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页码: 184/1028 每页显示数量

NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms

Authors: Zikai Zhou, Guiqin He, Xiaoyun Zhang, Xin Lv, Xiaolin Zhang, An Liu, Shuting Xia, Hao Xie, Rui Dang, Lifang Han, Junxia Qi, Yanghong Meng, Shunying Yu, Wei Xie, Zhengping Jia

Journal: Cell Rep

PubMed ID: 34407403

Doi: 10.1016/j.celrep.2021.109515

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Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress

Authors: Lauren E Williamson, Kristen M Reeder, Kevin Bailey, Minh H Tran, Vicky Roy, Mallorie E Fouch, Nurgun Kose, Andrew Trivette, Rachel S Nargi, Emma S Winkler, Arthur S Kim, Christopher Gainza, Jessica Rodriguez, Erica Armstrong, Rachel E Sutton, Joseph Reidy, Robert H Carnahan, W Hayes McDonald, Clara T Schoeder, William B Klimstra, Edgar Davidson, Benjamin J Doranz, Galit Alter, Jens Meiler, Kevin L Schey, Justin G Julander, Michael S Diamond, James E Crowe

Journal: Cell

PubMed ID: 34416147

Doi: 10.1016/j.cell.2021.07.033

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Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium yoelii liver stage

Authors: Kamalakannan Vijayan, Ganesh Ram R Visweswaran, Ramyavardhanee Chandrasekaran, Olesya Trakhimets, Samantha L Brown, Alexander Watson, Meghan Zuck, Nicholas Dambrauskas, Andrew Raappana, Sara Carbonetti, Laurel Kelnhofer-Millevolte, Elizabeth K K Glennon, Rachel Postiglione, D Noah Sather, Alexis Kaushansky

Journal: Cell Rep

PubMed ID: 34348141

Doi: 10.1016/j.celrep.2021.109489

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A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity

Authors: Krishna Das, Elodie Belnoue, Matteo Rossi, Tamara Hofer, Sarah Danklmaier, Tobias Nolden, Liesa-Marie Schreiber, Katharina Angerer, Janine Kimpel, Sandra Hoegler, Bart Spiesschaert, Lukas Kenner, Dorothee von Laer, Knut Elbers, Madiha Derouazi, Guido Wollmann

Journal: Nat Commun

PubMed ID: 34465781

Doi: 10.1038/s41467-021-25506-6

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Structural basis for Ca activation of the heteromeric PKD1L3/PKD2L1 channel

Authors: Qiang Su, Mengying Chen, Yan Wang, Bin Li, Dan Jing, Xiechao Zhan, Yong Yu, Yigong Shi

Journal: Nat Commun

PubMed ID: 34381056

Doi: 10.1038/s41467-021-25216-z

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Systematic Genome-Wide Study and Expression Analysis of Gene Family: Sugar Transporter Family Contributes to Biotic and Abiotic Stimuli in Watermelon

Authors: Changqing Xuan, Guangpu Lan, Fengfei Si, Zhilong Zeng, Chunxia Wang, Vivek Yadav, Chunhua Wei, Xian Zhang

Journal: Int J Mol Sci

PubMed ID: 34445115

Doi: 10.3390/ijms22168407

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Extremely short bioavailability and fast pharmacodynamic effects of pMHC-based nanomedicines

Authors: Yang Yang, Kristofor K Ellestad, Santiswarup Singha, Muhammad Myn Uddin, Robert Clarke, Debajyoti Mondal, Nahir Garabatos, Patricia Solé, Cesar Fandos, Pau Serra, Pere Santamaria

Journal: J Control Release

PubMed ID: 34474072

Doi: 10.1016/j.jconrel.2021.08.043

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An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism

Authors: Jerod L Ptacin, Carolina E Caffaro, Lina Ma, Kristine M San Jose Gall, Hans R Aerni, Nicole V Acuff, Rob W Herman, Yelena Pavlova, Michael J Pena, David B Chen, Lilia K Koriazova, Laura K Shawver, Ingrid B Joseph, Marcos E Milla

Journal: Nat Commun

PubMed ID: 34373459

Doi: 10.1038/s41467-021-24987-9

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A resource of high-quality and versatile nanobodies for drug delivery

