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Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense

Authors: Rui Cheng , Fengtao Huang , Xueling Lu , Yan Yan , Bingbing Yu , Xionglue Wang , Bin Zhu

Journal: Cell Host Microbe .

PubMed ID: 37480847

Doi: 10.1016/j.chom.2023.06.014

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Targeting CXCR4-expressing Cancer Cells with Avidin-poly (lactic-co-glycolic acid) Nanoparticle Surface Modified with Biotinylated DV1 Peptide

Authors: Shiba Ansari, Madeeha Mudassir, B Vijayalekshmi, Parthaprasad Chattopadhyay

Journal: Int J Appl Basic Med Res

PubMed ID: 37614837

Doi: 10.4103/ijabmr.ijabmr_58_23

Products & Services: Peptide Synthesis

Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results

Authors: Raffit Hassan, Marcus Butler, Roisin E O'Cearbhaill, David Y Oh, Melissa Johnson, Kevin Zikaras, Munisha Smalley, Michael Ross, Janos L Tanyi, Azam Ghafoor, Nirali N Shah, Babak Saboury, Liang Cao, Alfonso Quintás-Cardama, David Hong

Journal: Nat Med

PubMed ID: 37501016

Doi: 10.1038/s41591-023-02452-y

Products & Services: Proteins, Expression, Isolation and Analysis

Monitoring SARS-CoV-2 variants in wastewater of Dhaka City, Bangladesh: approach to complement public health surveillance systems

Authors: Rehnuma Haque, Mohammad Enayet Hossain, Mojnu Miah, Mahbubur Rahman, Nuhu Amin, Ziaur Rahman, Md Shariful Islam, Mohammed Ziaur Rahman

Journal: Hum Genomics

PubMed ID: 37420264

Doi: 10.1186/s40246-023-00505-4

Products & Services: Molecular Biology Reagents

Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins

Authors: Ashley P Viera Ortiz, Gregory Cajka, Olamide A Olatunji, Bailey Mikytuck, Ophir Shalem, Edward B Lee

Journal: Brain

PubMed ID: 36516294

Doi: 10.1093/brain/awac479

Products & Services: DNA Sequencing

Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

Authors: Shiqun Wang , Wei Yan, Lingkai Kong , Shuguang Zuo , Jingyi Wu, Chunxiao Zhu , Huaping Huang , Bohao He, Jie Dong, Jiwu Wei

Journal: Nat Commun .

PubMed ID: 37474548

Doi: 10.1038/s41467-023-39683-z

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Enhanced Carotenoid Production in Chlamydomonas reinhardtii via Overexpression of Endogenous and Exogenous Beta-Carotene Ketolase (BKT) Genes

Authors: Yuanhao Chen , Hong Du , Honghao Liang , Ting Hong , Tangcheng Li

Journal: Int J Mol Sci .

PubMed ID: 37511141

Doi: 1422-0067/24/14/11382

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Perdeuterated GbpA Enables Neutron Scattering Experiments of a Lytic Polysaccharide Monooxygenase

Authors: H V Sørensen, Mateu Montserrat-Canals, Jennifer S M Loose, S Zoë Fisher, Martine Moulin, Matthew P Blakeley, Gabriele Cordara, Kaare Bjerregaard-Andersen, Ute Krengel

Journal: ACS Omega

PubMed ID: 37599915

Doi: 10.1021/acsomega.3c02168

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity and safety of inactivated SARS-CoV-2 vaccine in haemodialysis patients: a prospective cohort study

Authors: Metalia Puspitasari, Prenali D Sattwika, Dzerlina S Rahari, Wynne Wijaya, Auliana R P Hidayat, Nyoman Kertia, Bambang Purwanto, Jarir At Thobari

Journal: Sci Rep

PubMed ID: 37463975

Doi: 10.1038/s41598-023-38628-2

Products & Services: Molecular Biology Reagents

Interspersed expression of CUP-SHAPED COTYLEDON2 and REDUCED COMPLEXITY shapes Cardamine hirsuta complex leaf form

Authors: Neha Bhatia, David Wilson-Sánchez, Sören Strauss, Francesco Vuolo, Bjorn Pieper, Ziliang Hu, Léa Rambaud-Lavigne, Miltos Tsiantis

Journal: Curr Biol

PubMed ID: 37453425

Doi: 10.1016/j.cub.2023.06.037

Products & Services: Molecular Biology Reagents

A deep learning-based drug repurposing screening and validation for anti-SARS-CoV-2 compounds by targeting the cell entry mechanism

