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Tandem mass tag (TMT)-based proteomic analysis of Cryptosporidium andersoni oocysts before and after excystation

Authors: Dong-Fang Li, Zhao-Hui Cui, Lu-Yang Wang, Kai-Hui Zhang, Le-Tian Cao, Shuang-Jian Zheng, Long-Xian Zhang

Journal: Parasit Vectors

PubMed ID: 34922597

Doi: 10.1186/s13071-021-05113-6

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Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors

Authors: Ru Dong, Cheng Zhang, Chao Wang, Xin Zhou, Wen Li, Jin-Yang Zhang, Min Wang, Yong Xu, Li-Ping Sun

Journal: Bioorg Med Chem

PubMed ID: 34999525

Doi: 10.1016/j.bmc.2021.116592

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Author Correction: Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro

Authors: Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde

Journal: Commun Biol

PubMed ID: 34893762

Doi: 10.1038/s42003-021-02940-2

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SlpB Protein Enhances the Probiotic Potential of NCDO 2118 in Colitis Mice Model

Authors: Giovanna A Belo, Bárbara F Cordeiro, Emiliano R Oliveira, Marina P Braga, Sara H da Silva, Bruno G Costa, Flaviano Dos S Martins, Gwénaël Jan, Yves Le Loir, Alfonso Gala-García, Enio Ferreira, Vasco Azevedo, Fillipe L R do Carmo

Journal: Front Pharmacol

PubMed ID: 34987390

Doi: 10.3389/fphar.2021.755825

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Immunization with short peptide particles reveals a functional CD8 T-cell neoepitope in a murine renal carcinoma model

Authors: Xuedan He, Shiqi Zhou, Melissa Dolan, Yuhao Shi, Jianxin Wang, Breandan Quinn, Dushyant Jahagirdar, Wei-Chiao Huang, Moriya Tsuji, Roberto Pili, Fumito Ito, Joaquin Ortega, Scott I Abrams, John M L Ebos, Jonathan F Lovell

Journal: J Immunother Cancer

PubMed ID: 34862254

Doi: 10.1136/jitc-2021-003101

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Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants

Authors: Wei-Shuo Lin, I-Chen Chen, Hui-Chen Chen, Yi-Chien Lee, Suh-Chin Wu

Journal: Front Immunol

PubMed ID: 34925381

Doi: 10.3389/fimmu.2021.795741

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Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis of Proteins

Authors: Clara L Kielkopf, William Bauer, Ina L Urbatsch

Journal: Cold Spring Harb Protoc

PubMed ID: 34853120

Doi: 10.1101/pdb.prot102228

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CFAP61 is required for sperm flagellum formation and male fertility in human and mouse

Authors: Siyu Liu, Jintao Zhang, Zine Eddine Kherraf, Shuya Sun, Xin Zhang, Caroline Cazin, Charles Coutton, Raoudha Zouari, Shuqin Zhao, Fan Hu, Selima Fourati Ben Mustapha, Christophe Arnoult, Pierre F Ray, Mingxi Liu

Journal: Development

PubMed ID: 34792097

Doi: 10.1242/dev.199805

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Phylogeny of Leptographium qinlingensis cytochrome P450 genes and transcription levels of six CYPs in response to different nutrition media or terpenoids

Authors: Lulu Dai, Jie Zheng, Jiaqi Ye, Hui Chen

Journal: Arch Microbiol

PubMed ID: 34894279

Doi: 10.1007/s00203-021-02616-9

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De novo design of a transcription factor for a progesterone biosensor

Authors: Kun Liu, Yunsen Zhang, Ke Liu, Yunqiu Zhao, Bei Gao, Xinyi Tao, Ming Zhao, Feng-Qing Wang, Dongzhi Wei

Journal: Biosens Bioelectron

PubMed ID: 35134684

Doi: 10.1016/j.bios.2021.113897

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Inflammatory macrophages exploit unconventional pro-phagocytic integrins for phagocytosis and anti-tumor immunity

