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A non-toxic recombinant bivalent chimeric protein rETXCSA as a potential vaccine candidate against enterotoxemia and braxy
Authors: Jige Du, Bo Liu, Tuanjie Wang, Zhen Zhu, Chunsheng Yin, Yufeng Luo, Ying Liu, Xiaoyun Chen
Journal: Vaccine
PubMed ID: 36635138
Doi: 10.1016/j.vaccine.2022.11.021
Products & Services: Molecular Biology Reagents   
Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees
Authors: Pei Yu, Zijian Liu, Zhuoqi Zhu, Jiaqing Yang, Min Deng, Mingxiao Chen, Changchun Lai, Weiya Kong, Shilong Xiong, Li Wan, Weikang Mai, Lu Chen, Yu Lei, Shahzad Akbar Khan, Jianfeng Ruan, An Kang, Xuguang Guo, Qiang Zhou, Wenrui Li, Zheng Chen, Yuemei Liang, Pingchao Li, Lei Zhang, Tianxing Ji
Journal: Virol Sin
PubMed ID: 36603767
Doi: 10.1016/j.virs.2022.12.008
Products & Services: Molecular Biology Reagents   
Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern
Authors: Steven Y Gao, Nancy B Amaro-Mugridge, Jocelyn Madrid-Weiss, Nikolina Petkovic, Natasha Vanegas, Kumar Visvanathan, Bryan R G Williams, Jennifer A MacDiarmid, Himanshu Brahmbhatt
Journal: Front Immunol
PubMed ID: 36818474
Doi: 10.3389/fimmu.2022.1038562
Products & Services: Molecular Biology Reagents   
Detection and Molecular Characterization of the SARS-CoV-2 Delta Variant and the Specific Immune Response in Companion Animals in Switzerland
Authors: Evelyn Kuhlmeier, Tatjana Chan, Cecilia Valenzuela Agüí, Barbara Willi, Aline Wolfensberger, Christian Beisel, Ivan Topolsky, Niko Beerenwinkel, Tanja Stadler, Sarah Jones, Grace Tyson, Margaret J Hosie, Katja Reitt, Julia Hüttl, Marina L Meli, Regina Hofmann-Lehmann
Journal: Viruses
PubMed ID: 36680285
Doi: 10.3390/v15010245
Defending against SARS-CoV-2: The T cell perspective
Authors: Patricia Almendro-Vázquez, Rocío Laguna-Goya, Estela Paz-Artal
Journal: Front Immunol
PubMed ID: 36776863
Doi: 10.3389/fimmu.2023.1107803
Products & Services: Gene Synthesis   
Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Authors: Dario Gerace, Quan Zhou, Jennifer Hyoje-Ryu Kenty, Adrian Veres, Elad Sintov, Xi Wang, Kyle R Boulanger, Hongfei Li, Douglas A Melton
Journal: Cell Rep Med
PubMed ID: 36599351
Doi: 10.1016/j.xcrm.2022.100879
Products & Services: Peptide Synthesis   
Low-cost and prototype-friendly method for biocompatible encapsulation of implantable electronics with epoxy overmolding, hermetic feedthroughs and P3HT coating
Authors: Marek Novák, Jozef Rosina, Hana Bendová, Kristina Kejlová, Alena Vlková, Marian Rucki, Lada Svobodová, Robert Gürlich, Jan Hajer
Journal: Sci Rep
PubMed ID: 36717683
Doi: 10.1038/s41598-023-28699-6
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Dependency of sanitation infrastructure on the discharge of faecal coliform and SARS-CoV-2 viral RNA in wastewater from COVID and non-COVID hospitals in Dhaka, Bangladesh
Authors: Nuhu Amin, Rehnuma Haque, Md Ziaur Rahman, Mohammed Ziaur Rahman, Zahid Hayat Mahmud, Rezaul Hasan, Md Tahmidul Islam, Protim Sarker, Supriya Sarker, Shaikh Daud Adnan, Nargis Akter, Dara Johnston, Mahbubur Rahman, Pengbo Liu, Yuke Wang, Tahmina Shirin, Mahbubur Rahman, Prosun Bhattacharya
Journal: Sci Total Environ
PubMed ID: 36623655
Doi: 10.1016/j.scitotenv.2023.161424
Products & Services: Custom DNA/RNA Oligos   
Exploiting natural riboswitches for aptamer engineering and validation
Authors: Michael G Mohsen, Matthew K Midy, Aparaajita Balaji, Ronald R Breaker
Journal: Nucleic Acids Res
PubMed ID: 36617976
Doi: 10.1093/nar/gkac1218
Products & Services: CRISPR Plasmids   
