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MiR-199b-5p Promotes Gastric Cancer Progression by Regulating HHIP Expression

Authors: Songda Chen, Huijie Wu, Lingyu Zhu, Mengjie Jiang, Shuli Wei, Jinhua Luo, Aiqun Liu

Journal: Front Oncol

PubMed ID: 34532291

Doi: 10.3389/fonc.2021.728393

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Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models

Authors: Anja Schulze-Krebs, Fabio Canneva, Judith Stemick, Anne-Christine Plank, Julia Harrer, Gillian P Bates, Daniel Aeschlimann, Joan S Steffan, Stephan von Hörsten

Journal: Int J Mol Sci

PubMed ID: 34445621

Doi: 10.3390/ijms22168914

Products & Services: Mutant Libraries

Mechanism of Anti-Inflammatory Activity of TLR4-Interacting SPA4 Peptide

Authors: Shanjana Awasthi, Gaurav Kumar, Vijay Ramani, Vibhudutta Awasthi, Karla K Rodgers, Jun Xie, Jacob Beierle, Gertrude Kyere-Davies, Bhupinder Singh, Negar Rahman, Asif Alam Chowdhury, Neha Chataut

Journal: Immunohorizons

PubMed ID: 34429343

Doi: 10.4049/immunohorizons.2100067

Products & Services: Mutant Libraries

Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction

Authors: Armando Estrada, Alejandro C Rodriguez, Georgialina Rodriguez, Alice H Grant, Yoshira M Ayala-Marin, Amy J Arrieta, Robert A Kirken

Journal: Sci Rep

PubMed ID: 34417497

Doi: 10.1038/s41598-021-96428-y

Products & Services: Mammalian Expression

Circular RNA FNDC3B Protects Oral Squamous Cell Carcinoma Cells From Ferroptosis and Contributes to the Malignant Progression by Regulating miR-520d-5p/SLC7A11 Axis

Authors: Jie Yang, Xing-Hua Cao, Ke-Feng Luan, Yun-Dong Huang

Journal: Front Oncol

PubMed ID: 34434890

Doi: 10.3389/fonc.2021.672724

Products & Services: Mammalian Expression

A Widespread Bacterial Secretion System with Diverse Substrates

Authors: Alex S Grossman, Terra J Mauer, Katrina T Forest, Heidi Goodrich-Blair

Journal: MBio.

PubMed ID: 34399622

Doi: 10.1128/mBio.01956-21

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Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor

Authors: Kim Ghilarducci, Valérie C Cabana, Camille Desroches, Kahina Chabi, Steve Bourgault, Laurent Cappadocia, Marc P Lussier

Journal: FEBS J

PubMed ID: 33650289

Doi: 10.1111/febs.15796

Products & Services: Gene Synthesis

Live-cell imaging of microRNA expression with post-transcriptional feedback control

Authors: Masayuki Sano, Kana Morishita, Satoshi Oikawa, Takayuki Akimoto, Kimio Sumaru, Yoshio Kato

Journal: Mol Ther Nucleic Acids

PubMed ID: 34631284

Doi: 10.1016/j.omtn.2021.08.018

Products & Services: Mammalian Expression

Identification of the Biosynthetic Gene Cluster for the Organoarsenical Antibiotic Arsinothricin

Authors: Adriana E Galván, Ngozi P Paul, Jian Chen, Kunie Yoshinaga-Sakurai, Sagar M Utturkar, Barry P Rosen, Masafumi Yoshinaga

Journal: Microbiol Spectr

PubMed ID: 34378964

Doi: 10.1128/Spectrum.00502-21

Products & Services: Mammalian Expression

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Authors: Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo, Qiwei Zhang, Jianguo Wu

Journal: Signal Transduct Target Ther

PubMed ID: 34408131

Doi: 10.1038/s41392-021-00726-w

Products & Services: GenParts™ DNA Fragments

Aptamer-Integrated Scaffolds for Biologically Functional DNA Origami Structures

Authors: Xiaoxing Chen, Bin Jia, Zhangwei Lu, Libing Liao, Hanyang Yu, Zhe Li

Journal: ACS Appl Mater Interfaces

PubMed ID: 34402304

Doi: 10.1021/acsami.1c09307

Products & Services: GenParts™ DNA Fragments

Exploring functionality of the reverse β-oxidation pathway in Corynebacterium glutamicum for production of adipic acid

Authors: Jae Ho Shin, Aaron John Christian Andersen, Puck Achterberg, Lisbeth Olsson

