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Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease

Authors: Shanshan Li, Kan-Yen Hsieh, Shih-Chieh Su, Grigore D Pintilie, Kaiming Zhang, Chung-I Chang

Journal: J Biol Chem

PubMed ID: 34563541

Doi: 10.1016/j.jbc.2021.101239

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Structural insights into the activation of human calcium-sensing receptor

Authors: Xiaochen Chen, Lu Wang, Qianqian Cui, Zhanyu Ding, Li Han, Yongjun Kou, Wenqing Zhang, Haonan Wang, Xiaomin Jia, Mei Dai, Zhenzhong Shi, Yuying Li, Xiyang Li, Yong Geng

Journal: Elife

PubMed ID: 34467854

Doi: 10.7554/eLife.68578

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Neuromedin B receptor stimulation of Cav32 T-type Ca channels in primary sensory neurons mediates peripheral pain hypersensitivity

Authors: Yuan Zhang, Zhiyuan Qian, Dongsheng Jiang, Yufang Sun, Shangshang Gao, Xinghong Jiang, Hua Wang, Jin Tao

Journal: Theranostics

PubMed ID: 34646374

Doi: 10.7150/thno.62255

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Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis

Authors: Fredarla S Miller, Kathryn K Crone, Matthew R Jensen, Sudipta Shaw, William R Harcombe, Mikael H Elias, Michael F Freeman

Journal: Nat Commun

PubMed ID: 34504067

Doi: 10.1038/s41467-021-25575-7

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Cellular retinoid-binding proteins transfer retinoids to human cytochrome P450 27C1 for desaturation

Authors: Sarah M Glass, F Peter Guengerich

Journal: J Biol Chem

PubMed ID: 34480899

Doi: 10.1016/j.jbc.2021.101142

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Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease

Authors: Kevin J Roberts, Marion F Cubitt, Timothy M Carlton, Lurdes Rodrigues-Duarte, Luana Maggiore, Ray Chai, Simon Clare, Katherine Harcourt, Thomas T MacDonald, Keith P Ray, Anna Vossenkämper, Michael R West, J Scott Crowe

Journal: Sci Rep

PubMed ID: 34593832

Doi: 10.1038/s41598-021-97236-0

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Newt regeneration genes regulate Wingless signaling to restore patterning in eye

Authors: Abijeet Singh Mehta, Prajakta Deshpande, Anuradha Venkatakrishnan Chimata, Panagiotis A Tsonis, Amit Singh

Journal: iScience

PubMed ID: 34746690

Doi: 10.1016/j.isci.2021.103166

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Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens

Authors: Brandi T Johnson-Weaver, Hae Woong Choi, Hang Yang, Josh A Granek, Cliburn Chan, Soman N Abraham, Herman F Staats

Journal: Front Immunol

PubMed ID: 34566991

Doi: 10.3389/fimmu.2021.730346

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Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra

Authors: Salinthip Jarusintanakorn, Chutima Phechkrajang, Putthiporn Khongkaew, Enrico Mastrobattista, Montarop Yamabhai

Journal: Anal Bioanal Chem

PubMed ID: 34476523

Doi: 10.1007/s00216-021-03549-4

Products & Services: Protein and Antibody Isolation

Ferulic Acid Metabolites Attenuate LPS-Induced Inflammatory Response in Enterocyte-like Cells

Authors: Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana

Journal: Nutrients

PubMed ID: 34579029

Doi: 10.3390/nu13093152

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Manipulating turn residues on de novo designed β-hairpin peptides for selectivity against drug-resistant bacteria

Authors: Nhan D T Tram, Vanitha Selvarajan, Alister Boags, Devika Mukherjee, Jan K Marzinek, Bernadette Cheng, Zi-Chen Jiang, Pascal Goh, Jun-Jie Koh, Jeanette W P Teo, Peter J Bond, Pui Lai Rachel Ee

Journal: Acta Biomater

PubMed ID: 34506975

Doi: 10.1016/j.actbio.2021.09.004

Products & Services: Molecular Biology Tools

A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82

Authors: Houyu Ju, Zhenrong Hu, Dongliang Wei, Jinyun Huang, Xinyi Zhang, Mengyu Rui, Zhi Li, Xiaomeng Zhang, Jingzhou Hu, Wei Guo, Guoxin Ren

