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Loss of ATG4B and ATG4A results in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells

Authors: Paalini Sathiyaseelan, Suganthi Chittaranjan, Steve E Kalloger, Jennifer Chan, Nancy E Go, Mario A Jardon, Cally J Ho, Theodore Hui, Jing Xu, Christine Chow, Dongxia Gao, Fraser D Johnson, William W Lockwood, Gregg B Morin, Daniel J Renouf, David F Schaeffer, Sharon M Gorski

Journal: J Cell Sci

PubMed ID: 37701987

Doi: 10.1242/jcs.260644

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T cells Use Focal Adhesions to Pull Themselves Through Confined Environments

Authors: Alexia Caillier, David Oleksyn, Deborah J Fowell, Jim Miller, Patrick W Oakes

Journal: biorxiv

PubMed ID: 37904911

Doi: 10.1101/2023.10.16.562587

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The Exocyst Subunit CsExo70B Promotes Both Fruit Length and Disease Resistance via Regulating Receptor Kinase Abundance at Plasma Membrane in Cucumber

Authors: Liu Liu , Jiacai Chen , Chaoheng Gu , Shaoyun Wang , Yufan Xue , Zhongyi Wang , Lijie Han , Weiyuan Song , Xiaofeng Liu , Jiahao Zhang , Min Li , Chuang Li , Liming Wang , Xiaolan Zhang , Zhaoyang Zhou

Journal: Plant Biotechnol J .

PubMed ID: 37795910

Doi: 10.1111/pbi.14189

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A Small RNA, SaaS, Promotes Salmonella Pathogenicity by Regulating Invasion, Intracellular Growth, and Virulence Factors

Authors: Lin-Lin Cai, Yun-Ting Xie , Hai-Jing Hu , Xing-Lian Xu , Hu-Hu Wang , Guang-Hong Zhou

Journal: Microbiol Spectr .

PubMed ID: 36688642

Doi: 10.1128/spectrum.02938-22

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Structure and function analysis of a type III preQ1-I riboswitch from Escherichia coli reveals direct metabolite sensing by the Shine-Dalgarno sequence

Authors: Griffin M Schroeder , Daniil Kiliushik , Jermaine L Jenkins , Joseph E Wedekind

Journal: J Biol Chem .

PubMed ID: 37660906

Doi: 10.1016/j.jbc.2023.105208

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Rules and mechanisms governing G protein coupling selectivity of GPCRs

Authors: Ikuo Masuho , Ryoji Kise , Pablo Gainza , Ee Von Moo , Xiaona Li , Ryosuke Tany , Hideko Wakasugi-Masuho , Bruno E Correia , Kirill A Martemyanov

Journal: Cell Rep .

PubMed ID: 37742189

Doi: 10.1016/j.celrep.2023.113173

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A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo

Authors: Eirini Giannakopoulou , Madeleine Lehander , Stina Virding Culleton , Weiwen Yang , Yingqian Li , Terhi Karpanen , Tetsuichi Yoshizato , Even H Rustad , Morten Milek Nielsen , Ravi Chand Bollineni , Trung T Tran , Marina Delic-Sarac , Thea Johanne Gjerdingen , Karolos Douvlataniotis , Maarja Laos , Muhammad Ali , Amy Hillen , Stefania Mazzi , Desmond Wai Loon Chin , Adi Mehta , Jeppe Sejerø Holm , Amalie Kai Bentzen , Marie Bill , Marieke Griffioen , Tobias Gedde-Dahl, Sören Lehmann , Sten Eirik W Jacobsen , Petter S Woll , Johanna Olweus

Journal: Nat Cancer .

PubMed ID: 37783807

Doi: 10.1038/s43018-023-00642-8

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Investigation of serum amyloid a within animal species focusing on the 1-25 amino acid region

Authors: Natalie G Horgan, Kendall B E Moore, Jessica S Fortin

Journal: Vet Q

PubMed ID: 37800590

Doi: 10.1080/01652176.2023.2267605

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Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease

Authors: Xingyu Zhang, Li Tang, Jiaolong Yang, Lanxia Meng, Jiehui Chen, Lingyan Zhou, Jiangyu Wang, Min Xiong, Zhentao Zhang

Journal: Nat Commun

PubMed ID: 37865646

Doi: 10.1038/s41467-023-42505-x

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Recovery of protein synthesis to assay DNA repair activity in transcribed genes in living cells and tissues

