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Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion

Authors: Silvia Martinelli, Elmira A Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E Heinz, Tim Ebert, Jakob Hartmann, Thomas M Geiger, Michael Döngi, Kathrin Hafner, Max L Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W Turck, Mathias V Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C Gassen

Journal: Nat Commun

PubMed ID: 34330919

Doi: 10.1038/s41467-021-24810-5

Differential Serotonin Uptake Mechanisms at the Human Maternal-Fetal Interface

Authors: Petra Baković, Maja Kesić, Maja Perić, Ivona Bečeheli, Marina Horvatiček, Meekha George, Lipa Čičin-Šain, Gernot Desoye, Christian Wadsack, Ute Panzenboeck, Jasminka Štefulj

Journal: Int J Mol Sci

PubMed ID: 34360573

Doi: 10.3390/ijms22157807

Products & Services: ORF cDNA Clones/MolecularCloud

Investigating the conformational dynamics of SARS-CoV-2 NSP6 protein with emphasis on non-transmembrane 91-112 & 231-290 regions

Authors: Amit Kumar, ProfilePrateek Kumar, Kumar Udit Saumya, ProfileRajanish Giri

Journal: biorxiv

Doi: doi.org/10.1101/2021.07.06.451329

Products & Services: Peptide Synthesis

Two Inhibitors Against the 3C-Like Proteases of Swine Coronavirus and Feline Coronavirus

Authors: Mengxin Zhou, Yutong Han, Mengxia Li, Gang Ye, Guiqing Peng

Journal: Virol Sin

PubMed ID: 34228261

Doi: 10.1007/s12250-021-00415-6

Products & Services: Peptide Synthesis

Functional Characterization of Ecdysis Triggering Hormone Receptors (AgETHR-A and AgETHR-B) in the African Malaria Mosquito,

Authors: Vikas Jindal, Yoonseong Park, Donghun Kim

Journal: Front Physiol

PubMed ID: 34295267

Doi: 10.3389/fphys.2021.702979

Products & Services: Recombinant Proteins

Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays

Authors: Anton M Sholukh, Andrew Fiore-Gartland, Emily S Ford, Maurine D Miner, Yixuan J Hou, Longping V Tse, Hannah Kaiser, Haiying Zhu, Joyce Lu, Bhanupriya Madarampalli, Arnold Park, Florian A Lempp, Russell St Germain, Emily L Bossard, Jia Jin Kee, Kurt Diem, Andrew B Stuart, Peter B Rupert, Chance Brock, Matthew Buerger, Margaret K Doll, April Kaur Randhawa, Leonidas Stamatatos, Roland K Strong, Colleen McLaughlin, Meei-Li Huang, Keith R Jerome, Ralph S Baric, David Montefiori, Lawrence Corey

Journal: J Clin Microbiol

PubMed ID: 34288726

Doi: 10.1128/JCM.00527-21

Products & Services: Recombinant Proteins

Simultaneous Removal of the Freshwater Bloom-Forming Cyanobacterium and Cyanotoxin Microcystins via Combined Use of Algicidal Bacterial Filtrate and the Microcystin-Degrading Enzymatic Agent, MlrA

Authors: Suqin Wang, Siyu Yang, Jun Zuo, Chenlin Hu, Lirong Song, Nanqin Gan, Peng Chen

Journal: Microorganisms

PubMed ID: 34442673

Doi: 10.3390/microorganisms9081594

Products & Services: Proteins, Expression, Isolation and Analysis

Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus

Authors: Matthew K H Wong, Yuan Chen, Mulan He, Chengyuan Lin, Zhaoxiang Bian, Anderson O L Wong

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34276562

Doi: 10.3389/fendo.2021.681647

Products & Services: Proteins, Expression, Isolation and Analysis

Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway

Authors: Wencui Wan, Wei Zhu, Yan Wu, Yang Long, Hongzhuo Liu, Weiwei Wan, Guangming Wan, Jing Yu

Journal: J Inflamm Res

PubMed ID: 34285539

Doi: 10.2147/JIR.S306456

Products & Services: PCR and Cloning

GhKWL1 Upregulates but Its Function Is Impaired by Binding with VdISC1, a Pathogenic Effector of

Authors: Yang Chen, Mi Zhang, Lei Wang, Xiaohan Yu, Xianbi Li, Dan Jin, Jianyan Zeng, Hui Ren, Fanlong Wang, Shuiqing Song, Xingying Yan, Juan Zhao, Yan Pei

