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NRXN1 depletion in the medial prefrontal cortex induces anxiety-like behaviors and abnormal social phenotypes along with impaired neurite outgrowth in rat

Authors: Di Wu, Jiansheng Zhu, Lianghui You, Jingyu Wang, Sufen Zhang, Zhonghui Liu, Qu Xu, Xiaojie Yuan, Lei Yang, Wei Wang, Meiling Tong, Qin Hong, Xia Chi

Journal: J Neurodev Disord

PubMed ID: 36737720

Doi: 10.1186/s11689-022-09471-9

Products & Services: Molecular Biology Reagents

Application of an electro elution system for direct purification of linear covalently closed DNA fragments

Authors: F Talebnia, D Pushparajah, S Chandrasekaran, S J Hersch, N Nafissi, R Slavcev

Journal: J Chromatogr B Analyt Technol Biomed Life Sci

PubMed ID: 36842293

Doi: 10.1016/j.jchromb.2023.123622

Products & Services: Molecular Biology Reagents

Whole genome sequencing of Malaysian colorectal cancer patients reveals specific druggable somatic mutations

Authors: Ryia Illani Mohd Yunos, Nurul-Syakima Ab Mutalib, Jia-Shiun Khoo, Sazuita Saidin, Muhiddin Ishak, Saiful Effendi Syafruddin, Francis Yew Fu Tieng, Najwa Farhah Md Yusof, Mohd Ridhwan Abd Razak, Norshahidah Mahamad Nadzir, Nadiah Abu, Isa Md Rose, Ismail Sagap, Luqman Mazlan, Rahman Jamal

Journal: Front Mol Biosci

PubMed ID: 36866106

Doi: 10.3389/fmolb.2022.997747

Products & Services: Stable Cell Lines

Fragment-Based Phasing of Peptidic Nanocrystals by MicroED

Authors: Logan S Richards, Maria D Flores, Claudia Millán, Calina Glynn, Chih-Te Zee, Michael R Sawaya, Marcus Gallagher-Jones, Rafael J Borges, Isabel Usón, Jose A Rodriguez

Journal: ACS Bio Med Chem Au

PubMed ID: 37096030

Doi: 10.1021/acsbiomedchemau.2c00082

Products & Services: Peptide Synthesis

DhFIG_2, a gene of nematode-trapping fungus Dactylellina haptotyla that encodes a component of the low-affinity calcium uptake system, is required for conidiation and knob-trap formation

Authors: Xiaozhou Zhao, Yani Fan, Weiwei Zhang, Meichun Xiang, Seogchan Kang, Shunxian Wang, Xingzhong Liu

Journal: Fungal Genet Biol

PubMed ID: 36849068

Doi: 10.1016/j.fgb.2023.103782

Products & Services: Gene Synthesis

A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma

Authors: Xianli Du, Jing Pang, Bin Gu, Tian Si, Yan Chang, Tianqi Li, Min Wu, Zicheng Wang, Yuxia Wang, Jiannan Feng, Ning Wu, Jianghong Man, Huiyan Li, Ailing Li, Tong Zhang, Bo Wang, Xiaotao Duan

Journal: Nucleic Acids Res

PubMed ID: 36660824

Doi: 10.1093/nar/gkad002

Products & Services: Proteins, Expression, Isolation and Analysis

Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp

Authors: Jie Gao, Ye-Jia Song, Hao Wang, Bao-Rui Zhao, Xian-Wei Wang

Journal: MBio

PubMed ID: 36779788

Doi: 10.1128/mbio.02919-22

Products & Services: Peptide Synthesis

N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

Authors: Hidehiko Okuma, Jeffrey M Hord, Ishita Chandel, David Venzke, Mary E Anderson, Ameya S Walimbe, Soumya Joseph, Zeita Gastel, Yuji Hara, Fumiaki Saito, Kiichiro Matsumura, Kevin P Campbell

Journal: Elife

PubMed ID: 36723429

Doi: 10.7554/eLife.82811

Products & Services: Combinatorial DNA Libraries

Planthopper salivary sheath protein LsSP1 contributes to manipulation of rice plant defenses

Authors: Hai-Jian Huang, Yi-Zhe Wang , Li-Li Li , Hai-Bin Lu, Jia-Bao Lu, Xin Wang , Zhuang-Xin Ye , Ze-Long Zhang, Yu-Juan He, Gang Lu , Ji-Chong Zhuo , Qian-Zhuo Mao , Zong-Tao Sun , Jian-Ping Chen, Jun-Min Li , Chuan-Xi Zhang

Journal: Nat Commun .

