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Peptides derived from viral glycoprotein Gc Inhibit infection of severe fever with thrombocytopenia syndrome virus

Authors: Chengfeng Gao, Yufeng Yu, Chunxia Wen, Zhifeng Li, Menghuai Sun, Shu Gao, Shuhan Lin, Shenjiao Wang, Peng Zou, Zheng Xing

Journal: Antiviral Res

PubMed ID: 34411654

Doi: 10.1016/j.antiviral.2021.105164

Products & Services: Proteins, Expression, Isolation and Analysis

Activation of Local and Systemic Defence Responses by Flg22 Is Dependent on Daytime and Ethylene in Intact Tomato Plants

Authors: Zalán Czékus, András Kukri, Kamirán Áron Hamow, Gabriella Szalai, Irma Tari, Attila Ördög, Péter Poór

Journal: Int J Mol Sci

PubMed ID: 34361121

Doi: 10.3390/ijms22158354

Products & Services: Proteins, Expression, Isolation and Analysis

Performance evaluation of three automated quantitative immunoassays and their correlation with a surrogate virus neutralization test in coronavirus disease 19 patients and pre-pandemic controls

Authors: Kiwook Jung, Sue Shin, Minjeong Nam, Yun Ji Hong, Eun Youn Roh, Kyoung Un Park, Eun Young Song

Journal: J Clin Lab Anal

PubMed ID: 34369009

Doi: 10.1002/jcla.23921

Products & Services: Proteins, Expression, Isolation and Analysis

Direct comparison of angiogenesis in natural and synthetic biomaterials reveals that matrix porosity regulates endothelial cell invasion speed and sprout diameter

Authors: William Y Wang, Robert N Kent, Stephanie A Huang, Evan H Jarman, Eve H Shikanov, Christopher D Davidson, Harrison L Hiraki, Daphne Lin, Monica A Wall, Daniel L Matera, Jae-Won Shin, William J Polacheck, Ariella Shikanov, Brendon M Baker

Journal: Acta Biomater

PubMed ID: 34469789

Doi: 10.1016/j.actbio.2021.08.038

Products & Services: Proteins, Expression, Isolation and Analysis

Photoreactive hydrogel stiffness influences volumetric muscle loss repair

Authors: Ivan M Basurto, Juliana A Passipieri, Gregg M Gardner, Kathryn K Smith, Austin R Amacher, Audrey I Hansrisuk, George J Christ, Steven R Caliari

Journal: Tissue Eng Part A

PubMed ID: 34409861

Doi: 10.1089/ten.TEA.2021.0137

Products & Services: Proteins, Expression, Isolation and Analysis

PCC-0105002, a novel small molecule inhibitor of PSD95-nNOS protein-protein interactions, attenuates neuropathic pain and corrects motor disorder associated with neuropathic pain model

Authors: Zhihong Sun, Ping Meng, Chunyu Su, Shengmin Ji, Yonglin Gao, Hongbo Wang, Jingwei Tian, Chunmei Li

Journal: Toxicol Appl Pharmacol

PubMed ID: 34428447

Doi: 10.1016/j.taap.2021.115698

Products & Services: Proteins, Expression, Isolation and Analysis

CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197-5p/CDH19 in triple-negative breast cancer

Authors: Yue Shi, Tao Han, Chong Liu

Journal: Ann Transl Med

PubMed ID: 34532373

Doi: 10.21037/atm-21-2934

Products & Services: Plasmid DNA Preparation

Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures

Authors: Erik Walinda, Daichi Morimoto, Tomoki Sorada, Kazuhiro Iwai, Kenji Sugase

Journal: Protein Expr Purif

PubMed ID: 34390872

Doi: 10.1016/j.pep.2021.105953

Products & Services: PCR Cloning and Subcloning

Tracing Clostridium perfringens strains from beef processing of slaughter house by pulsed-field gel electrophoresis, and the distribution and toxinotype of isolates in Shaanxi province, China