Authors: Zhenghai Tang, Dominique Davidson, Rui Li, Ming-Chao Zhong, Jin Qian, Jun Chen, André Veillette

Journal: Cell Rep

PubMed ID: 34910922

Doi: 10.1016/j.celrep.2021.110111

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The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway

Authors: Ping Zhang, Zhiqiang Cui, Shuai Li

Journal: Bioengineered

PubMed ID: 34605740

Doi: 10.1080/21655979.2021.1979914

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Cabergoline possesses a beneficial effect on blood-brain barrier (BBB) integrity against lipopolysaccharide (LPS)

Authors: Lina You, Haidong Jiang

Journal: Bioengineered

PubMed ID: 34592907

Doi: 10.1080/21655979.2021.1987066

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ER proteins decipher the tubulin code to regulate organelle distribution

Authors: Pengli Zheng, Christopher J Obara, Ewa Szczesna, Jonathon Nixon-Abell, Kishore K Mahalingan, Antonina Roll-Mecak, Jennifer Lippincott-Schwartz, Craig Blackstone

Journal: Nature

PubMed ID: 34912111

Doi: 10.1038/s41586-021-04204-9

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Multiplexed CRISPR-mediated engineering of protein secretory pathway genes in the thermotolerant methylotrophic yeast Ogataea thermomethanolica

Authors: Worarat Kruasuwan, Aekkachai Puseenam, Sutipa Tanapongpipat, Niran Roongsawang

Journal: PLoS ONE

PubMed ID: 34941944

Doi: 10.1371/journal.pone.0261754

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Cell Surface SARS-CoV-2 Nucleocapsid Protein Modulates Innate and Adaptive Immunity

Authors: Alberto Domingo López-Muñoz, Ivan Kosik, Jaroslav Holly, Jonathan W Yewdell

Journal: biorxiv

PubMed ID: 34931195

Doi: 10.1101/2021.12.10.472169

Products & Services: Mammalian Expression

A single-nucleotide mutation within the TBX3 enhancer increased body size in Chinese horses

Authors: Xuexue Liu, Yanli Zhang, Wujun Liu, Yefang Li, Jianfei Pan, Yabin Pu, Jianlin Han, Ludovic Orlando, Yuehui Ma, Lin Jiang

Journal: Curr Biol

PubMed ID: 34906355

Doi: 10.1016/j.cub.2021.11.052

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Kinetic Characterization of Human Histone Deacetylase 8 With Medium-Chain Fatty Acyl Lysine

Authors: Harrison Yoo, Gregory A Polsinelli

Journal: Epigenet Insights

PubMed ID: 34917889

Doi: 10.1177/25168657211065685

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SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

Authors: Meng-Li Wu, Feng-Liang Liu, Jing Sun, Xin Li, Xiao-Yan He, Hong-Yi Zheng, Yan-Heng Zhou, Qihong Yan, Ling Chen, Guo-Ying Yu, Junbiao Chang, Xia Jin, Jincun Zhao, Xin-Wen Chen, Yong-Tang Zheng, Jian-Hua Wang

Journal: Signal Transduct Target Ther

PubMed ID: 34921131

Doi: 10.1038/s41392-021-00849-0

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Effect of human secretory calcium-binding phosphoprotein proline-glutamine rich 1 protein on Porphyromonas gingivalis and identification of its active portions

Authors: Charline Mary, Aurélien Fouillen, Pierre Moffatt, Dainelys Guadarrama Bello, Rima M Wazen, Daniel Grenier, Antonio Nanci

Journal: Sci Rep

PubMed ID: 34887426

Doi: 10.1038/s41598-021-02661-w

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KRas-transformed epithelia cells invade and partially dedifferentiate by basal cell extrusion

Authors: John Fadul, Teresa Zulueta-Coarasa, Gloria M Slattum, Nadja M Redd, Mauricio Franco Jin, Michael J Redd, Stephan Daetwyler, Danielle Hedeen, Jan Huisken, Jody Rosenblatt

