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至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

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JA signal-mediated immunity of Dendrobium catenatum to necrotrophic Southern Blight pathogen

Authors: Cong Li, Qiuyi Shen, Xiang Cai, Danni Lai, Lingshang Wu, Zhigang Han, Tianlun Zhao, Donghong Chen, Jinping Si

Journal: BMC Plant Biol

PubMed ID: 34362300

Doi: 10.1186/s12870-021-03134-y

Products & Services: Protein Tools

A Split-Cre system designed to detect simultaneous expression of two genes based on SpyTag/SpyCatcher conjugation and Split-GFP dimerization

Authors: Xundong Wei, Jianhua Zhang, Jian Cui, Wei Xu, Xuyu Zhou, Jie Ma

Journal: J Biol Chem

PubMed ID: 34450162

Doi: 10.1016/j.jbc.2021.101119

Products & Services: Custom Vector Construction

Phosphorylation of Androgen Receptor by mTORC1 Promotes Liver Steatosis and Tumorigenesis

Authors: Qian-Nan Ren, Hong Zhang, Chao-Yue Sun, Yu-Feng Zhou, Xue-Feng Yang, Jian-Wu Long, Xiao-Xing Li, Shi-Juan Mai, Mei-Yin Zhang, Hui-Zhong Zhang, Hai-Qiang Mai, Min-Shan Chen, X F Steven Zheng, Hui-Yun Wang

Journal: Hepatology

PubMed ID: 34435708

Doi: 10.1002/hep.32120

Products & Services: Catalog Peptides

Pyrophosphate release acts as a kinetic checkpoint during high-fidelity DNA replication by the Staphylococcus aureus replicative polymerase PolC

Authors: Sean P Fagan, Purba Mukherjee, William J Jaremko, Rachel Nelson-Rigg, Ryan C Wilson, Tyler L Dangerfield, Kenneth A Johnson, Indrajit Lahiri, Janice D Pata

Journal: Nucleic Acids Res

PubMed ID: 34302475

Doi: 10.1093/nar/gkab613

Products & Services: Bacterial Expression

Expression of heat-resistant β-glucosidase in and its application in the production of gardenia blue

Authors: Wenxi Li, Jielin Li, Ying Xu, Yan Huang, Shuqi Xu, Zirui Ou, Xiaoli Long, Xinyu Li, Xinyu Liu, Zening Xiao, Jiaqi Huang, Weizhao Chen

Journal: Synth Syst Biotechnol

PubMed ID: 34504963

Doi: 10.1016/j.synbio.2021.08.002

Products & Services: ORF cDNA Clones/MolecularCloud

SARS-CoV-2 neutralizing antibodies after first vaccination dose in breast cancer patients receiving CDK4/6 inhibitors

Authors: Flora Zagouri, Evangelos Terpos, Oraianthi Fiste, Michalis Liontos, Alexandros Briasoulis, Ioanna Katsiana, Efi Skafida, Christos Markellos, Elena Kunadis, Angeliki Andrikopoulou, Maria Kaparelou, Konstantinos Koutsoukos, Maria Gavriatopoulou, Efstathios Kastritis, Ioannis P Trougakos, Meletios-Athanasios Dimopoulos

Journal: Breast

PubMed ID: 34481366

Doi: 10.1016/j.breast.2021.08.017

Products & Services: PCR and Cloning

Profiling CD8 T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants

Authors: Hang Zhang, Shasha Deng, Liting Ren, Peiyi Zheng, Xiaowen Hu, Tengchuan Jin, Xu Tan

Journal: Cell Rep

PubMed ID: 34506741

Doi: 10.1016/j.celrep.2021.109708

Products & Services: Peptide Synthesis

The neutralizing antibody response post COVID-19 vaccination in patients with myeloma is highly dependent on the type of anti-myeloma treatment

Authors: Evangelos Terpos, Maria Gavriatopoulou, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Panagiotis Malandrakis, Despina Fotiou, Eleni-Dimitra Papanagnou, Magdalini Migkou, Foteini Theodorakakou, Maria Roussou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Ioannis P Trougakos, Efstathios Kastritis, Meletios A Dimopoulos

Journal: Blood Cancer J

PubMed ID: 34341335

Doi: 10.1038/s41408-021-00530-3

7-Ethoxyrosmanol alleviates hyperglycemia-induced vascular endothelial dysfunction by regulating FBXL7 expression

