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Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes

Authors: Madeeha Ghazi, Shivangi Khanna, Yogaspoorthi Subramaniam, Jeyashri Rengaraju, Farina Sultan, Iti Gupta, Kanupriya Sharma, Sudhir Chandna, Rajesh S Gokhale, Vivek T Natarajan

Journal: Nucleic Acids Res

PubMed ID: 37697436

Doi: 10.1093/nar/gkad704

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A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

Authors: Lounis Yakhou, Anaelle Azogui, Nikhil Gupta, Julien Richard Albert, Fumihito Miura, Laure Ferry, Kosuke Yamaguchi, Sarah Battault, Pierre Therizols, Frédéric Bonhomme, Elouan Bethuel, Arpita Sarkar, Maxim V C Greenberg, Paola B Arimondo, Gael Cristofari, Olivier Kirsh, Takashi Ito, Pierre-Antoine Defossez

Journal: Nucleic Acids Res

PubMed ID: 37650637

Doi: 10.1093/nar/gkad719

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Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells

Authors: Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim

Journal: Nature

PubMed ID: 37880368

Doi: 10.1038/s41586-023-06676-3

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A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells

Authors: Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, Haiming Huang

Journal: Front Immunol

PubMed ID: 37954614

Doi: 10.3389/fimmu.2023.1292839

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Dual immunization with CdtB protein and flagellin epitope offers augmented protection against enteric fever in mice

Authors: Shania Vij, Reena Thakur, Raghwendra Pratap Singh, Rashmi Kumar, Preeti Pathania, Varsha Gupta, Chander Raman Suri, Praveen Rishi

Journal: Life Sci

PubMed ID: 37918629

Doi: 10.1016/j.lfs.2023.122216

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Therapeutic effect of exosomes derived from hepatocyte-growth-factor-overexpressing adipose mesenchymal stem cells on liver injury

Authors: Liushenyan Yu, Junchao Xue, Yanyan Wu, Hanyu Zhou

Journal: Folia Histochem Cytobiol

PubMed ID: 37787035

Doi: 10.5603/fhc.95291

Products & Services: Combinatorial Mutant library

Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients

Authors: Christa Lichtensteiger, Maximilian Koblischke, Fiamma Berner, Ann-Kristin Jochum, Tobias Sinnberg, Beatrice Balciunaite, Mette-Triin Purde, Vincent Walter, Marie-Therese Abdou, Kathrin Hofmeister, Philipp Kohler, Pietro Vernazza, Werner C Albrich, Christian R Kahlert, Alexander Zoufaly, Marianna T Traugott, Lukas Kern, Urs Pietsch, Gian-Reto Kleger, Miodrag Filipovic, Manfred Kneilling, Antonio Cozzio, Oltin Pop, David Bomze, Andreas Bergthaler, Omar Hasan Ali, Judith Aberle, Lukas Flatz

Journal: J Autoimmun

PubMed ID: 37826919

Doi: 10.1016/j.jaut.2023.103118

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A Polyvalent Adhesin-Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Adhesins (CS7, CS12, CS14, CS17, and CS21) but Not Enterotoxins (LT and STa)

Authors: Siqi Li, Hyesuk Seo, Ipshita Upadhyay, Weiping Zhang

Journal: Microorganisms

PubMed ID: 37894131

Doi: 10.3390/microorganisms11102473

Products & Services: Gene Synthesis

Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19

Authors: Gang Ye, Ruangang Pan, Fan Bu, Jian Zheng, Alise Mendoza, Wei Wen, Lanying Du, Benjamin Spiller, Brian E Wadzinski, Bin Liu, Stanley Perlman, Fang Li

Journal: J Virol

PubMed ID: 37855638

Doi: 10.1128/jvi.01448-23

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Varying the expression pattern of the strigolactone receptor gene results in phenotypes distinct from both wild type and knockout mutants

Authors: Revel S M Drummond, Hui Wen Lee, Zhiwei Luo, Jack F Dakin, Bart J Janssen, Kimberley C Snowden

Journal: Front Plant Sci

PubMed ID: 37900765

Doi: 10.3389/fpls.2023.1277617

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Improved prime editing allows for routine predictable gene editing in Physcomitrium patens

