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Identification of a MarR subfamily that regulates arsenic resistance genes

Authors: Yanshuang Yu, Jichen Chen, Yuanping Li, Jinxuan Liang, Zhenchen Xie, Renwei Feng, Hend A Alwathnani, Barry P Rosen, Anne Grove, Jian Chen, Christopher Rensing

Journal: Appl Environ Microbiol

PubMed ID: 34613763

Doi: 10.1128/AEM.01588-21

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Functional Characterization of a New Bifunctional Terpene Synthase LpNES1 from a Medicinal Plant Laggera pter odonta

Authors: Zhan-Ku Shi, Xiao-Wei Gong, Jiang-Yuan Zhao, Ming-Gang Li, Xiu-Lin Han, Meng-Liang Wen

Journal: J Oleo Sci

PubMed ID: 34645748

Doi: 10.5650/jos.ess21172

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NMR study of macro domains (MDs) from betacoronavirus: backbone resonance assignments of SARS-CoV and MERS-CoV MDs in the free and the ADPr-bound state

Authors: Aikaterini C Tsika, Nikolaos K Fourkiotis, Periklis Charalampous, Angelo Gallo, Georgios A Spyroulias

Journal: Biomol NMR Assign

PubMed ID: 34686999

Doi: 10.1007/s12104-021-10052-5

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I-SceI and customized meganucleases-mediated genome editing in tomato and oilseed rape

Authors: Benoit Danilo, Émilie Montes, Héloïse Archambeau, Maryse Lodé, Mathieu Rousseau-Gueutin, Anne-Marie Chèvre, Marianne Mazier

Journal: Transgenic Res

PubMed ID: 34632562

Doi: 10.1007/s11248-021-00287-2

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Identification of novel positive allosteric modulators of GLP1R that stimulate its interaction with ligands and G subunits

Authors: Sumin Kang, Nam Hyuk Kim, Yeon Gyu Yu

Journal: Biochem Biophys Res Commun

PubMed ID: 34739856

Doi: 10.1016/j.bbrc.2021.10.071

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AKIRIN2 controls the nuclear import of proteasomes in vertebrates

Authors: Melanie de Almeida, Matthias Hinterndorfer, Hanna Brunner, Irina Grishkovskaya, Kashish Singh, Alexander Schleiffer, Julian Jude, Sumit Deswal, Robert Kalis, Milica Vunjak, Thomas Lendl, Richard Imre, Elisabeth Roitinger, Tobias Neumann, Susanne Kandolf, Michael Schutzbier, Karl Mechtler, Gijs A Versteeg, David Haselbach, Johannes Zuber

Journal: Nature

PubMed ID: 34711951

Doi: 10.1038/s41586-021-04035-8

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Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice

Authors: Dolors Puigoriol-Illamola, Júlia Companys-Alemany, Kris McGuire, Natalie Z M Homer, Rosana Leiva, Santiago Vázquez, Damian J Mole, Christian Griñán-Ferré, Mercè Pallàs

Journal: Pharmaceuticals (Basel)

PubMed ID: 34681264

Doi: 10.3390/ph14101040

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Intronic variants of MITF (rs7623610) and CREB1 (rs10932201) genes may enhance splicing efficiency in human melanoma cell line

Authors: Juliana Carron, Caroline Torricelli, Janet Keller Silva, Lilian de Oliveira Coser, Carmen Silvia Passos Lima, Gustavo Jacob Lourenço

Journal: Mutat Res

PubMed ID: 34710701

Doi: 10.1016/j.mrfmmm.2021.111763

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A Novel Actinobacterial Cutinase Containing a Non-Catalytic Polymer-Binding Domain

Authors: Kofi Abokitse, Stephan Grosse, Hannes Leisch, Christopher R Corbeil, Florence Perrin-Sarazin, Peter C K Lau

Journal: Appl Environ Microbiol

PubMed ID: 34705546

Doi: 10.1128/AEM.01522-21

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Creation of a synthesis-friendly inflammation-inducible promoter suitable for cell therapy

