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The effector Vm1G-1794 protects the aggregated MdEF-Tu from autophagic degradation to promote infection in apple
Authors: Runmin Che, Changhai Liu, Qi Wang, Wenyan Tu, Ping Wang, Chao Li, Xiaoqing Gong, Ke Mao, Hao Feng, Lili Huang, Pengmin Li, Fengwang Ma
Journal: Autophagy
PubMed ID: 36449354
Doi: 10.1080/15548627.2022.2153573
Tissue replication and mucosal swab detection of Sosuga virus in Syrian hamsters in the absence of overt tissue pathology and clinical disease
Authors: Stephen R Welch, Jana M Ritter, Amy J Schuh, Sarah C Genzer, Teresa E Sorvillo, Jessica R Harmon, JoAnn D Coleman-McCray, Shilpi Jain, Punya Shrivastava-Ranjan, Josilene Nascimento Seixas, Lindsey B Estetter, Pamela S Fair, Jonathan S Towner, Joel M Montgomery, César G Albariño, Christina F Spiropoulou, Jessica R Spengler
Journal: Antiviral Res
PubMed ID: 36521633
Doi: 10.1016/j.antiviral.2022.105490
Roles of the transcriptional regulators Fts1, YlNrg1, YlTup1, and YlSsn6 in the repression of the yeast-to-filament transition in the dimorphic yeast Yarrowia lipolytica
Authors: Yi-Sheng Mao, Jia-Wen Chen, Zhen-Hua Wang, Meng-Yang Xu, Xiang-Dong Gao
Journal: Mol Microbiol
PubMed ID: 36537557
Doi: 10.1111/mmi.15017
Products & Services: Molecular Biology Reagents   
Functional recovery of myocardial infarction by specific EBP-PR1P peptides bridging injectable cardiac extracellular matrix and vascular endothelial growth factor
Authors: Wenxuan Cao, Hong Zhang, Ning Zhou, Runxue Zhou, Xiaojing Zhang, Jia Yin, Jin Deng, Xiang Ao, Chunying Shi
Journal: J Biomed Mater Res A
PubMed ID: 36579729
Doi: 10.1002/jbm.a.37483
Products & Services: Peptide Synthesis   
Cadmium chloride exposure impairs the growth and behavior of Drosophila via ferroptosis
Authors: Yingxia Hu, Haijie Wu, Chenying Lu, Hanqing Xu, Boyang Li, Wanchun Guan, Mingjiang Wu, Yitian Gao, Haibin Tong
Journal: Sci Total Environ
PubMed ID: 36581278
Doi: 10.1016/j.scitotenv.2022.161183
Products & Services: Molecular Biology Reagents   
Polymyxin B neutralizes endotoxin and improves the quality of chicken semen during liquid storage
Authors: Ei Ei Win Maung, Pangda Sopha Sushadi, Atsushi Asano
Journal: Theriogenology
PubMed ID: 36577162
Doi: 10.1016/j.theriogenology.2022.12.027
Products & Services: Molecular Biology Reagents   
Electrical stimulation of piezoelectric BaTiO3 coated Ti6Al4V scaffolds promote antiinflammatory polarization of macrophage and bone repair via MAPK/JNK inhibition and OXPHOS activation
Authors: Hao Wu, Dong Hui, Zhen Tang, Yu Chen, Yichao Liu, Mo Wang, Xinghui Wei, Ning Wang, Shusen Bao, Dongmei Yu, Zhigang Wu, Zhenda Yang, Xiaokang Li, Zheng Guo, Lei Shi
Journal: Biomaterials
Doi: 10.1016/j.biomaterials.2022.121990
mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum
Authors: Clifford T H Hayashi , Yi Cao , Leor C Clark , Abhai K Tripathi , Fidel Zavala , Garima Dwivedi , James Knox , Mohamad-Gabriel Alameh , Paulo J C Lin , Ying K Tam , Drew Weissman , Nirbhay Kumar
