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页码: 198/1047 每页显示数量

Physiologically Relevant Free Ca Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6

Authors: Brianna D Young, Kristen M Varney, Paul T Wilder, Brianna K Costabile, Edwin Pozharski, Mary E Cook, Raquel Godoy-Ruiz, Oliver B Clarke, Filippo Mancia, David J Weber

Journal: J Mol Biol

PubMed ID: 34592217

Doi: 10.1016/j.jmb.2021.167272

Products & Services: Protein and Antibody Isolation

Neutralizing Antibodies against SARS-CoV-2, Anti-Ad5 Antibodies, and Reactogenicity in Response to Ad5-nCoV (CanSino Biologics) Vaccine in Individuals with and without Prior SARS-CoV-2

Authors: Jorge Hernández-Bello, José Javier Morales-Núñez, Andrea Carolina Machado-Sulbarán, Saúl Alberto Díaz-Pérez, Paola Carolina Torres-Hernández, Paulina Balcázar-Félix, Jesús Alberto Gutiérrez-Brito, José Alvaro Lomelí-Nieto, José Francisco Muñoz-Valle

Journal: Vaccines (Basel)

PubMed ID: 34579284

Doi: 10.3390/vaccines9091047

A human antibody against human endothelin receptor type A that exhibits antitumor potency

Authors: Man-Seok Ju, Hye-Mi Ahn, Seong-Gu Han, Sanghwan Ko, Jung-Hyun Na, Migyeong Jo, Chung Su Lim, Byoung Joon Ko, Yeon Gyu Yu, Won-Kyu Lee, Youn-Jae Kim, Sang Taek Jung

Journal: Exp Mol Med

PubMed ID: 34588605

Doi: 10.1038/s12276-021-00678-9

Products & Services: Protein and Antibody Isolation

Long noncoding RNA LAMTOR5-AS1 interference affects microRNA-506-3p/E2F6-mediated behavior of non-small cell lung cancer cells

Authors: Guojie Chen, Kai Wang, Guoshu Li, Leidong Wang, Yangyang Xiao, Bo Chen

Journal: Oncol Res

PubMed ID: 34588094

Doi: 10.3727/096504021X16328213967104

Products & Services: Gene Synthesis

Modulation of heterologous protein secretion in the thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC 656 by CRISPR-Cas9 system

Authors: Worarat Kruasuwan, Aekkachai Puseenam, Chitwadee Phithakrotchanakoon, Sutipa Tanapongpipat, Niran Roongsawang

Journal: PLoS ONE

PubMed ID: 34582499

Doi: 10.1371/journal.pone.0258005

Products & Services: Gene Synthesis

Genome editing with type II-C CRISPR-Cas9 systems from Neisseria meningitidis in rice

Authors: Rongfang Xu, Ruiying Qin, Hongjun Xie, Juan Li, Xiaoshuang Liu, Mingdong Zhu, Yang Sun, Yinghong Yu, Pingli Lu, Pengcheng Wei

Journal: Plant Biotechnol J

PubMed ID: 34582079

Doi: 10.1111/pbi.13716

Products & Services: Synthetic Guide RNA

An analysis of antibody responses and clinical sequalae of the Sinopharm HB02 COVID19 vaccine in dialysis patients in the United Arab Emirates

Authors: Stephen Geoffrey Holt, Sally Mahmoud, Wasim Ahmed, Juan Manuel Acuna, Ayman Kamal Al Madani, Islam Eltantawy, Walid Abbas Zaher, Gareth John Goodier, Nawal Ahmed Al Kaabi, Ali Abdulkareem Al Obaidli

Journal: Nephrology (Carlton)

PubMed ID: 34569677

Doi: 10.1111/nep.13980

Myeloma patients with COVID-19 have superior antibody responses compared to patients fully vaccinated with the BNT162b2 vaccine

Authors: Maria Gavriatopoulou, Evangelos Terpos, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Despina Fotiou, Eleni-Dimitra Papanagnou, Magdalini Migkou, Foteini Theodorakakou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Ioannis P Trougakos, Efstathios Kastritis, Meletios-Athanasios Dimopoulos

Journal: Br J Haematol

PubMed ID: 34528249

Doi: 10.1111/bjh.17841

Products & Services: Molecular Biology Reagents

miR‑32‑5p suppresses the proliferation and migration of pancreatic adenocarcinoma cells by targeting TLDC1

