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Arabidopsis calmodulin-like proteins CML13 and CML14 interact with proteins that have IQ domains

Authors: Howard J Teresinski, Bryan Hau, Kyle Symonds, Ryan Kilburn, Kim A Munro, Nathan M Doner, Robert Mullen, Vivian H Li, Wayne A Snedden

Journal: Plant Cell Environ

PubMed ID: 37222394

Doi: 10.1111/pce.14616

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Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants

Authors: Jianbo Wu, Zhenguo Chen, Yidan Gao, Zegen Wang, Jiarong Wang, Bing-Yu Chiang, Yunjiao Zhou, Yuru Han, Wuqiang Zhan, Minxiang Xie, Weiyu Jiang, Xiang Zhang, Aihua Hao, Anqi Xia, Jiaying He, Song Xue, Christian T Mayer, Fan Wu, Bin Wang, Lunan Zhang, Lei Sun, Qiao Wang

Journal: Cell Rep

PubMed ID: 37178120

Doi: 10.1016/j.celrep.2023.112503

Products & Services: Catalog Peptides

Design and application of artificial rare L-lysine codons in Corynebacterium glutamicum

Authors: Cuiping Yang , Zehao Peng , Lu Yang , Bowen Du , Chuanzhuang Guo , Songsen Sui , Jianbin Wang , Junlin Li , Junqing Wang , Nan Li

Journal: Front Bioeng Biotechnol

PubMed ID: 7324439

Doi: 10.3389/fbioe.2023.1194511

Products & Services: Gene Synthesis

JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding

Authors: Carlos G Ardanaz, Amaia Ezkurdia, Arantza Bejarano, Beatriz Echarte, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramírez, Maite Solas

Journal: ACS Chem Neurosci

PubMed ID: 37236204

Doi: 10.1021/acschemneuro.3c00092

Products & Services: Proteins, Expression, Isolation and Analysis

CLASPs stabilize the pre-catastrophe intermediate state between microtubule growth and shrinkage

Authors: Elizabeth J Lawrence, Saptarshi Chatterjee, Marija Zanic

Journal: J Cell Biol

PubMed ID: 37184584

Doi: 10.1083/jcb.202107027

Products & Services: Proteins, Expression, Isolation and Analysis

Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent

Authors: Xu Hou, Taylor Hsuan-Yu Chen, Shunsuke Koga, Jenny M Bredenberg, Ayman H Faroqi, Marion Delenclos, Guojun Bu, Zbigniew K Wszolek, Jonathan A Carr, Owen A Ross, Pamela J McLean, Melissa E Murray, Dennis W Dickson, Fabienne C Fiesel, Wolfdieter Springer

Journal: Brain Pathol

PubMed ID: 37259617

Doi: 10.1111/bpa.13175

Products & Services: Proteins, Expression, Isolation and Analysis

Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity

Authors: Esha Pandit, Lopamudra Das, Anoy Kumar Das, Sandip Dolui, Saumen Saha, Uttam Pal, Animesh Mondal, Joydeep Chowdhury, Subhas C Biswas, Nakul C Maiti

Journal: Front Chem

PubMed ID: 37304685

Doi: 10.3389/fchem.2023.1145877

Products & Services: Proteins, Expression, Isolation and Analysis

Massively parallel evaluation and computational prediction of the activities and specificities of 17 small Cas9s

Authors: Sang-Yeon Seo, Seonwoo Min, Sungtae Lee, Jung Hwa Seo, Jinman Park, Hui Kwon Kim, Myungjae Song, Dawoon Baek, Sung-Rae Cho, Hyongbum Henry Kim

Journal: Nat Methods

PubMed ID: 37188955

Doi: 10.1038/s41592-023-01875-2

Products & Services: Molecular Biology Reagents

The effects of free Cys residues on the structure, activity, and tetrameric stability of mammalian uricase

Authors: Yong Guo, Jingjing Huo, Runchao Bai, Jingyuan Zhang, Jipeng Yao, Kaijie Ma, Zengtao Zhang, Haigang Li, Chun Zhang

Journal: Appl Microbiol Biotechnol

PubMed ID: 37256327

Doi: 10.1007/s00253-023-12597-y

Products & Services: Molecular Biology Reagents

Functional characterization of novel or yet uncharacterized ATP7B missense variants detected in patients with clinical Wilson's disease

Authors: Amelie Stalke, Annika Behrendt, Finja Hennig, Holger Gohlke, Nicole Buhl, Thea Reinkens, Ulrich Baumann, Brigitte Schlegelberger, Thomas Illig, Eva-Doreen Pfister, Britta Skawran