Journal: Cancer Commun (Lond)

PubMed ID: 34498800

Doi: 10.1002/cac2.12213

Products & Services: Plasmid DNA Preparation

Development and characterization of a unique anti-IgE mouse monoclonal antibody cross-reactive between human and canine IgE

Authors: Akiko Kumagai, Takuya Nara, Mizuho Uematsu, Yoko Kakinuma, Takashi Saito, Kenichi Masuda

Journal: Immun Inflamm Dis

PubMed ID: 34533288

Doi: 10.1002/iid3.531

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Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3

Authors: Sean L Johnson, Kozeta Libohova, Jessica R Blount, Alyson L Sujkowski, Matthew V Prifti, Wei-Ling Tsou, Sokol V Todi

Journal: Neurobiol Dis

PubMed ID: 34563642

Doi: 10.1016/j.nbd.2021.105516

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Structure and function of aerotolerant, multiple-turnover THI4 thiazole synthases

Authors: Jaya Joshi, Qiang Li, Jorge D García-García, Bryan J Leong, You Hu, Steven D Bruner, Andrew D Hanson

Journal: Biochem J

PubMed ID: 34409984

Doi: 10.1042/BCJ20210565

Products & Services: Bacterial Expression

Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6

Authors: Shuang Zhang, Sihan Lin, Qiaofei Tang, Zhiyong Yan

Journal: Mol Med Rep

PubMed ID: 34558634

Doi: 10.3892/mmr.2021.12458

Products & Services: Mutant Libraries

Transcriptome Reprogramming of Tomato Orchestrate the Hormone Signaling Network of Systemic Resistance Induced by

Authors: Jagmohan Singh, Rashmi Aggarwal, Bishnu Maya Bashyal, K Darshan, Pooja Parmar, M S Saharan, Zakir Hussain, Amolkumar U Solanke

Journal: Front Plant Sci

PubMed ID: 34630468

Doi: 10.3389/fpls.2021.721193

Products & Services: Molecular Biology Tools

Precise Characterization of Gene Using Cpf1-Based Enrichment and Oxford Nanopore Technologies

Authors: Wei Lu, Xinhui Lan, Tong Zhang, Hao Sun, Sanyuan Ma, Qingyou Xia

Journal: Insects

PubMed ID: 34564273

Doi: 10.3390/insects12090832

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A Plant-Produced Virus-Like Particle Displaying Envelope Protein Domain III Elicits an Immune Response Against West Nile Virus in Mice

Authors: Jennifer Stander, Aleyo Chabeda, Edward P Rybicki, Ann E Meyers

Journal: Front Plant Sci

PubMed ID: 34589108

Doi: 10.3389/fpls.2021.738619

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Immunoprotection evaluation of the recombinant N-terminal domain of Cys-loop receptors against Rhipicephalus (Boophilus) microplus tick infestation

Authors: Moisés Martínez Velázquez, Carla Patricia Barragán Álvarez, José Miguel Flores Fernández, Rodolfo Esteban Lagunes Quintanilla, Edgar Castro Saines, Patricia Berenice Ramírez Rodríguez, Sara Elisa Herrera Rodríguez, Rodolfo Hernández Gutiérrez, Abel Gutiérrez Ortega, Ángel H Álvarez

Journal: Parasite

PubMed ID: 34533454

Doi: 10.1051/parasite/2021064

Products & Services: Plasmid DNA Preparation

Rapid antibody testing for SARS-CoV-2 vaccine response in pediatric healthcare workers

Authors: Theodore W Heyming, Diane Nugent, Aprille Tongol, Chloe Knudsen-Robbins, Janet Hoang, John Schomberg, Kellie Bacon, Bryan Lara, Terence Sanger

Journal: Int J Infect Dis

PubMed ID: 34601142

Doi: 10.1016/j.ijid.2021.09.065

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Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8 T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma

Authors: Hailin Zhang, Yonghui Zhang, Jie Dong, Shuguang Zuo, Gang Meng, Junhua Wu, Jiwu Wei

Journal: Cell Oncol (Dordr)

PubMed ID: 34491549

Doi: 10.1007/s13402-021-00633-w

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Novel Homologs of Isopentenyl Phosphate Kinase Reveal Class-Wide Substrate Flexibility

