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Lysine Residues in the MK-Rich Region Are Not Required for Binding of the PbsP Protein From Group B Streptococci to Plasminogen

Authors: Francesco Coppolino, Letizia Romeo, Giampiero Pietrocola, Germana Lentini, Giuseppe Valerio De Gaetano, Giuseppe Teti, Roberta Galbo, Concetta Beninati

Journal: Front Cell Infect Microbiol

PubMed ID: 34568085

Doi: 10.3389/fcimb.2021.679792

Products & Services: Peptide Synthesis

Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs

Authors: Lifeng Fu, Shuai Shao, Yong Feng, Fei Ye, Xue Sun, Qingling Wang, Feng Yu, Qisheng Wang, Baoying Huang, Peihua Niu, Xuebing Li, Catherine C L Wong, Jianxun Qi, Wenjie Tan, George Fu Gao

Journal: MBio

PubMed ID: 34579576

Doi: 10.1128/mBio.02220-21

Products & Services: Peptide Synthesis

Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

Authors: Taisuke Nakahama, Yuki Kato, Toshiharu Shibuya, Maal Inoue, Jung In Kim, Tuangtong Vongpipatana, Hiroyuki Todo, Yanfang Xing, Yukio Kawahara

Journal: Immunity

PubMed ID: 34525338

Doi: 10.1016/j.immuni.2021.08.022

Products & Services: Stable Cell Lines

Development of a Recombinant RBD Subunit Vaccine for SARS-CoV-2

Authors: Yi-Sheng Sun, Jing-Jing Zhou, Han-Ping Zhu, Fang Xu, Wen-Bin Zhao, Hang-Jing Lu, Zhen Wang, Shu-Qing Chen, Ping-Ping Yao, Jian-Min Jiang, Zhan Zhou

Journal: Viruses

PubMed ID: 34696367

Doi: 10.3390/v13101936

Products & Services: SARS-CoV-2 qRT-PCR Detection Assay

Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice

Authors: Donghui Zhang, Hong Zhu, Enbo Zhan, Fan Wang, Yue Liu, Wei Xu, Xian Liu, Jingjin Liu, Shufeng Li, Yong Pan, Yongshun Wang, Wei Cao

Journal: Front Cell Dev Biol

PubMed ID: 34631690

Doi: 10.3389/fcell.2021.647131

Products & Services: Recombinant Antibody Expression

Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain

Authors: Stefano Suzzi, Reiner Ahrendt, Stefan Hans, Svetlana A Semenova, Avinash Chekuru, Paul Wirsching, Volker Kroehne, Saygın Bilican, Shady Sayed, Sylke Winkler, Sandra Spieß, Anja Machate, Jan Kaslin, Pertti Panula, Michael Brand

Journal: PLoS Genet

PubMed ID: 34516550

Doi: 10.1371/journal.pgen.1009794

Products & Services: Proteins, Expression, Isolation and Analysis

The evidence for and consequences of metabotropic glutamate receptor heterodimerization

Authors: Tyler W McCullock, Paul J Kammermeier

Journal: Neuropharmacology

PubMed ID: 34547332

Doi: 10.1016/j.neuropharm.2021.108801

Products & Services: Proteins, Expression, Isolation and Analysis

Tagging and Capturing of Lentiviral Vectors Using Short RNAs

Authors: Martin Panigaj, Michael P Marino, Jakob Reiser

Journal: Int J Mol Sci

PubMed ID: 34638603

Doi: 10.3390/ijms221910263

Products & Services: Plasmid DNA Preparation

RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates

Authors: Xiaoyan Pan, Jian Shi, Xue Hu, Yan Wu, Liang Zeng, Yanfeng Yao, Weijuan Shang, Kunpeng Liu, Ge Gao, Weiwei Guo, Yun Peng, Shaohong Chen, Xiaoxiao Gao, Cheng Peng, Juhong Rao, Jiaxuan Zhao, Cheng Gong, Hui Zhou, Yudong Lu, Zili Wang, Xiliang Hu, WenJuan Cong, Lijuan Fang, Yongxiang Yan, Jing Zhang, Hui Xiong, Jizu Yi, Zhiming Yuan, Pengfei Zhou, Chao Shan, Gengfu Xiao

Journal: Cell Discov

PubMed ID: 34493710

Doi: 10.1038/s41421-021-00320-y

Products & Services: Plasmid DNA Preparation

Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo

Authors: Debashis Dutta, Malabendu Jana, Moumita Majumder, Susanta Mondal, Avik Roy, Kalipada Pahan