Journal: Clin Genet

PubMed ID: 37157876

Doi: 10.1111/cge.14352

Products & Services: Gene Synthesis

Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases

Authors: Guangxue Liu, Jimin Li, Boxue He, Jiaqi Yan, Jingyu Zhao, Xuejie Wang, Xiaocong Zhao, Jingyan Xu, Yeyao Wu, Simin Zhang, Xiaoli Gan, Chun Zhou, Xiangpan Li, Xinghua Zhang, Xuefeng Chen

Journal: Nat Commun

PubMed ID: 37230987

Doi: 10.1038/s41467-023-38617-z

Products & Services: Recombinant Proteins

Resin and loading condition screening for effective and robust byproducts removal by anion exchange chromatography: A case study

Authors: Wei Chen, Peter K Wang, Chien-Chun Liao, Yifeng Li, Yan Wan

Journal: Protein Expr Purif

PubMed ID: 37209930

Doi: 10.1016/j.pep.2023.106297

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient precise integration of large DNA sequences with 3′-overhang dsDNA donors using CRISPR/Cas9

Authors: Wenjie Han, Zhigang Li, Yijun Guo, Kaining He, Wenqing Li, Caoling Xu, Lishuang Ge, Miao He, Xue Yin, Junxiang Zhou, Chengxu Li, Dongbao Yao, Jianqiang Bao, Haojun Liang

Journal: Proceedings of the national academy of sciences of the USA

PubMed ID: 37216515

Doi: 10.1073/pnas.2221127120

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Vesicular Stomatitis Virus (VSV) G Glycoprotein Can Be Modified to Create a Her2/Neu-Targeted VSV That Eliminates Large Implanted Mammary Tumors

Authors: Yanhua Gao, Ira Bergman

Journal: J Virol

PubMed ID: 37199666

Doi: 10.1128/jvi.00372-23

Products & Services: Proteins, Expression, Isolation and Analysis

Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage

Authors: James D Moody, Sarah Hill, Maike N Lundahl, Aubrianna J Saxton, Amanda Galambas, William E Broderick, C Martin Lawrence, Joan B Broderick

Journal: J Biol Chem

PubMed ID: 37156396

Doi: 10.1016/j.jbc.2023.104791

Products & Services: Proteins, Expression, Isolation and Analysis

Full-length versus truncated α-factor secretory signal sequences for expression of recombinant human insulin precursor in yeast Pichia pastoris: a comparison

Authors: Nuruliawaty Utami, Dini Nurdiani, Hariyatun Hariyatun, Eko Wahyu Putro, Fadillah Putri Patria, Wien Kusharyoto

Journal: J Genet Eng Biotechnol

PubMed ID: 37212962

Doi: 10.1186/s43141-023-00521-w

Products & Services: Proteins, Expression, Isolation and Analysis

A glycan receptor kinase facilitates intracellular accommodation of arbuscular mycorrhiza and symbiotic rhizobia in the legume Lotus japonicus

Authors: Simon Kelly, Simon B Hansen, Henriette Rübsam, Pia Saake, Emil B Pedersen, Kira Gysel, Eva Madland, Shunliang Wu, Stephan Wawra, Dugald Reid, John T Sullivan, Zuzana Blahovska, Maria Vinther, Artur Muszynski, Parastoo Azadi, Mikkel B Thygesen, Finn L Aachmann, Clive W Ronson, Alga Zuccaro, Kasper R Andersen, Simona Radutoiu, Jens Stougaard

Journal: PLoS Biol

PubMed ID: 37200394

Doi: 10.1371/journal.pbio.3002127

Products & Services: Proteins, Expression, Isolation and Analysis

Multiplexed Gene Engineering Based on dCas9 and gRNA-tRNA Array Encoded on Single Transcript

Authors: Chaoqian Jiang, Lishuang Geng, Jinpeng Wang, Yingjuan Liang, Xiaochen Guo, Chang Liu, Yunjing Zhao, Junxue Jin, Zhonghua Liu, Yanshuang Mu

Journal: Int J Mol Sci

PubMed ID: 37239880

Doi: 10.3390/ijms24108535

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9

Authors: Gregory M Martin, Monica L Fernández-Quintero, Wen-Hsin Lee, Tossapol Pholcharee, Lisa Eshun-Wilson, Klaus R Liedl, Marie Pancera, Robert A Seder, Ian A Wilson, Andrew B Ward