Authors: Vikas Kumar , Bryce P Johnson , Dustin A Dimas , Shanteri Singh

Journal: ChemCatChem

PubMed ID: 34630731

Doi: 10.1002/cctc.202100595

Products & Services: Gene Synthesis

Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to confer full host defense against tospovirus infection

Authors: Hongyu Chen , Xin Qian , Xiaojiao Chen , Tongqing Yang , Mingfeng Feng , Jing Chen , Ruixiang Cheng , Hao Hong , Ying Zheng , Yuzhen Mei , Danyu Shen , Yi Xu , Min Zhu , Xin Shun Ding , Xiaorong Tao

Journal: New Phytol

PubMed ID: 34096619

Doi: 10.1111/nph.17535

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Assessment of IsPETase-Assisted Depolymerization of Terephthalate Aromatic Polyesters and the Effect of the Thioredoxin Fusion Domain

Authors: Paula Wagner-Egea ,Virginia Tosi ,Ping Wang ,Carl Grey,Baozhong Zhang and Javier A. Linares-Pastén

Journal: applied sciences

Doi: 10.3390/app11188315

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Structure-Function Analysis and Redox Interactomes of Leishmania tarentolae Erv

Authors: Gino L Turra, Linda Liedgens, Frederik Sommer, Luzia Schneider, David Zimmer, Jordi Vilurbina Perez, Sasa Koncarevic, Michael Schroda, Timo Mühlhaus, Marcel Deponte

Journal: Microbiol Spectr

PubMed ID: 34585988

Doi: 10.1128/Spectrum.00809-21

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One Health Investigation of SARS-CoV-2 Infection and Seropositivity among Pets in Households with Confirmed Human COVID-19 Cases-Utah and Wisconsin, 2020

Authors: Grace W Goryoka, Caitlin M Cossaboom, Radhika Gharpure, Patrick Dawson, Cassandra Tansey, John Rossow, Victoria Mrotz, Jane Rooney, Mia Torchetti, Christina M Loiacono, Mary L Killian, Melinda Jenkins-Moore, Ailam Lim, Keith Poulsen, Dan Christensen, Emma Sweet, Dallin Peterson, Anna L Sangster, Erin L Young, Kelly F Oakeson, Dean Taylor, Amanda Price, Tair Kiphibane, Rachel Klos, Darlene Konkle, Sanjib Bhattacharyya, Trivikram Dasu, Victoria T Chu, Nathaniel M Lewis, Krista Queen, Jing Zhang, Anna Uehara, Elizabeth A Dietrich, Suxiang Tong, Hannah L Kirking, Jeffrey B Doty, Laura S Murrell, Jessica R Spengler, Anne Straily, Ryan Wallace, Casey Barton Behravesh

Journal: Viruses

PubMed ID: 34578394

Doi: 10.3390/v13091813

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Profiles of spp Isolated from the Rhizosphere of Suaeda glauca and Their Potential to Promote Plant Growth and Suppress Fungal Phytopathogens

Authors: Ping Lu, Ke Jiang, Ya-Qiao Hao, Wan-Ying Chu, Yu-Dong Xu, Jia-Yao Yang, Jia-Le Chen, Guo-Hong Zeng, Zhou-Hang Gu, Hong-Xin Zhao

Journal: J Microbiol Biotechnol

PubMed ID: 34261851

Doi: 10.4014/jmb.2105.05010

Products & Services: Recombinant Antibody Expression

Highly Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA

Authors: Eva Piano Mortari, Cristina Russo, Maria Rosaria Vinci, Sara Terreri, Ane Fernandez Salinas, Livia Piccioni, Claudia Alteri, Luna Colagrossi, Luana Coltella, Stefania Ranno, Giulia Linardos, Marilena Agosta, Christian Albano, Chiara Agrati, Concetta Castilletti, Silvia Meschi, Paolo Romania, Giuseppe Roscilli, Emiliano Pavoni, Vincenzo Camisa, Annapaola Santoro, Rita Brugaletta, Nicola Magnavita, Alessandra Ruggiero, Nicola Cotugno, Donato Amodio, Marta Luisa Ciofi Degli Atti, Daniela Giorgio, Nicoletta Russo, Guglielmo Salvatori, Tiziana Corsetti, Franco Locatelli, Carlo Federico Perno, Salvatore Zaffina, Rita Carsetti

