, Anastassia A Vorobieva, Guangyang Cai, Gabriella Reggiano, Benjamin Basanta, Eshan Kumar, Peer R E Mittl, Donald Hilvert, David Baker

Journal: Protein Sci

PubMed ID: 36305767

Doi: 10.1002/pro.4405

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Association of neutrophil extracellular traps with fistula healing in patients with complex perianal fistulising Crohn's disease

Authors: Dongxing Cao, Keyu Qian, Ying Zhao, Jie Hong, Haoyan Chen, Xiaohui Wang, Nailin Yang, Cheng Zhang, Jingkai Cao, Keyu Jia, Guangyu Wu, Mingming Zhu, Jun Shen, Ye Zhang, Zhe Cui, Zheng Wang

Journal: J Crohns Colitis

PubMed ID: 36322703

Doi: 10.1093/ecco-jcc/jjac171

Products & Services: Polyclonal Antibody Services

Ectopic circSTK39 expression ameliorates hydrogen peroxide-induced human lens epithelial cell apoptosis and oxidative stress through the miR-125a-5p/ERCC6 pathway

Authors: Ming Guo, Fanfan Su, Yao Chen, Bo Su

Journal: Curr Eye Res

PubMed ID: 36322706

Doi: 10.1080/02713683.2022.2143529

Products & Services: Proteins, Expression, Isolation and Analysis

Developmentally regulated mitochondrial biogenesis and cell death competence in maize pollen

Authors: Karen C Chamusco, May N Milazzo, Kanchan S Bhan, Terry L Kamps, Prestina Smith, Modupeoluwa Durojaiye, Cristina D Moreira, Maria Gallo, Christine D Chase

Journal: BMC Plant Biol

PubMed ID: 36316635

Doi: 10.1186/s12870-022-03897-y

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A microbial transporter of the dietary antioxidant ergothioneine

Authors: Daniel G Dumitrescu, Elizabeth M Gordon, Yekaterina Kovalyova, Anna B Seminara, Brianna Duncan-Lowey, Emily R Forster, Wen Zhou, Carmen J Booth, Aimee Shen, Philip J Kranzusch, Stavroula K Hatzios

Journal: Cell

PubMed ID: 36347253

Doi: 10.1016/j.cell.2022.10.008

Products & Services: Plasmid DNA Preparation

Identification of a novel ALDH1A3-selective inhibitor by a chemical probe with unrelated bioactivity: An approach to affinity-based drug target discovery

Authors: Hiroshi Kamiyama, Masayuki Miyano, Daisuke Ito, Takayuki Kimura, Koji Hagiwara, Hiroyuki Kogai, Yosuke Kaburagi, Yoshihiko Kotake, Yasutaka Takase

Journal: Chem Biol Drug Des

PubMed ID: 36334047

Doi: 10.1111/cbdd.14176

Products & Services: Plasmid DNA Preparation

Base-editing-mediated dissection of a γ-globin cis-regulatory element for the therapeutic reactivation of fetal hemoglobin expression

Authors: Panagiotis Antoniou, Giulia Hardouin, Pierre Martinucci, Giacomo Frati, Tristan Felix, Anne Chalumeau, Letizia Fontana, Jeanne Martin, Cecile Masson, Megane Brusson, Giulia Maule, Marion Rosello, Carine Giovannangeli, Vincent Abramowski, Jean-Pierre de Villartay, Jean-Paul Concordet, Filippo Del Bene, Wassim El Nemer, Mario Amendola, Marina Cavazzana, Anna Cereseto, Oriana Romano, Annarita Miccio

Journal: Nat Commun

PubMed ID: 36333351

Doi: 10.1038/s41467-022-34493-1

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Proteomic Landscape and Deduced Functions of the Cardiac 14-3-3 Protein Interactome

Authors: Jia-Hua Qu, Kirill V Tarasov, Khalid Chakir, Yelena S Tarasova, Daniel R Riordon, Edward G Lakatta

Journal: Cells

PubMed ID: 36359893

Doi: 10.3390/cells11213496

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of commercially available fully automated and ELISA-based assays for detecting anti-SARS-CoV-2 neutralizing antibodies

Authors: Hadeel T Zedan, Hadi M Yassine, Duaa W Al-Sadeq, Na Liu, Hamda Qotba, Eleonora Nicolai, Massimo Pieri, Sergio Bernardini, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Sci Rep

PubMed ID: 36347859

Doi: 10.1038/s41598-022-21317-x

Products & Services: Proteins, Expression, Isolation and Analysis

Fitness Costs of pfhrp2 and pfhrp3 Deletions Underlying Diagnostic Evasion in Malaria Parasites

