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A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid

Authors: Nemekhbayar Baatartsogt, Yuji Kashiwakura, Morisada Hayakawa, Nobuhiko Kamoshita, Takafumi Hiramoto, Hiroaki Mizukami, Tsukasa Ohmori

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34485602

Doi: 10.1016/j.omtm.2021.06.004

Products & Services: DNA Sequencing

Circular RNA TLK1 Promotes Sepsis-Associated Acute Kidney Injury by Regulating Inflammation and Oxidative Stress Through miR-106a-5p/HMGB1 Axis

Authors: Hai-Ping Xu, Xiao-Ying Ma, Chen Yang

Journal: Front Mol Biosci

PubMed ID: 34250012

Doi: 10.3389/fmolb.2021.660269

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High-resolution structure of the vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine for treating acquired TTP

Authors: Hyun Tae Lee, Ui Beom Park, Tae Jun Jeong, Nahyeon Gu, Sang Hyung Lee, Yujin Kim, Yong-Seok Heo

Journal: Biochem Biophys Res Commun

PubMed ID: 34144500

Doi: 10.1016/j.bbrc.2021.06.030

Products & Services: Codon Optimization

Delayed KCNQ1/KCNE1 assembly on the cell surface helps I fulfil its function as a repolarization reserve in the heart

Authors: Zachary T Wilson, Min Jiang, Jing Geng, Sukhleen Kaur, Samuel W Workman, Jon Hao, Tytus Bernas, Gea-Ny Tseng

Journal: J Physiol

PubMed ID: 33963564

Doi: 10.1113/JP281773

Products & Services: Recombinant Proteins

Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLγ11 and DBLδ-1 Predict Reduction in Parasite Density

Authors: Brittany N Araj, Bruce Swihart, Robert Morrison, Patricia Gonzales Hurtado, Andrew Teo, Almahamoudou Mahamar, Oumar Attaher, Bacary S Diarra, Santara Gaoussou, Djibrilla Issiaka, Alassane Dicko, Patrick E Duffy, Michal Fried

Journal: mSystems

PubMed ID: 34128693

Doi: 10.1128/mSystems.00347-21

Products & Services: Peptide Synthesis

Design of a Near Infrared Fluorescent Ureter Imaging Agent for Prevention of Ureter Damage during Abdominal Surgeries

Authors: Sakkarapalayam M Mahalingam, Karson S Putt, Madduri Srinivasarao, Philip S Low

Journal: Molecules

PubMed ID: 34205289

Doi: 10.3390/molecules26123739

Products & Services: Proteins, Expression, Isolation and Analysis

Structure, immunogenicity, and conformation-dependent receptor binding of the post-fusion human metapneumovirus F protein

Authors: Jiachen Huang, Pradeep Chopra, Lin Liu, Tamas Nagy, Jackelyn Murray, Ralph A Tripp, Geert-Jan Boons, Jarrod J Mousa

Journal: J Virol

PubMed ID: 34160259

Doi: 10.1128/JVI.00593-21

Products & Services: Gene Synthesis

SARS-CoV-2-specific CD8 T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph

Authors: Louise C Rowntree, Jan Petersen, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Adam K Wheatley, Stephen J Kent, Jamie Rossjohn, Katherine Kedzierska, Thi Ho Nguyen

Journal: Immunol Cell Biol

PubMed ID: 34086357

Doi: 10.1111/imcb.12482

Products & Services: Gene Synthesis

Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation

Authors: Naira Samarina, George Ssebyatika, Tanvi Tikla, Ja-Yun Waldmann, Bizunesh Abere, Vittoria Nanna, Michelangelo Marasco, Teresa Carlomagno, Thomas Krey, Thomas F Schulz

Journal: PLoS Pathog

PubMed ID: 34143834

Doi: 10.1371/journal.ppat.1009635

Products & Services: Peptide Synthesis

Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system

Authors: Jason Z Zhang, Hsien-Wei Yeh, Alexandra C Walls, Basile I M Wicky, Kaiti Sprouse, Laura A VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N Pham, John C Kraft, Ian C Haydon, Wei Yang, Michelle DeWitt, Cameron Chow, Lauren Carter, Mark H Wener, Lance Stewart, David Veesler, Michael S Diamond, David Baker

Journal: biorxiv

PubMed ID: 34189528

Doi: 10.1101/2021.06.22.449355

Products & Services: Gene Synthesis

Canine Transforming Growth Factor-β Receptor 2-Ig: A Potential Candidate Biologic for Melanoma Treatment That Reverses Transforming Growth Factor-β1 Immunosuppression