Authors: Jianqi Ni, Lan Shen, Liu Xu, Qin Jin, Guoliang Wang

Journal: J Bioenerg Biomembr

PubMed ID: 34427826

Doi: 10.1007/s10863-021-09916-1

Products & Services: Plasmid DNA Preparation

SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters

Authors: Julia R Port, Claude Kwe Yinda, Irene Offei Owusu, Myndi Holbrook, Robert Fischer, Trenton Bushmaker, Victoria A Avanzato, Jonathan E Schulz, Craig Martens, Neeltje van Doremalen, Chad S Clancy, Vincent J Munster

Journal: Nat Commun

PubMed ID: 34404778

Doi: 10.1038/s41467-021-25156-8

Products & Services: Custom Vector Construction

miR-33a-5p inhibits the progression of esophageal cancer through the DKK1-mediated Wnt/β-catenin pathway

Authors: Qingping Song, Hui Liu, Chengyan Li, Haifeng Liang

Journal: Aging (Albany NY)

PubMed ID: 34426559

Doi: 10.18632/aging.203430

Products & Services: Custom DNA/RNA Oligos

Insertion of prpoD_rpoS fragment enhances expression of recombinant protein by dps auto-inducible promoter in Escherichia coli

Authors: Dina Mulyanti, Sundani Nurono Soewandhi, Catur Riani

Journal: Mol Biol Rep

PubMed ID: 34342815

Doi: 10.1007/s11033-021-06562-z

Products & Services: Plasmid DNA Preparation

Genome Editing in Zebrafish by ScCas9 Recognizing NNG PAM

Authors: Yunxing Liu , Fang Liang , Zijiong Dong , Song Li , Jianmin Ye and Wei Qin

Journal: Cells

PubMed ID: 34440868

Doi: 10.3390/cells10082099

Products & Services: Gene Services

Subtype-selective positive modulation of K Ca 2 channels depends on the HA/HB helices

Authors: Young-Woo Nam，Meng Cui， Naglaa Salem，Razan Orfali，Misa Nguyen， Grace Yang，Mohammad Asikur Rahman， Judy Lee，Miao Zhang

Journal: British Journal of Pharmacol

PubMed ID: 34458981

Doi: 10.1111/bph.15676

Products & Services: Gene Synthesis

Comparability of six different immunoassays measuring SARS-CoV-2 antibodies with neutralizing antibody levels in convalescent plasma: From utility to prediction

Authors: Abigail Lamikanra, Dung Nguyen, Peter Simmonds, Sarah Williams, Emma M Bentley, Cathy Rowe, Ashley David Otter, Tim Brooks, Kimberly Gilmour, Annabelle Mai, Jusvinder Dadhra, Mabel Csatari, Sheba Ziyenge, Marta Oliveira, Rutger Ploeg, Pat Tsang, Maria Zambon, Robin Gopal, Julie Huiyuan Xiao, Alain Townsend, David Roberts, Heli Harvala

Journal: Transfusion

PubMed ID: 34342366

Doi: 10.1111/trf.16600

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

Light-Induced Dynamic Change of Phytochrome B and Cryptochrome 1 Stabilizes SINATs in

Authors: Jin Hu, Yinmeng Hu, Mengran Yang, Xiaotong Hu, Xuelu Wang

Journal: Front Plant Sci

PubMed ID: 34490020

Doi: 10.3389/fpls.2021.722733

Products & Services: Proteins, Expression, Isolation and Analysis

The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis

Authors: Amanda J Morris, Lindsay Jackson, Yvonne Cw Yau, Courtney Reichhardt, Trevor Beaudoin, Stephanie Uwumarenogie, Kevin M Guttman, P Lynne Howell, Matthew R Parsek, Lucas R Hoffman, Dao Nguyen, Antonio DiGiandomenico, David S Guttman, Daniel J Wozniak, Valerie J Waters

Journal: NPJ Biofilms Microbiomes

PubMed ID: 34349133

Doi: 10.1038/s41522-021-00234-3

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinase polymerase amplification (RPA) with lateral flow detection for three Anaplasma species of importance to livestock health

Authors: Andrea Salazar, Francisco M Ochoa-Corona, Justin L Talley, Bruce H Noden

