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Freshwater connectivity transforms spatially integrated signals of biodiversity

Authors: Joanne E Littlefair, José S Hleap, Vince Palace, Michael D Rennie, Michael J Paterson, Melania E Cristescu

Journal: Proc Biol Sci

PubMed ID: 37700653

Doi: 10.1098/rspb.2023.0841

Products & Services: Molecular Biology Reagents

Detection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins

Authors: Christopher M Bartley, Thomas T Ngo, Le Duy Do, Anastasia Zekeridou, Ravi Dandekar, Sergio Muñiz-Castrillo, Bonny D Alvarenga, Kelsey C Zorn, Asritha Tubati, Anne-Laurie Pinto, Weston D Browne, Patrick W Hullett, Mark Terrelonge, Ryan D Schubert, Amanda L Piquet, Binxia Yang, Mayra Montalvo, Andrew F Kung, Sabrina A Mann, Maulik P Shah, Michael D Geschwind, Jeffrey M Gelfand, Joseph L DeRisi, Sean J Pittock, Jérôme Honnorat, Samuel J Pleasure, Michael R Wilson

Journal: Ann Neurol

PubMed ID: 37632288

Doi: 10.1002/ana.26776

Products & Services: Recombinant Proteins

Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates

Authors: Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur Zalevsky, Andrej Sali, Colin M Brand, John A Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini

Journal: Res Sq

PubMed ID: 37790518

Doi: 10.21203/rs.3.rs-3263845/v1

Products & Services: PCR Cloning and Subcloning

C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer

Authors: Hui Wang, Yingkuan Liang, Te Zhang, Xinnian Yu, Xuming Song, Yuzhong Chen, Qixing Mao, Wenjie Xia, Bing Chen, Lin Xu, Gaochao Dong, Feng Jiang

Journal: Cell Death Differ

PubMed ID: 37689814

Doi: 10.1038/s41418-023-01222-0

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Soluble CD4 and low molecular weight CD4-mimetic compounds sensitize cells to be killed by anti-HIV cytotoxic immunoconjugates

Authors: Seth H Pincus, Megan Stackhouse, Connie Watt, Kelli Ober, Frances M Cole, Hung-Ching Chen, Amos B Smith Iii, Tami Peters

Journal: J Virol

PubMed ID: 37772823

Doi: 10.1128/jvi.01154-23

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Enterococcus faecium C171: Modulating the Immune Response to Acute Lethal Viral Challenge

Authors: Jielan Mi, Tana He, Xinyun Hu, Zhihao Wang, Tingting Wang, Xiaole Qi, Kai Li, Li Gao, Changjun Liu, Yanping Zhang, Suyan Wang, Yu Qiu, Zengqi Liu, Jie Song, Xiaomei Wang, Yulong Gao, Hongyu Cui

Journal: Int J Antimicrob Agents

PubMed ID: 37758064

Doi: 10.1016/j.ijantimicag.2023.106969

Products & Services: Protein and Antibody Isolation

TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in tachyzoites and bradyzoites

Authors: Robert D Murphy, Cortni A Troublefield, Joy S Miracle, Lyndsay E A Young, Corey O Brizzee, Animesh Dhara, Ramon C Sun, Craig W Vander Kooi, Matthew S Gentry, Anthony P Sinai

Journal: biorxiv

PubMed ID: 37808860

Doi: 10.1101/2023.09.29.560185

Products & Services: Protein and Antibody Isolation

Optimizing effector functions of monoclonal antibodies via tailored N-glycan engineering using a dual landing pad CHO targeted integration platform

Authors: Ngan T B Nguyen, Hau Wan Leung, Kuin Tian Pang, Shi Jie Tay, Ian Walsh, Andre B H Choo, Yuansheng Yang

Journal: Sci Rep

PubMed ID: 37731040

Doi: 10.1038/s41598-023-42925-1

Products & Services: Protein and Antibody Isolation

Loss of function of FIGNL1, a DNA damage response gene, causes human ovarian dysgenesis