Monosynaptic restriction of the anterograde herpes simplex virus strain H129 for neural circuit tracing
Authors: Kyle B Fischer, Hannah K Collins, Yan Pang, Dheeraj S Roy, Ying Zhang, Guoping Feng, Shu-Jing Li, Adam Kepecs, Edward M Callaway
Journal: J Comp Neurol
PubMed ID: 36606699
Doi: 10.1002/cne.25451
Products & Services: Molecular Biology Reagents   
Evaluation of a biotin-based surrogate virus neutralization test for detecting postvaccination antibodies against SARS-CoV-2 variants in sera
Authors: Min-Ju Ahn, Jung-Ah Kang, Su Min Hong, Kyu-Sun Lee, Dong Ho Kim, Daesub Song, Dae Gwin Jeong
Journal: Biochem Biophys Res Commun
PubMed ID: 36696754
Doi: 10.1016/j.bbrc.2023.01.052
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PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer
Authors: Chakravarthy Garlapati, Shriya Joshi, Shristi Bhattarai, Jayashree Krishnamurthy, Ravi Chakra Turaga, Thi Nguyen, Xiaoxian Li, Ritu Aneja
Journal: Cell Death Dis
PubMed ID: 36627281
Doi: 10.1038/s41419-022-05539-5
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Pold4 is dispensable for mouse development, DNA replication and DNA repair
Authors: Xueping Gu , Qinjin Dai , Peng Du , Ning Li , Jiahui Li , Simiao Zeng , Shuyi Peng , Shengjun Tang , Lei Wang , Zhongcheng Zhou
Journal: Gene
PubMed ID: 36356905
Doi: 10.1016/j.gene.2022.147029
Expression and kinetic characterization of PYCR3 Kaylen
Authors: Kaylen R Meeks , John J Tanner
Journal: Arch Biochem Biophys
PubMed ID: 36414121
Doi: 10.1016/j.abb.2022.109468
Products & Services: Codon Optimization   
Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors
Authors: Chunrong Yang , Yuchen Yang , Yujie Li , Qiankun Ni , Jinghong Li
Journal: J Am Chem Soc.
PubMed ID: 36542856
Doi: 10.1021/jacs.2c10177
RsCLE22a regulates taproot growth through an auxin signaling-related pathway in radish (Raphanus sativus L)
Authors: Junhui Dong, Yan Wang, Liang Xu, Bingshuang Li, Kai Wang, Jiali Ying, Qing He, Liwang Liu
Journal: J Exp Bot
PubMed ID: 36239471
Doi: 10.1093/jxb/erac406
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Atlantic cod () MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals
Authors: Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida
Journal: Front Cell Dev Biol
PubMed ID: 36760361
Doi: 10.3389/fcell.2023.1050323
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Linoleic acid ameliorates intestinal mucosal barrier injury in early weaned pigeon squabs (Columba livia)
Authors: Qianqian Xu, Jin Zhao, Huafeng Jian, Jiangcheng Ye, Mingxiu Gong, Xiaoting Zou, Xinyang Dong
Journal: J Anim Sci
PubMed ID: 37186172
Doi: 10.1093/jas/skad125
Mesenchymal stem cell-derived extracellular vesicles transfer miR-598 to inhibit the growth and metastasis of non-small-cell lung cancer by targeting THBS2
Authors: Xuebo Li, Fan Wu
Journal: Cell Death Discov
PubMed ID: 36609437
Doi: 10.1038/s41420-022-01283-z
Products & Services: Custom DNA/RNA Oligos   
Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates
Authors: Daehun Park, Yumei Wu, Xinbo Wang, Swetha Gowrishankar, Aaron Baublis, Pietro De Camilli
Journal: Nat Commun
PubMed ID: 36709207
Doi: 10.1038/s41467-023-36081-3
Products & Services: Custom Vector Construction   
CRISPR mediated transactivation in the human disease vector Aedes aegypti
Authors: Michelle Bui, Elena Dalla Benetta, Yuemei Dong, Yunchong Zhao, Ting Yang, Ming Li, Igor A Antoshechkin, Anna Buchman, Vanessa Bottino-Rojas, Anthony A James, Michael W Perry, George Dimopoulos, Omar S Akbari
Journal: PLoS Pathog
PubMed ID: 36656895
Doi: 10.1371/journal.ppat.1010842
