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Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule, in healthy adults: interim results from two single-centre, double-blind, randomised, placebo-controlled phase 2 clinical trials

Authors: Gang Zeng, Qianhui Wu, Hongxing Pan, Minjie Li, Juan Yang, Lin Wang, Zhiwei Wu, Deyu Jiang, Xiaowei Deng, Kai Chu, Wen Zheng, Lei Wang, Wanying Lu, Bihua Han, Yuliang Zhao, Fengcai Zhu, Hongjie Yu, Weidong Yin

Journal: Lancet Infect Dis

PubMed ID: 34890537

Doi: 10.1016/S1473-3099(21)00681-2

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A new self-attenuated therapeutic influenza vaccine that uses host cell-restricted attenuation by artificial microRNAs

Authors: Ke Wen, Haiyan Wang, Yanping Chen, Huixiao Yang, Zhichao Zheng, Yongyong Yan, Realivazquez Adilene, Mingtao Zeng

Journal: Int J Pharm

PubMed ID: 34883209

Doi: 10.1016/j.ijpharm.2021.121325

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Cloning and functional identification of setaria italica somatic embryogenesis receptor-like kinase1 gene (SiSERK1)

Authors: Guofan Wu, Wenbo Li, Nongfu Tian, Xin Wang, Wangze Wu, Sheng Zheng

Journal: Gene

PubMed ID: 34902513

Doi: 10.1016/j.gene.2021.146119

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Motif-driven protein binder design towards transferrin receptor helical domain

Authors: Dick J Sjöström, Camilla Mohlin, Elena Ambrosetti, Scott J Garforth, Ana I Teixeira, Sinisa Bjelic

Journal: FEBS J

PubMed ID: 34862739

Doi: 10.1111/febs.16311

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Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

Authors: Moustafa T Mabrouk, Kevin Chiem, Edurne Rujas, Wei-Chiao Huang, Dushyant Jahagirdar, Breandan Quinn, Meera Surendran Nair, Ruth H Nissly, Victoria S Cavener, Nina R Boyle, Ty A Sornberger, Suresh V Kuchipudi, Joaquin Ortega, Jean-Philippe Julien, Luis Martinez-Sobrido, Jonathan Lovell

Journal: Sci Adv

PubMed ID: 34851667

Doi: 10.1126/sciadv.abj1476

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Antifungal activity and mode of action of synthetic peptides derived from the tick OsDef2 defensin

Authors: Kabuzi R Mbuayama, Helena Taute, Adam A Strӧmstedt, Megan J Bester, Anabella R M Gaspar

Journal: J Pept Sci

PubMed ID: 34866278

Doi: 10.1002/psc.3383

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Barcoded reciprocal hemizygosity analysis via sequencing illuminates the complex genetic basis of yeast thermotolerance

Authors: Melanie B Abrams, Julie N Chuong, Faisal AlZaben, Claire A Dubin, Jeffrey M Skerker, Rachel B Brem

Journal: G3 (Bethesda)

PubMed ID: 34878132

Doi: 10.1093/g3journal/jkab412

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Architecture of the chloroplast PSI-NDH supercomplex in Hordeum vulgare

Authors: Liangliang Shen, Kailu Tang, Wenda Wang, Chen Wang, Hangjun Wu, Zhiyuan Mao, Shaoya An, Shenghai Chang, Tingyun Kuang, Jian-Ren Shen, Guangye Han, Xing Zhang

Journal: Nature

PubMed ID: 34879391

Doi: 10.1038/s41586-021-04277-6

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Selective suppression of IL-10 transcription by calcineurin in dendritic cells through inactivation of CREB

Authors: Xiuyuan Lu, Masatsugu Oh-Hora, Kiyoshi Takeda, Sho Yamasaki

Journal: Int Immunol

PubMed ID: 34953165

Doi: 10.1093/intimm/dxab112

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Simplified Point-of-Care Full SARS-CoV-2 Genome Sequencing Using Nanopore Technology