Journal: Int J Mol Sci

PubMed ID: 34298948

Doi: 10.3390/ijms22147328

Products & Services: Protein Tools

The DUB family in Populus: identification, characterization, evolution and expression patterns

Authors: Wenqing Zheng, Liang Du

Journal: BMC Genomics

PubMed ID: 34266381

Doi: 10.1186/s12864-021-07844-3

Products & Services: Protein Tools

The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase

Authors: Ankoor Patel, Jessica A M McBride, Brian L Mark

Journal: J Biol Chem

PubMed ID: 34265303

Doi: 10.1016/j.jbc.2021.100957

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Comprehensive Characterization of Universal Stress Proteins in Rice ( L) With Insight Into Their Stress-Specific Transcriptional Modulation

Authors: Shatil Arabia, Asif Ahmed Sami, Saima Akhter, Rakha Hari Sarker, Tahmina Islam

Journal: Front Plant Sci

PubMed ID: 34394169

Doi: 10.3389/fpls.2021.712607

Products & Services: Protein Tools

WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation

Authors: Yvonne Xinyi Lim, Hexian Lin, Tinghine Chu, Yoon Pin Lim

Journal: Mol Oncol

PubMed ID: 34197030

Doi: 10.1002/1878-0261.13048

Products & Services: Recombinant Proteins

Development of a Platform for Noncovalent Coupling of Full Antigens to Tobacco Etch Virus-Like Particles by Means of Coiled-Coil Oligomerization Motifs

Authors: Lorena Zapata-Cuellar, Jorge Gaona-Bernal, Carlos Alberto Manuel-Cabrera, Moisés Martínez-Velázquez, Carla Sánchez-Hernández, Darwin Elizondo-Quiroga, Tanya Amanda Camacho-Villegas, Abel Gutiérrez-Ortega

Journal: Molecules

PubMed ID: 34361589

Doi: 10.3390/molecules26154436

Products & Services: Bacterial Expression

Melioidosis Patient Survival Correlates With Strong IFN-γ Secreting T Cell Responses Against Hcp1 and TssM

Authors: Sineenart Sengyee, Atchara Yarasai, Rachan Janon, Chumpol Morakot, Orawan Ottiwet, Lindsey K Schmidt, T Eoin West, Mary N Burtnick, Narisara Chantratita, Paul J Brett

Journal: Front Immunol

PubMed ID: 34394091

Doi: 10.3389/fimmu.2021.698303

Products & Services: GenParts™ DNA Fragments

CCR2 Regulates Vaccine-Induced Mucosal T-Cell Memory to Influenza A Virus

Authors: Woojong Lee, Brock Kingstad-Bakke, Ross M Kedl, Yoshihiro Kawaoka, M Suresh

Journal: J Virol

PubMed ID: 33952647

Doi: 10.1128/JVI.00530-21

Products & Services: Mammalian Expression

In Silico Target Prediction of Overexpressed microRNAs from LPS-Challenged Zebrafish () Treated with the Novel Anti-Inflammatory Peptide P

Authors: Geonildo R Disner, Maria A P Falcão, Carla Lima, Monica Lopes-Ferreira

Journal: Int J Mol Sci

PubMed ID: 34281170

Doi: 10.3390/ijms22137117

Products & Services: Proteins, Expression, Isolation and Analysis

Candida albicans and Candida glabrata triosephosphate isomerase - a moonlighting protein that can be exposed on the candidal cell surface and bind to human extracellular matrix proteins

Authors: Dorota Satala, Grzegorz Satala, Marcin Zawrotniak, Andrzej Kozik

Journal: BMC Microbiol

PubMed ID: 34210257

Doi: 10.1186/s12866-021-02235-w

Products & Services: GenParts™ DNA Fragments

African Swine Fever Virus CD2v Protein Induces β-Interferon Expression and Apoptosis in Swine Peripheral Blood Mononuclear Cells

Authors: Sabal Chaulagain, Gustavo A Delhon, Sushil Khatiwada, Daniel L Rock

Journal: Viruses

PubMed ID: 34452346

Doi: 10.3390/v13081480

Products & Services: Gene Synthesis

Species-specific gamete recognition initiates fusion-driving trimer formation by conserved fusogen HAP2

Authors: Jun Zhang, Jennifer F Pinello, Ignacio Fernández, Eduard Baquero, Juliette Fedry, Félix A Rey, William J Snell