Journal: Microb Cell Fact

PubMed ID: 34348702

Doi: 10.1186/s12934-021-01647-7

Products & Services: Gene Synthesis

A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice

Authors: Arshad Khan, Ekramy E Sayedahmed, Vipul K Singh, Abhishek Mishra, Stephanie Dorta-Estremera, Sita Nookala, David H Canaday, Min Chen, Jin Wang, K Jagannadha Sastry, Suresh K Mittal, Chinnaswamy Jagannath

Journal: Cell Rep Med

PubMed ID: 34467249

Doi: 10.1016/j.xcrm.2021.100372

Products & Services: Gene Synthesis

Der f 38 Is a Novel TLR4-Binding Allergen Related to Allergy Pathogenesis from

Authors: Geunyeong Kim, Minhwa Hong, Ayesha Kashif, Yujin Hong, Beom-Seok Park, Ji-Young Mun, Hyosun Choi, Ji-Sook Lee, Eun-Ju Yang, Ran-Sook Woo, Soo-Jin Lee, Minseo Yang, In-Sik Kim

Journal: Int J Mol Sci

PubMed ID: 34445142

Doi: 10.3390/ijms22168440

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Decisive Effects of Life Stage on the Gut Microbiota Discrepancy Between Two Wild Populations of Hibernating Asiatic Toads ()

Authors: Xiaowei Song, Jingwei Zhang, Jinghan Song, Yuanyuan Zhai

Journal: Front Microbiol

PubMed ID: 34413833

Doi: 10.3389/fmicb.2021.665849

Products & Services: DNA Sequencing

Functionalizing Cell-Free Systems with CRISPR-Associated Proteins: Application to RNA-Based Circuit Engineering

Authors: François-Xavier Lehr, Alina Kuzembayeva, Megan E Bailey, Werner Kleindienst, Johannes Kabisch, Heinz Koeppl

Journal: ACS Synth Biol

PubMed ID: 34383464

Doi: 10.1021/acssynbio.0c00386

Products & Services: DNA Sequencing

Development of a real-time recombinase-aided amplification (RT-RAA) molecular diagnosis assay for sensitive and rapid detection of Toxoplasma gondii

Authors: Zhao-Hua Wang, Wei Zhang, Xiu-Zhong Zhang, Xin-Ran Yao, Wei Huang, Hong Jia, Xiao-Lei Liu, Shao-Hua Hou, Xiao-Jia Wang

Journal: Vet Parasitol

PubMed ID: 34384956

Doi: 10.1016/j.vetpar.2021.109489

Products & Services: DNA Sequencing

Engineering entropy-driven based multiple signal amplification strategy for visualized assay of miRNA by naked eye

Authors: Sha Zhu, Yi Qi Yang, Yuedi Ding, Ninghan Feng, Menglu Li, Yongmei Yin

Journal: Talanta

PubMed ID: 34517667

Doi: 10.1016/j.talanta.2021.122810

Products & Services: DNA Sequencing

Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease

Authors: Xiaoyu Qi, Anping Song, Mingyue Ma, Peipei Wang, Xinbei Zhang, Chunfeng Lu, Junxiu Zhang, Shuguo Zheng, Huanhuan Jin

Journal: Cell Prolif

PubMed ID: 34346124

Doi: 10.1111/cpr.13107

Products & Services: DNA Sequencing

MiR-590-5p inhibits pathological hypertrophy mediated heart failure by targeting RTN4

Authors: Ping Fan, Likun Zhang, Tianyu Cheng, Jing Wang, Junyun Zhou, Li Zhao, Cuie Hua, Quan Xia

Journal: J Mol Histol

PubMed ID: 34406553

Doi: 10.1007/s10735-021-10009-x

Products & Services: DNA Sequencing

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

Authors: Yanyun Du, Rui Shi, Ying Zhang, Xiaomin Duan, Li Li, Jing Zhang, Fengze Wang, Ruixue Zhang, Hao Shen, Yue Wang, Zheng Wu, Qianwen Peng, Ting Pan, Wanwei Sun, Weijin Huang, Yue Feng, Hui Feng, Junyu Xiao, Wenjie Tan, Youchun Wang, Chenhui Wang, Jinghua Yan

Journal: Nat Commun

PubMed ID: 34404805

Doi: 10.1038/s41467-021-25331-x

Products & Services: DNA Sequencing

Blocking HSV-1 glycoprotein K binding to signal peptide peptidase reduces virus infectivity in vitro and in vivo