Journal: Nat Commun

PubMed ID: 37198165

Doi: 10.1038/s41467-023-38509-2

Products & Services: Codon Optimization

An efficient transformation method for genome editing of elite bread wheat cultivars

Authors: Akshaya K Biswal, L Ruben B Hernandez, Ana I R Castillo, Juan M Debernardi, Kanwarpal S Dhugga

Journal: Front Plant Sci

PubMed ID: 37275249

Doi: 10.3389/fpls.2023.1135047

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L-Lactate treatment by photosynthetic cyanobacteria expressing heterogeneous L-lactate dehydrogenase

Authors: Yuichi Kato, Kosuke Inabe, Yuji Haraguchi, Tatsuya Shimizu, Akihiko Kondo, Tomohisa Hasunuma

Journal: Sci Rep

PubMed ID: 37142758

Doi: 10.1038/s41598-023-34289-3

Products & Services: Gene Synthesis

A rapidly evolving single copy histone H1 variant is associated with male fertility in a parasitoid wasp

Authors: Bo Yuan, Yi Yang, Zhichao Yan, Chun He, Yu H Sun, Fei Wang, Beibei Wang, Jiamin Shi, Shan Xiao, Fang Wang, Qi Fang, Fei Li, Xinhai Ye, Gongyin Ye

Journal: Front Cell Dev Biol

PubMed ID: 37325562

Doi: 10.3389/fcell.2023.1166517

Products & Services: Monoclonal Antibody Services

Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus

Authors: Masashi Nishikawa, Hikari Okada, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, Kuniaki Arai, Tatsuya Yamashita, Motoko Sasaki, Shuichi Kaneko, Taro Yamashita, Masao Honda

Journal: Cell Mol Gastroenterol Hepatol

PubMed ID: 37146715

Doi: 10.1016/j.jcmgh.2023.04.006

Products & Services: Proteins, Expression, Isolation and Analysis

Modular Hydrogel Vaccine for Programmable and Coordinate Elicitation of Cancer Immunotherapy

Authors: Panpan Ji, Wenqi Sun, Siyan Zhang, Yuqi Xing, Chen Wang, Mengying Wei, Qiuyun Li, Gang Ji, Guodong Yang

Journal: Adv Sci (Weinh)

PubMed ID: 37222047

Doi: 10.1002/advs.202301789

Products & Services: Proteins, Expression, Isolation and Analysis

The free-living flagellate Paratrimastix pyriformis uses a distinct mitochondrial carrier to balance adenine nucleotide pools

Authors: Justyna Zítek, Martin S King, Priscila Peña-Diaz, Eva Pyrihová, Alannah C King, Edmund R S Kunji, Vladimír Hampl

Journal: Arch Biochem Biophys

PubMed ID: 37192692

Doi: 10.1016/j.abb.2023.109638

Products & Services: Proteins, Expression, Isolation and Analysis

The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms

Authors: Duy Lan Huong Bui, Andrew Roach, Jingxian Li, Sumit J Bandekar, Elizabeth Orput, Ritika Raghavan, Demet Araç, Richard C Sando

Journal: Cell Rep

PubMed ID: 37224017

Doi: 10.1016/j.celrep.2023.112552

Products & Services: Molecular Biology Reagents

Antimicrobial activity of the Flo peptide produced in Scenedesmus acutus and Nannochloropsis oculata

Authors: Saraí Damaris Dávalos-Guzmán, Fidel Martinez-Gutierrez, Luzmila Martínez-González, Jesús Josafath Quezada-Rivera, Ana Cecilia Lorenzo-Leal, Horacio Bach, José Francisco Morales-Domínguez, Ruth Elena Soria-Guerra

Journal: World J Microbiol Biotechnol

PubMed ID: 37249711

Doi: 10.1007/s11274-023-03664-7

Products & Services: Gene Synthesis

Circ_0069094 regulates malignant phenotype and paclitaxel resistance in breast cancer cells via targeting the miR-136-5p/YWHAZ axis

Authors: Zhihua Kong, Qi Han, Bisheng Zhu, Long Wan, Enrong Feng

Journal: Thorac Cancer

PubMed ID: 37192740

Doi: 10.1111/1759-7714.14928

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Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing

Authors: Christopher C Pan, Raquel Maeso-Díaz, Tylor R Lewis, Kun Xiang, Lianmei Tan, Yaosi Liang, Liuyang Wang, Fengrui Yang, Tao Yin, Calvin Wang, Kuo Du, De Huang, Seh Hoon Oh, Ergang Wang, Bryan Jian Wei Lim, Mengyang Chong, Peter B Alexander, Xuebiao Yao, Vadim Y Arshavsky, Qi-Jing Li, Anna Mae Diehl, Xiao-Fan Wang

