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Stabilized coronavirus spike stem elicits a broadly protective antibody

Authors: Ching-Lin Hsieh, Anne P Werner, Sarah R Leist, Laura J Stevens, Ester Falconer, Jory A Goldsmith, Chia-Wei Chou, Olubukola M Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J Fritch, Kenneth H Dinnon, Alexandra Schäfer, Mark R Denison, James D Chappell, Ralph S Baric, Barney S Graham, Kizzmekia S Corbett, Jason S McLellan

Journal: Cell Rep

PubMed ID: 34710354

Doi: 10.1016/j.celrep.2021.109929

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Sortase-mediated segmental labeling: A method for segmental assignment of intrinsically disordered regions in proteins

Authors: Kristina V Boyko, Erin A Rosenkranz, Derrick M Smith, Heather L Miears, Melissa Oueld Es Cheikh, Micah Z Lund, Jeffery C Young, Patrick N Reardon, Mark Okon, Serge L Smirnov, John M Antos

Journal: PLoS ONE

PubMed ID: 34710113

Doi: 10.1371/journal.pone.0258531

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Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces

Authors: Jazmine P Hallinan, Lindsey A Doyle, Betty W Shen, Mesfin M Gewe, Brittany Takushi, Madison A Kennedy, Della Friend, James M Roberts, Philip Bradley, Barry L Stoddard

Journal: Commun Biol

PubMed ID: 34716407

Doi: 10.1038/s42003-021-02766-y

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Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway

Authors: Caiyi Chen, Zhi Yu, Dong Lin, Xuan Wang, Xuejun Zhang, Feng Ji, Lingling He, Bin Xu

Journal: Evid Based Complement Alternat Med

PubMed ID: 34646326

Doi: 10.1155/2021/5561999

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Effect of inactivated influenza vaccination on human coronavirus infection: Secondary analysis of a randomized trial in Hutterite colonies

Authors: Andrew T Chen, Hannah D Stacey, Art Marzok, Pardeep Singh, Jann Ang, Matthew S Miller, Mark Loeb

Journal: Vaccine

PubMed ID: 34756613

Doi: 10.1016/j.vaccine.2021.10.021

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Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infection

Authors: He Ren, Chaobing Ma, Haoran Peng, Bo Zhang, Lulin Zhou, Yan Su, Xiaoyan Gao, Hongyan Huang

Journal: Biol Direct

PubMed ID: 34674770

Doi: 10.1186/s13062-021-00305-7

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Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16

Authors: Wanshun Liu, Binyu Wang, Ao Duan, Kai Shen, Qi Zhang, Xiaolu Tang, Yongzhong Wei, Jian Tang, Sheng Zhang

Journal: Cancer Cell Int

PubMed ID: 34663350

Doi: 10.1186/s12935-021-02257-4

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High mechanical property silk produced by transgenic silkworms expressing the spidroins PySp1 and ASG1

Authors: Xiaoli Tang, Xiaogang Ye, Xiaoxiao Wang, Shuo Zhao, Meiyu Wu, Jinghua Ruan, Boxiong Zhong

Journal: Sci Rep

PubMed ID: 34697320

Doi: 10.1038/s41598-021-00029-8

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Robust Neutralizing Antibody Responses 6 Months Post Vaccination with BNT162b2: A Prospective Study in 308 Healthy Individuals

Authors: Evangelos Terpos, Vangelis Karalis, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Sentiljana Gumeni, Panagiotis Malandrakis, Eleni-Dimitra Papanagnou, Efstathios Kastritis, Ioannis P Trougakos, Meletios A Dimopoulos

Journal: Life (Basel)

PubMed ID: 34685448

Doi: 10.3390/life11101077

Characterization of oleosin genes from forage sorghum in Arabidopsis and yeast reveals their role in storage lipid stability

Authors: Rabishankar Ojha, Simranjit Kaur, Kshitija Sinha, Kirti Chawla, Sumandeep Kaur, Harish Jadhav, Manmehar Kaur, Rupam Kumar Bhunia

Journal: Planta

PubMed ID: 34655341

Doi: 10.1007/s00425-021-03744-8

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Zinc Influx Restricts Enterovirus D68 Replication

Authors: Shunan Liu, Xia Cao, Haoran Guo, Wei Wei

Journal: Front Microbiol

PubMed ID: 34721351

Doi: 10.3389/fmicb.2021.748546

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Immunological Response to COVID-19 Vaccination in Ovarian Cancer Patients Receiving PARP Inhibitors

