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Rational Design of Key Enzymes to Efficiently Synthesize Phycocyanobilin in
Authors: Ziwei Wang, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Xinrui Zhao
Journal: Biomolecules
PubMed ID: 38540721
Doi: 10.3390/biom14030301
Products & Services: Protein and Antibody Isolation   
MicroRNA-223-3p downregulates the inflammatory response in preeclampsia placenta via targeting NLRP3
Authors: Xueqiong Liu, Zhiyue Li, Dan Lu
Journal: BMC Pregnancy Childbirth
PubMed ID: 38448875
Doi: 10.1186/s12884-024-06371-9
Products & Services: Gene Synthesis   
Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer
Authors: Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N Gopalakrishna Iyer, Eliza Li Shan Fong
Journal: Adv Sci (Weinh)
PubMed ID: 38493497
Doi: 10.1002/advs.202307129
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Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner
Authors: Yujian Wang, Jingchang Luo, Xiaolu Guan , Yan Zhao , Li Sun
Journal: Cell Death Discov
PubMed ID: 38458999
Doi: 10.1038/s41420-024-01887-7
Products & Services: Protein and Antibody Isolation   
Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9
Authors: Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Xiaohua Guo
Journal: Cell Commun Signal
PubMed ID: 38491522
Doi: 10.1186/s12964-024-01566-1
Products & Services: Recombinant Proteins   
Reactive Oxygen Species-Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression
Authors: Liang Qi, Bo-Wen Duan, Hui Wang, Yan-Jun Liu, Han Han, Meng-Meng Han, Lei Xing, Hu-Lin Jiang, Stephen J Pandol, Ling Li
Journal: Adv Sci (Weinh)
PubMed ID: 38483920
Doi: 10.1002/advs.202401254
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Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes
Authors: Xinrui Zhou , Wan Yi Seow, Norbert Ha, Teh How Cheng, Lingfan Jiang, Jeeranan Boonruangkan, Jolene Jie Lin Goh, Shyam Prabhakar, Nigel Chou, Kok Hao Chen Affiliations expand
Journal: Nat Commun
PubMed ID: 38491027
Doi: s41467-024-46669-y
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Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis
Authors: Shan Gao, Fangyu Wu, Sudagar S Gurcha, Sarah M Batt, Gurdyal S Besra, Zihe Rao, Lu Zhang
Journal: Nature
PubMed ID: 38491273
Doi: 10.1038/s41564-024-01643-8
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The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
Authors: Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, Ying Xia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu, Zhou Songyang
Journal: Cell Research
PubMed ID: 38448650
Doi: 10.1038/s41422-024-00938-z
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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans
Authors: M Alejandra Tortorici, Amin Addetia, Albert J Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler
Journal: Immunity
PubMed ID: 38490197
Doi: 10.1016/j.immuni.2024.02.016
Products & Services: Plasmid DNA Preparation   
Specific protein-RNA interactions are mostly preserved in biomolecular condensates
Authors: Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric H-T Allain
Journal: SCIENCE ADVANCES
PubMed ID: 38446881
Doi: 10.1126/sciadv.adm7435
Products & Services: PCR Cloning and Subcloning   
A uniquely efficacious type of CFTR corrector with complementary mode of action