Journal: Sci Rep

PubMed ID: 34354122

Doi: 10.1038/s41598-021-95402-y

Products & Services: Proteins, Expression, Isolation and Analysis

CD27 expression on Treg cells limits immune responses against tumors

Authors: Sabine Muth, Annekatrin Klaric, Markus Radsak, Hansjörg Schild, Hans Christian Probst

Journal: J Mol Med (Berl)

PubMed ID: 34423375

Doi: 10.1007/s00109-021-02116-9

Products & Services: Protein Tools

A Novel microRNA of Japanese Flounder Regulates Antimicrobial Immunity Involving a Bacteria-Binding CSF3

Authors: Wenrui Li, Xiaolu Guan, Bin Sun, Li Sun

Journal: Front Immunol

PubMed ID: 34489973

Doi: 10.3389/fimmu.2021.723401

Products & Services: Plasmid DNA Preparation

Molecular architecture and modifications of full-length myocilin

Authors: Mackenzie D Martin, Dustin J E Huard, Ricardo C Guerrero-Ferreira, Ishani M Desai, Brett M Barlow, Raquel L Lieberman

Journal: Exp Eye Res

PubMed ID: 34400147

Doi: 10.1016/j.exer.2021.108729

Products & Services: Plasmid DNA Preparation

Screening for androgen agonists using autonomously bioluminescent HEK293 reporter cells

Authors: Tingting Xu, Madison Gilliam, Gary Sayler, Steven Ripp, Dan Close

Journal: BioTechniques

PubMed ID: 34350768

Doi: 10.2144/btn-2021-0017

Products & Services: Plasmid DNA Preparation

TREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis

Authors: Lijing Wang, Qiong Chen, Qiao Yu, Jian Xiao, Hongjun Zhao

Journal: Inflamm Res

PubMed ID: 34374795

Doi: 10.1007/s00011-021-01490-x

Products & Services: Peptide Synthesis

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies

Authors: Ethan W Hass, Zachary A Sorrentino, Yuxing Xia, Grace M Lloyd, John Q Trojanowski, Stefan Prokop, Benoit I Giasson

Journal: Acta Neuropathol Commun

PubMed ID: 34454615

Doi: 10.1186/s40478-021-01242-2

Products & Services: Peptide Synthesis

Heterologous Complementation of SPO11-1 and -2 Depends on the Splicing Pattern

Authors: Thorben Sprink, Frank Hartung

Journal: Int J Mol Sci

PubMed ID: 34502253

Doi: 10.3390/ijms22179346

Products & Services: Peptide Synthesis

Porcine Epidemic Diarrhea Virus Inhibits HDAC1 Expression To Facilitate Its Replication via Binding of Its Nucleocapsid Protein to Host Transcription Factor Sp1

Authors: Jidong Xu, Junyong Mao, Xiao Han, Fushan Shi, Qin Gao, Tingjun Wang, Zhenning Zhang, Ying Shan, Weihuan Fang, Xiaoliang Li

Journal: J Virol

PubMed ID: 34232065

Doi: 10.1128/JVI.00853-21

Products & Services: PCR Cloning and Subcloning

Sex Differences in the Hypothalamic Oxytocin Pathway to Locus Coeruleus and Augmented Attention with Chemogenetic Activation of Hypothalamic Oxytocin Neurons

Authors: Xin Wang, Joan B Escobar, David Mendelowitz

Journal: Int J Mol Sci

PubMed ID: 34445224

Doi: 10.3390/ijms22168510

Products & Services: PCR Cloning and Subcloning

Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function Studies

Authors: Hai Trong Nguyen, Darryl Falzarano, Volker Gerdts, Qiang Liu

Journal: J Virol

PubMed ID: 34191580

Doi: 10.1128/JVI.00687-21

Products & Services: PCR Cloning and Subcloning

Construction and preservation of a stable and highly expressed recombinant Helicobacter pylori vacuolating cytotoxin A with apoptotic activity

Authors: Ling-Zhi Yuan, Xiao Shi, Dan Tang, Shao-Peng Zheng, Zhi-Ming Xiao, Fen Wang

Journal: BMC Microbiol

PubMed ID: 34407768

Doi: 10.1186/s12866-021-02262-7

Products & Services: Nucleic Acid Purification & Analysis

MiR-199b-5p Promotes Gastric Cancer Progression by Regulating HHIP Expression

Authors: Songda Chen, Huijie Wu, Lingyu Zhu, Mengjie Jiang, Shuli Wei, Jinhua Luo, Aiqun Liu