Authors: Anton Pembaur, Erwan Sallard, Patrick Philipp Weil, Jennifer Ortelt, Parviz Ahmad-Nejad, Jan Postberg

Journal: Microorganisms

PubMed ID: 34946199

Doi: 10.3390/microorganisms9122598

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Bio inspired growth factor loaded self assembling peptide nano hydrogel for chronic wound healing

Authors: E Santhini, R Parthasarathy, M Shalini, S Dhivya, L Amalorpava Mary, V Vijaya Padma

Journal: Int J Biol Macromol

PubMed ID: 34920072

Doi: 10.1016/j.ijbiomac.2021.12.026

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Hsa_circ_0003204 Knockdown Weakens Ox-LDL-Induced Cell Injury by Regulating miR-188-3p/TRPC6 Axis in Human Carotid Artery Endothelial Cells and THP-1 Cells

Authors: Wenjia Peng, Shuai Li, Shiyue Chen, Jiacheng Yang, Ze Sun

Journal: Front Cardiovasc Med

PubMed ID: 34912856

Doi: 10.3389/fcvm.2021.731890

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Highly portable quantitative screening test for prostate-specific antigen at point of care

Authors: Balaji Srinivasan, David M Nanus, David Erickson, Saurabh Mehta

Journal: Curr Res Biotechnol

PubMed ID: 35083431

Doi: 10.1016/j.crbiot.2021.11.003

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Phytochrome interacting factor 3 regulates pollen mitotic division through auxin signalling and sugar metabolism pathways in tomato

Authors: Dandan Yang, Yue Liu, Muhammad Ali, Lei Ye, Changtian Pan, Mengzhuo Li, Xiaolin Zhao, Fangjie Yu, Xinai Zhao, Gang Lu

Journal: New Phytol

PubMed ID: 34812499

Doi: 10.1111/nph.17878

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Immunoglobulin a suppresses B cell receptor-mediated activation of mouse B cells with differential inhibition of signaling molecules

Authors: Kouya Yamaki, Masato Terashi, Saori Yamamoto, Rei Fujiwara, Jun-Ichi Inoue, Kishi Shimizu, Sakura Yanagita, Yuma Doi, Kei-Ichiro Kimura, Kayo Kotani, Mai Sugihara, Yutaka Koyama

Journal: Immunopharmacol Immunotoxicol

PubMed ID: 34844505

Doi: 10.1080/08923973.2021.2006216

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Robust Antibody Levels in Both Diabetic and Non-Diabetic Individuals After BNT162b2 mRNA COVID-19 Vaccination

Authors: Hamad Ali, Abdulmohsen Alterki, Sardar Sindhu, Barrak Alahmad, Maha Hammad, Salman Al-Sabah, Mohammad Alghounaim, Mohammad H Jamal, Ali Aldei, Mohammad J Mairza, Maitham Husain, Sriraman Deverajan, Rasheed Ahmad, Preethi Cherian, Irina Alkhairi, Abdullah Alkandari, Jehad Abubaker, Mohamed Abu-Farha, Fahd Al-Mulla

Journal: Front Immunol

PubMed ID: 34899701

Doi: 10.3389/fimmu.2021.752233

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Generation of a Novel High-Affinity Antibody Binding to PCSK9 Catalytic Domain with Slow Dissociation Rate by CDR-Grafting, Alanine Scanning and Saturated Site-Directed Mutagenesis for Favorably Treating Hypercholesterolemia

Authors: Zhengli Bai, Menglong Xu, Ying Mei, Tuo Hu, Panpan Zhang, Manman Chen, Wenxiu Lv, Chenchen Lu, Shuhua Tan

Journal: Biomedicines

PubMed ID: 34944600

Doi: 10.3390/biomedicines9121783

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Methodology to Quantify Collagen Subtypes and Crosslinks: Application in Minipig Cartilages

