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Oral Delivery of Novel Recombinant Elicit High Protection against Pulmonary and Skin Infections

Authors: Na Pan, Bohui Liu, Xuemei Bao, Haochi Zhang, Shouxin Sheng, Yanchen Liang, Haiting Pan, Xiao Wang

Journal: Vaccines (Basel)

PubMed ID: 34579221

Doi: 10.3390/vaccines9090984

Products & Services: Codon Optimization

Metabolic engineering of Deinococcus radiodurans for pinene production from glycerol

Authors: Seyed Hossein Helalat, Carsten Jers, Mandana Bebahani, Hassan Mohabatkar, Ivan Mijakovic

Journal: Microb Cell Fact

PubMed ID: 34565367

Doi: 10.1186/s12934-021-01674-4

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COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models

Authors: Antonella Conforti, Emanuele Marra, Fabio Palombo, Giuseppe Roscilli, Micol Ravà, Valeria Fumagalli, Alessia Muzi, Mariano Maffei, Laura Luberto, Lucia Lione, Erika Salvatori, Mirco Compagnone, Eleonora Pinto, Emiliano Pavoni, Federica Bucci, Grazia Vitagliano, Daniela Stoppoloni, Maria Lucrezia Pacello, Manuela Cappelletti, Fabiana Fosca Ferrara, Emanuela D'Acunto, Valerio Chiarini, Roberto Arriga, Abraham Nyska, Pietro Di Lucia, Davide Marotta, Elisa Bono, Leonardo Giustini, Eleonora Sala, Chiara Perucchini, Jemma Paterson, Kathryn Ann Ryan, Amy-Rose Challis, Giulia Matusali, Francesca Colavita, Gianfranco Caselli, Elena Criscuolo, Nicola Clementi, Nicasio Mancini, Rüdiger Groß, Alina Seidel, Lukas Wettstein, Jan Münch, Lorena Donnici, Matteo Conti, Raffaele De Francesco, Mirela Kuka, Gennaro Ciliberto, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Luca G Guidotti, Lucio Rovati, Matteo Iannacone, Luigi Aurisicchio

Journal: Mol Ther

PubMed ID: 34547465

Doi: 10.1016/j.ymthe.2021.09.011

Products & Services: Codon Optimization

Bispecific Antibody Designed for Targeted NK Cell Activation and Functional Assessment for Biomedical Applications

Authors: Ah-Young Song, Hyori Kim, Jung Min Kim, Sang-Hyun Hwang, Dae-Hyun Ko, Hun Sik Kim

Journal: ACS Appl Mater Interfaces

PubMed ID: 34486371

Doi: 10.1021/acsami.1c08986

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Neuropeptide repertoire and 3D anatomy of the ctenophore nervous system

Authors: Maria Y Sachkova, Eva-Lena Nordmann, Joan J Soto-Àngel, Yasmin Meeda, Bartłomiej Górski, Benjamin Naumann, Daniel Dondorp, Marios Chatzigeorgiou, Maike Kittelmann, Pawel Burkhardt

Journal: Curr Biol

PubMed ID: 34587474

Doi: 10.1016/j.cub.2021.09.005

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Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers

Authors: Tsuguhisa Nakayama, Ivan T Lee, Sizun Jiang, Matthias S Matter, Carol H Yan, Jonathan B Overdevest, Chien-Ting Wu, Yury Goltsev, Liang-Chun Shih, Chun-Kang Liao, Bokai Zhu, Yunhao Bai, Peter Lidsky, Yinghong Xiao, David Zarabanda, Angela Yang, Meena Easwaran, Christian M Schürch, Pauline Chu, Han Chen, Anna K Stalder, David R McIlwain, Nicole A Borchard, Phillip A Gall, Sachi S Dholakia, Wei Le, Le Xu, Chih-Jaan Tai, Te-Huei Yeh, Elizabeth Erickson-Direnzo, Jason M Duran, Kirsten D Mertz, Peter H Hwang, Jasmin D Haslbauer, Peter K Jackson, Thomas Menter, Raul Andino, Peter D Canoll, Adam S DeConde, Zara M Patel, Alexandar Tzankov, Garry P Nolan, Jayakar V Nayak

Journal: Cell Rep Med

PubMed ID: 34604819

Doi: 10.1016/j.xcrm.2021.100421

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Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion

Authors: Jana Škerlová, Jens Berndtsson, Hendrik Nolte, Martin Ott, Pål Stenmark

Journal: Nat Commun

PubMed ID: 34489474

Doi: 10.1038/s41467-021-25570-y

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Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex

Authors: Xi Liu, Laixing Zhang, Yu Xiu, Teng Gao, Ling Huang, Yongchao Xie, Lingguang Yang, Wenhe Wang, Peiyi Wang, Yi Zhang, Maojun Yang, Yue Feng

Journal: Nucleic Acids Res

PubMed ID: 34432044

Doi: 10.1093/nar/gkab738

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Engineering high coenzyme Q tomato

Authors: Hang Fan, Yan Liu, Chen-Yi Li, Yan Jiang, Jiao-Jiao Song, Lei Yang, Qing Zhao, Yong-Hong Hu, Xiao-Ya Chen, Jing-Jing Xu

Journal: Metab Eng

PubMed ID: 34555495

Doi: 10.1016/j.ymben.2021.09.007

Products & Services: Bacterial Expression

Structural and Kinetic Insights Into the Molecular Basis of Salt Tolerance of the Short-Chain Glucose-6-Phosphate Dehydrogenase From

Authors: Nicolás Fuentes-Ugarte, Sixto M Herrera, Pablo Maturana, Victor Castro-Fernandez, Victoria Guixé

Journal: Front Microbiol

PubMed ID: 34650535

Doi: 10.3389/fmicb.2021.730429

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Azurocidin is loaded into small extracellular vesicles via its N-linked glycosylation and promotes intravasation of renal cell carcinoma cells

Authors: Takuya Naito, Kentaro Jingushi, Koji Ueda, Kazutake Tsujikawa

Journal: FEBS Lett

PubMed ID: 34418081

Doi: 10.1002/1873-3468.14183

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The immunogenomic landscape of resected intrahepatic cholangiocarcinoma

Authors: Fernando Carapeto, Behnaz Bozorgui, Rachna T Shroff, Sharmeen Chagani, Luisa Solis Soto, Wai Chin Foo, Ignacio Wistuba, Funda Meric-Bernstam, Ahmed Shalaby, Milind Javle, Anil Korkut, Lawrence N Kwong

Journal: Hepatology

PubMed ID: 34510503

Doi: 10.1002/hep.32150

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CG Dinucleotide Removal in Bioluminescent and Fluorescent Reporters Improves HIV-1 Replication and Reporter Gene Expression for Dual Imaging in Humanized Mice

Authors: Chandra N Roy, Mariana A Benitez Moreno, Chris Kline, Zandrea Ambrose

Journal: J Virol

PubMed ID: 34232063

Doi: 10.1128/JVI.00449-21

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Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition

Authors: Jiaqi Chen, Qiaoya Pan, Yang Bai, Xuepeng Chen, Yi Zhou

Journal: Front Mol Biosci

PubMed ID: 34568426

Doi: 10.3389/fmolb.2021.720370

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Corrigendum: Reductive Power Generated by Through Cholesterol Oxidation Contributes to Lipid and ATP Synthesis

Authors: Thabatta L S A Rosa, Maria Angela M Marques, Zachary DeBoard, Kelly Hutchins, Carlos Adriano A Silva, Christine R Montague, Tianao Yuan, Julio J Amaral, Georgia C Atella, Patrícia S Rosa, Katherine A Mattos, Brian C VanderVen, Ramanuj Lahiri, Nicole S Sampson, Patrick J Brennan, John T Belisle, Maria Cristina V Pessolani, Marcia Berrêdo-Pinho

Journal: Front Cell Infect Microbiol

PubMed ID: 34650934

Doi: 10.3389/fcimb.2021.765326

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A Novel TLR4-Binding Domain of Peroxiredoxin From Triggers NLRP3 Inflammasome Activation in Macrophages

Authors: Xia Li, Meng Feng, Yanqing Zhao, Yuhan Zhang, Ruixue Zhou, Hang Zhou, Zhen Pang, Hiroshi Tachibana, Xunjia Cheng

Journal: Front Immunol

PubMed ID: 34659265

Doi: 10.3389/fimmu.2021.758451

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Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

Authors: Qiufeng Liu, Dehua Yang, Youwen Zhuang, Tristan I Croll, Xiaoqing Cai, Antao Dai, Xinheng He, Jia Duan, Wanchao Yin , Chenyu Ye, Fulai Zhou, Beili Wu, Qiang Zhao, H Eric Xu, Ming-Wei Wang, Yi Jiang

Journal: Nat Chem Biol.

