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Coleopteran-specific StaufenC functions like Loquacious-PD in dsRNA processing

Authors: Kyungbo Kim, Jinmo Koo, June-Sun Yoon, Subba Reddy Palli

Journal: RNA Biol

PubMed ID: 34376105

Doi: 10.1080/15476286.2021.1960687

Products & Services: Recombinant Antibody Expression

Nintedanib downregulates the transition of cultured systemic sclerosis fibrocytes into myofibroblasts and their pro-fibrotic activity

Authors: Maurizio Cutolo, Emanuele Gotelli, Paola Montagna, Samuele Tardito, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldano

Journal: Arthritis Res Ther

PubMed ID: 34344444

Doi: 10.1186/s13075-021-02555-2

Products & Services: Proteins, Expression, Isolation and Analysis

Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders

Authors: Florian Freudenberg, Esin Candemir, Xufeng Chen, Li-Li Li, Dilhan Esen-Sehir, Nicole Schenk, Makoto Kinoshita, Lena Grünewald, Veronika Frerichs, Nikolai Fattakhov, Jessica Manchen, Solmaz Bikas, Anita Kumar, Aet OLeary, David A Slattery, Jakob von Engelhardt, Michael J Courtney, Andreas Reif

Journal: EBioMedicine

PubMed ID: 34455393

Doi: 10.1016/j.ebiom.2021.103565

Products & Services: Proteins, Expression, Isolation and Analysis

Refining the N-Termini of the SARS-CoV-2 Spike Protein and Its Discrete Receptor-Binding Domain

Authors: Robert A D'Ippolito, Matthew R Drew, Jennifer Mehalko, Kelly Snead, Vanessa Wall, Zoe Putman, Dominic Esposito, Caroline J DeHart

Journal: J Proteome Res

PubMed ID: 34379411

Doi: 10.1021/acs.jproteome.1c00349

Products & Services: Proteins, Expression, Isolation and Analysis

Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites

Authors: Devon F Pendlebury, Jingjing Zhang, Ritvija Agrawal, Hiroki Shibuya, Jayakrishnan Nandakumar

Journal: Nat Struct Mol Biol

PubMed ID: 34373645

Doi: 10.1038/s41594-021-00635-0

Products & Services: Proteins, Expression, Isolation and Analysis

Tandem Mass Spectrometry as Strategy for the Selective Identification and Quantification of the Amyloid Precursor Protein Tyr682 Residue Phosphorylation Status in Human Blood Mononuclear Cells

Authors: Pierluigi Reveglia, Rosarita Nasso, Antonella Angiolillo, Lucia Lecce, Carmela Paolillo, Samantha De Tullio, Monica Gelzo, Alfonso Di Costanzo, Carmela Matrone, Gaetano Corso

Journal: Biomolecules

PubMed ID: 34572510

Doi: 10.3390/biom11091297

Products & Services: Peptide Synthesis

HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype

Authors: Shailesh K Shahi, Soham Ali, Camille M Jaime, Natalya V Guseva, Ashutosh K Mangalam

Journal: Immunohorizons

PubMed ID: 34380664

Doi: 10.4049/immunohorizons.2100024

Products & Services: Peptide Synthesis

CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope

Authors: Sarah A Greaves, Avinash Ravindran, Radleigh G Santos, Lan Chen, Michael T Falta, Yang Wang, Angela M Mitchell, Shaikh M Atif, Douglas G Mack, Alex N Tinega, Lisa A Maier, Shaodong Dai, Clemencia Pinilla, Johan Grunewald, Andrew P Fontenot

Journal: J Exp Med

PubMed ID: 34410304

Doi: 10.1084/jem.20210785

Products & Services: Peptide Library Services

Evolutionary and functional relationships in the ribosome biogenesis SBDS and EFL1 protein families

Authors: Alfonso Méndez-Godoy, Daniel García-Montalvo, León P Martínez-Castilla, Nuria Sánchez-Puig

Journal: Mol Genet Genomics

PubMed ID: 34453201

Doi: 10.1007/s00438-021-01814-w

Products & Services: PCR Cloning and Subcloning

New insights into the acetate uptake transporter (AceTr) family: Unveiling amino acid residues critical for specificity and activity

Authors: Toni Rendulić, João Alves, João Azevedo-Silva, Isabel Soares-Silva, Margarida Casal

