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Functional characterization of a lytic polysaccharide monooxygenase from Schizophyllum commune that degrades non-crystalline substrates

Authors: Heidi Østby, Idd A Christensen, Karen Hennum, Anikó Várnai, Edith Buchinger, Siri Grandal, Gaston Courtade, Olav A Hegnar, Finn L Aachmann, Vincent G H Eijsink

Journal: Sci Rep

PubMed ID: 37833388

Doi: 10.1038/s41598-023-44278-1

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KRAS G12V neoantigen specific T cell receptor for adoptive T cell therapy against tumors

Authors: Dan Lu, Yuan Chen, Min Jiang, Jie Wang, Yiting Li, Keke Ma, Wenqiao Sun, Xing Zheng, Jianxun Qi, Wenjing Jin, Yu Chen, Yan Chai, Catherine W H Zhang, Hao Liang, Shuguang Tan, George F Gao

Journal: Nat Commun

PubMed ID: 37828002

Doi: 10.1038/s41467-023-42010-1

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Serpin-1a and serpin-6 regulate the Toll pathway immune homeostasis by synergistically inhibiting the Spätzle-processing enzyme CLIP2 in silkworm, Bombyx mori

Authors: Huawei Liu, Jiahui Xu, Luoling Wang, Pengchao Guo, Zhangchen Tang, Xiaotong Sun, Xin Tang, Wei Wang, Lingyan Wang, Yang Cao, Qingyou Xia, Ping Zhao

Journal: PLoS Pathog

PubMed ID: 37851691

Doi: 10.1371/journal.ppat.1011740

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CD8 T-cells target the Crimean-Congo haemorrhagic fever virus Gc protein to control the infection in wild-type mice

Authors: Deepashri Rao, Kimberly Meade-White, Shanna Leventhal, Evan Mihalakakos, Aaron Carmody, Heinz Feldmann, David W Hawman

Journal: EBioMedicine

PubMed ID: 37866114

Doi: 10.1016/j.ebiom.2023.104839

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A biotechnological approach for the production of new protein bioplastics

Authors: Francesca De Marchis, Tania Vanzolini, Elisa Maricchiolo, Michele Bellucci, Michele Menotta, Tomas Di Mambro, Annalisa Aluigi, Andrea Zattoni, Barbara Roda, Valentina Marassi, Rita Crinelli, Andrea Pompa

Journal: Biotechnol J

PubMed ID: 37801630

Doi: 10.1002/biot.202300363

Products & Services: Molecular Biology Reagents

generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2

Authors: Dora Buzas, Adrian H Bunzel, Oskar Staufer, Emily J Milodowski, Grace L Edmunds, Joshua C Bufton, Beatriz V Vidana Mateo, Sathish K N Yadav, Kapil Gupta, Charlotte Fletcher, Maia K Williamson, Alexandra Harrison, Ufuk Borucu, Julien Capin, Ore Francis, Georgia Balchin, Sophie Hall, Mirella V Vega, Fabien Durbesson, Srikanth Lingappa, Renaud Vincentelli, Joe Roe, Linda Wooldridge, Rachel Burt, Ross J L Anderson, Adrian J Mulholland, Jonathan Hare, Mick Bailey, Andrew D Davidson, Adam Finn, David Morgan, Jamie Mann, Joachim Spatz, Frederic Garzoni, Christiane Schaffitzel, Imre Berger

Journal: Antib Ther

PubMed ID: 38075238

Doi: 10.1093/abt/tbad024

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Vaccination with post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunity

Authors: Sabaria Shah, Katherine W Cook, Peter Symonds, Juliane Weißer, Anne Skinner, Abdullah Al Omari, Samantha J Paston, Ian Pike, Lindy G Durrant, Victoria A Brentville

Journal: J Immunother Cancer

PubMed ID: 37857526

Doi: 10.1136/jitc-2023-006966

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Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants

Authors: Nidhi Mittal, Sahil Kumar, Raju S Rajmani, Randhir Singh, Céline Lemoine, Virginie Jakob, Sowrabha Bj, Nayana Jagannath, Madhuraj Bhat, Debajyoti Chakraborty, Suman Pandey, Aurélie Jory, Suba Soundarya Sa, Harry Kleanthous, Patrice Dubois, Rajesh P Ringe, Raghavan Varadarajan