Journal: Cells

PubMed ID: 34685521

Doi: 10.3390/cells10102541

Products & Services: Recombinant Antibody Expression

Structures of foot-and-mouth disease virus with bovine neutralizing antibodies reveal the determinant of intra-serotype cross-neutralization

Authors: Yong He, Kun Li, Li Wang, Zixian Sun, Yimei Cao, Pinghua Li, Pu Sun, Huifang Bao, Shasha Zhou, Sheng Wang, Xingwen Bai, Xuerong Liu, Lixia Zhao, Xiuli Fan, Zaixin Liu, Zengjun Lu, Cheng Yang, Zhiyong Lou

Journal: J Virol

PubMed ID: 34586859

Doi: 10.1128/JVI.01308-21

Products & Services: Protein and Antibody Isolation

Biocatalytic synthesis of 2-O-α-D-glucopyranosyl-L-ascorbic acid using an extracellular expressed α-glucosidase from Oryza sativa

Authors: Xuelian Qi, Junlan Shao, Yinchu Cheng, Xiaoying He, Yan Li, Honghua Jia, Ming Yan

Journal: Biotechnol J

PubMed ID: 34392609

Doi: 10.1002/biot.202100199

Products & Services: Protein and Antibody Isolation

Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module

Authors: Kayleigh M Voos, Wenpeng Cao, Nicholas A Arce, Emily R Legan, Yingchun Wang, Asif Shajahan, Parastoo Azadi, Pete Lollar, Xiaohui Frank Zhang, Renhao Li

Journal: J Thromb Haemost

PubMed ID: 34529349

Doi: 10.1111/jth.15528

Products & Services: Protein and Antibody Isolation

Up-regulation of MELK by E2F1 promotes the proliferation in cervical cancer cells

Authors: Hongzhi Sun, Hongmei Ma, Hao Zhang, Minjun Ji

Journal: Int J Biol Sci

PubMed ID: 34671205

Doi: 10.7150/ijbs.62517

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Finding Ways to Relax: A Revisionistic Analysis of the Chemistry of GTP Cyclohydrolase II

Authors: Madison M Smith, Brett A Beaupre, Dariush C Fourozesh, Kathleen M Meneely, Audrey L Lamb, Graham R Moran

Journal: Biochemistry

PubMed ID: 34569786

Doi: 10.1021/acs.biochem.1c00511

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Identifying Distinct Structural Features of the SARS-CoV-2 Spike Protein Fusion Domain Essential for Membrane Interaction

Authors: Daniel Birtles, Jinwoo Lee

Journal: Biochemistry

PubMed ID: 34570469

Doi: 10.1021/acs.biochem.1c00543

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LvCPG2 facilitated WSSV infection by interaction with VP26 and VP28

Authors: Xing-Chao Ren, Qing-Hui Liu

Journal: Fish Shellfish Immunol

PubMed ID: 34562580

Doi: 10.1016/j.fsi.2021.09.019

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Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in

Authors: Serena Bettoni, Karolina Maziarz, M Rhia L Stone, Mark A T Blaskovich, Jan Potempa, Maria Luiza Bazzo, Magnus Unemo, Sanjay Ram, Anna M Blom

Journal: Front Immunol

PubMed ID: 34539665

Doi: 10.3389/fimmu.2021.726801

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Evolutionary study of maize dwarf mosaic virus using nearly complete genome sequences acquired by next-generation sequencing

Authors: Dulanjani Wijayasekara, Akhtar Ali

Journal: Sci Rep

PubMed ID: 34552152

Doi: 10.1038/s41598-021-98299-9

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Adipokinetic hormone (AKH), energy budget and their effect on feeding and gustatory processes of foraging honey bees

Authors: Gabriela de Brito Sanchez, Anna Expósito Muñoz, Li Chen, Weifone Huang, Songkun Su, Martin Giurfa

Journal: Sci Rep

PubMed ID: 34526585

Doi: 10.1038/s41598-021-97851-x

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Effect of γ-aminobutyric Acid on Phenolics Metabolism in Barley Seedlings under Low NaCl Treatment