Journal: Comput Struct Biotechnol J

PubMed ID: 34471488

Doi: 10.1016/j.csbj.2021.08.002

Products & Services: ORF cDNA Clones/MolecularCloud

Double-Stranded RNA-Degrading Enzymes Reduce the Efficiency of RNA Interference in

Authors: Jin-Zhi Chen, Ying-Xia Jiang, Miao-Wen Li, Jian-Wen Li, Ben-Hu Zha, Guang Yang

Journal: Insects

PubMed ID: 34442278

Doi: 10.3390/insects12080712

Products & Services: Monoclonal Antibody Services

Dynamic Changes in the Levels of Amyloid-β Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer's Disease

Authors: Liding Zhang, Changwen Yang, Yanqing Li, Shiqi Niu, Xiaohan Liang, Zhihong Zhang, Qingming Luo, Haiming Luo

Journal: Front Mol Neurosci

PubMed ID: 34512259

Doi: 10.3389/fnmol.2021.723317

Products & Services: Monoclonal Antibody Services Catalog Peptides

Compound heterozygosis in AADC deficiency: A complex phenotype dissected through comparison among heterodimeric and homodimeric AADC proteins

Authors: Carmen Longo, Riccardo Montioli, Giovanni Bisello, Luana Palazzi, Mario Mastrangelo, Heiko Brennenstuhl, Patrizia Polverino de Laureto, Thomas Opladen, Vincenzo Leuzzi, Mariarita Bertoldi

Journal: Mol Genet Metab

PubMed ID: 34479793

Doi: 10.1016/j.ymgme.2021.08.011

Products & Services: Monoclonal Antibody Services

Generation and characterization of a humanized anti-IL-17A rabbit monoclonal antibody

Authors: Wei Chen, Yong Kong, Wang Li, Yi Zhou, Meijuan Wu, Tao Chen, Yiliang Wu, Huaiyao Qiao, Zhihua Qiu, Jiwan Qiu

Journal: Protein Expr Purif

PubMed ID: 34363980

Doi: 10.1016/j.pep.2021.105950

Products & Services: Mammalian Expression

Knockdown of miR-125b-5p inhibits the proliferation and invasion of gastric carcinoma cells by targeting RYBP

Authors: Fu-E Jin, Bo Xie, Hong-Zhen Xian, Ji-Hai Wang

Journal: Kaohsiung J Med Sci

PubMed ID: 34337862

Doi: 10.1002/kjm2.12425

Products & Services: GenParts™ DNA Fragments

Structure, Antigenic Properties, and Highly Efficient Assembly of PCV4 Capsid Protein

Authors: Dongliang Wang, Jinhui Mai, Bo Lei, Yingjie Zhang, Yi Yang, Naidong Wang

Journal: Front Vet Sci

PubMed ID: 34504886

Doi: 10.3389/fvets.2021.695466

Products & Services: Gene Synthesis

Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

Authors: Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak, Paolo Ceppi

Journal: J Exp Clin Cancer Res

PubMed ID: 34364401

Doi: 10.1186/s13046-021-02049-8

Products & Services: GenCrispr Cas9 Genome Editing

Industry updates from the field of stem cell research and regenerative medicine in June 2021

Authors: Dusko Ilic, Mirjana Liovic

Journal: Regen Med

PubMed ID: 34387128

Doi: 10.2217/rme-2021-0097

Products & Services: GenCrispr Cas9 Genome Editing

P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin β1/NF-κB pathway

Authors: Limei Yan, Zeping He, Wei Li, Ning Liu, Song Gao

Journal: Cell Cycle

PubMed ID: 34382920

Doi: 10.1080/15384101.2021.1963910

Products & Services: DNA Sequencing

β-Amyloid fibrils catalyze neurotransmitter degradation

Authors: Elad Arad, Avigail Baruch Leshem, Hanna Rapaport, Raz Jelinek

Journal: Chem Catalysis

Doi: 10.1016/j.checat.2021.07.005

Products & Services: Peptide Synthesis

Identification of a peptide binding to cancer antigen Kita‐kyushu lung cancer antigen 1 from a phage‐display library

Authors: Xiaoxiao Yu, Jiayao Yan,Xiaotong Chen,Jia Wei,Lixia Yu,Fangcen Liu,Lin Li,Baorui Liu

Journal: Cancer Science

PubMed ID: 34387029

Doi: 10.1111/cas.15109

Products & Services: Antibody Services Peptide Synthesis

Sequence specific integration by the family 1 casposase from Candidatus Nitrosopumilus koreensis AR1

