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TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9

Authors: Jinming Zhao, Yan Xiu, Lin Fu, Qianze Dong, Nicholas Borcherding, Yang Wang, Qingchang Li, Nilushi S De Silva, Ulf Klein, Brendan F Boyce, Chen Zhao

Journal: iScience

PubMed ID: 34877491

Doi: 10.1016/j.isci.2021.103425

Products & Services: PCR Cloning and Subcloning

A nanocompartment system contributes to defense against oxidative stress in

Authors: Katie A Lien, Kayla Dinshaw, Robert J Nichols, Caleb Cassidy-Amstutz, Matthew Knight, Rahul Singh, Lindsay D Eltis, David F Savage, Sarah A Stanley

Journal: Elife

PubMed ID: 34751132

Doi: 10.7554/eLife.74358

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Immune reactivity and host modulatory roles of two novel Haemonchus contortus cathepsin B-like proteases

Authors: Mariam Bakshi, Wenbin Tuo, Raffi V Aroian, Dante Zarlenga

Journal: Parasit Vectors

PubMed ID: 34798906

Doi: 10.1186/s13071-021-05010-y

Products & Services: Protein and Antibody Isolation

Gain of Spontaneous Mutations Boosting Motility Adaption to Environments in

Authors: Bingyu Li, Chaofan Hou, Xian Ju, Yong Feng, Zhi-Qiang Ye, Yunzhu Xiao, Mingyao Gu, Chunxiang Fu, Chaoliang Wei, Conghui You

Journal: Front Bioeng Biotechnol

PubMed ID: 34900963

Doi: 10.3389/fbioe.2021.772397

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Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells by inhibiting long noncoding RNA FOXD2-As1-promoted EZH2 activation

Authors: Xuyang Lv, Jiangchuan Sun, Linfeng Hu, Ying Qian, Chunlei Fan, Nan Tian

Journal: Aging (Albany NY)

PubMed ID: 34739394

Doi: 10.18632/aging.203662

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Nogo receptor impairs the clearance of fibril amyloid-β by microglia and accelerates Alzheimer's-like disease progression

Authors: Jianing Wang, Xiaoying Qin, Hao Sun, Meijun He, Qunyu Lv, Congcong Gao, Xinran He, Hong Liao

Journal: Aging Cell

PubMed ID: 34821024

Doi: 10.1111/acel.13515

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Spike residue 403 affects binding of coronavirus spikes to human ACE2

Authors: Fabian Zech, Daniel Schniertshauer, Christoph Jung, Alexandra Herrmann, Arne Cordsmeier, Qinya Xie, Rayhane Nchioua, Caterina Prelli Bozzo, Meta Volcic, Lennart Koepke, Janis A Müller, Jana Krüger, Sandra Heller, Steffen Stenger, Markus Hoffmann, Stefan Pöhlmann, Alexander Kleger, Timo Jacob, Karl-Klaus Conzelmann, Armin Ensser, Konstantin M J Sparrer, Frank Kirchhoff

Journal: Nat Commun

PubMed ID: 34824253

Doi: 10.1038/s41467-021-27180-0

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G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators

Authors: Malarvizhi Gurusamy, Denise Tischner, Jingchen Shao, Stephan Klatt, Sven Zukunft, Remy Bonnavion, Stefan Günther, Kai Siebenbrodt, Roxane-Isabelle Kestner, Tanja Kuhlmann, Ingrid Fleming, Stefan Offermanns, Nina Wettschureck

Journal: Nat Commun

PubMed ID: 34815397

Doi: 10.1038/s41467-021-26882-9

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Plant LHC-like proteins show robust folding and static non-photochemical quenching

Authors: Petra Skotnicová, Hristina Staleva-Musto, Valentyna Kuznetsova, David Bína, Minna M Konert, Shan Lu, Tomáš Polívka, Roman Sobotka

Journal: Nat Commun

PubMed ID: 34824207

Doi: 10.1038/s41467-021-27155-1

Products & Services: Gene Synthesis

Piwi4 Structural Features Are Necessary for RNA Binding and Nuclear Localization

Authors: Adeline E Williams, Gaurav Shrivastava, Apostolos G Gittis, Sundar Ganesan, Ines Martin-Martin, Paola Carolina Valenzuela Leon, Ken E Olson, Eric Calvo

