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Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy

Authors: Daoyuan Xie , Yaomei Tian , Die Hu , Yuanda Wang , Yuling Yang , Bailing Zhou , Rui Zhang , Zhixiang Ren , Mohan Liu , Jie Xu , Chunyan Dong , Binyan Zhao , Li Yang

Journal: Signal Transduct Target Ther .

PubMed ID: 38016957

Doi: 10.1038/s41392-023-01683-2

Products & Services: Protein Electrophoresis and Western

Structural insights into asymmetric activation of the calciumsensing receptor–Gq complex

Authors: Shenglong Ling, Xianyu Meng, Yuan Zhang, Zhemin Xia, Yingxin Zhou, Fan Yang, Pan Shi, Chaowei Shi, Changlin Tian

Journal: Cell Res .

PubMed ID: 37919470

Doi: 10.1038/s41422-023-00892-2

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Diurnal regulation of alternative splicing associated with thermotolerance in rice by two glycine-rich RNA-binding proteins

Authors: Chuang Yang, Anni Luo, Hai-Ping Lu, Seth Jon Davis, Jian-Xiang Liu

Journal: Sci Bull (Beijing)

PubMed ID: 38044192

Doi: 10.1016/j.scib.2023.11.046

Products & Services: Protein and Antibody Isolation

Structural and biophysical properties of a [4Fe4S] ferredoxin-like protein from Synechocystis sp PCC 6803 with a unique two domain structure

Authors: Effie Kisgeropoulos, Vivek S Bharadwaj, Anastasia Ledinina, Carolyn E Lubner, David W Mulder, Sharon L Smolinski, Marko Boehm, Kirstin Gutekunst, Paul W King, Drazenka Svedruzic

Journal: J Inorg Biochem

PubMed ID: 38008043

Doi: 10.1016/j.jinorgbio.2023.112428

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Acidic pH or salt treatment can convert soluble antibody aggregates in culture harvest into monomers and improve Protein A chromatography step yield

Authors: Ting Zhang, Bin Li, Wanyuan Dong, Yan Wan, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 37939750

Doi: 10.1016/j.pep.2023.106391

Products & Services: Protein Electrophoresis and Western

Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations

Authors: Fiona L Wong, Thomas A Bunch, Victoria C Lepak, Allison L Steedman, Brett A Colson

Journal: J Mol Cell Cardiol

PubMed ID: 38008210

Doi: 10.1016/j.yjmcc.2023.11.010

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Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2

Authors: Shengnan Zhu, Qingning Yuan, Xinzhu Li, Xinheng He, Shiyi Shen, Dongxue Wang, Junrui Li, Xi Cheng, Xiaoqun Duan, H Eric Xu, Jia Duan

Journal: Cell Rep

PubMed ID: 37952153

Doi: 10.1016/j.celrep.2023.113406

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Non-canonical MLL1 activity regulates centromeric phase separation and genome stability

Authors: Liang Sha, Zi Yang, Sojin An, Wentao Yang, Sungmin Kim, Hoon Oh, Jing Xu, Jun Yin, He Wang, Heinz-Josef Lenz, Woojin An, Uhn-Soo Cho, Yali Dou

Journal: Nat Cell Biol

PubMed ID: 37945831

Doi: 10.1038/s41556-023-01270-1

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Genetic manipulation of giant viruses and their host, Acanthamoeba castellanii

Authors: Nadege Philippe, Avi Shukla, Chantal Abergel, Hugo Bisio

Journal: Nat Protoc

PubMed ID: 37964008

Doi: 10.1038/s41596-023-00910-y

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ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer

Authors: Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma

Journal: Cell Signal

PubMed ID: 38000525

Doi: 10.1016/j.cellsig.2023.110979

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Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19

Authors: Maya F Amjadi, Maxwell H Parker, Ryan R Adyniec, Zihao Zheng, Alex M Robbins, S Janna Bashar, Michael F Denny, Sara S McCoy, Irene M Ong, Miriam A Shelef

Journal: J Autoimmun

PubMed ID: 37956528

Doi: 10.1016/j.jaut.2023.103132

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RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms

Authors: Sudarsan Mugunthan, Lan Li Wong, Fernaldo Richtia Winnerdy, Stephen Summers, Muhammad Hafiz Bin Ismail, Yong Hwee Foo, Tavleen Kaur Jaggi, Oliver W Meldrum, Pei Yee Tiew, Sanjay H Chotirmall, Scott A Rice, Anh Tuân Phan, Staffan Kjelleberg, Thomas Seviour

Journal: Nat Commun

PubMed ID: 38012164

Doi: 10.1038/s41467-023-43533-3

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Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors

Authors: Mikhail Rudinskiy, Maria Pons-Vizcarra, Tatiana Soldà, Ilaria Fregno, Timothy Jan Bergmann, Ana Ruano, Aida Delgado, Sara Morales, Xavier Barril, Manolo Bellotto, Elena Cubero, Ana María García-Collazo, Natalia Pérez-Carmona, Maurizio Molinari

Journal: PLoS ONE

PubMed ID: 38019733

Doi: 10.1371/journal.pone.0294437

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Galectin-14 promotes hepatocellular carcinoma tumor growth enhancing heparan sulfate proteoglycan modification

Authors: Liming Gou, Gang Yang, Sujuan Ma, Tong Ding, Luan Sun, Fang Liu, Jin Huang, Wei Gao

Journal: J Biomed Res

PubMed ID: 37977559

Doi: 10.7555/JBR.37.20230085

Products & Services: Protein and Antibody Isolation

EBF2 Links KMT2D-Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN

Authors: Bing Yao, Mengying Xing, Shixin Meng, Shang Li, Jingwan Zhou, Ming Zhang, Chen Yang, Shuang Qu, Yucui Jin, Hongyan Yuan, Ke Zen, Changyan Ma

Journal: Adv Sci (Weinh)

PubMed ID: 38015024

Doi: 10.1002/advs.202302037

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Functional Characterization of Novel Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar

Authors: Idris Mohammed, Senthil Selvaraj, Wesam S Ahmed, Tara Al-Barazenji, Ayat S Hammad, Hajar Dauleh, Luis R Saraiva, Mashael Al-Shafai, Khalid Hussain

Journal: Int J Mol Sci

PubMed ID: 38003551

Doi: 10.3390/ijms242216361

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Regulation of Atg8 membrane deconjugation by cysteine proteases in the malaria parasite Plasmodium berghei

Authors: Akancha Mishra, Aastha Varshney, Satish Mishra

Journal: Cell Mol Life Sci

PubMed ID: 37910326

Doi: 10.1007/s00018-023-05004-2

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Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance

Authors: Yanping Yang, Raymond Louie, Janusz Puc, Yogindra Vedvyas, Yago Alcaina, Irene M Min, Matt Britz, Fabio Luciani, Moonsoo M Jin

Journal: Cancers (Basel)

PubMed ID: 38067255

Doi: 10.3390/cancers15235552

Products & Services: Protein and Antibody Isolation

A nanoparticle vaccine displaying the ookinete PSOP25 antigen elicits transmission-blocking antibody response against Plasmodium berghei

Authors: Guixiang Yao, Hui Min, Xinxin Yu, Fei Liu, Liwang Cui, Yaming Cao

Journal: Parasit Vectors

PubMed ID: 37932796

Doi: 10.1186/s13071-023-06020-8

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Suburban Population of Bobcats (Lynx rufus) in Connecticut, USA, Tested Negative for SARS-CoV-2, November 2021-February 2022

Authors: Maureen Sims, Zeinab Helal, Milton Levin, Tracy Rittenhouse, Jason Hawley, Guillermo R Risatti

Journal: J Wildl Dis

PubMed ID: 37924242

Doi: 10.7589/JWD-D-23-00054

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Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron

Authors: Daniela Bottero, Erika Rudi, Pablo Martin Aispuro, Eugenia Zurita, Emilia Gaillard, Maria M Gonzalez Lopez Ledesma, Juan Malito, Matthew Stuible, Nicolas Ambrosis, Yves Durocher, Andrea V Gamarnik, Andrés Wigdorovitz, Daniela Hozbor

Journal: Front Immunol

PubMed ID: 38022542

Doi: 10.3389/fimmu.2023.1271209

Products & Services: Protein and Antibody Isolation

Dynamics of Serum-Neutralizing Antibody Responses in Vaccinees through Multiple Doses of the BNT162b2 Vaccine

