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Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity

Authors: Shang Yu Gong, Debashree Chatterjee, Jonathan Richard, Jérémie Prévost, Alexandra Tauzin, Romain Gasser, Yuxia Bo, Dani Vézina, Guillaume Goyette, Gabrielle Gendron-Lepage, Halima Medjahed, Michel Roger, Marceline Côté, Andrés Finzi

Journal: Virology

PubMed ID: 34536797

Doi: 10.1016/j.virol.2021.09.001

Products & Services: Recombinant Proteins

Expression of IL-20 Receptor Subunit β Is Linked to EAE Neuropathology and CNS Neuroinflammation

Authors: Jacquelyn R Dayton, Yinyu Yuan, Lisa P Pacumio, Bryce G Dorflinger, Samantha C Yoo, Mariah J Olson, Sara I Hernández-Suárez, Moira M McMahon, Lillian Cruz-Orengo

Journal: Front Cell Neurosci

PubMed ID: 34557075

Doi: 10.3389/fncel.2021.683687

Products & Services: Recombinant Proteins

Mucosal IgA response elicited by intranasal immunization of Lactobacillus plantarum expressing surface-displayed RBD protein of SARS-CoV-2

Authors: Letian Li, Maopeng Wang, Jiayi Hao, Jicheng Han, Tingting Fu, Jieying Bai, Mingyao Tian, Ningyi Jin, Guangze Zhu, Chang Li

Journal: Int J Biol Macromol

PubMed ID: 34499954

Doi: 10.1016/j.ijbiomac.2021.08.232

Products & Services: Monoclonal Antibody Services

Genome-scale identification of () family genes and molecular characterization of their responses to diverse nutrient stresses in allotetraploid rapeseed

Authors: Ying Liu, Ying-Peng Hua, Huan Chen, Ting Zhou, Cai-Peng Yue, Jin-Yong Huang

Journal: PeerJ

PubMed ID: 34603847

Doi: 10.7717/peerj.12007

Products & Services: Protein Tools

Physiologically Relevant Free Ca Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6

Authors: Brianna D Young, Kristen M Varney, Paul T Wilder, Brianna K Costabile, Edwin Pozharski, Mary E Cook, Raquel Godoy-Ruiz, Oliver B Clarke, Filippo Mancia, David J Weber

Journal: J Mol Biol

PubMed ID: 34592217

Doi: 10.1016/j.jmb.2021.167272

Products & Services: Proteins, Expression, Isolation and Analysis

Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription

Authors: John Pang, Nam Nguyen, Jens Luebeck, Laurel Ball, Andrey Finegersh, Shuling Ren, Takuya Nakagawa, Mitchell Flagg, Sayed Sadat, Paul S Mischel, Guorong Xu, Kathleen Fisch, Theresa Guo, Gabrielle Cahill, Bharat Panuganti, Vineet Bafna, Joseph Califano

Journal: Clin Cancer Res

PubMed ID: 34548317

Doi: 10.1158/1078-0432.CCR-21-2484

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A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels

Authors: Juliano Alves, Laurie Engel, Renata de Vasconcelos Cabral, Eduardo L Rodrigues, Liane de Jesus Ribeiro, Luiza M Higa, Orlando da Costa Ferreira Júnior, Terezinha Marta P P Castiñeiras, Isabela de Carvalho Leitão, Amilcar Tanuri, Said A Goueli, Hicham Zegzouti

Journal: Sci Rep

PubMed ID: 34531417

Doi: 10.1038/s41598-021-97330-3

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The impact of chromophore choice on the assembly kinetics and primary photochemistry of a red/green cyanobacteriochrome

Authors:

Journal: Phys Chem Chem Phys

PubMed ID: 34374395

Doi: 10.1039/d1cp02696h

Products & Services: Bacterial Expression

DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation

Authors: Hung-Hsi Chen, Hsin-I Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu, Shu-Chun Lin, Muh-Hwa Yang, Woan-Yuh Tarn

Journal: iScience

PubMed ID: 34568799

Doi: 10.1016/j.isci.2021.103086

Products & Services: Catalog Antibody

Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2

Authors: Raymond Rowland, Alberto Brandariz-Nuñez

Journal: Microbiol Spectr

PubMed ID: 34494876

Doi: 10.1128/Spectrum.01199-21

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The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

