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页码: 171/1028 每页显示数量

Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family

Authors: Huimin Zhang, Jixiao He, Guang Hu, Fei Zhu, Hao Jiang, Jing Gao, Hu Zhou, Hua Lin, Yingjuan Wang, Kaixian Chen, Fanwang Meng, Minghong Hao, Kehao Zhao, Cheng Luo, Zhongjie Liang

Journal: J Med Chem

PubMed ID: 34668699

Doi: 10.1021/acs.jmedchem.1c01076

Products & Services: Proteins, Expression, Isolation and Analysis

Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

Authors: Shuang-Zhou Peng, Xiao-Hui Chen, Si-Jie Chen, Jie Zhang, Chuan-Ying Wang, Wei-Rong Liu, Duo Zhang, Ying Su, Xiao-Kun Zhang

Journal: Nat Commun

PubMed ID: 34645818

Doi: 10.1038/s41467-021-26295-8

Products & Services: Proteins, Expression, Isolation and Analysis

Evidence of a shared binding site for Bacillus thuringiensis Cry1Ac and Cry2Aa toxins in Cnaphalocrocis medinalis cadherin

Authors: J Zhong, S Fang, M Gao, L Lu, X Zhang, Q Zhu, Y Liu, J L Jurat-Fuentes, X Liu

Journal: Insect Mol Biol

PubMed ID: 34637177

Doi: 10.1111/imb.12741

Products & Services: Proteins, Expression, Isolation and Analysis

Biomaterial-enabled induction of pancreatic-specific regulatory T cells through distinct signal transduction pathways

Authors: Sean T Carey, Joshua M Gammon, Christopher M Jewell

Journal: Drug Deliv Transl Res

PubMed ID: 34611846

Doi: 10.1007/s13346-021-01075-5

Products & Services: Proteins, Expression, Isolation and Analysis

Enemy of My Enemy: A Novel Insect-Specific Flavivirus Offers a Promising Platform for a Zika Virus Vaccine

Authors: Danielle L Porier, Sarah N Wilson, Dawn I Auguste, Andrew Leber, Sheryl Coutermarsh-Ott, Irving C Allen, Clayton C Caswell, James A Budnick, Josep Bassaganya-Riera, Raquel Hontecillas, James Weger-Lucarelli, Scott C Weaver, Albert J Auguste

Journal: Vaccines (Basel)

PubMed ID: 34696250

Doi: 10.3390/vaccines9101142

Products & Services: Plasmid DNA Preparation

L-asparaginase from : expression, purification and cytotoxicity assessment

Authors: Hesham Saeed, Eman Elsawy, Manal Shalaby, Manal Abdel-Fattah, Asmaa Hemida, Ahmad Eldoksh, Farid Shokry Ataya, Hesham Nematalla, Mohamed Elkewedi, Nikolaos N Labrou, Nefertiti El-Nikhely

Journal: Prep Biochem Biotechnol

PubMed ID: 34612174

Doi: 10.1080/10826068.2021.1983831

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Bio-inspired green light crosslinked alginate-heparin hydrogels support HUVEC tube formation

Authors: Patrick N Charron, Luis M Garcia, Irfan Tahir, Rachael A Floreani

Journal: J Mech Behav Biomed Mater

PubMed ID: 34736027

Doi: 10.1016/j.jmbbm.2021.104932

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A Novel Antimicrobial Peptide Sparamosin From the Mud Crab Showing Potent Antifungal Activity Against

Authors: Yan-Chao Chen, Ying Yang, Chang Zhang, Hui-Yun Chen, Fangyi Chen, Ke-Jian Wang

Journal: Front Microbiol

PubMed ID: 34690992

Doi: 10.3389/fmicb.2021.746006

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Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers

Authors: Xueyin Wang, Mark L Sandberg, Aaron D Martin, Kathleen R Negri, Grant B Gabrelow, Daniel P Nampe, Ming-Lun Wu, Michele E McElvain, Dora Toledo Warshaviak, Wen-Hua Lee, Julyun Oh, Mark E Daris, Falene Chai, Christine Yao, James Furney, Craig Pigott, Alexander Kamb, Han Xu

Journal: J Immunother

PubMed ID: 34432728

Doi: 10.1097/CJI.0000000000000386

Products & Services: Peptide Synthesis

Marked Increase in Tumor Transfection with a Truncated Branched Polymer

Authors: Songhui Xu, Jiaxi He, Zuha Imtiyaz, Atul K Agrawal, Martin C Woodle, A James Mixson