Journal: Int J Mol Sci

PubMed ID: 34884537

Doi: 10.3390/ijms222312733

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SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II

Authors: Richard King, Zesen Lin, Ginette Balbin-Cuesta, Gregg Myers, Ann Friedman, Guojing Zhu, Beth McGee, Thomas L Saunders, Ryo Kurita, Yukio Nakamura, James Douglas Engel, Pavan Reddy, Rami Khoriaty

Journal: Sci Adv

PubMed ID: 34818036

Doi: 10.1126/sciadv.abj5293

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Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells

Authors: Ana Stojiljković, Véronique Gaschen, Franck Forterre, Ulrich Rytz, Michael H Stoffel, Jasmin Bluteau

Journal: Geroscience

PubMed ID: 34806133

Doi: 10.1007/s11357-021-00488-x

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Comprehensive Comparative Analysis of the GATA Transcription Factors in Four Rosaceae Species and Phytohormonal Response in Chinese Pear () Fruit

Authors: Muhammad Aamir Manzoor, Irfan Ali Sabir, Iftikhar Hussain Shah, Han Wang, Zhao Yu, Faiz Rasool, Muhammad Zaid Mazhar, Shoaib Younas, Muhammad Abdullah, Yongping Cai

Journal: Int J Mol Sci

PubMed ID: 34830372

Doi: 10.3390/ijms222212492

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Hsa_circRNA_103124 Upregulation in Crohn's Disease Promotes Cell Proliferation and Inhibits Autophagy by Regulating the Hsa-miR-650/AKT2 Signaling Pathway

Authors: Juan Yin, Fuyi Tong, Yulan Ye, Tong Hu, Lijuan Xu, Liping Zhang, Jianyun Zhu, Zhi Pang

Journal: Front Genet

PubMed ID: 34804121

Doi: 10.3389/fgene.2021.753161

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An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function

Authors: Yuanyong Huang, Xiaoya Duan, Zhen Wang, Yimei Sun, Qingqing Guan, Li Kang, Qiao Zhang, Lan Fang, Jiwen Li, Jiemin Wong

Journal: J Biol Chem

PubMed ID: 34762910

Doi: 10.1016/j.jbc.2021.101389

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His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation

Authors: Gabrielle Parkinson, Peristera Roboti, Ling Zhang, Sandra Taylor, Philip Woodman

Journal: J Cell Sci

PubMed ID: 34657963

Doi: 10.1242/jcs.259192

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Insulin-like growth factor 2 mRNA binding protein 2 regulates proliferation, migration and angiogenesis of keratinocytes by modulating heparanase stability

Authors: Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang, Guoxiang Fang

Journal: Bioengineered

PubMed ID: 34753397

Doi: 10.1080/21655979.2021.2002495

Products & Services: ORF cDNA Clones/MolecularCloud

Serine palmitoyltransferase assembles at ER-mitochondria contact sites

Authors: Mari J Aaltonen, Irina Alecu, Tim König, Steffany Al Bennett, Eric A Shoubridge

Journal: Life Sci Alliance

PubMed ID: 34785538

Doi: 10.26508/lsa.202101278

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Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes

Authors: Pim J Huis In 't Veld, Sabine Wohlgemuth, Carolin Koerner, Franziska Müller, Petra Janning, Andrea Musacchio

Journal: Protein Sci

PubMed ID: 34791727

Doi: 10.1002/pro.4233

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SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets

Authors: Syam Prakash Somasekharan, Martin Gleave

Journal: FEBS Lett

PubMed ID: 34780058

Doi: 10.1002/1873-3468.14229

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Antiseptic 9-Meric Peptide with Potency against Carbapenem-Resistant Infection

Authors: Manigandan Krishnan, Joonhyeok Choi, Ahjin Jang, Young Kyung Yoon, Yangmee Kim

Journal: Int J Mol Sci

PubMed ID: 34830401

Doi: 10.3390/ijms222212520

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Breadth of CD8 T-cell mediated inhibition of replication of diverse HIV-1 transmitted-founder isolates correlates with the breadth of recognition within a comprehensive HIV-1 Gag, Nef, Env and Pol potential T-cell epitope (PTE) peptide set