Authors: Melanie van der Woude, Carlota Davó-Martínez, Karen L Thijssen, Wim Vermeulen, Hannes Lans

Journal: Nucleic Acids Res

PubMed ID: 37522336

Doi: 10.1093/nar/gkad642

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A novel C-type lectin (SpccCTL) suppresses MCRV replication by binding viral protein and regulating antiviral peptides in Scylla paramamosain

Authors: Qing-Feng Yang, Shouhu Li, Guang-Peng Feng, Chuang Qin, Xiu-Wen Min, Wen-Hong Fang, Yue Wu, Jin Zhou, Xin-Cang Li

Journal: Fish Shellfish Immunol

PubMed ID: 37827249

Doi: 10.1016/j.fsi.2023.109143

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Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form

Authors: Tyler B Alt, Matthew R Hoag, Graham R Moran

Journal: Arch Biochem Biophys

PubMed ID: 37820757

Doi: 10.1016/j.abb.2023.109772

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Cornelia de Lange Syndrome mutations in SMC1A cause cohesion defects in yeast

Authors: Jingrong Chen, Erin N Floyd, Dean S Dawson, Susannah Rankin

Journal: Genetics

PubMed ID: 37650609

Doi: 10.1093/genetics/iyad159

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Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies

Authors: Matthias Schmidt, Namil Lee, Chunjun Zhan, Jacob B Roberts, Alberto A Nava, Leah S Keiser, Aaron A Vilchez, Yan Chen, Christopher J Petzold, Robert W Haushalter, Lars M Blank, Jay D Keasling

Journal: ACS Synth Biol

PubMed ID: 37851920

Doi: 10.1021/acssynbio.3c00367

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CRISPR/Cas9 System-Mediated Multi-copy Expression of an Alkaline Serine Protease in for the Production of XOD-Inhibitory Peptides

Authors: Shounan Wang, Yibin Xue, Peng Zhang, Qiaojuan Yan, Yanxiao Li, Zhengqiang Jiang

Journal: J Agric Food Chem

PubMed ID: 37807677

Doi: 10.1021/acs.jafc.3c04138

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SARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition

Authors: Rachel Erickson, Chang Huang, Cameron Allen, Joanna Ireland, Gwynne Roth, Zhongcheng Zou, Jinghua Lu, Bernard A P Lafont, Nicole L Garza, Beniah Brumbaugh, Ming Zhao, Motoshi Suzuki, Lisa Olano, Joseph Brzostowski, Elizabeth R Fischer, Homer L Twigg, Reed F Johnson, Peter D Sun

Journal: Nat Commun

PubMed ID: 37821447

Doi: 10.1038/s41467-023-42140-6

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Specific Nucleotides in the Common Region of the Begomovirus Tomato Rugose Mosaic Virus (ToRMV) Are Responsible for the Negative Interference over Tomato Severe Rugose Virus (ToSRV) in Mixed Infection

Authors: Angélica M Nogueira, Tarsiane M C Barbosa, Ayane F F Quadros, Anelise F Orílio, Marcela C J Bigão, César A D Xavier, Camila G Ferro, Francisco Murilo Zerbini

Journal: Viruses

PubMed ID: 37896851

Doi: 10.3390/v15102074

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Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs

Authors: Ghasidit Pornnoppadol, Layne G Bond, Michael J Lucas, Jennifer M Zupancic, Yun-Huai Kuo, Boya Zhang, Colin F Greineder, Peter M Tessier

Journal: Cell Chem Biol

PubMed ID: 37890480

Doi: 10.1016/j.chembiol.2023.09.008

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Lactate promotes intracellular replication and systemic infection via driving macrophage M2 polarization

Authors: Xinyue Wang, Bin Yang, Shuangshuang Ma, Xiaolin Yan, Shuai Ma, Hongmin Sun, Yuyang Sun, Lingyan Jiang

Journal: Microbiol Spectr

PubMed ID: 37796020

Doi: 10.1128/spectrum.02253-23

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Evaluation of potential targets to enhance the sensitivity of cholangiocarcinoma cells to anticancer drugs

Authors: Paula Sanchon-Sanchez, Oscar Briz, Rocio I R Macias, Mar Abad, Anabel Sanchez-Martin, Jose J G Marin, Elisa Lozano

Journal: Biomed Pharmacother

PubMed ID: 37832404

Doi: 10.1016/j.biopha.2023.115658

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Modulating biofilm can potentiate activity of novel plastic-degrading enzymes