Authors: Hiroto Takeuchi, Satoru Konnai, Naoya Maekawa, Satoshi Takagi, Hiroshi Ohta, Noboru Sasaki, Sangho Kim, Tomohiro Okagawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Journal: Front Vet Sci

PubMed ID: 34195245

Doi: 10.3389/fvets.2021.656715

Products & Services: Codon Optimization

The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype

Authors: Yuchen Jing, Bai Gao, Zhiyang Han, Lifang Xia, Shijie Xin

Journal: Mol Cell Endocrinol

PubMed ID: 34126188

Doi: 10.1016/j.mce.2021.111366

Products & Services: Recombinant Proteins

Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Authors: Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He

Journal: Mol Med Rep

PubMed ID: 34165172

Doi: 10.3892/mmr.2021.12231

Products & Services: Recombinant Proteins

Serological survey of antibodies against SARS-CoV-2 in dogs and cats, Thailand

Authors: Kitikhun Udom, Waleemas Jairak, Ekkapat Chamsai, Kamonpan Charoenkul, Supanat Boonyapisitsopa, Napawan Bunpapong, Navapon Techakriengkrai, Alongkorn Amonsin

Journal: Transbound Emerg Dis

PubMed ID: 34180590

Doi: 10.1111/tbed.14208

Products & Services: Protein Reagents and Products

Design and in silico analysis of a whole-cell biosensor able to kill methicillin-resistant Staphylococcus aureus

Authors: Diego Francisco Benítez-Chao, Francisco de Jesús Balderas-Cisneros, Angel León-Buitimea, José Rubén Morones-Ramírez

Journal: Biotechnol Appl Biochem

PubMed ID: 34081352

Doi: 10.1002/bab.2210

Products & Services: Gene Synthesis

Activation of Protein Tyrosine Phosphatase Receptor Type γ Suppresses Mechanisms of Adhesion and Survival in Chronic Lymphocytic Leukemia Cells

Authors: Alessio Montresor, Lara Toffali, Laura Fumagalli, Gabriela Constantin, Antonella Rigo, Isacco Ferrarini, Fabrizio Vinante, Carlo Laudanna

Journal: J Immunol

PubMed ID: 34162728

Doi: 10.4049/jimmunol.2001462

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In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients

Authors: Raquel Rubio-Acero, Noemi Castelletti, Volker Fingerle, Laura Olbrich, Abhishek Bakuli, Roman Wölfel, Philipp Girl, Katharina Müller, Simon Jochum, Matthias Strobl, Michael Hoelscher, Andreas Wieser

Journal: Infect Dis Ther

PubMed ID: 34155471

Doi: 10.1007/s40121-021-00475-x

Products & Services: Protein Reagents and Products

Circular RNA CDR1as Inhibits the Metastasis of Gastric Cancer through Targeting miR-876-5p/GNG7 Axis

Authors: Jiajia Jiang, Rong Li, Junyi Wang, Jie Hou, Hui Qian, Wenrong Xu

Journal: Gastroenterol Res Pract

PubMed ID: 34221006

Doi: 10.1155/2021/5583029

Products & Services: Gene Synthesis

CRKL is a critical target of Hh-GLI2 pathway in lung adenocarcinoma

Authors: Xiaoming Liu, Yan Hu, Bentong Yu, Kai Peng, Xin Gan

Journal: J Cell Mol Med

PubMed ID: 34076957

Doi: 10.1111/jcmm.16592

Products & Services: Catalog Antibody

A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract

Authors: Qing Chen, Maaike de Vries, Kingsley Okechukwu Nwozor, Jacobien A Noordhoek, Corry-Anke Brandsma, H Marike Boezen, Irene H Heijink

Journal: Front Physiol

PubMed ID: 34163376

Doi: 10.3389/fphys.2021.690936

Products & Services: Gene Synthesis

A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis

Authors: Shiqiang Hou, Gengming Niu, Xin Liu, Pierre M Bourbon, Dongmei Zhang, Pengfei Cui, Kevin Zhao, Dezheng Zhao, Huiyan Zeng

Journal: Microvasc Res

PubMed ID: 34146582

Doi: 10.1016/j.mvr.2021.104209

Products & Services: Catalog Antibody

Secondary Structure of the Novel Myosin Binding Domain WYR and Implications within Myosin Structure