Authors: Peng Yuan, Chaofeng Tang, Bendong Chen, Peng Lei, Jianjun Song, Guojun Xin, Zuozheng Wang, Yongfeng Hui, Weijie Yao, Genwang Wang, Guozhong Zhao

Journal: Mol Med Rep

PubMed ID: 34468015

Doi: 10.3892/mmr.2021.12392

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Design and Selection of Engineered Lytic Proteins With Decolonizing Activity

Authors: Diana Gutiérrez, Lorena Rodríguez-Rubio, Patricia Ruas-Madiedo, Lucía Fernández, Ana Belén Campelo, Yves Briers, Martin Weiss Nielsen, Karl Pedersen, Rob Lavigne, Pilar García, Ana Rodríguez

Journal: Front Microbiol

PubMed ID: 34594314

Doi: 10.3389/fmicb.2021.723834

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A phage-encoded nucleoid associated protein compacts both host and phage DNA and derepresses H-NS silencing

Authors: Bokyung Son, Jennifer Patterson-West, Melissa Arroyo-Mendoza, Revathy Ramachandran, James R Iben, Jingen Zhu, Venigalla Rao, Emilios K Dimitriadis, Deborah M Hinton

Journal: Nucleic Acids Res

PubMed ID: 34365505

Doi: 10.1093/nar/gkab678

Products & Services: Gene Synthesis

High-Level Expression of Palmitoylated MPP1 Recombinant Protein in Mammalian Cells

Authors: Agnieszka Chytła, Weronika Gajdzik-Nowak, Agnieszka Biernatowska, Aleksander F Sikorski, Aleksander Czogalla

Journal: Membranes (Basel)

PubMed ID: 34564532

Doi: 10.3390/membranes11090715

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A strategy combining 3D-DNA Walker and CRISPR-Cas12a trans-cleavage activity applied to MXene based electrochemiluminescent sensor for SARS-CoV-2 RdRp gene detection

Authors: Kai Zhang, Zhenqiang Fan, Yue Huang, Yuedi Ding, Minhao Xie

Journal: Talanta

PubMed ID: 34635250

Doi: 10.1016/j.talanta.2021.122868

Products & Services: Gene Synthesis

The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms and in a First-In-Human Phase I Clinical Trial

Authors: Hagen Schwenzer, Erica De Zan, Mustafa Elshani, Ruud van Stiphout, Mary Kudsy, Josephine Morris, Valentina Ferrari, In Hwa Um, James Chettle, Farasat Kazmi, Leticia Campo, Alistair Easton, Sebastian Nijman, Michaela Serpi, Stefan Symeonides, Ruth Plummer, David J Harrison, Gareth Bond, Sarah P Blagden

Journal: Clin Cancer Res

PubMed ID: 34497073

Doi: 10.1158/1078-0432.CCR-21-1652

Products & Services: Plasmid DNA Preparation

Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis

Authors: Benjamin H Jenkins, Finlay Maguire, Guy Leonard, Joshua D Eaton, Steven West, Benjamin E Housden, David S Milner, Thomas A Richards

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34521754

Doi: 10.1073/pnas.2108874118

Products & Services: Plasmid DNA Preparation

Cyclical phosphorylation of LRAP35a and CLASP2 by GSK3β and CK1δ regulates EB1-dependent MT dynamics in cell migration

Authors: Shumei Chia, Thomas Leung, Ivan Tan

Journal: Cell Rep

PubMed ID: 34525355

Doi: 10.1016/j.celrep.2021.109687

Products & Services: Protein and Antibody Isolation

PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer

Authors: Xingang Wang, Yan Zheng, Yu Wang

Journal: Clin Exp Med

PubMed ID: 34554318

Doi: 10.1007/s10238-021-00761-5

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Two novel SARS-CoV-2 surrogate virus neutralization assays are suitable for assessing successful immunization with mRNA-1273

Authors: Alexander Krüttgen, Maike Lauen, Hanna Klingel, Matthias Imöhl, Michael Kleines

Journal: J Virol Methods

PubMed ID: 34563583

Doi: 10.1016/j.jviromet.2021.114297

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics

Authors: Yuan Zhou, Li Zhang, You-Hua Xie, Jian Wu

Journal: Lab Invest

PubMed ID: 34497366

Doi: 10.1038/s41374-021-00663-w

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia

Authors: Lina Abou Saleh, Abigail Boyd, Ileana V Aragon, Anna Koloteva, Domenico Spadafora, Wadad Mneimneh, Robert A Barrington, Wito Richter