Journal: Nat Commun

PubMed ID: 34508096

Doi: 10.1038/s41467-021-25767-1

Products & Services: Peptide Synthesis

Mass balance method for SI-traceable purity assignment of synthetic oxytocin

Authors: Sheng Wang, Peize Wu, Ming Li, Ting Huang, Naijie Shi, Liuxing Feng, Hongmei Li

Journal: J Pharm Biomed Anal

PubMed ID: 34656934

Doi: 10.1016/j.jpba.2021.114401

Products & Services: Peptide Synthesis

Surface-enhanced Raman scattering-based detection of plasmin activity by specific peptide substrate

Authors: Nazife Nur Yazgan, Tugba Bulat, Ali Topcu, Fahriye Ceyda Dudak, Ismail Hakki Boyaci, Uğur Tamer

Journal: Food Chem

PubMed ID: 34624781

Doi: 10.1016/j.foodchem.2021.131235

Products & Services: Peptide Synthesis

Identification and Characterization of Rift Valley Fever Virus-Specific T Cells Reveals a Dependence on CD40/CD40L Interactions for Prevention of Encephalitis

Authors: Dominique J Barbeau, Haley N Cartwright, Jessica R Harmon, Jessica R Spengler, Christina F Spiropoulou, John Sidney, Alessandro Sette, Anita K McElroy

Journal: J Virol

PubMed ID: 34495703

Doi: 10.1128/JVI.01506-21

Products & Services: Peptide Synthesis

Optimised Heterologous Expression and Functional Analysis of the F1-Capsular Antigen Regulator Caf1R

Authors: Dharmender K Gahlot, Gyles Ifill, Sheila MacIntyre

Journal: Int J Mol Sci

PubMed ID: 34575967

Doi: 10.3390/ijms22189805

Products & Services: ORF cDNA Clones/MolecularCloud

Glucagon-Like Peptide-2 Modulates Enteric Paneth Cells Immune Response and Alleviates Gut Inflammation During Intravenous Fluid Infusion in Mice With a Central Catheter

Authors: Guifang Deng, Qiucheng Lei, Xuejin Gao, Yupeng Zhang, Huazhen Zheng, Jingcheng Bi, Xinying Wang

Journal: Front Nutr

PubMed ID: 34540875

Doi: 10.3389/fnut.2021.688715

Products & Services: Nucleic Acid Purification & Analysis

Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity

Authors: Ashley C Dougherty, Mariam G Hawaz, Kristine G Hoang, Judy Trac, Jacob M Keck, Carmen Ayes, Joseph E Deweese

Journal: ACS Omega

PubMed ID: 34660952

Doi: 10.1021/acsomega.1c02083

Products & Services: Mutagenesis Services

The DNA Recognition Motif of GapR Has an Intrinsic DNA Binding Preference towards AT-rich DNA

Authors: Qian Huang, Bo Duan, Zhi Qu, Shilong Fan, Bin Xia

Journal: Molecules

PubMed ID: 34641320

Doi: 10.3390/molecules26195776

Products & Services: Mutagenesis Services

Author Correction: Enhanced genome editing efficiency of CRISPR PLUS: Cas9 chimeric fusion proteins

Authors: Jongjin Park, Jiyoung Yoon, Daekee Kwon, Mi-Jung Han, Sunmee Choi, Slki Park, Junghyuk Lee, Kiwook Lee, Jaehwan Lee, Seunghee Lee, Kyung-Sun Kang, Sunghwa Choe

Journal: Sci Rep

PubMed ID: 34508163

Doi: 10.1038/s41598-021-98186-3

Products & Services: Mammalian Expression

Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools

Authors: Viktor Mojr, Mohammad Roghanian, Hedvig Tamman, Duy Dinh Do Pham, Magdalena Petrová, Radek Pohl, Hiraku Takada, Katleen Van Nerom, Hanna Ainelo, Julien Caballero-Montes, Steffi Jimmy, Abel Garcia-Pino, Vasili Hauryliuk, Dominik Rejman

Journal: ACS Chem Biol

PubMed ID: 34477366

Doi: 10.1021/acschembio.1c00398

Products & Services: Mammalian Expression

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

Authors: Eleonora Turco, Adriana Savova, Flora Gere, Luca Ferrari, Julia Romanov, Martina Schuschnig, Sascha Martens