Authors: Natan Florsheim, Larisa Naugolni, Fouad Zahdeh, Orit Lobel, Batel Terespolsky, Rachel Michaelson-Cohen, Merav Y Gold, Michal Goldberg, Paul Renbaum, Ephrat Levy-Lahad, David Zangen

Journal: Eur J Endocrinol

PubMed ID: 37740949

Doi: 10.1093/ejendo/lvad127

Products & Services: Protein and Antibody Isolation

Is the co-option of jasmonate signalling for botanical carnivory universal trait for all carnivorous plants?

Authors: Andrej Pavlovič, Jana Koller, Ondřej Vrobel, Ivo Chamrád, René Lenobel, Peter Tarkowski

Journal: J Exp Bot

PubMed ID: 37708289

Doi: 10.1093/jxb/erad359

Products & Services: Protein and Antibody Isolation

Acute and Long-Term Consequences of Co-opted doublesex on the Development of Mimetic Butterfly Color Patterns

Authors: Nicholas W VanKuren, Meredith M Doellman, Sofia I Sheikh, Daniela H Palmer Droguett, Darli Massardo, Marcus R Kronforst

Journal: Mol Biol Evol

PubMed ID: 37668300

Doi: 10.1093/molbev/msad196

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Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4

Authors: Thuy P Dao, Anitha Rajendran, Sarasi K K Galagedera, William Haws, Carlos A Castañeda

Journal: biorxiv

PubMed ID: 37808720

Doi: 10.1101/2023.09.27.559790

Products & Services: Protein and Antibody Isolation

Discovery and pharmacophoric characterization of chemokine network inhibitors using phage-display, saturation mutagenesis and computational modelling

Authors: Serena Vales, Jhanna Kryukova, Soumyanetra Chandra, Gintare Smagurauskaite, Megan Payne, Charlie J Clark, Katrin Hafner, Philomena Mburu, Stepan Denisov, Graham Davies, Carlos Outeiral, Charlotte M Deane, Garrett M Morris, Shoumo Bhattacharya

Journal: Nat Commun

PubMed ID: 37717048

Doi: 10.1038/s41467-023-41488-z

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Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors

Authors: Matteo Righi, Isaac Gannon, Matthew Robson, Saket Srivastava, Evangelia Kokalaki, Thomas Grothier, Francesco Nannini, Christopher Allen, Yuchen V Bai, James Sillibourne, Shaun Cordoba, Simon Thomas, Martin Pule

Journal: Cancer Immunol Res

PubMed ID: 37352396

Doi: 10.1158/2326-6066.CIR-22-0640

Products & Services: Protein and Antibody Isolation

Discovery and identification of a novel canine coronavirus causing a diarrhea outbreak in Vulpes

Authors: Yuting Liu, Yao Deng, Sheng Niu, Na Zhu, Jingdong Song, Xiaoshuang Zhang, Weiting Su, Wenhui Nie, Roujian Lu, David M Irwin, George Fu Gao, Wenling Wang, Qihui Wang, Wenjie Tan, Shuyi Zhang

Journal: Sci Bull (Beijing)

PubMed ID: 37758615

Doi: 10.1016/j.scib.2023.09.011

Products & Services: Molecular Biology Reagents

The Dictyostelium discoideum FimA protein, unlike yeast and plant fimbrins, is regulated by calcium similar to mammalian plastins

Authors: Hiroaki Ishida, Andrew G Woodman, Naoya Kitada, Tomoyasu Aizawa, Hans J Vogel

Journal: Sci Rep

PubMed ID: 37758724

Doi: 10.1038/s41598-023-42682-1

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Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors

Authors: Nicholas D Clark, Christopher Pham, Kurni Kurniyati, Ching Wooen Sze, Laurynn Coleman, Qin Fu, Sheng Zhang, Michael G Malkowski, Chunhao Li

