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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

Authors: Robert L Summers, Charisse Flerida A Pasaje, Joao P Pisco, Josefine Striepen, Madeline R Luth, Krittikorn Kumpornsin, Emma F Carpenter, Justin T Munro, De Lin, Andrew Plater, Avinash S Punekar, Andrew M Shepherd, Sharon M Shepherd, Manu Vanaerschot, James M Murithi, Kelly Rubiano, Aslı Akidil, Sabine Ottilie, Nimisha Mittal, A Hazel Dilmore, Madalyn Won, Rebecca E K Mandt, Kerry McGowen, Edward Owen, Chris Walpole, Manuel Llinás, Marcus C S Lee, Elizabeth A Winzeler, David A Fidock, Ian H Gilbert, Dyann F Wirth, Jacquin C Niles, Beatriz Baragaña, Amanda K Lukens

Journal: Cell Chem Biol

PubMed ID: 34348113

Doi: 10.1016/j.chembiol.2021.07.010

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Disrupts VE-Cadherin Intercellular Junctions and Traverses Endothelial Barriers Using a Cholesterol-Dependent Mechanism

Authors: Karen V Lithgow, Emily Tsao, Ethan Schovanek, Alloysius Gomez, Leigh Anne Swayne, Caroline E Cameron

Journal: Front Microbiol

PubMed ID: 34354688

Doi: 10.3389/fmicb.2021.691731

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Mitofusion is required for MOTS-c induced GLUT4 translocation

Authors: Khushwant S Bhullar, Nan Shang, Evan Kerek, Kaiyu Wu, Jianping Wu

Journal: Sci Rep

PubMed ID: 34253808

Doi: 10.1038/s41598-021-93735-2

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Overexpression of the Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4 T Cell Activation

Authors: Daniel J Perry, Leeana D Peters, Priya Saikumar Lakshmi, Lin Zhang, Zhao Han, Clive H Wasserfall, Clayton E Mathews, Mark A Atkinson, Todd M Brusko

Journal: J Immunol

PubMed ID: 34301848

Doi: 10.4049/jimmunol.2000708

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Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens

Authors: Jannick Prentoe, Christoph M Janitzek, Rodrigo Velázquez-Moctezuma, Louise Goksøyr, Rebecca W Olsen, Margherita Fanalista, Elias H Augestad, Susan Thrane, Anne F Pihl, Judith M Gottwein, Adam F Sander, Jens Bukh

Journal: PLoS ONE

PubMed ID: 34329365

Doi: 10.1371/journal.pone.0255336

Products & Services: PCR Cloning and Subcloning

Recapture Lysosomal Enzyme Deficiency via Targeted Gene Disruption in the Human Near-Haploid Cell Line HAP1

Authors: Annie Brown, Jiayi Zhang, Brendan Lawler, Biao Lu

Journal: Genes (Basel)

PubMed ID: 34356092

Doi: 10.3390/genes12071076

Products & Services: PCR and Cloning

Heat shock protein 70 attenuates hypoxia‑induced apoptosis of pulmonary microvascular endothelial cells isolated from neonatal rats

Authors: Jing Cao, Lingjie Yang, Le Wang, Qian Zhao, Dian Wu, Mingxia Li, Yuming Mu

Journal: Mol Med Rep

PubMed ID: 34328190

Doi: 10.3892/mmr.2021.12327

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Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson's Disease Models

Authors: Dinesh Kumar Verma, Bo Am Seo, Anurupa Ghosh, Shi-Xun Ma, Karina Hernandez-Quijada, Julie K Andersen, Han Seok Ko, Yong-Hwan Kim

Journal: Cells

PubMed ID: 34359864

Doi: 10.3390/cells10071694

Products & Services: Nucleic Acid Purification & Analysis

LINC00667 Promotes Progression of Esophageal Cancer Cells by Regulating miR-200b-3p/SLC2A3 Axis

Authors: Jindun Pan, Yunhong Zang

Journal: Dig Dis Sci

PubMed ID: 34313922

Doi: 10.1007/s10620-021-07145-5

Products & Services: Mutant Libraries

Long non-coding RNA LINC00607 silencing exerts antioncogenic effects on thyroid cancer through the CASP9 Promoter methylation

Authors: Lanzhen Li, Zhongcheng Gao, Lei Zhao, Peiyou Ren, Hongyan Shen

Journal: J Cell Mol Med

PubMed ID: 34232553

Doi: 10.1111/jcmm.16265

Products & Services: Molecular Biology Reagents

Immunological studies on chicken interferon-kappa using an antigen-capture ELISA developed using new mouse monoclonal antibodies