Journal: Nat Commun

PubMed ID: 34471133

Doi: 10.1038/s41467-021-25572-w

Products & Services: Insect Expression

Multiple strategies for metabolic engineering of Escherichia coli for efficient production of glycolate

Authors: Tong Zhu, Die Yao, Di Li, Hongtao Xu, Shiru Jia, Changhao Bi, Jun Cai, Xinna Zhu, Xueli Zhang

Journal: Biotechnol Bioeng

PubMed ID: 34491579

Doi: 10.1002/bit.27934

Products & Services: GenParts™ DNA Fragments

Spectroscopic and functional characterization of the [2Fe-2S] scaffold protein Nfu from Synechocystis PCC6803

Authors: Zechariah Thompson, Insiya Fidai, Christine Wachnowsky, Amber L Hendricks, J A Cowan

Journal: Biochimie

PubMed ID: 34582998

Doi: 10.1016/j.biochi.2021.09.013

Products & Services: Gene Synthesis

CriTER-A: A Novel Temperature-Dependent Noncoding RNA Switch in the Telomeric Transcriptome of

Authors: Cristina Romero-López, Alfredo Berzal-Herranz, José Luis Martínez-Guitarte, Mercedes de la Fuente

Journal: Int J Mol Sci

PubMed ID: 34638651

Doi: 10.3390/ijms221910310

Products & Services: Plasmid DNA Preparation

CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner

Authors: Mohammad Golam Sabbir, Carla G Taylor, Peter Zahradka

Journal: Cell Commun Signal

PubMed ID: 34563205

Doi: 10.1186/s12964-021-00778-z

Products & Services: ORF cDNA Clones/MolecularCloud

Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

Authors: Silvia Leon, Rajae Talbi, Elizabeth A McCarthy, Kaitlin Ferrari, Chrysanthi Fergani, Lydie Naule, Ji Hae Choi, Rona S Carroll, Ursula B Kaiser, Carlos F Aylwin, Alejandro Lomniczi, Víctor M Navarro

Journal: Elife

PubMed ID: 34494548

Doi: 10.7554/eLife.69765

Products & Services: Custom Vector Construction

Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells

Authors: Cesar L Cuevas-Velazquez, Tamara Vellosillo, Karina Guadalupe, Hermann Broder Schmidt, Feng Yu, David Moses, Jennifer A N Brophy, Dante Cosio-Acosta, Alakananda Das, Lingxin Wang, Alexander M Jones, Alejandra A Covarrubias, Shahar Sukenik, José R Dinneny

Journal: Nat Commun

PubMed ID: 34521831

Doi: 10.1038/s41467-021-25736-8

Products & Services: GenParts™ DNA Fragments

A Secreted Chorismate Mutase from pv Attenuates Virulence and Walnut Blight Symptoms

Authors: Renata de A B Assis, Cíntia H D Sagawa, Paulo A Zaini, Houston J Saxe, Phillip A Wilmarth, Brett S Phinney, Michelle Salemi, Leandro M Moreira, Abhaya M Dandekar

Journal: Int J Mol Sci

PubMed ID: 34638715

Doi: 10.3390/ijms221910374

Products & Services: Mutagenesis Services

Elucidating mechanisms of antitumor immunity mediated by live oncolytic vaccinia and heat-inactivated vaccinia

Authors: Weiyi Wang, Shuaitong Liu, Peihong Dai, Ning Yang, Yi Wang, Rachel A Giese, Taha Merghoub, Jedd Wolchok, Liang Deng

Journal: J Immunother Cancer

PubMed ID: 34593618

Doi: 10.1136/jitc-2021-002569

Products & Services: Recombinant Antibody Expression

Altered metabolomic states elicited by Flg22 and FlgII-28 in Solanum lycopersicum: intracellular perturbations and metabolite defenses

Authors: Dylan R Zeiss, Paul A Steenkamp, Lizelle A Piater, Ian A Dubery

Journal: BMC Plant Biol

PubMed ID: 34548030

Doi: 10.1186/s12870-021-03200-5

Products & Services: Catalog Peptides

A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis

Authors: Jie Zheng, Lu Yao, Yijing Zhou, Xiaoqun Gu, Can Wang, Kaifan Bao, Yang Sun, Min Hong