Journal: NPJ Vaccines
PubMed ID: 36456563
Doi: 10.1038/s41541-022-00577-8
Products & Services: Codon Optimization   
LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway
Authors: Uttam Sharma, Manjit Kaur Rana, Karuna Singh, Aklank Jain
Journal: Biochem Pharmacol
PubMed ID: 36493845
Doi: 10.1016/j.bcp.2022.115372
Products & Services: Molecular Biology Reagents   
A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor
Authors: Rongbin Wang , Jennifer Nguyen , Jacob Hecht , Nora Schwartz , Katelyn V Brown , Larissa V Ponomareva, Magdalena Niemczura , Dino van Dissel , Gilles P van Wezel , Jon S Thorson, Mikko Metsä-Ketelä , Khaled A Shaaban, S Eric Nybo
Journal: ACS Synth Biol
PubMed ID: 36378506
Doi: 10.1021/acssynbio.2c00498
Products & Services: Gene Synthesis   
An epitope-directed selection strategy facilitating the identification of Frizzled receptor selective antibodies
Authors: Qiangqiang Ge, Maikun Teng, Xu Li, Qiong Guo, Yuyong Tao
Journal: Structure
PubMed ID: 36513066
Doi: 10.1016/j.str.2022.11.009
DNA-protein cross-links between abasic DNA damage and mitochondrial transcription factor A (TFAM)
Authors: Wenyan Xu , Jin Tang , Linlin Zhao
Journal: Nucleic Acids Res
PubMed ID: 36583367
Doi: 10.1093/nar/gkac1214
Products & Services: Catalog Antibody   
Discovery of antibodies and cognate surface targets for ovarian cancer by surface profiling
Authors: Bärbel Schröfelbauer, Patrick K Kimes, Paige Hauke, Charlotte E Reid, Kevin Shao, Sarah J Hill, Rafael Irizarry, William C Hahn
Journal: Proc Natl Acad Sci U S A
PubMed ID: 36574667
Doi: 10.1073/pnas.2206751120
Principles of mitoribosomal small subunit assembly in eukaryotes
Authors: Nathan J Harper, Chloe Burnside, Sebastian Klinge
Journal: Nature
PubMed ID: 36482135
Doi: 10.1038/s41586-022-05621-0
Products & Services: Gene Synthesis   
Antibody Response of Heterologous vs Homologous Messenger RNA Vaccine Boosters Against the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant: Interim Results from the PRIBIVAC Study, a Randomized Clinical Trial
Authors: Xuan Ying Poh, Chee Wah Tan, I Russel Lee, Jean-Marc Chavatte, Siew-Wai Fong, Tessa Prince, Catherine Hartley, Aileen Y Y Yeoh, Suma Rao, Po Ying Chia, Sean W X Ong, Tau Hong Lee, Sapna P Sadarangani, Ray J H Lin, Clarissa Lim, Jefanie Teo, Daniel R X Lim, Wanni Chia, Julian A Hiscox, Lisa F P Ng, Ee Chee Ren, Raymond T P Lin, Laurent Renia, David Chien Lye, Lin-Fa Wang, Barnaby E Young
Journal: Clin Infect Dis
PubMed ID: 35543372
Doi: 10.1093/cid/ciac345
Products & Services: Recombinant Proteins   
Early TNF-Dependent Regulation of Excitatory and Inhibitory Synapses on Striatal Direct Pathway Medium Spiny Neurons in the YAC128 Mouse Model of Huntington's Disease
Authors: Julien Chambon, Pragya Komal, Gil M Lewitus, Gina M Kemp, Simone Valade, Houaria Adaïdi, Noura Al Bistami, David Stellwagen
Journal: J Neurosci
PubMed ID: 36517241
Doi: 10.1523/JNEUROSCI.1655-22.2022
Products & Services: Molecular Biology Reagents   