Authors: Peter Hayes, Natalia Fernandez, Christina Ochsenbauer, Jama Dalel, Jonathan Hare, Deborah King, Lucas Black, Claire Streatfield, Vanaja Kakarla, Gladys Macharia, Julia Makinde, Matt Price, Eric Hunter, Jill Gilmour

Journal: PLoS ONE

PubMed ID: 34788349

Doi: 10.1371/journal.pone.0260118

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PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates

Authors: Nobuyuki Shimizu, Tomoko Asatsuma-Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito

Journal: Commun Biol

PubMed ID: 34764413

Doi: 10.1038/s42003-021-02801-y

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Long noncoding RNA SNHG25 promotes the malignancy of endometrial cancer by sponging microRNA-497-5p and increasing FASN expression

Authors: Yuhua He, Shuifang Xu, Yi Qi, Jinfang Tian, Fengying Xu

Journal: J Ovarian Res

PubMed ID: 34789312

Doi: 10.1186/s13048-021-00906-w

Products & Services: Plasmid DNA Preparation

Comparison of Antibody Response Elicited by ChAdOx1 and BNT162b2 COVID-19 Vaccine

Authors: Yu Min Kang, Dohsik Minn, Jaegyun Lim, Ki-Deok Lee, Dong Ho Jo, Kang-Won Choe, Moon Jung Kim, Jong Min Kim, Kwang Nam Kim

Journal: J Korean Med Sci

PubMed ID: 34845875

Doi: 10.3346/jkms.2021.36.e311

Development of surface engineered antigenic exosomes as vaccines for respiratory syncytial virus

Authors: Suyeon Hong, Shaobo Ruan, Zachary Greenberg, Mei He, Jodi L McGill

Journal: Sci Rep

PubMed ID: 34725399

Doi: 10.1038/s41598-021-00765-x

Products & Services: Peptide Synthesis

CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation

Authors: Lorna M Stewart, Lisa Gerner, Mandy Rettel, Frank Stein, James F Burrows, Ian G Mills, Emma Evergren

Journal: Cell Death Dis

PubMed ID: 34725334

Doi: 10.1038/s41419-021-04335-x

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Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea

Authors: Yu Kyung Kim, Dohsik Minn, Do Young Song, Chae Hoon Lee, Nam Hee Ryoo, Chang-Ho Jeon, Kyung Eun Song, Jang Soo Suh, Soon Hee Chang

Journal: J Korean Med Sci

PubMed ID: 34751011

Doi: 10.3346/jkms.2021.36.e294

AZD3759 enhances radiation effects in non-small-cell lung cancer by a synergistic blockade of epidermal growth factor receptor and Janus kinase-1

Authors: Ruing Zhao, Wei Yin, Qingqing Yu, Yanjiao Mao, Qinghua Deng, Ke Zhang, Shenglin Ma

Journal: Bioengineered

PubMed ID: 34738874

Doi: 10.1080/21655979.2021.2001238

Products & Services: Gene Synthesis

Backbone H, N, and C resonance assignments of the non-structural protein NS2B of Zika virus

Authors: Beatriz Rosa Penna, Danielle Maria P de Oliveira, Cristiane Dinis Anobom, Ana Paula Valente

Journal: Biomol NMR Assign

PubMed ID: 34817802

Doi: 10.1007/s12104-021-10055-2

Products & Services: Codon Optimization

Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas

Authors: Jill P Smith, Hong Cao, Elijah F Edmondson, Siva Sai Krishna Dasa, Stephan T Stern

Journal: Biomolecules

PubMed ID: 34944412

Doi: 10.3390/biom11121766

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JNK/Itch Axis Mediates the Lipopolysaccharide-Induced Ubiquitin-Proteasome-Dependent Degradation of Ferritin Light Chain in Murine Macrophage Cells

Authors: Shufen He, Jianqi Xue, Pengxiu Cao, Jianyuan Hou, Yan Cui, Jing Chang, Liying Huang, Yu Han, Xianglin Duan, Ke Tan, Yumei Fan