Journal: Cell Res

PubMed ID: 37169907

Doi: 10.1038/s41422-023-00820-4

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Improved biosynthesis of heme in Bacillus subtilis through metabolic engineering assisted fed-batch fermentation

Authors: Shaomei Yang, Anlong Wang, Jiachang Li, Yunhang Shao, Fengjie Sun, Shucheng Li, Kai Cao, Hongliang Liu, Peng Xiong, Zhengquan Gao

Journal: Microb Cell Fact

PubMed ID: 37198628

Doi: 10.1186/s12934-023-02077-3

Products & Services: Gene Synthesis

Transcriptome Analysis and Identification of Sesquiterpene Synthases in Liverwort Jungermannia exsertifolia

Authors: Xiaoguang Yan, Yukun Li, Weiguo Li, Dongmei Liang, Shengxin Nie, Ruiqi Chen, Jianjun Qiao, Mingzhang Wen, Qinggele Caiyin

Journal: Bioengineering (Basel) .

PubMed ID: 37237639

Doi: 10.3390/bioengineering10050569

Products & Services: Proteins, Expression, Isolation and Analysis

Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes

Authors: Jonathan D Teo , Oana C Marian , Alanna G Spiteri , Madeline Nicholson , Huitong Song , Jasmine X Y Khor , Holly P McEwen , Anjie Ge , Monokesh K Sen , Laura Piccio , Jessica L Fletcher , Nicholas J C King , Simon S Murray , Jens C Brüning , Anthony S Don

Journal: Glia .

PubMed ID: 36583573

Doi: 10.1002/glia.24329

Products & Services: Recombinant Proteins

A molecular study on recombinant pullulanase type I from Metabacillus indicus.

Authors: Zahraa Z Al-Mamoori , Amira M Embaby , Ahmed Hussein , Hoda E Mahmoud

Journal: AMB Express

PubMed ID: 37119334

Doi: 10.1186/s13568-023-01545-8.

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Adjuvant-Free COVID-19 Vaccine with Glycoprotein Antigen Oxidized by Periodate Rapidly Elicits Potent Immune Responses

Authors: Ru-Yan Zhang, Shi-Hao Zhou, Ran-Ran Feng, Yu Wen, Dong Ding, Zhi-Ming Zhang, Hua-Wei Wei, Jun Guo

Journal: ACS Chemical Biology

PubMed ID: 37009726

Doi: 10.1021/acschembio.3c00050

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LvCD14L Acts as a Novel Pattern Recognition Receptor and a Regulator of the Toll Signaling Pathway in Shrimp

Authors: Xinjia Lv, Shihao Li 1,2,3, Yang Yu, Songjun Jin, Xiaojun Zhang, Fuhua Li

Journal: International Journal of Molecular Sciences

Doi: 10.3390/ijms24097770

Products & Services: Proteins, Expression, Isolation and Analysis eBlot™ L1 Fast Wet Transfer System

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Authors: Dongchun Ni, Priscilla Turelli, Bertrand Beckert, Sergey Nazarov, Emiko Uchikawa, Alexander Myasnikov, Florence Pojer, Didier Trono, Henning Stahlberg, Kelvin Lau

Journal: PLoS pathogens

PubMed ID: 37018380

Doi: 10.1371/journal.ppat.1011206

Products & Services: Gene Synthesis

Knockdown of the salivary protein gene NlG14 caused displacement of the lateral oviduct secreted components and inhibited ovulation in Nilaparvata lugens

Authors: Haoli Gao, Huihui Zhang, Xiaowei Yuan, Xumin Lin, Jianzheng Zou, Na Yu, Zewen Liu

Journal: PLOS Genetics

PubMed ID: 37011098

Doi: 10.1371/journal.pgen.1010704

Products & Services: Proteins, Expression, Isolation and Analysis

Precise integration of large DNA sequences in plant genomes using PrimeRoot editors

Authors: Chao Sun, Yuan Lei, Boshu Li, Qiang Gao, Yunjia Li, Wen Cao, Chao Yang, Hongchao Li, Zhiwei Wang, Yan Li, Yanpeng Wang, Jun Liu, Kevin Tianmeng Zhao, Caixia Gao