Authors: Yingjia Yao, Yunhan Zhang, Zexu Li, Zhisong Chen, Xiaofeng Wang, Zihan Li, Li Yu, Xiaolong Cheng, Wei Li, Wen-Jie Jiang, Hua-Jun Wu, Zezhong Feng, Jinfu Sun, Teng Fei

Journal: Biochem Biophys Res Commun

PubMed ID: 37467664

Doi: 10.1016/j.bbrc.2023.07.018

Products & Services: Molecular Biology Reagents

Purification and characterization of human glycerol 3-phosphate dehydrogenases (mitochondrial and cytosolic) by NAD/NADH redox method

Authors: Superior Syngkli, Bidyadhar Das

Journal: Biochimie

PubMed ID: 37481063

Doi: 10.1016/j.biochi.2023.07.015

Products & Services: Molecular Biology Reagents

N6-Methyladenosine Promotes Translation of VEGFA to Accelerate Angiogenesis in Lung Cancer

Authors: Haisheng Zhang, Jiawang Zhou, Jiexin Li, Zhaotong Wang, Zhuojia Chen, Ziyan Lv, Lichen Ge, Guoyou Xie, Guoming Deng, Yalan Rui, Hongbing Huang, Likun Chen, Hongsheng Wang

Journal: Cancer Res

PubMed ID: 37103476

Doi: 10.1158/0008-5472.CAN-22-2449

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Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1

Authors: Eva-Maria Thüring, Christian Hartmann, Janesha C Maddumage, Airah Javorsky, Birgitta E Michels, Volker Gerke, Lawrence Banks, Patrick O Humbert, Marc Kvansakul, Klaus Ebnet

Journal: Commun Biol

PubMed ID: 37430142

Doi: 10.1038/s42003-023-05088-3

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Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins

Authors: Haolan Wang , Ming Guo , Hudie Wei , Yongheng Chen

Journal: Comput Struct Biotechnol J .

PubMed ID: 37560128

Doi: 10.1016/j.csbj.2023.07.017

Products & Services: Peptide Synthesis

The combined action of the intracellular regions regulates FGFR2 kinase activity

Authors: Chi-Chuan Lin , Lukasz Wieteska , Guillaume Poncet-Montange , Kin Man Suen , Stefan T Arold , Zamal Ahmed , John E Ladbury

Journal: Commun Biol .

PubMed ID: 37452126

Doi: 10.1038/s42003-023-05112-6

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Development of miniature base editors using engineered IscB nickase

Authors: Dingyi Han , Qingquan Xiao , Yifan Wang , Hainan Zhang , Xue Dong , Guoling Li , Xiangfeng Kong , Shihao Wang , Jinhui Song , Weihong Zhang , Jingxing Zhou , Lanting Bi , Yuan Yuan , Linyu Shi , Na Zhong , Hui Yang , Yingsi Zhou

Journal: Nat Methods .

PubMed ID: 37231266

Doi: 10.1038/s41592-023-01898-9

Products & Services: Gene Synthesis

Manganese-based microcrystals equipped with Ythdf1-targeted biomimeticnanovaccines for reinforced dendritic cell spatiotemporal orchestration

Authors: Feng Liu , Lulu Tan, Zheng Dai , Yang Wang , Lei Huang , Yang Zhang , Qian Cheng , Xin Li , Miao-Deng Liu, Lin Wang, Zheng Wang

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102112

Products & Services: DNA Sequencing

Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration

Authors: Xian Xie ， Zhuo Li , Xuefeng Yang , Boguang Yang , Zhixian Zong , Xuemei Wang , Liting Duan , Sien Lin , Gang Li , Liming Bian

Journal: J Am Chem Soc

PubMed ID: 37428960

Doi: 10.1021/jacs.3c02210

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Construction and characterization of a novel miniaturized filamentous phagemid for targeted mammalian gene transfer

Authors: Shirley Wong, Salma Jimenez, Roderick A Slavcev

Journal: Microb Cell Fact

PubMed ID: 37430278

Doi: 10.1186/s12934-023-02135-w

Products & Services: Proteins, Expression, Isolation and Analysis

Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants

Authors: Ebene R Haycroft, Samantha K Davis, Pradhipa Ramanathan, Ester Lopez, Ruth A Purcell, Li Lynn Tan, Phillip Pymm, Bruce D Wines, P Mark Hogarth, Adam K Wheatley, Jennifer A Juno, Samuel J Redmond, Nicholas A Gherardin, Dale I Godfrey, Wai-Hong Tham, Kevin John Selva, Stephen J Kent, Amy W Chung