Journal: Inflammation

PubMed ID: 34837126

Doi: 10.1007/s10753-021-01603-y

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Limited Impact of Delta Variant's Mutations on the Effectiveness of Neutralization Conferred by Natural Infection or COVID-19 Vaccines in a Latino Population

Authors: Carlos A Sariol, Crisanta Serrano-Collazo, Edwin J Ortiz, Petraleigh Pantoja, Lorna Cruz, Teresa Arana, Dianne Atehortua, Christina Pabon-Carrero, Ana M Espino

Journal: Viruses

PubMed ID: 34960674

Doi: 10.3390/v13122405

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Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages

Authors: Christian Kretzer, Paul M Jordan, Katharina P L Meyer, Daniel Hoff, Markus Werner, Robert Klaus Hofstetter, Andreas Koeberle, Antonio Cala Peralta, Guillaume Viault, Denis Seraphin, Pascal Richomme, Jean-Jacques Helesbeux, Hermann Stuppner, Veronika Temml, Daniela Schuster, Oliver Werz

Journal: Biochem Pharmacol

PubMed ID: 34762841

Doi: 10.1016/j.bcp.2021.114825

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Endotoxin contamination in commercially available Cas9 proteins potentially induces T-cell mediated responses

Authors: Vijaya L Simhadri, Joseph R McGill, Zuben E Sauna

Journal: Gene Ther

PubMed ID: 34744169

Doi: 10.1038/s41434-021-00301-6

Products & Services: Protein and Antibody Isolation

Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes

Authors: Novalia Pishesha, Thibault Harmand, Liyan Y Smeding, Weiyi Ma, Leif S Ludwig, Robine Janssen, Ashraful Islam, Yushu J Xie, Tao Fang, Nicholas McCaul, William Pinney, Harun R Sugito, Martin A Rossotti, Gualberto Gonzalez-Sapienza, Hidde L Ploegh

Journal: Nature biomedical engineering

PubMed ID: 34127819

Doi: doi.org/10.1038/s41551-021-00738-5

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Critical cysteines in the functional interaction of adenylyl cyclase isoform 6 with Gαs

Authors: Anjali Y Bhagirath, Vikram Bhatia, Manoj Reddy Medapati, Nisha Singh, Martha Hinton, Prashen Chelikani, Shyamala Dakshinamurti

Journal: FASEB Bioadv

PubMed ID: 35664968

Doi: 10.1096/fba.2021-00073

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Fasudil prevents neomycin-induced hair cell damage by inhibiting autophagy through the miR-489/NDP52 signaling pathway in HEI-OC1 cells

Authors: Wei Li, Yanqiu Zhang, Jifeng Xu, Jincan Chen, Xia Gao

Journal: Exp Ther Med

PubMed ID: 34849158

Doi: 10.3892/etm.2021.10965

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Vectored antibody gene delivery restores host B and T cell control of persistent viral infection

Authors: Yusuf I Ertuna, Benedict Fallet, Anna-Friederike Marx, Mirela Dimitrova, Anna Lena Kastner, Ingrid Wagner, Doron Merkler, Daniel D Pinschewer

Journal: Cell Rep

PubMed ID: 34852228

Doi: 10.1016/j.celrep.2021.110061

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Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD/SIRT6 axis

Authors: Christopher A Koczor, Kate M Saville, Joel F Andrews, Jennifer Clark, Qingming Fang, Jianfeng Li, Rasha Q Al-Rahahleh, Md Ibrahim, Steven McClellan, Mikhail V Makarov, Marie E Migaud, Robert W Sobol

Journal: Cell Rep

PubMed ID: 34731617

Doi: 10.1016/j.celrep.2021.109917

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Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells

Authors: Ria Goswami, Veronica S Russell, Joshua J Tu, Charlene Thomas, Philip Hughes, Francine Kelly, Stephanie N Langel, Justin Steppe, Scott M Palmer, Timothy Haystead, Maria Blasi, Sallie R Permar

Journal: iScience

PubMed ID: 34786537

Doi: 10.1016/j.isci.2021.103412

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Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