Journal: PLoS Pathog

PubMed ID: 37747935

Doi: 10.1371/journal.ppat.1011674

Products & Services: Molecular Biology Reagents

An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses

Authors: Feifei Xiong, Chi Zhang, Baoyuan Shang, Mei Zheng, Qi Wang, Yahong Ding, Jian Luo, Xiuling Li

Journal: Emerg Microbes Infect

PubMed ID: 37671994

Doi: 10.1080/22221751.2023.2256422

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A digital twin for DNA data storage based on comprehensive quantification of errors and biases

Authors: Andreas L Gimpel, Wendelin J Stark, Reinhard Heckel, Robert N Grass

Journal: Nat Commun

PubMed ID: 37758710

Doi: 10.1038/s41467-023-41729-1

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Adipose‑derived stem cell‑mediated alphastatin targeting delivery system inhibits angiogenesis and tumor growth in glioma

Authors: Chen Liang, Ting Wei, Ting Zhang, Chen Niu

Journal: Mol Med Rep

PubMed ID: 37772382

Doi: 10.3892/mmr.2023.13102

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Ultrasound-Induced Microbubble Cavitation for Targeted Delivery of MiR-29b Mimic to Treat Cardiac Fibrosis

Authors: Rafey A Feroze, Jonathan Kopechek, Jianhui Zhu, Xucai Chen, Flordeliza S Villanueva

Journal: Ultrasound Med Biol

PubMed ID: 37749011

Doi: 10.1016/j.ultrasmedbio.2023.08.025

Products & Services: Protein and Antibody Isolation

LncRNA LINC01123 promotes malignancy of ovarian cancer by targeting hsa-miR-516b-5p/VEGFA

Authors: Bing Dong, Cuiping Li, Xiaomeng Xu, Yan Wang, Yuewen Li, Xingmei Li

Journal: Genes Genomics

PubMed ID: 37728844

Doi: 10.1007/s13258-023-01440-3

Products & Services: Gene Synthesis

ATP induces folding of ALS-causing C71G-hPFN1 and nascent hSOD1

Authors: Jian Kang, Liangzhong Lim, Jianxing Song

Journal: Commun Chem

PubMed ID: 37670116

Doi: 10.1038/s42004-023-00997-0

Products & Services: Gene Synthesis

Glycoengineering directs de novo biomanufacturing of UPEC O21 O-antigen polysaccharide based glycoprotein

Authors: Yuhui Wang , Andrei V Perepelov , Sof'ya N Senchenkova , Gege Lu , Xiaohan Wang , Guozhen Ma , Qian Yang , Jian Yuan , Yanling Wang , Lijie Xie , Xiaolong Jiang , Jingliang Qin , Dan Liu , Miaomiao Liu , Di Huang , Bin Liu

Journal: Int J Biol Macromol .

PubMed ID: 37739281

Doi: 10.1016/j.ijbiomac.2023.126993

Products & Services: Protein Electrophoresis and Western

Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR

Authors: Emily Maria Ploeg , Douwe Freerk Samplonius, Xiao Xiong , Xiurong Ke, Mark Alexander Johannes Martinus Hendriks , Isabel Britsch , Anne Paulien van Wijngaarden , Hao Zhang , Wijnand Helfrich

Journal: J Immunother Cancer .

PubMed ID: 37734877

Doi: 10.1136/jitc-2023-006837

Products & Services: Gene Synthesis

Antibacterial Fusobacterium nucleatum-Mimicking Nanomedicine to Selectively Eliminate Tumor-Colonized Bacteria and Enhance Immunotherapy Against Colorectal Cancer

Authors: Linfu Chen , Rui Zhao , Jingjing Shen , Nanhui Liu , Zixuan Zheng , Yu Miao , Jiafei Zhu , Lin Zhang , Yingyao Wang , Huapan Fang , Jun Zhou , Maoyi Li , Yang Yang , Zhuang Liu , Qian Chen

Journal: Adv Mater .