Authors: Benjamin J Bielajew, Jerry C Hu, Kyriacos A Athanasiou

Journal: Cartilage

PubMed ID: 34823380

Doi: 10.1177/19476035211060508

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Delayed fractional dosing with RTS,S/AS01 improves humoral immunity to malaria via a balance of polyfunctional NANP6- and Pf16-specific antibodies

Authors: Jishnu Das, Jonathan K Fallon, Timothy C Yu, Ashlin Michell, Todd J Suscovich, Caitlyn Linde, Harini Natarajan, Joshua Weiner, Margherita Coccia, Scott Gregory, Margaret E Ackerman, Elke Bergmann-Leitner, Laura Fontana, Sheetij Dutta, Douglas A Lauffenburger, Erik Jongert, Ulrike Wille-Reece, Galit Alter

Journal: Med (N Y)

PubMed ID: 35590199

Doi: 10.1016/j.medj.2021.10.003

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Eurasian Avian-like M1 Plays More Important Role than M2 in Pathogenicity of 2009 Pandemic H1N1 Influenza Virus in Mice

Authors: Lixiang Xie, Guanlong Xu, Lingxiang Xin, Zhaofei Wang, Rujuan Wu, Mingqing Wu, Yuqiang Cheng, Hengan Wang, Yaxian Yan, Jingjiao Ma, Jianhe Sun

Journal: Viruses

PubMed ID: 34960604

Doi: 10.3390/v13122335

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Immuno-transcriptomic profiling of extracranial pediatric solid malignancies

Authors: Andrew S Brohl, Sivasish Sindiri, Jun S Wei, David Milewski, Hsien-Chao Chou, Young K Song, Xinyu Wen, Jeetendra Kumar, Hue V Reardon, Uma S Mudunuri, Jack R Collins, Sushma Nagaraj, Vineela Gangalapudi, Manoj Tyagi, Yuelin J Zhu, Katherine E Masih, Marielle E Yohe, Jack F Shern, Yue Qi, Udayan Guha, Daniel Catchpoole, Rimas J Orentas, Igor B Kuznetsov, Nicolas J Llosa, John A Ligon, Brian K Turpin, Daniel G Leino, Shintaro Iwata, Irene L Andrulis, Jay S Wunder, Silvia R C Toledo, Paul S Meltzer, Ching Lau, Beverly A Teicher, Heather Magnan, Marc Ladanyi, Javed Khan

Journal: Cell Rep

PubMed ID: 34818552

Doi: 10.1016/j.celrep.2021.110047

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ACE Inhibitory Peptide from Skin Collagen Hydrolysate of as Potential for Protecting HUVECs Injury

Authors: Shuilin Cai, Nan Pan, Min Xu, Yongchang Su, Kun Qiao, Bei Chen, Bingde Zheng, Meitian Xiao, Zhiyu Liu

Journal: Mar Drugs

PubMed ID: 34940654

Doi: 10.3390/md19120655

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Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors

Authors: Kira Gysel, Mette Laursen, Mikkel B Thygesen, Damiano Lironi, Zoltán Bozsóki, Christian T Hjuler, Nicolai N Maolanon, Jeryl Cheng, Peter K Bjørk, Maria Vinther, Lene H Madsen, Henriette Rübsam, Artur Muszyński, Arshia Ghodrati, Parastoo Azadi, John T Sullivan, Clive W Ronson, Knud J Jensen, Mickaël Blaise, Simona Radutoiu, Jens Stougaard, Kasper R Andersen

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34716271

Doi: 10.1073/pnas.2111031118

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A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants

Authors: Novalia Pishesha, Thibault J Harmand, Paul W Rothlauf, Patrique Praest, Ryan K Alexander, Renate van den Doel, Mariel J Liebeskind, Maria A Vakaki, Nicholas McCaul, Charlotte Wijne, Elisha Verhaar, William Pinney, Hailey Heston, Louis-Marie Bloyet, Marjorie Cornejo Pontelli, Ma Xenia G Ilagan, Robert Jan Lebbink, William J Buchser, Emmanuel J H J Wiertz, Sean P J Whelan, Hidde L Ploegh

