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A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT)

Authors: Li Chen, Yikai Lu, Mengmeng Zhao, Junfang Xu, Yan Wang, Qinghua Xu, Yajuan Cao, Haipeng Liu

Journal: J Gene Med

PubMed ID: 37897251

Doi: 10.1002/jgm.3612

Products & Services: Protein and Antibody Isolation

PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes

Authors: Binglin Zhu, Emily Fisher, Li Li, Ping Zhong, Zhen Yan, Jian Feng

Journal: Stem Cell Reports

PubMed ID: 37832540

Doi: 10.1016/j.stemcr.2023.09.012

Products & Services: Molecular Biology Reagents

Hem25p is required for mitochondrial IPP transport in fungi

Authors: Jonathan Tai, Rachel M Guerra, Sean W Rogers, Zixiang Fang, Laura K Muehlbauer, Evgenia Shishkova, Katherine A Overmyer, Joshua J Coon, David J Pagliarini

Journal: Nat Cell Biol

PubMed ID: 37813972

Doi: 10.1038/s41556-023-01250-5

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Modular multiwell viscoelastic hydrogel platform for two- and three-dimensional cell culture applications

Authors: Mackenzie L Skelton, James L Gentry, Leilani R Astrab, Joshua A Goedert, E Brynn Earl, Emily L Pham, Tanvi Bhat, Steven R Caliari

Journal: biorxiv

PubMed ID: 37873098

Doi: 10.1101/2023.10.09.561449

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Tafluprost promotes axon regeneration after optic nerve crush via Zn-mTOR pathway

Authors: Siting Wu, Canying Liu, Jiahui Tang, Caiqing Wu, Qi Zhang, Zhe Liu, Jiaxu Han, Jingfei Xue, Jicheng Lin, Yuze Chen, Jinpeng Yang, Yehong Zhuo, Yiqing Li

Journal: Neuropharmacology

PubMed ID: 37832634

Doi: 10.1016/j.neuropharm.2023.109746

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Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute

Authors: Xiaopan Gao, Kun Shang, Kaixiang Zhu, Linyue Wang, Zhixia Mu, Xingke Fu, Xia Yu, Bo Qin, Hongtao Zhu, Wei Ding, Sheng Cui

Journal: Nature

Doi: doi.org/10.1038/s41586-023-06665-6

Products & Services: Gene Synthesis

A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of to metal restriction

Authors: Joy R Paterson, Joshua M Wadsworth, Ping Hu, Gary J Sharples

Journal: Microb Genom

PubMed ID: 38054971

Doi: 10.1099/mgen.0.001153

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A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels

Authors: Jian Zhou, Claudia Cattoglio, Yingyao Shao, Harini P Tirumala, Carlo Vetralla, Sameer S Bajikar, Yan Li, Hu Chen, Qi Wang, Zhenyu Wu, Bing Tang, Mahla Zahabiyon, Aleksandar Bajic, Xiangling Meng, Jack J Ferrie, Anel LaGrone, Ping Zhang, Jean J Kim, Jianrong Tang, Zhandong Liu, Xavier Darzacq, Nathaniel Heintz, Robert Tjian, Huda Y Zoghbi

Journal: Genes Dev

PubMed ID: 37890975

Doi: 10.1101/gad.350733.123

Products & Services: Protein and Antibody Isolation

Overexpressing CsPSY1 Gene of Tea Plant, Encoding a Phytoene Synthase, Improves α-Carotene and β-Carotene Contents in Carrot

Authors: Jing-Wen Li, Ping Zhou, Yuan-Jie Deng, Zhi-Hang Hu, Xing-Hui Li, Xuan Chen, Ai-Sheng Xiong, Jing Zhuang

Journal: Mol Biotechnol

PubMed ID: 37897587

Doi: 10.1007/s12033-023-00942-5

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Rational Design of Taxadiene Hydroxylase by Ancestral Enzyme Construction and the Elucidation of Key Amino Acids