Authors: Zhuolun Shen, Yufei Xiang, Sandra Vergara, Apeng Chen, Zhengyun Xiao, Ulises Santiago, Changzhong Jin, Zhe Sang, Jiadi Luo, Kong Chen, Dina Schneidman-Duhovny, Carlos Camacho, Guillermo Calero, Baoli Hu, Yi Shi

Journal: iScience

PubMed ID: 34522857

Doi: 10.1016/j.isci.2021.103014

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Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

Authors: Juanjie Tang, Youri Lee, Supriya Ravichandran, Gabrielle Grubbs, Chang Huang, Charles B Stauft, Tony Wang, Basil Golding, Hana Golding, Surender Khurana

Journal: iScience

PubMed ID: 34430803

Doi: 10.1016/j.isci.2021.103006

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Functional Characterization of the Nemertide α Family of Peptide Toxins

Authors: Erik Jacobsson, Steve Peigneur, Håkan S Andersson, Quentin Laborde, Malin Strand, Jan Tytgat, Ulf Göransson

Journal: J Nat Prod

PubMed ID: 34445875

Doi: 10.1021/acs.jnatprod.1c00104

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Fast and efficient generation of a full-length balancer chromosome by a single Cre/loxP recombination event

Authors: Cunxiang Ju, Mingkun Zhang, Min Guan, Song Li, Yuxi Zhang, Jing Zhao, Xiang Gao

Journal: Mamm Genome

PubMed ID: 34386878

Doi: 10.1007/s00335-021-09897-x

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Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

Authors: Catarina F Almeida, Dylan G M Smith, Tan-Yun Cheng, Chris M Harpur, Elena Batleska, Catriona V Nguyen-Robertson, Tram Nguyen, Tamara Thelemann, Scott J J Reddiex, Shihan Li, Sidonia B G Eckle, Ildiko Van Rhijn, Jamie Rossjohn, Adam P Uldrich, D Branch Moody, Spencer J Williams, Daniel G Pellicci, Dale I Godfrey

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34417291

Doi: 10.1073/pnas.2104420118

Products & Services: Plasmid DNA Preparation

SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

Authors: Jiří Zahradník, Shir Marciano, Maya Shemesh, Eyal Zoler, Daniel Harari, Jeanne Chiaravalli, Björn Meyer, Yinon Rudich, Chunlin Li, Ira Marton, Orly Dym, Nadav Elad, Mark G Lewis, Hanne Andersen, Matthew Gagne, Robert A Seder, Daniel C Douek, Gideon Schreiber

Journal: Nat Microbiol

PubMed ID: 34400835

Doi: 10.1038/s41564-021-00954-4

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Molecular mechanisms of centipede toxin SsTx-4 inhibition of inwardly rectifying potassium channels

Authors: Dongfang Tang, Jiahui Xu, Yinping Li, Piao Zhao, Xiangjin Kong, Haoliang Hu, Songping Liang, Cheng Tang, Zhonghua Liu

Journal: J Biol Chem

PubMed ID: 34391777

Doi: 10.1016/j.jbc.2021.101076

Products & Services: Recombinant Antibody Expression

Influence of Electrolyte Concentration on Single-Molecule Sensing of Perfluorocarboxylic Acids

Authors: Xinyun Yao, Ning-Ning Song, Jia Wang, Xian Zhao, Meng-Yuan Cheng, Jiaqi Zuo, Kaipei Qiu

Journal: Front Chem

PubMed ID: 34414165

Doi: 10.3389/fchem.2021.732378

Products & Services: Proteins, Expression, Isolation and Analysis

Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice

Authors: Mingyuan Han, Tomoko Ishikawa, Claudia C Stroupe, Haley A Breckenridge, J Kelley Bentley, Marc B Hershenson

Journal: Mucosal Immunol

PubMed ID: 34354243

Doi: 10.1038/s41385-021-00436-0

Products & Services: Mammalian Expression

Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions

Authors: Michael C Yoon, Angelo Solania, Zhenze Jiang, Mitchell P Christy, Sonia Podvin, Charles Mosier, Christopher B Lietz, Gen Ito, William H Gerwick, Dennis W Wolan, Gregory Hook, Anthony J O'Donoghue, Vivian Hook

Journal: ACS Chem Biol

PubMed ID: 34416110

Doi: 10.1021/acschembio.1c00138

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Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway

Authors: Feifei Huang, Tianyun Gao, Wenqing Wang, Liudi Wang, Yuanyuan Xie, Chenxun Tai, Shuo Liu, Yi Cui, Bin Wang

Journal: Stem Cell Res Ther

PubMed ID: 34419172

Doi: 10.1186/s13287-021-02537-w

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Proteome-Wide Profiling of Readers for DNA Modification

Authors: Lin Bai, Guojian Yang, Zhaoyu Qin, Jiacheng Lyu, Yunzhi Wang, Jinwen Feng, Mingwei Liu, Tongqing Gong, Xianju Li, Zhengyang Li, Jixi Li, Jun Qin, Wenjun Yang, Chen Ding

Journal: Adv Sci (Weinh)

PubMed ID: 34351703

Doi: 10.1002/advs.202101426

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Genome-Wide Characterization and Expression Analysis Provide Basis to the Biological Function of Cotton FBA Genes

Authors: Zhong-Qing Li, Yao Zhang, He Li, Ting-Ting Su, Cheng-Gong Liu, Zi-Chao Han, Ai-Ying Wang, Jian-Bo Zhu

Journal: Front Plant Sci

PubMed ID: 34490001

Doi: 10.3389/fpls.2021.696698

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Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene

Authors: Melanie L Bailey, David Tieu, Andrea Habsid, Amy Hin Yan Tong, Katherine Chan, Jason Moffat, Philip Hieter

Journal: Life Sci Alliance

PubMed ID: 34462321

Doi: 10.26508/lsa.202101083

Products & Services: DNA Sequencing

Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

Authors: Fei Liu, Amy C H Lee, Fang Guo, Andrew S Kondratowicz, Holly M Micolochick Steuer, Angela Miller, Lauren D Bailey, Xiaohe Wang, Shuai Chen, Steven G Kultgen, Andrea Cuconati, Andrew G Cole, Dimitar Gotchev, Bruce D Dorsey, Rene Rijnbrand, Angela M Lam, Michael J Sofia, Min Gao

Journal: J Virol

PubMed ID: 34191584

Doi: 10.1128/JVI.00574-21

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Design of Broadly Cross-Reactive M Protein-Based Group A Streptococcal Vaccines

Authors: Michelle P Aranha, Thomas A Penfound, Sanaz Salehi, Anne Botteaux, Pierre Smeesters, James B Dale, Jeremy C Smith

Journal: J Immunol

PubMed ID: 34341168

Doi: 10.4049/jimmunol.2100286

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-Specific T Cell Functional, Memory, and Activation Profiles in QuantiFERON-Reverters Are Consistent With Controlled Infection

Authors: Cheleka A M Mpande, Pia Steigler, Tessa Lloyd, Virginie Rozot, Boitumelo Mosito, Constance Schreuder, Timothy D Reid, Nicole Bilek, Morten Ruhwald, Jason R Andrews, Mark Hatherill, Francesca Little, Thomas J Scriba, Elisa Nemes

Journal: Front Immunol

PubMed ID: 34526988

Doi: 10.3389/fimmu.2021.712480

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Longitudinal Follow-up of Antibody Responses in Pediatric Patients With COVID-19 up to 9 Months After Infection

Authors: Pembe Derin Oygar, Yasemin Ozsurekci, Sibel Lacinel Gurlevik, Kubra Aykac, Musa Gurel Kukul, Burcu Ceylan Cura Yayla, Sare Ilbay, Jale Karakaya, Ozlem Teksam, Ali Bulent Cengiz, Mehmet Ceyhan

Journal: Pediatr Infect Dis J

PubMed ID: 34250968

Doi: 10.1097/INF.0000000000003199

Products & Services: Proteins, Expression, Isolation and Analysis

Synthesis of precision antibody conjugates using proximity-induced chemistry

Authors: Yu J Cao, Chenfei Yu, Kuan-Lin Wu, Xuechun Wang, Dong Liu, Zeru Tian, Lijun Zhao, Xuexiu Qi, Axel Loredo, Anna Chung, Han Xiao

Journal: Theranostics

PubMed ID: 34522229

Doi: 10.7150/thno.62444

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Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation

Authors: Caixia Liu, Benlong Cai, Dan Li, Yuan Yao

Journal: Innate Immun

PubMed ID: 34428935

Doi: 10.1177/17534259211035426

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Influence of in vitro neuronal membranes on the anti-amyloidogenic activity of gallic acid: Implication for the therapy of Alzheimer's disease