A method for mapping the linear epitopes targeted by the natural antibody response to Zika virus infection using a VLP platform technology
Authors: Alexandra Fowler, Chunyan Ye, Elizabeth C Clarke, Juan M Pascale, David S Peabody, Steven B Bradfute, Kathryn M Frietze, Bryce Chackerian
Journal: Virology
PubMed ID: 36623351
Doi: 10.1016/j.virol.2023.01.001
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SARS-CoV-2-free residual proteins mediated phenotypic and metabolic changes in peripheral blood monocytic-derived macrophages in support of viral pathogenesis
Authors: Mohammad G Mohammad, Naglaa S Ashmawy, Ahmed M Al-Rawi, Ameera Abu-Qiyas, Alshaimaa M Hamoda, Rania Hamdy, Salam Dakalbab, Shahad Arikat, Dana Salahat, Mohamed Madkour, Sameh S M Soliman
Journal: PLoS ONE
PubMed ID: 36656874
Doi: 10.1371/journal.pone.0280592
Products & Services: Molecular Biology Reagents   
RACK1 release from the Ribosome Couples Translational Regulation with Starving Signaling and Possibly Depends on Phosphorylation of Key Serine and Threonine Residues
Authors: Maria Kiratzis, Giancarlo Lai, Piera Calamita, Marilena Mancino, Marcello Iriti, Nicola Manfrini, Simone Gallo
Journal: Cell Mol Biol (Noisy-le-grand)
PubMed ID: 37213164
Doi: 10.14715/cmb/2022.69.1.2
Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal
Authors: Mikayla Hoad, Emily M Cross, Camilla M Donnelly, Subir Sarker, Justin A Roby, Jade K Forwood
Journal: Viruses
PubMed ID: 36851528
Doi: 10.3390/v15020315
Maltose-Enhanced Exopolysaccharide Synthesis of through CRP-like Protein
Authors: Fanqiang Meng, Yunbin Lyu, Xiaoyu Chen, Fengxia Lu, Haizhen Zhao, Yingjian Lu, Mingwen Zhao, Zhaoxin Lu
Journal: J Agric Food Chem
PubMed ID: 36602107
Doi: 10.1021/acs.jafc.2c07880
Loss-of-function KCa2.2 mutations abolish channel activity
Authors: Young-Woo Nam , Mohammad Asikur Rahman , Grace Yang , Razan Orfali , Meng Cui , Miao Zhang
Journal: Am J Physiol Cell Physiol
PubMed ID: 36717104
Doi: 10.1152/ajpcell.00584.2022
Products & Services: PCR Cloning and Subcloning   
Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus
Authors: Laura Sandra Lello, Agneta Miilimäe, Liubov Cherkashchenko, Ailar Omler, Rachel Skilton, Rachel Ireland, David Ulaeto, Andres Merits
Journal: J Virol
PubMed ID: 36533950
Doi: 10.1128/jvi.01368-22
Products & Services: Gene Synthesis   
Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Authors: Sangwook Oh, Xuming Mao, Silvio Manfredo-Vieira, Jinmin Lee, Darshil Patel, Eun Jung Choi, Andrea Alvarado, Ebony Cottman-Thomas, Damian Maseda, Patricia Y Tsao, Christoph T Ellebrecht, Sami L Khella, David P Richman, Kevin C O'Connor, Uri Herzberg, Gwendolyn K Binder, Michael C Milone, Samik Basu, Aimee S Payne
Journal: Nat Biotechnol
PubMed ID: 36658341
Doi: 10.1038/s41587-022-01637-z
Circ-N4BP2L2 enhances mitochondrial function in non-small cell lung cancer cells through regulating the miR-135a-5p/ARL5B axis
Authors: Hongyang Shi, Yuqiang Ji, Yonghong Zhang, Yu Wang, Wei Li
Journal: Environ Toxicol
PubMed ID: 36637163
Doi: 10.1002/tox.23736
Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines
Authors: Stephen J Staklinski, Mario C Chang, Rebecca C Ahrens-Nicklas, Shagun Kaur, Arianna K Stefanatos, Elizabeth E Dudenhausen, Matthew E Merritt, Michael S Kilberg
Journal: JIMD Rep
PubMed ID: 36873094
Doi: 10.1002/jmd2.12356
Products & Services: Molecular Biology Reagents   
Magnaporthe oryzae pathotype Triticum (MoT) can act as a heterologous expression system for fungal effectors with high transcript abundance in wheat
Authors: Cassandra Jensen, Diane G O Saunders
Journal: Sci Rep