Authors: Sophie A Howard, Ronan R McCarthy

Journal: NPJ Biofilms Microbiomes

PubMed ID: 37788986

Doi: 10.1038/s41522-023-00440-1

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Differential regulation of fibronectin expression and fibrillogenesis by autocrine TGF-β1 signaling in malignant and benign mammary epithelial cells

Authors: Michael M Sofroniou, Christopher A Lemmon

Journal: Int J Biochem Cell Biol

PubMed ID: 37866655

Doi: 10.1016/j.biocel.2023.106478

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Development of CRISPR/Cas9-Based Genome Editing Tools for Polyploid Yeast Cyberlindnera jadinii and Its Application in Engineering Heterologous Steroid-Producing Strains

Authors: Lishan Gu, Rongxin Zhang, Xuqian Fan, Yu Wang, Kaiyu Ma, Jingjing Jiang, Gen Li, Honglei Wang, Feiyu Fan, Xueli Zhang

Journal: ACS Synth Biol

PubMed ID: 37816156

Doi: 10.1021/acssynbio.3c00278

Products & Services: Codon Optimization

Identification and production of novel potential pathogen-specific biomarkers for diagnosis of histoplasmosis

Authors: Juan David Puerta-Arias, Juan Pablo Isaza Agudelo, Tonny Williams Naranjo Preciado

Journal: Microbiol Spectr

PubMed ID: 37882565

Doi: 10.1128/spectrum.00939-23

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Antibodies elicited by Plasmodium falciparum circumsporozoite proteins lacking sequentially deleted C-terminal amino acids reveal mouse strain and epitopes specific differences

Authors: Clifford T H Hayashi, Yi Cao, Fidel Zavala, Hayk Simonyan, Colin N Young, Nirbhay Kumar

Journal: Vaccine

PubMed ID: 37827976

Doi: 10.1016/j.vaccine.2023.10.009

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Structural and functional characterization of Aedes aegypti pupal cuticle protein that controls dengue virus infection

Authors: Qingqing Huang, Edem Gavor, Nikhil Kumar Tulsian, Jingsong Fan, Qingsong Lin, Yu Keung Mok, R Manjunatha Kini, J Sivaraman

Journal: Protein Sci

PubMed ID: 37593853

Doi: 10.1002/pro.4761

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DETECTION OF SARS-COV-2 NEUTRALIZING ANTIBODIES IN RETROPHARYNGEAL LYMPH NODE EXUDATES OF WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) FROM NEBRASKA, USA

Authors: Korakrit Poonsuk, Duan Loy, Rachael Birn, Bryan Buss, Matthew Donahue, Todd Nordeen, Kylie Sinclair, Luke Meduna, Bruce Brodersen, John Dustin Loy

Journal: J Wildl Dis

PubMed ID: 37768779

Doi: 10.7589/JWD-D-23-00005

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MpADC, an L-aspartate-α-decarboxylase, from Myzus persicae, that enables production of β-alanine with high yield by whole-cell enzymatic catalysis

Authors: Pengfu Liu, Saixue Xie, Qian Guo, Yan Chen, Junying Fan, Ashok Kumar Nadda, Xiaoluo Huang, Xiaohe Chu

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 37876019

Doi: 10.1186/s13068-023-02405-0

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Author Correction: Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses

Authors: Xiuyuan Ou, Ge Xu, Pei Li, Yan Liu, Fuwen Zan, Pan Liu, Jiaxin Hu, Xing Lu, Siwen Dong, Yao Zhou, Zhixia Mu, Zhiqiang Wu, Jianwei Wang, Qi Jin, Pinghuang Liu, Jian Lu, Xiangxi Wang, Zhaohui Qian

Journal: Cell Discov

PubMed ID: 37813850

Doi: 10.1038/s41421-023-00597-1

Products & Services: Protein and Antibody Isolation

G-quadruplexes of KSHV oriLyt play important roles in promoting lytic DNA replication

Authors: Prerna Dabral, Timsy Uppal, Subhash C Verma

Journal: Microbiol Spectr

PubMed ID: 37800915

Doi: 10.1128/spectrum.05316-22

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Intradermal DNA vaccine delivery using vacuum-controlled, needle-free electroporation

Authors: Alison Generotti, Ryne Contreras, Brenden Zounes, Eric Schade, Andrea Kemme, Yatish Rane, Xinggang Liu, Dustin Elwood, Katherine Schultheis, Jeremy Marston, Jay McCoy, Kate Broderick, Paul Fisher