Authors: Pierre-François Perroud, Anouchka Guyon-Debast, Josep M Casacuberta, Wyatt Paul, Jean-Philippe Pichon, David Comeau, Fabien Nogué

Journal: J Exp Bot

PubMed ID: 37243510

Doi: 10.1093/jxb/erad189

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Structural and dynamical changes of the Streptococcus gordonii metalloregulatory ScaR protein induced by Mn ion binding

Authors: Katarina Radman, Zoe Jelić Matošević, Dijana Žilić, Ivo Crnolatac, Nikola Bregović, Marina Kveder, Ivo Piantanida, Pedro A Fernandes, Ivana Leščić Ašler, Branimir Bertoša

Journal: Int J Biol Macromol

PubMed ID: 37866578

Doi: 10.1016/j.ijbiomac.2023.127572

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The Functional Characteristics and Soluble Expression of Saffron CCD2

Authors: Ying Wang, Siqi Li, Ze Zhou, Lifen Sun, Jing Sun, Chuanpu Shen, Ranran Gao, Jingyuan Song, Xiangdong Pu

Journal: Int J Mol Sci

PubMed ID: 37894770

Doi: 10.3390/ijms242015090

Products & Services: Gene Synthesis

Electroacupuncture at GB20 improves cognitive ability and synaptic plasticity via the CaM-CaMKII-CREB signaling pathway following cerebral ischemia-reperfusion injury in rats

Authors: Qing Han, Feng Wang

Journal: Acupunct Med

PubMed ID: 38126262

Doi: 10.1177/09645284231202805

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Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization

Authors: Rajesh P Ringe, Philippe Colin, Gabriel Ozorowski, Joel D Allen, Anila Yasmeen, Gemma E Seabright, Jeong Hyun Lee, Aleksandar Antanasijevic, Kimmo Rantalainen, Thomas Ketas, John P Moore, Andrew B Ward, Max Crispin, P J Klasse

Journal: PLoS Pathog

PubMed ID: 37903160

Doi: 10.1371/journal.ppat.1011601

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VP2 residue N142 of coxsackievirus A10 is critical for the interaction with KREMEN1 receptor and neutralizing antibodies and the pathogenicity in mice

Authors: Xue Li, Zeyu Liu, Xingyu Yan, Yuan Tian, Kexin Liu, Yue Zhao, Jiang Shao, Pei Hao, Chao Zhang

Journal: PLoS Pathog

PubMed ID: 37788227

Doi: 10.1371/journal.ppat.1011662

Products & Services: Protein and Antibody Isolation

One ring closer to a closure: the crystal structure of the ES hydroxymethylbilane synthase intermediate

Authors: Helene J Bustad, Marthe S Christie, Mikko Laitaoja, Aasne K Aarsand, Aurora Martinez, Janne Jänis, Juha P Kallio

Journal: FEBS J

PubMed ID: 37863644

Doi: 10.1111/febs.16982

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Diversity of rhodopsin cyclases in zoospore-forming fungi

Authors: Matthias Broser, Wayne Busse, Anika Spreen, Maila Reh, Yinth Andrea Bernal Sierra, Songhwan Hwang, Tillmann Utesch, Han Sun, Peter Hegemann

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37871207

Doi: 10.1073/pnas.2310600120

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Vγ9+Vδ2+ T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes

Authors: Katrin Fischer, Michaela Bradlerova, Thomas Decker, Verena Supper

Journal: Sci Rep

PubMed ID: 37903831

Doi: 10.1038/s41598-023-45587-1

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New twists of a TAIL: novel insights into the histone binding properties of a highly conserved PHD finger cluster within the MLR family of H3K4 mono-methyltransferases

Authors: Claudia B Zraly, Richard Schultz, Manuel O Diaz, Andrew K Dingwall

Journal: Nucleic Acids Res

PubMed ID: 37638761

Doi: 10.1093/nar/gkad698

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Construction and functional verification of size-reduced plasmids based on TMP resistance gene

Authors: Chun-Cao Li, Rui Hu, Xiu-Min Hua, Yi-Xuan Ni, Lu Ge, Lu Zhang, Wen Yu, Ni-Xin Hao, Hui Xia, Qiang Fang, Zhi-Yong Tao