Journal: Nat Commun

PubMed ID: 34282138

Doi: 10.1038/s41467-021-24613-8

Products & Services: Gene Synthesis

Genome-wide identification of heat shock transcription factors and potential role in regulation of antioxidant response under hot water and glycine betaine treatments in cold-stored peaches

Authors: Li Wang, Yuanyuan Hou, Yi Wang, Shunqing Hu, Yonghua Zheng, Peng Jin

Journal: J Sci Food Agric

PubMed ID: 34146341

Doi: 10.1002/jsfa.11392

Products & Services: Protein Tools

The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity

Authors: Yisheng He, Jiang Ma, Xiaoyu Fan, Liang Ding, Xinxin Ding, Qing-Yu Zhang, Ge Lin

Journal: Acta Pharm Sin B

PubMed ID: 35024309

Doi: 10.1016/j.apsb.2021.07.013

Products & Services: Endotoxin Detection & Removal System

Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer's disease

Authors: Christina F de Veij Mestdagh, Jaap A Timmerman, Frank Koopmans, Iryna Paliukhovich, Suzanne S M Miedema, Maaike Goris, Rolinka J van der Loo, Guido Krenning, Ka Wan Li, Huibert D Mansvelder, August B Smit, Robert H Henning, Ronald E van Kesteren

Journal: Sci Rep

PubMed ID: 34326412

Doi: 10.1038/s41598-021-94992-x

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Human cell transformation by combined lineage conversion and oncogene expression

Authors: Biswajyoti Sahu, Päivi Pihlajamaa, Kaiyang Zhang, Kimmo Palin, Saija Ahonen, Alejandra Cervera, Ari Ristimäki, Lauri A Aaltonen, Sampsa Hautaniemi, Jussi Taipale

Journal: Oncogene

PubMed ID: 34302118

Doi: 10.1038/s41388-021-01940-0

Products & Services: DNA Sequencing

Tumor-promoting function of PIMREG in glioma by activating the β-catenin pathway

Authors: Dekang Wang, Aili Hu, Hao Peng, Dongbo Li, Li Zhang

Journal: 3 Biotech

PubMed ID: 34458056

Doi: 10.1007/s13205-021-02922-5

Products & Services: DNA Sequencing

A 5'-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer

Authors: Litao Han, Hejing Lai, Yichen Yang, Jiaqian Hu, Zhe Li, Ben Ma, Weibo Xu, Wanlin Liu, Wenjun Wei, Duanshu Li, Yu Wang, Qiwei Zhai, Qinghai Ji, Tian Liao

Journal: J Exp Clin Cancer Res

PubMed ID: 34225773

Doi: 10.1186/s13046-021-02024-3

Products & Services: DNA Sequencing

PDIA6 promotes pancreatic cancer progression and immune escape through CSN5-mediated deubiquitination of β-catenin and PD-L1

Authors: Yihui Ma, Peiyi Xia, Zhengyang Wang, Jingjing Xu, Lan Zhang, Yanan Jiang

Journal: Neoplasia

PubMed ID: 34325342

Doi: 10.1016/j.neo.2021.07.004

Products & Services: Custom Vector Construction

Chemical Synthesis of the Sec-To-Cys Homologue of Human Selenoprotein F and Elucidation of Its Disulfide-pairing Mode

Authors: Peisi Liao, Chunmao He

Journal: Front Chem

PubMed ID: 34395389

Doi: 10.3389/fchem.2021.735149

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Transcriptional activation of ENPP2 by FoxO4 protects cardiomyocytes from doxorubicin‑induced toxicity

Authors: Ling He, Yuting Yang, Juan Chen, Pengtao Zou, Juxiang Li

Journal: Mol Med Rep

PubMed ID: 34296293

Doi: 10.3892/mmr.2021.12307

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Functional Expression of a Mo-Cu-Dependent Carbon Monoxide Dehydrogenase (CODH) and Its Use as a Dissolved CO Bio-microsensor

Authors: Stacy Simai Reginald, Michael Etzerodt, Deby Fapyane, In Seop Chang

Journal: ACS Sens

PubMed ID: 34253013

Doi: 10.1021/acssensors.1c01243

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Hsa_circ_0008360 sponges miR-186-5p to target CCND2 to modulate high glucose-induced vascular endothelial dysfunction

Authors: Qian-Qian Zhu, Xi-Bin Pu, Tian-Chi Chen, Chen-Yang Qiu, Zi-Heng Wu, Lu Tian, Yang-Yan He, Xiao-Hui Wang, Tao Shang, Xun Wang, Yi-Lang Xiang, Dong-Lin Li, Hong-Kun Zhang