Journal: J Gene Med

PubMed ID: 34713552

Doi: 10.1002/jgm.3396

Products & Services: Peptide Synthesis

Binding of de novo synthesized radiolabeled juvenile hormone (JH III) by JH receptors from the Cuban subterranean termite Prorhinotermes simplex and the German cockroach Blattella germanica

Authors: Matej Milacek, Lenka Bittova, Sarka Tumova, Ondrej Luksan, Robert Hanus, Pavlina Kyjakova, Ales Machara, Ales Marek, Marek Jindra

Journal: Insect Biochem Mol Biol

PubMed ID: 34656795

Doi: 10.1016/j.ibmb.2021.103671

Products & Services: Codon Optimization

Engineering transcriptional regulation in Escherichia coli using an archaeal TetR-family transcription factor

Authors: David Sybers, Amber Joka Bernauw, Diala El Masri, Hassan Ramadan Maklad, Daniel Charlier, Marjan De Mey, Indra Bervoets, Eveline Peeters

Journal: Gene

PubMed ID: 34688814

Doi: 10.1016/j.gene.2021.146010

Products & Services: Codon Optimization

Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8 T-Cell Responses

Authors: Xuedan He, Shiqi Zhou, Breandan Quinn, Wei-Chiao Huang, Dushyant Jahagirdar, Michael Vega, Joaquin Ortega, Mark D Long, Fumito Ito, Scott I Abrams, Jonathan F Lovell

Journal: Adv Sci (Weinh)

PubMed ID: 34716694

Doi: 10.1002/advs.202103023

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Tuning Gene Expression by Phosphate in the Methanogenic Archaeon

Authors: Taiwo S Akinyemi, Nana Shao, Zhe Lyu, Ian J Drake, Yuchen Liu, William B Whitman

Journal: ACS Synth Biol

PubMed ID: 34665610

Doi: 10.1021/acssynbio.1c00322

Products & Services: Bacterial Expression

An Engineered Thermostable Laccase with Great Ability to Decolorize and Detoxify Malachite Green

Authors: Guotao Mao, Kai Wang, Fangyuan Wang, Hao Li, Hongsen Zhang, Hui Xie, Zhimin Wang, Fengqin Wang, Andong Song

Journal: Int J Mol Sci

PubMed ID: 34769185

Doi: 10.3390/ijms222111755

Products & Services: Gene Synthesis

Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain

Authors: Mei Yang, Jiaqi Li, Zhaoxia Huang, Heng Li, Yueming Wang, Xiaoli Wang, Sisi Kang, Xing Huang, Changwen Wu, Tong Liu, Zhenxing Jia, Junlang Liang, Xiaohui Yuan, Suhua He, Xiaoxue Chen, Zhechong Zhou, Qiuyue Chen, Siqi Liu, Jing Li, Huiwen Zheng, Xi Liu, Kenan Li, Xiaojun Yao, Bin Lang, Longding Liu, Hua-Xin Liao, Shoudeng Chen

Journal: Microbiol Spectr

PubMed ID: 34643438

Doi: 10.1128/Spectrum.01352-21

Products & Services: Recombinant Proteins

Flexible linker modulates the binding affinity of the TP901-1 CI phage repressor to DNA

Authors: Anders Kokkenborg Varming, Kim Krighaar Rasmussen, Zhiyou Zong, Peter Waaben Thulstrup, Mogens Kilstrup, Leila Lo Leggio

Journal: FEBS J

PubMed ID: 34665941

Doi: 10.1111/febs.16238

Products & Services: Recombinant Proteins

Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative Colitis Inhibition of AOC

Authors: Yumei Rong, Ge Hong, Na Zhu, Yang Liu, Yong Jiang, Tianjun Liu

Journal: Front Pharmacol

PubMed ID: 34744725

Doi: 10.3389/fphar.2021.746725

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Human antibody recognition of H7N9 influenza virus HA following natural infection

Authors: Iuliia M Gilchuk, Sandhya Bangaru, Nurgun Kose, Robin G Bombardi, Andrew Trivette, Sheng Li, Hannah L Turner, Robert H Carnahan, Andrew B Ward, James E Crowe