Journal: Med Microbiol Immunol

PubMed ID: 37477828

Doi: 10.1007/s00430-023-00773-w

Products & Services: Proteins, Expression, Isolation and Analysis

Effectors of the Type VI Secretion System Have the Potential to Be Modified into Antimicrobial Peptides

Authors: Wenjia Lu, Hao Lu, Chenchen Wang, Gaoyan Wang, Wenqi Dong, Chen Tan

Journal: Microbiol Spectr

PubMed ID: 37470717

Doi: 10.1128/spectrum.00308-23

Products & Services: Peptide Synthesis

Fusion of Substrate-Binding Domains Enhances the Catalytic Capacity of Keratinases and Promotes Enzymatic Conversion of Feather Waste

Authors: Xiaomei Ji, Zheng Peng, Jie Song, Guoqiang Zhang, Juan Zhang

Journal: J Agric Food Chem

PubMed ID: 37462367

Doi: 10.1021/acs.jafc.3c03064

Products & Services: Proteins, Expression, Isolation and Analysis

Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G

Authors: Takahide Kouno, Satoshi Shibata, Megumi Shigematsu, Jaekyung Hyun, Tae Gyun Kim, Hiroshi Matsuo, Matthias Wolf

Journal: Nat Commun

PubMed ID: 37419875

Doi: 10.1038/s41467-023-39796-5

Products & Services: Proteins, Expression, Isolation and Analysis

An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles

Authors: Huanhuan Li, Yixi Wu, Minke Li, Lu Guo, Yaqi Gao, Quan Wang, Jihua Zhang, Zhaohua Lai, Xing Zhang, Lixin Zhu, Ping Lan, Zihe Rao, Yingfang Liu, Huanhuan Liang

Journal: Nat Struct Mol Biol

PubMed ID: 37488357

Doi: 10.1038/s41594-023-01043-2

Products & Services: Proteins, Expression, Isolation and Analysis

Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Authors: Jay C Groppe, Guorong Lu, Mary R Tandang-Silvas, Anupama Pathi, Shruti Konda, Jingfeng Wu, Viet Q Le, Andria L Culbert, Eileen M Shore, Kristi A Wharton, Frederick S Kaplan

Journal: Biomolecules

PubMed ID: 37509165

Doi: 10.3390/biom13071129

Products & Services: Proteins, Expression, Isolation and Analysis

Tumor Site-Specific Cleavage Improves the Antitumor Efficacy of Antibody-Drug Conjugates

Authors: Keyuan Xu, Jiani Han, Liu Yang, Li Cao, Shuang Li, Zhangyong Hong

Journal: Int J Mol Sci

PubMed ID: 37446189

Doi: 10.3390/ijms241311011

Products & Services: Proteins, Expression, Isolation and Analysis

Peptide/Nanoparticle Biointerfaces for Multistep Tandem Catalysis

Authors: Yuliana Perdomo, Joseph M Slocik, David M Phillips, Marc R Knecht

Journal: J Am Chem Soc

PubMed ID: 37478168

Doi: 10.1021/jacs.3c04097

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Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment

Authors: Derek Allen, Samerender Nagam Hanumantharao, Rylie McDonell, Karen-Amanda Irvine, Peyman Sahbaie, David Clark, Paul Blum

Journal: Sci Rep

PubMed ID: 37479740

Doi: 10.1038/s41598-023-38618-4

Products & Services: Proteins, Expression, Isolation and Analysis

Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays

Authors: So Jin Bing, Stephanee Warrington, Ronit Mazor

Journal: Front Immunol

PubMed ID: 37469509

Doi: 10.3389/fimmu.2023.1211529

Products & Services: Proteins, Expression, Isolation and Analysis

RNA m5C methylation orchestrates BLCA progression via macrophage reprogramming

Authors: Dali Yan, Yongsong Xie, Liyuan Huang, Yi Zhang, Runhuan Gu, Huaibing Xie, Xing Huang, Hao Luo

Journal: J Cell Mol Med

PubMed ID: 37408139

Doi: 10.1111/jcmm.17826

Products & Services: Proteins, Expression, Isolation and Analysis

Hypoxic papillary thyroid carcinoma cells-secreted exosomes deliver miR-221-3p to normoxic tumor cells to elicit a pro-tumoral effect by regulating the ZFAND5