PubMed ID: 34556862

Doi: 10.1038/s41589-021-00841-3

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Human cytomegalovirus expands a CD8+ T cell population with loss of BCL11B expression and gain of NK cell identity

Authors: Rosa Sottile, M Kazim Panjwani, Colleen M Lau, Anthony F Daniyan, Kento Tanaka, Juliet N Barker, Renier J Brentjens, Joseph C Sun, Jean-Benoît Le Luduec, Katharine C Hsu

Journal: Sci Immunol

PubMed ID: 34559552

Doi: 10.1126/sciimmunol.abe6968

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Combining spike- and nucleocapsid-based vaccines improves distal control of SARS-CoV-2

Authors: Tanushree Dangi, Jacob Class, Nicole Palacio, Justin M Richner, Pablo Penaloza MacMaster

Journal: Cell Rep

PubMed ID: 34450033

Doi: 10.1016/j.celrep.2021.109664

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The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation

Authors: Izzy Owen, Debra Yee, Hala Wyne, Theodora Myrto Perdikari, Victoria Johnson, Jeremy Smyth, Robert Kortum, Nicolas L Fawzi, Frank Shewmaker

Journal: J Cell Sci

PubMed ID: 34357401

Doi: 10.1242/jcs.258578

Products & Services: Protein Electrophoresis and Western

Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals

Authors: Anthony T Tan, Joey Me Lim, Nina Le Bert, Kamini Kunasegaran, Adeline Chia, Martin Dc Qui, Nicole Tan, Wan Ni Chia, Ruklanthi de Alwis, Ding Ying, Jean Xy Sim, Eng Eong Ooi, Lin-Fa Wang, Mark I-Cheng Chen, Barnaby E Young, Li Yang Hsu, Jenny Gh Low, David C Lye, Antonio Bertoletti

Journal: J Clin Invest

PubMed ID: 34623327

Doi: 10.1172/JCI152379

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Structural basis for the specificity of PPM1H phosphatase for Rab GTPases

Authors: Dieter Waschbüsch, Kerryn Berndsen, Pawel Lis, Axel Knebel, Yuko Py Lam, Dario R Alessi, Amir R Khan

Journal: EMBO Rep

PubMed ID: 34580980

Doi: 10.15252/embr.202152675

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Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection

Authors: Chao Ye, Weiran Li, Ying Yang, Qingwen Liu, Sijing Li, Peng Zheng, Xiao Zheng, Ye Zhang, Jinrong He, Yongjun Chen, Liangqun Hua, Zhongqian Yang, Duo Li, Zhaoling Ren, Ying Yang, Jialong Qi, Weiwei Huang, Yanbing Ma

Journal: Cell Rep

PubMed ID: 34551309

Doi: 10.1016/j.celrep.2021.109750

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Production and Purification of Two Bioactive Antimicrobial Peptides Using a Two-Step Approach Involving an Elastin-Like Fusion Tag

Authors: Ana Margarida Pereira, André da Costa, Simoni Campos Dias, Margarida Casal, Raul Machado

Journal: Pharmaceuticals (Basel)

PubMed ID: 34681180

Doi: 10.3390/ph14100956

Products & Services: Gene Synthesis

Differential MMP-14 Targeting by Lumican-Derived Peptides Unraveled by In Silico Approach

Authors: Jonathan Dauvé, Nicolas Belloy, Romain Rivet, Nicolas Etique, Pierre Nizet, Katarzyna Pietraszek-Gremplewicz, Konstantina Karamanou, Manuel Dauchez, Laurent Ramont, Stéphane Brézillon, Stéphanie Baud

Journal: Cancers (Basel)

PubMed ID: 34638415

Doi: 10.3390/cancers13194930

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Titanium Wear Particles Exacerbate -Induced Implant-Related Osteolysis and Decrease Efficacy of Antibiotic Therapy

Authors: Claudia Siverino, Linda Freitag, Daniel Arens, Ursula Styger, R Geoff Richards, T Fintan Moriarty, Vincent A Stadelmann, Keith Thompson

Journal: Microorganisms

PubMed ID: 34576840

Doi: 10.3390/microorganisms9091945

Products & Services: Protein and Antibody Isolation

Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition

Authors: Chelsie A Kadgien, Anusha Kamesh, Austen J Milnerwood

Journal: Mol Brain

PubMed ID: 34530877

Doi: 10.1186/s13041-021-00848-w

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Multiplex genome editing in using Mb3Cas12a

