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SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

Authors: Jiří Zahradník, Shir Marciano, Maya Shemesh, Eyal Zoler, Daniel Harari, Jeanne Chiaravalli, Björn Meyer, Yinon Rudich, Chunlin Li, Ira Marton, Orly Dym, Nadav Elad, Mark G Lewis, Hanne Andersen, Matthew Gagne, Robert A Seder, Daniel C Douek, Gideon Schreiber

Journal: Nat Microbiol

PubMed ID: 34400835

Doi: 10.1038/s41564-021-00954-4

Products & Services: Stable Cell Lines

Molecular mechanisms of centipede toxin SsTx-4 inhibition of inwardly rectifying potassium channels

Authors: Dongfang Tang, Jiahui Xu, Yinping Li, Piao Zhao, Xiangjin Kong, Haoliang Hu, Songping Liang, Cheng Tang, Zhonghua Liu

Journal: J Biol Chem

PubMed ID: 34391777

Doi: 10.1016/j.jbc.2021.101076

Products & Services: Recombinant Antibody Expression

Influence of Electrolyte Concentration on Single-Molecule Sensing of Perfluorocarboxylic Acids

Authors: Xinyun Yao, Ning-Ning Song, Jia Wang, Xian Zhao, Meng-Yuan Cheng, Jiaqi Zuo, Kaipei Qiu

Journal: Front Chem

PubMed ID: 34414165

Doi: 10.3389/fchem.2021.732378

Products & Services: Proteins, Expression, Isolation and Analysis

Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice

Authors: Mingyuan Han, Tomoko Ishikawa, Claudia C Stroupe, Haley A Breckenridge, J Kelley Bentley, Marc B Hershenson

Journal: Mucosal Immunol

PubMed ID: 34354243

Doi: 10.1038/s41385-021-00436-0

Products & Services: Mammalian Expression

Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions

Authors: Michael C Yoon, Angelo Solania, Zhenze Jiang, Mitchell P Christy, Sonia Podvin, Charles Mosier, Christopher B Lietz, Gen Ito, William H Gerwick, Dennis W Wolan, Gregory Hook, Anthony J O'Donoghue, Vivian Hook

Journal: ACS Chem Biol

PubMed ID: 34416110

Doi: 10.1021/acschembio.1c00138

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Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway

Authors: Feifei Huang, Tianyun Gao, Wenqing Wang, Liudi Wang, Yuanyuan Xie, Chenxun Tai, Shuo Liu, Yi Cui, Bin Wang

Journal: Stem Cell Res Ther

PubMed ID: 34419172

Doi: 10.1186/s13287-021-02537-w

Products & Services: DNA Sequencing

Proteome-Wide Profiling of Readers for DNA Modification

Authors: Lin Bai, Guojian Yang, Zhaoyu Qin, Jiacheng Lyu, Yunzhi Wang, Jinwen Feng, Mingwei Liu, Tongqing Gong, Xianju Li, Zhengyang Li, Jixi Li, Jun Qin, Wenjun Yang, Chen Ding

Journal: Adv Sci (Weinh)

PubMed ID: 34351703

Doi: 10.1002/advs.202101426

Products & Services: Custom DNA/RNA Oligos

Genome-Wide Characterization and Expression Analysis Provide Basis to the Biological Function of Cotton FBA Genes

Authors: Zhong-Qing Li, Yao Zhang, He Li, Ting-Ting Su, Cheng-Gong Liu, Zi-Chao Han, Ai-Ying Wang, Jian-Bo Zhu

Journal: Front Plant Sci

PubMed ID: 34490001

Doi: 10.3389/fpls.2021.696698

Products & Services: Protein Tools

Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene

Authors: Melanie L Bailey, David Tieu, Andrea Habsid, Amy Hin Yan Tong, Katherine Chan, Jason Moffat, Philip Hieter

Journal: Life Sci Alliance

PubMed ID: 34462321

Doi: 10.26508/lsa.202101083

Products & Services: DNA Sequencing

Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

Authors: Fei Liu, Amy C H Lee, Fang Guo, Andrew S Kondratowicz, Holly M Micolochick Steuer, Angela Miller, Lauren D Bailey, Xiaohe Wang, Shuai Chen, Steven G Kultgen, Andrea Cuconati, Andrew G Cole, Dimitar Gotchev, Bruce D Dorsey, Rene Rijnbrand, Angela M Lam, Michael J Sofia, Min Gao