PubMed ID: 36596834
Doi: 10.1038/s41598-022-27030-z
Products & Services: Peptide Synthesis   
Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W
Authors: Jia Zang, Yulin Chen, Chao Liu, Linzhen Hu, Hongxia Zhao, Wenlong Ding, Ying Yuan, Shixian Lin
Journal: Nat Struct Mol Biol
PubMed ID: 36593310
Doi: 10.1038/s41594-022-00866-9
Label-free impedimetric immunosensor for point-of-care detection of COVID-19 antibodies
Authors: Lian C T Shoute, Gaser N Abdelrasoul, Yuhao Ma, Pedro A Duarte, Cole Edwards, Ran Zhuo, Jie Zeng, Yiwei Feng, Carmen L Charlton, Jamil N Kanji, Shawn Babiuk, Jie Chen
Journal: Microsyst Nanoeng
PubMed ID: 36597510
Doi: 10.1038/s41378-022-00460-5
Products & Services: PCR Cloning and Subcloning   
Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats
Authors: NicolasG.Glynos, Lily Carter, Soo Jung Lee, Youngsoo Kim , RobertT. Kennedy, GeorgeA. Mashour, Michael M. Wang & Jimo Borjigin
Journal: Scientific Reports
PubMed ID: 36609666
Products & Services: Polyclonal Antibody Services   
The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae
Authors: Giovanni Covaleda-Cortés, Ariel Mechaly, Terry Brissac, Heike Baehre, Laura Devaux, Patrick England, Bertrand Raynal, Sylviane Hoos, Myriam Gominet, Arnaud Firon, Patrick Trieu-Cuot, Pierre Alexandre Kaminski
Journal: FEBS J
PubMed ID: 36629470
Doi: 10.1111/febs.16724
Products & Services: Molecular Biology Reagents   
Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q133 microdeletion syndrome
Authors: Brianna K Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W Doble, Laurence Faivre, Antonio Vitobello, Stephen W Scherer, Yu Lu, Peter Penzes, Karun K Singh
Journal: Mol Psychiatry
PubMed ID: 36604605
Doi: 10.1038/s41380-022-01937-5
Products & Services: DNA Sequencing   
Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro
Authors: Liyin Wang, Xin Yu, Dongyan Zhang, Yingying Wen, Liyue Zhang, Yutong Xia, Jinbo Chen, Chen Xie, Hong Zhu, Jianping Tong, Ye Shen
Journal: J Photochem Photobiol B
PubMed ID: 36724628
Doi: 10.1016/j.jphotobiol.2023.112654
Functional Impact of a Cancer-Related Variant in Human Δ1-Pyrroline-5-Carboxylate Reductase 1
Authors: Oseeyi I Daudu , Kaylen R Meeks , Lu Zhang , Javier Seravalli , John J Tanner , Donald F Becker
Journal: ACS Omega .
PubMed ID: 36713721
Doi: 10.1021/acsomega.2c07788
Products & Services: Mutagenesis Services   
The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer
Authors: Xue Yang, Miguel I Cruz, Elizabeth V Nguyen, Cheng Huang, Ralf B Schittenhelm, Jennii Luu, Karla J Cowley, Sung-Young Shin, Lan K Nguyen, Terry C C Lim Kam Sian, Kimberley C Clark, Kaylene J Simpson, Xiuquan Ma, Roger J Daly
Journal: Oncogene
PubMed ID: 36693952
Doi: 10.1038/s41388-023-02594-w
Impacts of delta and omicron variants on inactivated SARS-CoV-2 vaccine-induced T cell responses in patients with autoimmune diseases and healthy controls
Authors: Shuyi Wang, Jin Li, Shuang Wang, Yujin Ye, Mengyuan Li, Yihao Liu, Binfeng Chen, Yimei Lai, Liubing Li, Lili Zhuang, Sui Peng, Niansheng Yang, Hui Zhang, Haipeng Xiao
Journal: Clin Transl Med
PubMed ID: 36639826
Doi: 10.1002/ctm2.1171
Products & Services: Peptide Synthesis   
Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs
Authors: John P Finnigan, Jenna H Newman, Yury Patskovsky, Larysa Patskovska, Andrew S Ishizuka, Geoffrey M Lynn, Robert A Seder, Michelle Krogsgaard, Nina Bhardwaj
Journal: Res Sq
PubMed ID: 36778273
Doi: 10.21203/rs.3.rs-2531184/v1
New Synthetic Operon Vectors for Expressing Multiple Proteins in the Chloroplast
Authors: Jihye Yeon, Stephen M Miller, Wipawee Dejtisakdi