Journal: FASEB J

PubMed ID: 34383981

Doi: 10.1096/fj.202100495R

Products & Services: Recombinant Antibody Expression

Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

Authors: Samoil Sekulovski, Pascal Devant, Silvia Panizza, Tasos Gogakos, Anda Pitiriciu, Katharina Heitmeier, Ewan Phillip Ramsay, Marie Barth, Carla Schmidt, Thomas Tuschl, Frank Baas, Stefan Weitzer, Javier Martinez, Simon Trowitzsch

Journal: Nat Commun

PubMed ID: 34584079

Doi: 10.1038/s41467-021-25870-3

Products & Services: Recombinant Antibody Expression

Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In Vitro

Authors: Gang Wang, Jun Guan, Guojun Li, Fengtian Wu, Qin Yang, Chunhong Huang, Junwei Shao, Lichen Xu, Zixuan Guo, Qihui Zhou, Haihong Zhu, Zhi Chen

Journal: Dis Markers

PubMed ID: 34603560

Doi: 10.1155/2021/6803510

Products & Services: Protein and Antibody Isolation

Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression

Authors: Sheng Xu, Huanhuan Tan, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Ping Zhao, Qingyou Xia, Feng Wang

Journal: ACS Appl Mater Interfaces

PubMed ID: 34525798

Doi: 10.1021/acsami.1c08409

Products & Services: Protein and Antibody Isolation

Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation

Authors: Lennart Pusch, Regine Brox, Karl Scheuer, Tadahiro Yokosawa, Mingjian Wu, Benjamin Apeleo Zubiri, Erdmann Spiecker, Klaus D Jandt, Dagmar Fischer, Holger Hackstein

Journal: Nanomedicine (Lond)

PubMed ID: 34523349

Doi: 10.2217/nnm-2021-0022

Products & Services: Protein and Antibody Isolation

Discovery of an Heparin-Binding Epidermal Growth Factor Domain Antibody from a Phage Library and Analysis of Its Inhibitory Effects in SKOV3 Cells

Authors: Peng Lü, Songlin Qiu, Ye Pan, Shenyan Shi, Qian Yu, Feng Yu, Lianjun Miao, Huiying Wang, Keping Chen

Journal: Cancer Biother Radiopharm

PubMed ID: 34529926

Doi: 10.1089/cbr.2021.0123

Products & Services: Protein and Antibody Isolation

METTL3-mediated mA RNA methylation promotes the anti-tumour immunity of natural killer cells

Authors: Hao Song, Jiaxi Song, Ming Cheng, Meijuan Zheng, Tian Wang, Sha Tian, Richard A Flavell, Shu Zhu, Hua-Bing Li, Chen Ding, Haiming Wei, Rui Sun, Hui Peng, Zhigang Tian

Journal: Nat Commun

PubMed ID: 34535671

Doi: 10.1038/s41467-021-25803-0

Products & Services: Protein and Antibody Isolation

Large chromosomal segment deletions by CRISPR/LbCpf1-mediated multiplex gene editing in soybean

Authors: Kaixuan Duan, Yuanyuan Cheng, Jing Ji, Chenchen Wang, Yongshu Wei, Yuanchao Wang

Journal: J Integr Plant Biol

PubMed ID: 34331750

Doi: 10.1111/jipb.13158

Products & Services: Plasmid DNA Preparation

Transcription factors Krüppel-like factor 4 and paired box 5 regulate the expression of the Grainyhead-like genes

Authors: Grzegorz Kotarba, Agnieszka Taracha-Wisniewska, Michal Miller, Michal Dabrowski, Tomasz Wilanowski

Journal: PLoS ONE

PubMed ID: 34570823

Doi: 10.1371/journal.pone.0257977

Products & Services: Plasmid DNA Preparation

Expression, biochemical and structural characterization of high-specific-activity β-amylase from Bacillus aryabhattai GEL-09 for application in starch hydrolysis

Authors: Xuguo Duan, Qiuyu Zhu, Xinyi Zhang, Zhenyan Shen, Yue Huang

Journal: Microb Cell Fact

PubMed ID: 34537082

Doi: 10.1186/s12934-021-01649-5

Products & Services: Plasmid DNA Preparation

Tracing Transmission of Sin Nombre Virus and Discovery of Infection in Multiple Rodent Species