Journal: J Virol

PubMed ID: 34191584

Doi: 10.1128/JVI.00574-21

Products & Services: Gene Synthesis

Design of Broadly Cross-Reactive M Protein-Based Group A Streptococcal Vaccines

Authors: Michelle P Aranha, Thomas A Penfound, Sanaz Salehi, Anne Botteaux, Pierre Smeesters, James B Dale, Jeremy C Smith

Journal: J Immunol

PubMed ID: 34341168

Doi: 10.4049/jimmunol.2100286

Products & Services: Gene Synthesis

-Specific T Cell Functional, Memory, and Activation Profiles in QuantiFERON-Reverters Are Consistent With Controlled Infection

Authors: Cheleka A M Mpande, Pia Steigler, Tessa Lloyd, Virginie Rozot, Boitumelo Mosito, Constance Schreuder, Timothy D Reid, Nicole Bilek, Morten Ruhwald, Jason R Andrews, Mark Hatherill, Francesca Little, Thomas J Scriba, Elisa Nemes

Journal: Front Immunol

PubMed ID: 34526988

Doi: 10.3389/fimmu.2021.712480

Products & Services: Catalog Antibody

Longitudinal Follow-up of Antibody Responses in Pediatric Patients With COVID-19 up to 9 Months After Infection

Authors: Pembe Derin Oygar, Yasemin Ozsurekci, Sibel Lacinel Gurlevik, Kubra Aykac, Musa Gurel Kukul, Burcu Ceylan Cura Yayla, Sare Ilbay, Jale Karakaya, Ozlem Teksam, Ali Bulent Cengiz, Mehmet Ceyhan

Journal: Pediatr Infect Dis J

PubMed ID: 34250968

Doi: 10.1097/INF.0000000000003199

Products & Services: Proteins, Expression, Isolation and Analysis

Synthesis of precision antibody conjugates using proximity-induced chemistry

Authors: Yu J Cao, Chenfei Yu, Kuan-Lin Wu, Xuechun Wang, Dong Liu, Zeru Tian, Lijun Zhao, Xuexiu Qi, Axel Loredo, Anna Chung, Han Xiao

Journal: Theranostics

PubMed ID: 34522229

Doi: 10.7150/thno.62444

Products & Services: Recombinant Proteins

Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation

Authors: Caixia Liu, Benlong Cai, Dan Li, Yuan Yao

Journal: Innate Immun

PubMed ID: 34428935

Doi: 10.1177/17534259211035426

Products & Services: Custom Vector Construction

Influence of in vitro neuronal membranes on the anti-amyloidogenic activity of gallic acid: Implication for the therapy of Alzheimer's disease

Authors: Stéphanie Andrade, Joana Angélica Loureiro, Maria do Carmo Pereira

Journal: Arch Biochem Biophys

PubMed ID: 34461085

Doi: 10.1016/j.abb.2021.109022

Products & Services: Mammalian Expression

Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru

Authors: Luis M Jara, Cusi Ferradas, Francesca Schiaffino, Camila Sánchez-Carrión, Ana Martínez-Vela, Alexandra Ulloa, Gisela Isasi-Rivas, Angela Montalván, Luis Guevara Sarmiento, Manolo Fernández, Mirko Zimic

Journal: One Health

PubMed ID: 34462726

Doi: 10.1016/j.onehlt.2021.100318

Products & Services: Proteins, Expression, Isolation and Analysis

Activation of gene expression by detergent-like protein domains

Authors: Bradley K Broyles, Andrew T Gutierrez, Theodore P Maris, Daniel A Coil, Thomas M Wagner, Xiao Wang, Daisuke Kihara, Caleb A Class, Alexandre M Erkine

Journal: iScience

PubMed ID: 34522860

Doi: 10.1016/j.isci.2021.103017

Products & Services: Molecular Biology Reagents

A novel pine wood nematode effector, BxSCD1, suppresses plant immunity and interacts with an ethylene-forming enzyme in pine

Authors: Tong-Yue Wen, Xiao-Qin Wu, Long-Jiao Hu, Yi-Jun Qiu, Lin Rui, Yan Zhang, Xiao-Lei Ding, Jian-Ren Ye

Journal: Mol Plant Pathol

PubMed ID: 34396673

Doi: 10.1111/mpp.13121

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia

Authors: Jan-Erik Messling, Karl Agger, Kasper L Andersen, Kristina Kromer, Hanna Maria Kuepper, Anders H Lund, Kristian Helin