Journal: Cell Death Dis

PubMed ID: 34561424

Doi: 10.1038/s41419-021-04159-9

Products & Services: Custom DNA/RNA Oligos

Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

Authors: Jaime L Chao, Michael Korzinkin, Alex Zhavoronkov, Ivan V Ozerov, Matthew T Walker, Kathleen Higgins, Mark W Lingen, Evgeny Izumchenko, Peter A Savage

Journal: Cell Rep Med

PubMed ID: 34622236

Doi: 10.1016/j.xcrm.2021.100399

Products & Services: Catalog Peptides

Multiplex genome editing in using Mb3Cas12a

Authors: William T Jordan, Seth Currie, Robert J Schmitz

Journal: Plant Direct

PubMed ID: 34514290

Doi: 10.1002/pld3.344

Products & Services: ORF cDNA Clones/MolecularCloud

SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia

Authors: Yiliang Wei, Yu-Han Huang, Damianos S Skopelitis, Shruti V Iyer, Ana S H Costa, Zhaolin Yang, Melissa Kramer, Emmalee R Adelman, Olaf Klingbeil, Osama E Demerdash, Sofya A Polyanskaya, Kenneth Chang, Sara Goodwin, Emily Hodges, W Richard McCombie, Maria E Figueroa, Christopher R Vakoc

Journal: Cancer Discov

PubMed ID: 34531253

Doi: 10.1158/2159-8290.CD-20-1849

Products & Services: Gene Synthesis

Angiogenesis and nerve regeneration induced by local administration of plasmid into the intact rat sciatic nerve

Authors: Ruslan Masgutov, Alina Zeinalova, Alexey Bogov, Galina Masgutova, Ilnur Salafutdinov, Ekaterina Garanina, Valeriia Syromiatnikova, Kamilla Idrisova, Adelya Mullakhmetova, Dina Andreeva, Liliya Mukhametova, Adilet Kadyrov, Igor Pankov, Albert Rizvanov

Journal: Neural Regen Res

PubMed ID: 33510097

Doi: 10.4103/1673-5374.306090

Products & Services: Gene Synthesis

Structural basis for the specificity of PPM1H phosphatase for Rab GTPases

Authors: Dieter Waschbüsch, Kerryn Berndsen, Pawel Lis, Axel Knebel, Yuko Py Lam, Dario R Alessi, Amir R Khan

Journal: EMBO Rep

PubMed ID: 34580980

Doi: 10.15252/embr.202152675

Products & Services: Gene Synthesis

Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

Authors: Yilin Pang, Guoqiang Tan, Xunjun Yang, Yuanshan Lin, Yao Chen, Jinping Zhang, Ting Xie, Huaibin Zhou, Jun Fang, Qiongya Zhao, Xiaojun Ren, Jianghui Li, Jianxin Lyu, Zheng Wang

Journal: Cancer Cell Int

PubMed ID: 34488769

Doi: 10.1186/s12935-021-02131-3

Products & Services: Proteins, Expression, Isolation and Analysis

A Molecular Survey of Bacterial Species in the Guts of Black Soldier Fly Larvae () Reared on Two Urban Organic Waste Streams in Kenya

Authors: Marwa Shumo, Fathiya M Khamis, Fidelis Levi Ombura, Chrysantus M Tanga, Komi K M Fiaboe, Sevgan Subramanian, Sunday Ekesi, Oliver K Schlüter, Arnold van Huis, Christian Borgemeister

Journal: Front Microbiol

PubMed ID: 34630342

Doi: 10.3389/fmicb.2021.687103

Products & Services: DNA Sequencing

Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and Alzheimer's Disease in Amyloid Precursor Protein/Presenilin 1 Mice

Authors: Qing Zeng, Qin Fang, Xincai Zhou, Hongfa Yang, Yang Dou, Wenhao Zhang, Pu Gong, Xianfang Rong

Journal: Front Mol Neurosci

PubMed ID: 34658785

Doi: 10.3389/fnmol.2021.728184

Products & Services: Recombinant Proteins

Epitope Profiling Reveals the Critical Antigenic Determinants in SARS-CoV-2 RBD-Based Antigen

Authors: Min Jiang, Gaiping Zhang, Hongliang Liu, Peiyang Ding, Yunchao Liu, Yuanyuan Tian, Yanwei Wang, Aiping Wang

Journal: Front Immunol

PubMed ID: 34621266

Doi: 10.3389/fimmu.2021.707977

Products & Services: Recombinant Proteins

Perturbation-specific responses by two neural circuits generating similar activity patterns