Authors: Michalis Liontos, Evangelos Terpos, Christos Markellos, Flora Zagouri, Alexandros Briasoulis, Ioanna Katsiana, Efthymia Skafida, Oraianthi Fiste, Elena Kunadis, Angeliki Andrikopoulou, Maria Kaparelou, Konstantinos Koutsoukos, Maria Gavriatopoulou, Efstathios Kastritis, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Vaccines (Basel)

PubMed ID: 34696256

Doi: 10.3390/vaccines9101148

Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo

Authors: Yuan Fang , Zezhong Liu , Yang Qiu , Jing Kong, Yuhong Fu, Yujie Liu , Chong Wang , Jia Quan , Qian Wang , Wei Xu , Lei Yin , Jie Cui , Yi Xu , Stephen Curry , Shibo Jiang , Lu Lu , Xi Zhou

Journal: Immunity

PubMed ID: 34555337

Doi: 10.1016/j.immuni.2021.08.027

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Microscopic Screening of Cyclodextrin Channel Blockers by DiffusiOptoPhysiology

Authors: Xiaoyu Du, Yuqin Wang, Shanyu Zhang, Pingping Fan, Shuanghong Yan, Panke Zhang, Hong-Yuan Chen, Shuo Huang

Journal: Anal Chem

PubMed ID: 34641671

Doi: 10.1021/acs.analchem.1c02775

Products & Services: Plasmid DNA Preparation

Rapid and Sensitive Diagnosis of Drug-Resistant FLT3-F691L Mutation by CRISPR Detection

Authors: Yin Liu, Yanling Chen, Shisheng Huang, Xiaodong Ma, Xingxu Huang, Xinjie Wang, Fuling Zhou

Journal: Frontiers

Doi: 10.3389/fmolb.2021.753276

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Surrogate test performance for SARS-CoV-2 neutralizing antibodies (nAbs) for convalescent plasma (CCP): How useful could they be?

Authors: Silvano Wendel, Roberta Fachini, Rita C L Fontão-Wendel, Ralyria Mello, Carlos Vinícius Velasquez, Rafael Rahal Guaragna Machado, Mayra Altobelli Brito, Marcelo Amaral, Camila Pereira Soares, Ruth Achkar, Patrícia Scuracchio, Sandra Cristina Miyaji, Melina Santos Erdens, Edison Luiz Durigon

Journal: Transfusion

PubMed ID: 34674284

Doi: 10.1111/trf.16714

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Kinetics of immune responses to the AZD1222/Covishield vaccine with varying dose intervals in Sri Lankan individuals

Authors: Chandima Jeewandara, Inoka Sepali Aberathna, Laksiri Gomes, Pradeep Darshana Pushpakumara, Saubhagya Danasekara, Dinuka Guruge, Thushali Ranasinghe, Banuri Gunasekera, Achala Kamaladasa, Heshan Kuruppu, Gayasha Somathilake, Osanda Dissanayake, Nayanathara Gamalath, Dinithi Ekanayake, Jeewantha Jayamali, Deshni Jayathilaka, Anushika Mudunkotuwa, Michael Harvie, Thashmi Nimasha, Ruwan Wijayamuni, Lisa Schimanski, Pramila Rijal, Tiong K Tan, Tao Dong, Alain Townsend, Graham S Ogg, Gathsaurie Neelika Malavige

Journal: medrxiv

PubMed ID: 34729569

Doi: 10.1101/2021.10.27.21265561

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Comparing Five SARS-CoV-2 Antibody Assay Results Before and After the First and Second ChAdOx1 nCoV-19 Vaccination Among Health Care Workers: A Prospective Multicenter Study

Authors: Seri Jeong, Nuri Lee, Su Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun Ju Jung, Heungjeong Woo, Yu Bin Seo, Jin Ju Park, Hyun Soo Kim

Journal: J Clin Microbiol

PubMed ID: 34613799

Doi: 10.1128/JCM.01788-21

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Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

Authors: Hyeseon Cho, Kristina Kay Gonzales-Wartz, Deli Huang, Meng Yuan, Mary Peterson, Janie Liang, Nathan Beutler, Jonathan L Torres, Yu Cong, Elena Postnikova, Sandhya Bangaru, Chloe Adrienna Talana, Wei Shi, Eun Sung Yang, Yi Zhang, Kwanyee Leung, Lingshu Wang, Linghang Peng, Jeff Skinner, Shanping Li, Nicholas C Wu, Hejun Liu, Cherrelle Dacon, Thomas Moyer, Melanie Cohen, Ming Zhao, Frances Eun-Hyung Lee, Rona S Weinberg, Iyadh Douagi, Robin Gross, Connie Schmaljohn, Amarendra Pegu, John R Mascola, Michael Holbrook, David Nemazee, Thomas F Rogers, Andrew B Ward, Ian A Wilson, Peter D Crompton, Joshua Tan