Authors: Jared Sheehan, Caleb M Ardizzone, Mayank Khanna, Amber J Trauth, Michael E Hagensee, Alistair J Ramsay

Journal: Vaccines (Basel)

PubMed ID: 38006052

Doi: 10.3390/vaccines11111720

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Enhancing the Physicochemical Attributes of Dough and Noodles through the Incorporation of Laccase

Authors: Xiaoyu Zhu, Shijin Zhang, Luyao Bian, Juan Shen, Chong Zhang, Sivakumar Manickam, Yang Tao, Zhaoxin Lu

Journal: Foods

PubMed ID: 38002203

Doi: 10.3390/foods12224146

Products & Services: Protein and Antibody Isolation

Cytoplasmic production of Fabs in chemically defined media in fed-batch fermentation

Authors: Angel Castillo-Corujo, Mirva J Saaranen, Lloyd W Ruddock

Journal: Protein Expr Purif

PubMed ID: 37979630

Doi: 10.1016/j.pep.2023.106404

Products & Services: Protein and Antibody Isolation

Laminin β4 is a constituent of the cutaneous basement membrane zone and additional autoantigen of anti-p200 pemphigoid

Authors: Stephanie Goletz, Manuela Pigors, Tina Rastegar Lari, Christoph M Hammers, Yao Wang, Shirin Emtenani, Monique Aumailley, Maike M Holtsche, Felix H Stang, Imke Weyers, Inke R König, Cristina Has, Christiane Radzimski, Lars Komorowski, Detlef Zillikens, Enno Schmidt

Journal: J Am Acad Dermatol

PubMed ID: 37992812

Doi: 10.1016/j.jaad.2023.11.014

Products & Services: Protein and Antibody Isolation

Identification of Protein-Phenol Adducts in Meat Proteins: A Molecular Probe Technology Study

Authors: Fenhong Yang, Yingying Zhu, Xiaohan Li, Fengtao Xiang, Moru Deng, Wei Zhang, Wei Song, Hao Sun, Changbo Tang

Journal: Foods

PubMed ID: 38231694

Doi: 10.3390/foods12234225

Products & Services: Protein Electrophoresis and Western

Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight

Authors: Min-Zhi Chen, Ping Xie, Xiao-Chang Wu, Zhen-Hua Tan, Hai Qian, Zhi-Hong Ma, Xing Yao

Journal: Hepatobiliary Pancreat Dis Int

PubMed ID: 38040523

Doi: 10.1016/j.hbpd.2023.11.007

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Identification of mouse CD4 T cell epitopes in SARS-CoV-2 BA1 spike and nucleocapsid for use in peptide:MHCII tetramers

Authors: Laura Bricio Moreno, Juliana Barreto de Albuquerque, Jake M Neary, Thao Nguyen, Kathryn M Hastie, Sara Landeras-Bueno, Chitra Hariharan, Anusha Nathan, Matthew A Getz, Alton C Gayton, Ashok Khatri, Gaurav D Gaiha, Erica Ollmann Saphire, Andrew D Luster, James J Moon

Journal: biorxiv

PubMed ID: 38014059

Doi: 10.1101/2023.11.16.566918

Products & Services: Protein and Antibody Isolation

Chemical protein synthesis enabled engineering of saccharide oxidative cleavage activity in artificial metalloenzymes

Authors: Jindi Luo, Chunmao He

Journal: Int J Biol Macromol

PubMed ID: 38000595

Doi: 10.1016/j.ijbiomac.2023.128083

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Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51

Authors: Lei Tao, Yue Zhou, Xiangyu Pan, Yuan Luo, Jiahao Qiu, Xia Zhou, Zhiqian Chen, Yan Li, Lian Xu, Yang Zhou, Zeping Zuo, Chunqi Liu, Liang Wang, Xiaocong Liu, Xinyu Tian, Na Su, Zhengnan Yang, Yu Zhang, Kun Gou, Na Sang, Huan Liu, Jiao Zou, Yuzhou Xiao, Xi Zhong, Jing Xu, Xinyu Yang, Kai Xiao, Yanyang Liu, Shengyong Yang, Yong Peng, Junhong Han, Xiaobo Cen, Yinglan Zhao

