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Development of quantitative multiplex RT-qPCR one step assay for detection of hepatitis delta virus

Authors: Jackson Alves da Silva Queiroz, Tárcio Peixoto Roca, Rutilene Barbosa Souza, Luiz Fellype Alves de Souza, Ana Maísa Passos-Silva, André Luiz Ferreira da Silva, Eugênia de Castro E Silva, Lourdes Maria Pinheiro Borzacov, Rita de Cássia Pontello Rampazzo, Soraya Dos Santos Pereira, Thor Oliveira Dantas, Janaína Mazaro, Lívia Melo Villar, Juan Miguel Villalobos Salcedo, Daniel Archimedes da Matta, Deusilene Vieira

Journal: Sci Rep

PubMed ID: 37495613

Doi: 10.1038/s41598-023-37756-z

Products & Services: Molecular Biology Reagents

Breakthrough SARS-CoV-2 Omicron Variant in Individuals Primed with Heterologous Vaccines Enhances Inhibition Performance of Neutralizing Antibody to BA2 Parental Lineage

Authors: Jidapa Szekely, Piyawut Swangphon, Natthaphon Nanakorn, Panuttha Chaimuti, Teerapat Nualnoi, Paweena Wongwitwichot, Namchoke Somapa, Denpong Somapa, Theerakamol Pengsakul

Journal: Vaccines (Basel)

PubMed ID: 37515045

Doi: 10.3390/vaccines11071230

Products & Services: Molecular Biology Reagents

Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery

Authors: Natalie S Wallace, John E Gadbery, Cameron I Cohen, Amy K Kendall, Lauren P Jackson

Journal: biorxiv

PubMed ID: 37502979

Doi: 10.1101/2023.07.18.549521

Products & Services: Protein and Antibody Isolation

Spatially-Encoding Hydrogels With DNA to Control Cell Signaling

Authors: Namrata Ramani, C Adrian Figg, Alex J Anderson, Peter H Winegar, EunBi Oh, Sasha B Ebrahimi, Devleena Samanta, Chad A Mirkin

Journal: Adv Mater

PubMed ID: 37221642

Doi: 10.1002/adma.202301086

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Non-canonical function of folate/folate receptor 1 during neural tube formation

Authors: Olga A Balashova, Alexios A Panoutsopoulos, Olesya Visina, Jacob Selhub, Paul S Knoepfler, Laura N Borodinsky

Journal: biorxiv

PubMed ID: 37503108

Doi: 10.1101/2023.07.19.549718

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A Biosafety Study of Human Umbilical Cord Blood Mononuclear Cells Transduced with Adenoviral Vector Carrying Human Vascular Endothelial Growth Factor cDNA In Vitro

Authors: Ilnur I Salafutdinov , Dilara Z Gatina , Maria I Markelova , Ekaterina E Garanina , Sergey Yu Malanin , Ilnaz M Gazizov , Andrei A Izmailov , Albert A Rizvanov , Rustem R Islamov , András Palotás , Zufar Z Safiullov

Journal: Biomedicines .

PubMed ID: 37509661

Doi: 10.3390/biomedicines11072020

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Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses

Authors: Xiuyuan Ou , Ge Xu , Pei Li , Yan Liu , Fuwen Zan , Pan Liu , Jiaxin Hu , Xing Lu , Siwen Dong , Yao Zhou , Zhixia Mu , Zhiqiang Wu , Jianwei Wang , Qi Jin , Pinghuang Liu , Jian Lu , Xiangxi Wang , Zhaohui Qian

Journal: Cell Discov .