Authors: Youngsub Lee, Mingmin Lu, Hyun S Lillehoj

Journal: Dev Comp Immunol

PubMed ID: 34271063

Doi: 10.1016/j.dci.2021.104204

Products & Services: Large-Scale Antibody Services

Characterization of CRISPR array in Salmonella enterica from asymptomatic people and patients

Authors: Kai Zhang, Yue Zhang, Zhenyu Wang, Yang Li, Haiyan Xu, Xinan Jiao, Qiuchun Li

Journal: Int J Food Microbiol

PubMed ID: 34333443

Doi: 10.1016/j.ijfoodmicro.2021.109338

Products & Services: DNA Sequencing

Effect of Hydrophobicity and Charge Separation on the Antifouling Properties of Surface-Tethered Zwitterionic Peptides

Authors: Chuanxi Li, Minglun Li, Wei Qi, Rongxin Su, Jing Yu

Journal: Langmuir

PubMed ID: 34228454

Doi: 10.1021/acs.langmuir.1c00803

Products & Services: DNA Sequencing

A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings

Authors: Qifei Li , Michal Dibus , Alicia Casey , Christina S K Yee , Sara O Vargas , Shiyu Luo , Samantha M Rosen, Jill A Madden , Casie A Genetti , Jan Brabek , Catherine A Brownstein , Shideh Kazerounian, Benjamin A Raby , Klaus Schmitz-Abe , John C Kennedy, Martha P Fishman, Mary P Mullen, Joan M Taylor, Daniel Rosel, Pankaj B Agrawal

Journal: PLoS Genet

PubMed ID: 34232960

Doi: 10.1371/journal.pgen.1009639

Products & Services: Mammalian Expression

Eugenol interacts with cardiac sodium channel and reduces heart excitability and arrhythmias

Authors: Jorge Lucas Teixeira-Fonseca, Artur Santos-Miranda, Joab Barbosa da Silva, Leisiane Pereira Marques, Julliane Vasconcelos Joviano-Santos, Paula Idma Chaves Nunes, Danilo Roman-Campos, Antonio Nei Santana Gondim

Journal: Life Sci

PubMed ID: 34217764

Doi: 10.1016/j.lfs.2021.119761

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Downregulation of lncRNA IGF2-AS-encoded peptide induces trophoblast - cycle arrest

Authors: Ai-Hua Wu, Xu-Long Chen, Long-Yi Guo, Dong-Fang Lu, Shan Lu, Ai-Ai Wang, Xue-Fang Liang

Journal: Reprod Biomed Online

PubMed ID: 34474977

Doi: 10.1016/j.rbmo.2021.06.023

Products & Services: Peptide Synthesis

Exploiting Pan Influenza A and Pan Influenza B Pseudotype Libraries for Efficient Vaccine Antigen Selection

Authors: Joanne Marie M Del Rosario, Kelly A S da Costa, Benedikt Asbach, Francesca Ferrara, Matteo Ferrari, David A Wells, Gurdip Singh Mann, Veronica O Ameh, Claude T Sabeta, Ashley C Banyard, Rebecca Kinsley, Simon D Scott, Ralf Wagner, Jonathan L Heeney, George W Carnell, Nigel J Temperton

Journal: Vaccines (Basel)

PubMed ID: 34358157

Doi: 10.3390/vaccines9070741

Products & Services: PCR Cloning and Subcloning

Engineering Concanavalin B to Release Bioactive Peptides against Metabolic Syndrome

Authors: Diego Armando Maldonado-Torres, G Janet Jara-Romero, Flor de Fátima Rosas-Cárdenas, D Alejandro Fernández-Velasco, Silvia Luna-Suárez

Journal: Foods

PubMed ID: 34359424

Doi: 10.3390/foods10071554

Products & Services: PCR Cloning and Subcloning

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis

Authors: Samir Olatunji, Katherine Bowen, Chia-Ying Huang, Dietmar Weichert, Warispreet Singh, Irina G Tikhonova, Eoin M Scanlan, Vincent Olieric, Martin Caffrey

Journal: Nat Commun

PubMed ID: 34253723

Doi: 10.1038/s41467-021-24475-0

Products & Services: Bacterial Expression

A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary

Authors: K Yeon Choi, Alistair McGregor

Journal: Viruses

PubMed ID: 34452332

Doi: 10.3390/v13081467

Products & Services: Mutant Libraries

Structural and Biochemical Characterization of the Flavin-Dependent Siderophore-Interacting Protein from