Long-Term Adaptation to Galactose as a Sole Carbon Source Selects for Mutations Outside the Canonical GAL Pathway
Authors: Artemiza A Martínez, Andrew Conboy, Sean W Buskirk, Daniel A Marad, Gregory I Lang
Journal: J Mol Evol
PubMed ID: 36482210
Doi: 10.1007/s00239-022-10079-9
Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine
Authors: Sara Caxaria, Nikolaos Kouvatsos, Suzanne E Eldridge, Mario Alvarez-Fallas, Anne-Sophie Thorup, Daniela Cici, Aida Barawi, Ammaarah Arshed, Danielle Strachan, Giulia Carletti, Xinying Huang, Sabah Bharde, Melody Deniz, Jacob Wilson, Bethan L Thomas, Costantino Pitzalis, Francesco Paolo Cantatore, Manasi Sayilekshmy, Shafaq Sikandar, Frank P Luyten, Thomas Pap, Joanna C Sherwood, Anthony J Day, Francesco Dell'Accio
Journal: EMBO Mol Med
PubMed ID: 36507558
Doi: 10.15252/emmm.202216218
Products & Services: Molecular Biology Reagents   
Comment on: Identification of a novel tedizolid resistance mutation in rpoB of MRSA after in vitro serial passage
Authors: Luiza H Galarion, Justin E Clarke, Harry Schofield, Alex J O'Neill
Journal: J Antimicrob Chemother
PubMed ID: 36416794
Doi: 10.1093/jac/dkac397
Products & Services: Custom RNAi Services   
High-Throughput and Efficient Intracellular Delivery Method via a Vibration-Assisted Nanoneedle/Microfluidic Composite System
Authors: Xuan Li , Yuan Ma , Yu Xue , Xuanhe Zhang , Linwen Lv , Qianghua Quan , Yiqing Chen , Guoxu Yu , Zhenwei Liang , Xinping Zhang , Ding Weng , Lei Chen , Kui Chen , Xin Han , Jiadao Wang
Journal: ACS Nano
PubMed ID: 36479877
Doi: 10.1021/acsnano.2c07852
Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1
Authors: Qi-Shan Wang , Kai-Jian Fan, Hui Teng , Sijia Chen , Bing-Xin Xu, Di Chen, Ting-Yu Wang
Journal: Elife
Doi: doi.org/10.7554/eLife.78085
Intranasal bovine β-defensin-5 enhances antituberculosis immunity in a mouse model by a novel protein-based respiratory mucosal vaccine
Authors: Zhengmin Liang, Hao Li, Mengjin Qu, Yiduo Liu, Yuanzhi Wang, Haoran Wang, Yuhui Dong, Yulan Chen, Xin Ge, Xiangmei Zhou
Journal: Virulence
PubMed ID: 35603910
Doi: 10.1080/21505594.2022.2080342
Products & Services: Endotoxin Detection & Removal System   
Molybdopterin biosynthesis pathway contributes to the regulation of SaeRS two-component system by ClpP in
Authors: Na Zhao, Yanan Wang, Junlan Liu, Ziyu Yang, Ying Jian, Hua Wang, Mahmoud Ahmed, Min Li, Taeok Bae, Qian Liu
Journal: Virulence
PubMed ID: 35481455
Doi: 10.1080/21505594.2022.2065961
Products & Services: Plasmid DNA Preparation   
Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants
Authors: Qihong Yan, Ruitian Hou, Xiaohan Huang, Yanjun Zhang, Ping He, Yudi Zhang, Banghui Liu, Qian Wang, Haiyue Rao, Xianying Chen, Xinwei Zhao, Xuefeng Niu, Jincun Zhao, Xiaoli Xiong, Ling Chen
Journal: Emerg Microbes Infect
PubMed ID: 36288106
Doi: 10.1080/22221751.2022.2140611
Unamplified and Real-Time Label-Free miRNA-21 Detection Using Solution-Gated Graphene Transistors in Prostate Cancer Diagnosis