Journal: Sci Transl Med

PubMed ID: 34519517

Doi: 10.1126/scitranslmed.abj5413

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SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α

Authors: Maoquan Li, Jinqiu Ning, Jiwei Wang, Qiqian Yan, Ke Zhao, Xiaoshi Jia

Journal: Int J Mol Med

PubMed ID: 34617577

Doi: 10.3892/ijmm.2021.5043

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Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter

Authors: Dolores Piniella, Elena Martínez-Blanco, David Bartolomé-Martín, Ana B Sanz-Martos, Francisco Zafra

Journal: Cell Mol Life Sci

PubMed ID: 34709416

Doi: 10.1007/s00018-021-03998-1

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Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

Authors: Guha Asthagiri Arunkumar, Disha Bhavsar, Tiehai Li, Shirin Strohmeier, Veronika Chromikova, Fatima Amanat, Mehman Bunyatov, Patrick C Wilson, Ali H Ellebedy, Geert-Jan Boons, Viviana Simon, Robert P de Vries, Florian Krammer

Journal: Nat Commun

PubMed ID: 34697321

Doi: 10.1038/s41467-021-26409-2

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Tetramethylpyrazine Alleviates Tight Junction Disruption of Bronchial Mucosal Epithelial Cells Caused by Interleukin-17 via Inhibiting Nuclear Factor-κB-p65/Tumor Necrosis Factor-α Signaling Pathway

Authors: Xin Lin, Yong Zhu, Guohui Le

Journal: J Interferon Cytokine Res

PubMed ID: 34698528

Doi: 10.1089/jir.2021.0083

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Characterization of From the Marine Crab and Its Functions Under Low Salinity Conditions

Authors: Xianyun Ren, Lei Wang, Yao Xu, Qiong Wang, Jianjian Lv, Ping Liu, Jian Li

Journal: Front Physiol

PubMed ID: 34744765

Doi: 10.3389/fphys.2021.724693

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Metabolic Engineering of for Improved 2,3-Butanediol Production by Manipulating NADH Levels and Overexpressing the Small RNA RyhB

Authors: Yan Wu, Wanying Chu, Jiayao Yang, Yudong Xu, Qi Shen, Haoning Yang, Fangxu Xu, Yefei Liu, Ping Lu, Ke Jiang, Hongxin Zhao

Journal: Front Microbiol

PubMed ID: 34691005

Doi: 10.3389/fmicb.2021.754306

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The envelope protein of Usutu virus attenuates West Nile virus virulence in immunocompetent mice

Authors: Guendalina Zaccaria, Daniela Malatesta, Lucija Jurisic, Maurilia Marcacci, Giovanni Di Teodoro, Annamaria Conte, Liana Teodori, Federica Monaco, Valeria Marini, Claudia Casaccia, Giovanni Savini, Annapia Di Gennaro, Emanuela Rossi, Vincenzo D'Innocenzo, Nicola D'Alterio, Alessio Lorusso

Journal: Vet Microbiol

PubMed ID: 34715462

Doi: 10.1016/j.vetmic.2021.109262

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Novel Phage-Derived Depolymerase with Activity against Biofilms

Authors: Cormac J Rice, Stephen A Kelly, Seamus C O'Brien, Erinn M Melaugh, Jan C B Ganacias, Zheng Hua Chai, Brendan F Gilmore, Timofey Skvortsov

Journal: Microorganisms

PubMed ID: 34683494

Doi: 10.3390/microorganisms9102172

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Regulate the hydrophobic motif to enhance the non-classical secretory expression of Pullulanase PulA in Bacillus subtilis

Authors: Jie Zhen, Hongchen Zheng, Xingya Zhao, Xiaoping Fu, Shibin Yang, Jianyong Xu, Hui Song, Yanhe Ma

Journal: Int J Biol Macromol

PubMed ID: 34710472

Doi: 10.1016/j.ijbiomac.2021.10.164

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Mutant in Aldosterone-Producing Adenoma Leads to Cell Proliferation

Authors: Kazuhiro Kobuke, Kenji Oki, Celso E Gomez-Sanchez, Elise P Gomez-Sanchez, Kiyotaka Itcho, Haruya Ohno, Gaku Nagano, Yoko Yoshii, Ryuta Baba, Takaya Kodama, Koji Arihiro, Noboru Hattori, Masayasu Yoneda