Authors: Anish Jadav, Kevin Truong

Journal: Integr Biol (Camb)

PubMed ID: 34632498

Doi: 10.1093/intbio/zyab015

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Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase

Authors: Trey A Ronnebaum, Samuel A Eaton, Emily A E Brackhahn, David W Christianson

Journal: Biochemistry

PubMed ID: 34609847

Doi: 10.1021/acs.biochem.1c00600

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The pentatricopeptide repeat protein EMB1270 interacts with CFM2 to splice specific group II introns in Arabidopsis chloroplasts

Authors: Li Zhang, Jingli Chen, Liqun Zhang, Ying Wei, Yajuan Li, Xinyun Xu, Hui Wu, Zhong-Nan Yang, Jirong Huang, Fenhong Hu, Weihua Huang, Yong-Lan Cui

Journal: J Integr Plant Biol

PubMed ID: 34427970

Doi: 10.1111/jipb.13165

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Multiple nanocages of a cyanophage small heat shock protein with icosahedral and octahedral symmetries

Authors: Sreeparna Biswas, Priyanka Garg, Somnath Dutta, Kaza Suguna

Journal: Sci Rep

PubMed ID: 34697325

Doi: 10.1038/s41598-021-00172-2

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An intrinsically disordered nascent protein interacts with specific regions of the ribosomal surface near the exit tunnel

Authors: Valeria Guzman-Luna, Andrew M Fuchs, Anna J Allen, Alexios Staikos, Silvia Cavagnero

Journal: Commun Biol

PubMed ID: 34716402

Doi: 10.1038/s42003-021-02752-4

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N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate

Authors: Leah Gottlieb, Lin Guo, James Shorter, Ronen Marmorstein

Journal: J Biol Chem

PubMed ID: 34732320

Doi: 10.1016/j.jbc.2021.101363

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Development of peptides targeting receptor binding site of the envelope glycoprotein to contain the West Nile virus infection

Authors: Patrícia Mertinková, Evelína Mochnáčová, Katarína Bhide, Amod Kulkarni, Zuzana Tkáčová, Jana Hruškovicová, Mangesh Bhide

Journal: Sci Rep

PubMed ID: 34635758

Doi: 10.1038/s41598-021-99696-w

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Roles of virulence regulator ToxR in viable but non-culturable formation by controlling reactive oxygen species resistance in pathogen Vibrio alginolyticus

Authors: Mengqing Zhou, Yuping Huang, Yuanxing Zhang, Qiyao Wang, Yue Ma, Shuai Shao

Journal: Microbiol Res

PubMed ID: 34700184

Doi: 10.1016/j.micres.2021.126900

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Early IgG / IgA response in hospitalized COVID-19 patients is associated with a less severe disease

Authors: Giorgio Fedele, Gianluca Russo, Ilaria Schiavoni, Pasqualina Leone, Eleonora Olivetta, Valentina Perri, Maria Antonella Zingaropoli, Maria Rosa Ciardi, Patrizia Pasculli, Claudio Maria Mastroianni, Paola Stefanelli

Journal: Diagn Microbiol Infect Dis

PubMed ID: 34742119

Doi: 10.1016/j.diagmicrobio.2021.115586

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and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis

Authors: Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li, Zhan Zhang

Journal: Food Funct

PubMed ID: 34532729

Doi: 10.1039/d1fo02172a

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Interaction of Amyloid-β-(1-42) Peptide and Its Aggregates with Lipid/Water Interfaces Probed by Vibrational Sum-Frequency Generation Spectroscopy

Authors: S Strazdaite, S J Roeters, A Sakalauskas, T Sneideris, J Kirschner, K B Pedersen, B Schiøtt, F Jensen, T Weidner, V Smirnovas, G Niaura

Journal: J Phys Chem B

PubMed ID: 34597059

Doi: 10.1021/acs.jpcb.1c04882

Guillain-Barré syndrome after coronavirus disease 2019 vaccine: A temporal association