Journal: Front Oncol

PubMed ID: 34532291

Doi: 10.3389/fonc.2021.728393

Products & Services: Mutant Libraries

Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models

Authors: Anja Schulze-Krebs, Fabio Canneva, Judith Stemick, Anne-Christine Plank, Julia Harrer, Gillian P Bates, Daniel Aeschlimann, Joan S Steffan, Stephan von Hörsten

Journal: Int J Mol Sci

PubMed ID: 34445621

Doi: 10.3390/ijms22168914

Products & Services: Mutant Libraries

Mechanism of Anti-Inflammatory Activity of TLR4-Interacting SPA4 Peptide

Authors: Shanjana Awasthi, Gaurav Kumar, Vijay Ramani, Vibhudutta Awasthi, Karla K Rodgers, Jun Xie, Jacob Beierle, Gertrude Kyere-Davies, Bhupinder Singh, Negar Rahman, Asif Alam Chowdhury, Neha Chataut

Journal: Immunohorizons

PubMed ID: 34429343

Doi: 10.4049/immunohorizons.2100067

Products & Services: Mutant Libraries

Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction

Authors: Armando Estrada, Alejandro C Rodriguez, Georgialina Rodriguez, Alice H Grant, Yoshira M Ayala-Marin, Amy J Arrieta, Robert A Kirken

Journal: Sci Rep

PubMed ID: 34417497

Doi: 10.1038/s41598-021-96428-y

Products & Services: Mammalian Expression

Circular RNA FNDC3B Protects Oral Squamous Cell Carcinoma Cells From Ferroptosis and Contributes to the Malignant Progression by Regulating miR-520d-5p/SLC7A11 Axis

Authors: Jie Yang, Xing-Hua Cao, Ke-Feng Luan, Yun-Dong Huang

Journal: Front Oncol

PubMed ID: 34434890

Doi: 10.3389/fonc.2021.672724

Products & Services: Mammalian Expression

A Widespread Bacterial Secretion System with Diverse Substrates

Authors: Alex S Grossman, Terra J Mauer, Katrina T Forest, Heidi Goodrich-Blair

Journal: MBio.

PubMed ID: 34399622

Doi: 10.1128/mBio.01956-21

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor

Authors: Kim Ghilarducci, Valérie C Cabana, Camille Desroches, Kahina Chabi, Steve Bourgault, Laurent Cappadocia, Marc P Lussier

Journal: FEBS J

PubMed ID: 33650289

Doi: 10.1111/febs.15796

Products & Services: Gene Synthesis

Live-cell imaging of microRNA expression with post-transcriptional feedback control

Authors: Masayuki Sano, Kana Morishita, Satoshi Oikawa, Takayuki Akimoto, Kimio Sumaru, Yoshio Kato

Journal: Mol Ther Nucleic Acids

PubMed ID: 34631284

Doi: 10.1016/j.omtn.2021.08.018

Products & Services: Mammalian Expression

Identification of the Biosynthetic Gene Cluster for the Organoarsenical Antibiotic Arsinothricin

Authors: Adriana E Galván, Ngozi P Paul, Jian Chen, Kunie Yoshinaga-Sakurai, Sagar M Utturkar, Barry P Rosen, Masafumi Yoshinaga

Journal: Microbiol Spectr

PubMed ID: 34378964

Doi: 10.1128/Spectrum.00502-21

Products & Services: Mammalian Expression

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

Authors: Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo, Qiwei Zhang, Jianguo Wu

Journal: Signal Transduct Target Ther

PubMed ID: 34408131

Doi: 10.1038/s41392-021-00726-w

Products & Services: GenParts™ DNA Fragments

Aptamer-Integrated Scaffolds for Biologically Functional DNA Origami Structures

Authors: Xiaoxing Chen, Bin Jia, Zhangwei Lu, Libing Liao, Hanyang Yu, Zhe Li

Journal: ACS Appl Mater Interfaces

PubMed ID: 34402304

Doi: 10.1021/acsami.1c09307

Products & Services: GenParts™ DNA Fragments

Exploring functionality of the reverse β-oxidation pathway in Corynebacterium glutamicum for production of adipic acid

Authors: Jae Ho Shin, Aaron John Christian Andersen, Puck Achterberg, Lisbeth Olsson