Authors: Xiaoke Wang, Qinling Yuan, Wenxuan Zhang, Suyu, Yang, Kejing Ren,Meiling Lu,and Yibei Xiao

Journal: Nucleic Acids Research

PubMed ID: 34428286

Doi: 10.1093/nar/gkab725

Products & Services: Gene Services

Evaluation of two Plasmodium vivax sexual stage antigens as transmission-blocking vaccine candidates

Authors: Yongzhe Zhang, Fei Liu, Yan Zhao, Fan Yang, Jie Bai, Xitong Jia, Wanlapa Roobsoong, Jetsumon Sattabongkot, Liwang Cui, Yaming Cao, Enjie Luo, Meilian Wang

Journal: Parasit Vectors

PubMed ID: 34399829

Doi: 10.1186/s13071-021-04909-w

Products & Services: Codon Optimization

Combining functional metagenomics and glycoanalytics to identify enzymes that facilitate structural characterization of sulfated N-glycans

Authors: Léa Chuzel, Samantha L Fossa, Madison L Boisvert, Samanta Cajic, René Hennig, Mehul B Ganatra, Udo Reichl, Erdmann Rapp, Christopher H Taron

Journal: Microb Cell Fact

PubMed ID: 34419057

Doi: 10.1186/s12934-021-01652-w

Products & Services: Codon Optimization

Functional Insights into Silymarin as an Antiviral Agent against Enterovirus A71 (EV-A71)

Authors: Salima Lalani, Malihe Masomian, Chit Laa Poh

Journal: Int J Mol Sci

PubMed ID: 34445463

Doi: 10.3390/ijms22168757

Products & Services: Plasmid DNA Preparation

Genome-wide characterization and expression profiling of the Phospholipase C (PLC) gene family in three orchids of economic importance

Authors: Madhvi Kanchan, Thakku R Ramkumar, Jaspreet K Sembi

Journal: J Genet Eng Biotechnol

PubMed ID: 34420115

Doi: 10.1186/s43141-021-00217-z

Products & Services: Protein Tools

PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus

Authors: Hui Li, Defang Meng, Jieting Jia, Hua Wei

Journal: Lipids Health Dis

PubMed ID: 34461924

Doi: 10.1186/s12944-021-01515-8

Products & Services: Custom DNA/RNA Oligos

Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease

Authors: Mayada Metwally, Ali Bayoumi, Anis Khan, Leon A Adams, Rocio Aller, Carmelo García-Monzón, María Teresa Arias-Loste, Elisabetta Bugianesi, Luca Miele, Alisi Anna, Olivier Latchoumanin, Shuanglin Han, Shafi Alenizi, Rasha El Sharkawy, Afaf Elattar, Rocio Gallego-Durán, Janett Fischer, Thomas Berg, Christopher Liddle, Manuel Romero-Gomez, Jacob George, Mohammed Eslam

Journal: EBioMedicine

PubMed ID: 34388518

Doi: 10.1016/j.ebiom.2021.103521

Products & Services: ORF cDNA Clones/MolecularCloud

N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization

Authors: Michael J Currie, Lavanyaa Manjunath, Christopher R Horne, Phillip M Rendle, Ramaswamy Subramanian, Rosmarie Friemann, Antony J Fairbanks, Andrew C Muscroft-Taylor, Rachel A North, Renwick C J Dobson

Journal: J Biol Chem

PubMed ID: 34437902

Doi: 10.1016/j.jbc.2021.101113

Products & Services: Plasmid DNA Preparation

Vestibular and Auditory Hair Cell Regeneration Following Targeted Ablation of Hair Cells With Diphtheria Toxin in Zebrafish

Authors: Erin Jimenez, Claire C Slevin, Luis Colón-Cruz, Shawn M Burgess

Journal: Front Cell Neurosci

PubMed ID: 34489643

Doi: 10.3389/fncel.2021.721950

Products & Services: PCR Cloning and Subcloning

Genome-Wide Identification, Expression and Functional Analysis Reveal the Involvement of FCS-Like Zinc Finger Gene Family in Submergence Response in Rice

Authors: Yamei Ma, Junliang Zhao, Hua Fu, Tifeng Yang, Jingfang Dong, Wu Yang, Luo Chen, Lian Zhou, Jian Wang, Bin Liu, Shaohong Zhang, David Edwards

Journal: Rice (N Y)