Journal: Blood

PubMed ID: 34359076

Doi: 10.1182/blood.2021012629

Products & Services: Oligo pool

How to Sequence Therapies in Waldenström Macroglobulinemia

Authors: Shayna Sarosiek, Steven P Treon, Jorge J Castillo

Journal: Curr Treat Options Oncol

PubMed ID: 34426943

Doi: 10.1007/s11864-021-00890-9

Products & Services: Protein Reagents and Products

Glucagon-like peptide-1 receptor controls exocytosis in chromaffin cells by increasing full-fusion events

Authors: Ayoze González-Santana, Judith Estévez-Herrera, Elizabeth P Seward, Ricardo Borges, José David Machado

Journal: Cell Rep

PubMed ID: 34433018

Doi: 10.1016/j.celrep.2021.109609

Products & Services: PCR and Cloning

A novel fluorescent aptasensor based on exonuclease-assisted triple recycling amplification for sensitive and label-free detection of aflatoxin B1

Authors: Hao Wu, Hongyong Wang, Jun Wu, Guoqing Han, Yaling Liu, Pei Zou

Journal: J Hazard Mater.

PubMed ID: 33743380

Doi: 10.1016/j.jhazmat.2021.125584

Products & Services: Custom DNA/RNA Oligos

Cancer-associated fibroblasts-derived exosomal miR-3656 promotes the development and progression of esophageal squamous cell carcinoma via the ACAP2/PI3K-AKT signaling pathway

Authors: Yuan Jin, Qilin Meng, Bihui Zhang, Chen Xie, Xue Chen, Baoqing Tian, Jiakang Wang, Tsung-Chieh Shih, Yibo Zhang, Jieqiong Cao, Yiqi Yang, Size Chen, Xinyuan Guan, Xiaojia Chen, An Hong

Journal: Int J Biol Sci

PubMed ID: 34671193

Doi: 10.7150/ijbs.62571

Products & Services: DNA Sequencing

Helicase-AID: A novel molecular device for base editing at random genomic loci

Authors: Jie Wang, Dongdong Zhao, Ju Li, Muzi Hu, Xiuqing Xin, Marcus A Price, Qingyan Li, Li Liu, Siwei Li, Susan J Rosser, Chunzhi Zhang, Changhao Bi, Xueli Zhang

Journal: Metab Eng

PubMed ID: 34411701

Doi: 10.1016/j.ymben.2021.08.005

Products & Services: DNA Sequencing

Sclerotinia sclerotiorum Thioredoxin1 (SsTrx1) is required for pathogenicity and oxidative stress tolerance

Authors: Kusum Rana, Yijuan Ding, Surinder S Banga, Hongmei Liao, Siqi Zhao, Yang Yu, Wei Qian

Journal: Mol Plant Pathol

PubMed ID: 34459563

Doi: 10.1111/mpp.13127

Products & Services: Custom RNAi Services

Expression and characterization of a novel lipase from Bacillus licheniformis NCU CS-5 for application in enhancing fatty acids flavor release for low-fat cheeses

Authors: Junxin Zhao, Maomao Ma, Xianghui Yan, Guohua Zhang, Jiaheng Xia, Guibing Zeng, Wenran Tian, Xianliang Bao, Zheling Zeng, Ping Yu, Deming Gong

Journal: Food Chem

PubMed ID: 34438173

Doi: 10.1016/j.foodchem.2021.130868

Products & Services: Codon Optimization

Determine genetic variations in heat shock factor gene family (HSFs) and study their effect on the functional and structural characterization of protein in Tali goat

Authors: Elham Rezvannejad, Seyed Azim Mousavizadeh, Safa Lotfi, Najmeh Kargar

Journal: Anim Biotechnol

PubMed ID: 34370605

Doi: 10.1080/10495398.2021.1954935

Molecular Context of Dopa Influences Adhesion of Mussel-Inspired Peptides

Authors: George D Degen, Keila C Cunha, Zachary A Levine, J Herbert Waite, Joan-Emma Shea

Journal: J Phys Chem B

PubMed ID: 34459591

Doi: 10.1021/acs.jpcb.1c05218

Products & Services: Catalog Peptides

Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition

Authors: Ning Wu, Zhi Li, Jing Wang, Lihua Geng, Yang Yue, Zhenzhen Deng, Qingchi Wang, Quanbin Zhang

Journal: Carbohydr Polym

PubMed ID: 34560978

Doi: 10.1016/j.carbpol.2021.118567

Products & Services: Recombinant Proteins

Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca levels

Authors: Ferdinand F Fatiga, Li-Jie Wang, Tian Hsu, Jenica Irish Capuno, Chi-Yu Fu

