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Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

Authors: Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara

Journal: Immunity

PubMed ID: 34525338

Doi: 10.1016/j.immuni.2021.08.022

Products & Services: Stable Cell Lines

Development of a Recombinant RBD Subunit Vaccine for SARS-CoV-2

Authors: Yi-Sheng Sun, Jing-Jing Zhou, Han-Ping Zhu, Fang Xu, Wen-Bin Zhao, Hang-Jing Lu, Zhen Wang, Shu-Qing Chen, Ping-Ping Yao, Jian-Min Jiang, Zhan Zhou

Journal: Viruses

PubMed ID: 34696367

Doi: 10.3390/v13101936

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice

Authors: Donghui Zhang, Hong Zhu, Enbo Zhan, Fan Wang, Yue Liu, Wei Xu, Xian Liu, Jingjin Liu, Shufeng Li, Yong Pan, Yongshun Wang, Wei Cao

Journal: Front Cell Dev Biol

PubMed ID: 34631690

Doi: 10.3389/fcell.2021.647131

Products & Services: Recombinant Antibody Expression

Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain

Authors: Stefano Suzzi, Reiner Ahrendt, Stefan Hans, Svetlana A Semenova, Avinash Chekuru, Paul Wirsching, Volker Kroehne, Saygın Bilican, Shady Sayed, Sylke Winkler, Sandra Spieß, Anja Machate, Jan Kaslin, Pertti Panula, Michael Brand

Journal: PLoS Genet

PubMed ID: 34516550

Doi: 10.1371/journal.pgen.1009794

Products & Services: Protein Electrophoresis and Western

The evidence for and consequences of metabotropic glutamate receptor heterodimerization

Authors: Tyler W McCullock, Paul J Kammermeier

Journal: Neuropharmacology

PubMed ID: 34547332

Doi: 10.1016/j.neuropharm.2021.108801

Products & Services: Protein and Antibody Isolation

Tagging and Capturing of Lentiviral Vectors Using Short RNAs

Authors: Martin Panigaj, Michael P Marino, Jakob Reiser

Journal: Int J Mol Sci

PubMed ID: 34638603

Doi: 10.3390/ijms221910263

Products & Services: Plasmid DNA Preparation

RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates

Authors: Xiaoyan Pan, Jian Shi, Xue Hu, Yan Wu, Liang Zeng, Yanfeng Yao, Weijuan Shang, Kunpeng Liu, Ge Gao, Weiwei Guo, Yun Peng, Shaohong Chen, Xiaoxiao Gao, Cheng Peng, Juhong Rao, Jiaxuan Zhao, Cheng Gong, Hui Zhou, Yudong Lu, Zili Wang, Xiliang Hu, WenJuan Cong, Lijuan Fang, Yongxiang Yan, Jing Zhang, Hui Xiong, Jizu Yi, Zhiming Yuan, Pengfei Zhou, Chao Shan, Gengfu Xiao

Journal: Cell Discov

PubMed ID: 34493710

Doi: 10.1038/s41421-021-00320-y

Products & Services: Plasmid DNA Preparation

Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

Authors: Debashis Dutta, Malabendu Jana, Moumita Majumder, Susanta Mondal, Avik Roy, Kalipada Pahan

Journal: Nat Commun

PubMed ID: 34508096

Doi: 10.1038/s41467-021-25767-1

Products & Services: Peptide Synthesis

Mass balance method for SI-traceable purity assignment of synthetic oxytocin

Authors: Sheng Wang, Peize Wu, Ming Li, Ting Huang, Naijie Shi, Liuxing Feng, Hongmei Li

Journal: J Pharm Biomed Anal

PubMed ID: 34656934

Doi: 10.1016/j.jpba.2021.114401

Products & Services: Peptide Synthesis

Surface-enhanced Raman scattering-based detection of plasmin activity by specific peptide substrate

Authors: Nazife Nur Yazgan, Tugba Bulat, Ali Topcu, Fahriye Ceyda Dudak, Ismail Hakki Boyaci, Uğur Tamer

Journal: Food Chem

PubMed ID: 34624781

Doi: 10.1016/j.foodchem.2021.131235

Products & Services: Peptide Synthesis

Identification and Characterization of Rift Valley Fever Virus-Specific T Cells Reveals a Dependence on CD40/CD40L Interactions for Prevention of Encephalitis

