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CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8

Authors: Marina Serna, Ana González-Corpas, Sofía Cabezudo, Andrés López-Perrote, Gianluca Degliesposti, Eduardo Zarzuela, J Mark Skehel, Javier Muñoz, Oscar Llorca

Journal: Nucleic Acids Res

PubMed ID: 34951455

Doi: 10.1093/nar/gkab1267

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Blood virosphere in febrile Tanzanian children

Authors: Samuel Cordey, Florian Laubscher, Mary-Anne Hartley, Thomas Junier, Kristina Keitel, Mylène Docquier, Nicolas Guex, Christian Iseli, Gael Vieille, Philippe Le Mercier, Anne Gleizes, Josephine Samaka, Tarsis Mlaganile, Frank Kagoro, John Masimba, Zamzam Said, Hosiana Temba, Gasser H Elbanna, Caroline Tapparel, Marie-Celine Zanella, Ioannis Xenarios, Jacques Fellay, Valérie D'Acremont, Laurent Kaiser

Journal: Emerg Microbes Infect

PubMed ID: 33929935

Doi: 10.1080/22221751.2021.1925161

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Long-term trajectories of SARS-CoV-2 neutralizing antibodies and predictive value of first dose vaccination-induced IgG-antibodies in hemodialysis patients

Authors: F P Tillmann, H Still, Philipp von Landenberg

Journal: Int Urol Nephrol

PubMed ID: 34860338

Doi: 10.1007/s11255-021-03076-2

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Impaired Immune Response to COVID-19 Vaccination in Patients with B-Cell Malignancies after CD19 CART Cell Therapy

Authors: Saurabh Dahiya, Tim Luetkens, Forat Lutfi, Stephanie V Avila, Thierry Iraguha, Philip J Margiotta, Kim G Hankey, Patricia Lesho, Jennie Y Law, Seung Tae Lee, John W Baddley, Mehmet Hakan Kocoglu, Jean Yared, Nancy M Hardy, Aaron P Rapoport, Djordje Atanackovic

Journal: Blood Adv

PubMed ID: 34941995

Doi: 10.1182/bloodadvances.2021006112

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Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA

Authors: Kun Huang, Xiao-Xian Wu, Cheng-Li Fang, Zhou-Geng Xu, Hong-Wei Zhang, Jian Gao, Chuan-Miao Zhou, Lin-Lin You, Zhan-Xi Gu, Wen-Hui Mu, Yu Feng, Jia-Wei Wang, Yu Zhang

Journal: Science

PubMed ID: 34941388

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Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Authors: Edmond M Linossi , Kunlun Li , Gianluca Veggiani , Cyrus Tan , Farhad Dehkhoda , Colin Hockings , Dale J Calleja , Narelle Keating , Rebecca Feltham , Andrew J Brooks , Shawn S Li , Sachdev S Sidhu , Jeffrey J Babon , Nadia J Kershaw , Sandra E Nicholson

Journal: Nat Commun

PubMed ID: 34857742

Doi: s41467-021-26983-5

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Metabolic engineering of Bacillus subtilis with an endopolygalacturonase gene isolated from Pectobacterium carotovorum; a plant pathogenic bacterial strain

Authors: Nagina Rafique, Saiqa Bashir, Muhammad Zubair Khan, Imran Hayat, Willium Orts, Dominic W S Wong

Journal: PLoS ONE

PubMed ID: 34936645

Doi: 10.1371/journal.pone.0256562

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High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster

Authors: Julia R Port, Danielle R Adney, Benjamin Schwarz, Jonathan E Schulz, Daniel E Sturdevant, Brian J Smith, Victoria A Avanzato, Myndi G Holbrook, Jyothi N Purushotham, Kaitlin A Stromberg, Ian Leighton, Catharine M Bosio, Carl Shaia, Vincent J Munster

Journal: Viruses

PubMed ID: 34960775

Doi: 10.3390/v13122506

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Djulis Hull Improves Insulin Resistance and Modulates the Gut Microbiota in High-Fat Diet (HFD)-Induced Hyperglycaemia

Authors: Yu-Tang Tung, Jun-Lan Zeng, Shang-Tse Ho, Jin-Wei Xu, I-Hsuan Lin, Jyh-Horng Wu

Journal: Antioxidants (Basel)

PubMed ID: 35052549

Doi: 10.3390/antiox11010045

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Constructing DNA logic circuits based on the toehold preemption mechanism

Authors: Cuicui Xing, Xuedong Zheng, Qiang Zhang

Journal: RSC Adv

PubMed ID: 35424506

Doi: 10.1039/d1ra08687a

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Novel Tyrosine Kinase-Mediated Phosphorylation With Dual Specificity Plays a Key Role in the Modulation of Physiology and Virulence