Authors: Shaohui Wang, Ujjaldeep Jaggi, Jack Yu, Homayon Ghiasi

Journal: PLoS Pathog

PubMed ID: 34352042

Doi: 10.1371/journal.ppat.1009848

Products & Services: DNA Sequencing

Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro

Authors: Juliana C Ferreira, Samar Fadl, Metehan Ilter, Hanife Pekel, Rachid Rezgui, Ozge Sensoy, Wael M Rabeh

Journal: FASEB J

PubMed ID: 34324734

Doi: 10.1096/fj.202100994

Products & Services: Custom Vector Construction

Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

Authors: Serdar Durdagi, Çağdaş Dağ, Berna Dogan, Merve Yigin, Timucin Avsar, Cengizhan Buyukdag, Ismail Erol, Fatma Betul Ertem, Seyma Calis, Gunseli Yildirim, Muge D Orhan, Omur Guven, Busecan Aksoydan, Ebru Destan, Kader Sahin, Sabri O Besler, Lalehan Oktay, Alaleh Shafiei, Ilayda Tolu, Esra Ayan, Busra Yuksel, Ayse B Peksen, Oktay Gocenler, Ali D Yucel, Ozgur Can, Serena Ozabrahamyan, Alpsu Olkan, Ece Erdemoglu, Fulya Aksit, Gokhan Tanisali, Oleksandr M Yefanov, Anton Barty, Alexandra Tolstikova, Gihan K Ketawala, Sabine Botha, E Han Dao, Brandon Hayes, Mengning Liang, Matthew H Seaberg, Mark S Hunter, Alex Batyuk, Valerio Mariani, Zhen Su, Frederic Poitevin, Chun Hong Yoon, Christopher Kupitz, Raymond G Sierra, Edward H Snell, Hasan DeMirci

Journal: Structure

PubMed ID: 34403647

Doi: 10.1016/j.str.2021.07.007

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An epigenetic basis of inbreeding depression in maize

Authors: Tongwen Han, Fang Wang, Qingxin Song, Wenxue Ye, Tieshan Liu, Liming Wang, Z Jeffrey Chen

Journal: Sci Adv

PubMed ID: 34452913

Doi: 10.1126/sciadv.abg5442

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DEAE-chitosan nanoparticles as a pneumococcus-biomimetic material for the development of antipneumococcal therapeutics

Authors: Roberto Vázquez, Francisco J Caro-León, Alberto Nakal, Susana Ruiz, Carmen Doñoro, Luis García-Fernández, Blanca Vázquez-Lasa, Julio San Román, Jesús Sanz, Pedro García, María Rosa Aguilar

Journal: Carbohydr Polym

PubMed ID: 34561005

Doi: 10.1016/j.carbpol.2021.118605

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Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions

Authors: Anastasiia Sukalskaia, Monique S Straub, Dawid Deneka, Marta Sawicka, Raimund Dutzler

Journal: Nat Commun

PubMed ID: 34385445

Doi: 10.1038/s41467-021-25106-4

Products & Services: Codon Optimization

The Oxoglutarate Binding Site and Regulatory Mechanism Are Conserved in Ammonium Transporter Inhibitors GlnKs from

Authors: Marie-Caroline Müller, Tristan Wagner

Journal: Int J Mol Sci

PubMed ID: 34445335

Doi: 10.3390/ijms22168631

Products & Services: Codon Optimization

Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice

Authors: Pavlina Chuntova, Yafei Hou, Ryosuke Naka, Akane Yamamichi, Tiffany Chen, Yitzhar Goretsky, Ryusuke Hatae, Takahide Nejo, Gary Kohanbash, Abigail L Mende, Megan Montoya, Kira M Downey, David Diebold, Jayne Skinner, Hong-Erh Liang, Bjoern Schwer, Hideho Okada

Journal: Neuro Oncol

PubMed ID: 34347086

Doi: 10.1093/neuonc/noab182

Products & Services: Codon Optimization

RGD-pectin microfiber patches for guiding muscle tissue regeneration

Authors: Chiara Emma Campiglio, Anna Carcano, Lorenza Draghi

Journal: J Biomed Mater Res A

PubMed ID: 34423891

Doi: 10.1002/jbm.a.37301

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Proteogenomic Analysis Unveils the HLA Class I-Presented Immunopeptidome in Melanoma and EGFR-Mutant Lung Adenocarcinoma