Journal: Nat Commun

PubMed ID: 37973845

Doi: 10.1038/s41467-023-42850-x

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Molecular Analysis of a Congenital Myasthenic Syndrome Due to a Pathogenic Variant Affecting the C-Terminus of ColQ

Authors: Susie Barbeau, Fannie Semprez, Alexandre Dobbertin, Laurine Merriadec, Florine Roussange, Bruno Eymard, Damien Sternberg, Emmanuel Fournier, Hanice Karasoy, Cécile Martinat, Claire Legay

Journal: Int J Mol Sci

PubMed ID: 38003406

Doi: 10.3390/ijms242216217

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Author Correction: A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques

Authors: Ting Bian, Meng Hao, Xiaofan Zhao, Chuanyi Zhao, Gang Luo, Zhendong Zhang, Guangcheng Fu, Lu Yang, Yi Chen, Yudong Wang, Changming Yu, Yilong Yang, Jianmin Li, Wei Chen

Journal: npj Vaccines

PubMed ID: 38017028

Doi: 10.1038/s41541-023-00780-1

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A Subunit Vaccine Candidate Composed of Mpox Virus A29L, M1R, A35R, and B6R Elicits Robust Immune Response in Mice

Authors: Xuetao Yang , Xidan Yang , Shouwen Du , Congxia Hu , Xiu Yang , Xingyun Wang , Xing Hu , Nino Rcheulishvili , Peng George Wang and Jihui Lin

Journal: Vaccines.

Doi: 10.3390/vaccines11091420

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Fluorescence-quenching lateral flow immunoassay for “turn-on” and sensitive detection of anti-SARS-CoV-2 neutralizing antibodies in human serum

Authors: Lun Bian , Qiangqiang Fu , Zhuoheng Gan , Ze Wu , Yuchen Song , Yufeng Xiong , Fang Hu, Lei Zheng

Journal: Adv Sci (Weinh) .

PubMed ID: 38032112

Doi: 10.1002/advs.202305774

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Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine

Authors: Yang Zang , Shaorui Liu , Zebing Rao , Yinsheng Wang , Boya Zhang , Hui Li , Yingjiao Cao , Jie Zhou , Zhuxia Shen , Shengzhong Duan , Danyang He , Heping Xu

Journal: Immunity .

PubMed ID: 37714152

Doi: 10.1016/j.immuni.2023.08.019

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Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding

Authors: Zhi Li , Ning Wu , Jing Wang , Yang Yue , Lihua Geng , Quanbin Zhang

Journal: Br J Pharmacol .

PubMed ID: 37994102

Doi: 10.1111/bph.16288

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Interplay between stochastic enzyme activity and microtubule stability drives detyrosination enrichment on microtubule subsets

Authors: Qing Tang, Sebastian Sensale, Charles Bond, Jiazheng Xing, Andy Qiao, Siewert Hugelier, Arian Arab, Gaurav Arya, Melike Lakadamyali

Journal: Curr Biol

PubMed ID: 37979580

Doi: 10.1016/j.cub.2023.10.068

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DNA Condensation by Peptide-Conjugated PAMAM Dendrimers Influence of Peptide Charge

Authors: Corinna Dannert, Ingrid Mardal, Rahmi Lale, Bjørn Torger Stokke, Rita S Dias

Journal: ACS Omega

PubMed ID: 38046290

Doi: 10.1021/acsomega.3c05140

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Inflammation primes the kidney for recovery by activating AZIN1 A-to-I editing

Authors: Segewkal Heruye, Jered Myslinski, Chao Zeng, Amy Zollman, Shinichi Makino, Azuma Nanamatsu, Quoseena Mir, Sarath Chandra Janga, Emma H Doud, Michael T Eadon, Bernhard Maier, Michiaki Hamada, Tuan M Tran, Pierre C Dagher, Takashi Hato

Journal: biorxiv

PubMed ID: 37986799

Doi: 10.1101/2023.11.09.566426

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Dual function of Zika virus NS2B-NS3 protease

Authors: Sergey A Shiryaev, Piotr Cieplak, Anton Cheltsov, Robert C Liddington, Alexey V Terskikh