PubMed ID: 37507385

Doi: 10.1038/s41421-023-00581-9

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Engineering the HK97 virus-like particle as a nanoplatform for biotechnology applications

Authors: Michael D Woods, Matthew Cali, Bubacarr Ceesay, Shandis Fancher, Gaini Ibrasheva, Suefian Kandeel, Manon Nassar, Ali Azghani, Brent Bill, Dustin P Patterson

Journal: J Mater Chem B

PubMed ID: 37345352

Doi: 10.1039/d3tb00318c

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A neural cell adhesion molecule from oyster Crassostrea gigas: Molecular identification and immune functional characterization

Authors: Xue Qiao, Conghui Liu, Weilin Wang, Chuanyan Yang, Meijia Li, Qilin Yi, Ning Kong, Limei Qiu, Xiyang Liu, Lingling Wang, Linsheng Song

Journal: Int J Biol Macromol

PubMed ID: 37429340

Doi: 10.1016/j.ijbiomac.2023.125756

Products & Services: Protein and Antibody Isolation

Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes

Authors: Shaun K Bremner, Rebecca Berends, Alexandra Kaupisch, Jennifer Roccisana, Calum Sutherland, Nia J Bryant, Gwyn W Gould

Journal: PeerJ

PubMed ID: 37520260

Doi: 10.7717/peerj.15630

Products & Services: Protein and Antibody Isolation

Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues

Authors: Yorick Post, Archana Dilip, Liqin Xie, Asmiti Sura, Nicholas Suen, Jay Ye, Devin Mutha, Angela T Liu, Huy Nguyen, Elizabeth Whisler, Darshini Shah, Shalaka Deshmukh, Navrose Dhaliwal, Ben Bauer, Eskedar Nigatu, Anh Diep, Tom Lopez, Tristan W Fowler, Sung-Jin Lee, Chenggang Lu, Wen-Chen Yeh, Hui Chen, Yang Li

Journal: Cell Chem Biol

PubMed ID: 37413985

Doi: 10.1016/j.chembiol.2023.06.006

Products & Services: Gene Synthesis

An Immunoinformatics-Based Study of Mycobacterium tuberculosis Region of Difference-2 Uncharacterized Protein (Rv1987) as a Potential Subunit Vaccine Candidate for Preliminary Ex Vivo Analysis

Authors: Aregitu Mekuriaw Arega, Ajit Kumar Dhal, Kali Prasad Pattanaik, Sasmita Nayak, Rajani Kanta Mahapatra

Journal: Appl Biochem Biotechnol

PubMed ID: 37498378

Doi: 10.1007/s12010-023-04658-9

Products & Services: Gene Synthesis

Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity

Authors: Ian N Boys, Alex G Johnson, Meghan R Quinlan, Philip J Kranzusch, Nels C Elde

Journal: Cell Rep

PubMed ID: 37494187

Doi: 10.1016/j.celrep.2023.112878

Products & Services: Molecular Biology Reagents

Structural and biochemical characterization of Schlafen11 N-terminal domain

Authors: Pengjiao Hou, Wei Hao, Bo Qin, Mengyun Li, Rong Zhao, Sheng Cui

Journal: Nucleic Acids Res

PubMed ID: 37293979

Doi: 10.1093/nar/gkad509

Products & Services: Gene Synthesis

Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

Authors: Benedikt Goretzki, Christoph Wiedemann, Brett A McCray, Stefan L Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K Donohue, Cy M Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J Sumner, Gerhard Hummer, Ute A Hellmich

Journal: Nat Commun

PubMed ID: 37443299

Doi: 10.1038/s41467-023-39808-4

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Absolute Quantification of Photoreceptor Outer Segment Proteins

Authors: Nikolai P Skiba, Tylor R Lewis, William J Spencer, Carson M Castillo, Andrej Shevchenko, Vadim Y Arshavsky

Journal: J Proteome Res

PubMed ID: 37493966

Doi: 10.1021/acs.jproteome.3c00267

Products & Services: Peptide Synthesis

Computationally Designed Small Molecules Disassemble Both Soluble Oligomers and Protofibrils of Amyloid β-Protein Responsible for Alzheimer's Disease

Authors: Yingying Jin, Matthew A Downey, Ambuj Singh, Steven K Buratto, Michael T Bowers

Journal: ACS Chem Neurosci

PubMed ID: 37442126

Doi: 10.1021/acschemneuro.3c00266

Products & Services: Protein and Antibody Isolation

TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma

Authors: Niranjana Amin, Herui Wang, Qi Song, Manju Bhaskar, Sharda Prasad Yadav, Mark R Gilbert, Harish Pant, Emeline Tabouret, Zhengping Zhuang