Authors: Yanfen Jiang, Yinghui Ma, Qianqian Liu, Tianmei Li, Yiming Li, Kangkang Guo, Yanming Zhang

Journal: Food Microbiol

PubMed ID: 34579847

Doi: 10.1016/j.fm.2021.103887

Products & Services: ORF cDNA Clones/MolecularCloud

N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2

Authors: Fang Tian, Bei Tong, Liang Sun, Shengchao Shi, Bin Zheng, Zibin Wang, Xianchi Dong, Peng Zheng

Journal: Elife

PubMed ID: 34414884

Doi: 10.7554/eLife.69091

Products & Services: Mutant Libraries

The large bat Helitron DNA transposase forms a compact monomeric assembly that buries and protects its covalently bound 5'-transposon end

Authors: Dalibor Kosek, Ivana Grabundzija, Haotian Lei, Ilija Bilic, Huaibin Wang, Yukun Jin, Graham F Peaslee, Alison B Hickman, Fred Dyda

Journal: Mol Cell

PubMed ID: 34403695

Doi: 10.1016/j.molcel.2021.07.028

Products & Services: Mutant Libraries

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3

Authors: Allison Bakovic, Nishank Bhalla, Farhang Alem, Catherine Campbell, Weidong Zhou, Aarthi Narayanan

Journal: Viruses

PubMed ID: 34452398

Doi: 10.3390/v13081533

Products & Services: Mutagenesis Services

Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett's esophagus

Authors: Nandan P Deshpande, Stephen M Riordan, Claire J Gorman, Shaun Nielsen, Tonia L Russell, Carolina Correa-Ospina, Bentotage S M Fernando, Shafagh A Waters, Natalia Castaño-Rodríguez, Si Ming Man, Nicodemus Tedla, Marc R Wilkins, Nadeem O Kaakoush

Journal: Genome Med

PubMed ID: 34412659

Doi: 10.1186/s13073-021-00951-6

Products & Services: Monoclonal Antibody Services

Dry-Cured Ham-Derived Peptide (Asp-Leu-Glu-Glu) Exerts Cytoprotective Capacity in Human Intestinal Epithelial Caco-2 Cells

Authors: Lujuan Xing, Lijuan Fu, Yuejing Hao, Wangang Zhang

Journal: Antioxidants (Basel)

PubMed ID: 34572986

Doi: 10.3390/antiox10091354

Products & Services: Molecular Biology Reagents

Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2

Authors: Jiajia Xie, Chengchao Ding, Jun He, Yuqing Zhang, Shuangshuang Ni, Xiangyu Zhang, Qingqing Chen, Jing Wang, Lina Huang, Hongliang He, Wenting Li, Huan Ma, Tengchuan Jin, Siping Zhang, Yong Gao

Journal: Front Immunol

PubMed ID: 34539645

Doi: 10.3389/fimmu.2021.715464

Products & Services: Mammalian Expression

Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity

Authors: Avery J Lam, David T S Lin, Jana K Gillies, Prakruti Uday, Anne M Pesenacker, Michael S Kobor, Megan K Levings

Journal: Cell Rep

PubMed ID: 34348163

Doi: 10.1016/j.celrep.2021.109494

Products & Services: GenParts™ DNA Fragments

Multiple G-quadruplexes in the LMNA promoter regulate LMNA variant 6 transcription and promote colon cancer cell growth

Authors: Tatsuya Nishikawa, Yuki Kuwano, Mayu Nakata, Kazuhito Rokutan, Kensei Nishida

Journal: Biochim Biophys Acta Gene Regul Mech

PubMed ID: 34419630

Doi: 10.1016/j.bbagrm.2021.194746

Products & Services: Gene Synthesis

SAMHD1 Phosphorylation at T592 Regulates Cellular Localization and S-phase Progression

Authors: Stephanie Batalis, LeAnn C Rogers, Wayne O Hemphill, Christopher H Mauney, David A Ornelles, Thomas Hollis