Authors: Yue A Qi, Tapan K Maity, Constance M Cultraro, Vikram Misra, Xu Zhang, Catherine Ade, Shaojian Gao, David Milewski, Khoa D Nguyen, Mohammad H Ebrahimabadi, Ken-Ichi Hanada, Javed Khan, Cenk Sahinalp, James C Yang, Udayan Guha

Journal: Mol Cell Proteomics

PubMed ID: 34391887

Doi: 10.1016/j.mcpro.2021.100136

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ELMO1 signaling is a promoter of osteoclast function and bone loss

Authors: Sanja Arandjelovic, Justin S A Perry, Ming Zhou, Adam Ceroi, Igor Smirnov, Scott F Walk, Laura S Shankman, Isabelle Cambré, Suna Onengut-Gumuscu, Dirk Elewaut, Thomas P Conrads, Kodi S Ravichandran

Journal: Nat Commun

PubMed ID: 34404802

Doi: 10.1038/s41467-021-25239-6

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UbiD domain dynamics underpins aromatic decarboxylation

Authors: Stephen A Marshall, Karl A P Payne, Karl Fisher, Gabriel R Titchiner, Colin Levy, Sam Hay, David Leys

Journal: Nat Commun

PubMed ID: 34417452

Doi: 10.1038/s41467-021-25278-z

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BioParts-A Biological Parts Search Portal and Updates to the ICE Parts Registry Software Platform

Authors: Hector A Plahar, Thomas N Rich, Stephen D Lane, William C Morrell, Leanne Springthorpe, Oge Nnadi, Elena Aravina, Tiffany Dai, Michael J Fero, Nathan J Hillson, Christopher J Petzold

Journal: ACS Synth Biol

PubMed ID: 34449214

Doi: 10.1021/acssynbio.1c00263

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Bone developmental toxicity of organophosphorus flame retardants TDCIPP and TPhP in marine medaka Oryzias melastigma

Authors: Haizheng Hong, Yunchen Zhao, Lingming Huang, Daiyin Zhong, Dalin Shi

Journal: Ecotoxicol Environ Saf

PubMed ID: 34371453

Doi: 10.1016/j.ecoenv.2021.112605

Products & Services: Gene Synthesis

E-cadherin activating antibodies limit barrier dysfunction and inflammation in mouse inflammatory bowel disease

Authors: Chirosree Bandyopadhyay, Leslayann Schecterson, Barry M Gumbiner

Journal: Tissue barriers

PubMed ID: 34402758

Doi: 10.1080/21688370.2021.1940741

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Analysis of the Manganese and MntR Regulon in Corynebacterium diphtheriae

Authors: Eric D Peng, Lindsey R Lyman, Michael P Schmitt

Journal: J Bacteriol

PubMed ID: 34370555

Doi: 10.1128/JB.00274-21

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Generation of hypoxia-sensing chimeric antigen receptor T cells

Authors: Paris Kosti, Karen I Larios-Martinez, John Maher, James N Arnold

Journal: STAR Protoc

PubMed ID: 34401788

Doi: 10.1016/j.xpro.2021.100723

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Inhibitory Compounds Targeting Plasmodium falciparum Gyrase B

Authors: Zuzanna Pakosz, Ting-Yu Lin, Elizabeth Michalczyk, Soshichiro Nagano, Jonathan Gardiner Heddle

Journal: Antimicrob Agents Chemother

PubMed ID: 34339271

Doi: 10.1128/AAC.00267-21

Products & Services: Proteins, Expression, Isolation and Analysis

Design of Broadly Cross-Reactive M Protein-Based Group A Streptococcal Vaccines

Authors: Michelle P Aranha, Thomas A Penfound, Sanaz Salehi, Anne Botteaux, Pierre Smeesters, James B Dale, Jeremy C Smith

Journal: J Immunol

PubMed ID: 34341168

Doi: 10.4049/jimmunol.2100286

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Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress

Authors: Lauren E Williamson, Kristen M Reeder, Kevin Bailey, Minh H Tran, Vicky Roy, Mallorie E Fouch, Nurgun Kose, Andrew Trivette, Rachel S Nargi, Emma S Winkler, Arthur S Kim, Christopher Gainza, Jessica Rodriguez, Erica Armstrong, Rachel E Sutton, Joseph Reidy, Robert H Carnahan, W Hayes McDonald, Clara T Schoeder, William B Klimstra, Edgar Davidson, Benjamin J Doranz, Galit Alter, Jens Meiler, Kevin L Schey, Justin G Julander, Michael S Diamond, James E Crowe