Authors: Valentina Marchesin, Lucile Monnier, Peter Blattmann, Florent Chevillard, Christine Kuntz, Camille Forny, Judith Kamper, Rolf Studer, Alexandre Bossu, Eric A Ertel, Oliver Nayler, Christine Brotschi, Jodi T Williams, John Gatfield
Journal: SCIENCE ADVANCES
PubMed ID: 38427726
Doi: 10.1126/sciadv.adk1814
Products & Services: PCR Cloning and Subcloning   
FUS reads histone H3K36me3 to regulate alternative polyadenylation
Authors: Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang
Journal: Nucleic Acids Research
PubMed ID: 38499486
Doi: 10.1093/nar/gkae184
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Phage-displayed synthetic library and screening platform for nanobody discovery
Authors: Baolong Xia; Ah-Ram Kim; Feimei Liu; Myeonghoon Han; Emily Stoneburner; Stephanie Makdissi; Francesca Di Cara; Stephanie E Mohr; Aaron Ring; Norbert Perrimon; Ahmad S Khalil; Baolong Xia; Ah-Ram Kim; Feimei Liu; Myeonghoon Han; Emily Stoneburner; Stephanie Makdissi; Francesca Di Cara; Stephanie E Mohr; Aaron Ring; Norbert Perrimon
Journal: Elife
PubMed ID: 40748049
Doi: 10.7554/eLife.105887
Products & Services: Protein and Antibody Isolation   
Phage-displayed synthetic library and screening platform for nanobody discovery
Authors: Baolong Xia; Ah-Ram Kim; Feimei Liu; Myeonghoon Han; Emily Stoneburner; Stephanie Makdissi; Francesca Di Cara; Stephanie E Mohr; Aaron Ring; Norbert Perrimon; Ahmad S Khalil; Baolong Xia; Ah-Ram Kim; Feimei Liu; Myeonghoon Han; Emily Stoneburner; Stephanie Makdissi; Francesca Di Cara; Stephanie E Mohr; Aaron Ring; Norbert Perrimon
Journal: Elife
PubMed ID: 40748049
Doi: 10.7554/eLife.105887
Products & Services: Protein and Antibody Isolation   
Reduction in Interferon-Stimulated Genes Contributes to High-Yield Production of Influenza Virus in Suspension MDCK Cells
Authors: Qi Wang, Jian Luo, Beibei Li, Qian Ye, Wenting Xu, Feixia Gao, Linting Zhou, Wenyue Lu, Wen-Song Tan, Xiuling Li
Journal: Vaccines
PubMed ID: 38543921
Doi: 10.3390/vaccines12030287
Products & Services: Protein and Antibody Isolation   
Identification and expression analysis of family gene in L
Authors: Jiao Xu, Lingyang Kong, Weichao Ren, Zhen Wang, Lili Tang, Wei Wu, Xiubo Liu, Wei Ma, Shuquan Zhang
Journal: Heliyon
PubMed ID: 38545150
Doi: 10.1016/j.heliyon.2024.e27817
Products & Services: Protein and Antibody Isolation   
Correction to "Subtilisin 3 production from Microsporum canis is independent of keratin substrate availability"
Authors:
Journal: J Basic Microbiol
PubMed ID: 38533930
Doi: 10.1002/jobm.202470023
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Identification of the grass carp interleukin-23 receptor and its proinflammatory role in intestinal inflammation
Authors: Panpan Han, Jian Tang, Xufang Xu, Pengkun Meng, Kang Wu, Bingyao Sun, Xuehong Song
Journal: Int J Biol Macromol
PubMed ID: 38521334
Doi: 10.1016/j.ijbiomac.2024.130946
Products & Services: Codon Optimization   
A long-term cohort study: the immune evasion and decreasing neutralization dominated the SARS-CoV-2 breakthrough infection
Authors: Qianyun Liu, Meihua Jin, Fanghua Mei, Hui Fan, Mengxue Gu, Yuzhen Zhang, Shengnan Qian, Xue Tan, Lei Ji, Zhen Zhang, Guozhong Chen, Huan Yan, Yu Chen, Ke Lan, Qing Geng, Kun Cai, Li Zhou
Journal: Front Cell Infect Microbiol
PubMed ID: 38572316