PubMed ID: 37722134

Doi: 10.1002/adma.202306281

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Photoactivated DNA Nanodrugs Damage Mitochondria to Improve Gene Therapy for Reversing Chemoresistance

Authors: Danyu Wang , Hua Yi , Shizhen Geng , Chuanmei Jiang , Jingwen Liu , Jie Duan , Zhenzhong Zhang, Jinjin Shi , Haiwei Song , Zhenzhen Guo, Kaixiang Zhang

Journal: ACS Nano .

PubMed ID: 37606317

Doi: 10.1021/acsnano.3c04002

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RIG-I promotes immune evasion of colon cancer by modulating PD-L1 ubiquitination

Authors: Yangyang Zhang # 1, Lingxiu Zeng # 1, Meng Wang 1, Zhenwei Yang 1, Hailin Z 1, Liping Gao , Ranran Zhang , Jialong Liu , Wenqing Shan , Ying Chang ,Lan Liu , Qiu Zhao , Yong Li , Jing Liu

Journal: J Immunother Cancer .

PubMed ID: 37758653

Doi: 10.1136/jitc-2023-007313

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Validation of flavivirus infectious clones carrying fluorescent markers for antiviral drug screening and replication studies

Authors: Liubov Cherkashchenko , Nathalie Gros, Alice Trausch, Aymeric Neyret, Mathilde Hénaut, Gregor Dubois, Matthieu Villeneuve, Christine Chable-Bessia, Sébastien Lyonnais, Andres Merits, Delphine Muriaux

Journal: Front Microbiol

PubMed ID: 37779700

Doi: 10.3389/fmicb.2023.1201640

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Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A

Authors: Zhiheng Deng, Huasong Ai, Maoshen Sun, Zebin Tong, Yunxiang Du, Qian Qu, Liying Zhang, Ziyu Xu, Shixian Tao, Qiang Shi, Jia-Bin Li, Man Pan, Lei Liu

Journal: Mol Cell

PubMed ID: 37633270

Doi: 10.1016/j.molcel.2023.08.001

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Nucleic Acid Mediated Activation of a Short Prokaryotic Argonaute Immune System

Authors: Jithesh Kottur, Radhika Malik, Aneel K Aggarwal

Journal: biorxiv

PubMed ID: 37745538

Doi: 10.1101/2023.09.17.558117

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Refactoring the architecture of a polyketide gene cluster enhances docosahexaenoic acid production in Yarrowia lipolytica through improved expression and genetic stability

Authors: Demian Dietrich, Sofija Jovanovic-Gasovic, Peng Cao, Michael Kohlstedt, Christoph Wittmann

Journal: Microb Cell Fact

PubMed ID: 37773137

Doi: 10.1186/s12934-023-02209-9

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Cryo-EM structures of human organic anion transporting polypeptide OATP1B1

Authors: Ziyang Shan, Xuemei Yang, Huihui Liu, Yafei Yuan, Yuan Xiao, Jing Nan, Wei Zhang, Wenqi Song, Jufang Wang, Feiwen Wei, Yanqing Zhang

Journal: Cell Res

PubMed ID: 37674011

Doi: 10.1038/s41422-023-00870-8

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Immature leaves are the dominant volatile-sensing organs of maize

Authors: Lei Wang, Simon Jäggi, Tristan M Cofer, Jamie M Waterman, Mario Walthert, Gaétan Glauser, Matthias Erb

Journal: Current Biology

PubMed ID: 37597519

Doi: 10.1016/j.cub.2023.07.045

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DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress

Authors: Xu Lin, Ye-Han Liu, Huan-Qi Zhang, Lin-Wen Wu, Qi Li, Jun Deng, Qingyi Zhang, Yuhong Yang, Chong Zhang, Yang-Ling Li, Jian Hu