Authors: Fan Yu, Xianzhao Deng, Yong Zhong, Bomin Guo, Xiaoping Zhang, Bo Wu

Journal: Exp Cell Res

PubMed ID: 37488006

Doi: 10.1016/j.yexcr.2023.113716

Products & Services: Proteins, Expression, Isolation and Analysis

Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola

Authors: Feng Wang, Chendi Zhang, Haijiang Xu, Wanting Zeng, Lixin Ma, Zhuang Li

Journal: J Mol Biol

PubMed ID: 37442412

Doi: 10.1016/j.jmb.2023.168197

Products & Services: Proteins, Expression, Isolation and Analysis

Activation of PDGF Signaling in the Adult Muscle Stem Cell Niche in Patients With Type 2 Diabetes Mellitus

Authors: Alexandra Fahrner, Nikoleta Alchus Laiferová, Barbara Ukropcová, Jozef Ukropec, Jan Krützfeldt

Journal: J Clin Endocrinol Metab

PubMed ID: 36702759

Doi: 10.1210/clinem/dgad041

Products & Services: Proteins, Expression, Isolation and Analysis

Integrated immunoinformatics and subtractive proteomics approach for multi-epitope vaccine designing to combat TIGR4

Authors: Sami S Ashgar, Hani Faidah, Farkad Bantun, Naif A Jalal, Naeem F Qusty, Abdulla Darwish, Shafiul Haque, Essam M Janahi

Journal: Front Mol Biosci

PubMed ID: 37560463

Doi: 10.3389/fmolb.2023.1212119

Products & Services: Proteins, Expression, Isolation and Analysis

Long Non-coding RNA LINC00342 Promotes the Proliferation, Invasion, and Migration of Primary Hepatocellular Carcinoma Cells by Regulating the Expression of miRNA-19a-3p, miRNA-545-5p, and miRNA-203a-3p

Authors: Zong-Xi Yao, Jun-Hao Tu, Yu-Lin Liu, Xiao-Feng Xue, Lei Qin

Journal: Biochem Genet

PubMed ID: 37395850

Doi: 10.1007/s10528-023-10420-x

Products & Services: Proteins, Expression, Isolation and Analysis

A bistable autoregulatory module in the developing embryo commits cells to binary expression fates

Authors: Jiaxi Zhao, Mindy Liu Perkins, Matthew Norstad, Hernan G Garcia

Journal: Curr Biol

PubMed ID: 37453424

Doi: 10.1016/j.cub.2023.06.060

Products & Services: Proteins, Expression, Isolation and Analysis

Generation of Bioactive Peptides from sp and Assessment of Their Potential for Use in the Prevention of Hypertension, Inflammation and Pain

Authors: Maria Hayes, Rotimi E Aluko, Elena Aurino, Leticia Mora

Journal: Mar Drugs

PubMed ID: 37623703

Doi: 10.3390/md21080422

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TLR5S negatively regulates the TLR5M-mediated NF-κB signaling pathway in Epinephelus coioides

Authors: Liangge He, Xue Yu, Yulin Zhao, Haoran Lin, Yong Zhang, Danqi Lu

Journal: Int J Biol Macromol

PubMed ID: 37517756

Doi: 10.1016/j.ijbiomac.2023.126048

Products & Services: Proteins, Expression, Isolation and Analysis

Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays

Authors: Rui Qing, Mantian Xue, Jiayuan Zhao, Lidong Wu, Andreas Breitwieser, Eva Smorodina, Thomas Schubert, Giovanni Azzellino, David Jin, Jing Kong, Tomás Palacios, Uwe B Sleytr, Shuguang Zhang

Journal: Sci Adv

PubMed ID: 37478177

Doi: 10.1126/sciadv.adf1402

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An integrated genomic approach identifies follistatin as a target of the p63-epidermal growth factor receptor oncogenic network in head and neck squamous cell carcinoma

Authors: Akinsola Oyelakin, Jennifer Sosa, Kasturi Bala Nayak, Alexandra Glathar, Christian Gluck, Isha Sethi, Maria Tsompana, Norma Nowak, Michael Buck, Rose-Anne Romano, Satrajit Sinha

Journal: NAR Cancer

PubMed ID: 37492374

Doi: 10.1093/narcan/zcad038

Products & Services: Plasmid DNA Preparation

Author Correction: A pan-influenza antibody inhibiting neuraminidase via receptor mimicry