Journal: Cell Cycle

PubMed ID: 34223793

Doi: 10.1080/15384101.2021.1918877

Products & Services: Custom DNA/RNA Oligos

The reductive carboxylation activity of heterotetrameric pyruvate synthases from hyperthermophilic archaea

Authors: Lu Xiao, Guoxia Liu, Fuyu Gong, Zhen Cai, Yin Li

Journal: Biochem Biophys Res Commun

PubMed ID: 34364295

Doi: 10.1016/j.bbrc.2021.07.091

Products & Services: Codon Optimization

Engineering a new vaccine platform for heterologous antigen delivery in live-attenuated

Authors: Esther Broset, Juan Calvet Seral, Carmen Arnal, Santiago Uranga, Alex I Kanno, Luciana C C Leite, Carlos Martín, Jesús Gonzalo-Asensio

Journal: Comput Struct Biotechnol J

PubMed ID: 34429847

Doi: 10.1016/j.csbj.2021.07.035

Products & Services: Codon Optimization

Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution

Authors: Elena G Govorunova, Oleg A Sineshchekov, Hai Li, Yumei Wang, Leonid S Brown, Alyssa Palmateer, Michael Melkonian, Shifeng Cheng, Eric Carpenter, Jordan Patterson, Gane K-S Wong, John L Spudich

Journal: MBio

PubMed ID: 34281394

Doi: 10.1128/mBio.01656-21

Products & Services: Codon Optimization

CD8 T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients

Authors: Vamsee Mallajosyula, Conner Ganjavi, Saborni Chakraborty, Alana M McSween, Ana Jimena Pavlovitch-Bedzyk, Julie Wilhelmy, Allison Nau, Monali Manohar, Kari C Nadeau, Mark M Davis

Journal: Sci Immunol

PubMed ID: 34210785

Doi: 10.1126/sciimmunol.abg5669

Products & Services: Peptide Synthesis

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

Authors: Tyler N Starr, Nadine Czudnochowski, Zhuoming Liu, Fabrizia Zatta, Young-Jun Park, Amin Addetia, Dora Pinto, Martina Beltramello, Patrick Hernandez, Allison J Greaney, Roberta Marzi, William G Glass, Ivy Zhang, Adam S Dingens, John E Bowen, M Alejandra Tortorici, Alexandra C Walls, Jason A Wojcechowskyj, Anna De Marco, Laura E Rosen, Jiayi Zhou, Martin Montiel-Ruiz, Hannah Kaiser, Josh R Dillen, Heather Tucker, Jessica Bassi, Chiara Silacci-Fregni, Michael P Housley, Julia di Iulio, Gloria Lombardo, Maria Agostini, Nicole Sprugasci, Katja Culap, Stefano Jaconi, Marcel Meury, Exequiel Dellota, Rana Abdelnabi, Shi-Yan Caroline Foo, Elisabetta Cameroni, Spencer Stumpf, Tristan I Croll, Jay C Nix, Colin Havenar-Daughton, Luca Piccoli, Fabio Benigni, Johan Neyts, Amalio Telenti, Florian A Lempp, Matteo S Pizzuto, John D Chodera, Christy M Hebner, Herbert W Virgin, Sean P J Whelan, David Veesler, Davide Corti, Jesse D Bloom, Gyorgy Snell

Journal: Nature

PubMed ID: 34261126

Doi: 10.1038/s41586-021-03807-6

Products & Services: Catalog Antibody

Advancements in structure-property correlation studies of cross-linked citric acid-based elastomers from the perspective of medical application

Authors: Filip Koper, Tomasz Swiergosz, Anna Żaba, Agata Flis, Martina Trávníčková, Lucie Bačáková, Elżbieta Pamuła, Dariusz Bogdał, Wiktor P Kasprzyk

Journal: J Mater Chem B

PubMed ID: 34323912

Doi: 10.1039/d1tb01078f

Products & Services: Custom DNA/RNA Oligos

Quantitative probing of glycosylated queuosine modifications in tRNA

Authors: Wen Zhang, Tao Pan

Journal: Methods Enzymol

PubMed ID: 34517960

Doi: 10.1016/bs.mie.2021.06.003

Products & Services: Recombinant Proteins

Development of Bacteriophage Virus-Like Particle Vaccines Displaying Conserved Epitopes of Dengue Virus Non-Structural Protein 1

Authors: Nikole L Warner, Kathryn M Frietze

Journal: Vaccines (Basel)