Journal: Front Mol Biosci

PubMed ID: 34513928

Doi: 10.3389/fmolb.2021.724870

Products & Services: DNA Sequencing

Vanillic acid and methoxyhydroquinone production from guaiacyl units and related aromatic compounds using Aspergillus niger cell factories

Authors: Ronnie J M Lubbers, Adiphol Dilokpimol, Paula A Nousiainen, Răzvan C Cioc, Jaap Visser, Pieter C A Bruijnincx, Ronald P de Vries

Journal: Microb Cell Fact

PubMed ID: 34344380

Doi: 10.1186/s12934-021-01643-x

Products & Services: DNA Sequencing

Muc5ac Production Inhibited by Decreased lncRNA H19 via PI3K/Akt/NF-kB in Asthma

Authors: Xu Chen, Jing Yang, Hailan Shen, Xuemei Zhang, Hong Wang, Guangying Wu, Yuhong Qi, Ling Wang, Wenchun Xu

Journal: J Asthma Allergy

PubMed ID: 34421304

Doi: 10.2147/JAA.S316250

Products & Services: DNA Sequencing

At sixes and sevens: cryptic domain in the metal binding chain of the human copper transporter ATP7A

Authors: Eva-Maria E Uhlemann, Woonghee Lee, Marco Tonelli, Oleg Y Dmitriev

Journal: Biophys J

PubMed ID: 34461106

Doi: 10.1016/j.bpj.2021.08.029

Products & Services: DNA Sequencing

Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease

Authors: Yunxia Xu, Ke Chen, Juanli Pan, Yingshou Lei, Danting Zhang, Lipei Fang, Jinle Tang, Xin Chen, Yanhong Ma, Yi Zheng, Bao Zhang, Yaoqi Zhou, Jian Zhan, Wei Xu

Journal: Int J Biol Macromol

PubMed ID: 34364941

Doi: 10.1016/j.ijbiomac.2021.07.184

Products & Services: DNA Sequencing

Authors: Kamila R Santos, Fernando N Souza, Eduardo M Ramos-Sanchez, Camila F Batista, Luiza C Reis, Wesley F Fotoran, Marcos B Heinemann, Hiro Goto, Magnus Gidlund, Adriano F Cunha, Angélica Rosa Faria, Hélida M Andrade, Andrey P Lage, Mônica M O P Cerqueira, Alice M M P Della Libera

Journal: Vaccines (Basel)

PubMed ID: 34452024

Doi: 10.3390/vaccines9080899

Products & Services: Custom Vector Construction

Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer

Authors: Javid Sadri Nahand, Khadijeh Khanaliha, Hamed Mirzaei, Mohsen Moghoofei, Hossein Bannazadeh Baghi, Maryam Esghaei, Ali Reza Khatami, Maryam Fatemipour, Farah Bokharaei-Salim

Journal: BMC Cancer

PubMed ID: 34399719

Doi: 10.1186/s12885-021-08658-y

Products & Services: Custom Vector Construction

Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects

Authors: Yajuan Li, Yaohua Zhang, Qingsong Hu, Sergey D Egranov, Zhen Xing, Zhao Zhang, Ke Liang, Youqiong Ye, Yinghong Pan, Sujash S Chatterjee, Brandon Mistretta, Tina K Nguyen, David H Hawke, Preethi H Gunaratne, Mien-Chie Hung, Leng Han, Liuqing Yang, Chunru Lin

Journal: Genome Med

PubMed ID: 34454586

Doi: 10.1186/s13073-021-00937-4

Products & Services: Custom Vector Construction

CRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays

Authors: Karl W Barber, Ellen Shrock, Stephen J Elledge

Journal: Mol Cell

PubMed ID: 34390675

Doi: 10.1016/j.molcel.2021.07.027

Products & Services: Custom DNA/RNA Oligos

Biochemical properties of CumA multicopper oxidase from plant pathogen, Pseudomonas syringae