Authors: Minghua Deng, Zhanpeng Ren, Huibin Zhang, Ziqin Li, Chenglong Xue, Jianying Wang, Dan Zhang, Huan Yang, Xianbao Wang, Jinhua Li
Journal: Adv Sci (Weinh)
PubMed ID: 36480308
Doi: 10.1002/advs.202205886
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes
Authors: Jakub Benýšek, Michal Buša, Petra Rubešová, Jindřich Fanfrlík, Martin Lepšík, Jiří Brynda, Zuzana Matoušková, Ulrike Bartz, Martin Horn, Michael Gütschow, Michael Mareš
Journal: J Enzyme Inhib Med Chem
PubMed ID: 35144520
Doi: 10.1080/14756366.2021.2024527
Products & Services: Plasmid DNA Preparation   
A De Novo Missense Variant in TUBG2 in a Child with Global Developmental Delay, Microcephaly, Refractory Epilepsy and Perisylvian Polymicrogyria
Authors: Salini Thulasirajah, Xueqi Wang, Erick Sell, Jorge Dávila, David A Dyment, Kristin D Kernohan
Journal: Genes
PubMed ID: 36672848
Doi: 10.3390/genes14010108
Products & Services: Mutagenesis Services   
Inhibition of autophagy reduces the rate of fluoride-induced LS8 apoptosis via regulating ATG5 and ATG7
Authors: Lin Zhao, Han Wang, Sijia Liu, Tao Xi, Liyuan Wang, Yang Li, Lu Chen, Ruan Jianping, Kristina Xiao Liang
Journal: J Biochem Mol Toxicol
PubMed ID: 36536498
Doi: 10.1002/jbt.23280
Products & Services: Gene Synthesis   
Cryo-EM Structure of the Type IV Pilus Extension ATPase from Enteropathogenic Escherichia coli
Authors: Ashok R Nayak , Pradip K Singh , Jinlei Zhao , Montserrat Samsó , Michael S Donnenberg
Journal: mBio
PubMed ID: 36326250
Doi: 10.1128/mbio.02270-22
Products & Services: Molecular Biology Reagents   
Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis
Authors: Li Ma, Junfeng Wei, Yanli Zeng, Junping Liu, Erhui Xiao, Yuehua Kang, Yi Kang
Journal: Drug Deliv
PubMed ID: 35099348
Doi: 10.1080/10717544.2022.2030428
Suchilactone inhibits the growth of acute myeloid leukaemia by inactivating SHP2
Authors: Jingjing Wu, Yuan Deng, Xin Zhang, Jingjing Ma, Xinqi Zheng, Yue Chen
Journal: Pharm Biol
PubMed ID: 34962431
Doi: 10.1080/13880209.2021.2017467
Products & Services: Custom DNA/RNA Oligos   
ADAR1 improved Treg cell function through the miR-21b/Foxp3 axis and inhibits the progression of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Authors: Yanru Zhao, Xiaoyan Zheng, Miaojing Li, Jing Zhao, Xiaoning Wang, Huachao Zhu
Journal: Int Immunopharmacol
PubMed ID: 36577155
Doi: 10.1016/j.intimp.2022.109620
Products & Services: Gene Synthesis   
GmYSL7 controls iron uptake, allocation, and cellular response of nodules in soybean
Authors: Xinying Wu, Yongliang Wang, Qiaohan Ni, Haizhen Li, Xuesong Wu, Zhanxin Yuan, Renhao Xiao, Ziyin Ren, Jingjing Lu, Jinxia Yun, Zhijuan Wang, Xia Li
Journal: J Integr Plant Biol
PubMed ID: 36107150
Doi: 10.1111/jipb.13364
DeGlyPHER: Highly sensitive site-specific analysis of N-linked glycans on proteins
Authors: Sabyasachi Baboo, Jolene K Diedrich, Salvador Martínez-Bartolomé, Xiaoning Wang, Torben Schiffner, Bettina Groschel, William R Schief, James C Paulson, John R Yates
Journal: Methods Enzymol
PubMed ID: 36948700
Doi: 10.1016/bs.mie.2022.09.004