Journal: Nat Commun

PubMed ID: 34893591

Doi: 10.1038/s41467-021-27513-z

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RGEN-seq for highly sensitive amplification-free screen of off-target sites of gene editors

Authors: Alexander Kuzin, Brendan Redler, Jaya Onuska, Alexei Slesarev

Journal: Sci Rep

PubMed ID: 34880355

Doi: 10.1038/s41598-021-03160-8

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Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

Authors: Jian Chen, Jun Fan, Zhilu Chen, Miaomiao Zhang, Haoran Peng, Jian Liu, Longfei Ding, Mingbin Liu, Chen Zhao, Ping Zhao, Shuye Zhang, Xiaoyan Zhang, Jianqing Xu

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34873039

Doi: 10.1073/pnas.2111011118

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Structure, mechanism, and inhibition of Hedgehog acyltransferase

Authors: Claire E Coupland, Sebastian A Andrei, T Bertie Ansell, Loic Carrique, Pramod Kumar, Lea Sefer, Rebekka A Schwab, Eamon F X Byrne, Els Pardon, Jan Steyaert, Anthony I Magee, Thomas Lanyon-Hogg, Mark S P Sansom, Edward W Tate, Christian Siebold

Journal: Mol Cell

PubMed ID: 34890564

Doi: 10.1016/j.molcel.2021.11.018

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African Swine Fever Virus cysteine protease pS273R Inhibits Pyroptosis by Non-canonically Cleaving Gasdermin D

Authors: Gaihong Zhao, Tingting Li, Xuemin Liu, Taoqing Zhang, Zhaoxia Zhang, Li Kang, Jie Song, Shijun Zhou, Xin Chen, Xiao Wang, Jiangnan Li, Li Huang, Changyao Li, Zhigao Bu, Jun Zheng, Changjiang Weng

Journal: J Biol Chem

PubMed ID: 34890644

Doi: 10.1016/j.jbc.2021.101480

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MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge

Authors: Clement A Meseda, Charles B Stauft, Prabhuanand Selvaraj, Christopher Z Lien, Cyntia Pedro, Ivette A Nuñez, Amy M Woerner, Tony T Wang, Jerry P Weir

Journal: npj Vaccines

PubMed ID: 34862398

Doi: 10.1038/s41541-021-00410-8

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Analysis of CcGASA family members in Citrus clementina (Hort ex Tan) by a genome-wide approach

Authors: Tianli Wu, Yun Zhong, Min Chen, Bo Wu, Ting Wang, Bo Jiang, Guangyan Zhong

Journal: BMC Plant Biol

PubMed ID: 34852791

Doi: 10.1186/s12870-021-03326-6

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The microtubule-associated protein She1 coordinates directional spindle positioning by spatially restricting dynein activity

Authors: Kari H Ecklund, Megan E Bailey, Kelly A Kossen, Carsten K Dietvorst, Charles L Asbury, Steven M Markus

Journal: J Cell Sci

PubMed ID: 34854468

Doi: 10.1242/jcs.258510

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Cloning and Characterization of Two Putative P-Type ATPases from the Marine Microalga Similar to Plant H-ATPases and Their Gene Expression Analysis under Conditions of Hyperosmotic Salt Shock

Authors: Dmitrii A Matalin, Dmitrii E Khramov, Alexey V Shuvalov, Vadim S Volkov, Yurii V Balnokin, Larissa G Popova

Journal: Plants (Basel)

PubMed ID: 34961138

Doi: 10.3390/plants10122667

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Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion

Authors: Yifan Ge, Sivakumar Boopathy, Tran H Nguyen, Camila Makhlouta Lugo, Luke H Chao

Journal: Front Mol Biosci

PubMed ID: 35004847

Doi: 10.3389/fmolb.2021.769135

Products & Services: Mammalian Expression

MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1

Authors: Yan Li, Nianling Yao, Yan Gao, Yunping Wang, Lu Bai, Jia Xu, Haixu Wang

Journal: Bioengineered

PubMed ID: 34637688

Doi: 10.1080/21655979.2021.1987125

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Genome-wide identification and expression analysis of ammonium transporter 1 (AMT1) gene family in cassava ( Crantz) and functional analysis of in transgenic