Authors: Konan Ishida, Yuya Tsukamoto, Masaki Horitani, Tomohisa Ogawa, Yoshikazu Tanaka

Journal: Biosci Biotechnol Biochem

PubMed ID: 34244699

Doi: 10.1093/bbb/zbab123

Products & Services: Codon Optimization

The acute phase protein lactoferrin is a key feature of Alzheimer's disease and predictor of Aβ burden through induction of APP amyloidogenic processing

Authors: Andrew Tsatsanis, Andrew N McCorkindale, Bruce X Wong, Ellis Patrick, Tim M Ryan, Robert W Evans, Ashley I Bush, Greg T Sutherland, Asipu Sivaprasadarao, Boris Guennewig, James A Duce

Journal: Mol Psychiatry

PubMed ID: 34400772

Doi: 10.1038/s41380-021-01248-1

Products & Services: Catalog Peptides

Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR

Authors: Kyoko Furuita, Marina Hiraoka, Kentaro Hanada, Toshimichi Fujiwara, Chojiro Kojima

Journal: FEBS Lett

PubMed ID: 34312846

Doi: 10.1002/1873-3468.14166

Products & Services: Catalog Peptides

A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site

Authors: Taishi Onodera, Shunsuke Kita, Yu Adachi, Saya Moriyama, Akihiko Sato, Takao Nomura, Shuhei Sakakibara, Takeshi Inoue, Takashi Tadokoro, Yuki Anraku, Kohei Yumoto, Cong Tian, Hideo Fukuhara, Michihito Sasaki, Yasuko Orba, Nozomi Shiwa, Naoko Iwata, Noriyo Nagata, Tateki Suzuki, Jiei Sasaki, Tsuyoshi Sekizuka, Keisuke Tonouchi, Lin Sun, Shuetsu Fukushi, Hiroyuki Satofuka, Yasuhiro Kazuki, Mitsuo Oshimura, Tomohiro Kurosaki, Makoto Kuroda, Yoshiharu Matsuura, Tadaki Suzuki, Hirofumi Sawa, Takao Hashiguchi, Katsumi Maenaka, Yoshimasa Takahashi

Journal: Immunity

PubMed ID: 34508662

Doi: 10.1016/j.immuni.2021.08.025

Products & Services: Catalog Peptides

Structural insights into how Prp5 proofreads the pre-mRNA branch site

Authors: Zhenwei Zhang, Norbert Rigo, Olexandr Dybkov, Jean-Baptiste Fourmann, Cindy L Will, Vinay Kumar, Henning Urlaub, Holger Stark, Reinhard Lührmann

Journal: Nature

PubMed ID: 34349264

Doi: 10.1038/s41586-021-03789-5

Products & Services: Custom DNA/RNA Oligos

Performance comparison of micro-neutralization assays based on surrogate SARS-CoV-2 and WT SARS-CoV-2 in assessing virus-neutralizing capacity of anti-SARS-CoV-2 antibodies

Authors: Inna Sekirov, Martin Petric, Erin Carruthers, David Lawrence, Tamara Pidduck, Jesse Kustra, Jonathan Laley, Min-Kuang Lee, Navdeep Chahil, Annie Mak, Paul N Levett, Emelissa Mendoza, Heidi Wood, Mike Drebot, Mel Krajden, Muhammad Morshed

Journal: Access Microbiol

PubMed ID: 34888485

Doi: 10.1099/acmi.0.000257

Products & Services: Recombinant Proteins

Biosynthesis of silver nanoparticles with antimicrobial and anticancer properties using two novel yeasts

Authors: Xin Liu, Jia-Le Chen, Wen-Yu Yang, Yu-Cheng Qian, Jing-Yu Pan, Chen-Nianci Zhu, Li Liu, Wen-Bin Ou, Hong-Xin Zhao, Dian-Peng Zhang