Authors: Mian Wang, Yahui Zhu, Pei Wang, Zhenxin Gu, Runqiang Yang

Journal: Antioxidants (Basel)

PubMed ID: 34573053

Doi: 10.3390/antiox10091421

Products & Services: Nucleic Acid Purification

Probing multiple enzymatic methylation events in real time with NMR spectroscopy

Authors: Emery T Usher, Kevin E W Namitz, Michael S Cosgrove, Scott A Showalter

Journal: Biophys J

PubMed ID: 34592262

Doi: 10.1016/j.bpj.2021.09.034

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Single-molecule optical tweezers reveals folding steps of the domain swapping mechanism of a protein

Authors: Andres Bustamante, Rodrigo Rivera, Martin Floor, Jorge Babul, Mauricio Baez

Journal: Biophys J

PubMed ID: 34555362

Doi: 10.1016/j.bpj.2021.09.026

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TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Authors: Tsz-Yin Chan, Christina M Egbert, Julia E Maxson, Adam Siddiqui, Logan J Larsen, Kristina Kohler, Eranga Roshan Balasooriya, Katie L Pennington, Tsz-Ming Tsang, Madison Frey, Erik J Soderblom, Huimin Geng, Markus Müschen, Tetyana V Forostyan, Savannah Free, Gaelle Mercenne, Courtney J Banks, Jonard Valdoz, Clifford J Whatcott, Jason M Foulks, David J Bearss, Thomas O'Hare, David C S Huang, Kenneth A Christensen, James Moody, Steven L Warner, Jeffrey W Tyner, Joshua L Andersen

Journal: Nat Commun

PubMed ID: 34504101

Doi: 10.1038/s41467-021-25622-3

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Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia

Authors: Reina Bassil, Kenneth Shields, Kevin Granger, Ivan Zein, Shirley Ng, Ben Chih

Journal: Nat Commun

PubMed ID: 34471104

Doi: 10.1038/s41467-021-25344-6

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Generation of stable cell lines using readthrough expression from lentiviral integration

Authors: Anish Jadav, Kevin Truong

Journal: Biotechnol Lett

PubMed ID: 34533680

Doi: 10.1007/s10529-021-03186-y

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Expression of the ISPpu9 transposase of Pseudomonas putida KT2440 is regulated by two small RNAs and the secondary structure of the mRNA 5'-untranslated region

Authors: Guillermo Gómez-García, Angel Ruiz-Enamorado, Luis Yuste, Fernando Rojo, Renata Moreno

Journal: Nucleic Acids Res

PubMed ID: 34379788

Doi: 10.1093/nar/gkab672

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Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis

Authors: Bin Wei, Ya-Kun Wang, Jin-Biao Yu, Si-Jia Wang, Yan-Lei Yu, Xue-Wei Xu, Hong Wang

Journal: J Microbiol

PubMed ID: 34554454

Doi: 10.1007/s12275-021-1292-4

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Viral suppressor of RNA silencing in vascular plants also interferes with the development of the bryophyte Physcomitrella patens

Authors: Eeva M Marttinen, Mikko T Lehtonen, Nico van Gessel, Ralf Reski, Jari P T Valkonen

Journal: Plant Cell Environ

PubMed ID: 34564869

Doi: 10.1111/pce.14194

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DcCCD4 catalyzes the degradation of α-carotene and β-carotene to affect carotenoid accumulation and taproot color in carrot

Authors: Tong Li, Yuan-Jie Deng, Jie-Xia Liu, Ao-Qi Duan, Hui Liu, Ai-Sheng Xiong

Journal: Plant J

PubMed ID: 34547154

Doi: 10.1111/tpj.15498

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Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice

Authors: Sawsan S Alamri, Khalid A Alluhaybi, Rowa Y Alhabbab, Mohammad Basabrain, Abdullah Algaissi, Sarah Almahboub, Mohamed A Alfaleh, Turki S Abujamel, Wesam H Abdulaal, M-Zaki ElAssouli, Rahaf H Alharbi, Mazen Hassanain, Anwar M Hashem

Journal: Front Microbiol

PubMed ID: 34557174

Doi: 10.3389/fmicb.2021.727455

Products & Services: DNA Sequencing