PubMed ID: 36759625

Doi: 10.1038/s41467-023-36403-5

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Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules

Authors: Yan-Hong Ma, Xu Hong, Fang Wu, Xin-Feng Xu, Rui Li, Jin Zhong, Yao-Qi Zhou, Shu-Wen Liu, Jian Zhan, Wei Xu

Journal: Acta Pharmacol Sin

PubMed ID: 36759643

Doi: 10.1038/s41401-023-01055-0

Products & Services: PCR Cloning and Subcloning

De novo assembled transcriptomics assisted label-free quantitative proteomics analysis reveals sex-specific proteins in the intestinal tissue of Haemaphysalis qinghaiensis

Authors: Hejia Ma, Eloiza May Galon, Yanjun Lao, Ming Kang, Xuenan Xuan, Jixu Li, Yali Sun

Journal: Infect Genet Evol

PubMed ID: 36773671

Doi: 10.1016/j.meegid.2023.105409

Products & Services: PCR Cloning and Subcloning

Transferrin Receptor Protein 1 Is an Entry Factor for Rabies Virus

Authors: Xinxin Wang, Zhiyuan Wen, Huizhen Cao, Jie Luo, Lei Shuai, Chong Wang, Jinying Ge, Xijun Wang, Zhigao Bu, Jinliang Wang

Journal: J Virol

PubMed ID: 36779762

Doi: 10.1128/jvi.01612-22

Products & Services: Proteins, Expression, Isolation and Analysis

Lipid-induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells

Authors: Eshani Karmakar, Nabanita Das, Bidisha Mukherjee, Prosenjit Das, Satinath Mukhopadhyay, Sib Sankar Roy

Journal: Biochem Cell Biol

PubMed ID: 36787544

Doi: 10.1139/bcb-2022-0266

Products & Services: PCR Cloning and Subcloning

BioID2 screening identifies KIAA1671 as an EPS8 proximal factor that marks sites of microvillus growth

Authors: Isabella M Gaeta, Matthew J Tyska

Journal: Mol Biol Cell

PubMed ID: 36790915

Doi: 10.1091/mbc.E22-11-0498

Products & Services: Gene Synthesis

Cas9-orthologue-mediated cytosine and adenine base editors recognizing NNAAAA PAM sequences

Authors: Min Li, Yuting Zhao, Xiaowen Xue, Jingli Zhong, Jianxiang Lin, Jiankui Zhou, Wenhua Yu, Jun Chen, Yunbo Qiao

Journal: Biotechnol J

PubMed ID: 36800529

Doi: 10.1002/biot.202200533

Products & Services: Proteins, Expression, Isolation and Analysis

Using a modified piggyBac transposon-combined Cre/loxP system to produce selectable reporter-free transgenic bovine mammary epithelial cells for somatic cell nuclear transfer

Authors: Guangdong Hu, Meijun Song, Yan Wang, Kexing Hao, Jing Wang, Yong Zhang

Journal: Genesis

PubMed ID: 36748563

Doi: 10.1002/dvg.23510

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant vesicular stomatitis virus-vectored vaccine induces long-lasting immunity against Nipah virus disease

Authors: Courtney Woolsey, Viktoriya Borisevich, Alyssa C Fears, Krystle N Agans, Daniel J Deer, Abhishek N Prasad, Rachel O'Toole, Stephanie L Foster, Natalie S Dobias, Joan B Geisbert, Karla A Fenton, Robert W Cross, Thomas W Geisbert