Journal: Microbiol Spectr

PubMed ID: 37905802

Doi: 10.1128/spectrum.01206-23

Products & Services: Plasmid DNA Preparation

STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1

Authors: Deli Song, Xudong Jia, Yuanzhu Gao, Tong Xiao, Jia Dan, Runling Shen, Jing Cai, Jiankai Liang, Wenbo Zhu, Jun Hu, Guangmei Yan, Qinfen Zhang, Yuan Lin

Journal: Oncogene

PubMed ID: 37864032

Doi: 10.1038/s41388-023-02872-7

Products & Services: Molecular Biology Reagents

Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis

Authors: Alžběta Motyčková, Luboš Voleman, Vladimíra Najdrová, Lenka Arbonová, Martin Benda, Vít Dohnálek, Natalia Janowicz, Ronald Malych, Róbert Šuťák, Thijs J G Ettema, Staffan Svärd, Courtney W Stairs, Pavel Doležal

Journal: PLoS Pathog

PubMed ID: 37792908

Doi: 10.1371/journal.ppat.1010773

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Acrylamide induces neurotoxicity in zebrafish (Danio rerio) via NLRP3-mediated pyroptosis

Authors: Boya Zhang, Mengyao Zhao, Xiaoguo Ji, Quanming Xia, Lihua Jiang, Liming Zhao

Journal: Science of The Total Environment

PubMed ID: 37392875

Doi: 10.1016/j.scitotenv.2023.165208

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miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells

Authors: Qihui Jia, Yuzhu Cao, Mengmeng Zhang, Yuxin Xing, Tian Xia, Yulong Guo, Yaxin Yue, Xin Li, Xiaojun Liu, Yanhua Zhang, Donghua Li, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Hong Li

Journal: Poult Sci

PubMed ID: 37939591

Doi: 10.1016/j.psj.2023.103200

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Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis

Authors: Wei Zhang, Zhuo Wan, Di Qu, Wenqi Sun, Liang Zhang, Yuan Liang, Lei Pan, Hua Jiang, Zichen Ye, Mengying Wei, Lijun Yuan, Guodong Yang, Faguang Jin

Journal: Bioact Mater

PubMed ID: 37965241

Doi: 10.1016/j.bioactmat.2023.09.019

Products & Services: Gene Synthesis

Inherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein

Authors: Norio Motohashi, Katsura Minegishi, Yoshitsugu Aoki

Journal: Cell Death Dis

PubMed ID: 37857600

Doi: 10.1038/s41419-023-06192-2

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Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness

Authors: Shengmiao Chen, Yiran Wu, Yang Gao, Chenxu Wu, Yuetong Wang, Chun Hou, Miao Ren, Shuyuan Zhang, Qi Zhu, Jiali Zhang, Yufeng Yao, Mei Huang, Yingchuan B Qi, Xue-Song Liu, Tiffany Horng, Haopeng Wang, Dan Ye, Zhengjiang Zhu, Suwen Zhao, Gaofeng Fan

Journal: Cell Rep

PubMed ID: 37831605

Doi: 10.1016/j.celrep.2023.113246

Products & Services: Molecular Biology Reagents

Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma

Authors: Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang, Tingting Zhao, Shihui Zhang, Yong Lin, Hongzhou Zhao, Yongpan Liu, Yuxuan Wei, Yijian Zhou, Jiaying Zhang, Xianzong Ye, Jing Zhao, Xinxin Li, Jianwen Que, Songlin Shi, Kuancan Liu

Journal: Cell Death Discov

PubMed ID: 37891174

Doi: 10.1038/s41420-023-01693-7

Products & Services: Molecular Biology Reagents

Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis

Authors: Mengmeng Liang, Ke Wang, Xiaoyu Wei, Xiaoshan Gong, Hao Tang, Hao Xue, Jing Wang, Pengbin Yin, Licheng Zhang, Zaisong Ma, Ce Dou, Shiwu Dong, Jianzhong Xu, Fei Luo, Qinyu Ma

Journal: Cell Rep Med

PubMed ID: 37852176

Doi: 10.1016/j.xcrm.2023.101228

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Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity

Authors: Sigrun K Maurer, Matthias P Mayer, Stephanie J Ward, Sana Boudjema, Mohamed Halawa, Jiatong Zhang, Simon G Caulton, Jonas Emsley, Ingrid Dreveny

Journal: J Biol Chem

PubMed ID: 37777157

Doi: 10.1016/j.jbc.2023.105300

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LMNB1 targets FOXD1 to promote progression of prostate cancer

Authors: Yuanshe Huang, Lai Zhang, Tianlei Liu, E Liang

Journal: Exp Ther Med

PubMed ID: 37840569

Doi: 10.3892/etm.2023.12212

Products & Services: Protein and Antibody Isolation

Inhibitory effect of Eimeria maxima IFN-γ inhibitory molecules on the immune function of T cell subsets in chickens

Authors: Xianglin Pu, Yangdong Pan, Quanjia Xiang, Mingmin Lu, Lixin Xu, Ruofeng Yan, Xiangrui Li, Xiaokai Song

Journal: Poult Sci

PubMed ID: 37797491

Doi: 10.1016/j.psj.2023.103098

Products & Services: Protein and Antibody Isolation

ActuAtor, a Listeria-inspired molecular tool for physical manipulation of intracellular organizations through de novo actin polymerization

Authors: Hideki Nakamura, Elmer Rho, Christopher T Lee, Kie Itoh, Daqi Deng, Satoshi Watanabe, Shiva Razavi, Hideaki T Matsubayashi, Cuncheng Zhu, Eleanor Jung, Padmini Rangamani, Shigeki Watanabe, Takanari Inoue

Journal: Cell Rep

PubMed ID: 37734382

Doi: 10.1016/j.celrep.2023.113089

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Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking

Authors: Lihong Liu, Ryan G Casner, Yicheng Guo, Qian Wang, Sho Iketani, Jasper Fuk-Woo Chan, Jian Yu, Bernadeta Dadonaite, Manoj S Nair, Hiroshi Mohri, Eswar R Reddem, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kwok-Yung Yuen, Zizhang Sheng, Yaoxing Huang, Jesse D Bloom, Lawrence Shapiro, David D Ho

Journal: Immunity

PubMed ID: 37776849

Doi: 10.1016/j.immuni.2023.09.003

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Next step in the development of mesoprogestins: the preclinical profile of EC313

Authors: K Błaszczak-Świątkiewicz, A Krupa, E Mnich, W Elger, M Oettel, H Nair, M Wierzbicki, P Sieroszewski, Z Shaked

Journal: Front Endocrinol (Lausanne)

PubMed ID: 37766684

Doi: 10.3389/fendo.2023.1201547

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The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence

Authors: Cameron P Gill, Christopher Phan, Vivien Platt, Danielle Worrell, Thomas Andl, Hervé Roy

Journal: Microbiol Spectr

PubMed ID: 37768052

Doi: 10.1128/spectrum.01429-23

Products & Services: Protein and Antibody Isolation

Single-Dose Intranasal Immunisation with Novel Chimeric H1N1 Expressing the Receptor-Binding Domain of SARS-CoV-2 Induces Robust Mucosal Immunity, Tissue-Resident Memory T Cells, and Heterologous Protection in Mice

Authors: Donghong Wang, Yao Deng, Jianfang Zhou, Wen Wang, Baoying Huang, Wenling Wang, Lan Wei, Jiao Ren, Ruiwen Han, Jialuo Bing, Chengcheng Zhai, Xiaoyan Guo, Wenjie Tan

Journal: Vaccines (Basel)

PubMed ID: 37766130

Doi: 10.3390/vaccines11091453

Products & Services: Protein and Antibody Isolation

A conserved N protein nano-vaccine of COVID-19 exerts potent and cross-reactive humoral and cellular immune responses in mice

Authors: Bing Li, Jing Zhang, Yang Huang, Xinrui Li, Jing Feng, Yan Li, Rongxin Zhang

Journal: J Med Virol

PubMed ID: 37750245

Doi: 10.1002/jmv.29115

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Clinical Course, Immunogenicity, and Efficacy of BNT162b2 mRNA Vaccination Against SARS-CoV-2 Infection in Liver Transplant Recipients