PubMed ID: 34417910

Doi: 10.1186/s12284-021-00519-3

Products & Services: Protein Tools

Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4 T-cells

Authors: Vijaya L Simhadri, Louis Hopkins, Joseph R McGill, Brian R Duke, Swati Mukherjee, Kate Zhang, Zuben E Sauna

Journal: Nat Commun

PubMed ID: 34429421

Doi: 10.1038/s41467-021-25414-9

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Impaired Cx43 gap junction endocytosis causes morphological and functional defects in zebrafish

Authors: Caitlin Hyland, Michael Mfarej, Giorgos Hiotis, Sabrina Lancaster, Noelle Novak, M Kathryn Iovine, Matthias M Falk

Journal: Mol Biol Cell

PubMed ID: 34379446

Doi: 10.1091/mbc.E20-12-0797

Influence of Fc modifications and IgG subclass on biodistribution of humanized antibodies targeting L1CAM

Authors: Sai Kiran Sharma, Maya Suzuki, Hong Xu, Joshua A Korsen, Zachary Samuels, Hongfen Guo, Brandon Nemieboka, Alessandra Piersigilli, Kimberly J Edwards, Nai-Kong Cheung, Jason S Lewis

Journal: J Nucl Med

PubMed ID: 34353869

Doi: 10.2967/jnumed.121.262383

Products & Services: Gene Synthesis

Author Correction: Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study

Authors: Anushikha Thakur, Rekha Nagpal, Avik Kumar Ghosh, Deepak Gadamshetty, Sirisha Nagapattinam, Malini Subbarao, Shreshtha Rakshit, Sneha Padiyar, Suma Sreenivas, Nagaraja Govindappa, Harish V Pai, Ramakrishnan Melarkode Subbaraman

Journal: Sci Rep

PubMed ID: 34462514

Doi: 10.1038/s41598-021-96916-1

Products & Services: Catalog Peptides

The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol

Authors: Haruka Sudo, Akira Kubo

Journal: Int J Mol Sci

PubMed ID: 34502304

Doi: 10.3390/ijms22179397

Products & Services: Mammalian Expression

Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects

Authors: Olusegun O Onabajo, Fang Wang, Mei-Hsuan Lee, Oscar Florez-Vargas, Adeola Obajemu, Chizu Tanikawa, Joselin M Vargas, Shu-Fen Liao, Ci Song, Yu-Han Huang, Chen-Yang Shen, A Rouf Banday, Thomas R O'Brien, Zhibin Hu, Koichi Matsuda, Ludmila Prokunina-Olsson

Journal: Front Immunol

PubMed ID: 34497603

Doi: 10.3389/fimmu.2021.692263

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia

Authors: Wurihan Wurihan, Yi Zou, Alec M Weber, Korri Weldon, Yehong Huang, Xiaofeng Bao, Chengsheng Zhu, Xiang Wu, Yaqun Wang, Zhao Lai, Huizhou Fan

Journal: mSystems

PubMed ID: 34342542

Doi: 10.1128/mSystems.00738-21

Products & Services: Plasmid DNA Preparation

The nucleotide addition cycle of the SARS-CoV-2 polymerase

Authors: Subhas Chandra Bera, Mona Seifert, Robert N Kirchdoerfer, Pauline van Nies, Yibulayin Wubulikasimu, Salina Quack, Flávia S Papini, Jamie J Arnold, Bruno Canard, Craig E Cameron, Martin Depken, David Dulin

Journal: Cell Rep

PubMed ID: 34433083

Doi: 10.1016/j.celrep.2021.109650

Products & Services: Codon Optimization

Spore-Trained Dendritic Cells Enhance the Generation of Memory T Cells via ICAM1

Authors: Jian Lin, Lulu Huang, Yuchen Li, Penghao Zhang, Qinghua Yu, Qian Yang

Journal: Cells

PubMed ID: 34571913

Doi: 10.3390/cells10092267

Products & Services: Catalog Peptides

Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients

Authors: Ioannis P Trougakos, Evangelos Terpos, Christina Zirou, Aimilia D Sklirou, Filia Apostolakou, Sentiljana Gumeni, Ioanna Charitaki, Eleni-Dimitra Papanagnou, Tina Bagratuni, Christine-Ivy Liacos, Andreas Scorilas, Eleni Korompoki, Ioannis Papassotiriou, Efstathios Kastritis, Meletios A Dimopoulos