Authors: Dominique J Barbeau, Haley N Cartwright, Jessica R Harmon, Jessica R Spengler, Christina F Spiropoulou, John Sidney, Alessandro Sette, Anita K McElroy

Journal: J Virol

PubMed ID: 34495703

Doi: 10.1128/JVI.01506-21

Products & Services: Peptide Synthesis

Optimised Heterologous Expression and Functional Analysis of the F1-Capsular Antigen Regulator Caf1R

Authors: Dharmender K Gahlot, Gyles Ifill, Sheila MacIntyre

Journal: Int J Mol Sci

PubMed ID: 34575967

Doi: 10.3390/ijms22189805

Products & Services: ORF cDNA Clones/MolecularCloud

Glucagon-Like Peptide-2 Modulates Enteric Paneth Cells Immune Response and Alleviates Gut Inflammation During Intravenous Fluid Infusion in Mice With a Central Catheter

Authors: Guifang Deng, Qiucheng Lei, Xuejin Gao, Yupeng Zhang, Huazhen Zheng, Jingcheng Bi, Xinying Wang

Journal: Front Nutr

PubMed ID: 34540875

Doi: 10.3389/fnut.2021.688715

Products & Services: Nucleic Acid Purification

Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity

Authors: Ashley C Dougherty, Mariam G Hawaz, Kristine G Hoang, Judy Trac, Jacob M Keck, Carmen Ayes, Joseph E Deweese

Journal: ACS Omega

PubMed ID: 34660952

Doi: 10.1021/acsomega.1c02083

Products & Services: Mutagenesis Services

The DNA Recognition Motif of GapR Has an Intrinsic DNA Binding Preference towards AT-rich DNA

Authors: Qian Huang, Bo Duan, Zhi Qu, Shilong Fan, Bin Xia

Journal: Molecules

PubMed ID: 34641320

Doi: 10.3390/molecules26195776

Products & Services: Mutagenesis Services

Author Correction: Enhanced genome editing efficiency of CRISPR PLUS: Cas9 chimeric fusion proteins

Authors: Jongjin Park, Jiyoung Yoon, Daekee Kwon, Mi-Jung Han, Sunmee Choi, Slki Park, Junghyuk Lee, Kiwook Lee, Jaehwan Lee, Seunghee Lee, Kyung-Sun Kang, Sunghwa Choe

Journal: Sci Rep

PubMed ID: 34508163

Doi: 10.1038/s41598-021-98186-3

Products & Services: Mammalian Expression

Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools

Authors: Viktor Mojr, Mohammad Roghanian, Hedvig Tamman, Duy Dinh Do Pham, Magdalena Petrová, Radek Pohl, Hiraku Takada, Katleen Van Nerom, Hanna Ainelo, Julien Caballero-Montes, Steffi Jimmy, Abel Garcia-Pino, Vasili Hauryliuk, Dominik Rejman

Journal: ACS Chem Biol

PubMed ID: 34477366

Doi: 10.1021/acschembio.1c00398

Products & Services: Mammalian Expression

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

Authors: Eleonora Turco, Adriana Savova, Flora Gere, Luca Ferrari, Julia Romanov, Martina Schuschnig, Sascha Martens

Journal: Nat Commun

PubMed ID: 34471133

Doi: 10.1038/s41467-021-25572-w

Products & Services: Insect Expression

Multiple strategies for metabolic engineering of Escherichia coli for efficient production of glycolate

Authors: Tong Zhu, Die Yao, Di Li, Hongtao Xu, Shiru Jia, Changhao Bi, Jun Cai, Xinna Zhu, Xueli Zhang

Journal: Biotechnol Bioeng

PubMed ID: 34491579

Doi: 10.1002/bit.27934

Products & Services: Gene Fragments

Spectroscopic and functional characterization of the [2Fe-2S] scaffold protein Nfu from Synechocystis PCC6803

Authors: Zechariah Thompson, Insiya Fidai, Christine Wachnowsky, Amber L Hendricks, J A Cowan

Journal: Biochimie

PubMed ID: 34582998

Doi: 10.1016/j.biochi.2021.09.013

Products & Services: Gene Synthesis

Application of the amplification-free SERS-based CRISPR/Cas12a platform in the identification of SARS-CoV-2 from clinical samples