Authors: Sashi Kant, Vijay Pancholi

Journal: Front Microbiol

PubMed ID: 34950110

Doi: 10.3389/fmicb.2021.689246

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Modulation of anti-angiogenic activity using ultrasound-activated nutlin-loaded piezoelectric nanovectors

Authors: Özlem Şen, Attilio Marino, Carlotta Pucci, Gianni Ciofani

Journal: Mater Today Bio

PubMed ID: 35005600

Doi: 10.1016/j.mtbio.2021.100196

Products & Services: Gene Fragments

Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Authors: Martin Marek, Elizabeth Ramos-Morales, Gisele F A Picchi-Constante, Theresa Bayer, Carina Norström, Daniel Herp, Policarpo A Sales-Junior, Eloise P Guerra-Slompo, Kristin Hausmann, Alokta Chakrabarti, Tajith B Shaik, Annika Merz, Edouard Troesch, Karin Schmidtkunz, Samuel Goldenberg, Raymond J Pierce, Marina M Mourão, Manfred Jung, Johan Schultz, Wolfgang Sippl, Nilson I T Zanchin, Christophe Romier

Journal: Cell Rep

PubMed ID: 34936867

Doi: 10.1016/j.celrep.2021.110129

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Multiple RNA virus matrix proteins interact with SLD5 to manipulate host cell cycle

Authors: Li Zhu, Xinyu Li, Henan Xu, Lifeng Fu, George Fu Gao, Wenjun Liu, Linqing Zhao, Xiaojun Wang, Wei Jiang, Min Fang

Journal: J Gen Virol

PubMed ID: 34882534

Doi: 10.1099/jgv.0.001697

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In vivo architecture of the telomerase RNA catalytic core in Trypanosoma brucei

Authors: Abhishek Dey, Anais Monroy-Eklund, Kaitlin Klotz, Arpita Saha, Justin Davis, Bibo Li, Alain Laederach, Kausik Chakrabarti

Journal: Nucleic Acids Res

PubMed ID: 34850114

Doi: 10.1093/nar/gkab1042

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β-galactosidase GALA from with high transgalactosylation activity

Authors: Yaru Yan, Weishi Guan, Xiaoyi Li, Kaier Gao, Xinxin Xu, Bo Liu, Wei Zhang, Yuhong Zhang

Journal: Bioengineered

PubMed ID: 34606421

Doi: 10.1080/21655979.2021.1988370

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A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

Authors: Xiangchuan He, Longfei Ding, Kangli Cao, Haoran Peng, Chenjian Gu, Yutang Li, Duoduo Li, Lanlan Dong, Xiujing Hong, Xiangwei Wang, Meilan Fu, Chenli Qiu, Cuisong Zhu, Ziling Zhang, Shu Song, Chenguang Wang, Zhengfan Jiang, Youhua Xie, Zhongtian Qi, Chen Zhao, Ping Zhao, Xiaoyan Zhang, Jianqing Xu

Journal: Emerg Microbes Infect

PubMed ID: 34304724

Doi: 10.1080/22221751.2021.1957400

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Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection

Authors: Jiaojiao Liu, Kun Xu, Man Xing, Yue Zhuo, Jingao Guo, Meng Du, Qi Wang, Yaling An, Jinhe Li, Ping Gao, Yihan Wang, Furong He, Yingying Guo, Mingxi Li, Yuchao Zhang, Linqi Zhang, George F Gao, Lianpan Dai, Dongming Zhou

Journal: Cell Discov

PubMed ID: 34923570

Doi: 10.1038/s41421-021-00360-4

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Platelet Endothelial Cell Adhesion Molecule 1 (CD31) Is Essential for Beta-Toxin Mediated Cytotoxicity in Human Endothelial and Monocytic Cells

Authors: Basma Tarek, Julia Bruggisser, Filippo Cattalani, Horst Posthaus

Journal: Toxins (Basel)

PubMed ID: 34941730

Doi: 10.3390/toxins13120893

Products & Services: Recombinant Antibody Expression

Small molecule splicing modifiers with systemic HTT-lowering activity

Authors: Anuradha Bhattacharyya, Christopher R Trotta, Jana Narasimhan, Kari J Wiedinger, Wencheng Li, Kerstin A Effenberger, Matthew G Woll, Minakshi B Jani, Nicole Risher, Shirley Yeh, Yaofeng Cheng, Nadiya Sydorenko, Young-Choon Moon, Gary M Karp, Marla Weetall, Amal Dakka, Vijayalakshmi Gabbeta, Nikolai A Naryshkin, Jason D Graci, Thomas Tripodi, Amber Southwell, Michael Hayden, Joseph M Colacino, Stuart W Peltz