Journal: npj Vaccines

PubMed ID: 37880298

Doi: 10.1038/s41541-023-00755-2

Products & Services: Protein and Antibody Isolation

A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity

Authors: Andras Boeszoermenyi, Léa Bernaleau, Xudong Chen, Felix Kartnig, Min Xie, Haobo Zhang, Sensen Zhang, Maeva Delacrétaz, Anna Koren, Ann-Katrin Hopp, Vojtech Dvorak, Stefan Kubicek, Daniel Aletaha, Maojun Yang, Manuele Rebsamen, Leonhard X Heinz, Giulio Superti-Furga

Journal: Nat Commun

PubMed ID: 37863876

Doi: 10.1038/s41467-023-42070-3

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Ceria Nanozyme Coordination with Curcumin for Treatment of Sepsis-induced Cardiac Injury by Inhibiting Ferroptosis and Inflammation

Authors: Chenxiao Jiang, Qianzhi Shi, Jing Yang, Hao Ren, Lu Zhang, Shan Chen, Jiayi Si, Yihai Liu, Dujuan Sha, Biao Xu, Jie Ni

Journal: J Adv Res

PubMed ID: 37871772

Doi: 10.1016/j.jare.2023.10.011

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Biochemical and structural characterization of a glucan synthase GFGLS2 from edible fungus Grifola frondosa to synthesize β-1, 3-glucan

Authors: Yu-Meng Yang, Xin Fu, Feng-Jie Cui, Lei Sun, Xin-Yi Zan, Wen-Jing Sun

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 37904199

Doi: 10.1186/s13068-023-02380-6

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Plant miRNA bol-miR159 Regulates Gut Microbiota Composition in Mice: Evidence of the Crosstalk between Plant miRNAs and Intestinal Microbes

Authors: Qin Xu, Xinshu Qin, Yi Zhang, Ke Xu, Ying Li, Yinglei Li, Bangran Qi, Yan Li, Xingbin Yang, Xingyu Wang

Journal: J Agric Food Chem

PubMed ID: 37862127

Doi: 10.1021/acs.jafc.3c06104

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Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance

Authors: Ana C F Paiva, Ana R Lemos, Philipp Busse, Madalena T Martins, Diana O Silva, Micael C Freitas, Sandra P Santos, Filipe Freire, Evelyne J Barrey, Xavier Manival, Lisa Koetzner, Timo Heinrich, Ansgar Wegener, Ulrich Grädler, Tiago M Bandeiras, Daniel Schwarz, Pedro M F Sousa

Journal: Biosensors (Basel)

PubMed ID: 37887106

Doi: 10.3390/bios13100913

Products & Services: Protein and Antibody Isolation

Collagen Mimetic Peptide with a Coiled Coil Trimerization Domain Forms Fibrils Having -Period-like Structures

Authors: Faizunnahar Dewan, Michele Kirchner, Fadi Masoud, Zainab Sami, Yujia Xu

Journal: Biomacromolecules

PubMed ID: 37788665

Doi: 10.1021/acs.biomac.3c00901

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Pyruvate kinase is post-translationally regulated by sirtuin 2 in Aedes aegypti mosquitoes

Authors: Natthida Petchampai, Jun Isoe, Prashanth Balaraman, Max Oscherwitz, Brendan H Carter, Cecilia G Sánchez, Patricia Y Scaraffia

Journal: Insect Biochem Mol Biol

PubMed ID: 37797713

Doi: 10.1016/j.ibmb.2023.104015

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Influence of expression and purification protocols on Gα biochemical activity: kinetics of plant and mammalian G protein cycles

Authors: Timothy E Gookin, David Chakravorty, Sarah M Assmann

Journal: biorxiv

PubMed ID: 37214830

Doi: 10.1101/2023.05.10.540258

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Distribution and Degradation of Pork Filamin during Postmortem Aging

Authors: Tongyao Du, Chao Ma, Zixu Wang, Yuejing Hao, Wangang Zhang

Journal: J Agric Food Chem

PubMed ID: 37788342

Doi: 10.1021/acs.jafc.3c04208

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Development and characterization of anti-IL-5 monoclonal antibody Fab fragment for blocking IL-5/IL-5Rα binding

Authors: Shijie Li , Shijie Wang , Eric Fordjour , Yaoji Liang , Xuelian Wang , Yonghao Ye , Zhonghu Bai , Yankun Yang , Yongqi Chen

Journal: International Immunopharmacology

Doi: 10.1016/j.intimp.2023.111032

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Nanopore Signatures of Nucleoside Drugs

Authors: Wendong Jia , Yusheng Ouyang , Shanyu Zhang , Xiaoyu Du , Panke Zhang , Shuo Huang

Journal: Nano Lett .