Authors: Yue Xi, Yanping Li, Pengfei Xu, Sihan Li, Zhengsheng Liu, Hung-Chun Tung, Xinran Cai, Jingyuan Wang, Haozhe Huang, Menglin Wang, Meishu Xu, Songrong Ren, Song Li, Min Zhang, Yong J Lee, Leaf Huang, Da Yang, Jinhan He, Zhiying Huang, Wen Xie

Journal: Sci Adv

PubMed ID: 34516906

Doi: 10.1126/sciadv.abg9241

Products & Services: Plasmid DNA Preparation

Oncogenic Truncations of ASXL1 Enhance a Motif for BRD4 ET-Domain Binding

Authors: Abigail E Burgess, Torsten Kleffmann, Peter D Mace

Journal: J Mol Biol

PubMed ID: 34536441

Doi: 10.1016/j.jmb.2021.167242

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Impact of glgA1, glgA2 or glgC overexpression on growth and glycogen production in Synechocystis sp PCC 6803

Authors: Sandra Mittermair, Gergely Lakatos, Cecilia Nicoletti, Karolína Ranglová, João Câmara Manoel, Tomáš Grivalský, Daniyar Malikuly Kozhan, Jiří Masojídek, Juliane Richter

Journal: J Biotechnol

PubMed ID: 34481001

Doi: 10.1016/j.jbiotec.2021.08.012

Products & Services: Proteins, Expression, Isolation and Analysis

Distinct Effects of Escitalopram and Vortioxetine on Astroglial L-Glutamate Release Associated with Connexin43

Authors: Takashi Shiroyama, Kouji Fukuyama, Motohiro Okada

Journal: Int J Mol Sci

PubMed ID: 34576176

Doi: 10.3390/ijms221810013

Products & Services: Proteins, Expression, Isolation and Analysis

Switchable immune modulator for tumor-specific activation of anticancer immunity

Authors: Yu Zhao, Yu-Qing Xie, Simon Van Herck, Sina Nassiri, Min Gao, Yugang Guo, Li Tang

Journal: Sci Adv

PubMed ID: 34516776

Doi: 10.1126/sciadv.abg7291

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A structural view onto disease-linked mutations in the human neutral amino acid exchanger ASCT1

Authors: Pavlo Stehantsev, Artem Stetsenko, Mariia Nemchinova, Nanda Gowtham Aduri, Siewert J Marrink, Cornelius Gati, Albert Guskov

Journal: Comput Struct Biotechnol J

PubMed ID: 34630942

Doi: 10.1016/j.csbj.2021.09.015

Products & Services: Mammalian Expression

Selective autophagic receptor NbNBR1 prevents NbRFP1-mediated UPS-dependent degradation of βC1 to promote geminivirus infection

Authors: Tingting Zhou, Mingzhen Zhang, Pan Gong, Fangfang Li, Xueping Zhou

Journal: PLoS Pathog

PubMed ID: 34570833

Doi: 10.1371/journal.ppat.1009956

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The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients

Authors: Chanmi Kim, Iqra Latif, Durga P Neupane, Gi Young Lee, Ryan S Kwon, Alia Batool, Qasim Ahmed, Muhammad Usman Qamar, Jeongmin Song

Journal: PLoS ONE

PubMed ID: 34582469

Doi: 10.1371/journal.pone.0257744

Products & Services: PCR and Cloning

A new carbohydrate-active oligosaccharide dehydratase is involved in the degradation of ulvan

Authors: Marcus Bäumgen, Theresa Dutschei, Daniel Bartosik, Christoph Suster, Lukas Reisky, Nadine Gerlach, Christian Stanetty, Marko D Mihovilovic, Thomas Schweder, Jan-Hendrik Hehemann, Uwe T Bornscheuer

Journal: J Biol Chem

PubMed ID: 34547290

Doi: 10.1016/j.jbc.2021.101210

Products & Services: PCR Cloning and Subcloning

Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons

Authors: Hung-En Hsia, Johanna Tüshaus, Xiao Feng, Laura I Hofmann, Benedikt Wefers, Denise K Marciano, Wolfgang Wurst, Stefan F Lichtenthaler

Journal: FASEB J

PubMed ID: 34390512

Doi: 10.1096/fj.202100475R

Products & Services: Proteins, Expression, Isolation and Analysis

Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens

Authors: Andrew J Monteith, Jeanette M Miller, C Noel Maxwell, Walter J Chazin, Eric P Skaar