Journal: J Clin Invest

PubMed ID: 36445779

Doi: 10.1172/JCI164946

Products & Services: Peptide Synthesis

Reaction intensification for biocatalytic production of polyphenolic natural product di-C-β-glucosides

Authors: Tuo Li, Annika J E Borg, Leo Krammer, Rolf Breinbauer, Bernd Nidetzky

Journal: Biotechnol Bioeng

PubMed ID: 36787984

Doi: 10.1002/bit.28354

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Chimeric Hepatitis B core virus-like particles harboring SARS-CoV2 epitope elicit a humoral immune response in mice

Authors: Sima Sazegari, Malihe Akbarzadeh Niaki, Alireza Afsharifar, Ali Niazi, Abdollah Derakhshandeh, Maryam Moradi Vahdat, Farshad Hemmati, Mohammad Hadi Eskandari

Journal: Microb Cell Fact

PubMed ID: 36841778

Doi: 10.1186/s12934-023-02043-z

Products & Services: PCR Cloning and Subcloning

Evaluate the guide RNA effectiveness -mediated transient assays in

Authors: Zhibo Wang, Zachary Shea, Qi Li, Kunru Wang, Kerri Mills, Bo Zhang, Bingyu Zhao

Journal: Front Plant Sci

PubMed ID: 36890894

Doi: 10.3389/fpls.2023.1111683

Products & Services: Proteins, Expression, Isolation and Analysis

The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex

Authors: Zeyuan Guan, Juan Chen, Ruiwen Liu, Yanke Chen, Qiong Xing, Zhangmeng Du, Meng Cheng, Jianjian Hu, Wenhui Zhang, Wencong Mei, Beijing Wan, Qiang Wang, Jie Zhang, Peng Cheng, Huanyu Cai, Jianbo Cao, Delin Zhang, Junjie Yan, Ping Yin, Michael Hothorn, Zhu Liu

Journal: Nat Commun

PubMed ID: 36759618

Doi: 10.1038/s41467-023-36466-4

Products & Services: Peptide Synthesis

Chromium exposure altered metabolome and microbiome-associated with neurotoxicity in zebrafish

Authors: Tongtong Yan, Yawen Xu, Yuqi Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu

Journal: J Appl Toxicol

PubMed ID: 36727205

Doi: 10.1002/jat.4440

Products & Services: Gene Synthesis

Delivery of spike-RBD by bacterial type three secretion system for SARS-CoV-2 vaccine development

Authors: Yuchen Zhou, Jing Qu, Xiaomeng Sun, Zhuo Yue, Yingzi Liu, Keli Zhao, Fan Yang, Jie Feng, Xiaolei Pan, Yongxin Jin, Zhihui Cheng, Liang Yang, Un-Hwan Ha, Weihui Wu, Liang Li, Fang Bai

Journal: Front Immunol

PubMed ID: 36895557

Doi: 10.3389/fimmu.2023.1129705

Products & Services: Recombinant Proteins

The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread

Authors: A C Gomes, I A Baraniak, A Lankina, Z Moulder, P Holenya, C Atkinson, G Tang, T Mahungu, F Kern, P D Griffiths, M B Reeves

Journal: Nat Commun

PubMed ID: 36823200

Doi: 10.1038/s41467-023-36683-x

Products & Services: Gene Synthesis

Analysis of Bacterial Microcompartments and Shell Protein Superstructures by Confocal Microscopy

Authors: Daniel S Trettel, Wade C Winkler

Journal: Microbiol Spectr

PubMed ID: 36786617

Doi: 10.1128/spectrum.03357-22

Products & Services: Peptide Synthesis

Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening

Authors: Ling Deng, Li Yang, Shuhan Zhu, Man Li, Yu Wang, Xiaolong Cao, Qiongyao Wang, Linlang Guo