Authors: Hannah Valentino, David A Korasick, Tabbetha J Bohac, Justin A Shapiro, Timothy A Wencewicz, John J Tanner, Pablo Sobrado

Journal: ACS Omega

PubMed ID: 34308084

Doi: 10.1021/acsomega.1c03047

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Endophilin A2 regulates B-cell endocytosis and is required for germinal center and humoral responses

Authors: Dessislava Malinova, Laabiah Wasim, Rebecca Newman, Ana Martínez-Riaño, Niklas Engels, Pavel Tolar

Journal: EMBO Rep

PubMed ID: 34323351

Doi: 10.15252/embr.202051328

Products & Services: Proteins, Expression, Isolation and Analysis

A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission

Authors: Zhenke Yang, Yang Shi, Huiting Cui, Shuzhen Yang, Han Gao, Jing Yuan

Journal: Sci Adv

PubMed ID: 34301597

Doi: 10.1126/sciadv.abf6015

Products & Services: Proteins, Expression, Isolation and Analysis

Annexin A1 Tripeptide Mimetic Increases Sirtuin-3 and Augments Mitochondrial Function to Limit Ischemic Kidney Injury

Authors: Hagir Suliman, Qing Ma, Zhiquan Zhang, Jiafa Ren, Benjamin T Morris, Steven D Crowley, Luis Ulloa, Jamie R Privratsky

Journal: Front Physiol

PubMed ID: 34276404

Doi: 10.3389/fphys.2021.683098

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WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

Authors: Chunwan Lu, Zhuoqi Liu, John D Klement, Dafeng Yang, Alyssa D Merting, Dakota Poschel, Thomas Albers, Jennifer L Waller, Huidong Shi, Kebin Liu

Journal: J Immunother Cancer

PubMed ID: 34326167

Doi: 10.1136/jitc-2021-002624

Products & Services: Plasmid DNA Preparation

SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects

Authors: Juan Zhao, Ling Wang, Madison Schank, Xindi Dang, Zeyuan Lu, Dechao Cao, Sushant Khanal, Lam N Nguyen, Lam N T Nguyen, Jinyu Zhang, Yi Zhang, James L Adkins, Evan M Baird, Xiao Y Wu, Shunbin Ning, Mohamed El Gazzar, Jonathan P Moorman, Zhi Q Yao

Journal: Virus Res

PubMed ID: 34329696

Doi: 10.1016/j.virusres.2021.198508

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Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury

Authors: Evgeny A Zemskov, Xiaomin Wu, Saurabh Aggarwal, Mannivannan Yegambaram, Christine Gross, Qing Lu, Hui Wang, Haiyang Tang, Ting Wang, Stephen M Black

Journal: J Biol Chem

PubMed ID: 34252457

Doi: 10.1016/j.jbc.2021.100946

Products & Services: Mammalian Expression

Molecular characterization and functional analysis of Trx and Trp14 in roughskin sculpin (Trachidermus fasciatus)

Authors: Yingying Liu, Jinmiao Zhong, Lihua Zhao, Shanshan Yu, Haidong Zha, Yingmei Chai, Qian Zhu

Journal: Fish Physiol Biochem

PubMed ID: 34279744

Doi: 10.1007/s10695-021-00978-x

Products & Services: Proteins, Expression, Isolation and Analysis

An iPSC model of hereditary sensory neuropathy-1 reveals L-serine-responsive deficits in neuronal ganglioside composition and axoglial interactions

Authors: Alex J Clark, Umaiyal Kugathasan, Georgios Baskozos, David A Priestman, Nadine Fugger, Museer A Lone, Alaa Othman, Ka Hing Chu, Iulia Blesneac, Emma R Wilson, Matilde Laurà, Bernadett Kalmar, Linda Greensmith, Thorsten Hornemann, Frances M Platt, Mary M Reilly, David L Bennett

Journal: Cell Rep Med

PubMed ID: 34337561

Doi: 10.1016/j.xcrm.2021.100345

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Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization

Authors: Ariana D Sanchez, Tess C Branon, Lauren E Cote, Alexandros Papagiannakis, Xing Liang, Melissa A Pickett, Kang Shen, Christine Jacobs-Wagner, Alice Y Ting, Jessica L Feldman

Journal: Curr Biol

PubMed ID: 34242576

Doi: 10.1016/j.cub.2021.06.021

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Comparison of promoter, DNA vector, and cationic carrier for efficient transfection of hMSCs from multiple donors and tissue sources