Authors: Lynda M Menard, Neil B Wood, Jim O Vigoreaux

Journal: Biology (Basel)

PubMed ID: 34209926

Doi: 10.3390/biology10070603

Products & Services: Peptide Synthesis

Identification of ACE2 modifiers by CRISPR screening

Authors: Emily J Sherman, Carmen Mirabelli, Vi T Tang, Taslima G Khan, Andrew A Kennedy, Sarah E Graham, Cristen J Willer, Andrew W Tai, Jonathan Z Sexton, Christiane E Wobus, Brian T Emmer

Journal: biorxiv

PubMed ID: 34127970

Doi: 10.1101/2021.06.10.447768

Products & Services: Oligo pool

Nucleoprotein (P40) Binding to 5HT2C Receptors (5HT2CR) is the Key Point in the Pathogenesis of BoDV-1-Infected Hosts

Authors: Yuanxin Li, Lixin Wang, Xueni Liu, Ying Huang, Xiaomei Li, Hong He, Xiaoyan Xu, Yujie Guo, Qi Li, Dan Zhu, Xingyu Wang, Haiyang Wang, Wenwen Li, Dan Li, Peng Xie

Journal: Neurochem Res

PubMed ID: 34165668

Doi: 10.1007/s11064-021-03385-z

Products & Services: Catalog Antibody

Large-Scale Oligonucleotide Synthesis for Whole-Genome Synthesis and Data Storage: Challenges and Opportunities

Authors: Li-Fu Song, Zheng-Hua Deng, Zi-Yi Gong, Lu-Lu Li, Bing-Zhi Li

Journal: Front Bioeng Biotechnol

PubMed ID: 34239862

Doi: 10.3389/fbioe.2021.689797

Products & Services: Oligo pool

Programming Cells by Multicopy Chromosomal Integration Using CRISPR-Associated Transposases

Authors: Yiwen Zhang, Jiawei Yang, Siqi Yang, Jieze Zhang, Jun Chen, Rongsheng Tao, Yu Jiang, Junjie Yang, Sheng Yang

Journal: CRISPR J

PubMed ID: 34152213

Doi: 10.1089/crispr.2021.0018

Products & Services: Gene Synthesis

Comparing Results of Five SARS-CoV-2 Antibody Assays Before and After the First Dose of ChAdOx1 nCoV-19 Vaccine among Health Care Workers

Authors: Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun Ju Jung, Heungjeong Woo, Yu Bin Seo, Jin Ju Park, Hyun Soo Kim

Journal: J Clin Microbiol

PubMed ID: 34191577

Doi: 10.1128/JCM.01105-21

Products & Services: Protein Reagents and Products

Absence of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in stray cats

Authors: Angelica Stranieri, Stefania Lauzi, Alessia Giordano, Luigi Galimberti, Gabriele Ratti, Nicola Decaro, Federica Brioschi, Davide Lelli, Silvia Gabba, Ndiana Linda Amarachi, Eleonora Lorusso, Ana Moreno, Tiziana Trogu, Saverio Paltrinieri

Journal: Transbound Emerg Dis

PubMed ID: 34170624

Doi: 10.1111/tbed.14200

Products & Services: Gene Synthesis

Model infant biscuits release the opioid-acting peptides milk β-casomorphins and gluten exorphins after in vitro gastrointestinal digestion

Authors: Valentina Pica, Milda Stuknytė, Fabio Masotti, Ivano De Noni, Stefano Cattaneo

Journal: Food Chem

PubMed ID: 34118509

Doi: 10.1016/j.foodchem.2021.130262

Products & Services: Peptide Synthesis

De novo biosynthesis of -arabinosylated flavones by utilization of rice -glycosyltransferases

Authors: Zhuo Chen, Yuwei Sun, Guangyi Wang, Ying Zhang, Qian Zhang, Yulian Zhang, Jianhua Li, Yong Wang

Journal: Bioresour Bioprocess

PubMed ID: 34150466

Doi: 10.1186/s40643-021-00404-3

Products & Services: Gene Synthesis

ptFVa ( Venom-Derived Factor Va) Retains Structural Integrity Following Proteolysis by Activated Protein C

Authors: Mark Schreuder, Xiaosong Liu, Ka Lei Cheung, Pieter H Reitsma, Gerry A F Nicolaes, Mettine H A Bos