Authors: Jiajie Liang, Peijun Teng, Wei Xiao, Guanbo He, Qifang Song, Ying Zhang, Bin Peng, Gan Li, Liangshan Hu, Donglin Cao, Yong Tang

Journal: J Nanobiotechnology

PubMed ID: 34496881

Doi: 10.1186/s12951-021-01021-0

Products & Services: DNA Sequencing

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Authors: Stephanie Patchett, Zongyang Lv, Wioletta Rut, Miklos Békés, Marcin Drag, Shaun K Olsen, Tony T Huang

Journal: Cell Rep

PubMed ID: 34547223

Doi: 10.1016/j.celrep.2021.109754

Products & Services: DNA Sequencing

Fusion of cellobiose phosphorylase and potato alpha-glucan phosphorylase facilitates substrate channeling for enzymatic conversion of cellobiose to starch

Authors: Xinyu Liu, Huawei Hou, Yapeng Li, Sen Yang, Hui Lin, Hongge Chen

Journal: Prep Biochem Biotechnol

PubMed ID: 34550864

Doi: 10.1080/10826068.2021.1977949

Products & Services: DNA Sequencing

Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae

Authors: Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P Shanbhag, Sreenath Rajagopal, Teby Thomas, Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta, Satoshi Murakami

Journal: Nat Commun

PubMed ID: 34518546

Doi: 10.1038/s41467-021-25679-0

Products & Services: DNA Sequencing

Association of a GATA Binding Protein 4 Polymorphism with the Risk of Hypospadias in the Chinese Children

Authors: Jiawei Chen, Xinhai Cui, Aiwu Li, Guowei Li, Fengyin Sun

Journal: Urol Int

PubMed ID: 34569527

Doi: 10.1159/000518644

Products & Services: Custom Vector Construction

NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain

Authors: Bing Wang, Dmitri Svetlov, Irina Artsimovitch

Journal: Nucleic Acids Res

PubMed ID: 34352100

Doi: 10.1093/nar/gkab677

Products & Services: Custom Vector Construction

A genome-wide screen reveals the involvement of enterobactin-mediated iron acquisition in Escherichia coli survival during copper stress

Authors: Kaitlin Casanova-Hampton, Alexis Carey, Sarah Kassam, Alyssa Garner, George L Donati, Shankar Thangamani, Sargurunathan Subashchandrabose

Journal: Metallomics

PubMed ID: 34415046

Doi: 10.1093/mtomcs/mfab052

Products & Services: Custom Vector Construction

De novo design of tyrosine and serine kinase-driven protein switches

Authors: Nicholas B Woodall, Zara Weinberg, Jesslyn Park, Florian Busch, Richard S Johnson, Mikayla J Feldbauer, Michael Murphy, Maggie Ahlrichs, Issa Yousif, Michael J MacCoss, Vicki H Wysocki, Hana El-Samad, David Baker

Journal: Nat Struct Mol Biol

PubMed ID: 34518698

Doi: 10.1038/s41594-021-00649-8

Products & Services: Custom Vector Construction

The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity

Authors: Konrad J Mostert, Nandini Sharma, Marianne van der Zwaag, Roxine Staats, Lizbé Koekemoer, Ruchi Anand, Ody C M Sibon, Erick Strauss

Journal: ACS Chem Biol

PubMed ID: 34582681

Doi: 10.1021/acschembio.1c00535

Products & Services: Custom Vector Construction

Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker

Authors: Liya Wang, Hanan Sharif, Sara Saellström, Henrik Rönnberg, Staffan Eriksson

Journal: BMC Vet Res

PubMed ID: 34579716

Doi: 10.1186/s12917-021-03030-5

Products & Services: Custom Vector Construction

Molecular basis of human ATM kinase inhibition

Authors: K Stakyte, M Rotheneder, K Lammens, J D Bartho, U Grädler, T Fuchß, U Pehl, A Alt, E van de Logt, K P Hopfner

Journal: Nat Struct Mol Biol

PubMed ID: 34556870

Doi: 10.1038/s41594-021-00654-x

Products & Services: Custom Vector Construction

Zinc-finger protein MdBBX7/MdCOL9, a target of MdMIEL1 E3 ligase, confers drought tolerance in apple