Journal: J Cell Biochem

PubMed ID: 34431132

Doi: 10.1002/jcb.30138

Products & Services: Catalog Antibody

Light-Responsive Dynamic Protein Hydrogels Based on LOVTRAP

Authors: Tianyu Duan, Qingyuan Bian, Hongbin Li

Journal: Langmuir

PubMed ID: 34396769

Doi: 10.1021/acs.langmuir.1c01699

Products & Services: Catalog Antibody

Merlin functions as a critical regulator in Staphylococcus aureus-induced osteomyelitis

Authors: Zubin Zhou, Yuanliang Chen, Hong Sung Min, Yongbai Wan, Haojie Shan, Yiwei Lin, Wenyang Xia, Fuli Yin, Chaolai Jiang, Xiaowei Yu

Journal: J Cell Physiol

PubMed ID: 34378805

Doi: 10.1002/jcp.30550

Products & Services: Custom DNA/RNA Oligos

Quantification of protein cargo loading into engineered extracellular vesicles at single-vesicle and single-molecule resolution

Authors: Andreia M Silva, Elisa Lázaro-Ibáñez, Anders Gunnarsson, Aditya Dhande, George Daaboul, Ben Peacock, Xabier Osteikoetxea, Nikki Salmond, Kristina Pagh Friis, Olga Shatnyeva, Niek Dekker

Journal: J Extracell Vesicles

PubMed ID: 34377376

Doi: 10.1002/jev2.12130

Products & Services: Proteins, Expression, Isolation and Analysis

An Ancestral Retrovirus Envelope Protein Regulates Persistent Gammaherpesvirus Lifecycles

Authors: Tiffany R Frey, Ibukun A Akinyemi, Eric M Burton, Sumita Bhaduri-McIntosh, Michael T McIntosh

Journal: Front Microbiol

PubMed ID: 34434177

Doi: 10.3389/fmicb.2021.708404

Products & Services: Gene Synthesis

Human Fibrinogen Inhibits Amyloid Assembly of Most Phenol-Soluble Modulins from

Authors: Zahra Najarzadeh, Janni Nielsen, Azad Farzadfard, Vita Sereikaite, Kristian Strømgaard, Rikke Louise Meyer, Daniel Erik Otzen

Journal: ACS Omega

PubMed ID: 34497891

Doi: 10.1021/acsomega.1c02333

Products & Services: Peptide Synthesis

() Could Inhibit the Proliferation of Nucleopolyhedrovirus through Promoting Apoptosis

Authors: Jie Wang, Lin-Bao Zhu, Yan Ma, Ying-Xue Liu, Hui-Hua Cao, Yu-Ling Wang, Xue Kong, Zhi-Hao Huang, Han-Dan Zhu, Yan-Xiang Wang, Shi-Huo Liu, Jia-Ping Xu

Journal: Insects

PubMed ID: 34442307

Doi: 10.3390/insects12080743

Products & Services: Recombinant Antibody Expression

Coleopteran-specific StaufenC functions like Loquacious-PD in dsRNA processing

Authors: Kyungbo Kim, Jinmo Koo, June-Sun Yoon, Subba Reddy Palli

Journal: RNA Biol

PubMed ID: 34376105

Doi: 10.1080/15476286.2021.1960687

Products & Services: Recombinant Antibody Expression

Nintedanib downregulates the transition of cultured systemic sclerosis fibrocytes into myofibroblasts and their pro-fibrotic activity

Authors: Maurizio Cutolo, Emanuele Gotelli, Paola Montagna, Samuele Tardito, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldano

Journal: Arthritis Res Ther

PubMed ID: 34344444

Doi: 10.1186/s13075-021-02555-2

Products & Services: Proteins, Expression, Isolation and Analysis

Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders

Authors: Florian Freudenberg, Esin Candemir, Xufeng Chen, Li-Li Li, Dilhan Esen-Sehir, Nicole Schenk, Makoto Kinoshita, Lena Grünewald, Veronika Frerichs, Nikolai Fattakhov, Jessica Manchen, Solmaz Bikas, Anita Kumar, Aet OLeary, David A Slattery, Jakob von Engelhardt, Michael J Courtney, Andreas Reif

Journal: EBioMedicine

PubMed ID: 34455393

Doi: 10.1016/j.ebiom.2021.103565

Products & Services: Proteins, Expression, Isolation and Analysis

Refining the N-Termini of the SARS-CoV-2 Spike Protein and Its Discrete Receptor-Binding Domain