PubMed ID: 37818841

Doi: 10.1021/acs.nanolett.3c02872

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A chlorophyll c synthase widely co-opted by phytoplankton

Authors: Yanyou Jiang , Tianjun Cao , Yuqing Yang , Huan Zhang , Jingyu Zhang , Xiaobo Li

Journal: Science .

PubMed ID: 37797009

Doi: 10.1126/science.adg7921

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HDL mimetics protect Alzheimer’s patients carrying APOE ε4 from SARS-CoV-2 invasion

Authors: Ruodan Xu , Junwei Gao , Can Cao , Mingfei Shi , Yonghui Zhang , Shihao Hong , Shijie Guo , Menglin Chen , Ping Song , Gaoshuang Fu , Jing Li , Tengxiao Liang , Yingchun Miao , Lu Tang , Jinsheng Yang , Ning Li , Mingdong Dong

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102051

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Single-cell chromatin state transitions during epigenetic memory formation

Authors: Taihei Fujimori, Carolina Rios-Martinez, Abby R Thurm, Michaela M Hinks, Benjamin R Doughty, Joydeb Sinha, Derek Le, Antonina Hafner, William J Greenleaf, Alistair N Boettiger, Lacramioara Bintu

Journal: biorxiv

PubMed ID: 37873344

Doi: 10.1101/2023.10.03.560616

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RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis

Authors: Di Liu, Yize Guo, Qin Du, Yuxuan Zhu, Ya Guo

Journal: Exp Cell Res

PubMed ID: 37797799

Doi: 10.1016/j.yexcr.2023.113795

Products & Services: Molecular Biology Reagents

How myosin VI traps its off-state, is activated and dimerizes

Authors: Louise Canon , Carlos Kikuti , Vicente J Planelles-Herrero , Tianming Lin , Franck Mayeux , Helena Sirkia , Young Il Lee , Leila Heidsieck , Léonid Velikovsky , Amandine David , Xiaoyan Liu ， Dihia Moussaoui , Emma Forest , Peter Höök , Karl J Petersen , Tomos E Morgan , Aurélie Di Cicco , Julia Sirés-Campos , Emmanuel Derivery , Daniel Lévy , Cédric Delevoye , H Lee Sweeney , Anne Houdusse

Journal: Nat Commun

PubMed ID: 37872146

Doi: 10.1038/s41467-023-42376-2

Products & Services: PCR Cloning and Subcloning

Benzbromarone Induces Targeted Degradation of HSP47 Protein and Improves Hypertrophic Scar Formation

Authors: Jung Gyu Park, Dong Chul Lim, Jeong Hwan Park, Seoah Park, Jongsoo Mok, Keon Wook Kang, Joonghoon Park

Journal: J Invest Dermatol

PubMed ID: 37838329

Doi: 10.1016/j.jid.2023.09.279

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Inhibition of N-myristoyltransferase activity promotes androgen receptor degradation in prostate cancer

Authors: Omar Awad Alsaidan, Emmanuel Onobun, Chenming Ye, Lei Lou, Zanna Beharry, Zhong-Ru Xie, Iryna Lebedyeva, David Crich, Houjian Cai

Journal: Prostate

PubMed ID: 37905842

Doi: 10.1002/pros.24645

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Molecular mechanism of sex pheromone perception in male Mythimna loreyi revealed by in vitro system

Authors: Yun-Ying Zhang, Teng-Fei Bai, Jin-Meng Guo, Zhi-Qiang Wei, Si-Ruo Liu, Yu He, Jing-Jing Ye, Qi Yan, Jin Zhang, Shuang-Lin Dong

Journal: Pest Manag Sci

PubMed ID: 37779104

Doi: 10.1002/ps.7806

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Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

Authors: Douglas Sammon, Anja Krueger, Marta Busse-Wicher, Rhodri Marc Morgan, Stuart M Haslam, Benjamin Schumann, David C Briggs, Erhard Hohenester

Journal: Nat Commun

PubMed ID: 37828045

Doi: 10.1038/s41467-023-42236-z

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A morpheein equilibrium regulates catalysis in phosphoserine phosphatase SerB2 from Mycobacterium tuberculosis

Authors: Elise Pierson, Florian De Pol, Marianne Fillet, Johan Wouters

Journal: Commun Biol

PubMed ID: 37817000

Doi: 10.1038/s42003-023-05402-z

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Aggregative adherence fimbriae form compact structures as seen by SAXS