Journal: Int J Mol Sci

PubMed ID: 37511490

Doi: 10.3390/ijms241411733

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Structural basis of CXC chemokine receptor 1 ligand binding and activation

Authors: Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R H Tame, Asuka Inoue, Sam-Yong Park

Journal: Nat Commun

PubMed ID: 37433790

Doi: 10.1038/s41467-023-39799-2

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Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Authors: Yi Zhou, Guofei Cui, Hongwei Xu, Joanne Chun, Doris Yang, Zheng Zhang, Lihui Yang, Jingxiao Wang, Meijuan Wan, Diego F Calvisi, Shumei Lin, Xin Chen, Haichuan Wang

Journal: Cell Death Dis

PubMed ID: 37500626

Doi: 10.1038/s41419-023-05958-y

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Class I histone deacetylase complex: Structure and functional correlates

Authors: Xiao Wang, Yannan Wang, Simiao Liu, Yi Zhang, Ke Xu, Liting Ji, Roger D Kornberg, Heqiao Zhang

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 37459529

Doi: 10.1073/pnas.2307598120

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Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results

Authors: Raffit Hassan, Marcus Butler, Roisin E O'Cearbhaill, David Y Oh, Melissa Johnson, Kevin Zikaras, Munisha Smalley, Michael Ross, Janos L Tanyi, Azam Ghafoor, Nirali N Shah, Babak Saboury, Liang Cao, Alfonso Quintás-Cardama, David Hong

Journal: Nat Med

PubMed ID: 37501016

Doi: 10.1038/s41591-023-02452-y

Products & Services: Protein and Antibody Isolation

Combined Inhibition of the TGF-β1/Smad Pathway by and to Reduce Inflammation and Fibrosis in Primary Sclerosing Cholangitis

Authors: Yu Shen, Baorong Jiang, Chenchen Zhang, Qian Wu, Lei Li, Ping Jiang

Journal: Int J Mol Sci

PubMed ID: 37446187

Doi: 10.3390/ijms241311010

Products & Services: Protein and Antibody Isolation

Perdeuterated GbpA Enables Neutron Scattering Experiments of a Lytic Polysaccharide Monooxygenase

Authors: H V Sørensen, Mateu Montserrat-Canals, Jennifer S M Loose, S Zoë Fisher, Martine Moulin, Matthew P Blakeley, Gabriele Cordara, Kaare Bjerregaard-Andersen, Ute Krengel

Journal: ACS Omega

PubMed ID: 37599915

Doi: 10.1021/acsomega.3c02168

Products & Services: Protein and Antibody Isolation

Viral manipulation of cell polarity signalling

Authors: Airah Javorsky, Patrick O Humbert, Marc Kvansakul

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 37437846

Doi: 10.1016/j.bbamcr.2023.119536

Products & Services: Molecular Biology Reagents

Immunogenicity and safety of inactivated SARS-CoV-2 vaccine in haemodialysis patients: a prospective cohort study

Authors: Metalia Puspitasari, Prenali D Sattwika, Dzerlina S Rahari, Wynne Wijaya, Auliana R P Hidayat, Nyoman Kertia, Bambang Purwanto, Jarir At Thobari

Journal: Sci Rep

PubMed ID: 37463975

Doi: 10.1038/s41598-023-38628-2

Products & Services: Molecular Biology Reagents

The combination of osimertinib with Raf inhibitor overcomes osimertinib resistance induced by KRAS amplification in EGFR-mutated lung cancer cells

Authors: Tae-Gul Lee, Hye-Min Kang, Seo Yun Kim, Hye-Ryoun Kim, Cheol Hyeon Kim

Journal: Exp Cell Res

PubMed ID: 37442265

Doi: 10.1016/j.yexcr.2023.113722

Products & Services: Protein and Antibody Isolation

Targeting CXCR4-expressing Cancer Cells with Avidin-poly (lactic-co-glycolic acid) Nanoparticle Surface Modified with Biotinylated DV1 Peptide

Authors: Shiba Ansari, Madeeha Mudassir, B Vijayalekshmi, Parthaprasad Chattopadhyay