Journal: Mol Ther Nucleic Acids

PubMed ID: 38034030

Doi: 10.1016/j.omtn.2023.102070

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Expression of a SAG protein with a CAP domain from Eimeria necatrix and its role in invasion and immunoprotection

Authors: Feiyan Wang, Amin Zhang, Xuelian Fan, Qianqian Feng, Zhizhi Zhang, Dandan Liu, Shijie Su, Zhaofeng Hou, Jinjun Xu, Xilong Kang, Zhiming Pan, Hunjie Hu, Jianping Tao

Journal: Vet Parasitol

PubMed ID: 37931477

Doi: 10.1016/j.vetpar.2023.110060

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A two-arm analysis of the immune response to heterologous boosting of inactivated SARS-CoV-2 vaccines

Authors: Arnone Nithichanon, Ludthawun Kamuthachad, Kanin Salao, Wisitsak Phoksawat, Chatcharin Kamsom, Surasakdi Wongratanacheewin, Chonlatip Pipattanaboon, Sakawrat Kanthawong, Umaporn Yordpratum, Sirinart Aromseree, Atibordee Meesing, Piroon Mootsikapun, Steven W Edwards, Supranee Phanthanawiboon

Journal: Sci Rep

PubMed ID: 37907584

Doi: 10.1038/s41598-023-46053-8

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Tetravalent SARS-CoV-2 S1 subunit protein vaccination elicits robust humoral and cellular immune responses in SIV-infected rhesus macaque controllers

Authors: Muhammad S Khan, Eun Kim, Quentin Le Hingrat, Adam Kleinman, Alessandro Ferrari, Jose C Sammartino, Elena Percivalle, Cuiling Xu, Shaohua Huang, Thomas W Kenniston, Irene Cassaniti, Fausto Baldanti, Ivona Pandrea, Andrea Gambotto, Cristian Apetrei

Journal: MBio

PubMed ID: 37830800

Doi: 10.1128/mbio.02070-23

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Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes

Authors: Wei-Xin Chin, Hao Yuin Kong, Isabelle Xin Yu Zhu, Zi Yun Teo, Regina Faruk, Regina Ching Hua Lee, Si Xian Ho, Zhen Qin Aw, Bowen Yi, Xin Jun Hou, Antson Kiat Yee Tan, Thinesshwary Yogarajah, Roland G Huber, Yu Cai, Yue Wan, Justin Jang Hann Chu

Journal: PLoS Pathog

PubMed ID: 37883598

Doi: 10.1371/journal.ppat.1011753

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Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

Authors: Ryan D Mouery, Carolyn Hsu, Thomas Bonacci, Derek L Bolhuis, Xianxi Wang, Christine A Mills, E Drew Toomer, Owen G Canterbury, Kevin C Robertson, Timothy B Branigan, Nicholas G Brown, Laura E Herring, Michael J Emanuele

Journal: biorxiv

PubMed ID: 37873169

Doi: 10.1101/2023.10.11.561963

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Improved Stability and Manufacturability of Nucleocapsid Antigens for SARS-CoV2 Diagnostics through Protein Engineering

Authors: Esha Shukla, Lipsa Choudhury, Saurabh Rastogi, Arshmeet Chawla, Sanghati Bhattacharya, Umesh Kaushik, Manan Mittal, Anurag Singh Rathore, Gaurav Pandey

Journal: Biomolecules

PubMed ID: 37892206

Doi: 10.3390/biom13101524

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Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis‑induced cardiomyopathy

Authors: Xin Lin, Xiaoxia Zhao, Qingfeng Chen, Xiaoyue Wang, Yongya Wu, Hao Zhao

Journal: Int J Mol Med

PubMed ID: 37859612

Doi: 10.3892/ijmm.2023.5319

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The cell-end protein Tea4 spatially regulates hyphal branch initiation and appressorium remodeling in the blast fungus

Authors: Audra Mae Rogers, Rachel Taylor, Martin John Egan

Journal: Mol Biol Cell

PubMed ID: 37903237

Doi: 10.1091/mbc.E23-06-0214

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Cryo-EM structure of severe fever with thrombocytopenia syndrome virus

Authors: Shouwen Du, Ruchao Peng, Wang Xu, Xiaoyun Qu, Yuhang Wang, Jiamin Wang, Letian Li, Mingyao Tian, Yudong Guan, Jigang Wang, Guoqing Wang, Hao Li, Lingcong Deng, Xiaoshuang Shi, Yidan Ma, Fengting Liu, Minhua Sun, Zhengkai Wei, Ningyi Jin, Wei Liu, Jianxun Qi, Quan Liu, Ming Liao, Chang Li

Journal: Nat Commun

PubMed ID: 37816705

Doi: 10.1038/s41467-023-41804-7

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Evaluation and comparison of immune responses induced by two Mpox mRNA vaccine candidates in mice

Authors: Xidan Yang , Congxia Hu , Xuetao Yang , Xiu Yang , Xing Hu , Xingyun Wang , Cong Liu, Yuan Yuan , Shouwen Du , Peng George Wang, Jihui Lin

Journal: J Med Virol .