Journal: Cell Death Discov

PubMed ID: 36725843

Doi: 10.1038/s41420-023-01315-2

Products & Services: Molecular Biology Reagents

Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment

Authors: Robin M Hallett, Ester Bonfill-Teixidor, Raffaella Iurlaro, Alexandra Arias, Swetha Raman, Peter Bayliss, Olga Egorova, Almudena Neva-Alejo, Aj Robert McGray, Esther Lau, Alexandre Bosch, Melissa Beilschmidt, Dorothea Maetzel, Johan Fransson, Isabel Huber-Ruano, Judit Anido, Jean-Philippe Julien, Patricia Giblin, Joan Seoane

Journal: Clin Cancer Res

PubMed ID: 36441800

Doi: 10.1158/1078-0432.CCR-21-1888

Products & Services: Peptide Synthesis

Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells

Authors: Pratikshya Adhikari, Tolulope E Ayo, John C Vines, Shuzo Sugita, Hao Xu

Journal: Inflamm Res

PubMed ID: 36725743

Doi: 10.1007/s00011-023-01698-z

Products & Services: Proteins, Expression, Isolation and Analysis

Mechanism of inhibition of CRISPR-Cas9 by anti-CRISPR protein AcrIIC1

Authors: Yalan Zhu, Sen Yin, Zhao Li

Journal: Biochem Biophys Res Commun

PubMed ID: 36878037

Doi: 10.1016/j.bbrc.2023.02.065

Products & Services: Molecular Biology Reagents

Non-specific and specific DNA binding modes of bacterial histone, HU, separately regulate distinct physiological processes through different mechanisms

Authors: Subhash C Verma, Adam Harned, Kedar Narayan, Sankar Adhya

Journal: Mol Microbiol

PubMed ID: 36708073

Doi: 10.1111/mmi.15033

Products & Services: Proteins, Expression, Isolation and Analysis

Design of a Tumor Binding GMCSF as Intratumoral Immunotherapy of Solid Tumors

Authors: Aparna Raghavachar Chakravarti, Chad E Groer, Huan Gong, Vivian Yudistyra, Marcus Laird Forrest, Cory J Berkland

Journal: Mol Pharm

PubMed ID: 36825806

Doi: 10.1021/acs.molpharmaceut.2c00897

Products & Services: Gene Synthesis

Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants

Authors: Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang

Journal: Nat Commun

PubMed ID: 36828833

Doi: 10.1038/s41467-023-36761-0

Products & Services: Recombinant Antibody Expression

Expression, purification, and characterisation of the p53 binding domain of Retinoblastoma binding protein 6 (RBBP6)

Authors: Bonnie L Russell, Monde Ntwasa

Journal: PLoS ONE

PubMed ID: 36763571

Doi: 10.1371/journal.pone.0277478

Products & Services: Proteins, Expression, Isolation and Analysis

LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway

Authors: Sijia Han, Xueying Jin, Tianyu Hu, Feng Chi

Journal: Oncol Rep

PubMed ID: 36799186

Doi: 10.3892/or.2023.8497

Products & Services: Stable Cell Lines

pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

Authors: Shi-Hao Zhou,‡Ru-Yan Zhang,Zi-Wei You, Yong-Ke Zou, Yu Wen, Jian Wang, Dong Ding, Miao-Miao Bian, Zhi-Ming Zhang, Hong Yuan, Guang-Fu Yang, and Jun Guo

Journal: ACS Applied Materials & Interfaces

Doi: 10.1021/acsami.2c19736

Products & Services: Recombinant Proteins

Function of the bacteriophage P2 baseplate central spike Apex domain in the infection process

Authors: John-Mark Miller, Ekaterina S Knyazhanskaya, Sergii A Buth, Nikolai S Prokhorov, Petr G Leiman

Journal: biorxiv

PubMed ID: 36865152

Doi: 10.1101/2023.02.25.529910

Products & Services: Proteins, Expression, Isolation and Analysis

A novel binary pesticidal protein from Chryseobacterium arthrosphaerae controls western corn rootworm by a different mode of action to existing commercial pesticidal proteins