Doi: 10.3389/fcimb.2024.1381877
Products & Services: Protein and Antibody Isolation   
Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9
Authors: John H Kim, Aashish Shivkumar, Masaki Norimoto, Sascha Castro Lingl, Christian Seitz, Rommie E Amaro, Steve L Gonias, Jerry Yang, Wendy M Campana
Journal: Biochemistry
PubMed ID: 38450612
Doi: 10.1021/acs.biochem.3c00705
Products & Services: Molecular Biology Reagents   
Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway
Authors: Quanxin Wang, Ruiqi Zhang, Yijun He, Guangmin Mao, Zhaolu Kong
Journal: Int J Radiat Biol
PubMed ID: 38442139
Doi: 10.1080/09553002.2024.2324475
Products & Services: DNA Sequencing   
Time-dependent enhancement of mRNA vaccines by 4–1BB costimulation
Authors: Sarah Sanchez, Tanushree Dangi, Bakare Awakoaiye, Nahid Irani, Slim Fourati, Justin Richner, Pablo Penaloza-MacMaster
Journal: biorxiv
PubMed ID: 38496467
Doi: 10.1101/2024.03.01.582992
Products & Services: Custom mRNA synthesis   Custom Vector Construction   
An intein-based biosensor to measure protein stability in vivo
Authors: Ahyun Son, John S Smetana, Scott Horowitz , Christopher W Lennon
Journal: Protein Sci
PubMed ID: 38380775
Doi: 10.1002/pro.4925
Products & Services: Gene Synthesis   
Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome
Authors: Rui Bai, Meng Yuan, Pu Zhang, Ting Luo, Yigong Shi, Ruixue Wan
Journal: Science
PubMed ID: 38484052
Doi: 10.1126/science.adn7272
Products & Services: Gene Synthesis   
G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes
Authors: Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Daniel Jutzi, Roland Montserret, Marc-David Ruepp, Romain Parent, Christophe Combet, Fabien Zoulim, Barbara Testoni
Journal: Nucleic Acids Res
PubMed ID: 38113270
Doi: 10.1093/nar/gkad1200
Products & Services: Mutagenesis Services   
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells
Authors: Zhi-Liang Jing, Guang-Long Liu, Na Zhou, Dong-Yan Xu, Na Feng, Yan Lei, Li-Li Ma, Min-Shan Tang, Gui-Hui Tong, Na Tang, Yong-Jian Deng
Journal: Nature
PubMed ID: 38480774
Doi: 10.1038/s41598-024-56681-3
Products & Services: Polyclonal Antibody Services   
Molecular basis for substrate transport of Mycobacterium tuberculosis ABC importer DppABCD
Authors: Tianyu Hu, Xiaolin Yang, Yuanchen Zhu, Fengjiang Liu, Xiuna Yang, Zhiqi Xiong, Jingxi Liang, Zhenli Lin, Yuting Ran, Luke W Guddat, Zihe Rao, Bing Zhang
Journal: SCIENCE ADVANCES
PubMed ID: 38507491
Doi: 10.1126/sciadv.adk8521
Products & Services: Protein and Antibody Isolation   
MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis 
Authors: Nicholas Vrettos, Jan Oppelt, Ansgar Zoch, Paraskevi Sgourdou, Haruka Yoshida, Brian Song, Ryan Fink, Dónal O'Carroll, Zissimos Mourelatos 1
Journal: Nucleic Acids Research
PubMed ID: 38520410
Doi: 10.1093/nar/gkae193
Products & Services: Peptide Synthesis   
Unveiling a Shield of Hope: A Novel Multiepitope-Based Immunogen for Cross-Serotype Cellular Defense against Dengue Virus
Authors: Nilanshu Manocha, Daphné Laubreton, Xavier Robert, Jacqueline Marvel, Virginie Gueguen-Chaignon, Patrice Gouet, Prashant Kumar, Madhu Khanna
Journal: Vaccines (Basel)
PubMed ID: 38543950
Doi: 10.3390/vaccines12030316
Products & Services: Catalog Peptides   
Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease
Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo
Journal: Arthritis Res Ther
PubMed ID: 38509595
Doi: 10.1186/s13075-024-03308-7
Products & Services: Protein and Antibody Isolation   
Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw
Authors: Qu Xz, Sun Zq, Liu L, Ong Hs
Journal: Appl Biochem Biotechnol
PubMed ID: 38523176
Doi: 10.1007/s12010-024-04859-w
Products & Services: Gene Synthesis   
Supra-biological performance of immobilized enzymes enabled by chaperone-like specific non-covalent interactions
Authors: Héctor Sánchez-Morán, Joel L Kaar, Daniel K Schwartz
Journal: Nat Commun
PubMed ID: 38485940
Doi: 10.1038/s41467-024-46719-5
Products & Services: Molecular Biology Reagents   
Structural determination and kinetic analysis of the transketolase from Vibrio vulnificus reveal unexpected cooperative behavior
Authors: Rainier-Numa Georges, Lionel Ballut, Guillaume Octobre, Arnaud Comte, Laurence Hecquet, Franck Charmantray, Bastien Doumèche
Journal: Protein Sci
PubMed ID: 38145310
Doi: 10.1002/pro.4884
Products & Services: Molecular Biology Reagents   
Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition
Authors: Yi-Ting Huang, Ya-Ting Hsu, Pei-Ying Wu, Yu-Min Yeh, Peng-Chan Lin, Keng-Fu Hsu, Meng-Ru Shen
Journal: J Exp Clin Cancer Res
PubMed ID: 38424547
Doi: 10.1186/s13046-024-02987-z
Products & Services: Custom DNA/RNA Oligos   
Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability
Authors: Minhui Ye, Yingzhe Fang, Lu Chen, Zemin Song, Qing Bao, Fei Wang, Hao Huang, Jin Xu, Ziwen Wang, Ruijing Xiao, Meng Han, Song Gao, Hudan Liu, Baishan Jiang, Guoliang Qing
Journal: Nat Commun
PubMed ID: 38493213
Doi: 10.1038/s41467-024-46572-6
Products & Services: Synthetic Guide RNA   
Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations
Authors: Lucas Tricoli, Sunetra Sase, Julia Hacker, Vi Pham, Sidney Smith, Maxwell Chappell, Laura Breda, Stephanie Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Peter Kurre, Rebecca Ahrens-Nicklas, Laura Adang, Adeline Vanderver, Stefano Rivella
Journal: biorxiv
PubMed ID: 38559013
Doi: 10.1101/2024.03.14.584404
Products & Services: Molecular Biology Reagents   
Diverse INOSITOL PHOSPHORYLCERAMIDE SYNTHASE mutant alleles of Physcomitrium patens offer new insight into complex sphingolipid metabolism
Authors: Tegan M Haslam, Cornelia Herrfurth, Ivo Feussner
Journal: New Phytol
PubMed ID: 38523559
Doi: 10.1111/nph.19667
Products & Services: Gene Synthesis   
A SARS-CoV-2 Nanobody Displayed on the Surface of Human Ferritin with High Neutralization Activity
Authors: Wenrong Zhang, Haining Wang, Tong Wu, Xintao Gao, Yuting Shang, Zhifang Zhang, Xingjian Liu, Yinü Li
Journal: International journal of nanomedicine
PubMed ID: 38476285
Doi: 10.2147/IJN.S450829
Products & Services: Molecular Biology Reagents   
A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in
Authors: Shaonil Binti, Adison G Linder, Philip T Edeen, David S Fay
Journal: biorxiv
PubMed ID: 38559252
Doi: 10.1101/2024.03.12.584557
Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats
Authors: Jingjing Zhang, Tao Liu, Yanzhao Wei, Jianye Peng, Gaofeng Zeng, Peng Zhong
Journal: BMC Cardiovasc Disord
PubMed ID: 38539067
Doi: 10.1186/s12872-024-03852-9
Products & Services: Gene Synthesis   
Post-therapeutic cure criterion in chronic Chagas disease using Trypanosoma cruzi chimeric proteins