Authors: William T Jordan, Seth Currie, Robert J Schmitz

Journal: Plant Direct

PubMed ID: 34514290

Doi: 10.1002/pld3.344

Products & Services: ORF cDNA Clones/MolecularCloud

A Secreted Chorismate Mutase from pv Attenuates Virulence and Walnut Blight Symptoms

Authors: Renata de A B Assis, Cíntia H D Sagawa, Paulo A Zaini, Houston J Saxe, Phillip A Wilmarth, Brett S Phinney, Michelle Salemi, Leandro M Moreira, Abhaya M Dandekar

Journal: Int J Mol Sci

PubMed ID: 34638715

Doi: 10.3390/ijms221910374

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SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia

Authors: Yiliang Wei, Yu-Han Huang, Damianos S Skopelitis, Shruti V Iyer, Ana S H Costa, Zhaolin Yang, Melissa Kramer, Emmalee R Adelman, Olaf Klingbeil, Osama E Demerdash, Sofya A Polyanskaya, Kenneth Chang, Sara Goodwin, Emily Hodges, W Richard McCombie, Maria E Figueroa, Christopher R Vakoc

Journal: Cancer Discov

PubMed ID: 34531253

Doi: 10.1158/2159-8290.CD-20-1849

Products & Services: Gene Synthesis

Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

Authors: Silvia Leon, Rajae Talbi, Elizabeth A McCarthy, Kaitlin Ferrari, Chrysanthi Fergani, Lydie Naule, Ji Hae Choi, Rona S Carroll, Ursula B Kaiser, Carlos F Aylwin, Alejandro Lomniczi, Víctor M Navarro

Journal: Elife

PubMed ID: 34494548

Doi: 10.7554/eLife.69765

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Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells

Authors: Cesar L Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer A N Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M Jones, Alejandra A Covarrubias, Shahar Sukenik, José R Dinneny

Journal: Nat Commun

PubMed ID: 34521831

Doi: 10.1038/s41467-021-25736-8

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CriTER-A: A Novel Temperature-Dependent Noncoding RNA Switch in the Telomeric Transcriptome of

Authors: Cristina Romero-López, Alfredo Berzal-Herranz, José Luis Martínez-Guitarte, Mercedes de la Fuente

Journal: Int J Mol Sci

PubMed ID: 34638651

Doi: 10.3390/ijms221910310

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CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner

Authors: Mohammad Golam Sabbir, Carla G Taylor, Peter Zahradka

Journal: Cell Commun Signal

PubMed ID: 34563205

Doi: 10.1186/s12964-021-00778-z

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Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia

Authors: Weiyi Wang, Shuaitong Liu, Peihong Dai, Ning Yang, Yi Wang, Rachel A Giese, Taha Merghoub, Jedd Wolchok, Liang Deng

Journal: J Immunother Cancer

PubMed ID: 34593618

Doi: 10.1136/jitc-2021-002569

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Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

Authors: Jaime L Chao, Michael Korzinkin, Alex Zhavoronkov, Ivan V Ozerov, Matthew T Walker, Kathleen Higgins, Mark W Lingen, Evgeny Izumchenko, Peter A Savage

Journal: Cell Rep Med

PubMed ID: 34622236

Doi: 10.1016/j.xcrm.2021.100399

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A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis

Authors: Jie Zheng, Lu Yao, Yijing Zhou, Xiaoqun Gu, Can Wang, Kaifan Bao, Yang Sun, Min Hong

Journal: Cell Death Dis

PubMed ID: 34561424

Doi: 10.1038/s41419-021-04159-9

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Altered metabolomic states elicited by Flg22 and FlgII-28 in Solanum lycopersicum: intracellular perturbations and metabolite defenses

Authors: Dylan R Zeiss, Paul A Steenkamp, Lizelle A Piater, Ian A Dubery

Journal: BMC Plant Biol

PubMed ID: 34548030

Doi: 10.1186/s12870-021-03200-5

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Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and Alzheimer's Disease in Amyloid Precursor Protein/Presenilin 1 Mice

Authors: Qing Zeng, Qin Fang, Xincai Zhou, Hongfa Yang, Yang Dou, Wenhao Zhang, Pu Gong, Xianfang Rong