Authors: Rie Jønsson, Alexander Björling, Søren Roi Midtgaard, Grethe Vestergaard Jensen, Nicholas Skar-Gislinge, Lise Arleth, Steve Matthews, Karen Angeliki Krogfelt, Håvard Jenssen

Journal: Sci Rep

PubMed ID: 37783694

Doi: 10.1038/s41598-023-42079-0

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Allele-dependent expression and functionality of lipid enzyme PDAT affects diatom carbon storage and growth

Authors: Yufang Pan, Wanting Zhang, Xiaofei Wang, Juliette Jouhet, Eric Maréchal, Jin Liu, Xiao-Qin Xia, Hanhua Hu

Journal: Plant Physiol

PubMed ID: 37930282

Doi: 10.1093/plphys/kiad581

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The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance

Authors: Matthew K McElwee, Thamotharampillai Dileepan, Shawn A Mahmud, Marc K Jenkins

Journal: J Exp Med

PubMed ID: 37831103

Doi: 10.1084/jem.20230209

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Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform

Authors: Alexander Ernst, Indre Piragyte, Ayisha Marwa Mp, Ngoc Dung Le, Denis Grandgirard, Stephen L Leib, Andrew Oates, Nadia Mercader

Journal: Sci Rep

PubMed ID: 37813860

Doi: 10.1038/s41598-023-43911-3

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The Exocyst Subunit CsExo70B Promotes Both Fruit Length and Disease Resistance via Regulating Receptor Kinase Abundance at Plasma Membrane in Cucumber

Authors: Liu Liu , Jiacai Chen , Chaoheng Gu , Shaoyun Wang , Yufan Xue , Zhongyi Wang , Lijie Han , Weiyuan Song , Xiaofeng Liu , Jiahao Zhang , Min Li , Chuang Li , Liming Wang , Xiaolan Zhang , Zhaoyang Zhou

Journal: Plant Biotechnol J .

PubMed ID: 37795910

Doi: 10.1111/pbi.14189

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A Small RNA, SaaS, Promotes Salmonella Pathogenicity by Regulating Invasion, Intracellular Growth, and Virulence Factors

Authors: Lin-Lin Cai, Yun-Ting Xie , Hai-Jing Hu , Xing-Lian Xu , Hu-Hu Wang , Guang-Hong Zhou

Journal: Microbiol Spectr .

PubMed ID: 36688642

Doi: 10.1128/spectrum.02938-22

Products & Services: Protein and Antibody Isolation

Structure and function analysis of a type III preQ1-I riboswitch from Escherichia coli reveals direct metabolite sensing by the Shine-Dalgarno sequence

Authors: Griffin M Schroeder , Daniil Kiliushik , Jermaine L Jenkins , Joseph E Wedekind

Journal: J Biol Chem .

PubMed ID: 37660906

Doi: 10.1016/j.jbc.2023.105208

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Rules and mechanisms governing G protein coupling selectivity of GPCRs

Authors: Ikuo Masuho , Ryoji Kise , Pablo Gainza , Ee Von Moo , Xiaona Li , Ryosuke Tany , Hideko Wakasugi-Masuho , Bruno E Correia , Kirill A Martemyanov

Journal: Cell Rep .

PubMed ID: 37742189

Doi: 10.1016/j.celrep.2023.113173

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A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo

Authors: Eirini Giannakopoulou , Madeleine Lehander , Stina Virding Culleton , Weiwen Yang , Yingqian Li , Terhi Karpanen , Tetsuichi Yoshizato , Even H Rustad , Morten Milek Nielsen , Ravi Chand Bollineni , Trung T Tran , Marina Delic-Sarac , Thea Johanne Gjerdingen , Karolos Douvlataniotis , Maarja Laos , Muhammad Ali , Amy Hillen , Stefania Mazzi , Desmond Wai Loon Chin , Adi Mehta , Jeppe Sejerø Holm , Amalie Kai Bentzen , Marie Bill , Marieke Griffioen , Tobias Gedde-Dahl, Sören Lehmann , Sten Eirik W Jacobsen , Petter S Woll , Johanna Olweus

Journal: Nat Cancer .