Authors: Daniel J Powell, Eve Marder, Michael P Nusbaum

Journal: Curr Biol

PubMed ID: 34506730

Doi: 10.1016/j.cub.2021.08.042

Products & Services: Catalog Peptides

Kinetic Characterization of a Putatively Chitin-Active LPMO Reveals a Preference for Soluble Substrates and Absence of Monooxygenase Activity

Authors: Lukas Rieder, Dejan Petrović, Priit Väljamäe, Vincent G H Eijsink, Morten Sørlie

Journal: ACS Catal

PubMed ID: 34567832

Doi: 10.1021/acscatal.1c03344

Products & Services: Codon Optimization

Identification of Optimal Expression Parameters and Purification of a Codon-Optimized Human GLIS1 Transcription Factor from Escherichia coli

Authors: Chandrima Dey, Vishalini Venkatesan, Rajkumar P Thummer

Journal: Mol Biotechnol

PubMed ID: 34528219

Doi: 10.1007/s12033-021-00390-z

Products & Services: Codon Optimization

Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation

Authors: Huan-Li Yang, Xiao-Wu Shi

Journal: Front Neurol

PubMed ID: 34557140

Doi: 10.3389/fneur.2021.659678

Products & Services: Proteins, Expression, Isolation and Analysis

Next-Generation Sequencing Reveals Four Novel Viruses Associated with Calf Diarrhea

Authors: Qi Wu, Jizong Li, Wei Wang, Jinzhu Zhou, Dandan Wang, Baochao Fan, Xuehan Zhang, Dongbo Sun, Ga Gong, Sizhu Suolang, Bin Li

Journal: Viruses

PubMed ID: 34696337

Doi: 10.3390/v13101907

Products & Services: Catalog Antibody

Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals

Authors: Anthony T Tan, Joey Me Lim, Nina Le Bert, Kamini Kunasegaran, Adeline Chia, Martin Dc Qui, Nicole Tan, Wan Ni Chia, Ruklanthi de Alwis, Ding Ying, Jean Xy Sim, Eng Eong Ooi, Lin-Fa Wang, Mark I-Cheng Chen, Barnaby E Young, Li Yang Hsu, Jenny Gh Low, David C Lye, Antonio Bertoletti

Journal: J Clin Invest

PubMed ID: 34623327

Doi: 10.1172/JCI152379

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Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection

Authors: Chao Ye, Weiran Li, Ying Yang, Qingwen Liu, Sijing Li, Peng Zheng, Xiao Zheng, Ye Zhang, Jinrong He, Yongjun Chen, Liangqun Hua, Zhongqian Yang, Duo Li, Zhaoling Ren, Ying Yang, Jialong Qi, Weiwei Huang, Yanbing Ma

Journal: Cell Rep

PubMed ID: 34551309

Doi: 10.1016/j.celrep.2021.109750

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Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition

Authors: Chelsie A Kadgien, Anusha Kamesh, Austen J Milnerwood

Journal: Mol Brain

PubMed ID: 34530877

Doi: 10.1186/s13041-021-00848-w

Products & Services: Catalog Antibody

Production and Purification of Two Bioactive Antimicrobial Peptides Using a Two-Step Approach Involving an Elastin-Like Fusion Tag

Authors: Ana Margarida Pereira, André da Costa, Simoni Campos Dias, Margarida Casal, Raul Machado

Journal: Pharmaceuticals (Basel)

PubMed ID: 34681180

Doi: 10.3390/ph14100956

Products & Services: Gene Synthesis

Differential MMP-14 Targeting by Lumican-Derived Peptides Unraveled by In Silico Approach

Authors: Jonathan Dauvé, Nicolas Belloy, Romain Rivet, Nicolas Etique, Pierre Nizet, Katarzyna Pietraszek-Gremplewicz, Konstantina Karamanou, Manuel Dauchez, Laurent Ramont, Stéphane Brézillon, Stéphanie Baud

Journal: Cancers (Basel)

PubMed ID: 34638415

Doi: 10.3390/cancers13194930

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Titanium Wear Particles Exacerbate -Induced Implant-Related Osteolysis and Decrease Efficacy of Antibiotic Therapy

Authors: Claudia Siverino, Linda Freitag, Daniel Arens, Ursula Styger, R Geoff Richards, T Fintan Moriarty, Vincent A Stadelmann, Keith Thompson

Journal: Microorganisms

PubMed ID: 34576840

Doi: 10.3390/microorganisms9091945

Products & Services: Proteins, Expression, Isolation and Analysis

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