Journal: Front Mol Neurosci

PubMed ID: 34658785

Doi: 10.3389/fnmol.2021.728184

Products & Services: Recombinant Proteins

Next-Generation Sequencing Reveals Four Novel Viruses Associated with Calf Diarrhea

Authors: Qi Wu, Jizong Li, Wei Wang, Jinzhu Zhou, Dandan Wang, Baochao Fan, Xuehan Zhang, Dongbo Sun, Ga Gong, Sizhu Suolang, Bin Li

Journal: Viruses

PubMed ID: 34696337

Doi: 10.3390/v13101907

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Identification of Optimal Expression Parameters and Purification of a Codon-Optimized Human GLIS1 Transcription Factor from Escherichia coli

Authors: Chandrima Dey, Vishalini Venkatesan, Rajkumar P Thummer

Journal: Mol Biotechnol

PubMed ID: 34528219

Doi: 10.1007/s12033-021-00390-z

Products & Services: Codon Optimization

Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

Authors: Yilin Pang, Guoqiang Tan, Xunjun Yang, Yuanshan Lin, Yao Chen, Jinping Zhang, Ting Xie, Huaibin Zhou, Jun Fang, Qiongya Zhao, Xiaojun Ren, Jianghui Li, Jianxin Lyu, Zheng Wang

Journal: Cancer Cell Int

PubMed ID: 34488769

Doi: 10.1186/s12935-021-02131-3

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Kinetic Characterization of a Putatively Chitin-Active LPMO Reveals a Preference for Soluble Substrates and Absence of Monooxygenase Activity

Authors: Lukas Rieder, Dejan Petrović, Priit Väljamäe, Vincent G H Eijsink, Morten Sørlie

Journal: ACS Catal

PubMed ID: 34567832

Doi: 10.1021/acscatal.1c03344

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Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation

Authors: Huan-Li Yang, Xiao-Wu Shi

Journal: Front Neurol

PubMed ID: 34557140

Doi: 10.3389/fneur.2021.659678

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Epitope Profiling Reveals the Critical Antigenic Determinants in SARS-CoV-2 RBD-Based Antigen

Authors: Min Jiang, Gaiping Zhang, Hongliang Liu, Peiyang Ding, Yunchao Liu, Yuanyuan Tian, Yanwei Wang, Aiping Wang

Journal: Front Immunol

PubMed ID: 34621266

Doi: 10.3389/fimmu.2021.707977

Products & Services: Recombinant Proteins

Perturbation-specific responses by two neural circuits generating similar activity patterns

Authors: Daniel J Powell, Eve Marder, Michael P Nusbaum

Journal: Curr Biol

PubMed ID: 34506730

Doi: 10.1016/j.cub.2021.08.042

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A Molecular Survey of Bacterial Species in the Guts of Black Soldier Fly Larvae () Reared on Two Urban Organic Waste Streams in Kenya

Authors: Marwa Shumo, Fathiya M Khamis, Fidelis Levi Ombura, Chrysantus M Tanga, Komi K M Fiaboe, Sevgan Subramanian, Sunday Ekesi, Oliver K Schlüter, Arnold van Huis, Christian Borgemeister

Journal: Front Microbiol

PubMed ID: 34630342

Doi: 10.3389/fmicb.2021.687103

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SARS-CoV-2 Antibody Response to the BNT162b2 mRNA Vaccine in Persons with Past Natural Infection

Authors: Yu Min Kang, Kang-Won Choe, Ki-Deok Lee, Kwang Nam Kim, Moon Jung Kim, Jaegyun Lim

Journal: J Korean Med Sci

PubMed ID: 34490757

Doi: 10.3346/jkms.2021.36.e250

Angiogenesis and nerve regeneration induced by local administration of plasmid into the intact rat sciatic nerve

Authors: Ruslan Masgutov, Alina Zeinalova, Alexey Bogov, Galina Masgutova, Ilnur Salafutdinov, Ekaterina Garanina, Valeriia Syromiatnikova, Kamilla Idrisova, Adelya Mullakhmetova, Dina Andreeva, Liliya Mukhametova, Adilet Kadyrov, Igor Pankov, Albert Rizvanov

Journal: Neural Regen Res

PubMed ID: 33510097

Doi: 10.4103/1673-5374.306090

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Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

Authors: Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara

Journal: Immunity

PubMed ID: 34525338

Doi: 10.1016/j.immuni.2021.08.022

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