Journal: Sci Adv

PubMed ID: 34516771

Doi: 10.1126/sciadv.abj2101

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Design and Selection of Engineered Lytic Proteins With Decolonizing Activity

Authors: Diana Gutiérrez, Lorena Rodríguez-Rubio, Patricia Ruas-Madiedo, Lucía Fernández, Ana Belén Campelo, Yves Briers, Martin Weiss Nielsen, Karl Pedersen, Rob Lavigne, Pilar García, Ana Rodríguez

Journal: Front Microbiol

PubMed ID: 34594314

Doi: 10.3389/fmicb.2021.723834

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A phage-encoded nucleoid associated protein compacts both host and phage DNA and derepresses H-NS silencing

Authors: Bokyung Son, Jennifer Patterson-West, Melissa Arroyo-Mendoza, Revathy Ramachandran, James R Iben, Jingen Zhu, Venigalla Rao, Emilios K Dimitriadis, Deborah M Hinton

Journal: Nucleic Acids Res

PubMed ID: 34365505

Doi: 10.1093/nar/gkab678

Products & Services: Gene Synthesis

miR‑32‑5p suppresses the proliferation and migration of pancreatic adenocarcinoma cells by targeting TLDC1

Authors: Peng Yuan, Chaofeng Tang, Bendong Chen, Peng Lei, Jianjun Song, Guojun Xin, Zuozheng Wang, Yongfeng Hui, Weijie Yao, Genwang Wang, Guozhong Zhao

Journal: Mol Med Rep

PubMed ID: 34468015

Doi: 10.3892/mmr.2021.12392

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Long noncoding RNA LAMTOR5-AS1 interference affects microRNA-506-3p/E2F6-mediated behavior of non-small cell lung cancer cells

Authors: Guojie Chen, Kai Wang, Guoshu Li, Leidong Wang, Yangyang Xiao, Bo Chen

Journal: Oncol Res

PubMed ID: 34588094

Doi: 10.3727/096504021X16328213967104

Products & Services: Gene Synthesis

Myeloma patients with COVID-19 have superior antibody responses compared to patients fully vaccinated with the BNT162b2 vaccine

Authors: Maria Gavriatopoulou, Evangelos Terpos, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, Alexandros Briasoulis, Sentiljana Gumeni, Despina Fotiou, Eleni-Dimitra Papanagnou, Magdalini Migkou, Foteini Theodorakakou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Ioannis P Trougakos, Efstathios Kastritis, Meletios-Athanasios Dimopoulos

Journal: Br J Haematol

PubMed ID: 34528249

Doi: 10.1111/bjh.17841

Products & Services: PCR and Cloning

A human antibody against human endothelin receptor type A that exhibits antitumor potency

Authors: Man-Seok Ju, Hye-Mi Ahn, Seong-Gu Han, Sanghwan Ko, Jung-Hyun Na, Migyeong Jo, Chung Su Lim, Byoung Joon Ko, Yeon Gyu Yu, Won-Kyu Lee, Youn-Jae Kim, Sang Taek Jung

Journal: Exp Mol Med

PubMed ID: 34588605

Doi: 10.1038/s12276-021-00678-9

Products & Services: Proteins, Expression, Isolation and Analysis

Genome editing with type II-C CRISPR-Cas9 systems from Neisseria meningitidis in rice

Authors: Rongfang Xu, Ruiying Qin, Hongjun Xie, Juan Li, Xiaoshuang Liu, Mingdong Zhu, Yang Sun, Yinghong Yu, Pingli Lu, Pengcheng Wei

Journal: Plant Biotechnol J

PubMed ID: 34582079

Doi: 10.1111/pbi.13716

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Neutralizing Antibodies against SARS-CoV-2, Anti-Ad5 Antibodies, and Reactogenicity in Response to Ad5-nCoV (CanSino Biologics) Vaccine in Individuals with and without Prior SARS-CoV-2

Authors: Jorge Hernández-Bello, José Javier Morales-Núñez, Andrea Carolina Machado-Sulbarán, Saúl Alberto Díaz-Pérez, Paola Carolina Torres-Hernández, Paulina Balcázar-Félix, Jesús Alberto Gutiérrez-Brito, José Alvaro Lomelí-Nieto, José Francisco Muñoz-Valle

Journal: Vaccines (Basel)

PubMed ID: 34579284

Doi: 10.3390/vaccines9091047

Modulation of heterologous protein secretion in the thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC 656 by CRISPR-Cas9 system