Journal: Sci Rep

PubMed ID: 34349183

Doi: 10.1038/s41598-021-95262-6

Products & Services: Nucleic Acid Purification & Analysis

Ganoderic Acid A-Mediated Modulation of Microglial Polarization is Involved in Depressive-Like Behaviors and Neuroinflammation in a Rat Model of Post-Stroke Depression

Authors: Ling Zhang, Lei Zhang, Rubo Sui

Journal: Neuropsychiatr Dis Treat

PubMed ID: 34421302

Doi: 10.2147/NDT.S317207

Products & Services: Custom DNA/RNA Oligos

FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease

Authors: Robert Goold, Joseph Hamilton, Thomas Menneteau, Michael Flower, Emma L Bunting, Sarah G Aldous, Antonio Porro, José R Vicente, Nicholas D Allen, Hilary Wilkinson, Gillian P Bates, Alessandro A Sartori, Konstantinos Thalassinos, Gabriel Balmus, Sarah J Tabrizi

Journal: Cell Rep

PubMed ID: 34469738

Doi: 10.1016/j.celrep.2021.109649

Products & Services: Mutant Libraries

Single-cell imaging of T cell immunotherapy responses in vivo

Authors: Chuan Yan, Qiqi Yang, Songfa Zhang, David G Millar, Eric J Alpert, Daniel Do, Alexandra Veloso, Dalton C Brunson, Benjamin J Drapkin, Marcello Stanzione, Irene Scarfò, John C Moore, Sowmya Iyer, Qian Qin, Yun Wei, Karin M McCarthy, John F Rawls, Nick J Dyson, Mark Cobbold, Marcela V Maus, David M Langenau

Journal: J Exp Med

PubMed ID: 34415995

Doi: 10.1084/jem.20210314

Products & Services: Stable Cell Lines

Long-circulating XTEN864-annexin A5 fusion protein for phosphatidylserine-related therapeutic applications

Authors: Akvile Haeckel, Lena Ascher, Nicola Beindorff, Sonal Prasad, Karolina Garczyńska, Jing Guo, Eyk Schellenberger

Journal: Apoptosis

PubMed ID: 34405304

Doi: 10.1007/s10495-021-01686-w

Products & Services: Gene Synthesis

Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor

Authors: Yung-Hsin Huang, Chun-Wei Chen, Venkatasubramaniam Sundaramurthy, Mikolaj Slabicki, Dapeng Hao, Caroline J Watson, Ayala Tovy, Jaime M Reyes, Olga Dakhova, Brielle R Crovetti, Christina Galonska, Minjung Lee, Lorenzo Brunetti, Yubin Zhou, Katrina Tatton-Brown, Yun Huang, Xiaodong Cheng, Alexander Meissner, Peter J M Valk, Lionel Van Maldergem, Mathijs A Sanders, Jamie R Blundell, Wei Li, Benjamin L Ebert, Margaret A Goodell

Journal: Cancer Discov

PubMed ID: 34429321

Doi: 10.1158/2159-8290.CD-21-0560

Products & Services: Proteins, Expression, Isolation and Analysis

Hsp40s play complementary roles in the prevention of tau amyloid formation

Authors: Rose Irwin, Ofrah Faust, Ivana Petrovic, Sharon Grayer Wolf, Hagen Hofmann, Rina Rosenzweig

Journal: Elife

PubMed ID: 34369377

Doi: 10.7554/eLife.69601

Products & Services: Proteins, Expression, Isolation and Analysis

Single dose rVSVΔG-JUNVGP vaccine protects guinea pigs against lethal Junin virus challenge

Authors: Teresa E Sorvillo, Robert W Cross, Dylan M Johnson, Natalie S Dobias, Karla A Fenton, Chad E Mire, Thomas W Geisbert

Journal: npj Vaccines

PubMed ID: 34373461

Doi: 10.1038/s41541-021-00361-0

Products & Services: Codon Optimization

An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms

Authors: Lila Lovergne, Dhruba Ghosh, Renaud Schuck, Aris A Polyzos, Andrew D Chen, Michael C Martin, Edward S Barnard, James B Brown, Cynthia T McMurray