Authors: Stéphanie Andrade, Joana Angélica Loureiro, Maria do Carmo Pereira

Journal: Arch Biochem Biophys

PubMed ID: 34461085

Doi: 10.1016/j.abb.2021.109022

Products & Services: Mammalian Expression

Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru

Authors: Luis M Jara, Cusi Ferradas, Francesca Schiaffino, Camila Sánchez-Carrión, Ana Martínez-Vela, Alexandra Ulloa, Gisela Isasi-Rivas, Angela Montalván, Luis Guevara Sarmiento, Manolo Fernández, Mirko Zimic

Journal: One Health

PubMed ID: 34462726

Doi: 10.1016/j.onehlt.2021.100318

Products & Services: Proteins, Expression, Isolation and Analysis

Activation of gene expression by detergent-like protein domains

Authors: Bradley K Broyles, Andrew T Gutierrez, Theodore P Maris, Daniel A Coil, Thomas M Wagner, Xiao Wang, Daisuke Kihara, Caleb A Class, Alexandre M Erkine

Journal: iScience

PubMed ID: 34522860

Doi: 10.1016/j.isci.2021.103017

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A novel pine wood nematode effector, BxSCD1, suppresses plant immunity and interacts with an ethylene-forming enzyme in pine

Authors: Tong-Yue Wen, Xiao-Qin Wu, Long-Jiao Hu, Yi-Jun Qiu, Lin Rui, Yan Zhang, Xiao-Lei Ding, Jian-Ren Ye

Journal: Mol Plant Pathol

PubMed ID: 34396673

Doi: 10.1111/mpp.13121

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia

Authors: Jan-Erik Messling, Karl Agger, Kasper L Andersen, Kristina Kromer, Hanna Maria Kuepper, Anders H Lund, Kristian Helin

Journal: Blood

PubMed ID: 34359076

Doi: 10.1182/blood.2021012629

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How to Sequence Therapies in Waldenström Macroglobulinemia

Authors: Shayna Sarosiek, Steven P Treon, Jorge J Castillo

Journal: Curr Treat Options Oncol

PubMed ID: 34426943

Doi: 10.1007/s11864-021-00890-9

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Glucagon-like peptide-1 receptor controls exocytosis in chromaffin cells by increasing full-fusion events

Authors: Ayoze González-Santana, Judith Estévez-Herrera, Elizabeth P Seward, Ricardo Borges, José David Machado

Journal: Cell Rep

PubMed ID: 34433018

Doi: 10.1016/j.celrep.2021.109609

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A novel fluorescent aptasensor based on exonuclease-assisted triple recycling amplification for sensitive and label-free detection of aflatoxin B1

Authors: Hao Wu, Hongyong Wang, Jun Wu, Guoqing Han, Yaling Liu, Pei Zou

Journal: J Hazard Mater.

PubMed ID: 33743380

Doi: 10.1016/j.jhazmat.2021.125584

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Cancer-associated fibroblasts-derived exosomal miR-3656 promotes the development and progression of esophageal squamous cell carcinoma via the ACAP2/PI3K-AKT signaling pathway

Authors: Yuan Jin, Qilin Meng, Bihui Zhang, Chen Xie, Xue Chen, Baoqing Tian, Jiakang Wang, Tsung-Chieh Shih, Yibo Zhang, Jieqiong Cao, Yiqi Yang, Size Chen, Xinyuan Guan, Xiaojia Chen, An Hong

Journal: Int J Biol Sci

PubMed ID: 34671193

Doi: 10.7150/ijbs.62571

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Helicase-AID: A novel molecular device for base editing at random genomic loci

Authors: Jie Wang, Dongdong Zhao, Ju Li, Muzi Hu, Xiuqing Xin, Marcus A Price, Qingyan Li, Li Liu, Siwei Li, Susan J Rosser, Chunzhi Zhang, Changhao Bi, Xueli Zhang

Journal: Metab Eng

PubMed ID: 34411701

Doi: 10.1016/j.ymben.2021.08.005

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Sclerotinia sclerotiorum Thioredoxin1 (SsTrx1) is required for pathogenicity and oxidative stress tolerance

Authors: Kusum Rana, Yijuan Ding, Surinder S Banga, Hongmei Liao, Siqi Zhao, Yang Yu, Wei Qian