Authors: Pengxiang Chen, Fang Zhi, Xuewei Li, Wenyun Shen, Mingjia Yan, Jieqiang He, Chana Bao, Tianle Fan, Shuangxi Zhou, Fengwang Ma, Qingmei Guan

Journal: Plant Physiol

PubMed ID: 34618120

Doi: 10.1093/plphys/kiab420

Products & Services: Custom RNAi Services

Spectroscopic evidence of tetanus toxin translocation domain bilayer-induced refolding and insertion

Authors: Pierce T O'Neil, Victor Vasquez-Montes, Liskin Swint-Kruse, Michael R Baldwin, Alexey S Ladokhin

Journal: Biophys J

PubMed ID: 34555358

Doi: 10.1016/j.bpj.2021.09.030

Products & Services: Codon Optimization

Spike protein of SARS-CoV-2 activates macrophages and contributes to induction of acute lung inflammation in male mice

Authors: Xiaoling Cao, Yan Tian, Vi Nguyen, Yuping Zhang, Chao Gao, Rong Yin, Wayne Carver, Daping Fan, Helmut Albrecht, Taixing Cui, Wenbin Tan

Journal: FASEB J

PubMed ID: 34365657

Doi: 10.1096/fj.202002742RR

Products & Services: Codon Optimization

Biomimetic and mechanically supportive 3D printed scaffolds for cartilage and osteochondral tissue engineering using photopolymers and digital light processing

Authors: Sarah A Schoonraad, Kristine M Fischenich, Kevin N Eckstein, Victor Crespo-Cuevas, Lea M Savard, Archish Muralidharan, Andrew A Tomaschke, Asais Camila Uzcategui, Mark A Randolph, Robert R McLeod, Virginia L Ferguson, Stephanie J Bryant

Journal: Biofabrication

PubMed ID: 34479218

Doi: 10.1088/1758-5090/ac23ab

Products & Services: Catalog Peptides

Serological Assays for Assessing Postvaccination SARS-CoV-2 Antibody Response

Authors: Sally A Mahmoud, Subhashini Ganesan, Shivaraj Naik, Safaa Bissar, Isra Al Zamel, K N Warren, Walid A Zaher, Gulfaraz Khan

Journal: Microbiol Spectr

PubMed ID: 34585943

Doi: 10.1128/Spectrum.00733-21

Products & Services: Serology SARS-Cov-2 detection kits

Isotype-Specific Fc Effector Functions Enhance Antibody-Mediated Rift Valley Fever Virus Protection

Authors: Haley N Cartwright, Dominique J Barbeau, Anita K McElroy

Journal: mSphere

PubMed ID: 34494884

Doi: 10.1128/mSphere.00556-21

Products & Services: Catalog Antibodies

Lysine Residues in the MK-Rich Region Are Not Required for Binding of the PbsP Protein From Group B Streptococci to Plasminogen

Authors: Francesco Coppolino, Letizia Romeo, Giampiero Pietrocola, Germana Lentini, Giuseppe Valerio De Gaetano, Giuseppe Teti, Roberta Galbo, Concetta Beninati

Journal: Front Cell Infect Microbiol

PubMed ID: 34568085

Doi: 10.3389/fcimb.2021.679792

Products & Services: Peptide Synthesis

Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs

Authors: Lifeng Fu, Shuai Shao, Yong Feng, Fei Ye, Xue Sun, Qingling Wang, Feng Yu, Qisheng Wang, Baoying Huang, Peihua Niu, Xuebing Li, Catherine C L Wong, Jianxun Qi, Wenjie Tan, George Fu Gao

Journal: MBio

PubMed ID: 34579576

Doi: 10.1128/mBio.02220-21

Products & Services: Peptide Synthesis

Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation

Authors: Hongyi Zhou, Huabo Su, Weiqin Chen

Journal: Int J Mol Sci

PubMed ID: 34502418

Doi: 10.3390/ijms22179509

Products & Services: CRISPR Plasmids

A Cross-Reactive Monoclonal Antibody Against Neuraminidases of Both H9N2 and H3N2 Influenza Viruses Shows Protection in Mice Challenging Models