Journal: PLoS Pathog

PubMed ID: 38011215

Doi: 10.1371/journal.ppat.1011795

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Engineering the synthetic β-alanine pathway in Komagataella phaffii for conversion of methanol into 3-hydroxypropionic acid

Authors: Sílvia Àvila-Cabré, Míriam Pérez-Trujillo, Joan Albiol, Pau Ferrer

Journal: Microb Cell Fact

PubMed ID: 37978380

Doi: 10.1186/s12934-023-02241-9

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The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription

Authors: Jordan Jennings, Harrison Bracey, Danny T Nguyen, Rishav Dasgupta, Alondra Vázquez Rivera, Nicolas Sluis-Cremer, Jiong Shi, Christopher Aiken

Journal: biorxiv

PubMed ID: 37986899

Doi: 10.1101/2023.11.08.566350

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Human mesenchymal stem cells derived from adipose tissue showed a more robust effect than those from the umbilical cord in promoting corneal graft survival by suppressing lymphangiogenesis

Authors: Huanmin Kang, Jianing Feng, Yingqian Peng, Yingyi Liu, Yalei Yang, Ying Wu, Jian Huang, Ying Jie, Baihua Chen, Yan He

Journal: Stem Cell Res Ther

PubMed ID: 37957770

Doi: 10.1186/s13287-023-03559-2

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An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

Authors: Hannah Mende, Anshu Khatri, Carolin Lange, Sergio Alejandro Poveda-Cuevas, Georg Tascher, Adriana Covarrubias-Pinto, Frank Löhr, Sebastian E Koschade, Ivan Dikic, Christian Münch, Anja Bremm, Lorenzo Brunetti, Christian H Brandts, Hannah Uckelmann, Volker Dötsch, Vladimir V Rogov, Ramachandra M Bhaskara, Stefan Müller

Journal: Cell Rep

PubMed ID: 37999976

Doi: 10.1016/j.celrep.2023.113484

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Dual-systems models of the genetic architecture of impulsive personality traits: neurogenetic evidence of distinct but related factors

Authors: Alex P Miller, Ian R Gizer

Journal: Psychol Med

PubMed ID: 38016992

Doi: 10.1017/S0033291723003367

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Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway

Authors: Karim H Saba, Valeria Difilippo, Michal Kovac, Louise Cornmark, Linda Magnusson, Jenny Nilsson, Hilda van den Bos, Diana Cj Spierings, Mahtab Bidgoli, Tord Jonson, Vaiyapuri P Sumathi, Otte Brosjö, Johan Staaf, Floris Foijer, Emelie Styring, Michaela Nathrath, Daniel Baumhoer, Karolin H Nord

Journal: J Pathol

PubMed ID: 38010733

Doi: 10.1002/path.6219

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Cold atmospheric plasma can effectively disinfect SARS-CoV-2 in the wastewater

Authors: Hongbo Qin, Hengju Qiu, Ke Liu, Bixia Hong, Yuchen Liu, Chun Li, Mengzhe Li, Xiaoping An, Lihua Song, Eric Robert, Yigang Tong, Huahao Fan, Ruixue Wang

Journal: Exploration (Beijing)

PubMed ID: 38939868

Doi: 10.1002/EXP.20230012

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Varying the RGD concentration on a hyaluronic acid hydrogel influences dormancy versus proliferation in brain metastatic breast cancer cells

Authors: Kasra Goodarzi, Rachel Lane, Shreyas S Rao

Journal: J Biomed Mater Res A

PubMed ID: 38018303

Doi: 10.1002/jbm.a.37651

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Characterization of an L-Arabinose Isomerase from Bacillus velezensis and Its Application for L-Ribulose and L-Ribose Biosynthesis

Authors: Zongren Guo, Liangkun Long, Shaojun Ding

Journal: Appl Biochem Biotechnol

PubMed ID: 32617845

Doi: 10.1007/s12010-020-03380-0

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Self−Assembling Nanovaccine Fused with Flagellin Enhances Protective Effect against Foot−and−Mouth Disease Virus

Authors: Chenchen Pei , Hu Dong , Zhidong Teng , Sumin Wei , Yun Zhang , Shuanghui Yin , Jianli Tang , Shiqi Sun and Huichen Guo

Journal: Vaccines

Doi: 10.3390/vaccines11111675

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