Authors: Corey Momont, Ha V Dang, Fabrizia Zatta, Kevin Hauser, Caihong Wang, Julia di Iulio, Andrea Minola, Nadine Czudnochowski, Anna De Marco, Kaitlin Branch, David Donermeyer, Siddhant Vyas, Alex Chen, Elena Ferri, Barbara Guarino, Abigail E Powell, Roberto Spreafico, Samantha S Yim, Dale R Balce, Istvan Bartha, Marcel Meury, Tristan I Croll, David M Belnap, Michael A Schmid, William Timothy Schaiff, Jessica L Miller, Elisabetta Cameroni, Amalio Telenti, Herbert W Virgin, Laura E Rosen, Lisa A Purcell, Antonio Lanzavecchia, Gyorgy Snell, Davide Corti, Matteo Samuele Pizzuto

Journal: Nature

PubMed ID: 37407829

Doi: 10.1038/s41586-023-06385-x

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Systemic delivery of specific and efficient CRISPR/Cas9 system targeting HPV16 oncogenes using LL-37 antimicrobial peptide in C57BL/6 mice

Authors: Niloofar Khairkhah, Azam Bolhassani, Farzad Rajaei, Reza Najafipour

Journal: J Med Virol

PubMed ID: 37403986

Doi: 10.1002/jmv.28934

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A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury

Authors: Chen Yang, Huidie Xu, Dong Yang, Yunhao Xie, Mingrui Xiong, Yu Fan, XiKai Liu, Yu Zhang, Yushuo Xiao, Yuchen Chen, Yihao Zhou, Liangliang Song, Chen Wang, Anlin Peng, Robert B Petersen, Hong Chen, Kun Huang, Ling Zheng

Journal: Nat Commun

PubMed ID: 37460623

Doi: 10.1038/s41467-023-40036-z

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Ice Recrystallization Inhibition Activity of Soy Protein Hydrolysates

Authors: Madison Fomich, Vermont P Día, Uvinduni I Premadasa, Benjamin Doughty, Hari B Krishnan, Tong Wang

Journal: J Agric Food Chem

PubMed ID: 37466256

Doi: 10.1021/acs.jafc.2c08701

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptomic analysis of hepatocytes reveals the association between ubiquitin-specific peptidase 1 and yes-associated protein 1 during liver regeneration

Authors: Yalei Zhao, Fen Zhang, Xiaoli Zhang, Zuhong Li, Qian Li, Tianzhi Ni, Ruojing Wang, Liangru Liu, Yingli He, Yingren Zhao

Journal: Regen Ther

PubMed ID: 37534236

Doi: 10.1016/j.reth.2023.07.004

Products & Services: Molecular Biology Reagents

The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization

Authors: Melissa S Traver , Bonnie Bartel

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 37410814

Doi: 10.1073/pnas.2304870120

Products & Services: Gene Synthesis

Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Authors: Hudie Wei , Haolan Wang , Genxin Wang , Lingzhi Qu , Longying Jiang , Shuyan Dai , Xiaojuan Chen , Ye Zhang , Zhuchu Chen , Youjun Li , Ming Guo , Yongheng Chen

Journal: Nat Commun .

PubMed ID: 37463921

Doi: 10.1038/s41467-023-40087-2

Products & Services: Proteins, Expression, Isolation and Analysis

Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer

Authors: Apostolia M Tsimberidou, Kerstin Guenther, Borje S Andersson, Regina Mendrzyk, Amir Alpert, Claudia Wagner, Anna Nowak, Katrin Aslan, Arun Satelli, Fabian Richter, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Zoe Coughlin, Ali S Mohamed, Kerry Sieger, Becky Norris, Rita Ort, Jennifer Beck, Henry Hiep Vo, Franziska Hoffgaard, Manuel Ruh, Linus Backert, Ignacio I Wistuba, David Fuhrmann, Nuhad K Ibrahim, Van Karlyle Morris, Bryan K Kee, Daniel M Halperin, Graciela M Nogueras-Gonzalez, Partow Kebriaei, Elizabeth J Shpall, David Vining, Patrick Hwu, Harpreet Singh, Carsten Reinhardt, Cedrik M Britten, Norbert Hilf, Toni Weinschenk, Dominik Maurer, Steffen Walter

Journal: Cancer Immunol Res

PubMed ID: 37172100

Doi: 10.1158/2326-6066.CIR-22-0444

Products & Services: Proteins, Expression, Isolation and Analysis

Protein oxidation increases SAMHD1 binding ssDNA via its regulatory site

Authors: Theresa L Simermeyer, Stephanie Batalis, LeAnn C Rogers, Owen J Zalesak, Thomas Hollis

Journal: Nucleic Acids Res

PubMed ID: 37246644

Doi: 10.1093/nar/gkad447

Products & Services: Proteins, Expression, Isolation and Analysis

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