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Long Non-coding RNA LINC00342 Promotes the Proliferation, Invasion, and Migration of Primary Hepatocellular Carcinoma Cells by Regulating the Expression of miRNA-19a-3p, miRNA-545-5p, and miRNA-203a-3p

Authors: Zong-Xi Yao, Jun-Hao Tu, Yu-Lin Liu, Xiao-Feng Xue, Lei Qin

Journal: Biochem Genet

PubMed ID: 37395850

Doi: 10.1007/s10528-023-10420-x

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Generation of Bioactive Peptides from sp and Assessment of Their Potential for Use in the Prevention of Hypertension, Inflammation and Pain

Authors: Maria Hayes, Rotimi E Aluko, Elena Aurino, Leticia Mora

Journal: Mar Drugs

PubMed ID: 37623703

Doi: 10.3390/md21080422

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A bistable autoregulatory module in the developing embryo commits cells to binary expression fates

Authors: Jiaxi Zhao, Mindy Liu Perkins, Matthew Norstad, Hernan G Garcia

Journal: Curr Biol

PubMed ID: 37453424

Doi: 10.1016/j.cub.2023.06.060

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Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G

Authors: Takahide Kouno, Satoshi Shibata, Megumi Shigematsu, Jaekyung Hyun, Tae Gyun Kim, Hiroshi Matsuo, Matthias Wolf

Journal: Nat Commun

PubMed ID: 37419875

Doi: 10.1038/s41467-023-39796-5

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Fusion of Substrate-Binding Domains Enhances the Catalytic Capacity of Keratinases and Promotes Enzymatic Conversion of Feather Waste

Authors: Xiaomei Ji, Zheng Peng, Jie Song, Guoqiang Zhang, Juan Zhang

Journal: J Agric Food Chem

PubMed ID: 37462367

Doi: 10.1021/acs.jafc.3c03064

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An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles

Authors: Huanhuan Li, Yixi Wu, Minke Li, Lu Guo, Yaqi Gao, Quan Wang, Jihua Zhang, Zhaohua Lai, Xing Zhang, Lixin Zhu, Ping Lan, Zihe Rao, Yingfang Liu, Huanhuan Liang

Journal: Nat Struct Mol Biol

PubMed ID: 37488357

Doi: 10.1038/s41594-023-01043-2

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The combined action of the intracellular regions regulates FGFR2 kinase activity

Authors: Chi-Chuan Lin , Lukasz Wieteska , Guillaume Poncet-Montange , Kin Man Suen , Stefan T Arold , Zamal Ahmed , John E Ladbury

Journal: Commun Biol .

PubMed ID: 37452126

Doi: 10.1038/s42003-023-05112-6

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Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins

Authors: Haolan Wang , Ming Guo , Hudie Wei , Yongheng Chen

Journal: Comput Struct Biotechnol J .

PubMed ID: 37560128

Doi: 10.1016/j.csbj.2023.07.017

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Development of miniature base editors using engineered IscB nickase

Authors: Dingyi Han , Qingquan Xiao , Yifan Wang , Hainan Zhang , Xue Dong , Guoling Li , Xiangfeng Kong , Shihao Wang , Jinhui Song , Weihong Zhang , Jingxing Zhou , Lanting Bi , Yuan Yuan , Linyu Shi , Na Zhong , Hui Yang , Yingsi Zhou

Journal: Nat Methods .

PubMed ID: 37231266

Doi: 10.1038/s41592-023-01898-9

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Manganese-based microcrystals equipped with Ythdf1-targeted biomimeticnanovaccines for reinforced dendritic cell spatiotemporal orchestration

Authors: Feng Liu , Lulu Tan, Zheng Dai , Yang Wang , Lei Huang , Yang Zhang , Qian Cheng , Xin Li , Miao-Deng Liu, Lin Wang, Zheng Wang

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102112

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Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration

Authors: Xian Xie ， Zhuo Li , Xuefeng Yang , Boguang Yang , Zhixian Zong , Xuemei Wang , Liting Duan , Sien Lin , Gang Li , Liming Bian