Journal: Mol Plant Pathol

PubMed ID: 34459563

Doi: 10.1111/mpp.13127

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Expression and characterization of a novel lipase from Bacillus licheniformis NCU CS-5 for application in enhancing fatty acids flavor release for low-fat cheeses

Authors: Junxin Zhao, Maomao Ma, Xianghui Yan, Guohua Zhang, Jiaheng Xia, Guibing Zeng, Wenran Tian, Xianliang Bao, Zheling Zeng, Ping Yu, Deming Gong

Journal: Food Chem

PubMed ID: 34438173

Doi: 10.1016/j.foodchem.2021.130868

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Determine genetic variations in heat shock factor gene family (HSFs) and study their effect on the functional and structural characterization of protein in Tali goat

Authors: Elham Rezvannejad, Seyed Azim Mousavizadeh, Safa Lotfi, Najmeh Kargar

Journal: Anim Biotechnol

PubMed ID: 34370605

Doi: 10.1080/10495398.2021.1954935

Molecular Context of Dopa Influences Adhesion of Mussel-Inspired Peptides

Authors: George D Degen, Keila C Cunha, Zachary A Levine, J Herbert Waite, Joan-Emma Shea

Journal: J Phys Chem B

PubMed ID: 34459591

Doi: 10.1021/acs.jpcb.1c05218

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Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition

Authors: Ning Wu, Zhi Li, Jing Wang, Lihua Geng, Yang Yue, Zhenzhen Deng, Qingchi Wang, Quanbin Zhang

Journal: Carbohydr Polym

PubMed ID: 34560978

Doi: 10.1016/j.carbpol.2021.118567

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Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca levels

Authors: Ferdinand F Fatiga, Li-Jie Wang, Tian Hsu, Jenica Irish Capuno, Chi-Yu Fu

Journal: J Cell Biochem

PubMed ID: 34431132

Doi: 10.1002/jcb.30138

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Light-Responsive Dynamic Protein Hydrogels Based on LOVTRAP

Authors: Tianyu Duan, Qingyuan Bian, Hongbin Li

Journal: Langmuir

PubMed ID: 34396769

Doi: 10.1021/acs.langmuir.1c01699

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Merlin functions as a critical regulator in Staphylococcus aureus-induced osteomyelitis

Authors: Zubin Zhou, Yuanliang Chen, Hong Sung Min, Yongbai Wan, Haojie Shan, Yiwei Lin, Wenyang Xia, Fuli Yin, Chaolai Jiang, Xiaowei Yu

Journal: J Cell Physiol

PubMed ID: 34378805

Doi: 10.1002/jcp.30550

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Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution

Authors: Andreia M Silva, Elisa Lázaro-Ibáñez, Anders Gunnarsson, Aditya Dhande, George Daaboul, Ben Peacock, Xabier Osteikoetxea, Nikki Salmond, Kristina Pagh Friis, Olga Shatnyeva, Niek Dekker

Journal: J Extracell Vesicles

PubMed ID: 34377376

Doi: 10.1002/jev2.12130

Products & Services: Proteins, Expression, Isolation and Analysis

An Ancestral Retrovirus Envelope Protein Regulates Persistent Gammaherpesvirus Lifecycles

Authors: Tiffany R Frey, Ibukun A Akinyemi, Eric M Burton, Sumita Bhaduri-McIntosh, Michael T McIntosh

Journal: Front Microbiol

PubMed ID: 34434177

Doi: 10.3389/fmicb.2021.708404

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Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from

Authors: Zahra Najarzadeh, Janni Nielsen, Azad Farzadfard, Vita Sereikaite, Kristian Strømgaard, Rikke Louise Meyer, Daniel Erik Otzen

Journal: ACS Omega

PubMed ID: 34497891

Doi: 10.1021/acsomega.1c02333

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() Could Inhibit the Proliferation of Nucleopolyhedrovirus through Promoting Apoptosis

Authors: Jie Wang, Lin-Bao Zhu, Yan Ma, Ying-Xue Liu, Hui-Hua Cao, Yu-Ling Wang, Xue Kong, Zhi-Hao Huang, Han-Dan Zhu, Yan-Xiang Wang, Shi-Huo Liu, Jia-Ping Xu

Journal: Insects

PubMed ID: 34442307

Doi: 10.3390/insects12080743

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