Authors: Hsiang-Chi Huang, Yun-Ju Lai, Chun-Che Liao, Wang-Feng Yang, Ke-Bin Huang, I-Jung Lee, Wen-Cheng Chou, Shih-Han Wang, Ling-Hui Wang, Jung-Mao Hsu, Cheng-Pu Sun, Chun-Tse Kuo, Jyun Wang, Tzu-Chun Hsiao, Po-Jiun Yang, Te-An Lee, Wilson Huang, Fu-An Li, Chen-Yang Shen, Yi-Ling Lin, Mi-Hua Tao, Chia-Wei Li

Journal: EBioMedicine

PubMed ID: 34839261

Doi: 10.1016/j.ebiom.2021.103712

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An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination

Authors: Dengning Xia, Rui Jin, Gaurav Byagathvalli, Huan Yu, Ling Ye, Chao-Yi Lu, M Saad Bhamla, Chinglai Yang, Mark R Prausnitz

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34670842

Doi: 10.1073/pnas.2110817118

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VviPLATZ1 is a major factor that controls female flower morphology determination in grapevine

Authors: Pat Iocco-Corena, Jamila Chaïb, Laurent Torregrosa, Don Mackenzie, Mark R Thomas, Harley M Smith

Journal: Nat Commun

PubMed ID: 34848714

Doi: 10.1038/s41467-021-27259-8

Lipid-Binding Aegerolysin from Biocontrol Fungus

Authors: Nada Kraševec, Anastasija Panevska, Špela Lemež, Jaka Razinger, Kristina Sepčić, Gregor Anderluh, Marjetka Podobnik

Journal: Toxins (Basel)

PubMed ID: 34822604

Doi: 10.3390/toxins13110820

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Rapid Response to SARS-CoV-2 in Aotearoa New Zealand: Implementation of a Diagnostic Test and Characterization of the First COVID-19 Cases in the South Island

Authors: Blair Lawley, Jenny Grant, Rhodri Harfoot, Jackson M Treece, Robert Day, Leonor C Hernández, Jo-Ann L Stanton, James E Ussher, Miguel E Quiñones-Mateu

Journal: Viruses

PubMed ID: 34835031

Doi: 10.3390/v13112222

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Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival

Authors: Fiamma Berner, Rebekka Niederer, Jolien J Luimstra, Oltin Tiberiu Pop, Ann-Kristin Jochum, Mette-Triin Purde, Omar Hasan Ali, David Bomze, Jens Bauer, Lena Katharina Freudenmann, Ana Marcu, Eva-Maria Wolfschmitt, Sebastian Haen, Thorben Gross, Marissa Lisa Dubbelaar, Marie-Therese Abdou, Petra Baumgaertner, Christina Appenzeller, Caroline Cicin-Sain, Tobias Lenz, Daniel E Speiser, Burkhard Ludewig, Christoph Driessen, Markus Jörger, Martin Früh, Wolfram Jochum, Antonio Cozzio, Hans-Georg Rammensee, Juliane Walz, Jacques Neefjes, Lukas Flatz

Journal: Oncoimmunology

PubMed ID: 34858733

Doi: 10.1080/2162402X.2021.2006893

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Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

Authors: Elwood A Mullins, Jonathan Dorival, Gong-Li Tang, Dale L Boger, Brandt F Eichman

Journal: Nat Commun

PubMed ID: 34836957

Doi: 10.1038/s41467-021-27284-7

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MUC1 ectodomain is a flagellin-targeting decoy receptor and biomarker operative during Pseudomonas aeruginosa lung infection

Authors: Avelino C Verceles, Pavan Bhat, Zain Nagaria, Destiny Martin, Harsh Patel, Afua Ntem-Mensah, Sang W Hyun, Andrea Hahn, Jean Jeudy, Alan S Cross, Erik P Lillehoj, Simeon E Goldblum

Journal: Sci Rep

PubMed ID: 34811449

Doi: 10.1038/s41598-021-02242-x

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Development and Characterization of Magnetic SARS-CoV-2 Peptide-Imprinted Polymers

Authors: Beatriz Fresco-Cala, Soumya Rajpal, Tamara Rudolf, Benedikt Keitel, Rüdiger Groß, Jan Münch, Alex D Batista, Boris Mizaikoff

Journal: Nanomaterials (Basel)

PubMed ID: 34835749

Doi: 10.3390/nano11112985

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