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34654739

Doi: 10.1073/pnas.2116147118

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First cases of SARS-CoV-2 infection in dogs and cats in Thailand

Authors: Waleemas Jairak, Kamonpan Charoenkul, Ekkapat Chamsai, Kitikhun Udom, Supassama Chaiyawong, Napawan Bunpapong, Supanat Boonyapisitsopa, Rachod Tantilertcharoen, Navapon Techakriengkrai, Sirilak Surachetpong, Ratanaporn Tangwangvivat, Kamol Suwannakarn, Alongkorn Amonsin

Journal: Transbound Emerg Dis

PubMed ID: 34739748

Doi: 10.1111/tbed.14383

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

Authors: Yaozong Chen, Lulu Sun, Irfan Ullah, Guillaume Beaudoin-Bussières, Sai Priya Anand, Andrew P Hederman, William D Tolbert, Rebekah Sherburn, Dung N Nguyen, Lorie Marchitto, Shilei Ding, Di Wu, Yuhong Luo, Suneetha Gottumukkala, Sean Moran, Priti Kumar, Grzegorz Piszczek, Walther Mothes, Margaret E Ackerman, Andrés Finzi, Pradeep D Uchil, Frank J Gonzalez, Marzena Pazgier

Journal: biorxiv

PubMed ID: 34845451

Doi: 10.1101/2021.11.24.469776

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Design of a Novel Fab-Like Antibody Fragment with Enhanced Stability and Affinity for Clinical use

Authors: Chunyu Wang, Jiaxu Hong, Zhenlin Yang, Xujiao Zhou, Yuhan Yang, Yu Kong, Binfan Chen, Huifang Wu, Bin-Zhi Qian, Dimiter S Dimitrov, Xingtao Zhou, Yanling Wu, Tianlei Ying

Journal: Small Methods

PubMed ID: 35174992

Doi: 10.1002/smtd.202100966

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High-throughput Microwell-seq 2.0 profiles massively multiplexed chemical perturbation

Authors: Haide Chen, Yuan Liao, Guodong Zhang , Zhongyi Sun, Lei Yang, Xing Fang, Huiyu Sun, Lifeng Ma, Yuting Fu, Jingyu Li, Qile Guo, Xiaoping Han, Guoji Guo

Journal: Cell Discov

PubMed ID: 34750394

Doi: 10.1038/s41421-021-00333-7

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Secretion of Gluconic Acid From sp L1 Is Responsible for Solubilization of Aluminum Phosphate

Authors: Xiao Li Li, Xue Qiang Zhao, Xiao Ying Dong, Jian Feng Ma, Ren Fang Shen

Journal: Front Microbiol

PubMed ID: 34867925

Doi: 10.3389/fmicb.2021.784025

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Vertical transmission of maternal COVID-19 antibodies after CoronaVac vaccine: A case report

Authors: Bruno Thizon Menegali, Fabiana Schuelter-Trevisol, Alexandre Naime Barbosa, Talita Menegali Izidoro, Otto Henrique May Feurschuette, Chaiana Esmeraldino Mendes Marcon, Daisson José Trevisol

Journal: Rev Soc Bras Med Trop

PubMed ID: 34787263

Doi: 10.1590/0037-8682-0385-2021

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A novel framework integrating AI model and enzymological experiments promotes identification of SARS-CoV-2 3CL protease inhibitors and activity-based probe

Authors: Fan Hu, Lei Wang, Yishen Hu, Dongqi Wang, Weijie Wang, Jianbing Jiang, Nan Li, Peng Yin

Journal: Brief Bioinform

PubMed ID: 34368837

Doi: 10.1093/bib/bbab301

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Bioinspired gelatin/bioceramic composites loaded with bone morphogenetic protein-2 (BMP-2) promote osteoporotic bone repair