Authors: Eunice X Tan, Wen Hui Lim, Elizabeth Thong, Jean-Marc Chavatte, Jinyan Zhang, Jonathan Lim, Jocelyn Y Jin, Daniel R X Lim, Jaclyn Y T Kang, Ansel Shao Pin Tang, Kai En Chan, Caitlyn Tan, Shi Ni Tan, Benjamin Nah, Daniel Q Huang, Lin-Fa Wang, Paul A Tambyah, Jyoti Somani, Barnaby Young, Mark D Muthiah

Journal: Transplant Direct

PubMed ID: 37745946

Doi: 10.1097/TXD.0000000000001537

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Camel nanobody-based B7-H3 CAR-T cells show high efficacy against large solid tumours

Authors: Dan Li, Ruixue Wang, Tianyuzhou Liang, Hua Ren, Chaelee Park, Chin-Hsien Tai, Weiming Ni, Jing Zhou, Sean Mackay, Elijah Edmondson, Javed Khan, Brad St Croix, Mitchell Ho

Journal: Nat Commun

PubMed ID: 37739951

Doi: 10.1038/s41467-023-41631-w

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Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison

Authors: Inge Kroidl, Simon Winter, Raquel Rubio-Acero, Abhishek Bakuli, Christof Geldmacher, Tabea M Eser, Flora Déak, Sacha Horn, Anna Zielke, Mohamed I M Ahmed, Paulina Diepers, Jessica Guggenbühl, Jonathan Frese, Jan Bruger, Kerstin Puchinger, Jakob Reich, Philine Falk, Alisa Markgraf, Heike Fensterseifer, Ivana Paunovic, Angelika Thomschke, Michael Pritsch, Friedrich Riess, Elmar Saathoff, Michael Hoelscher, Laura Olbrich, Noemi Castelletti, Andreas Wieser

Journal: Virol J

PubMed ID: 37658454

Doi: 10.1186/s12985-023-02167-z

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Ameliorative effect of Alangium chinense (Lour) Harms on rheumatoid arthritis by reducing autophagy with targeting regulate JAK3-STAT3 and COX-2 pathways

Authors: Ting Xiao, Xingyan Cheng, Yuan Zhi, Fangfang Tian, Ai Wu, Feilong Huang, Ling Tao, Zhenghong Guo, Xiangchun Shen

Journal: J Ethnopharmacol

PubMed ID: 37690476

Doi: 10.1016/j.jep.2023.117133

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Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake

Authors: Rodger de Miranda, Bonnie J Cuthbert, Thaís Klevorn, Alex Chao, Jessica Mendoza, Mark Arbing, Paul J Sieminski, Kadamba Papavinasasundaram, Sumer Abdul-Hafiz, Sum Chan, Christopher M Sassetti, Sabine Ehrt, Celia W Goulding

Journal: PLoS Pathog

PubMed ID: 37747938

Doi: 10.1371/journal.ppat.1011650

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Listeria-based vaccination against the pericyte antigen RGS5 elicits anti-vascular effects and colon cancer protection

Authors: Trevor S Anderson, Amanda L McCormick, Elizabeth A Daugherity, Mariam Oladejo, Izuchukwu F Okpalanwaka, Savanna L Smith, Duke Appiah, Laurence M Wood, Devin B Lowe

Journal: Oncoimmunology

PubMed ID: 37781234

Doi: 10.1080/2162402X.2023.2260620

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Lactiplantibacillus plantarum as a novel platform for production and purification of integral membrane proteins using RseP as the benchmark

Authors: Sofie S Kristensen, Marie V Lukassen, Suzana Siebenhaar, Dzung B Diep, J Preben Morth, Geir Mathiesen

Journal: Sci Rep

PubMed ID: 37658186

Doi: 10.1038/s41598-023-41559-7

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Engineering gain-of-function mutants of a WW domain by dynamics and structural analysis

Authors: Jin Lu, Mohammad Imtiazur Rahman, I Can Kazan, Nicholas R Halloran, Andrey A Bobkov, S Banu Ozkan, Giovanna Ghirlanda