Journal: Cancer Cell Int

PubMed ID: 37742009

Doi: 10.1186/s12935-023-03047-w

Products & Services: Protein and Antibody Isolation

Phosphatidylinositol-specific phospholipase C can decrease Müller cell viability and suppress its phagocytic activity by modulating PI3K/AKT signaling pathway

Authors: Bianjin Sun, Shudan Lin, Mengmeng Zheng, Beijia Zheng, Liping Mao, Yunfeng Gu, Jiabei Cai, Yiran Dai, Meiqin Zheng, Yongliang Lou

Journal: Can J Microbiol

PubMed ID: 37672795

Doi: 10.1139/cjm-2023-0044

Products & Services: Protein and Antibody Isolation

Genome characterization of the novel lytic phage vB_AbaAut_ChT04 and the antimicrobial activity of its lysin peptide against Acinetobacter baumannii isolates from different time periods

Authors: Udomluk Leungtongkam, Thawatchai Kitti, Supat Khongfak, Rapee Thummeepak, Kannipa Tasanapak, Jintana Wongwigkarn, Sophit Khanthawong, Aouatif Belkhiri, Henrique G Ribeiro, John S Turner, Danish J Malik, Sutthirat Sitthisak

Journal: Arch Virol

PubMed ID: 37660314

Doi: 10.1007/s00705-023-05862-y

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Omicron variant neutralizing antibodies following BNT162b2 BA4/5 versus mRNA-1273 BA1 bivalent vaccination in patients with end-stage kidney disease

Authors: Kevin Yau, Alexandra Kurtesi, Freda Qi, Melanie Delgado-Brand, Tulunay R Tursun, Queenie Hu, Miten Dhruve, Christopher Kandel, Omosomi Enilama, Adeera Levin, Yidi Jiang, W Rod Hardy, Darren A Yuen, Jeffrey Perl, Christopher T Chan, Jerome A Leis, Matthew J Oliver, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich

Journal: Nat Commun

PubMed ID: 37758707

Doi: 10.1038/s41467-023-41678-9

Products & Services: Protein and Antibody Isolation

Discovery of ACE Inhibitory Peptides Derived from Green Coffee Using In Silico and In Vitro Methods

Authors: Haopeng Dai, Min He, Guilin Hu, Zhongrong Li, Abdulbaset Al-Romaima, Zhouwei Wu, Xiaocui Liu, Minghua Qiu

Journal: Foods

PubMed ID: 37761189

Doi: 10.3390/foods12183480

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Innate receptors with high specificity for HLA class I-peptide complexes

Authors: Malcolm J W Sim, Paul Brennan, Katherine L Wahl, Jinghua Lu, Sumati Rajagopalan, Peter D Sun, Eric O Long

Journal: Sci Immunol

PubMed ID: 37683038

Doi: 10.1126/sciimmunol.adh1781

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AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells

Authors: R Leo Sakemura, Mehrdad Hefazi, Michelle J Cox, Elizabeth L Siegler, Sutapa Sinha, Michael J Hansen, Carli M Stewart, Jennifer M Feigin, Claudia Manriquez Roman, Kendall J Schick, Ismail Can, Erin E Tapper, Paulina Horvei, Mohamad M Adada, Evandro D Bezerra, Lionel Aurelien Kankeu Fonkoua, Michael W Ruff, Cynthia L Forsman, Wendy K Nevala, Justin C Boysen, Renee C Tschumper, Cory L Grand, Kameswara R Kuchimanchi, Lars Mouritsen, Jason M Foulks, Steven L Warner, Timothy G Call, Sameer A Parikh, Wei Ding, Neil E Kay, Saad S Kenderian

Journal: Cancer Immunol Res

PubMed ID: 37378662

Doi: 10.1158/2326-6066.CIR-22-0254

Products & Services: Protein and Antibody Isolation

A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization

Authors: Hannah E Gering , Xiaojun Li , Haoyu Tang , Paul D Swartz , Wei-Chen Chang , Thomas M Makris

Journal: J Am Chem Soc .