Authors: M C Echave, I Erezuma, N Golafshan, M Castilho, F B Kadumudi, C Pimenta-Lopes, F Ventura, A Pujol, J J Jimenez, J A Camara, R Hernáez-Moya, L Iturriaga, L Sáenz Del Burgo, I Iloro, M Azkargorta, F Elortza, R Lakshminarayanan, T H Al-Tel, P García-García, R Reyes, A Delgado, C Évora, J L Pedraz, A Dolatshahi-Pirouz, G Orive

Journal: Biomater Adv

PubMed ID: 35513949

Doi: 10.1016/j.msec.2021.112539

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AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

Authors: Hoi Yin Mak, Qian Ouyang, Sergey Tumanov, Jiesi Xu, Ping Rong, Feitong Dong, Sin Man Lam, Xiaowei Wang, Ivan Lukmantara, Ximing Du, Mingming Gao, Andrew J Brown, Xin Gong, Guanghou Shui, Roland Stocker, Xun Huang, Shuai Chen, Hongyuan Yang

Journal: Nat Commun

PubMed ID: 34824276

Doi: 10.1038/s41467-021-27279-4

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Regulation of neuronal excitation-transcription coupling by Kv21-induced clustering of somatic L-type Ca channels at ER-PM junctions

Authors: Nicholas C Vierra, Samantha C O'Dwyer, Collin Matsumoto, L Fernando Santana, James S Trimmer

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34750263

Doi: 10.1073/pnas.2110094118

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Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores

Authors: Dennis J Doorduijn, Dani A C Heesterbeek, Maartje Ruyken, Carla J C de Haas, Daphne A C Stapels, Piet C Aerts, Suzan H M Rooijakkers, Bart W Bardoel

Journal: PLoS Pathog

PubMed ID: 34752492

Doi: 10.1371/journal.ppat.1010051

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Immune signatures underlying post-acute COVID-19 lung sequelae

Authors: I S Cheon, C Li, Y M Son, N P Goplen, Y Wu, T Cassmann, Z Wang, X Wei, J Tang, Y Li, H Marlow, S Hughes, L Hammel, T M Cox, E Goddery, K Ayasoufi, D Weiskopf, J Boonyaratanakornkit, H Dong, H Li, R Chakraborty, A J Johnson, E Edell, J J Taylor, M H Kaplan, A Sette, B J Bartholmai, R Kern, R Vassallo, J Sun

Journal: Sci Immunol

PubMed ID: 34591653

Doi: 10.1126/sciimmunol.abk1741

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Pharmacokinetics of Monoclonal Antibody and Antibody Fragments in the Mouse Eye Following Systemic Administration

Authors: David Bussing, Zhe Li, Yingyi Li, Hsuan-Ping Chang, Hsueh-Yuan Chang, Leiming Guo, Ashwni Verma, Dhaval K Shah

Journal: AAPS J

PubMed ID: 34750690

Doi: 10.1208/s12248-021-00647-0

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Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots

Authors: Jorieke Weiden, Marjolein Schluck, Melina Ioannidis, Eric A W van Dinther, Mahboobeh Rezaeeyazdi, Fawad Omar, Juulke Steuten, Dion Voerman, Jurjen Tel, Mustafa Diken, Sidi A Bencherif, Carl G Figdor, Martijn Verdoes

Journal: ACS Biomater Sci Eng

PubMed ID: 34734689

Doi: 10.1021/acsbiomaterials.0c01648

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Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors

Authors: Samuel Rivero-Hinojosa, Melanie Grant, Aswini Panigrahi, Huizhen Zhang, Veronika Caisova, Catherine M Bollard, Brian R Rood

Journal: Nat Commun

PubMed ID: 34795224

Doi: 10.1038/s41467-021-26936-y

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Humoral immune response following prime and boost BNT162b2 vaccination in people living with HIV on antiretroviral therapy