Journal: J Am Chem Soc

PubMed ID: 37428960

Doi: 10.1021/jacs.3c02210

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Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Authors: Jay C Groppe, Guorong Lu, Mary R Tandang-Silvas, Anupama Pathi, Shruti Konda, Jingfeng Wu, Viet Q Le, Andria L Culbert, Eileen M Shore, Kristi A Wharton, Frederick S Kaplan

Journal: Biomolecules

PubMed ID: 37509165

Doi: 10.3390/biom13071129

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TLR5S negatively regulates the TLR5M-mediated NF-κB signaling pathway in Epinephelus coioides

Authors: Liangge He, Xue Yu, Yulin Zhao, Haoran Lin, Yong Zhang, Danqi Lu

Journal: Int J Biol Macromol

PubMed ID: 37517756

Doi: 10.1016/j.ijbiomac.2023.126048

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Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays

Authors: Rui Qing, Mantian Xue, Jiayuan Zhao, Lidong Wu, Andreas Breitwieser, Eva Smorodina, Thomas Schubert, Giovanni Azzellino, David Jin, Jing Kong, Tomás Palacios, Uwe B Sleytr, Shuguang Zhang

Journal: Sci Adv

PubMed ID: 37478177

Doi: 10.1126/sciadv.adf1402

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An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma

Authors: Akinsola Oyelakin, Jennifer Sosa, Kasturi Bala Nayak, Alexandra Glathar, Christian Gluck, Isha Sethi, Maria Tsompana, Norma Nowak, Michael Buck, Rose-Anne Romano, Satrajit Sinha

Journal: NAR Cancer

PubMed ID: 37492374

Doi: 10.1093/narcan/zcad038

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Peptide/Nanoparticle Biointerfaces for Multistep Tandem Catalysis

Authors: Yuliana Perdomo, Joseph M Slocik, David M Phillips, Marc R Knecht

Journal: J Am Chem Soc

PubMed ID: 37478168

Doi: 10.1021/jacs.3c04097

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Transcriptomic analysis of hepatocytes reveals the association between ubiquitin-specific peptidase 1 and yes-associated protein 1 during liver regeneration

Authors: Yalei Zhao, Fen Zhang, Xiaoli Zhang, Zuhong Li, Qian Li, Tianzhi Ni, Ruojing Wang, Liangru Liu, Yingli He, Yingren Zhao

Journal: Regen Ther

PubMed ID: 37534236

Doi: 10.1016/j.reth.2023.07.004

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Ice Recrystallization Inhibition Activity of Soy Protein Hydrolysates

Authors: Madison Fomich, Vermont P Día, Uvinduni I Premadasa, Benjamin Doughty, Hari B Krishnan, Tong Wang

Journal: J Agric Food Chem

PubMed ID: 37466256

Doi: 10.1021/acs.jafc.2c08701

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Tumor Site-Specific Cleavage Improves the Antitumor Efficacy of Antibody-Drug Conjugates

Authors: Keyuan Xu, Jiani Han, Liu Yang, Li Cao, Shuang Li, Zhangyong Hong

Journal: Int J Mol Sci

PubMed ID: 37446189

Doi: 10.3390/ijms241311011

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Author Correction: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

Authors: Corey Momont, Ha V Dang, Fabrizia Zatta, Kevin Hauser, Caihong Wang, Julia di Iulio, Andrea Minola, Nadine Czudnochowski, Anna De Marco, Kaitlin Branch, David Donermeyer, Siddhant Vyas, Alex Chen, Elena Ferri, Barbara Guarino, Abigail E Powell, Roberto Spreafico, Samantha S Yim, Dale R Balce, Istvan Bartha, Marcel Meury, Tristan I Croll, David M Belnap, Michael A Schmid, William Timothy Schaiff, Jessica L Miller, Elisabetta Cameroni, Amalio Telenti, Herbert W Virgin, Laura E Rosen, Lisa A Purcell, Antonio Lanzavecchia, Gyorgy Snell, Davide Corti, Matteo Samuele Pizzuto