Authors: Fei Wang, Zhimin Wan, Jinsen Wu, Yajuan Wang, Hui Fu, Hongxia Shao, Kun Qian, Wei Gao, Jianqiang, Aijian Qin

Journal: Frontiers in Microbiology

Doi: 10.3389/fmicb.2021.730449

Products & Services: Gene Synthesis

Angiogenesis and nerve regeneration induced by local administration of plasmid into the intact rat sciatic nerve

Authors: Ruslan Masgutov, Alina Zeinalova, Alexey Bogov, Galina Masgutova, Ilnur Salafutdinov, Ekaterina Garanina, Valeriia Syromiatnikova, Kamilla Idrisova, Adelya Mullakhmetova, Dina Andreeva, Liliya Mukhametova, Adilet Kadyrov, Igor Pankov, Albert Rizvanov

Journal: Neural Regen Res

PubMed ID: 33510097

Doi: 10.4103/1673-5374.306090

Products & Services: Gene Synthesis

ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier

Authors: Xihua Yue , Yi Qian , Lianhui Zhu , Bopil Gim, Mengjing Bao , Jie Jia , Shuaiyang Jing , Yijing Wang , Chuanting Tan , Francesca Bottanelli , Pascal Ziltener , Sunkyu Choi , Piliang Hao , Intaek Lee

Journal: BMC Biol

PubMed ID: 34493279

Doi: 10.1186/s12915-021-01137-7

Products & Services: Protein and Antibody Isolation

Insertion of prpoD_rpoS fragment enhances expression of recombinant protein by dps auto-inducible promoter in Escherichia coli

Authors: Dina Mulyanti, Sundani Nurono Soewandhi, Catur Riani

Journal: Mol Biol Rep

PubMed ID: 34342815

Doi: 10.1007/s11033-021-06562-z

Products & Services: Plasmid DNA Preparation

Structural elements determining the transglycosylating activity of glycoside hydrolase family 57 glycogen branching enzymes

Authors: Gang Xiang, Hans Leemhuis, Marc Jos Elise Cornelis van der Maarel

Journal: Proteins

PubMed ID: 34346105

Doi: 10.1002/prot.26200

Products & Services: Plasmid DNA Preparation

A Single-Cycle Influenza A Virus-Based SARS-CoV-2 Vaccine Elicits Potent Immune Responses in a Mouse Model

Authors: Surapong Koonpaew, Challika Kaewborisuth, Kanjana Srisutthisamphan, Asawin Wanitchang, Theeradej Thaweerattanasinp, Janya Saenboonrueng, Sukontip Poonsuk, Juggragarn Jengarn, Ratchanont Viriyakitkosol, Jarin Kramyu, Anan Jongkaewwattana

Journal: Vaccines (Basel)

PubMed ID: 34451975

Doi: 10.3390/vaccines9080850

Products & Services: Plasmid DNA Preparation

Tracking the Amide I and αCOO- Terminal ν(C=O) Raman Bands in a Family of l-Glutamic Acid-Containing Peptide Fragments: A Raman and DFT Study

Authors: Ashley E Williams, Nathan I Hammer, Ryan C Fortenberry, Dana N Reinemann

Journal: Molecules

PubMed ID: 34443382

Doi: 10.3390/molecules26164790

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Inhibition of the HIF-1α/BNIP3 pathway has a retinal neuroprotective effect

Authors: Hiromitsu Kunimi, Deokho Lee, Mari Ibuki, Yusaku Katada, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara

Journal: FASEB J

PubMed ID: 34314069

Doi: 10.1096/fj.202100572R

Products & Services: Plasmid DNA Preparation

Adsorption of Recombinant Human β-Defensin 2 and Two Mutants on Mesoporous Silica Nanoparticles and Its Effect against subsp

Authors: Gabriel Marcelino-Pérez, Roberto Ruiz-Medrano, Salvador Gallardo-Hernández, Beatriz Xoconostle-Cázares

Journal: Nanomaterials (Basel)

PubMed ID: 34443974

Doi: 10.3390/nano11082144

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Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection

Authors: Audrey V Parent, Gaetano Faleo, Jessica Chavez, Michael Saxton, David I Berrios, Natanya R Kerper, Qizhi Tang, Matthias Hebrok

Journal: Cell Rep

PubMed ID: 34407395

Doi: 10.1016/j.celrep.2021.109538

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