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
Authors: Yunlong Cao, Fanchong Jian, Jing Wang, Yuanling Yu, Weiliang Song, Ayijiang Yisimayi, Jing Wang, Ran An, Xiaosu Chen, Na Zhang, Yao Wang, Peng Wang, Lijuan Zhao, Haiyan Sun, Lingling Yu, Sijie Yang, Xiao Niu, Tianhe Xiao, Qingqing Gu, Fei Shao, Xiaohua Hao, Yanli Xu, Ronghua Jin, Zhongyang Shen, Youchun Wang, Xiaoliang Sunney Xie
Journal: Nature
PubMed ID: 36535326
Doi: 10.1038/s41586-022-05644-7
Efficient Production of Epoxy-Norbornane from Norbornene by an Engineered P450 Peroxygenase
Authors: Yu Yan, Chenni Zheng, Wei Song, Jing Wu, Liang Guo, Cong Gao, Jia Liu, Xiulai Chen, Meng Zhu, Liming Liu
Journal: Chembiochem
PubMed ID: 36354378
Doi: 10.1002/cbic.202200529
Products & Services: Codon Optimization   
Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA1 and BA2
Authors: Bingjie Hu, Jasper Fuk-Woo Chan, Huan Liu, Yuanchen Liu, Yue Chai, Jialu Shi, Huiping Shuai, Yuxin Hou, Xiner Huang, Terrence Tsz-Tai Yuen, Chaemin Yoon, Tianrenzheng Zhu, Jinjin Zhang, Wenjun Li, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Bao-Zhong Zhang, Kwok-Yung Yuen, Hin Chu
Journal: Emerg Microbes Infect
PubMed ID: 36039901
Doi: 10.1080/22221751.2022.2117098
Products & Services: Plasmid DNA Preparation   
SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing
Authors: Fei He , Qi Yu , Min Wang , Rongsha Wang , Xuanyunjing Gong , Feng Ge , Xilan Yu , Shanshan Li
Journal: Nat Commun
PubMed ID: 36473858
Doi: 10.1038/s41467-022-35182-9
Reduced sensitivity of the SARS-CoV-2 Lambda variant to monoclonal antibodies and neutralizing antibodies induced by infection and vaccination
Authors: Meiyu Wang, Li Zhang, Qianqian Li, Bo Wang, Ziteng Liang, Yeqing Sun, Jianhui Nie, Jiajing Wu, Xiaodong Su, Xiaowang Qu, Yuhua Li, Youchun Wang, Weijin Huang
Journal: Emerg Microbes Infect
PubMed ID: 34818119
Doi: 10.1080/22221751.2021.2008775
Products & Services: Peptide Synthesis   
The direct binding of AMA1 to erythrocytes defines a RON2-independent invasion pathway
Authors: Seong-Kyun Lee, Leanne M Low, John F Andersen, Lee M Yeoh, Paola Carolina Valenzuela Leon, Damien R Drew, Johannes S P Doehl, Eric Calvo, Louis H Miller, James G Beeson, Karthigayan Gunalan
Journal: Proc Natl Acad Sci U S A
PubMed ID: 36577076
Doi: 10.1073/pnas.2215003120
Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions
Authors: Da Zou, Zeming Wu, Xin Yi, Yue Hui, Guangze Yang, Yun Liu, Haofei Wang, Anastasia Brooks, Haolu Wang, Xin Liu, Zhi Ping Xu, Michael S Roberts, Huajian Gao, Chun-Xia Zhao
Journal: Proc Natl Acad Sci U S A
PubMed ID: 36574680
Doi: 10.1073/pnas.2214757120
Products & Services: Peptide Synthesis   
Evaluation of immunological responses to third COVID-19 vaccine among people treated with sphingosine receptor-1 modulators and anti-CD20 therapy
Authors: Ilana Katz Sand, Sacha Gnjatic, Florian Krammer, Kevin Tuballes, Juan Manuel Carreño, Sammita Satyanarayan, Susan Filomena, Erin Staker, Johnstone Tcheou, Aaron Miller, Michelle Fabian, Neha Safi, Jamie Nichols, Jasmin Patel, Stephen Krieger, Stephanie Tankou, Sam Horng, Sylvia Klineova, Erin Beck, Miriam Merad, Fred Lublin