Authors: Tyler Kozisek, Andrew Hamann, Luke Samuelson, Miguel Fudolig, Angela K Pannier

Journal: Mol Ther Nucleic Acids

PubMed ID: 34513295

Doi: 10.1016/j.omtn.2021.06.018

Products & Services: Recombinant Proteins

Targeting the Regulatory Subunit R2Alpha of Protein Kinase A in Human Glioblastoma through shRNA-Expressing Lentiviral Vectors

Authors: Maira Zorzan, Claudia Del Vecchio, Stefania Vogiatzis, Elisa Saccon, Cristina Parolin, Giorgio Palù, Arianna Calistri, Carla Mucignat-Caretta

Journal: Viruses

PubMed ID: 34372567

Doi: 10.3390/v13071361

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Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam

Authors: Nguyen Van Vinh Chau, Le Nguyen Thanh Nhan, Lam Anh Nguyet, Nguyen Thi Kha Tu, Nguyen Thi Thu Hong, Dinh Nguyen Huy Man, Dinh Thi Bich Ty, Le Nguyen Truc Nhu, Lam Minh Yen, Truong Huu Khanh, Du Tuan Quy, Ngo Ngoc Quang Minh, Nguyen Thi Han Ny, Danielle Anderson, Lin-Fa Wang, H Rogier van Doorn, Nguyen Thanh Hung, Tran Tan Thanh, Guy Thwaites, Le Van Tan

Journal: Int J Infect Dis

PubMed ID: 34339862

Doi: 10.1016/j.ijid.2021.07.072

Products & Services: Recombinant Proteins

nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity

Authors: Laura Sandra Lello, Koen Bartholomeeusen, Sainan Wang, Sandra Coppens, Rennos Fragkoudis, Luke Alphey, Kevin K Ariën, Andres Merits, Age Utt

Journal: J Virol

PubMed ID: 34319783

Doi: 10.1128/JVI.00355-21

Products & Services: Proteins, Expression, Isolation and Analysis Gene Synthesis

Oligopaint DNA FISH reveals telomere-based meiotic pairing dynamics in the silkworm, Bombyx mori

Authors: Leah F Rosin, Jose Gil, Ines A Drinnenberg, Elissa P Lei

Journal: PLoS Genet

PubMed ID: 34319984

Doi: 10.1371/journal.pgen.1009700

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Genetic engineering of Treponema pallidum subsp pallidum, the Syphilis Spirochete

Authors: Emily Romeis, Lauren Tantalo, Nicole Lieberman, Quynh Phung, Alex Greninger, Lorenzo Giacani

Journal: PLoS Pathog

PubMed ID: 34228757

Doi: 10.1371/journal.ppat.1009612

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Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors

Authors: Robert Reiberger, Kateřina Radilová, Michal Kráľ, Václav Zima, Pavel Majer, Jiří Brynda, Martin Dračínský, Jan Konvalinka, Milan Kožíšek, Aleš Machara

Journal: Int J Mol Sci

PubMed ID: 34299354

Doi: 10.3390/ijms22147735

Products & Services: PCR and Cloning

LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells

Authors: Zhen Sun, Hua Yu, Jing Zhao, Tianyu Tan, Hongru Pan, Yuqing Zhu, Lang Chen, Cheng Zhang, Li Zhang, Anhua Lei, Yuyan Xu, Xianju Bi, Xin Huang, Bo Gao, Longfei Wang, Cristina Correia, Ming Chen, Qiming Sun, Yu Feng, Li Shen, Hao Wu, Jianlong Wang, Xiaohua Shen, George Q Daley, Hu Li, Jin Zhang

Journal: Protein Cell

PubMed ID: 34331666

Doi: 10.1007/s13238-021-00864-5

Products & Services: Plasmid DNA Preparation

Assessing the antigenicity of different VP3 regions of infectious bursal disease virus in chickens from South Brazil

Authors: Ana Paula Gori Palka, Tatiana Reichert Assunção de Matos, Claudemir de Souza, Danilo Santos Eugênio, Marco Aurélio Krieger, Stenio Perdigão Fragoso, Daniela Parada Pavoni

Journal: BMC Vet Res

PubMed ID: 34330285

Doi: 10.1186/s12917-021-02956-0

Products & Services: Bacterial Expression

Analysis of Evolution, Expression and Genetic Transformation of TCP Transcription Factors in Blueberry Reveal That Negatively Regulates the Release of Flower Bud Dormancy

Authors: Yongqiang Li, Shuang An, Qiangqiang Cheng, Yu Zong, Wenrong Chen, Weidong Guo, Lu Zhang