Journal: Int J Mol Sci

PubMed ID: 34681640

Doi: 10.3390/ijms222010981

Products & Services: PCR Cloning and Subcloning

Neuroligin 3 from common cutworm enhances the GABA-induced current of recombinant SlRDL1 channel

Authors: Ying Wang, Yi-Chi Zhang, Ke-Xin Zhang, Zhong-Qiang Jia, Tao Tang, Lin-Lin Zheng, Di Liu, Chun-Qing Zhao

Journal: Pest Manag Sci

PubMed ID: 34619015

Doi: 10.1002/ps.6669

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FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2

Authors: Jenna M DeLuca, Maegan K Murphy, Xin Wang, Timothy J Wilson

Journal: J Immunol

PubMed ID: 34697226

Doi: 10.4049/jimmunol.2100218

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Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

Authors: Vincent Dussupt, Rajeshwer S Sankhala, Letzibeth Mendez-Rivera, Samantha M Townsley, Fabian Schmidt, Lindsay Wieczorek, Kerri G Lal, Gina C Donofrio, Ursula Tran, Nathaniel D Jackson, Weam I Zaky, Michelle Zemil, Sarah R Tritsch, Wei-Hung Chen, Elizabeth J Martinez, Aslaa Ahmed, Misook Choe, William C Chang, Agnes Hajduczki, Ningbo Jian, Caroline E Peterson, Phyllis A Rees, Magdalena Rutkowska, Bonnie M Slike, Christopher N Selverian, Isabella Swafford, I-Ting Teng, Paul V Thomas, Tongqing Zhou, Clayton J Smith, Jeffrey R Currier, Peter D Kwong, Morgane Rolland, Edgar Davidson, Benjamin J Doranz, Christopher N Mores, Theodora Hatziioannou, William W Reiley, Paul D Bieniasz, Dominic Paquin-Proulx, Gregory D Gromowski, Victoria R Polonis, Nelson L Michael, Kayvon Modjarrad, M Gordon Joyce, Shelly J Krebs

Journal: Nat Immunol

PubMed ID: 34716452

Doi: 10.1038/s41590-021-01068-z

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Identification and characterization of arginine kinase, a novel allergen that causes cross-reactivity among shellfish

Authors: Fei Huan, Tian-Jiao Han, Meng Liu, Meng-Si Li, Yang Yang, Qing-Mei Liu, Dong Lai, Min-Jie Cao, Guang-Ming Liu

Journal: Food Funct

PubMed ID: 34664604

Doi: 10.1039/d1fo02042k

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The selective degradation of sirtuins via macroautophagy in the MPP model of Parkinson's disease is promoted by conserved oxidation sites

Authors: Marius W Baeken, Mario Schwarz, Andreas Kern, Bernd Moosmann, Parvana Hajieva, Christian Behl

Journal: Cell Death Discov

PubMed ID: 34642296

Doi: 10.1038/s41420-021-00683-x

Products & Services: Mammalian Expression

Poor protective potential of influenza nucleoprotein antibodies despite wide prevalence

Authors: Hillary A Vanderven, Robyn Esterbauer, Sinthujan Jegaskanda, Hyon-Xhi Tan, Adam K Wheatley, Stephen J Kent

Journal: Immunol Cell Biol

PubMed ID: 34687553

Doi: 10.1111/imcb.12508

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Ultrasensitive Detection of SARS-CoV-2 Spike Proteins Using the Thio-NAD Cycling Reaction: A Preliminary Study before Clinical Trials

Authors: Yuta Kyosei, Mayuri Namba, Daiki Makioka, Ayumi Kokubun, Satoshi Watabe, Teruki Yoshimura, Tadahiro Sasaki, Tatsuo Shioda, Etsuro Ito

Journal: Microorganisms

PubMed ID: 34835340

Doi: 10.3390/microorganisms9112214

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Nucleolin Aptamer N6L Reprograms the Translational Machinery and Acts Synergistically with mTORi to Inhibit Pancreatic Cancer Proliferation

Authors: Mounira Chalabi-Dchar, Elisabeth Cruz, Hichem C Mertani, Jean-Jacques Diaz, José Courty, Ilaria Cascone, Philippe Bouvet

Journal: Cancers (Basel)

PubMed ID: 34638443

Doi: 10.3390/cancers13194957

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Overexpression of a carrot BCH gene, DcBCH1, improves tolerance to drought in Arabidopsis thaliana