Authors: Robert A D'Ippolito, Matthew R Drew, Jennifer Mehalko, Kelly Snead, Vanessa Wall, Zoe Putman, Dominic Esposito, Caroline J DeHart

Journal: J Proteome Res

PubMed ID: 34379411

Doi: 10.1021/acs.jproteome.1c00349

Products & Services: Proteins, Expression, Isolation and Analysis

Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites

Authors: Devon F Pendlebury, Jingjing Zhang, Ritvija Agrawal, Hiroki Shibuya, Jayakrishnan Nandakumar

Journal: Nat Struct Mol Biol

PubMed ID: 34373645

Doi: 10.1038/s41594-021-00635-0

Products & Services: Proteins, Expression, Isolation and Analysis

Tandem Mass Spectrometry as Strategy for the Selective Identification and Quantification of the Amyloid Precursor Protein Tyr682 Residue Phosphorylation Status in Human Blood Mononuclear Cells

Authors: Pierluigi Reveglia, Rosarita Nasso, Antonella Angiolillo, Lucia Lecce, Carmela Paolillo, Samantha De Tullio, Monica Gelzo, Alfonso Di Costanzo, Carmela Matrone, Gaetano Corso

Journal: Biomolecules

PubMed ID: 34572510

Doi: 10.3390/biom11091297

Products & Services: Peptide Synthesis

HLA Class II Polymorphisms Modulate Gut Microbiota and Experimental Autoimmune Encephalomyelitis Phenotype

Authors: Shailesh K Shahi, Soham Ali, Camille M Jaime, Natalya V Guseva, Ashutosh K Mangalam

Journal: Immunohorizons

PubMed ID: 34380664

Doi: 10.4049/immunohorizons.2100024

Products & Services: Peptide Synthesis

CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope

Authors: Sarah A Greaves, Avinash Ravindran, Radleigh G Santos, Lan Chen, Michael T Falta, Yang Wang, Angela M Mitchell, Shaikh M Atif, Douglas G Mack, Alex N Tinega, Lisa A Maier, Shaodong Dai, Clemencia Pinilla, Johan Grunewald, Andrew P Fontenot

Journal: J Exp Med

PubMed ID: 34410304

Doi: 10.1084/jem.20210785

Products & Services: Peptide Library Services

Evolutionary and functional relationships in the ribosome biogenesis SBDS and EFL1 protein families

Authors: Alfonso Méndez-Godoy, Daniel García-Montalvo, León P Martínez-Castilla, Nuria Sánchez-Puig

Journal: Mol Genet Genomics

PubMed ID: 34453201

Doi: 10.1007/s00438-021-01814-w

Products & Services: PCR Cloning and Subcloning

New insights into the acetate uptake transporter (AceTr) family: Unveiling amino acid residues critical for specificity and activity

Authors: Toni Rendulić, João Alves, João Azevedo-Silva, Isabel Soares-Silva, Margarida Casal

Journal: Comput Struct Biotechnol J

PubMed ID: 34471488

Doi: 10.1016/j.csbj.2021.08.002

Products & Services: ORF cDNA Clones/MolecularCloud

Double-Stranded RNA-Degrading Enzymes Reduce the Efficiency of RNA Interference in

Authors: Jin-Zhi Chen, Ying-Xia Jiang, Miao-Wen Li, Jian-Wen Li, Ben-Hu Zha, Guang Yang

Journal: Insects

PubMed ID: 34442278

Doi: 10.3390/insects12080712

Products & Services: Monoclonal Antibody Services

Dynamic Changes in the Levels of Amyloid-β Species in the Brain and Periphery of APP/PS1 Mice and Their Significance for Alzheimer's Disease

Authors: Liding Zhang, Changwen Yang, Yanqing Li, Shiqi Niu, Xiaohan Liang, Zhihong Zhang, Qingming Luo, Haiming Luo

Journal: Front Mol Neurosci

PubMed ID: 34512259

Doi: 10.3389/fnmol.2021.723317

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Compound heterozygosis in AADC deficiency: A complex phenotype dissected through comparison among heterodimeric and homodimeric AADC proteins

Authors: Carmen Longo, Riccardo Montioli, Giovanni Bisello, Luana Palazzi, Mario Mastrangelo, Heiko Brennenstuhl, Patrizia Polverino de Laureto, Thomas Opladen, Vincenzo Leuzzi, Mariarita Bertoldi

Journal: Mol Genet Metab

PubMed ID: 34479793

Doi: 10.1016/j.ymgme.2021.08.011

Products & Services: Monoclonal Antibody Services

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