Journal: JCI Insight

PubMed ID: 34437301

Doi: 10.1172/jci.insight.152403

Products & Services: Gene Synthesis

Molecular Characterization of AMPA-Receptor-Containing Vesicles

Authors: John Jacob Peters, Jeremy Leitz, Juan A Oses-Prieto, Alma L Burlingame, Axel T Brunger

Journal: Front Mol Neurosci

PubMed ID: 34720876

Doi: 10.3389/fnmol.2021.754631

Products & Services: Peptide Synthesis

Inhibition of receptor-binding domain-ACE2 interaction after two doses of Sinovac's CoronaVac or AstraZeneca/Oxford's AZD1222 SARS-CoV-2 vaccines

Authors: Valéria O Silva, Rosemeire Yamashiro, Cintia M Ahagon, Ivana B de Campos, Isabela P de Oliveira, Elaine L de Oliveira, Giselle I S López-Lopes, Elaine M Matsuda, Marcia J Castejon, Luís F de Macedo Brígido

Journal: J Med Virol

PubMed ID: 34647623

Doi: 10.1002/jmv.27396

Products & Services: Serology SARS-Cov-2 detection kits

Oncogenic KIT Induces Replication stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma

Authors: Ching-Ni Njauw, Zhenyu Ji, Duc Minh Pham, Antoine Simoneau, Raj Kumar, Keith T Flaherty, Lee Zou, Hensin Tsao

Journal: J Invest Dermatol

PubMed ID: 34687746

Doi: 10.1016/j.jid.2021.07.188

Products & Services: Gene Synthesis

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Authors: Thushan I de Silva, Guihai Liu, Benjamin B Lindsey, Danning Dong, Shona C Moore, Nienyun Sharon Hsu, Dhruv Shah, Dannielle Wellington, Alexander J Mentzer, Adrienn Angyal, Rebecca Brown, Matthew D Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, Mala K Maini, Graham Ogg, Julian C Knight, Yanchun Peng, Sarah L Rowland-Jones, Tao Dong

Journal: iScience

PubMed ID: 34729465

Doi: 10.1016/j.isci.2021.103353

Products & Services: Peptide Synthesis

miR-301a-5p Regulates during Chicken Spermatogenesis

Authors: Qixin Guo, Yong Jiang, Hao Bai, Guohong Chen, Guobin Chang

Journal: Genes (Basel)

PubMed ID: 34828300

Doi: 10.3390/genes12111695

Products & Services: Custom DNA/RNA Oligos

Bright and stable luminescent probes for target engagement profiling in live cells

Authors: N Connor Payne, Alena S Kalyakina, Kritika Singh, Mark A Tye, Ralph Mazitschek

Journal: Nat Chem Biol

PubMed ID: 34675420

Doi: 10.1038/s41589-021-00877-5

Products & Services: Plasmid DNA Preparation

Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle-Based Small Interfering RNA

Authors: Xin Duan, Lei Cai, Christine T N Pham, Yousef Abu-Amer, Hua Pan, Robert H Brophy, Samuel A Wickline, Muhammad Farooq Rai

Journal: Arthritis Rheumatol

PubMed ID: 33982891

Doi: 10.1002/art.41794

Products & Services: Catalog Peptides

Biophysical Characterization of Iron-Sulfur Proteins

Authors: Bhanu P Jagilinki, Irina Paluy, Alexei M Tyryshkin, Vikas Nanda, Dror Noy

Journal: Bio Protoc

PubMed ID: 34761074

Doi: 10.21769/BioProtoc.4202

Products & Services: Plasmid DNA Preparation

Serological response to mRNA and inactivated COVID-19 vaccine in healthcare workers in Hong Kong: decline in antibodies 12 weeks after two doses

Authors: J S T Zee, K T W Lai, M K S Ho, A C P Leung, L H Fung, W P Luk, L F Kwok, K M Kee, Q W L Chan, S F Tang, E S K Ma, K H Lee, C C Lau, R W H Yung

Journal: Hong Kong Med J

PubMed ID: 34657837

Doi: 10.12809/hkmj219744

Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases

Authors: Xiaojie Chu, Zehua Sun, Du-San Baek, Wei Li, John W Mellors, Steven D Shapiro, Dimiter S Dimitrov