Journal: Genes (Basel)
PubMed ID: 36833295
Doi: 10.3390/genes14020368
Products & Services: Molecular Biology Reagents   
Delineation of the CYP505E subfamily of fungal self-sufficient in-chain hydroxylating cytochrome P450 monooxygenases
Authors: Martha Sophia Smit, Mpeyake Jacob Maseme, Jacqueline van Marwijk, Jasmin Cara Aschenbrenner, Diederik Johannes Opperman
Journal: Appl Microbiol Biotechnol
PubMed ID: 36607403
Doi: 10.1007/s00253-022-12329-8
Products & Services: Molecular Biology Reagents   
Ensemble-based, high-throughput virtual screening of potential inhibitor targeting putative farnesol dehydrogenase of Metisa plana (Lepidoptera: Psychidae)
Authors: Anis Nadyra Zifruddin, Mohamad Ariff Mohamad Yusoff, Nur Syatila Abd Ghani, Nor Azlan Nor Muhammad, Kok Wai Lam, Maizom Hassan
Journal: Comput Biol Chem
PubMed ID: 36645937
Doi: 10.1016/j.compbiolchem.2023.107811
Products & Services: DNA Sequencing   
An OsPRMT5-OsAGO2/miR1875-OsHXK1 module regulates rice immunity to blast disease
Authors: Cong Sheng, Xuan Li, Shengge Xia, Yimai Zhang, Ze Yu, Cheng Tang, Le Xu, Zhaoyun Wang, Xin Zhang, Tong Zhou, Pingping Nie, Ayesha Baig, Dongdong Niu, Hongwei Zhao
Journal: J Integr Plant Biol
PubMed ID: 36511124
Doi: 10.1111/jipb.13430
Performance evaluation of the Ortho VITROS SARS-CoV-2 Spike-Specific Quantitative IgG test by comparison with the surrogate virus neutralizing antibody test and clinical assessment
Authors: Maika Takahashi, Kaori Saito, Tomohiko Ai, Shuko Nojiri, Abdullah Khasawneh, Faith Jessica Paran, Yuki Horiuchi, Satomi Takei, Takamasa Yamamoto, Mitsuru Wakita, Makoto Hiki, Takashi Miida, Toshio Naito, Kazuhisa Takahashi, Yoko Tabe
Journal: PLoS ONE
PubMed ID: 36693058
Doi: 10.1371/journal.pone.0279779
Products & Services: Monoclonal Antibody Services   
Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters
Authors: Bart Nieuwenhuis, Elise Laperrousaz, James R Tribble, Joost Verhaagen, James W Fawcett, Keith R Martin, Pete A Williams, Andrew Osborne
Journal: Gene Ther
PubMed ID: 36635457
Doi: 10.1038/s41434-022-00380-z
Products & Services: Plasmid DNA Preparation   
Structural domains of SARS-CoV-2 nucleocapsid protein coordinate to compact long nucleic acid substrates
Authors: Michael Morse, Jana Sefcikova, Ioulia Rouzina, Penny J Beuning, Mark C Williams
Journal: Nucleic Acids Res
PubMed ID: 36533523
Doi: 10.1093/nar/gkac1179
Products & Services: Recombinant Proteins   
Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium
Authors: Heather M Callaway, Kathryn M Hastie, Sharon L Schendel, Haoyang Li, Xiaoying Yu, Jeremy Shek, Tierra Buck, Sean Hui, Dan Bedinger, Camille Troup, S Moses Dennison, Kan Li, Michael D Alpert, Charles C Bailey, Sharon Benzeno, Jody L Bonnevier, Jin-Qiu Chen, Charm Chen, Hyeseon Cho, Peter D Crompton, Vincent Dussupt, Kevin C Entzminger, Yassine Ezzyat, Jonathan K Fleming, Nick Geukens, Amy E Gilbert, Yongjun Guan, Xiaojian Han, Christopher J Harvey, Julia M Hatler, Bryan Howie, Chao Hu, Ailong Huang, Maya Imbrechts, Aishun Jin, Nik Kamachi, Gladys Keitany, Mark Klinger, Jay K Kolls, Shelly J Krebs, Tingting Li, Feiyan Luo, Toshiaki Maruyama, Michael A Meehl, Letzibeth Mendez-Rivera, Andrea Musa, C J Okumura, Benjamin E R Rubin, Aaron K Sato, Meiying Shen, Anirudh Singh, Shuyi Song, Joshua Tan, Jeffrey M Trimarchi, Dhruvkumar P Upadhyay, Yingming Wang, Lei Yu, Tom Z Yuan, Erik Yusko, Bjoern Peters, Georgia Tomaras, Erica Ollmann Saphire
Journal: Cell Rep
PubMed ID: 36681898
Doi: 10.1016/j.celrep.2023.112014
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