Journal: Arterioscler Thromb Vasc Biol

PubMed ID: 34162230

Doi: 10.1161/ATVBAHA.121.316038

Products & Services: Gene Synthesis

Evaluation of a Surrogate ELISA- Based Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) cPass Neutralization Antibody Detection Assay and Correlation with IgG Commercial Serology Assays

Authors: Vijayalakshmi Nandakumar, Tracie Profaizer, Bucky K Lozier, Marc G Elgort, Erin T Larragoite, Elizabeth S C P Williams, Antonio Solis-Leal, J Brandon Lopez, Bradford K Berges, Vicente Planelles, Jenna Rychert, Patricia R Slev, Julio C Delgado

Journal: Arch Pathol Lab Med

PubMed ID: 34181714

Doi: 10.5858/arpa.2021-0213-SA

Products & Services: Protein Reagents and Products

Evaluating a new mixed-mode resin Diamond MMC Mustang using Capto MMC ImpRes as a benchmark

Authors: Shengwei Zhang, Yan Wan, Jiwei Duan, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 34147604

Doi: 10.1016/j.pep.2021.105930

Products & Services: Nucleic Acid Purification & Analysis

Focused peptide library screening as a route to a superior affinity ligand for antibody purification

Authors: Krištof Bozovičar, Barbara Jenko Bizjan, Anže Meden, Jernej Kovač, Tomaž Bratkovič

Journal: Sci Rep

PubMed ID: 34079028

Doi: 10.1038/s41598-021-91208-0

Products & Services: Codon Optimization

Metaproteomic Discovery and Characterization of a Novel Lipolytic Enzyme From an Indian Hot Spring

Authors: Dennis Sander, Yanfei Yu, Premankur Sukul, Sina Schäkermann, Julia E Bandow, Trinetra Mukherjee, Subhra Kanti Mukhopadhyay, Lars I Leichert

Journal: Front Microbiol

PubMed ID: 34149658

Doi: 10.3389/fmicb.2021.672727

Products & Services: Gene Synthesis

Immunogenic potential of DNA vaccine candidate, ZyCoV-D against SARS-CoV-2 in animal models

Authors: Ayan Dey, T M Chozhavel Rajanathan, Harish Chandra, Hari P R Pericherla, Sanjeev Kumar, Huzaifa S Choonia, Mayank Bajpai, Arun K Singh, Anuradha Sinha, Gurwinder Saini, Parth Dalal, Sarosh Vandriwala, Mohammed A Raheem, Rupesh D Divate, Neelam L Navlani, Vibhuti Sharma, Aashini Parikh, Siva Prasath, M Sankar Rao, Kapil Maithal

Journal: Vaccine

PubMed ID: 34120764

Doi: 10.1016/j.vaccine.2021.05.098

Products & Services: Proteins, Expression, Isolation and Analysis

Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design

Authors: Daniel Ellis, Natalie Brunette, Katharine H D Crawford, Alexandra C Walls, Minh N Pham, Chengbo Chen, Karla-Luise Herpoldt, Brooke Fiala, Michael Murphy, Deleah Pettie, John C Kraft, Keara D Malone, Mary Jane Navarro, Cassandra Ogohara, Elizabeth Kepl, Rashmi Ravichandran, Claire Sydeman, Maggie Ahlrichs, Max Johnson, Alyssa Blackstone, Lauren Carter, Tyler N Starr, Allison J Greaney, Kelly K Lee, David Veesler, Jesse D Bloom, Neil P King

Journal: Front Immunol

PubMed ID: 34267764

Doi: 10.3389/fimmu.2021.710263

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Temporal induction of Lhx8 by optogenetic control system for efficient bone regeneration

Authors: Delan Huang, Runze Li, Jianhan Ren, Haotian Luo, Weicai Wang, Chen Zhou

Journal: Stem Cell Res Ther

PubMed ID: 34112263

Doi: 10.1186/s13287-021-02412-8

Products & Services: Plasmid DNA Preparation

Tanshinones induce tumor cell apoptosis via directly targeting FHIT

Authors: Xianglian Zhou, Yuting Pan, Yue Wang, Bojun Wang, Yu Yan, Yi Qu, Xisong Ke

Journal: Sci Rep

PubMed ID: 34108553

Doi: 10.1038/s41598-021-91708-z

Products & Services: Mammalian Expression

The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ

Authors: Denis A Kiktev, Margaret Dominska, Tony Zhang, Joseph Dahl, Elena I Stepchenkova, Piotr Mieczkowski, Peter M Burgers, Scott Lujan, Adam Burkholder, Thomas A Kunkel, Thomas D Petes