Journal: Nature

PubMed ID: 37407829

Doi: 10.1038/s41586-023-06385-x

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Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment

Authors: Derek Allen, Samerender Nagam Hanumantharao, Rylie McDonell, Karen-Amanda Irvine, Peyman Sahbaie, David Clark, Paul Blum

Journal: Sci Rep

PubMed ID: 37479740

Doi: 10.1038/s41598-023-38618-4

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Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays

Authors: So Jin Bing, Stephanee Warrington, Ronit Mazor

Journal: Front Immunol

PubMed ID: 37469509

Doi: 10.3389/fimmu.2023.1211529

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Systemic delivery of specific and efficient CRISPR/Cas9 system targeting HPV16 oncogenes using LL-37 antimicrobial peptide in C57BL/6 mice

Authors: Niloofar Khairkhah, Azam Bolhassani, Farzad Rajaei, Reza Najafipour

Journal: J Med Virol

PubMed ID: 37403986

Doi: 10.1002/jmv.28934

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A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury

Authors: Chen Yang, Huidie Xu, Dong Yang, Yunhao Xie, Mingrui Xiong, Yu Fan, XiKai Liu, Yu Zhang, Yushuo Xiao, Yuchen Chen, Yihao Zhou, Liangliang Song, Chen Wang, Anlin Peng, Robert B Petersen, Hong Chen, Kun Huang, Ling Zheng

Journal: Nat Commun

PubMed ID: 37460623

Doi: 10.1038/s41467-023-40036-z

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The structure and mechanism of action of a distinct class of dicistrovirus intergenic region IRESs

Authors: Irina S Abaeva , Christina Young , Reid Warsaba , Nadiyah Khan , Lan Vy Tran , Eric Jan , Tatyana V Pestova , Christopher U T Hellen

Journal: Nucleic Acids Res .

PubMed ID: 37427788

Doi: 10.1093/nar/gkad569

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Network pharmacology, molecular docking and experimental verification of the mechanism of huangqi-jixuecao herb pair in treatment of peritoneal fibrosis

Authors: Huibo Dai , Yun Shan , Manshu Yu ， Funing Wang , Ziren Zhou , Jinyi Sun , Li Sheng , Liyan Huang , Meixiao Sheng

Journal: J Ethnopharmacol .

PubMed ID: 37437794

Doi: 10.1016/j.jep.2023.116874

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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Authors: Hudie Wei , Haolan Wang , Genxin Wang , Lingzhi Qu , Longying Jiang , Shuyan Dai , Xiaojuan Chen , Ye Zhang , Zhuchu Chen , Youjun Li , Ming Guo , Yongheng Chen

Journal: Nat Commun .

PubMed ID: 37463921

Doi: 10.1038/s41467-023-40087-2

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The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization

Authors: Melissa S Traver , Bonnie Bartel

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 37410814

Doi: 10.1073/pnas.2304870120

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Unravelling the Therapeutic Potential of Antibiotics in Hypoxia in a Breast Cancer MCF-7 Cell Line Model

Authors: Almaz A Akhunzianov , Alfiya I Nesterova , Sjoerd Wanrooij , Yulia V Filina , Albert A Rizvanov , Regina R Miftakhova

Journal: Int J Mol Sci .

PubMed ID: 37511298

Doi: 10.3390/ijms241411540

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A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity

Authors: Mingfeng Zhang , Yuanyue Shan , Charles D Cox , Duanqing Pei

Journal: Nat Commun .