Journal: Int J Mol Sci

PubMed ID: 34681796

Doi: 10.3390/ijms222011136

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A New Hybrid Protein Is a Novel Regulator for Experimental Colitis in Rats

Authors: Kohki Okada, Masaki Ikemoto

Journal: Inflammation

PubMed ID: 34628574

Doi: 10.1007/s10753-021-01537-5

Products & Services: Proteins, Expression, Isolation and Analysis

Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency

Authors: Hsi-En Ho, Lin Radigan, Gerold Bongers, Ahmed El-Shamy, Charlotte Cunningham-Rundles

Journal: JCI Insight

PubMed ID: 34622805

Doi: 10.1172/jci.insight.144777

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Self-inhibitory peptides targeting the MtrCDE efflux pump increase antibiotic susceptibility

Authors: Benjamin J Evert, Valentin A Slesarenko, Jilsy M J Punnasseril, Jian Zhan, Yaoqi Zhou, Evgeny A Semchenko, Kate L Seib

Journal: Antimicrob Agents Chemother

PubMed ID: 34633841

Doi: 10.1128/AAC.01542-21

Products & Services: Peptide Synthesis

8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules

Authors: Tamás Pivarcsik, Orsolya Dömötör, János P Mészáros, Nóra V May, Gabriella Spengler, Oszkár Csuvik, István Szatmári, Éva A Enyedy

Journal: Int J Mol Sci

PubMed ID: 34681939

Doi: 10.3390/ijms222011281

Products & Services: Gene Synthesis

High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1

Authors: Anja Bernhardt, Saskia Häberer, JingJing Xu, Hannah Damerau, Johannes Steffen, Charlotte Reichardt, Katharina Wolters, Hannes Steffen, Berend Isermann, Katrin Borucki, Nadine Artelt, Nicole Endlich, Renata Kozyraki, Sabine Brandt, Jonathan A Lindquist, Peter R Mertens

Journal: FASEB J

PubMed ID: 34533842

Doi: 10.1096/fj.202100667RR

Products & Services: Proteins, Expression, Isolation and Analysis

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

Authors: Vlad Petrovan, Anusyah Rathakrishnan, Muneeb Islam, Lynnette C Goatley, Katy Moffat, Pedro J Sanchez-Cordon, Ana L Reis, Linda K Dixon

Journal: J Virol

PubMed ID: 34643433

Doi: 10.1128/JVI.01340-21

Products & Services: Plasmid DNA Preparation

A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates

Authors: Chang Guo, Yanan Peng, Lin Lin, Xiaoyan Pan, Mengqi Fang, Yun Zhao, Keyan Bao, Runhan Li, Jianbao Han, Jiaorong Chen, Tian-Zhang Song, Xiao-Li Feng, Yahong Zhou, Gan Zhao, Leike Zhang, Yongtang Zheng, Ping Zhu, Haiying Hang, Linqi Zhang, Zhaolin Hua, Hongyu Deng, Baidong Hou

Journal: Cell Rep Med

PubMed ID: 34723223

Doi: 10.1016/j.xcrm.2021.100448

Products & Services: Proteins, Expression, Isolation and Analysis

Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells

Authors: Ying Zhou, Shuhong Zhang, Zhonghan Min, Zhongwei Yu, Huaiwei Zhang, Jiao Jiao

Journal: BMC Cancer

PubMed ID: 34620126

Doi: 10.1186/s12885-021-08779-4

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Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile

Authors: Jeba R J Jesudoss Chelladurai, Douglas E Jones, Matthew T Brewer

Journal: Int J Parasitol Drugs Drug Resist

PubMed ID: 34753107

Doi: 10.1016/j.ijpddr.2021.10.002

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Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

Authors: Xia Bu, Vikram R Juneja, Carol G Reynolds, Kathleen M Mahoney, Melissa T Bu, Kathleen A McGuire, Seth Maleri, Ping Hua, Baogong Zhu, Sarah R Klein, Edward A Greenfield, Philippe Armand, Jerome Ritz, Arlene H Sharpe, Gordon J Freeman

Journal: Cancer Immunol Res

PubMed ID: 34635486

Doi: 10.1158/2326-6066.CIR-21-0493

Products & Services: Peptide Synthesis

Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspective

Authors: Jeremy Baldwin, Sakshi Piplani, Isaac G Sakala, Yoshikazu Honda-Okubo, Lei Li, Nikolai Petrovsky