Journal: BMC Med

PubMed ID: 34420521

Doi: 10.1186/s12916-021-02090-6

Rv0927c Inhibits NF-κB Pathway by Downregulating the Phosphorylation Level of IκBα and Enhances Mycobacterial Survival

Authors: Aihong Xia, Xin Li, Juanjuan Quan, Xiang Chen, Zhengzhong Xu, Xinan Jiao

Journal: Front Immunol

PubMed ID: 34531869

Doi: 10.3389/fimmu.2021.721370

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Protective humoral and cellular immune responses to SARS-CoV-2 persist up to 1 year after recovery

Authors: Chengqian Feng, Jingrong Shi, Qinghong Fan, Yaping Wang, Huang Huang, Fengjuan Chen, Guofang Tang, Youxia Li, Pingchao Li, Jiaojiao Li, Jianping Cui, Liliangzi Guo, Sisi Chen, Mengling Jiang, Liqiang Feng, Ling Chen, Chunliang Lei, Changwen Ke, Xilong Deng, Fengyu Hu, Xiaoping Tang, Feng Li

Journal: Nat Commun

PubMed ID: 34404803

Doi: 10.1038/s41467-021-25312-0

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A T-cell-based immunogenicity protocol for evaluating human antigen-specific responses

Authors: Cansu Cimen Bozkus, Ana Belen Blazquez, Tomohiro Enokida, Nina Bhardwaj

Journal: STAR Protoc

PubMed ID: 34458873

Doi: 10.1016/j.xpro.2021.100758

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Cell Stress Induces Mislocalization of Transcription Factors with Mitochondrial Enrichment

Authors: Chiara Rossi, Anna Fernàndez, Pascual Torres, Omar Ramirez-Nuñez, Ana Belén Granado-Serrano, Laia Fontdevila, Mònica Povedano, Reinald Pamplona, Isidro Ferrer, Manuel Portero-Otin

Journal: Int J Mol Sci

PubMed ID: 34445555

Doi: 10.3390/ijms22168853

Products & Services: Proteins, Expression, Isolation and Analysis

Vaccine-induced ErbB (EGFR/HER2)-specific immunity in spontaneous canine cancer

Authors: Hester A Doyle, Renelle J Gee, Tyler D Masters, Christian R Gee, Carmen J Booth, Elizabeth Peterson-Roth, Raymond A Koski, Stuart C Helfand, Lauren Price, Deborah Bascombe, Dorothy Jackson, Rita Ho, Gerald R Post, Mark J Mamula

Journal: Transl Oncol

PubMed ID: 34419682

Doi: 10.1016/j.tranon.2021.101205

Products & Services: Proteins, Expression, Isolation and Analysis

Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo

Authors: Zhaoyong Zhang, Eric Zeng, Lu Zhang, Weiming Wang, Yingkang Jin, Jiye Sun, Shuxiang Huang, Wenguang Yin, Jun Dai, Zhen Zhuang, Zhao Chen, Jing Sun, Airu Zhu, Fang Li, Weitao Cao, Xiaobo Li, Yongxia Shi, Mian Gan, Shengnan Zhang, Peilan Wei, Jicheng Huang, Nanshan Zhong, Guocai Zhong, Jingxian Zhao, Yanqun Wang, Weihui Shao, Jincun Zhao

Journal: Cell Discov

PubMed ID: 34385423

Doi: 10.1038/s41421-021-00302-0

Products & Services: Mutant Libraries

Impairment of Autophagic Flux Participates in the Antitumor Effects of TAT-Cx43 in Glioblastoma Stem Cells

Authors: Sara G Pelaz, Claudia Ollauri-Ibáñez, Concepción Lillo, Arantxa Tabernero

Journal: Cancers (Basel)

PubMed ID: 34503072

Doi: 10.3390/cancers13174262

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Genome-Wide Identification and Expression Analysis of MYB Transcription Factor Superfamily in

Authors: Tingting Zhang, Zheng Cui, Yuxin Li, Yuqian Kang, Xiqiang Song, Jian Wang, Yang Zhou

Journal: Front Genet

PubMed ID: 34512725

Doi: 10.3389/fgene.2021.714696

Products & Services: Protein Tools

SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy

Authors: Yajing Zhang, Xiaohong Yu, Qiuping Liu, Haiping Gong, An-An Chen, Hongjun Zheng, Shi Zhong, Yi Li

Journal: Mol Cancer Ther

PubMed ID: 34465596

Doi: 10.1158/1535-7163.MCT-21-0203

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