Authors: Zihan Zhang, Longhao Huang, Zhi-Jun Zhang, Jian-He Xu, Hui-Lei Yu

Journal: Biochemistry

PubMed ID: 37902563

Doi: 10.1021/acs.biochem.3c00411

Products & Services: Protein and Antibody Isolation

Single Amino Acid Mutation Decouples Photochemistry of the BLUF Domain from the Enzymatic Function of OaPAC and Drives the Enzyme to a Switched-on State

Authors: Jinnette Tolentino Collado, Emoke Bodis, Jonatan Pasitka, Mihaly Szucs, Zsuzsanna Fekete, Nikolett Kis-Bicskei, Elek Telek, Kinga Pozsonyi, Sofia M Kapetanaki, Greg Greetham, Peter J Tonge, Stephen R Meech, Andras Lukacs

Journal: J Mol Biol

PubMed ID: 37827329

Doi: 10.1016/j.jmb.2023.168312

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FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design

Authors: Wern Hann Ng, Xiang Liu, Zheng L Ling, Camilla N O Santos, Lucas S Magalhães, Andrew J Kueh, Marco J Herold, Adam Taylor, Joseph R Freitas, Sandra Koit, Sainan Wang, Andrew R Lloyd, Mauro M Teixeira, Andres Merits, Roque P Almeida, Nicholas J C King, Suresh Mahalingam

Journal: Nat Commun

PubMed ID: 37884534

Doi: 10.1038/s41467-023-42330-2

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Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence

Authors: Sunita Gulati, Andreas Holm Mattsson, Sophie Schussek, Bo Zheng, Rosane B DeOliveira, Jutamas Shaughnessy, Lisa A Lewis, Peter A Rice, Pär Comstedt, Sanjay Ram

Journal: MBio

PubMed ID: 37905891

Doi: 10.1128/mbio.02500-23

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Biochemical and biophysical properties of a rare TTRA81V mutation causing mild transthyretin amyloid cardiomyopathy

Authors: Qiuyan Sha, Yanli Zhang, Mengdie Wang, Jialu Sun, Yunlong Zhang, Xinxin Zhang, Ning Wang, Yu Liu, Ying Liu

Journal: ESC Heart Fail

PubMed ID: 37827496

Doi: 10.1002/ehf2.14543

Products & Services: Protein and Antibody Isolation

ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1

Authors: Karin Enell Smith, Sara Fritzell, Anneli Nilsson, Karin Barchan, Anna Rosén, Lena Schultz, Laura Varas, Anna Säll, Nadia Rose, Maria Håkansson, Laura von Schantz, Peter Ellmark

Journal: Cancer Immunol Immunother

PubMed ID: 37796298

Doi: 10.1007/s00262-023-03548-7

Products & Services: Gene Synthesis

Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer

Authors: Giuditta Guerrini, Dora Mehn, Francesco Fumagalli, Sabrina Gioria, Mattia Pedotti, Luca Simonelli, Filippo Bianchini, Davide F Robbiani, Luca Varani, Luigi Calzolai

Journal: Int J Mol Sci

PubMed ID: 37834322

Doi: 10.3390/ijms241914875

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Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics

Authors: Katarzyna Pustelny, Przemyslaw Grygier, Agata Barzowska, Barbara Pucelik, Alex Matsuda, Krzysztof Mrowiec, Emilia Slugocka, Grzegorz M Popowicz, Grzegorz Dubin, Anna Czarna

Journal: Sci Rep

PubMed ID: 37872245

Doi: 10.1038/s41598-023-44810-3

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Industry updates from the field of stem cell research and regenerative medicine in August 2023

Authors: Dusko Ilic, Mirjana Liovic

Journal: Regen Med

PubMed ID: 37786963

Doi: 10.2217/rme-2023-0181

Products & Services: Protein and Antibody Isolation

Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Authors: Payton A-B Weidenbacher, Mrinmoy Sanyal, Natalia Friedland, Shaogeng Tang, Prabhu S Arunachalam, Mengyun Hu, Ozan S Kumru, Mary Kate Morris, Jane Fontenot, Lisa Shirreff, Jonathan Do, Ya-Chen Cheng, Gayathri Vasudevan, Mark B Feinberg, Francois J Villinger, Carl Hanson, Sangeeta B Joshi, David B Volkin, Bali Pulendran, Peter S Kim

Journal: Nat Commun

PubMed ID: 37798288

Doi: 10.1038/s41467-023-42061-4

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Nucleic acid-triggered NADase activation of a short prokaryotic Argonaute

Authors: Xiaopan Gao , Kun Shang , Kaixiang Zhu , Linyue Wang , Zhixia Mu , Xingke Fu , Xia Yu , Bo Qin , Hongtao Zhu , Wei Ding , Sheng Cui

Journal: Nature .

PubMed ID: 37783228

Doi: 10.1038/s41586-023-06665-6

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Molecular basis of methyl-salicylate-mediated plant airborne defence

Authors: Qian Gong , Yunjing Wang , Linfang He , Fan Huang , Danfeng Zhang , Yan Wang , Xiang Wei , Meng Han , Haiteng Deng , Lan Luo , Feng Cui , Yiguo Hong, Yule Liu

Journal: Nature .

PubMed ID: 37704724

Doi: 10.1038/s41586-023-06533-3

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Plant-Based Meat Analogues Weaken Gastrointestinal Digestive Function and Show Less Digestibility Than Real Meat in Mice

Authors: Yunting Xie , Linlin Cai , Zhiji Huang , Kai Shan , Xinglian Xu , Guanghong Zhou , Chunbao Li

Journal: J Agric Food Chem .

PubMed ID: 36070521

Doi: 10.1021/acs.jafc.2c04246

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Examining the Potential Formation of Ternary DNA Complexes with Chromium‑Cysteine, Chromium-Ascorbate, and Chromium-Glutathione and Implications for Their Carcinogenicity

Authors: Sydney Marchi , Emma Lankford , Bradley Dorin , Eilidh Drummond , Sumner C Thomas , Stephen A Woski , John B Vincent

Journal: Biol Trace Elem Res .

PubMed ID: 36662348

Doi: 10.1007/s12011-023-03573-8

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Are Histidine Kinases of Arbuscular Mycorrhizal Fungi Involved in the Response to Ethylene and Cytokinins?

Authors: Ayla Mongès, Hajar Yaakoub, Baptiste Bidon, Gaëlle Glévarec, François Héricourt, Sabine Carpin, Lucie Chauderon, Lenka Drašarová, Lukáš Spíchal, Brad M Binder, Nicolas Papon, Soizic Rochange

Journal: Mol Plant Microbe Interact .

PubMed ID: 37851914

Doi: 10.1094/MPMI-05-23-0056-R

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LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway

Authors: Kai-Jie He, Jin-Bao Zhang, Jun-Yi Liu, Feng-Lun Zhao, Xiao-Yu Yao, Yu-Ting Tang, Jin-Ru Zhang, Xiao-Yu Cheng, Li-Fang Hu, Fen Wang, Chun-Feng Liu

Journal: iScience

PubMed ID: 37876795

Doi: 10.1016/j.isci.2023.108130

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β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

Authors: Carole Daly, Akim Abdul Guseinov, Hyunggu Hahn, Adam Wright, Irina G Tikhonova, Alex Rojas Bie Thomsen, Bianca Plouffe

Journal: Elife

PubMed ID: 37855711

Doi: 10.7554/eLife.87754

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Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion

Authors: James S Foster, Manasi Balachandran, Trevor J Hancock, Emily B Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D Williams, Joseph W Jackson, Stephen J Kennel, Jonathan S Wall

Journal: Front Immunol

PubMed ID: 37854603

Doi: 10.3389/fimmu.2023.1275372

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Whole-genome sequence and mass spectrometry study of the snow blight fungus Phacidium infestans (Karsten) DSM 5139 growing at freezing temperatures

Authors: C Zerouki, K Chakraborty, S Kuittinen, A Pappinen, O Turunen

Journal: Mol Genet Genomics

PubMed ID: 37815644

Doi: 10.1007/s00438-023-02073-7

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Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2

Authors: Rodrigo Lázaro-Gorines, Patricia Pérez, Ignacio Heras-Murillo, Irene Adán-Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L Harwood, Alejandro Segura-Tudela, Laura Rubio-Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A Adipietro, Dinendra L Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D MacKerell, Laura Sanz, David J Weber, Francisco J Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy-Ruiz, Inés G Muñoz, Rafael Delgado, David Sancho, Juan García-Arriaza, Luis Álvarez-Vallina

Journal: Adv Sci (Weinh)

PubMed ID: 37863812

Doi: 10.1002/advs.202304818

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Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina

Authors: Heonuk Jeong, Deokho Lee, Xiaoyan Jiang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara

Journal: Sci Rep

PubMed ID: 37857760

Doi: 10.1038/s41598-023-44983-x

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Selection, activity, and nuclease stabilization of cross-neutralizing DNA aptamers targeting HSV-1 and HSV-2

Authors: Michael D Schump, David I Bernstein, Fernando J Bravo, Charles P Neff

Journal: Virology

PubMed ID: 37925791

Doi: 10.1016/j.virol.2023.109916

Products & Services: Molecular Biology Reagents

Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease

Authors: Takashi Kei Kishimoto, Max Fournier, Alicia Michaud, Gina Rizzo, Christopher Roy, Teresa Capela, Natasha Nukolova, Ning Li, Liam Doyle, Fen-Ni Fu, Derek VanDyke, Peter G Traber, Jamie B Spangler, Sheldon S Leung, Petr O Ilyinskii

Journal: J Autoimmun

PubMed ID: 37844543

Doi: 10.1016/j.jaut.2023.103125

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Aptabinding of tumor necrosis factor-α (TNFα) inhibits its proinflammatory effects and alleviates islet inflammation

Authors: Roaa Mahmoud, Jagan Kalivarathan, Abdul J Castillo, Sasha Wang, Brian Fuglestad, Mazhar A Kanak, Soma Dhakal

Journal: Biotechnol J

PubMed ID: 37772688

Doi: 10.1002/biot.202300374

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GhL1L1 regulates the contents of unsaturated fatty acids by activating the expression of GhFAD2 genes in cotton

Authors: Dandan Yue, Xuyang Hao, Bei Han, Jiao Xu, Weinan Sun, Xiaoping Guo, Xianlong Zhang, Xiyan Yang

Journal: Gene

PubMed ID: 37839764

Doi: 10.1016/j.gene.2023.147899

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A circRNA therapy based on Rnf103 to inhibit Vibrio anguillarum infection

Authors: Weiwei Zheng, Xing Lv, Yaqi Tao, Yanqiu Cui, Xiangxiang Zhu, Tongtong Zhu, Tianjun Xu

Journal: Cell Rep

PubMed ID: 37874674

Doi: 10.1016/j.celrep.2023.113314

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Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens

Authors: Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma

Journal: Poult Sci

PubMed ID: 37984004

Doi: 10.1016/j.psj.2023.103251

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A newly identified ferritin L-subunit variant results in increased proteasomal subunit degradation, impaired complex assembly, and severe hypoferritinemia

Authors: Dayana Shagidov, Noga Guttmann-Raviv, Séverine Cunat, Liora Frech, Muriel Giansily-Blaizot, Niraj Ghatpande, Gili Abelya, Gabriel A Frank, Patricia Aguilar Martinez, Esther G Meyron-Holtz

Journal: Am J Hematol

PubMed ID: 37867341

Doi: 10.1002/ajh.27124

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Characterization of a thermostable Cas12a ortholog

Authors: Jing Wu, Pan Gao, Yajing Shi, Caixiang Zhang, Xiaohan Tong, Huidi Fan, Xi Zhou, Ying Zhang, Hao Yin

Journal: Cell Insight

PubMed ID: 38047138

Doi: 10.1016/j.cellin.2023.100126

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Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution

Authors: Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, Stefania Brocca

Journal: Int J Biol Macromol

PubMed ID: 38287572

Doi: 10.1016/j.ijbiomac.2023.127754

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Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time- Resolved Monitoring of Substrate Ubiquitination in Live Cells

Authors: Lu-Jun Liang, Yu Wang, Xiao Hua, Rujing Yuan, Qiong Xia, Rongtian Wang, Chuntong Li, Guo-Chao Chu, Lei Liu, and Yi-Ming Li

Journal: JACS Au

Doi: 10.1021/jacsau.3c00421

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A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering

Authors: Zhiheng Yang , Zilong Li , Bixiao Li , Ruihong Bu , Gao-Yi Tan , Zhengduo Wang , Hao Yan , Zhenguo Xin , Guojian Zhang , Ming Li , Hua Xiang, Lixin Zhang , Weishan Wang

Journal: Nat Commun .

PubMed ID: 37794017

Doi: 10.1038/s41467-023-41973-5

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A 3D-printed blood-brain barrier model with tunable topology and cell-matrix interactions

Authors: Louis S Paone , Mohammed Mehdi Benmassaoud , Aidan Curran , Sebastián L Vega , Peter A Galie

Journal: Biofabrication .

PubMed ID: 37820611

Doi: 10.1088/1758-5090/ad0260

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Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis

Authors: Alžběta Motyčková, Luboš Voleman, Vladimíra Najdrová, Lenka Arbonová, Martin Benda, Vít Dohnálek, Natalia Janowicz, Ronald Malych, Róbert Šuťák, Thijs J G Ettema, Staffan Svärd, Courtney W Stairs, Pavel Doležal

Journal: PLoS Pathog

PubMed ID: 37792908

Doi: 10.1371/journal.ppat.1010773

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The Functional Characteristics and Soluble Expression of Saffron CCD2

Authors: Ying Wang, Siqi Li, Ze Zhou, Lifen Sun, Jing Sun, Chuanpu Shen, Ranran Gao, Jingyuan Song, Xiangdong Pu

Journal: Int J Mol Sci

PubMed ID: 37894770

Doi: 10.3390/ijms242015090

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Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes

Authors: Madeeha Ghazi, Shivangi Khanna, Yogaspoorthi Subramaniam, Jeyashri Rengaraju, Farina Sultan, Iti Gupta, Kanupriya Sharma, Sudhir Chandna, Rajesh S Gokhale, Vivek T Natarajan

Journal: Nucleic Acids Res

PubMed ID: 37697436

Doi: 10.1093/nar/gkad704

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A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

Authors: Lounis Yakhou, Anaelle Azogui, Nikhil Gupta, Julien Richard Albert, Fumihito Miura, Laure Ferry, Kosuke Yamaguchi, Sarah Battault, Pierre Therizols, Frédéric Bonhomme, Elouan Bethuel, Arpita Sarkar, Maxim V C Greenberg, Paola B Arimondo, Gael Cristofari, Olivier Kirsh, Takashi Ito, Pierre-Antoine Defossez

Journal: Nucleic Acids Res

PubMed ID: 37650637

Doi: 10.1093/nar/gkad719

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Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells

Authors: Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim

Journal: Nature

PubMed ID: 37880368

Doi: 10.1038/s41586-023-06676-3

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A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells

Authors: Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, Haiming Huang

Journal: Front Immunol

PubMed ID: 37954614

Doi: 10.3389/fimmu.2023.1292839

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Dual immunization with CdtB protein and flagellin epitope offers augmented protection against enteric fever in mice

Authors: Shania Vij, Reena Thakur, Raghwendra Pratap Singh, Rashmi Kumar, Preeti Pathania, Varsha Gupta, Chander Raman Suri, Praveen Rishi