PubMed ID: 37800627

Doi: 10.1002/jmv.29140

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Horizontally transferred salivary protein promotes insect feeding by suppressing ferredoxin-mediated plant defenses

Authors: Yi-Zhe Wang , Yu-Xuan Ye , Jia-Bao Lu , Xin Wang , Hai-Bin Lu , Ze-Long Zhang , Zhuang-Xin Ye , Yu-Wen Lu , Zong-Tao Sun , Jian-Ping Chen , Jun-Min Li , Chuan-Xi Zhang , Hai-Jian Huang

Journal: Mol Biol Evol .

PubMed ID: 37804524

Doi: 10.1093/molbev/msad221

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Rapid characterization of anti-CRISPR proteins and optogenetically engineered variants using a versatile plasmid interference system

Authors: Guoxu Song, Chunhong Tian, Jiahui Li, Fei Zhang, Yuxin Peng, Xing Gao and Yong Tian

Journal: Nucleic Acids Research

Doi: 10.1093/nar/gkad995

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Establishment and characterization of a novel indirect ELISA method based on ASFV antigenic epitope-associated recombinant protein

Authors: Jiaxin Jin , Yilin Bai , Yuanyuan Zhang , Wenlong Lu , Shuai Zhang , Xuyang Zhao , Yaning Sun , Yanan Wu , Angke Zhang , Gaiping Zhang , Aijun Sun , Guoqing Zhuang

Journal: Int J Biol Macromol .

PubMed ID: 37865977

Doi: 10.1016/j.ijbiomac.2023.127311

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Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes

Authors: Alexandra Unapanta , Farbod Shavarebi , Jacob Porath , Yiyi Shen , Carson Balen , Albert Nguyen , Josh Tseng , Weng Si Leong , Michelle Liu , Pawel Lis , Santiago M Di Pietro , Annie Hiniker

Journal: J Biol Chem .

PubMed ID: 37625589

Doi: 10.1016/j.jbc.2023.105192

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Chemoproteomic capture of RNA binding activity in living cells

Authors: Andrew J Heindel, Jeffrey W Brulet, Xiantao Wang, Michael W Founds, Adam H Libby, Dina L Bai, Michael C Lemke, David M Leace, Thurl E Harris, Markus Hafner, Ku-Lung Hsu

Journal: Nat Commun

PubMed ID: 37805600

Doi: 10.1038/s41467-023-41844-z

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Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura

Authors: Zhitao Wang, Xinhui Zhang, Xueqin Lu, Peng Peng, Huiru Wang, Shanglong Feng, Li Zhou

Journal: Hematology

PubMed ID: 37850618

Doi: 10.1080/16078454.2023.2269513

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Authentication of a lophotrochozoan adipokinetic hormone receptor in a Gastropod, Aplysia californica

Authors: Pei-San Tsai, Kelsey N Sanders, Xin Dai, David Plachetzki

Journal: Gen Comp Endocrinol

PubMed ID: 37865149

Doi: 10.1016/j.ygcen.2023.114393

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Investigation of Immunostimulatory Effects of IFN-γ Cytokine and CD40 Ligand Costimulatory Molecule for Development of HIV-1 Therapeutic Vaccine Candidate

Authors: Fatemeh Heidarnejad, Azam Bolhassani, Soheila Ajdary, Alireza Milani, Seyed Amir Sadeghi

Journal: Adv Biol (Weinh)

PubMed ID: 37840398

Doi: 10.1002/adbi.202300402

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Folic acid alleviated oxidative stress-induced telomere attrition and inhibited apoptosis of neurocytes in old rats

Authors: Dezheng Zhou, Yue Sun, Cuixia Dong, Zehao Wang, Jing Zhao, Zhenshu Li, Guowei Huang, Wen Li

Journal: Eur J Nutr

PubMed ID: 37870657

Doi: 10.1007/s00394-023-03266-x

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