Journal: Bioanalysis

PubMed ID: 34645288

Doi: 10.4155/bio-2021-0096

Products & Services: Recombinant Proteins

Erratum: Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

Authors:

Journal: Front Pharmacol

PubMed ID: 34744755

Doi: 10.3389/fphar.2021.788046

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Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold

Authors: Anjana Kaveri Badekila, Praveen Rai, Sudarshan Kini

Journal: Mol Biol Rep

PubMed ID: 34665400

Doi: 10.1007/s11033-021-06830-y

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Design of a chitosan-based nano vaccine against epsilon toxin of type D and evaluation of its immunogenicity in BALB/c mice

Authors: Farnaz Poorhassan, Fahimeh Nemati, Parvaneh Saffarian, Seyed Ali Mirhosseini, Mohammad Javad Motamedi

Journal: Res Pharm Sci

PubMed ID: 34760006

Doi: 10.4103/1735-5362.327504

Products & Services: Bacterial Expression

Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro

Authors: Masanori Tsubosaka, Masahiro Maruyama, Elijah Ejun Huang, Ning Zhang, Takeshi Utsunomiya, Qi Gao, Huaishuang Shen, Xueping Li, Junichi Kushioka, Hirohito Hirata, Zhenyu Yao, Yunzhi Peter Yang, Stuart B Goodman

Journal: Bioengineering (Basel)

PubMed ID: 34821731

Doi: 10.3390/bioengineering8110165

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Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems

Authors: Virginia Hill, Hatice Akarsu, Rubén Sánchez Barbarroja, Valentina L Cippà, Peter Kuhnert, Martin Heller, Laurent Falquet, Manfred Heller, Michael H Stoffel, Fabien Labroussaa, Joerg Jores

Journal: PLoS Genet

PubMed ID: 34673769

Doi: 10.1371/journal.pgen.1009365

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Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects

Authors: Sabrina Lusvarghi, Wei Wang, Rachel Herrup, Sabari Nath Neerukonda, Russell Vassell, Lisa Bentley, Ann E Eakin, Karl J Erlandson, Carol D Weiss

Journal: J Virol

PubMed ID: 34668774

Doi: 10.1128/JVI.01110-21

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The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains

Authors: Jocelyn D Weissman, Amit K Singh, Ballachanda N Devaiah, Peter Schuck, Ross C LaRue, Dinah S Singer

Journal: J Biol Chem

PubMed ID: 34688663

Doi: 10.1016/j.jbc.2021.101326

Products & Services: Proteins, Expression, Isolation and Analysis

The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization

Authors: Anna Schorcht, Christopher A Cottrell, Pavel Pugach, Rajesh P Ringe, Alvin X Han, Joel D Allen, Tom L G M van den Kerkhof, Gemma E Seabright, Edith E Schermer, Thomas J Ketas, Judith A Burger, Jelle van Schooten, Celia C LaBranche, Gabriel Ozorowski, Natalia de Val, Daniel L V Bader, Hanneke Schuitemaker, Colin A Russell, David C Montefiori, Marit J van Gils, Max Crispin, P J Klasse, Andrew B Ward, John P Moore, Rogier W Sanders

Journal: J Virol

PubMed ID: 34669426

Doi: 10.1128/JVI.01552-21

Products & Services: Codon Optimization

Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein

Authors: Chao Wu, Abraham J Qavi, Austin B Moyle, Nicole D Wagner, Asmaa Hachim, Niloufar Kavian, Aidan R Cole, Joyce Sweeney-Gibbons, Henry W Rohrs, J S Malik Peiris, Christopher F Basler, Michael L Gross, Sophie A Valkenburg, Christopher W Farnsworth, Gaya K Amarasinghe, Daisy W Leung

Journal: STAR Protoc

PubMed ID: 34642671

Doi: 10.1016/j.xpro.2021.100906

Products & Services: Gene Synthesis

Protective effect of sargahydroquinoic acid against Aβ-evoked damage via PI3K/Akt mediated Nrf2 antioxidant defense system

Authors: Jeong-Hyun Yoon, Kumju Youn, Mira Jun

Journal: Biomed Pharmacother

PubMed ID: 34619494

Doi: 10.1016/j.biopha.2021.112271

Products & Services: Proteins, Expression, Isolation and Analysis

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