Authors: Rania Jabeur, Virginie Guyon, Szabolcs Toth, Adriano E Pereira, Man P Huynh, Zakia Selmani, Erin Boland, Mickael Bosio, Laurent Beuf, Pete Clark, David Vallenet, Wafa Achouak, Carine Audiffrin, François Torney, Wyatt Paul, Thierry Heulin, Bruce E Hibbard, Stefan Toepfer, Christophe Sallaud

Journal: PLoS ONE

PubMed ID: 36800363

Doi: 10.1371/journal.pone.0267220

Products & Services: Proteins, Expression, Isolation and Analysis

Mechanistic Basis for a Connection between the Catalytic Step and Slow Opening Dynamics of Adenylate Kinase

Authors: Beata Dulko-Smith, Pedro Ojeda-May, Jörgen Ådén, Magnus Wolf-Watz, Kwangho Nam

Journal: J Chem Inf Model

PubMed ID: 36802243

Doi: 10.1021/acs.jcim.2c01629

Products & Services: Proteins, Expression, Isolation and Analysis

Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

Authors: Raaj S Mehta, Jared R Mayers, Yancong Zhang, Amrisha Bhosle, Nathaniel R Glasser, Long H Nguyen, Wenjie Ma, Sena Bae, Tobyn Branck, Kijun Song, Luke Sebastian, Julian Avila Pacheco, Hyuk-Soo Seo, Clary Clish, Sirano Dhe-Paganon, Ashwin N Ananthakrishnan, Eric A Franzosa, Emily P Balskus, Andrew T Chan, Curtis Huttenhower

Journal: Nat Med

PubMed ID: 36823301

Doi: 10.1038/s41591-023-02217-7

Products & Services: Proteins, Expression, Isolation and Analysis

Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

Authors: Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao, Sheng Zhang, Fan Jiang, Renyi Kong, Xiao Yu, Xiaojian Cao, Lei Yang, Hongtao Chen

Journal: Cell Commun Signal

PubMed ID: 36797790

Doi: 10.1186/s12964-022-01036-6

Products & Services: Proteins, Expression, Isolation and Analysis

Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy

Authors: Natalia Plewa, Lucia Poncette, Thomas Blankenstein

Journal: J Immunother Cancer

PubMed ID: 36822673

Doi: 10.1136/jitc-2022-006001

Products & Services: Peptide Synthesis

The SpACE-CCM: A facile and versatile cell culture medium-based biosensor for detection of SARS-CoV-2 spike-ACE2 interaction

Authors: Youngwook Ham, Nam-Chul Cho, Daeyong Kim, Jung-Hee Kim, Min Ju Jo, Min Seon Jeong, Bo-Yeong Pak, Sanghyeok Lee, Mi-Kyung Lee, Seung-Wook Chi, Tae-Don Kim, Nak Cheol Jeong, Sungchan Cho

Journal: Biosens Bioelectron

PubMed ID: 36827795

Doi: 10.1016/j.bios.2023.115169

Products & Services: Molecular Biology Reagents

Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids

Authors: Victoria L Thai, Diego O Candelas, J Kent Leach

Journal: Ann Biomed Eng

PubMed ID: 36809393

Doi: 10.1007/s10439-023-03162-9

Products & Services: Molecular Biology Reagents

Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase

Authors: Nadine T Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F Lichtenthaler, Harald Steiner, Dieter Langosch

Journal: Commun Biol

PubMed ID: 36792683

Doi: 10.1038/s42003-023-04470-5

Products & Services: Gene Synthesis

CYCLIN-DEPENDENT KINASE 8 positively regulates oil synthesis by activating WRINKLED1 transcription

Authors: Zhiyang Zhai, Jantana K Blanford, Yingqi Cai, Jing Sun, Hui Liu, Hai Shi, Jorg Schwender, John Shanklin

Journal: New Phytol

PubMed ID: 36683527

Doi: 10.1111/nph.18764

Products & Services: Monoclonal Antibody Services

ACE2 binding and antibody evasion in enhanced transmissibility of XBB15

Authors: Can Yue, Weiliang Song, Lei Wang, Fanchong Jian, Xiaosu Chen, Fei Gao, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao