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页码: 170/1027 每页显示数量

Oncogenic KIT Induces Replication stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma

Authors: Ching-Ni Njauw, Zhenyu Ji, Duc Minh Pham, Antoine Simoneau, Raj Kumar, Keith T Flaherty, Lee Zou, Hensin Tsao

Journal: J Invest Dermatol

PubMed ID: 34687746

Doi: 10.1016/j.jid.2021.07.188

Products & Services: Gene Synthesis

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Authors: Thushan I de Silva, Guihai Liu, Benjamin B Lindsey, Danning Dong, Shona C Moore, Nienyun Sharon Hsu, Dhruv Shah, Dannielle Wellington, Alexander J Mentzer, Adrienn Angyal, Rebecca Brown, Matthew D Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, Mala K Maini, Graham Ogg, Julian C Knight, Yanchun Peng, Sarah L Rowland-Jones, Tao Dong

Journal: iScience

PubMed ID: 34729465

Doi: 10.1016/j.isci.2021.103353

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miR-301a-5p Regulates during Chicken Spermatogenesis

Authors: Qixin Guo, Yong Jiang, Hao Bai, Guohong Chen, Guobin Chang

Journal: Genes (Basel)

PubMed ID: 34828300

Doi: 10.3390/genes12111695

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Bright and stable luminescent probes for target engagement profiling in live cells

Authors: N Connor Payne, Alena S Kalyakina, Kritika Singh, Mark A Tye, Ralph Mazitschek

Journal: Nat Chem Biol

PubMed ID: 34675420

Doi: 10.1038/s41589-021-00877-5

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Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle-Based Small Interfering RNA

Authors: Xin Duan, Lei Cai, Christine T N Pham, Yousef Abu-Amer, Hua Pan, Robert H Brophy, Samuel A Wickline, Muhammad Farooq Rai

Journal: Arthritis Rheumatol

PubMed ID: 33982891

Doi: 10.1002/art.41794

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Biophysical Characterization of Iron-Sulfur Proteins

Authors: Bhanu P Jagilinki, Irina Paluy, Alexei M Tyryshkin, Vikas Nanda, Dror Noy

Journal: Bio Protoc

PubMed ID: 34761074

Doi: 10.21769/BioProtoc.4202

Products & Services: Plasmid DNA Preparation

Serological response to mRNA and inactivated COVID-19 vaccine in healthcare workers in Hong Kong: decline in antibodies 12 weeks after two doses

Authors: J S T Zee, K T W Lai, M K S Ho, A C P Leung, L H Fung, W P Luk, L F Kwok, K M Kee, Q W L Chan, S F Tang, E S K Ma, K H Lee, C C Lau, R W H Yung

Journal: Hong Kong Med J

PubMed ID: 34657837

Doi: 10.12809/hkmj219744

Human Antibody Domains and Fragments Targeting Neutrophil Elastase as Candidate Therapeutics for Cancer and Inflammation-Related Diseases

Authors: Xiaojie Chu, Zehua Sun, Du-San Baek, Wei Li, John W Mellors, Steven D Shapiro, Dimiter S Dimitrov

Journal: Int J Mol Sci

PubMed ID: 34681796

Doi: 10.3390/ijms222011136

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A New Hybrid Protein Is a Novel Regulator for Experimental Colitis in Rats

Authors: Kohki Okada, Masaki Ikemoto

Journal: Inflammation

PubMed ID: 34628574

Doi: 10.1007/s10753-021-01537-5

Products & Services: Proteins, Expression, Isolation and Analysis

Circulating bioactive bacterial DNA is associated with immune activation and complications in common variable immunodeficiency

Authors: Hsi-En Ho, Lin Radigan, Gerold Bongers, Ahmed El-Shamy, Charlotte Cunningham-Rundles

Journal: JCI Insight

PubMed ID: 34622805

Doi: 10.1172/jci.insight.144777

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Self-inhibitory peptides targeting the MtrCDE efflux pump increase antibiotic susceptibility

Authors: Benjamin J Evert, Valentin A Slesarenko, Jilsy M J Punnasseril, Jian Zhan, Yaoqi Zhou, Evgeny A Semchenko, Kate L Seib

Journal: Antimicrob Agents Chemother

PubMed ID: 34633841

Doi: 10.1128/AAC.01542-21

Products & Services: Peptide Synthesis

8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules

Authors: Tamás Pivarcsik, Orsolya Dömötör, János P Mészáros, Nóra V May, Gabriella Spengler, Oszkár Csuvik, István Szatmári, Éva A Enyedy

Journal: Int J Mol Sci

PubMed ID: 34681939

Doi: 10.3390/ijms222011281

Products & Services: Gene Synthesis

High salt diet-induced proximal tubular phenotypic changes and sodium-glucose cotransporter-2 expression are coordinated by cold shock Y-box binding protein-1

Authors: Anja Bernhardt, Saskia Häberer, JingJing Xu, Hannah Damerau, Johannes Steffen, Charlotte Reichardt, Katharina Wolters, Hannes Steffen, Berend Isermann, Katrin Borucki, Nadine Artelt, Nicole Endlich, Renata Kozyraki, Sabine Brandt, Jonathan A Lindquist, Peter R Mertens

Journal: FASEB J

PubMed ID: 34533842

Doi: 10.1096/fj.202100667RR

Products & Services: Proteins, Expression, Isolation and Analysis

Role of African swine fever virus (ASFV) proteins EP153R and EP402R in reducing viral persistence in blood and virulence in pigs infected with BeninΔDP148R

Authors: Vlad Petrovan, Anusyah Rathakrishnan, Muneeb Islam, Lynnette C Goatley, Katy Moffat, Pedro J Sanchez-Cordon, Ana L Reis, Linda K Dixon

Journal: J Virol

PubMed ID: 34643433

Doi: 10.1128/JVI.01340-21

Products & Services: Plasmid DNA Preparation

A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates

Authors: Chang Guo, Yanan Peng, Lin Lin, Xiaoyan Pan, Mengqi Fang, Yun Zhao, Keyan Bao, Runhan Li, Jianbao Han, Jiaorong Chen, Tian-Zhang Song, Xiao-Li Feng, Yahong Zhou, Gan Zhao, Leike Zhang, Yongtang Zheng, Ping Zhu, Haiying Hang, Linqi Zhang, Zhaolin Hua, Hongyu Deng, Baidong Hou

Journal: Cell Rep Med

PubMed ID: 34723223

Doi: 10.1016/j.xcrm.2021.100448

Products & Services: Proteins, Expression, Isolation and Analysis

Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells

Authors: Ying Zhou, Shuhong Zhang, Zhonghan Min, Zhongwei Yu, Huaiwei Zhang, Jiao Jiao

Journal: BMC Cancer

PubMed ID: 34620126

Doi: 10.1186/s12885-021-08779-4

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Characterization of a P-glycoprotein drug transporter from Toxocara canis with a novel pharmacological profile

Authors: Jeba R J Jesudoss Chelladurai, Douglas E Jones, Matthew T Brewer

Journal: Int J Parasitol Drugs Drug Resist

PubMed ID: 34753107

Doi: 10.1016/j.ijpddr.2021.10.002

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Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

Authors: Xia Bu, Vikram R Juneja, Carol G Reynolds, Kathleen M Mahoney, Melissa T Bu, Kathleen A McGuire, Seth Maleri, Ping Hua, Baogong Zhu, Sarah R Klein, Edward A Greenfield, Philippe Armand, Jerome Ritz, Arlene H Sharpe, Gordon J Freeman

Journal: Cancer Immunol Res

PubMed ID: 34635486

Doi: 10.1158/2326-6066.CIR-21-0493

Products & Services: Peptide Synthesis

Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspective

Authors: Jeremy Baldwin, Sakshi Piplani, Isaac G Sakala, Yoshikazu Honda-Okubo, Lei Li, Nikolai Petrovsky

Journal: Bioanalysis

PubMed ID: 34645288

Doi: 10.4155/bio-2021-0096

Products & Services: Recombinant Proteins

Erratum: Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

Authors:

Journal: Front Pharmacol

PubMed ID: 34744755

Doi: 10.3389/fphar.2021.788046

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Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold

Authors: Anjana Kaveri Badekila, Praveen Rai, Sudarshan Kini

Journal: Mol Biol Rep

PubMed ID: 34665400

Doi: 10.1007/s11033-021-06830-y

Products & Services: Molecular Biology Tools

Design of a chitosan-based nano vaccine against epsilon toxin of type D and evaluation of its immunogenicity in BALB/c mice

Authors: Farnaz Poorhassan, Fahimeh Nemati, Parvaneh Saffarian, Seyed Ali Mirhosseini, Mohammad Javad Motamedi

Journal: Res Pharm Sci

PubMed ID: 34760006

Doi: 10.4103/1735-5362.327504

Products & Services: Bacterial Expression

Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro

Authors: Masanori Tsubosaka, Masahiro Maruyama, Elijah Ejun Huang, Ning Zhang, Takeshi Utsunomiya, Qi Gao, Huaishuang Shen, Xueping Li, Junichi Kushioka, Hirohito Hirata, Zhenyu Yao, Yunzhi Peter Yang, Stuart B Goodman

Journal: Bioengineering (Basel)

PubMed ID: 34821731

Doi: 10.3390/bioengineering8110165

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Minimalistic mycoplasmas harbor different functional toxin-antitoxin systems

Authors: Virginia Hill, Hatice Akarsu, Rubén Sánchez Barbarroja, Valentina L Cippà, Peter Kuhnert, Martin Heller, Laurent Falquet, Manfred Heller, Michael H Stoffel, Fabien Labroussaa, Joerg Jores

Journal: PLoS Genet

PubMed ID: 34673769

Doi: 10.1371/journal.pgen.1009365

Products & Services: Catalog Antibody

Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects

Authors: Sabrina Lusvarghi, Wei Wang, Rachel Herrup, Sabari Nath Neerukonda, Russell Vassell, Lisa Bentley, Ann E Eakin, Karl J Erlandson, Carol D Weiss

Journal: J Virol

PubMed ID: 34668774

Doi: 10.1128/JVI.01110-21

Products & Services: Plasmid DNA Preparation

The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains

Authors: Jocelyn D Weissman, Amit K Singh, Ballachanda N Devaiah, Peter Schuck, Ross C LaRue, Dinah S Singer

Journal: J Biol Chem

PubMed ID: 34688663

Doi: 10.1016/j.jbc.2021.101326

Products & Services: Proteins, Expression, Isolation and Analysis

The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization

Authors: Anna Schorcht, Christopher A Cottrell, Pavel Pugach, Rajesh P Ringe, Alvin X Han, Joel D Allen, Tom L G M van den Kerkhof, Gemma E Seabright, Edith E Schermer, Thomas J Ketas, Judith A Burger, Jelle van Schooten, Celia C LaBranche, Gabriel Ozorowski, Natalia de Val, Daniel L V Bader, Hanneke Schuitemaker, Colin A Russell, David C Montefiori, Marit J van Gils, Max Crispin, P J Klasse, Andrew B Ward, John P Moore, Rogier W Sanders

Journal: J Virol

PubMed ID: 34669426

Doi: 10.1128/JVI.01552-21

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Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein

Authors: Chao Wu, Abraham J Qavi, Austin B Moyle, Nicole D Wagner, Asmaa Hachim, Niloufar Kavian, Aidan R Cole, Joyce Sweeney-Gibbons, Henry W Rohrs, J S Malik Peiris, Christopher F Basler, Michael L Gross, Sophie A Valkenburg, Christopher W Farnsworth, Gaya K Amarasinghe, Daisy W Leung

Journal: STAR Protoc

PubMed ID: 34642671

Doi: 10.1016/j.xpro.2021.100906

Products & Services: Gene Synthesis

Protective effect of sargahydroquinoic acid against Aβ-evoked damage via PI3K/Akt mediated Nrf2 antioxidant defense system

Authors: Jeong-Hyun Yoon, Kumju Youn, Mira Jun

Journal: Biomed Pharmacother

PubMed ID: 34619494

Doi: 10.1016/j.biopha.2021.112271

Products & Services: Proteins, Expression, Isolation and Analysis

Systemic autoimmune myopathies: A prospective phase 4 controlled trial of an inactivated virus vaccine against SARS-CoV-2

Authors: Samuel K Shinjo, Fernando H C de Souza, Isabela B P Borges, Alexandre M Dos Santos, Renata Miossi, Rafael G Misse, Ana C Medeiros-Ribeiro, Carla G S Saad, Emily F N Yuki, Sandra G Pasoto, Léonard V K Kupa, Carina Ceneviva, Júlia C Seraphim, Tatiana N Pedrosa, Margarete B G Vendramini, Clóvis A Silva, Nádia E Aikawa, Eloisa Bonfá

Journal: Rheumatology (Oxford)

PubMed ID: 34664616

Doi: 10.1093/rheumatology/keab773

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Biochemical and structural studies of two tetrameric nucleoside 2'-deoxyribosyltransferases from psychrophilic and mesophilic bacteria: Insights into cold-adaptation

Authors: Jesús Fernández-Lucas, Iván Acebrón, Ruiying Y Wu, Yohana Alfaro, Javier Acosta, Pierre A Kaminski, Miguel Arroyo, Andrzej Joachimiak, Boguslaw P Nocek, Isabel De la Mata, José M Mancheño

Journal: Int J Biol Macromol

PubMed ID: 34624379

Doi: 10.1016/j.ijbiomac.2021.09.164

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The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2

Authors: Ria Aryani Hayuningtyas, Myeonggil Han, Seoyeon Choi, Man Sup Kwak, In Ho Park, Ji-Hyun Lee, Ji Eun Choi, Dae Ki Kim, Myoungsun Son, Jeon-Soo Shin

Journal: Mol Med

PubMed ID: 34602056

Doi: 10.1186/s10020-021-00388-y

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The Slower Antibody Response in Myelofibrosis Patients after Two Doses of mRNA SARS-CoV-2 Vaccine Calls for a Third Dose

Authors: Fabio Fiorino, Anna Sicuranza, Annalisa Ciabattini, Adele Santoni, Gabiria Pastore, Martina Simoncelli, Jacopo Polvere, Sara Galimberti, Stefano Auddino, Claudia Baratè, Francesca Montagnani, Vincenzo Sammartano, Monica Bocchia, Donata Medaglini

Journal: Biomedicines

PubMed ID: 34680595

Doi: 10.3390/biomedicines9101480

Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Authors: H R Teni Nurlatifah, Wisnu Barlianto, Wayan Arsana Wiyasa, Chandra Kusuma, Tita Luthfia Sari, Novilia Sjafri Bachtiar

Journal: Med Arch

PubMed ID: 35169353

Doi: 10.5455/medarh.2021.75.335-339

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Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Authors: H R Teni Nurlatifah, Wisnu Barlianto, Wayan Arsana Wiyasa, Chandra Kusuma, Tita Luthfia Sari, Novilia Sjafri Bachtiar

Journal: Med Arch

PubMed ID: 35169353

Doi: 10.5455/medarh.2021.75.335-339

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Anticancer properties of colicin E7 against colon cancer

Authors: Morovat Taherikalani, Sobhan Ghafourian

Journal: Prz Gastroenterol

PubMed ID: 34976246

Doi: 10.5114/pg.2021.109622

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A dedicated flavin-dependent monooxygenase catalyzes the hydroxylation of demethoxyubiquinone into ubiquinone (coenzyme Q) in Arabidopsis

Authors: Scott Latimer, Shea A Keene, Lauren R Stutts, Antoine Berger, Ann C Bernert, Eric Soubeyrand, Janet Wright, Catherine F Clarke, Anna K Block, Thomas A Colquhoun, Christian Elowsky, Alan Christensen, Mark A Wilson, Gilles J Basset

Journal: J Biol Chem

PubMed ID: 34626646

Doi: 10.1016/j.jbc.2021.101283

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Enhanced bone regeneration via spatiotemporal and controlled delivery ofa genetically engineered BMP-2 in a composite Hydrogel

Authors: Xin Chen , Baoyu Tan , Zhiteng Bao , Shang Wang , Rongze Tang , Zhenmin Wang , Gaoyang Chen , Shuai Chen , William W Lu , Dazhi Yang , Songlin Peng

Journal: Biomaterials

PubMed ID: 34517277

Doi: doi.org/10.1016/j.biomaterials.2021.121117

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Mitoxantrone dihydrochloride, an FDA approved drug, binds with SARS-CoV-2 NSP1 C-terminal

Authors: Prateek Kumar, ProfileTaniya Bhardwaj, ProfileRajanish Giri

Journal: biorxiv

Doi: doi.org/10.1101/2021.09.14.460211

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Orthogonal CRISPR-associated transposases for parallel and multiplexed chromosomal integration

Authors: Siqi Yang, Yiwen Zhang, Jiaqi Xu, Jiao Zhang, Jieze Zhang, Junjie Yang, Yu Jiang, Sheng Yang

Journal: Nucleic Acids Res

PubMed ID: 34478496

Doi: 10.1093/nar/gkab752

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Regulation of human mTOR complexes by DEPTOR

Authors: Matthias Wälchli, Karolin Berneiser, Francesca Mangia, Stefan Imseng, Louise-Marie Craigie, Edward Stuttfeld, Michael N Hall, Timm Maier

Journal: Elife

PubMed ID: 34519268

Doi: 10.7554/eLife.70871

Products & Services: Proteins, Expression, Isolation and Analysis

Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians

Authors: Jessica Manning, Irfan Zaidi, Chanthap Lon, Luz Angela Rosas, Jae-Keun Park, Aiyana Ponce, Jennifer Bohl, Sophana Chea, Maria Karkanitsa, Sokunthea Sreng, Huy Rekol, Char Meng Chour, Dominic Esposito, Jeffery K Taubenberger, Matthew J Memoli, Kaitlyn Sadtler, Patrick E Duffy, Fabiano Oliveira

Journal: medrxiv

PubMed ID: 34611671

Doi: 10.1101/2021.09.27.21264000

Products & Services: Proteins, Expression, Isolation and Analysis

Analytical and clinical performance of cPass neutralizing antibodies assay

Authors: Joanna Jung, Deepthi Rajapakshe, Christopher Julien, Sridevi Devaraj

Journal: Clin Biochem

PubMed ID: 34560062

Doi: 10.1016/j.clinbiochem.2021.09.008

Products & Services: Proteins, Expression, Isolation and Analysis

Kinase-Catalyzed Biotinylation to Map Cell Signaling Pathways: Application to Epidermal Growth Factor Signaling

Authors: Vindya Ramanayake-Mudiyanselage, D Maheeka Embogama, Mary Kay H Pflum

Journal: J Proteome Res

PubMed ID: 34491762

Doi: 10.1021/acs.jproteome.1c00562

Products & Services: Proteins, Expression, Isolation and Analysis

A Small Cysteine-Rich Phytotoxic Protein of Functions as Both Plant Defense Elicitor and Virulence Factor

Authors: Zi-Hui Zhang, Jing-Hao Jin, Gui-Lin Sheng, Yu-Ping Xing, Wang Liu, Xue Zhou, Yi-Qing Liu, Xiao-Ren Chen

Journal: Mol Plant Microbe Interact

PubMed ID: 33819070

Doi: 10.1094/MPMI-01-21-0025-R

Products & Services: Proteins, Expression, Isolation and Analysis

A Closer Look into FDA-EUA Approved Diagnostic Techniques of Covid-19

Authors: Hyunju Oh, Hyunjeong Ahn, Anubhav Tripathi

Journal: ACS Infect Dis

PubMed ID: 34569778

Doi: 10.1021/acsinfecdis.1c00268

Products & Services: Proteins, Expression, Isolation and Analysis

Consumption of gossypol increases fatty acid-amino acid conjugates in the cotton pests Helicoverpa armigera and Heliothis virescens

Authors: Corinna Krempl, Nicole Joußen, Michael Reichelt, Marco Kai, Heiko Vogel, David G Heckel

Journal: Arch Insect Biochem Physiol

PubMed ID: 34490676

Doi: 10.1002/arch.21843

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a nanobody-based competitive ELISA for efficiently and specifically detecting antibodies against genotype 2 porcine reproductive and respiratory syndrome viruses

Authors: Hong Duan, Xu Chen, Jiakai Zhao, Jiahong Zhu, Guixi Zhang, Mengnan Fan, Beibei Zhang, Xueting Wang, Yani Sun, Baoyuan Liu, En-Min Zhou, Qin Zhao

Journal: J Clin Microbiol

PubMed ID: 34524888

Doi: 10.1128/JCM.01580-21

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The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs

Authors: Lung-Yu Liang, Michael Roy, Christopher R Horne, Jarrod J Sandow, Minglyanna Surudoi, Laura F Dagley, Samuel N Young, Toby Dite, Jeffrey J Babon, Peter W Janes, Onisha Patel, James M Murphy, Isabelle S Lucet

Journal: Biochem J

PubMed ID: 34431498

Doi: 10.1042/BCJ20210572

Products & Services: DNA Sequencing

Genic male sterility increases rice drought tolerance

Authors: Jianyu Wen, Yafei Zeng, Yunping Chen, Fengfeng Fan, Shaoqing Li

Journal: Plant Sci

PubMed ID: 34620451

Doi: 10.1016/j.plantsci.2021.111057

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