Authors: Shalini Nair, Xue Li, Standwell C Nkhoma, Tim Anderson

Journal: J Infect Dis

PubMed ID: 35709327

Doi: 10.1093/infdis/jiac240

Products & Services: Plasmid DNA Preparation

Sequestration of a dual function DNA-binding protein by Vibrio cholerae CRP

Authors: Jacob A Gibson, Michael J Gebhardt, Renato E R S Santos, Simon L Dove, Paula I Watnick

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36343262

Doi: 10.1073/pnas.2210115119

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Structure-based engineering of minimal Proline dehydrogenase domains for inhibitor discovery

Authors: Alexandra N Bogner, Juan Ji, John J Tanner

Journal: Protein Eng Des Sel

PubMed ID: 36448708

Doi: 10.1093/protein/gzac016

Products & Services: Plasmids for SARS-CoV-2 Detection and Research

Sustained Activation of CLR/RAMP Receptors by Gel-Forming Agonists

Authors: Chia Lin Chang, Zheqing Cai, Sheau Yu Teddy Hsu

Journal: Int J Mol Sci

PubMed ID: 36362188

Doi: 10.3390/ijms232113408

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Detection of concentration-dependent conformational changes in SARS-CoV-2 nucleoprotein by agarose native gel electrophoresis

Authors: Ryo Sato, Yui Tomioka, Chiaki Sakuma, Masataka Nakagawa, Yasunori Kurosawa, Kohei Shiba, Tsutomu Arakawa, Teruo Akuta

Journal: Anal Biochem

PubMed ID: 36427555

Doi: 10.1016/j.ab.2022.114995

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Selection of Brucella abortus mimetic epitopes for fast diagnostic purposes in cattle

Authors: Fabiana de Almeida Araújo Santos, Patrícia Tiemi Fujimura, Emília Rezende Vaz, Ana Cristina Honorato de Castro, Ana Graci Brito-Madurro, Vivian Alonso-Goulart, Luciana Machado Bastos, Belchiolina Beatriz Fonseca, Anna Monteiro Correia Lima, Luiz Ricardo Goulart

Journal: Vet Res Commun

PubMed ID: 36445603

Doi: 10.1007/s11259-022-10043-4

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A Vaccine of SARS-CoV-2 S Protein RBD Induces Protective Immunity

Authors: Qiaoqiao Qu, Pengfei Hao, Wang Xu, Letian Li, Yuhang Jiang, Zhiqiang Xu, Jing Chen, Zihan Gao, Zhaoxia Pang, Ningyi Jin, Chang Li

Journal: Int J Mol Sci

PubMed ID: 36430190

Doi: 10.3390/ijms232213716

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Insights into glycosidic bond specificity of an engineered selective α-L-rhamnosidase N12-Rha via activity assays and molecular modelling

Authors: Bo Yu, Shiyu Luo, Yuhan Ding, Zijie Gong, Ting Nie

Journal: AMB Express

PubMed ID: 36370155

Doi: 10.1186/s13568-022-01489-5

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Bovine milk exosomes affected proliferation of macrophages under hypoxia

Authors: Svjetlana Matic, Vermont P Dia

Journal: Curr Res Food Sci

PubMed ID: 36387601

Doi: 10.1016/j.crfs.2022.11.002

Products & Services: Proteins, Expression, Isolation and Analysis

A glutamine-based single α-helix scaffold to target globular proteins

Authors: Albert Escobedo, Jonathan Piccirillo, Juan Aranda, Tammo Diercks, Borja Mateos, Carla Garcia-Cabau, Macarena Sánchez-Navarro, Busra Topal, Mateusz Biesaga, Lasse Staby, Birthe B Kragelund, Jesús García, Oscar Millet, Modesto Orozco, Murray Coles, Ramon Crehuet, Xavier Salvatella

Journal: Nat Commun

PubMed ID: 36400768

Doi: 10.1038/s41467-022-34793-6

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Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Authors: Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng, Yongchang Yan, Mengjia Hong, Dan Zhang, Changming Luan, Shun Zhang, Hao Wu, Hongyi Gao, Sijia Bai, Changqing Li, Ruoyi Ding, Niannian Xue, Zhixin Lei, Yuting Chen, Yuting Guan, Stefan Siwko, Yiyun Cheng, Gaojie Song, Liren Wang, Chengqi Yi, Mingyao Liu, Dali Li

Journal: Nat Biotechnol

PubMed ID: 36357717

Doi: 10.1038/s41587-022-01532-7

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A switchable Cas12a enabling CRISPR-based direct histone deacetylase activity detection

Authors: Wenyuan Kang , Lin Liu , Peihang Yu , Tianyi Zhang , Chunyang Lei , Zhou Nie

Journal: Biosens Bioelectron

PubMed ID: 35700604

Doi: doi.org/10.1016/j.bios.2022.114468

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