PubMed ID: 37402734

Doi: 10.1038/s41467-023-39688-8

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Siglec15 promotes the migration of thyroid carcinoma cells by enhancing the EGFR protein stability

Authors: Sijing Huang, Zhi Ji, Jinqiang Xu, Yuerong Yang, BingRui Wu, Qihang Chen, Shuting Geng, Yu Si, Jiayue Chen, Yuanyan Wei, Cong Wang, Zhilong Ai, Jianhai Jiang

Journal: Glycobiology

PubMed ID: 37129515

Doi: 10.1093/glycob/cwad037

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Caspase-mediated LPS sensing and pyroptosis signaling in

Authors: Shouwen Chen, Shuxin Li, Hao Chen, Yuxin Gong, Dahai Yang, Yuanxing Zhang, Qin Liu

Journal: Sci Adv

PubMed ID: 37478191

Doi: 10.1126/sciadv.adh4054

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Systematic investigation on the multi-scale mechanisms of bitter peptide self-assembly for flavor modulation

Authors: Rong Zhang, Wei Jia

Journal: Food Chem

PubMed ID: 37541037

Doi: 10.1016/j.foodchem.2023.137063

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Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

Authors: Camille N Pierre, Lily E Adams, Kara Anasti, Derrick Goodman, Sherry Stanfield-Oakley, John M Powers, Dapeng Li, Wes Rountree, Yunfei Wang, Robert J Edwards, S Munir Alam, Guido Ferrari, Georgia D Tomaras, Barton F Haynes, Ralph S Baric, Kevin O Saunders

Journal: biorxiv

PubMed ID: 37546738

Doi: 10.1101/2023.07.25.550460

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Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States

Authors: Aijing Feng, Sarah Bevins, Jeff Chandler, Thomas J DeLiberto, Ria Ghai, Kristina Lantz, Julianna Lenoch, Adam Retchless, Susan Shriner, Cynthia Y Tang, Suxiang Sue Tong, Mia Torchetti, Anna Uehara, Xiu-Feng Wan

Journal: Nat Commun

PubMed ID: 37429851

Doi: 10.1038/s41467-023-39782-x

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A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation

Authors: Karla Wolf, Jan Kosinski, Toby J Gibson, Nicole Wesch, Volker Dötsch, Maurizio Genuardi, Emanuela Lucci Cordisco, Stefan Zeuzem, Angela Brieger, Guido Plotz

Journal: Nucleic Acids Res

PubMed ID: 37224528

Doi: 10.1093/nar/gkad418

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Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data

Authors: Brittany Cain, Jordan Webb, Zhenyu Yuan, David Cheung, Hee-Woong Lim, Rhett A Kovall, Matthew T Weirauch, Brian Gebelein

Journal: Nucleic Acids Res

PubMed ID: 37114997

Doi: 10.1093/nar/gkad318

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Increase in SARS-CoV-2 Seroprevalence in UK Domestic Felids Despite Weak Immunogenicity of Post-Omicron Variants

Authors: Grace B Tyson, Sarah Jones, Chloe Montreuil-Spencer, Nicola Logan, Sam Scott, Hagar Sasvari, Michael McDonald, Leigh Marshall, Pablo R Murcia, Brian J Willett, William Weir, Margaret J Hosie

Journal: Viruses

PubMed ID: 37632004

Doi: 10.3390/v15081661

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Functionally diverse front-end desaturases are widespread in the phylum Annelida

Authors: Marc Ramos-Llorens, Francisco Hontoria, Juan C Navarro, David E K Ferrier, Óscar Monroig

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 37517549

Doi: 10.1016/j.bbalip.2023.159377

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A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer

Authors: Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius, Wijnand Helfrich

Journal: Cancers (Basel)

PubMed ID: 37509310

Doi: 10.3390/cancers15143651

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Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors

Authors: Gabriel Espinosa-Carrasco, Aurora Scrivo, Paul Zumbo, Asim Dave, Doron Betel, Matthew Hellmann, Bryan M Burt, Hyun-Sung Lee, Andrea Schietinger

Journal: biorxiv

PubMed ID: 37461721

Doi: 10.1101/2023.07.03.547423

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Establishment and characterization of an SV40 immortalized chicken intestinal epithelial cell line

Authors: Federico Ghiselli, Martina Felici, Andrea Piva, Ester Grilli

Journal: Poult Sci

PubMed ID: 37517361

Doi: 10.1016/j.psj.2023.102864

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Probing Substrate Transport Effects on Enzymatic Hydrogen Catalysis: An Alternative Proton Transfer Pathway in Putatively Sensory [FeFe] Hydrogenase