Authors: Samuel M Goodfellow, Robert A Nofchissey, Kurt C Schwalm, Joseph A Cook, Jonathan L Dunnum, Yan Guo, Chunyan Ye, Gregory J Mertz, Kartik Chandran, Michelle Harkins, Daryl B Domman, Darrell L Dinwiddie, Steven B Bradfute

Journal: J Virol

PubMed ID: 34549977

Doi: 10.1128/JVI.01534-21

Products & Services: Plasmid DNA Preparation

The BES1/BZR1-family transcription factor MpBES1 regulates cell division and differentiation in Marchantia polymorpha

Authors: Martin A Mecchia, Mariano García-Hourquet, Fidel Lozano-Elena, Ainoa Planas-Riverola, David Blasco-Escamez, Mar Marquès-Bueno, Santiago Mora-García, Ana I Caño-Delgado

Journal: Curr Biol

PubMed ID: 34529936

Doi: 10.1016/j.cub.2021.08.050

Products & Services: Plasmid DNA Preparation

Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors

Authors: Sangmin Lee

Journal: Biomolecules

PubMed ID: 34572577

Doi: 10.3390/biom11091364

Products & Services: Peptide Synthesis

Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations

Authors: Ryuta Baba, Kenji Oki, Celso E Gomez-Sanchez, Yu Otagaki, Kiyotaka Itcho, Kazuhiro Kobuke, Takaya Kodama, Gaku Nagano, Haruya Ohno, Masayasu Yoneda, Noboru Hattori

Journal: Mol Cell Endocrinol

PubMed ID: 34520814

Doi: 10.1016/j.mce.2021.111456

Products & Services: PCR Cloning and Subcloning

Phycobilin heterologous production from the Rhodophyta Porphyridium cruentum

Authors: Erika Juliana Obando Montoya, Sonia Dorion, Lucía Atehortua-Garcés, Jean Rivoal

Journal: J Biotechnol

PubMed ID: 34500003

Doi: 10.1016/j.jbiotec.2021.09.001

Products & Services: PCR Cloning and Subcloning

Genetic Diversity and Population Structure of Affecting Chickpea in Ethiopia

Authors: Gezahegne Getaneh, Tadele Tefera, Fikre Lemessa, Seid Ahmed, Tarekegn Fite, Jandouwe Villinger

Journal: J Fungi (Basel)

PubMed ID: 34682241

Doi: 10.3390/jof7100820

Products & Services: Nucleic Acid Purification

Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies

Authors: Katherine A Inskeep, Yuri A Zarate, Danielle Monteil, Jurgen Spranger, Dan Doherty, Rolf W Stottmann, K Nicole Weaver

Journal: Am J Med Genet A

PubMed ID: 34523780

Doi: 10.1002/ajmg.a.62497

Products & Services: Mutagenesis Services

Development of A Neonatal Mouse Model for Coxsackievirus B1 Antiviral Evaluation

Authors: Zhichao Yin, Yuanyuan Wu, Rui Zhu, Longfa Xu, Yu Lin, Hongwei Yang, Wenkun Fu, Qiongzi Huang, Dongqing Zhang, Jue Wang, Wei Wang, Yingbin Wang, Tong Cheng, Ningshao Xia

Journal: Virol Sin

PubMed ID: 34581960

Doi: 10.1007/s12250-021-00444-1

Products & Services: Monoclonal Antibody Services

Immunological Response Against SARS-COV-2 After BNT162b2 Vaccine Administration Is Impaired in Allogeneic but Not in Autologous Stem Cell Transplant Recipients

Authors: Martina Chiarucci, Sara Paolasini, Alessandro Isidori, Barbara Guiducci, Federica Loscocco, Maria Capalbo, Giuseppe Visani

Journal: Front Oncol

PubMed ID: 34552880

Doi: 10.3389/fonc.2021.737300

Products & Services: Molecular Biology Reagents

Correction to: Quantitative comparison of PD-L1 IHC assays against NIST standard reference material 1934

Authors: Seshi R Sompuram, Emina E Torlakovic, Nils A 't Hart, Kodela Vani, Steven A Bogen