PubMed ID: 37611404

Doi: 10.1021/jacs.3c04542

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A CRISPRCas12a-SERS platform for amplification-free detection of African swine fever virus genes

Authors: Huimin Wang , Ailing Su , Chengxin Bao , Chongyang Liang , Weiqing Xu , Jingjing Chang , Shuping Xu

Journal: Talanta .

PubMed ID: 37741267

Doi: 10.1016/j.talanta.2023.125225

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Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope

Authors: Ding Zhao , Xun Gao , Jiale Zhou , Jinze Li , Yuqiang Qian , Di Wang , Wenchao Niu , Tao Zhang , Mingyang Hu , Haoyang Xiong , Liangxue Lai , Zhanjun Li

Journal: BMC Biol .

PubMed ID: 37946200

Doi: 10.1186/s12915-023-01754-4

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Metasurface-Driven and Nanomaterial-Coupled Plasmonic Biosensor for the Rapid and Quantitative Clinical Identification of Neutralizing Antibodies against SARS-CoV-2 Variants

Authors: Rui Li, Ya Zhao, Hongli Fan, Hanlin Zhou, Shaoping Yin, Qiang Zhang, Meilin Jin,Gang L. Liu,and Liping Huang

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202306145

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A real-time analysis of protein transport via the twin arginine translocation pathway in response to different components of the protonmotive force

Authors: Wenjie Zhou, Binhan Hao, Terry M Bricker, Steven M Theg

Journal: J Biol Chem

PubMed ID: 37742925

Doi: 10.1016/j.jbc.2023.105286

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Nuclear factor E2-associated factor 2 and musculoaponeurotic fibrosarcoma K mediate regulation glutathione peroxidase of Cristaria plicata after microcystin-induced oxidative stress

Authors: Xinying Cao, Jinhua An, Shanshan Zhu, Maolin Feng, Yang Gang, Chungen Wen, Baoqing Hu

Journal: Comp Biochem Physiol C Toxicol Pharmacol

PubMed ID: 37689170

Doi: 10.1016/j.cbpc.2023.109742

Products & Services: Protein and Antibody Isolation

Survey of white-footed mice in Connecticut, USA reveals low SARS-CoV-2 seroprevalence and infection with divergent betacoronaviruses

Authors: Rebecca Earnest, Anne M Hahn, Nicole M Feriancek, Matthew Brandt, Renata B Filler, Zhe Zhao, Mallery I Breban, Chantal B F Vogels, Nicholas F G Chen, Robert T Koch, Abbey J Porzucek, Afeez Sodeinde, Alexa Garbiel, Claire Keanna, Hannah Litwak, Heidi R Stuber, Jamie L Cantoni, Virginia E Pitzer, Ximena A Olarte Castillo, Laura B Goodman, Craig B Wilen, Megan A Linske, Scott C Williams, Nathan D Grubaugh

Journal: biorxiv

PubMed ID: 37808797

Doi: 10.1101/2023.09.22.559030

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Electrostatics-Based Computational Design and Experimental Analysis of Buforin II Antimicrobial Peptide Variants with Increased DNA Affinities

Authors: Qiao Li, Gabriela Kim, Lisha Jing, Xiaoxuan Ji, Donald E Elmore, Mala L Radhakrishnan

Journal: ACS Omega

PubMed ID: 37744799

Doi: 10.1021/acsomega.3c04023

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Rapid, tunable, and multiplexed detection of RNA using convective array PCR

Authors: Andrew T Sullivan, Vibha Rao, Tyler Rockwood, Jahnavi Gandhi, Sarah Gruzka, Logan O'Connor, Bonnie Wang, Katherine B Ragan, David Yu Zhang, Dmitriy Khodakov

Journal: Commun Biol

PubMed ID: 37741867

Doi: 10.1038/s42003-023-05346-4

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