Journal: Int J Appl Basic Med Res

PubMed ID: 37614837

Doi: 10.4103/ijabmr.ijabmr_58_23

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Notch Intracellular Domains form Transcriptionally Active Heterodimeric Complexes on Sequence-paired Sites

Authors: Tana R Gazdik, Jacob J Crow, Tyler Lawton, Chloe J Munroe, Hannah Theriault, Travis M Wood, Allan R Albig

Journal: Res Sq

PubMed ID: 37546896

Doi: 10.21203/rs.3.rs-3147210/v1

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Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Authors: Eva-Maria Thüring, Christian Hartmann, Janesha C Maddumage, Airah Javorsky, Birgitta E Michels, Volker Gerke, Lawrence Banks, Patrick O Humbert, Marc Kvansakul, Klaus Ebnet

Journal: Commun Biol

PubMed ID: 37430142

Doi: 10.1038/s42003-023-05088-3

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Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis

Authors: Aleksandra W Debowski, Nicole M Bzdyl, David R Thomas, Nichollas E Scott, Christopher H Jenkins, Jua Iwasaki, Emily A Kibble, Chen Ai Khoo, Nicolas J Scheuplein, Pamela M Seibel, Theresa Lohr, Georgie Metters, Charles S Bond, Isobel H Norville, Keith A Stubbs, Nicholas J Harmer, Ulrike Holzgrabe, Hayley J Newton, Mitali Sarkar-Tyson

Journal: PLoS Pathog

PubMed ID: 37399210

Doi: 10.1371/journal.ppat.1011491

Products & Services: Protein and Antibody Isolation

Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins

Authors: Ashley P Viera Ortiz, Gregory Cajka, Olamide A Olatunji, Bailey Mikytuck, Ophir Shalem, Edward B Lee

Journal: Brain

PubMed ID: 36516294

Doi: 10.1093/brain/awac479

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Investigating the aggregation perspective of Dengue virus proteome

Authors: Shivani Krishna Kapuganti, Kumar Udit Saumya, Deepanshu Verma, Rajanish Giri

Journal: Virology

PubMed ID: 37473502

Doi: 10.1016/j.virol.2023.07.010

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N6-Methyladenosine Promotes Translation of VEGFA to Accelerate Angiogenesis in Lung Cancer

Authors: Haisheng Zhang, Jiawang Zhou, Jiexin Li, Zhaotong Wang, Zhuojia Chen, Ziyan Lv, Lichen Ge, Guoyou Xie, Guoming Deng, Yalan Rui, Hongbing Huang, Likun Chen, Hongsheng Wang

Journal: Cancer Res

PubMed ID: 37103476

Doi: 10.1158/0008-5472.CAN-22-2449

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Purification and characterization of human glycerol 3-phosphate dehydrogenases (mitochondrial and cytosolic) by NAD/NADH redox method

Authors: Superior Syngkli, Bidyadhar Das

Journal: Biochimie

PubMed ID: 37481063

Doi: 10.1016/j.biochi.2023.07.015

Products & Services: Molecular Biology Reagents

A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

Authors: Yingjia Yao, Yunhan Zhang, Zexu Li, Zhisong Chen, Xiaofeng Wang, Zihan Li, Li Yu, Xiaolong Cheng, Wei Li, Wen-Jie Jiang, Hua-Jun Wu, Zezhong Feng, Jinfu Sun, Teng Fei

Journal: Biochem Biophys Res Commun

PubMed ID: 37467664

Doi: 10.1016/j.bbrc.2023.07.018

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Interspersed expression of CUP-SHAPED COTYLEDON2 and REDUCED COMPLEXITY shapes Cardamine hirsuta complex leaf form

Authors: Neha Bhatia, David Wilson-Sánchez, Sören Strauss, Francesco Vuolo, Bjorn Pieper, Ziliang Hu, Léa Rambaud-Lavigne, Miltos Tsiantis

Journal: Curr Biol

PubMed ID: 37453425

Doi: 10.1016/j.cub.2023.06.037

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Monitoring SARS-CoV-2 variants in wastewater of Dhaka City, Bangladesh: approach to complement public health surveillance systems

Authors: Rehnuma Haque, Mohammad Enayet Hossain, Mojnu Miah, Mahbubur Rahman, Nuhu Amin, Ziaur Rahman, Md Shariful Islam, Mohammed Ziaur Rahman

Journal: Hum Genomics

PubMed ID: 37420264

Doi: 10.1186/s40246-023-00505-4

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Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense

Authors: Rui Cheng , Fengtao Huang , Xueling Lu , Yan Yan , Bingbing Yu , Xionglue Wang , Bin Zhu

Journal: Cell Host Microbe .