Journal: Mult Scler Relat Disord
PubMed ID: 36628884
Doi: 10.1016/j.msard.2022.104486
Products & Services: Molecular Biology Reagents   
Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss
Authors: Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brown
Journal: Glia
PubMed ID: 36480007
Doi: 10.1002/glia.24318
Products & Services: Stable Cell Lines   
Structure-function analysis of Cdc25 degradation at the maternal-to-zygotic transition
Authors: Patrick L Ferree, Maggie Xing, Jenny Q Zhang, Stefano Di Talia
Journal: Fly (Austin)
PubMed ID: 35227166
Doi: 10.1080/19336934.2022.2043095
Products & Services: GenParts™ DNA Fragments   
Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics
Authors: Changrong Shi , Qianyu Zhang , Yuying Yao , Fantian Zeng , Chao Du , Sureya Nijiati , Xuejun Wen , Xinyi Zhang , Hongzhang Yang , Haoting Chen , Zhide Guo , Xianzhong Zhang , Jinhao Gao , Weisheng Guo , Xiaoyuan Chen , Zijian Zhou
Journal: Nat Nanotechnol
PubMed ID: 36536041
Doi: 10.1038/s41565-022-01261-7
Products & Services: Recombinant Proteins   
Immune suppression of vaccine-induced CD8 T-cell responses by gamma retrovirus envelope is mediated by interleukin-10-producing CD4 T cells
Authors: Philip Podschwadt, Anna Malyshkina, Sonja Windmann, Athanasios Papadamakis, Leonie Kerkmann, Dennis Lapuente, Matthias Tenbusch, Mengji Lu, Michael Schindler, Karl Sebastian Lang, Wiebke Hansen, Wibke Bayer
Journal: Front Immunol
PubMed ID: 36605206
Doi: 10.3389/fimmu.2022.934399
Products & Services: Molecular Biology Reagents   
A novel method for silkworm cocoons self-degumming and its effect on silk fibers
Authors: Riyuan Wang, Yuancheng Wang, Jianxin Song, Chi Tian, Xinyuan Jing, Ping Zhao, Qingyou Xia
Journal: J Adv Res
PubMed ID: 36572337
Doi: 10.1016/j.jare.2022.12.005
Products & Services: Molecular Biology Reagents   
Upconversion nanoparticle-based optogenetic nanosystem for photodynamic therapy and cascade gene therapy
Authors: Xinyue Song, Fengyan Li, Feng Tian, Linlin Ren, Qi Wang, Chengfang Jiang, Tao Yan, Shusheng Zhang
Journal: Acta Biomater
PubMed ID: 36494007
Doi: 10.1016/j.actbio.2022.12.002
Products & Services: Gene Synthesis   
Potential of a novel flagellin epitope as a broad-spectrum vaccine candidate against enteric fever
Authors: Shania Vij, Reena Thakur, Laxmi Kumari, Chander Raman Suri, Praveen Rishi
Journal: Microb Pathog
PubMed ID: 36494021
Doi: 10.1016/j.micpath.2022.105936
Products & Services: Peptide Synthesis   
Proteolytic activation of human-specific Olduvai domains by the furin protease
Authors: Ashley Pacheco, Aaron Issaian, Jonathan Davis, Nathan Anderson, Travis Nemkov, Natasia Paukovich, Morkos A Henen, Beat Vögeli, James M Sikela, Kirk Hansen
Journal: Int J Biol Macromol
PubMed ID: 36581038
Doi: 10.1016/j.ijbiomac.2022.12.260

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