Authors: Tycha Bianca Sabaini Pavan, Leonardo Maia Leony, Wayner Vieira de Souza, Emily Ferreira Santos, Ramona Tavares Daltro, Natalia Erdens Maron Freitas, Larissa Carvalho Medrado Vasconcelos, Fernanda Lopes Habib, Angelo Antonio Oliveira Silva, Paola Alejandra Fiorani Celedon, Daniel Dias Sampaio, Nilson Ivo Tonin Zanchin, Silvia Andrea Longhi, Fred Luciano Neves Santos
Journal: Folia Parasitol (Praha)
PubMed ID: 38526232
Doi: 10.14411/fp.2024.004
Products & Services: Gene Synthesis   
Extracellular vesicles promote proliferation in an animal model of regeneration
Authors: Priscilla N Avalos, Lily L Wong, David J Forsthoefel
Journal: biorxiv
PubMed ID: 38712279
Doi: 10.1101/2024.03.22.586206
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Tuning Molecular Motion Enhances Intrinsic Fluorescence in Peptide Amphiphile Nanofibers
Authors: Natchayaporn Sindhurattavej, Shreya Jampana, Mai Phuong Pham, Leonardo C Romero, Anna Grace Rogers, Griffin A Stevens, Whitney C Fowler
Journal: Biomacromolecules
PubMed ID: 38508219
Doi: 10.1021/acs.biomac.4c00050
Products & Services: Peptide Synthesis   
Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization
Authors: Dingfeng Li, Xinyi Gao, Xiaolin Ma, Ming Wang, Chuandong Cheng, Tian Xue, Feng Gao, Yong Shen, Juan Zhang, Qiang Liu
Journal: Cell Metab
PubMed ID: 38458203
Doi: 10.1016/j.cmet.2024.02.011.
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Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice
Authors: Yiling Yang, Qinggang Dai, Xin Gao, Yanfei Zhu, Mi Ri Chung, Anting Jin, Yuanqi Liu, Xijun Wang, Xiangru Huang, Siyuan Sun, Hongyuan Xu, Jingyi Liu, Lingyong Jiang
Journal: J Bone Miner Res
PubMed ID: 38477783
Doi: 10.1093/jbmr/zjae032
Products & Services: Protein Electrophoresis and Western   
Transport-controlled growth decoupling for self-induced protein expression with a glycerol-repressible genetic circuit
Authors: Alvaro R Lara, Flavio Kunert, Vincent Vandenbroucke, Hilal Taymaz-Nikerel, Luz María Martínez, Juan-Carlos Sigala, Frank Delvigne, Guillermo Gosset, Jochen Büchs
Journal: Biotechnol Bioeng
PubMed ID: 38470342
Doi: 10.1002/bit.28697
Products & Services: Recombinant Proteins   
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
Authors: Zhixia Song, Yao Xia, Lang Shi, Hongchu Zha, Jing Huang, Xiaohong Xiang, Huiming Li, Hua Huang, Ruchi Yue, Hongtao Wang, Jiefu Zhu
Journal: Cell Mol Biol Lett
PubMed ID: 38439028
Doi: 10.1186/s11658-024-00553-1
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Comprehensive domain-specific analysis and immunoglobulin G profiling of anti-factor VIII antibodies using a bead-based multiplex immunoassay
Authors: Behnaz Pezeshkpoor, Ann-Cristin Berkemeier, Kerstin Herbst, Thilo Albert, Jens Müller, Johannes Oldenburg
Journal: J Thromb Haemost
PubMed ID: 38453023
Doi: 10.1016/j.jtha.2024.02.016
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CERK1 compromises Fusarium solani resistance by reducing jasmonate level and undergoes a negative feedback regulation via the MMK2-WRKY71 module in apple
Authors: Tingting Pei, Minghui Zhan, Dongshan Niu, Yuerong Liu, Jie Deng, Yuanyuan Jing, Pengmin Li, Changhai Liu, Fengwang Ma
Journal: Plant Cell Environ
PubMed ID: 38515330
Doi: 10.1111/pce.14896
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