Authors: Nils Jedicke, Metodi V Stankov, Anne Cossmann, Alexandra Dopfer-Jablonka, Christine Knuth, Gerrit Ahrenstorf, Gema Morillas Ramos, Georg M N Behrens

Journal: HIV Med

PubMed ID: 34725907

Doi: 10.1111/hiv.13202

Co-translational biogenesis of lipid droplet integral membrane proteins

Authors: Pawel Leznicki, Hayden O Schneider, Jada V Harvey, Wei Q Shi, Stephen High

Journal: J Cell Sci

PubMed ID: 34558621

Doi: 10.1242/jcs.259220

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Quench-Release-Based Fluorescent Immunosensor for the Rapid Detection of Tumor Necrosis Factor α

Authors: Haimei Li, Xinyu Li, Limei Chen, Baowei Li, Hang Dong, Hongying Liu, Xueying Yang, Hiroshi Ueda, Jinhua Dong

Journal: ACS Omega

PubMed ID: 34841143

Doi: 10.1021/acsomega.1c03941

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The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila

Authors: Qingliang Sang, Gang Wang, David B Morton, Hui Wu, Baotong Xie

Journal: PLoS Genet

PubMed ID: 34748546

Doi: 10.1371/journal.pgen.1009894

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Zipper head mechanism of telomere synthesis by human telomerase

Authors: Futang Wan, Yongbo Ding, Yuebin Zhang, Zhenfang Wu, Shaobai Li, Lin Yang, Xiangyu Yan, Pengfei Lan, Guohui Li, Jian Wu, Ming Lei

Journal: Cell Res

PubMed ID: 34782750

Doi: 10.1038/s41422-021-00586-7

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Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments

Authors: Karen Yap, Tek Hong Chung, Eugene V Makeyev

Journal: Mol Cell

PubMed ID: 34741808

Doi: 10.1016/j.molcel.2021.10.009

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Increased carvone production in Escherichia coli by balancing limonene conversion enzyme expression via targeted quantification concatamer proteome analysis

Authors: Erika Yoshida, Motoki Kojima, Munenori Suzuki, Fumio Matsuda, Kazutaka Shimbo, Akiko Onuki, Yousuke Nishio, Yoshihiro Usuda, Akihiko Kondo, Jun Ishii

Journal: Sci Rep

PubMed ID: 34764337

Doi: 10.1038/s41598-021-01469-y

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Inhibition of miR-15a-5p Promotes the Chemoresistance to Pirarubicin in Hepatocellular Carcinoma via Targeting eIF4E

Authors: Ying Zhang, Qingsong Tie, Zhiwei Bao, Zhi Shao, Lan Zhang

Journal: Comput Math Methods Med

PubMed ID: 34812269

Doi: 10.1155/2021/6468405

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Characterization of a novel transcript variant: implications for D6D activity regulation in cells

Authors: Kristin A Marks, Maria F Fernandes, Kalsha H Diaguarachchige De Silva, Michelle V Tomczewski, Ken D Stark, Robin E Duncan

Journal: Biochem Cell Biol

PubMed ID: 34738827

Doi: 10.1139/bcb-2020-0538

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HO Functions as a Downstream Signal of IAA to Mediate HS-Induced Chilling Tolerance in Cucumber

Authors: Xiaowei Zhang, Yanyan Zhang, Chenxiao Xu, Kun Liu, Huangai Bi, Xizhen Ai

Journal: Int J Mol Sci

PubMed ID: 34884713

Doi: 10.3390/ijms222312910

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sp nov, isolated from Arctic tundra soil, and emended descriptions of , and

Authors: Yongping Zhang, Xiaoya Peng, Kun Qin, Jia Liu, Qiang Xu, Jingjing Niu, Yanyan Zheng, Fang Peng

Journal: Int J Syst Evol Microbiol

PubMed ID: 34846279

Doi: 10.1099/ijsem.0.005103

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