Authors: Gustavo Figueiredo da Silva, Caroline Figueiredo da Silva, Raddib Eduardo Noleto da Nobrega Oliveira, Fabiana Romancini, Rafael Marques Mendes, Amanda Locks, Maria Francisca Moro Longo, Carla Heloisa Cabral Moro, Alexandre Luiz Longo, Vera Lucia Braatz

Journal: Clin Exp Neuroimmunol

PubMed ID: 34900000

Doi: 10.1111/cen3.12678

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Characterization of backbone dynamics using solution NMR spectroscopy to discern the functional plasticity of structurally analogous proteins

Authors: Ashish A Kawale, Björn M Burmann

Journal: STAR Protoc

PubMed ID: 34761231

Doi: 10.1016/j.xpro.2021.100919

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The Weak Small RNA-Binding Activity of the 2b Proteins of Subgroup II Cucumber Mosaic Virus Strains Is Insufficient for RNA Silencing Suppression

Authors: Yingying Gao, Jinrui Yang, Xiaobei Zhang, Aizhong Chen, Zhouhang Gu, Zhiyou Du

Journal: Front Microbiol

PubMed ID: 34745069

Doi: 10.3389/fmicb.2021.760937

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A Novel Rice Curl Dwarf-Associated Picornavirus Encodes a 3C Serine Protease Recognizing Uncommon EPT/S Cleavage Sites

Authors: Tianze Zhang, Chenyang Li, Mengji Cao, Dan Wang, Qi Wang, Yi Xie, Shibo Gao, Shuai Fu, Xueping Zhou, Jianxiang Wu

Journal: Front Microbiol

PubMed ID: 34721366

Doi: 10.3389/fmicb.2021.757451

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Mutations Suppressing the Lack of Prepilin Peptidase Provide Insights Into the Maturation of the Major Pilin Protein in Cyanobacteria

Authors: Markéta Linhartová, Petra Skotnicová, Kaisa Hakkila, Martin Tichý, Josef Komenda, Jana Knoppová, Joan F Gilabert, Victor Guallar, Taina Tyystjärvi, Roman Sobotka

Journal: Front Microbiol

PubMed ID: 34712217

Doi: 10.3389/fmicb.2021.756912

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Cationic Channel TRPV2 Overexpression Promotes Resistance to Cisplatin-Induced Apoptosis in Gastric Cancer Cells

Authors: Simona Laurino, Pellegrino Mazzone, Vitalba Ruggieri, Pietro Zoppoli, Giovanni Calice, Antonella Lapenta, Mario Ciuffi, Orazio Ignomirelli, Giulia Vita, Alessandro Sgambato, Sabino Russi, Geppino Falco

Journal: Front Pharmacol

PubMed ID: 34671260

Doi: 10.3389/fphar.2021.746628

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Effectively auto-regulated adsorption and recovery of rare earth elements via an engineered E coli

Authors: Xiaoman Xie, Xirui Tan, Yiyan Yu, Yunchong Li, Pengbo Wang, Yuanhao Liang, Yunjun Yan

Journal: J Hazard Mater

PubMed ID: 34775317

Doi: 10.1016/j.jhazmat.2021.127642

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Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates

Authors: Anahita Nejatfard, Nicholas Wauer, Satarupa Bhaduri, Adam Conn, Saroj Gourkanti, Narinderbir Singh, Tiffany Kuo, Rachel Kandel, Rommie E Amaro, Sonya E Neal

Journal: Cell Rep

PubMed ID: 34686332

Doi: 10.1016/j.celrep.2021.109840

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Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Authors: Ning Tsao, Joshua R Brickner, Rebecca Rodell, Adit Ganguly, Matthew Wood, Clement Oyeniran, Tanveer Ahmad, Hua Sun, Albino Bacolla, Lisheng Zhang, Valentina Lukinović, Jennifer M Soll, Brittany A Townley, Alexandre G Casanova, John A Tainer, Chuan He, Alessandro Vindigni, Nicolas Reynoird, Nima Mosammaparast

Journal: Mol Cell

PubMed ID: 34686315

Doi: 10.1016/j.molcel.2021.09.024

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Nep1‐like Proteins from Valsa mali Differentially Regulate Pathogen Virulence and Response to Abiotic Stresses

Authors: Jianying Liu, Jiajun Nie, Yali Chang, Lili Huang

Journal: Journal of Fungi

Doi: 10.3390/jof7100830

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Porcine TRIM35 positively regulate TRAF3-mediated IFN-β production and inhibit Japanese encephalitis virus replication

Authors: Chenxi Li, Yanyang Zhou, Xuan Chen, Yanbing Zhang, Jingbo Hu, Cicheng Ren, Jingjing Ding, Daoyuan Jiang, Yanhua Li

Journal: Dev Comp Immunol

PubMed ID: 34626690

Doi: 10.1016/j.dci.2021.104290

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USP15 antagonizes CRL4CRBN-mediated ubiquitylation of glutamine synthetase and neosubstrates

Authors: Thang Van Nguyen

Journal: Proc Natl Acad Sci USA

PubMed ID: 34583995

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Roles of Small Subunits of Laccase (ssPOXA3a/b) in Laccase Production by Pleurotus eryngii var. ferulae

Authors: Qi Zhang, Chang Yuan, Feng Wang, Sha Xu, Youran Li, Guiyang Shi, Zhongyang Ding

Journal: J Agric Food Chem.

PubMed ID: 34696587

Doi: doi.org/10.1021/acs.jafc.1c04777

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Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL pro substrate degradome

Authors: Isabel Pablos, Yoan Machado, Hugo C Ramos de Jesus, Yasir Mohamud, Reinhild Kappelhoff, Cecilia Lindskog, Marli Vlok, Peter A Bell, Georgina S Butler, Peter M Grin, Quynh T Cao, Jenny P Nguyen, Nestor Solis, Srinivas Abbina, Wioletta Rut, John C Vederas, Laszlo Szekely, Attila Szakos, Marcin Drag, Jayachandran N Kizhakkedathu, Karen Mossman, Jeremy A Hirota, Eric Jan, Honglin Luo, Arinjay Banerjee, Christopher M Overall

Journal: Cell Rep

PubMed ID: 34672947

Doi: 10.1016/j.celrep.2021.109892

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SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection

Authors: Yan Zhan, Yufang Zhu, Shanshan Wang, Shijun Jia, Yunling Gao, Yingying Lu, Caili Zhou, Ran Liang, Dingwen Sun, Xiaobo Wang, Zhibing Hou, Qiaoqiao Hu, Peng Du, Hao Yu, Chang Liu, Miao Cui, Gangling Tong, Zhihua Zheng, Yunsheng Xu, Linyu Zhu, Jin Cheng, Feng Wu, Yulan Zheng, Peijun Liu, Peng Hong

Journal: Signal Transduct Target Ther

PubMed ID: 34645784

Doi: 10.1038/s41392-021-00777-z

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Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation

Authors: Weixiang Bian, Mengfan Tang, Hua Jiang, Wenyan Xu, Wanyu Hao, Yue Sui, Yingnan Hou, Litong Nie, Huimin Zhang, Chao Wang, Nan Li, Jiadong Wang, Jun Qin, Lianfeng Wu, Xianjue Ma, Junjie Chen, Wenqi Wang , Xu Li

Journal: Dev Cell

PubMed ID: 34626540

Doi: 10.1016/j.devcel.2021.09.015

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CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense

Authors: Xue-Peng Li, Guan-Yu Chen, Qiu Jin, Fang-Rui Lou, Bing-Jian Liu, Jian Zhang, Ji-Xing Feng, Tian-Tian Chen

Journal: Int J Biol Macromol

PubMed ID: 34666131

Doi: 10.1016/j.ijbiomac.2021.10.080

Products & Services: Proteins, Expression, Isolation and Analysis

Enterovirus Infection Restricts Long Interspersed Element 1 Retrotransposition

Authors: Yan Li, Siyu Shen, Haoran Guo, Zhe Zhang, Lili Zhang, Qingran Yang, Yanhang Gao, Junqi Niu, Wei Wei

Journal: Front Microbiol

PubMed ID: 34733242

Doi: 10.3389/fmicb.2021.706241

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Distinct effects on the secretion of MTRAP and AMA1 in Plasmodium yoelii following deletion of acylated pleckstrin homology domain-containing protein

Authors: Nattawat Chaiyawong, Takahiro Ishizaki, Hassan Hakimi, Masahito Asada, Kazuhide Yahata, Osamu Kaneko

Journal: Parasitol Int

PubMed ID: 34628068

Doi: 10.1016/j.parint.2021.102479

Products & Services: Proteins, Expression, Isolation and Analysis

The Long-Term Effect of a Nine Amino-Acid Antimicrobial Peptide AS-hepc3 Against With No Detectable Resistance

Authors: Depeng Zhu, Fangyi Chen, Yan-Chao Chen, Hui Peng, Ke-Jian Wang

Journal: Front Cell Infect Microbiol

PubMed ID: 34676176

Doi: 10.3389/fcimb.2021.752637

Products & Services: Proteins, Expression, Isolation and Analysis

Ethylene-induced NbMYB4L is involved in resistance against tobacco mosaic virus in Nicotiana benthamiana

Authors: Tong Zhu, Xue Zhou, Jian-Long Zhang, Wei-Hao Zhang, Li-Pei Zhang, Chun-Xiang You, Paula E Jameson, Peng-Tao Ma, Shan-Li Guo

Journal: Mol Plant Pathol

PubMed ID: 34633738

Doi: 10.1111/mpp.13139

Products & Services: Proteins, Expression, Isolation and Analysis

NORHA, a novel follicular atresia-related lncRNA, promotes porcine granulosa cell apoptosis via the miR-183-96-182 cluster and FoxO1 axis

Authors: Wang Yao, Zengxiang Pan, Xing Du, Jinbi Zhang, Honglin Liu, Qifa Li

Journal: J Anim Sci Biotechnol

PubMed ID: 34615552

Doi: 10.1186/s40104-021-00626-7

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Lateral flow assays (LFA) as an alternative medical diagnosis method for detection of virus species: The intertwine of nanotechnology with sensing strategies

Authors: Poorya Sadeghi, Hessamaddin Sohrabi, Maryam Hejazi, Ali Jahanban-Esfahlan, Behzad Baradaran, Maryam Tohidast, Mir Reza Majidi, Ahad Mokhtarzadeh, Seyed Mohammad Tavangar, Miguel de la Guardia

Journal: Trends Analyt Chem

PubMed ID: 34697511

Doi: 10.1016/j.trac.2021.116460

Products & Services: Proteins, Expression, Isolation and Analysis

Novel HLA-B7-restricted human metapneumovirus epitopes enhance viral clearance in mice and are recognized by human CD8 T cells

Authors: Margot Miranda-Katz, John J Erickson, Jie Lan, Alwyn Ecker, Yu Zhang, Sebastian Joyce, John V Williams

Journal: Sci Rep

PubMed ID: 34675220

Doi: 10.1038/s41598-021-00023-0

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Arabidopsis fibrillin 1-2 subfamily exerts their functions via specific protein-protein interactions

Authors: Diego Torres-Romero, Ángeles Gómez-Zambrano, Antonio Jesús Serrato, Mariam Sahrawy, Ángel Mérida

Journal: J Exp Bot

PubMed ID: 34651644

Doi: 10.1093/jxb/erab452

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A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge

Authors: Kathryn McGuckin Wuertz, Erica K Barkei, Wei-Hung Chen, Elizabeth J Martinez, Ines Lakhal-Naouar, Linda L Jagodzinski, Dominic Paquin-Proulx, Gregory D Gromowski, Isabella Swafford, Akshaya Ganesh, Ming Dong, Xiankun Zeng, Paul V Thomas, Rajeshwer S Sankhala, Agnes Hajduczki, Caroline E Peterson, Caitlin Kuklis, Sandrine Soman, Lindsay Wieczorek, Michelle Zemil, Alexander Anderson, Janice Darden, Heather Hernandez, Hannah Grove, Vincent Dussupt, Holly Hack, Rafael de la Barrera, Stasya Zarling, James F Wood, Jeffrey W Froude, Matthew Gagne, Amy R Henry, Elham Bayat Mokhtari, Prakriti Mudvari, Shelly J Krebs, Andrew S Pekosz, Jeffrey R Currier, Swagata Kar, Maciel Porto, Adrienne Winn, Kamil Radzyminski, Mark G Lewis, Sandhya Vasan, Mehul Suthar, Victoria R Polonis, Gary R Matyas, Eli A Boritz, Daniel C Douek, Robert A Seder, Sharon P Daye, Mangala Rao, Sheila A Peel, M Gordon Joyce, Diane L Bolton, Nelson L Michael, Kayvon Modjarrad

Journal: npj Vaccines

PubMed ID: 34711815

Doi: 10.1038/s41541-021-00392-7

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Cyclic CMP and cyclic UMP mediate bacterial immunity against phages

Authors: Nitzan Tal, Benjamin R Morehouse, Adi Millman, Avigail Stokar-Avihail, Carmel Avraham, Taya Fedorenko, Erez Yirmiya, Ehud Herbst, Alexander Brandis, Tevie Mehlman, Yaara Oppenheimer-Shaanan, Alexander F A Keszei, Sichen Shao, Gil Amitai, Philip J Kranzusch, Rotem Sorek

Journal: Cell

PubMed ID: 34644530

Doi: 10.1016/j.cell.2021.09.031

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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Authors: Britton Boras, Rhys M Jones, Brandon J Anson, Dan Arenson, Lisa Aschenbrenner, Malina A Bakowski, Nathan Beutler, Joseph Binder, Emily Chen, Heather Eng, Holly Hammond, Jennifer Hammond, Robert E Haupt, Robert Hoffman, Eugene P Kadar, Rob Kania, Emi Kimoto, Melanie G Kirkpatrick, Lorraine Lanyon, Emma K Lendy, Jonathan R Lillis, James Logue, Suman A Luthra, Chunlong Ma, Stephen W Mason, Marisa E McGrath, Stephen Noell, R Scott Obach, Matthew N O' Brien, Rebecca O'Connor, Kevin Ogilvie, Dafydd Owen, Martin Pettersson, Matthew R Reese, Thomas F Rogers, Romel Rosales, Michelle I Rossulek, Jean G Sathish, Norimitsu Shirai, Claire Steppan, Martyn Ticehurst, Lawrence W Updyke, Stuart Weston, Yuao Zhu, Kris M White, Adolfo García-Sastre, Jun Wang, Arnab K Chatterjee, Andrew D Mesecar, Matthew B Frieman, Annaliesa S Anderson, Charlotte Allerton

Journal: Nat Commun

PubMed ID: 34663813

Doi: 10.1038/s41467-021-26239-2

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Development of a therapeutic vaccine targeting Merkel cell polyomavirus capsid protein VP1 against Merkel cell carcinoma

Authors: Dan Xu, Sheng Jiang, Yue He, Xiang Jin, Gan Zhao, Bin Wang

Journal: npj Vaccines

PubMed ID: 34611173

Doi: 10.1038/s41541-021-00382-9

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Primary Infection May Be an Underlying Factor Contributing to Lethal Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesvirus 3 in African Elephants ()

Authors: Taylor Pursell, Jennifer L Spencer Clinton, Jie Tan, Rongsheng Peng, Xiang Qin, Harshavardhan Doddapaneni, Vipin Menon, Zeineen Momin, Kavya Kottapalli, Lauren Howard, Erin Latimer, Sarah Heaggans, Gary S Hayward, Paul D Ling

Journal: Microbiol Spectr

PubMed ID: 34668724

Doi: 10.1128/Spectrum.00983-21

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