Journal: Microb Cell Fact

PubMed ID: 34348702

Doi: 10.1186/s12934-021-01647-7

Products & Services: Gene Synthesis

A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice

Authors: Arshad Khan, Ekramy E Sayedahmed, Vipul K Singh, Abhishek Mishra, Stephanie Dorta-Estremera, Sita Nookala, David H Canaday, Min Chen, Jin Wang, K Jagannadha Sastry, Suresh K Mittal, Chinnaswamy Jagannath

Journal: Cell Rep Med

PubMed ID: 34467249

Doi: 10.1016/j.xcrm.2021.100372

Products & Services: Gene Synthesis

Der f 38 Is a Novel TLR4-Binding Allergen Related to Allergy Pathogenesis from

Authors: Geunyeong Kim, Minhwa Hong, Ayesha Kashif, Yujin Hong, Beom-Seok Park, Ji-Young Mun, Hyosun Choi, Ji-Sook Lee, Eun-Ju Yang, Ran-Sook Woo, Soo-Jin Lee, Minseo Yang, In-Sik Kim

Journal: Int J Mol Sci

PubMed ID: 34445142

Doi: 10.3390/ijms22168440

Products & Services: Endotoxin Detection & Removal System

Decisive Effects of Life Stage on the Gut Microbiota Discrepancy Between Two Wild Populations of Hibernating Asiatic Toads ()

Authors: Xiaowei Song, Jingwei Zhang, Jinghan Song, Yuanyuan Zhai

Journal: Front Microbiol

PubMed ID: 34413833

Doi: 10.3389/fmicb.2021.665849

Products & Services: DNA Sequencing

Functionalizing Cell-Free Systems with CRISPR-Associated Proteins: Application to RNA-Based Circuit Engineering

Authors: François-Xavier Lehr, Alina Kuzembayeva, Megan E Bailey, Werner Kleindienst, Johannes Kabisch, Heinz Koeppl

Journal: ACS Synth Biol

PubMed ID: 34383464

Doi: 10.1021/acssynbio.0c00386

Products & Services: DNA Sequencing

Development of a real-time recombinase-aided amplification (RT-RAA) molecular diagnosis assay for sensitive and rapid detection of Toxoplasma gondii

Authors: Zhao-Hua Wang, Wei Zhang, Xiu-Zhong Zhang, Xin-Ran Yao, Wei Huang, Hong Jia, Xiao-Lei Liu, Shao-Hua Hou, Xiao-Jia Wang

Journal: Vet Parasitol

PubMed ID: 34384956

Doi: 10.1016/j.vetpar.2021.109489

Products & Services: DNA Sequencing

Engineering entropy-driven based multiple signal amplification strategy for visualized assay of miRNA by naked eye

Authors: Sha Zhu, Yi Qi Yang, Yuedi Ding, Ninghan Feng, Menglu Li, Yongmei Yin

Journal: Talanta

PubMed ID: 34517667

Doi: 10.1016/j.talanta.2021.122810

Products & Services: DNA Sequencing

Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non-alcoholic fatty liver disease

Authors: Xiaoyu Qi, Anping Song, Mingyue Ma, Peipei Wang, Xinbei Zhang, Chunfeng Lu, Junxiu Zhang, Shuguo Zheng, Huanhuan Jin

Journal: Cell Prolif

PubMed ID: 34346124

Doi: 10.1111/cpr.13107

Products & Services: DNA Sequencing

MiR-590-5p inhibits pathological hypertrophy mediated heart failure by targeting RTN4

Authors: Ping Fan, Likun Zhang, Tianyu Cheng, Jing Wang, Junyun Zhou, Li Zhao, Cuie Hua, Quan Xia

Journal: J Mol Histol

PubMed ID: 34406553

Doi: 10.1007/s10735-021-10009-x

Products & Services: DNA Sequencing

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

Authors: Yanyun Du, Rui Shi, Ying Zhang, Xiaomin Duan, Li Li, Jing Zhang, Fengze Wang, Ruixue Zhang, Hao Shen, Yue Wang, Zheng Wu, Qianwen Peng, Ting Pan, Wanwei Sun, Weijin Huang, Yue Feng, Hui Feng, Junyu Xiao, Wenjie Tan, Youchun Wang, Chenhui Wang, Jinghua Yan

Journal: Nat Commun

PubMed ID: 34404805

Doi: 10.1038/s41467-021-25331-x

Products & Services: DNA Sequencing

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