PubMed ID: 37480847

Doi: 10.1016/j.chom.2023.06.014

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Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

Authors: Shiqun Wang , Wei Yan, Lingkai Kong , Shuguang Zuo , Jingyi Wu, Chunxiao Zhu , Huaping Huang , Bohao He, Jie Dong, Jiwu Wei

Journal: Nat Commun .

PubMed ID: 37474548

Doi: 10.1038/s41467-023-39683-z

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Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS–STING pathway

Authors: Jing An , Chuan-Ping Zhang , Hou-Yuan Qiu , Hong-Xia Zhang , Qiu-Bing Chen , Yu-Ming Zhang , Xin-Lin Lei , Cai-Xiang Zhang , Hao Yin , Ying Zhang

Journal: Nat Biomed Eng .

PubMed ID: 37500747

Doi: 10.1038/s41551-023-01073-7

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Enhanced Carotenoid Production in Chlamydomonas reinhardtii via Overexpression of Endogenous and Exogenous Beta-Carotene Ketolase (BKT) Genes

Authors: Yuanhao Chen , Hong Du , Honghao Liang , Ting Hong , Tangcheng Li

Journal: Int J Mol Sci .

PubMed ID: 37511141

Doi: 1422-0067/24/14/11382

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Pathogenic CANVAS (AAGGG) repeats stall DNA replication due to the formation of alternative DNA structures

Authors: Julia A Hisey, Elina A Radchenko, Silvia Ceschi, Anastasia Rastokina, Nicholas H Mandel, Ryan J McGinty, Gabriel Matos-Rodrigues, Alfredo Hernandez, André Nussenzweig, Sergei M Mirkin

Journal: biorxiv

PubMed ID: 37546920

Doi: 10.1101/2023.07.25.550509

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Integrated immunoinformatics and subtractive proteomics approach for multi-epitope vaccine designing to combat TIGR4

Authors: Sami S Ashgar, Hani Faidah, Farkad Bantun, Naif A Jalal, Naeem F Qusty, Abdulla Darwish, Shafiul Haque, Essam M Janahi

Journal: Front Mol Biosci

PubMed ID: 37560463

Doi: 10.3389/fmolb.2023.1212119

Products & Services: Protein and Antibody Isolation

Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants

Authors: Ebene R Haycroft, Samantha K Davis, Pradhipa Ramanathan, Ester Lopez, Ruth A Purcell, Li Lynn Tan, Phillip Pymm, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Jennifer A Juno, Samuel J Redmond, Nicholas A Gherardin, Dale I Godfrey, Wai-Hong Tham, Kevin John Selva, Stephen J Kent, Amy W Chung

Journal: Med Microbiol Immunol

PubMed ID: 37477828

Doi: 10.1007/s00430-023-00773-w

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Effectors of the Type VI Secretion System Have the Potential to Be Modified into Antimicrobial Peptides

Authors: Wenjia Lu, Hao Lu, Chenchen Wang, Gaoyan Wang, Wenqi Dong, Chen Tan

Journal: Microbiol Spectr

PubMed ID: 37470717

Doi: 10.1128/spectrum.00308-23

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Long Non-coding RNA LINC00342 Promotes the Proliferation, Invasion, and Migration of Primary Hepatocellular Carcinoma Cells by Regulating the Expression of miRNA-19a-3p, miRNA-545-5p, and miRNA-203a-3p

Authors: Zong-Xi Yao, Jun-Hao Tu, Yu-Lin Liu, Xiao-Feng Xue, Lei Qin