Authors: Princess R Cabotaje, Kaija Walter, Afridi Zamader, Ping Huang, Felix Ho, Henrik Land, Moritz Senger, Gustav Berggren

Journal: ACS Catal

PubMed ID: 37560193

Doi: 10.1021/acscatal.3c02314

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Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site

Authors: Theresa L Simermeyer, Stephanie Batalis, LeAnn C Rogers, Owen J Zalesak, Thomas Hollis

Journal: Nucleic Acids Res

PubMed ID: 37246644

Doi: 10.1093/nar/gkad447

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Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer

Authors: Apostolia M Tsimberidou, Kerstin Guenther, Borje S Andersson, Regina Mendrzyk, Amir Alpert, Claudia Wagner, Anna Nowak, Katrin Aslan, Arun Satelli, Fabian Richter, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Zoe Coughlin, Ali S Mohamed, Kerry Sieger, Becky Norris, Rita Ort, Jennifer Beck, Henry Hiep Vo, Franziska Hoffgaard, Manuel Ruh, Linus Backert, Ignacio I Wistuba, David Fuhrmann, Nuhad K Ibrahim, Van Karlyle Morris, Bryan K Kee, Daniel M Halperin, Graciela M Nogueras-Gonzalez, Partow Kebriaei, Elizabeth J Shpall, David Vining, Patrick Hwu, Harpreet Singh, Carsten Reinhardt, Cedrik M Britten, Norbert Hilf, Toni Weinschenk, Dominik Maurer, Steffen Walter

Journal: Cancer Immunol Res

PubMed ID: 37172100

Doi: 10.1158/2326-6066.CIR-22-0444

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Antibody binding of amyloid beta peptide epimers/isomers and ramifications for immunotherapies and drug development

Authors: Elizabeth R Readel, Arzoo Patel, Joshua I Putman, Siqi Du, Daniel W Armstrong

Journal: Sci Rep

PubMed ID: 37524807

Doi: 10.1038/s41598-023-38788-1

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Author Correction: Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses

Authors: Fredrika Hellgren, Alberto Cagigi, Rodrigo Arcoverde Cerveira, Sebastian Ols, Theresa Kern, Ang Lin, Bengt Eriksson, Michael G Dodds, Edith Jasny, Kim Schwendt, Conrad Freuling, Thomas Müller, Martin Corcoran, Gunilla B Karlsson Hedestam, Benjamin Petsch, Karin Loré

Journal: Nat Commun

PubMed ID: 37429868

Doi: 10.1038/s41467-023-39754-1

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PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in β cells in vitro under stress conditions

Authors: Zixuan Li, Yijun Lin, Shixuan Zhuo, Jinzhu Chen, Lingling Chen, Shuying Wang, Yan Chen

Journal: Mol Cell Endocrinol

PubMed ID: 37499998

Doi: 10.1016/j.mce.2023.112032

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Systematic analysis of the impact of phosphorylation and O-GlcNAcylation on protein subcellular localization

Authors: Senhan Xu, Suttipong Suttapitugsakul, Ming Tong, Ronghu Wu

Journal: Cell Rep

PubMed ID: 37453062

Doi: 10.1016/j.celrep.2023.112796

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Cell targeting and immunostimulatory properties of a novel Fcγ-receptor-independent agonistic anti-CD40 antibody in rhesus macaques

Authors: Xianglei Yan, Sebastian Ols, Rodrigo Arcoverde Cerveira, Klara Lenart, Fredrika Hellgren, Kewei Ye, Alberto Cagigi, Marcus Buggert, Falk Nimmerjahn, Jesper Falkesgaard Højen, Daniel Parera, Ulrich Pessara, Stephan Fischer, Karin Loré

Journal: Cell Mol Life Sci

PubMed ID: 37353664

Doi: 10.1007/s00018-023-04828-2

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