Authors: Worarat Kruasuwan, Aekkachai Puseenam, Chitwadee Phithakrotchanakoon, Sutipa Tanapongpipat, Niran Roongsawang

Journal: PLoS ONE

PubMed ID: 34582499

Doi: 10.1371/journal.pone.0258005

Products & Services: Gene Synthesis

An analysis of antibody responses and clinical sequalae of the Sinopharm HB02 COVID19 vaccine in dialysis patients in the United Arab Emirates

Authors: Stephen Geoffrey Holt, Sally Mahmoud, Wasim Ahmed, Juan Manuel Acuna, Ayman Kamal Al Madani, Islam Eltantawy, Walid Abbas Zaher, Gareth John Goodier, Nawal Ahmed Al Kaabi, Ali Abdulkareem Al Obaidli

Journal: Nephrology (Carlton)

PubMed ID: 34569677

Doi: 10.1111/nep.13980

The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation

Authors: Izzy Owen, Debra Yee, Hala Wyne, Theodora Myrto Perdikari, Victoria Johnson, Jeremy Smyth, Robert Kortum, Nicolas L Fawzi, Frank Shewmaker

Journal: J Cell Sci

PubMed ID: 34357401

Doi: 10.1242/jcs.258578

Products & Services: Proteins, Expression, Isolation and Analysis

ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier

Authors: Xihua Yue , Yi Qian , Lianhui Zhu , Bopil Gim, Mengjing Bao , Jie Jia , Shuaiyang Jing , Yijing Wang , Chuanting Tan , Francesca Bottanelli , Pascal Ziltener , Sunkyu Choi , Piliang Hao , Intaek Lee

Journal: BMC Biol

PubMed ID: 34493279

Doi: 10.1186/s12915-021-01137-7

Products & Services: Proteins, Expression, Isolation and Analysis

Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation

Authors: Hongyi Zhou, Huabo Su, Weiqin Chen

Journal: Int J Mol Sci

PubMed ID: 34502418

Doi: 10.3390/ijms22179509

Products & Services: CRISPR Plasmids

A Cross-Reactive Monoclonal Antibody Against Neuraminidases of Both H9N2 and H3N2 Influenza Viruses Shows Protection in Mice Challenging Models

Authors: Fei Wang, Zhimin Wan, Jinsen Wu, Yajuan Wang, Hui Fu, Hongxia Shao, Kun Qian, Wei Gao, Jianqiang, Aijian Qin

Journal: Frontiers in Microbiology

Doi: 10.3389/fmicb.2021.730449

Products & Services: Gene Synthesis

Application of the amplification-free SERS-based CRISPR/Cas12a platform in the identification of SARS-CoV-2 from clinical samples

Authors: Jiajie Liang, Peijun Teng, Wei Xiao, Guanbo He, Qifang Song, Ying Zhang, Bin Peng, Gan Li, Liangshan Hu, Donglin Cao, Yong Tang

Journal: J Nanobiotechnology

PubMed ID: 34496881

Doi: 10.1186/s12951-021-01021-0

Products & Services: DNA Sequencing

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Authors: Stephanie Patchett, Zongyang Lv, Wioletta Rut, Miklos Békés, Marcin Drag, Shaun K Olsen, Tony T Huang

Journal: Cell Rep

PubMed ID: 34547223

Doi: 10.1016/j.celrep.2021.109754

Products & Services: DNA Sequencing

Fusion of cellobiose phosphorylase and potato alpha-glucan phosphorylase facilitates substrate channeling for enzymatic conversion of cellobiose to starch

Authors: Xinyu Liu, Huawei Hou, Yapeng Li, Sen Yang, Hui Lin, Hongge Chen

Journal: Prep Biochem Biotechnol

PubMed ID: 34550864

Doi: 10.1080/10826068.2021.1977949

Products & Services: DNA Sequencing

Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae

Authors: Nagakumar Bharatham, Purnendu Bhowmik, Maho Aoki, Ui Okada, Sreevalli Sharma, Eiki Yamashita, Anirudh P Shanbhag, Sreenath Rajagopal, Teby Thomas, Maitrayee Sarma, Riya Narjari, Savitha Nagaraj, Vasanthi Ramachandran, Nainesh Katagihallimath, Santanu Datta, Satoshi Murakami

Journal: Nat Commun

PubMed ID: 34518546

Doi: 10.1038/s41467-021-25679-0

Products & Services: DNA Sequencing

Association of a GATA Binding Protein 4 Polymorphism with the Risk of Hypospadias in the Chinese Children