PubMed ID: 34358143

Doi: 10.3390/vaccines9070726

Products & Services: Peptide Synthesis

CEACAM1 Activation by CbpF-Expressing

Authors: Amjad Shhadeh, Johanna Galaski, Tamar Alon-Maimon, Jamal Fahoum, Reuven Wiener, Daniel J Slade, Ofer Mandelboim, Gilad Bachrach

Journal: Front Cell Infect Microbiol

PubMed ID: 34395310

Doi: 10.3389/fcimb.2021.699015

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Stability of SARS-CoV-2 IgG in multiple laboratory conditions and blood sample types

Authors: Jamil N Kanji, Ashley Bailey, Jayne Fenton, L Robbin Lindsay, Antonia Dibernardo, Nikki Pl Toledo, Brooks Waitt, Nadine Lecocq, Carla Osiowy, Elizabeth Giles, Jacqueline Day, William Stokes, Clayton MacDonald, LeeAnn Turnbull, Carmen Charlton

Journal: J Clin Virol

PubMed ID: 34364133

Doi: 10.1016/j.jcv.2021.104933

Products & Services: Proteins, Expression, Isolation and Analysis

Doxorubicin-Induced Fetal Mesangial Cell Death Occurs Independently of TRPC6 Channel Upregulation but Involves Mitochondrial Generation of Reactive Oxygen Species

Authors: Anberitha T Matthews, Hitesh Soni, Katherine E Robinson-Freeman, Theresa A John, Randal K Buddington, Adebowale Adebiyi

Journal: Int J Mol Sci

PubMed ID: 34299212

Doi: 10.3390/ijms22147589

Products & Services: Proteins, Expression, Isolation and Analysis

Suppression of LjBAK1-mediated immunity by SymRK promotes rhizobial infection in Lotus japonicus

Authors: Yong Feng, Ping Wu, Chao Liu, Liwei Peng, Tao Wang, Chao Wang, Qian Tan, Bixuan Li, Yajuan Ou, Hui Zhu, Songli Yuan, Renliang Huang, Gary Stacey, Zhongming Zhang, Yangrong Cao

Journal: Mol Plant

PubMed ID: 34314895

Doi: 10.1016/j.molp.2021.07.016

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma

Authors: Vid Leko, Gal Cafri, Rami Yossef, Biman Paria, Victoria Hill, Devikala Gurusamy, Zhili Zheng, Jared J Gartner, Todd D Prickett, Stephanie L Goff, Paul Robbins, Yong-Chen Lu, Steven A Rosenberg

Journal: J Immunother Cancer

PubMed ID: 34266885

Doi: 10.1136/jitc-2021-002882

Products & Services: Proteins, Expression, Isolation and Analysis

EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer

Authors: Marita Zoma, Laura Curti, Dheeraj Shinde, Domenico Albino, Abhishek Mitra, Jacopo Sgrignani, Sarah N Mapelli, Giada Sandrini, Gianluca Civenni, Jessica Merulla, Giovanna Chiorino, Paolo Kunderfranco, Alessia Cacciatore, Aleksandra Kokanovic, Andrea Rinaldi, Andrea Cavalli, Carlo V Catapano, Giuseppina M Carbone

Journal: Nat Commun

PubMed ID: 34230470

Doi: 10.1038/s41467-021-24380-6

Products & Services: Proteins, Expression, Isolation and Analysis

A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

Authors: Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hualong Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingjing Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, Minping Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yunda Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Qingbing Zheng, Shaowei Li, Yixin Chen, Tong Cheng, Jun Zhang, Tianying Zhang, Huachen Zhu, Qinjian Zhao, Quan Yuan, Yi Guan, Ningshao Xia

Journal: Sci Transl Med

PubMed ID: 34285130

Doi: 10.1126/scitranslmed.abg1143

Products & Services: Proteins, Expression, Isolation and Analysis

Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy

Authors: Divya Ravirala, Brandon Mistretta, Preethi H Gunaratne, Guangsheng Pei, Zhongming Zhao, Xiaoliu Zhang

Journal: J Immunother Cancer

PubMed ID: 34230110

Doi: 10.1136/jitc-2021-002454

Products & Services: Proteins, Expression, Isolation and Analysis

Alfalfa (Medicago sativa L) MsCML46 gene encoding calmodulin-like protein confers tolerance to abiotic stress in tobacco

Authors: Binghao Du, Naiyu Chen, Lili Song, Dan Wang, Hongsheng Cai, Lin Yao, Xiuting Li, Changhong Guo