Journal: Mod Pathol

PubMed ID: 34493826

Doi: 10.1038/s41379-021-00898-4

Products & Services: Mammalian Expression

Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine

Authors: Chen Chen, Yoshiaki Yamanaka, Koji Ueda, Peiying Li, Tamami Miyagi, Yuichiro Harada, Sayaka Tezuka, Satoshi Narumi, Masahiro Sugimoto, Masahiko Kuroda, Yuhei Hayamizu, Kohsuke Kanekura

Journal: J Cell Biol

PubMed ID: 34499080

Doi: 10.1083/jcb.202103160

Products & Services: Mammalian Expression

Seroepidemiology of Infection in the General Population of Northern China: The Jidong Community Cohort Study

Authors: Jingwei Shui, Dongjie Xie, Jianhui Zhao, Cailing Ao, Hongqing Lin, Yuanhao Liang, Haiying Wang, Yingchun Dai, Shixing Tang

Journal: Front Microbiol

PubMed ID: 34650533

Doi: 10.3389/fmicb.2021.729016

Products & Services: Mammalian Expression

A bimolecular fluorescence complementation flow cytometry screen for membrane protein interactions

Authors: Florian Schmitz, Jessica Glas, Richard Neutze, Kristina Hedfalk

Journal: Sci Rep

PubMed ID: 34584201

Doi: 10.1038/s41598-021-98810-2

Products & Services: Mammalian Expression

A versatile genetic engineering toolkit for E coli based on CRISPR-prime editing

Authors: Yaojun Tong, Tue S Jørgensen, Christopher M Whitford, Tilmann Weber, Sang Yup Lee

Journal: Nat Commun

PubMed ID: 34471126

Doi: 10.1038/s41467-021-25541-3

Products & Services: Gene Fragments

Valorization of lignin components into gallate by integrated biological hydroxylation, O-demethylation, and aryl side-chain oxidation

Authors: Chenggu Cai, Zhaoxian Xu, Huarong Zhou, Sitong Chen, Mingjie Jin

Journal: Sci Adv

PubMed ID: 34516898

Doi: 10.1126/sciadv.abg4585

Products & Services: Gene Fragments

Oriented in situ immobilization of a functional tyrosinase on microcrystalline cellulose effectively incorporates DOPA residues in bioengineered mussel adhesive protein

Authors: Suhyeok Kim, Gaeun Bae, Mincheol Shin, Eungsu Kang, Tae Yoon Park, Yoo Seong Choi, Hyung Joon Cha

Journal: Biotechnol J

PubMed ID: 34536060

Doi: 10.1002/biot.202100216

Products & Services: DNA Sequencing

Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi

Authors: Leroy Versteeg, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar-Mondragon, Kathryn M Jones, Peter J Hotez, Maria Elena Bottazzi, Edwin Tijhaar, Jeroen Pollet

Journal: PLoS Negl Trop Dis

PubMed ID: 34478444

Doi: 10.1371/journal.pntd.0009689

Products & Services: DNA Sequencing

Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling

Authors: Taylor P Light, Delphine Brun, Pablo Guardado-Calvo, Riccardo Pederzoli, Ahmed Haouz, Frank Neipel, Félix A Rey, Kalina Hristova, Marija Backovic

Journal: PLoS Biol

PubMed ID: 34499637

Doi: 10.1371/journal.pbio.3001392

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A pH-engineering regenerative DNA tetrahedron ECL biosensor for the assay of SARS-CoV-2 RdRp gene based on CRISPR/Cas12a -activity

Authors: Kai Zhang, Zhenqiang Fan, Yuedi Ding, Minhao Xie

Journal: Chem Eng J

PubMed ID: 34539224

Doi: 10.1016/j.cej.2021.132472

Products & Services: Custom DNA/RNA Oligos

Visualized Multigene Editing System for

Authors: Cen Li, Jingwen Zhou, Shengqi Rao, Guocheng Du, Song Liu

Journal: ACS Synth Biol

PubMed ID: 34555894

Doi: 10.1021/acssynbio.1c00231

Diversion of metabolic flux towards 5-deoxy(iso)flavonoid production via enzyme self-assembly in

Authors: Jianhua Li, Fanglin Xu, Dongni Ji, Chenfei Tian, Yuwei Sun, Ishmael Mutanda, Yuhong Ren, Yong Wang

Journal: Metab Eng Commun

PubMed ID: 34631421

Doi: 10.1016/j.mec.2021.e00185

Products & Services: Codon Optimization