Journal: Cell

PubMed ID: 34416147

Doi: 10.1016/j.cell.2021.07.033

Products & Services: Plasmid DNA Preparation

Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium yoelii liver stage

Authors: Kamalakannan Vijayan, Ganesh Ram R Visweswaran, Ramyavardhanee Chandrasekaran, Olesya Trakhimets, Samantha L Brown, Alexander Watson, Meghan Zuck, Nicholas Dambrauskas, Andrew Raappana, Sara Carbonetti, Laurel Kelnhofer-Millevolte, Elizabeth K K Glennon, Rachel Postiglione, D Noah Sather, Alexis Kaushansky

Journal: Cell Rep

PubMed ID: 34348141

Doi: 10.1016/j.celrep.2021.109489

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iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation

Authors: Danielle M Garshott, Heeseon An, Elayanambi Sundaramoorthy, Marilyn Leonard, Alison Vicary, J Wade Harper, Eric J Bennett

Journal: Cell Rep

PubMed ID: 34469731

Doi: 10.1016/j.celrep.2021.109642

Products & Services: Proteins, Expression, Isolation and Analysis

NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms

Authors: Zikai Zhou, Guiqin He, Xiaoyun Zhang, Xin Lv, Xiaolin Zhang, An Liu, Shuting Xia, Hao Xie, Rui Dang, Lifang Han, Junxia Qi, Yanghong Meng, Shunying Yu, Wei Xie, Zhengping Jia

Journal: Cell Rep

PubMed ID: 34407403

Doi: 10.1016/j.celrep.2021.109515

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A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity

Authors: Krishna Das, Elodie Belnoue, Matteo Rossi, Tamara Hofer, Sarah Danklmaier, Tobias Nolden, Liesa-Marie Schreiber, Katharina Angerer, Janine Kimpel, Sandra Hoegler, Bart Spiesschaert, Lukas Kenner, Dorothee von Laer, Knut Elbers, Madiha Derouazi, Guido Wollmann

Journal: Nat Commun

PubMed ID: 34465781

Doi: 10.1038/s41467-021-25506-6

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Structural basis for Ca activation of the heteromeric PKD1L3/PKD2L1 channel

Authors: Qiang Su, Mengying Chen, Yan Wang, Bin Li, Dan Jing, Xiechao Zhan, Yong Yu, Yigong Shi

Journal: Nat Commun

PubMed ID: 34381056

Doi: 10.1038/s41467-021-25216-z

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Systematic Genome-Wide Study and Expression Analysis of Gene Family: Sugar Transporter Family Contributes to Biotic and Abiotic Stimuli in Watermelon

Authors: Changqing Xuan, Guangpu Lan, Fengfei Si, Zhilong Zeng, Chunxia Wang, Vivek Yadav, Chunhua Wei, Xian Zhang

Journal: Int J Mol Sci

PubMed ID: 34445115

Doi: 10.3390/ijms22168407

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Extremely short bioavailability and fast pharmacodynamic effects of pMHC-based nanomedicines

Authors: Yang Yang, Kristofor K Ellestad, Santiswarup Singha, Muhammad Myn Uddin, Robert Clarke, Debajyoti Mondal, Nahir Garabatos, Patricia Solé, Cesar Fandos, Pau Serra, Pere Santamaria

Journal: J Control Release

PubMed ID: 34474072

Doi: 10.1016/j.jconrel.2021.08.043

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A resource of high-quality and versatile nanobodies for drug delivery

Authors: Zhuolun Shen, Yufei Xiang, Sandra Vergara, Apeng Chen, Zhengyun Xiao, Ulises Santiago, Changzhong Jin, Zhe Sang, Jiadi Luo, Kong Chen, Dina Schneidman-Duhovny, Carlos Camacho, Guillermo Calero, Baoli Hu, Yi Shi

Journal: iScience

PubMed ID: 34522857

Doi: 10.1016/j.isci.2021.103014

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Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

Authors: Juanjie Tang, Youri Lee, Supriya Ravichandran, Gabrielle Grubbs, Chang Huang, Charles B Stauft, Tony Wang, Basil Golding, Hana Golding, Surender Khurana

Journal: iScience

PubMed ID: 34430803

Doi: 10.1016/j.isci.2021.103006

Products & Services: Recombinant Proteins

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