Journal: Front Plant Sci

PubMed ID: 34305986

Doi: 10.3389/fpls.2021.697609

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Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Authors: Yanyan Wang, Xiaowei Li, Xin Chen, Jens Nielsen, Dina Petranovic, Verena Siewers

Journal: Microb Cell Fact

PubMed ID: 34261490

Doi: 10.1186/s12934-021-01624-0

Products & Services: Codon Optimization

The RNA editing enzyme ADAR2 restricts L1 mobility

Authors: Loredana Frassinelli, Elisa Orecchini, Sofian Al-Wardat, Marco Tripodi, Carmine Mancone, Margherita Doria, Silvia Galardi, Silvia Anna Ciafrè, Alessandro Michienzi

Journal: RNA Biol

PubMed ID: 34224323

Doi: 10.1080/15476286.2021.1940020

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The disordered PCI-binding human proteins CSNAP and DSS1 have diverged in structure and function

Authors: Sarah F Ruidiaz, Jesper E Dreier, Rasmus Hartmann-Petersen, Birthe B Kragelund

Journal: Protein Sci

PubMed ID: 34272906

Doi: 10.1002/pro.4159

Products & Services: Mammalian Expression

VC1 catalyses a key step in the biosynthesis of vicine in faba bean

Authors: Emilie Björnsdotter, Marcin Nadzieja, Wei Chang, Leandro Escobar-Herrera, Davide Mancinotti, Deepti Angra, Xinxing Xia, Rebecca Tacke, Hamid Khazaei, Christoph Crocoll, Albert Vandenberg, Wolfgang Link, Frederick L Stoddard, Donal M O'Sullivan, Jens Stougaard, Alan H Schulman, Stig U Andersen, Fernando Geu-Flores

Journal: Nat Plants

PubMed ID: 34226693

Doi: 10.1038/s41477-021-00950-w

Products & Services: Bacterial Expression

Function of cofactor Akirin2 in the regulation of gene expression in model human Caucasian neutrophil-like HL60 cells

Authors: Sara Artigas-Jerónimo, Margarita Villar, Agustín Estrada-Peña, Adrián Velázquez-Campoy, Pilar Alberdi, José de la Fuente

Journal: Biosci Rep

PubMed ID: 34291801

Doi: 10.1042/BSR20211120

Products & Services: Mammalian Expression

SARS-CoV-2 Neutralizing Antibody Responses towards Full-Length Spike Protein and the Receptor-Binding Domain

Authors: Rafael Bayarri-Olmos, Manja Idorn, Anne Rosbjerg, Laura Pérez-Alós, Cecilie Bo Hansen, Laust Bruun Johnsen, Charlotte Helgstrand, Franziska Zosel, Jais Rose Bjelke, Fredrik Kryh Öberg, Max Søgaard, Søren R Paludan, Theresa Bak-Thomsen, Joseph G Jardine, Mikkel-Ole Skjoedt, Peter Garred

Journal: J Immunol

PubMed ID: 34301847

Doi: 10.4049/jimmunol.2100272

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides

Authors: Lawrence M Schopfer, Seda Onder, Oksana Lockridge

Journal: PLoS ONE

PubMed ID: 34242352

Doi: 10.1371/journal.pone.0254450

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Kinetics of Anti-SARS-CoV-2 Antibody Responses 3 Months Post Complete Vaccination with BNT162b2; A Prospective Study in 283 Health Workers

Authors: Evangelos Terpos, Ioannis P Trougakos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Sentiljana Gumeni, Filia Apostolakou, Aimilia D Sklirou, Maria Gavriatopoulou, Stamatia Skourti, Efstathios Kastritis, Eleni Korompoki, Ioannis Papassotiriou, Meletios A Dimopoulos

Journal: Cells

PubMed ID: 34440710

Doi: 10.3390/cells10081942

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases

Authors: Tess R Malcolm, Karolina W Swiderska, Brooke K Hayes, Chaille T Webb, Marcin Drag, Nyssa Drinkwater, Sheena McGowan

Journal: Biochem J

PubMed ID: 34133730

Doi: 10.1042/BCJ20210172

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Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases

Authors: Tess R Malcolm, Karolina W Swiderska, Brooke K Hayes, Chaille T Webb, Marcin Drag, Nyssa Drinkwater, Sheena McGowan

Journal: Biochem J

PubMed ID: 34133730

Doi: 10.1042/BCJ20210172

Products & Services: Gene Synthesis

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