PubMed ID: 37783807

Doi: 10.1038/s43018-023-00642-8

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High-risk histological subtype-related FAM83A hijacked FOXM1 transcriptional regulation to promote malignant progression in lung adenocarcinoma

Authors: Wei Fei, Yan Yan, Guangjun Liu, Bo Peng, Yuanyuan Liu, Qiang Chen

Journal: PeerJ

PubMed ID: 37904848

Doi: 10.7717/peerj.16306

Products & Services: Recombinant Proteins

Sulforaphane alleviates the meiosis defects induced by 3-nitropropionic acid in mouse oocytes

Authors: Wei-Jian Li, Xuan Zhang, Ming Shen, Hong-Lin Liu, Li-Ren Ding

Journal: Food Chem Toxicol

PubMed ID: 37783421

Doi: 10.1016/j.fct.2023.114083

Products & Services: Molecular Biology Reagents

Identification and evaluation in-vitro of conserved peptides with high affinity to MHC-I as potential protective epitopes for Newcastle disease virus vaccines

Authors: Luis Tataje-Lavanda, Edith Málaga, Manuela Verastegui, Egma Mayta Huatuco, Eliana Icochea, Manolo Fernández-Díaz, Mirko Zimic

Journal: BMC Vet Res

PubMed ID: 37805566

Doi: 10.1186/s12917-023-03726-w

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Discovering human cell-compatible gene therapy virus variants via optimized screening in mouse models

Authors: Moyu Dai, Ning Yang, Kai Xu, Jingwen Zhang, Xueke Li, Ying Zhang, Wei Li

Journal: Cell Prolif

PubMed ID: 37864397

Doi: 10.1111/cpr.13565

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A novel metalloproteinase-derived cryptide from Bothrops cotiara venom inhibits angiotensin-converting enzyme activity

Authors: Jackson Gabriel Miyamoto, Eduardo Shigueo Kitano, André Zelanis, Pedro Gabriel Nachtigall, Inácio Junqueira-de-Azevedo, Sávio Stefanini Sant'Anna, Rogério Lauria da Silva, Patrícia Alessandra Bersanetti, Adriana Karaoglanovic Carmona, Pedro José Barbosa Pereira, Solange M T Serrano, Maria Luiza Vilela Oliva, Alexandre Keiji Tashima

Journal: Biochimie

PubMed ID: 37839625

Doi: 10.1016/j.biochi.2023.10.010

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Requires the Type II Secretion System for Pathogenicity and Survival in Grapevine

Authors: Brian Ingel, Claudia Castro, Lindsey Burbank, Nancy Her, N Itzel De Anda, Hannah Way, Peng Wang, M Caroline Roper

Journal: Mol Plant Microbe Interact

PubMed ID: 37188464

Doi: 10.1094/MPMI-03-23-0027-R

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MiR-143-3p/FNDC5 axis: a novel regulator of insulin sensitivity

Authors: Biao Li, Ying Dong, Siyuan Hu, Tiancai Liu

Journal: Endocrine

PubMed ID: 37815745

Doi: 10.1007/s12020-023-03522-4

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Development of a counterselectable system for rapid and efficient CRISPR-based genome engineering in Zymomonas mobilis

Authors: Yanli Zheng, Hongmei Fu, Jue Chen, Jie Li, Yuejie Bian, Ping Hu, Lei Lei, Yihan Liu, Jiangke Yang, Wenfang Peng

Journal: Microb Cell Fact

PubMed ID: 37833755

Doi: 10.1186/s12934-023-02217-9

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An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2/PTBP1 pan-adenocarcinoma

Authors: Zunyong Feng, Xuanbo Zhang, Jing Zhou, Qiang Li, Liuxi Chu, Guangfu Di, Zhengyuan Xu, Qun Chen, Ming Wang, Xiaochun Jiang, Hongping Xia, Xiaoyuan Chen

Journal: Nat Cancer

PubMed ID: 37845485

Doi: 10.1038/s43018-023-00650-8

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Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases

Authors: Shaojie Cui, Anchal Ghai, Yaqin Deng, Shili Li, Ruihui Zhang, Christopher Egbulefu, Guosheng Liang, Samuel Achilefu, Jin Ye

Journal: Mol Cell

PubMed ID: 37863053

Doi: 10.1016/j.molcel.2023.09.025

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Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells

Authors: Olalekan H Usman, Sampath Kumar, Reddick R Walker, Gengqiang Xie, Hyeje C Sumajit, AbdelAziz R Jalil, Subramanian Ramakrishnan, Lawrence J Dooling, Yue Julia Wang, Jerome Irianto

Journal: Mol Biol Cell

PubMed ID: 37903222

Doi: 10.1091/mbc.E23-02-0075

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Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae

Authors: Yu-Min Li, Yu-Chao Mei, Ao-Hui Liu, Ru-Xin Wang, Runfa Chen, Hai-Ning Du

Journal: Cell Rep

PubMed ID: 37796660

Doi: 10.1016/j.celrep.2023.113186

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