Authors: Jiawei Chen, Xinhai Cui, Aiwu Li, Guowei Li, Fengyin Sun

Journal: Urol Int

PubMed ID: 34569527

Doi: 10.1159/000518644

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NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain

Authors: Bing Wang, Dmitri Svetlov, Irina Artsimovitch

Journal: Nucleic Acids Res

PubMed ID: 34352100

Doi: 10.1093/nar/gkab677

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A genome-wide screen reveals the involvement of enterobactin-mediated iron acquisition in Escherichia coli survival during copper stress

Authors: Kaitlin Casanova-Hampton, Alexis Carey, Sarah Kassam, Alyssa Garner, George L Donati, Shankar Thangamani, Sargurunathan Subashchandrabose

Journal: Metallomics

PubMed ID: 34415046

Doi: 10.1093/mtomcs/mfab052

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De novo design of tyrosine and serine kinase-driven protein switches

Authors: Nicholas B Woodall, Zara Weinberg, Jesslyn Park, Florian Busch, Richard S Johnson, Mikayla J Feldbauer, Michael Murphy, Maggie Ahlrichs, Issa Yousif, Michael J MacCoss, Vicki H Wysocki, Hana El-Samad, David Baker

Journal: Nat Struct Mol Biol

PubMed ID: 34518698

Doi: 10.1038/s41594-021-00649-8

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The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity

Authors: Konrad J Mostert, Nandini Sharma, Marianne van der Zwaag, Roxine Staats, Lizbé Koekemoer, Ruchi Anand, Ody C M Sibon, Erick Strauss

Journal: ACS Chem Biol

PubMed ID: 34582681

Doi: 10.1021/acschembio.1c00535

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Feline thymidine kinase 1: molecular characterization and evaluation of its serum form as a diagnostic biomarker

Authors: Liya Wang, Hanan Sharif, Sara Saellström, Henrik Rönnberg, Staffan Eriksson

Journal: BMC Vet Res

PubMed ID: 34579716

Doi: 10.1186/s12917-021-03030-5

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Molecular basis of human ATM kinase inhibition

Authors: K Stakyte, M Rotheneder, K Lammens, J D Bartho, U Grädler, T Fuchß, U Pehl, A Alt, E van de Logt, K P Hopfner

Journal: Nat Struct Mol Biol

PubMed ID: 34556870

Doi: 10.1038/s41594-021-00654-x

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Zinc-finger protein MdBBX7/MdCOL9, a target of MdMIEL1 E3 ligase, confers drought tolerance in apple

Authors: Pengxiang Chen, Fang Zhi, Xuewei Li, Wenyun Shen, Mingjia Yan, Jieqiang He, Chana Bao, Tianle Fan, Shuangxi Zhou, Fengwang Ma, Qingmei Guan

Journal: Plant Physiol

PubMed ID: 34618120

Doi: 10.1093/plphys/kiab420

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Spectroscopic evidence of tetanus toxin translocation domain bilayer-induced refolding and insertion

Authors: Pierce T O'Neil, Victor Vasquez-Montes, Liskin Swint-Kruse, Michael R Baldwin, Alexey S Ladokhin

Journal: Biophys J

PubMed ID: 34555358

Doi: 10.1016/j.bpj.2021.09.030

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Spike protein of SARS-CoV-2 activates macrophages and contributes to induction of acute lung inflammation in male mice

Authors: Xiaoling Cao, Yan Tian, Vi Nguyen, Yuping Zhang, Chao Gao, Rong Yin, Wayne Carver, Daping Fan, Helmut Albrecht, Taixing Cui, Wenbin Tan

Journal: FASEB J

PubMed ID: 34365657

Doi: 10.1096/fj.202002742RR

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Biomimetic and mechanically supportive 3D printed scaffolds for cartilage and osteochondral tissue engineering using photopolymers and digital light processing

Authors: Sarah A Schoonraad, Kristine M Fischenich, Kevin N Eckstein, Victor Crespo-Cuevas, Lea M Savard, Archish Muralidharan, Andrew A Tomaschke, Asais Camila Uzcategui, Mark A Randolph, Robert R McLeod, Virginia L Ferguson, Stephanie J Bryant

Journal: Biofabrication

PubMed ID: 34479218

Doi: 10.1088/1758-5090/ac23ab

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