Authors: Youquan Xia, Yindi Liu, Tingting Zhang, Yu Wang, Xingyu Jiang, Yang Zhou

Journal: 3 Biotech

PubMed ID: 34926117

Doi: 10.1007/s13205-021-03070-6

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Structural insights into Ubr1-mediated N-degron polyubiquitination

Authors: Man Pan, Qingyun Zheng, Tian Wang, Lujun Liang, Junxiong Mao, Chong Zuo, Ruichao Ding, Huasong Ai, Yuan Xie, Dong Si, Yuanyuan Yu, Lei Liu, Minglei Zhao

Journal: Nature.

PubMed ID: 34789879

Doi: 10.1038/s41586-021-04097-8

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EasyCatch, a convenient, sensitive and specific CRISPR detection system for cancer gene mutations

Authors: Yin Liu, Yanling Chen, Lu Dang, Yixin Liu, Shisheng Huang, Sanyun Wu, Peixiang Ma, Hongqiang Jiang, Yi Li, Yunbao Pan, Yongchang Wei, Xiaodong Ma, Ming Liu, Quanjiang Ji, Tian Chi, Xingxu Huang, Xinjie Wang, Fuling Zhou

Journal: Mol Cancer

PubMed ID: 34856977

Doi: 10.1186/s12943-021-01456-x

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Prevotella copri ameliorates cholestasis and liver fibrosis in primary sclerosing cholangitis by enhancing the FXR signalling pathway

Authors: Baorong Jiang, Gehui Yuan, Jialin Wu, Qian Wu, Lei Li, Ping Jiang

Journal: Biochim Biophys Acta Mol Basis Dis

Doi: 10.1016/j.bbadis.2021.166320

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Zafirlukast ameliorates Docetaxel-induced activation of NOD-like receptor protein 3 (NLRP3) inflammasome, mediated by sirtuin1 (SIRT1) in hepatocytes

Authors: Ziyi Guo, Xunjin Zeng, Yu Zheng

Journal: Bioengineered

PubMed ID: 34787067

Doi: 10.1080/21655979.2021.2005895

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Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/ axis

Authors: Xiaohui Lu, Haijie Gao, Bo Zhu, Guilan Lin

Journal: Bioengineered

PubMed ID: 34546853

Doi: 10.1080/21655979.2021.1964157

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The Retropepsin-Type Protease APRc as a Novel Ig-Binding Protein and Moonlighting Immune Evasion Factor of

Authors: Pedro Curto, Andreia Barro, Carla Almeida, Ricardo S Vieira-Pires, Isaura Simões

Journal: MBio

PubMed ID: 34872352

Doi: 10.1128/mBio.03059-21

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The WalR-WalK signaling pathway modulates the activities of both CwlO and LytE through control of the peptidoglycan deacetylase PdaC in

Authors: Genevieve S Dobihal, Josué Flores-Kim, Ian J Roney, Xindan Wang, David Z Rudner

Journal: J Bacteriol

PubMed ID: 34871030

Doi: 10.1128/JB.00533-21

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Cas9-Based Local Enrichment and Genomics Sequence Revision of Megabase-Sized Shark IgNAR Loci

Authors: Hongming Dong, Yaolei Zhang, Jiahao Wang, Haitao Xiang, Tianhang Lv, Likun Wei, Shaosen Yang, Xiaopan Liu, Bingzhao Ren, Xiuqing Zhang, Lirong Liu, Jun Cao, Meiniang Wang, Jiahai Shi, Naibo Yang

Journal: J Immunol

PubMed ID: 34880108

Doi: 10.4049/jimmunol.2100844

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Immuno-biosensor on a chip: a self-powered microfluidic-based electrochemical biosensing platform for point-of-care quantification of proteins

Authors: Fatemeh Haghayegh, Razieh Salahandish, Azam Zare, Mahmood Khalghollah, Amir Sanati-Nezhad