Journal: Nucleic Acids Res

PubMed ID: 34019669

Doi: 10.1093/nar/gkab371

Products & Services: Gene Synthesis

Impact of CRISPR-Cas9-Based Genome Engineering in Farm Animals

Authors: Parul Singh, Syed Azmal Ali

Journal: Vet Sci

PubMed ID: 34209174

Doi: 10.3390/vetsci8070122

Synchrotron Radiation-Fourier Transformed Infrared microspectroscopy (μSR-FTIR) reveals multiple metabolism alterations in microalgae induced by cadmium and mercury

Authors: Ángel Barón-Sola, Margarita Toledo-Basantes, María Arana-Gandía, Flor Martínez, Cristina Ortega-Villasante, Tanja Dučić, Ibraheem Yousef, Luis E Hernández

Journal: J Hazard Mater

PubMed ID: 34214848

Doi: 10.1016/j.jhazmat.2021.126502

Products & Services: Proteins, Expression, Isolation and Analysis

LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage

Authors: Vinod Tiwari, Tomasz Kulikowicz, David M Wilson, Vilhelm A Bohr

Journal: Nucleic Acids Res

PubMed ID: 34096589

Doi: 10.1093/nar/gkab458

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted Radionuclide Therapy Using Auger Electron Emitters: The Quest for the Right Vector and the Right Radionuclide

Authors: Malick Bio Idrissou, Alexandre Pichard, Bryan Tee, Tibor Kibedi, Sophie Poty, Jean-Pierre Pouget

Journal: Pharmaceutics

PubMed ID: 34209637

Doi: 10.3390/pharmaceutics13070980

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A Novel Plasmid DNA-Based Foot and Mouth Disease Virus Minigenome for Intracytoplasmic mRNA Production

Authors: Ploypailin Semkum, Challika Kaewborisuth, Nattarat Thangthamniyom, Sirin Theerawatanasirikul, Chalermpol Lekcharoensuk, Payuda Hansoongnern, Pongrama Ramasoota, Porntippa Lekcharoensuk

Journal: Viruses

PubMed ID: 34205958

Doi: 10.3390/v13061047

Products & Services: Recombinant Proteins

Proteoform Differentiation using Tandem Trapped Ion Mobility, Electron Capture Dissociation, and ToF Mass Spectrometry

Authors: Kevin Jeanne Dit Fouque, Desmond Kaplan, Valery G Voinov, Frederik H V Holck, Ole N Jensen, Francisco Fernandez-Lima

Journal: Anal Chem

PubMed ID: 34170114

Doi: 10.1021/acs.analchem.1c01735

Products & Services: Recombinant Proteins

Function is more reliable than quantity to follow up the humoral response to the Receptor Binding Domain of SARS- CoV-2 Spike protein after natural infection or COVID-19 vaccination

Authors: Carlos A Sariol, Petraleigh Pantoja, Crisanta Serrano-Collazo, Tiffany Rosa-Arocho, Albersy Armina, Lorna Cruz, E Taylor Stone, Teresa Arana, Consuelo Climent, Gerardo Latoni, Dianne Atehortua, Christina Pabon-Carrero, Amelia K Pinto, James D Brien, Ana M Espino

Journal: medrxiv

PubMed ID: 34100029

Doi: 10.1101/2021.06.02.21257975

Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans

Authors: Shai Abehsera, Shmuel Bentov, Xuguang Li, Simy Weil, Rivka Manor, Shahar Sagi, Shihao Li, Fuhua Li, Isam Khalaila, Eliahu D Aflalo, Amir Sagi

Journal: Sci Rep

PubMed ID: 34083647

Doi: 10.1038/s41598-021-91155-w

Products & Services: Proteins, Expression, Isolation and Analysis

"Resurrected" human-source urate oxidase with high uricolytic activity and stability

Authors: Nan Jiang, Chunqin Xu, Linhan Zhang, Jianhua Chen

Journal: Enzyme Microb Technol

PubMed ID: 34311889

Doi: 10.1016/j.enzmictec.2021.109852

Products & Services: GenParts™ DNA Fragments

"Resurrected" human-source urate oxidase with high uricolytic activity and stability

Authors: Nan Jiang, Chunqin Xu, Linhan Zhang, Jianhua Chen

Journal: Enzyme Microb Technol

PubMed ID: 34311889

Doi: 10.1016/j.enzmictec.2021.109852

Products & Services: GenParts™ DNA Fragments

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