Journal: Nature Biotechnology

PubMed ID: 37095350

Doi: 10.1038/s41587-023-01769-w

Products & Services: Gene Synthesis

Protein Delivery to Insect Epithelial Cells In Vivo: Potential Application to Functional Molecular Analysis of Proteins in Butterfly Wing Development

Authors: Yugo Nakazato, Joji M Otaki

Journal: BioTech (Basel)

PubMed ID: 37092472

Doi: 10.3390/biotech12020028

Products & Services: Molecular Biology Reagents

Is Penguin Circovirus Circulating Only in the Antarctic Circle? Lack of Viral Detection in Namibia

Authors: Laura C Roberts, Umberto Molini, Lauren M Coetzee, Siegfried Khaiseb, Jean-Paul Roux, Jessica Kemper, David G Roberts, Katrin Ludynia, Marcus Doherr, Darrell Abernethy, Giovanni Franzo

Journal: Animals (Basel)

PubMed ID: 37174486

Doi: 10.3390/ani13091449

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Novel targeting assay uncovers targeting information within peroxisomal ABC transporter Pxa1

Authors: Renate L M Jansen, Marco van den Noort, Arjen M Krikken, Chen Bibi, Astrid Böhm, Maya Schuldiner, Einat Zalckvar, Ida J van der Klei

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 37028652

Doi: 10.1016/j.bbamcr.2023.119471

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A novel anti-membrane CD30 single-chain variable fragment discovered from the human phage library: A potential targeted immunotherapy

Authors: Thanida Chanpong, Watee Seesuay, Wararat Chiangjong, Piamsiri Jiramornimit, Sarinthip Preedagasamzin, Korakot Atjanasuppat, Bunyada Jittorntrum, Somsak Prasongtanakij, Supannikar Tawinwung, Sulada Pukiat, Chonticha Saisawang, Suparerk Borwornpinyo, Khanit Sa-Ngiamsuntorn, Wanpen Chaichumpa, Suradej Hongeng, Usanarat Anurathapan

Journal: PLoS ONE

PubMed ID: 37079526

Doi: 10.1371/journal.pone.0284708

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FTO promotes cervical cancer cell proliferation, colony formation, migration and invasion via the regulation of the BMP4/Hippo/YAP1/TAZ pathway

Authors: Jinyuan Huang, Jing Yang, Yudi Zhang, Dan Lu, Yinmei Dai

Journal: Exp Cell Res

PubMed ID: 37030332

Doi: 10.1016/j.yexcr.2023.113585

Products & Services: Proteins, Expression, Isolation and Analysis

Chemical shift assignments of calmodulin bound to a cytosolic domain of GluN2A (residues 1004-1024) from the NMDA receptor

Authors: Aritra Bej, James B Ames

Journal: Biomol NMR Assign

PubMed ID: 37029330

Doi: 10.1007/s12104-023-10125-7

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Constitutively activated AMPKα1 protects against skeletal aging in mice by promoting bone-derived IGF-1 secretion

Authors: Yiqi Yang, Kai Yuan, Yihao Liu, Qishan Wang, Yixuan Lin, Shengbing Yang, Kai Huang, Tianyou Kan, Yuxin Zhang, Mingming Xu, Zhifeng Yu, Qiming Fan, Yugang Wang, Hanjun Li, Tingting Tang

Journal: Cell Prolif

PubMed ID: 37042047

Doi: 10.1111/cpr.13476

Products & Services: Proteins, Expression, Isolation and Analysis

ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

Authors: Natalia Jiménez-Moreno, Madhu Kollareddy, Petros Stathakos, Joanna J Moss, Zuriñe Antón, Deborah K Shoemark, Richard B Sessions, Ralph Witzgall, Maeve Caldwell, Jon D Lane

Journal: J Cell Biol

PubMed ID: 37014324

Doi: 10.1083/jcb.201910133

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Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Omicron variant of concern

Authors: Tyler M Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J Hill, Usha D Hemraz, Sophie Régnier, Anne E G Lenferink, Yves Durocher, Michael J McCluskie

Journal: Frontiers in Immunology

PubMed ID: 37122746

Doi: 10.3389/fimmu.2023.1182556

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Baseline corticosterone levels in spadefoot toads reflect alternate larval diets one year later

Authors: Cristina C Ledón-Rettig, Katie M Lo, Sarah R Lagon

Journal: Gen Comp Endocrinol

PubMed ID: 37094616

Doi: 10.1016/j.ygcen.2023.114291

Products & Services: Proteins, Expression, Isolation and Analysis

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism

Authors: Ashley Haluck-Kangas, Madelaine Fink, Elizabeth T Bartom, Marcus E Peter