Journal: Lab Chip

PubMed ID: 34860233

Doi: 10.1039/d1lc00879j

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Aquaporin family lactic acid channel NIP2;1 promotes plant survival under low oxygen stress in Arabidopsis

Authors: Zachary G Beamer, Pratyush Routray, Won-Gyu Choi, Margaret K Spangler, Ansul Lokdarshi, Daniel M Roberts

Journal: Plant Physiol

PubMed ID: 34890456

Doi: 10.1093/plphys/kiab196

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Immunogenicity and safety of two doses of the CoronaVac SARS-CoV-2 vaccine in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic diseases in Brazil: a subgroup analysis of a phase 4 prospective study

Authors: Nadia E Aikawa, Leonard V K Kupa, Sandra G Pasoto, Ana C Medeiros-Ribeiro, Emily F N Yuki, Carla G S Saad, Tatiana Pedrosa, Ricardo Fuller, Samuel K Shinjo, Percival D Sampaio-Barros, Danieli C O Andrade, Rosa M R Pereira, Luciana P C Seguro, Juliana M L Valim, Filipe Waridel, Ana Marli C Sartori, Alberto J S Duarte, Leila Antonangelo, Ester C Sabino, Paulo Rossi Menezes, Esper G Kallas, Clovis A Silva, Eloisa Bonfa

Journal: Lancet Rheumatol

PubMed ID: 34901885

Doi: 10.1016/S2665-9913(21)00327-1

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Cleavage-Free Human Genome Editing

Authors: Chenzhong Kuang, Yan Xiao, Dirk Hondmann

Journal: Mol Ther

PubMed ID: 34864205

Doi: 10.1016/j.ymthe.2021.12.001

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Aquaporin expression and cholesterol content in eel swimbladder tissue

Authors: Victoria Drechsel, Gabriel Schneebauer, Birgit Fiechtner, Christopher P Cutler, Bernd Pelster

Journal: J Fish Biol

PubMed ID: 34882794

Doi: 10.1111/jfb.14973

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Novel Variations in the Gene Causing X-Linked Intellectual Disability

Authors: Po-Ming Wu, Wen-Hao Yu, Chi-Wu Chiang, Chen-Yu Wu, Jia-Shing Chen, Yi-Fang Tu

Journal: Neurol Genet

PubMed ID: 34877407

Doi: 10.1212/NXG.0000000000000646

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FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism

Authors: Wenlu Fan, Xiaoye Jin, Man Xu, Yongmei Xi, Weiguo Lu, Xiaohang Yang, Min-Xin Guan, Wanzhong Ge

Journal: Nucleic Acids Res

PubMed ID: 34878141

Doi: 10.1093/nar/gkab1187

Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis

Authors: Brandon M Lane, Megan Chryst-Stangl, Guanghong Wu, Mohamed Shalaby, Sherif El Desoky, Claire C Middleton, Kinsie Huggins, Amika Sood, Alejandro Ochoa, Andrew F Malone, Ricardo Vancini, Sara E Miller, Gentzon Hall, So Young Kim, David N Howell, Jameela A Kari, Rasheed Gbadegesin

Journal: JCI Insight

PubMed ID: 34874915

Doi: 10.1172/jci.insight.152102

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ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit

Authors: Anaïs Lamy, Ewerton Macarini-Bruzaferro, Thibaud Dieudonné, Alex Perálvarez-Marín, Guillaume Lenoir, Cédric Montigny, Marc le Maire, José Luis Vázquez-Ibar

Journal: Emerg Microbes Infect

PubMed ID: 33372863

Doi: 10.1080/22221751.2020.1870413

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Antibody response to second dose of the BNT162b2 mRNA vaccine in the first 12 weeks in South Korea: A prospective longitudinal study

Authors: Hyun Jin Kim, Heon Jeong Yun, Jungok Kim, Sungmin Kym, Qute Choi

Journal: Vaccine

PubMed ID: 34953606

Doi: 10.1016/j.vaccine.2021.12.012

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