Journal: Sci Rep

PubMed ID: 34341363

Doi: 10.1038/s41598-021-93686-8

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Cross-neutralization of RBD mutant strains of SARS-CoV-2 by convalescent patient derived antibodies

Authors: Yan Lou, Wenxiang Zhao, Haitao Wei, Min Chu, Ruihua Chao, Hangping Yao, Junwei Su, Yanan Li, Xiulan Li, Yu Cao, Yanyan Feng, Ping Wang, Yongyang Xia, Yushuan Shang, Fengping Li, Pingju Ge, Xinglin Zhang, Wenjing Gao, Gaojie Song, Bing Du, Tingbo Liang, Yunqing Qiu, Mingyao Liu

Journal: Biotechnol J

PubMed ID: 34379353

Doi: 10.1002/biot.202100207

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

Authors: Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Sebastian Schafer, Fathima F Kuthubudeen, Anissa A Widjaja, Stuart A Cook

Journal: Elife

PubMed ID: 34435951

Doi: 10.7554/eLife.68843

Products & Services: Recombinant Proteins

Ribosylation of the CD8αβ heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10

Authors: Katharine Jennifer Goodall, Angela Nguyen, Daniel Mark Andrews, Lucy Catherine Sullivan

Journal: J Biol Chem

PubMed ID: 34478713

Doi: 10.1016/j.jbc.2021.101141

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The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy

Authors: Shayne E Quinn, Lu Huang, Jason G Kerkvliet, Joel A Swanson, Steve Smith, Adam D Hoppe, Robert B Anderson, Natalie W Thiex, Brandon L Scott

Journal: Nat Commun

PubMed ID: 34376698

Doi: 10.1038/s41467-021-25187-1

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Self-assembling synthetic nanoadjuvant scaffolds cross-link B cell receptors and represent new platform technology for therapeutic antibody production

Authors: Sujata Senapati, Ross J Darling, Kathleen A Ross, Michael J Wannemeuhler, Balaji Narasimhan, Surya K Mallapragada

Journal: Sci Adv

PubMed ID: 34348905

Doi: 10.1126/sciadv.abj1691

Products & Services: Proteins, Expression, Isolation and Analysis

Equine pituitary pars intermedia dysfunction: a spontaneous model of synucleinopathy

Authors: Jessica S Fortin, Ashley A Hetak, Kelsey E Duggan, Caroline M Burglass, Hailey B Penticoff, Harold C Schott

Journal: Sci Rep

PubMed ID: 34362943

Doi: 10.1038/s41598-021-95396-7

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Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans

Authors: Kyunghun Min, Thomas F Jannace, Haoyu Si, Krishna R Veeramah, John D Haley, James B Konopka

Journal: PLoS Pathog

PubMed ID: 34398936

Doi: 10.1371/journal.ppat.1009861

Products & Services: Polyclonal Antibody Services

Vesicular Stomatitis Virus Chimeras Expressing the Oropouche Virus Glycoproteins Elicit Protective Immune Responses in Mice

Authors: Sarah Hulsey Stubbs, Marjorie Cornejo Pontelli, Nischay Mishra, Changhong Zhou, Juliano de Paula Souza, Rosa Maria Mendes Viana, W Ian Lipkin, David M Knipe, Eurico Arruda, Sean P J Whelan

Journal: MBio

PubMed ID: 34340542

Doi: 10.1128/mBio.00463-21

Products & Services: Mammalian Expression

The Role of Hexokinase and Hexose Transporters in Preferential Use of Glucose over Fructose and Downstream Metabolic Pathways in the Yeast

Authors: Piotr Hapeta, Patrycja Szczepańska, Tadeusz Witkowski, Jean-Marc Nicaud, Anne-Marie Crutz-Le Coq, Zbigniew Lazar

Journal: Int J Mol Sci

PubMed ID: 34502217

Doi: 10.3390/ijms22179282

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