Authors: Tong Li, Jie-Xia Liu, Yuan-Jie Deng, Zhi-Sheng Xu, Ai-Sheng Xiong

Journal: BMC Plant Biol

PubMed ID: 34663216

Doi: 10.1186/s12870-021-03236-7

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Structural and allergenic properties of the Fatty Acid Binding Protein from shrimp Litopenaeus vannamei

Authors: Marlon Múnera, Dalgys Martínez, Judith Wortmann, Josefina Zakzuk, Walter Keller, Luis Caraballo, Leonardo Puerta

Journal: Allergy

PubMed ID: 34695231

Doi: 10.1111/all.15154

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Efficient Multi-Sites Genome Editing and Plant Regeneration Somatic Embryogenesis in

Authors: Ying Cui, Jian Zhao, Ying Gao, Ruirui Zhao, Jinfeng Zhang, Lisheng Kong

Journal: Front Plant Sci

PubMed ID: 34721480

Doi: 10.3389/fpls.2021.751891

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PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway

Authors: Gang Zhao, Xiaobao Shi, Zhanbo Sun, Pengfei Zhao, Zaiming Lu

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 34718369

Doi: 10.1093/abbs/gmab143

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Cardiovascular Progerin Suppression and lamin A Restoration Rescues Hutchinson-Gilford Progeria Syndrome

Authors: Amanda Sánchez-López, Carla Espinós-Estévez, Cristina González-Gómez, Pilar Gonzalo, María J Andrés-Manzano, Víctor Fanjul, Raquel Riquelme-Borja, Magda R Hamczyk, Álvaro Macías, Lara Del Campo, Emilio Camafeita, Jesús Vázquez, Anna Barkaway, Loïc Rolas, Sussan Nourshargh, Beatriz Dorado, Ignacio Benedicto, Vicente Andrés

Journal: Circulation

PubMed ID: 34694158

Doi: 10.1161/CIRCULATIONAHA.121.055313

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The ubiquitous buried water in the beta-trefoil architecture contributes to the folding nucleus and ~20% of the folding enthalpy

Authors: Joseph B Parker, Connie A Tenorio, Michael Blaber

Journal: Protein Sci

PubMed ID: 34562298

Doi: 10.1002/pro.4192

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Advancements in the Growth and Construction of Recombinant Lumpy Skin Disease Virus (LSDV) for Use as a Vaccine Vector

Authors: Michiel van Diepen, Rosamund Chapman, Nicola Douglass, Leah Whittle, Nicole Chineka, Shireen Galant, Christian Cotchobos, Akiko Suzuki, Anna-Lise Williamson

Journal: Vaccines (Basel)

PubMed ID: 34696239

Doi: 10.3390/vaccines9101131

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A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide

Authors: Kellan T Passow, Haley S Caldwell, Kiet A Ngo, Jamie J Arnold, Nicole M Antczak, Anoop Narayanan, Joyce Jose, Shana J Sturla, Craig E Cameron, Alexander T Ciota, Daniel A Harki

Journal: J Med Chem

PubMed ID: 34661397

Doi: 10.1021/acs.jmedchem.1c01481

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Mutational analysis of TlyA from Brachyspira hampsonii reveals two key residues conserved in pathogenic bacteria responsible for oligomerization and hemolytic activity

Authors: Brandon A Keith, John C S Harding, Matthew E Loewen

Journal: Biochim Biophys Acta Gen Subj

PubMed ID: 34715264

Doi: 10.1016/j.bbagen.2021.130045

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Repeating Aspartic Acid Residues Prefer Turn-like Conformations in the Unfolded State: Implications for Early Protein Folding

Authors: Bridget Milorey, Harald Schwalbe, Nichole O'Neill, Reinhard Schweitzer-Stenner

Journal: J Phys Chem B

PubMed ID: 34619031

Doi: 10.1021/acs.jpcb.1c06472

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Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2-infected individuals reveal unlinked immune signatures

Authors: Supriya Ravichandran, Gabrielle Grubbs, Juanjie Tang, Youri Lee, Chang Huang, Hana Golding, Surender Khurana

Journal: Sci Adv

PubMed ID: 34644111

Doi: 10.1126/sciadv.abi6533

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Synthetic virology: the experts speak

Authors:

Journal: Nat Biotechnol

PubMed ID: 34599304

Doi: 10.1038/s41587-021-01078-0

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Generation of recombinant vaccinia virus and analysis of virus-induced cell death

Authors: Zhijun Liu, Kidong Kang, Francis Ka-Ming Chan

Journal: STAR Protoc

PubMed ID: 34661172

Doi: 10.1016/j.xpro.2021.100871

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