Journal: Nat Commun

PubMed ID: 34911927

Doi: 10.1038/s41467-021-27157-z

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Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2

Authors: Kristen A Rodrigues, Sergio A Rodriguez-Aponte, Neil C Dalvie, Jeong Hyun Lee, Wuhbet Abraham, Diane G Carnathan, Luis E Jimenez, Julia T Ngo, Jason Y H Chang, Zeli Zhang, Jingyou Yu, Aiquan Chang, Catherine Nakao, Benjamin Goodwin, Christopher A Naranjo, Libin Zhang, Murillo Silva, Dan H Barouch, Guido Silvestri, Shane Crotty, J Christopher Love, Darrell J Irvine

Journal: Sci Adv

PubMed ID: 34878851

Doi: 10.1126/sciadv.abj6538

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Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance

Authors: Yalan Deng, Xianghou Xia, Yang Zhao, Zilong Zhao, Consuelo Martinez, Wenjuan Yin, Jun Yao, Qinglei Hang, Weiche Wu, Jie Zhang, Yang Yu, Weiya Xia, Fan Yao, Di Zhao, Yutong Sun, Haoqiang Ying, Mien-Chie Hung, Li Ma

Journal: Nat Commun

PubMed ID: 34873175

Doi: 10.1038/s41467-021-27349-7

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Characterization of recombinant β subunit of human MUC4 mucin (rMUC4β)

Authors: Prakash G Kshirsagar, Mansi Gulati, Wade M Junker, Abhijit Aithal, Gaelle Spagnol, Srustidhar Das, Kavita Mallya, Shailendra K Gautam, Sushil Kumar, Paul Sorgen, Krishan K Pandey, Surinder K Batra, Maneesh Jain

Journal: Sci Rep

PubMed ID: 34887447

Doi: 10.1038/s41598-021-02860-5

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Biosynthesis of the redox cofactor mycofactocin is controlled by the transcriptional regulator MftR and induced by long chain acyl-CoA species

Authors: Aigera Mendauletova, John A Latham

Journal: J Biol Chem

PubMed ID: 34896395

Doi: 10.1016/j.jbc.2021.101474

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Ultrasound triggered topical delivery of Bmp7 mRNA for white fat browning induction via engineered smart exosomes

Authors: Yitong Guo, Zhuo Wan, Ping Zhao, Mengying Wei, Yunnan Liu, Te Bu, Wenqi Sun, Zhelong Li, Lijun Yuan

Journal: J Nanobiotechnology

PubMed ID: 34863187

Doi: 10.1186/s12951-021-01145-3

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Transmembrane topology and oligomeric nature of an astrocytic membrane protein, MLC1

Authors: Junmo Hwang, Kunwoong Park, Ga-Young Lee, Bo Young Yoon, Hyunmin Kim, Sung Hoon Roh, Byoung-Cheol Lee, Kipom Kim, Hyun-Ho Lim

Journal: Open Biol

PubMed ID: 34847774

Doi: 10.1098/rsob.210103

Products & Services: Mammalian Expression

PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc

Authors: Dalila Boi, Fani Souvalidou, Davide Capelli, Federica Polverino, Grazia Marini, Roberta Montanari, Giorgio Pochetti, Angela Tramonti, Roberto Contestabile, Daniela Trisciuoglio, Patrizia Carpinelli, Camilla Ascanelli, Catherine Lindon, Alessandro De Leo, Michele Saviano, Roberto Di Santo, Roberta Costi, Giulia Guarguaglini, Alessandro Paiardini

Journal: Int J Mol Sci

PubMed ID: 34884931

Doi: 10.3390/ijms222313122

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Antiviral RNA interference in disease vector (Asian longhorned) ticks

Authors: Yan Xu, Zhengwei Zhong, Yanxin Ren, Liting Ma, Zhi Ye, Chuang Gao, Jingwen Wang, Yang Li

Journal: PLoS Pathog

PubMed ID: 34860862

Doi: 10.1371/journal.ppat.1010119

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Cockayne Syndrome B Protein Selectively Resolves and Interact with Intermolecular DNA G-Quadruplex Structures

Authors: Denise Liano, Souroprobho Chowdhury, Marco Di Antonio

Journal: J Am Chem Soc

PubMed ID: 34855372

Doi: 10.1021/jacs.1c10745

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SAF-A mutants disrupt chromatin structure through dominant negative effects on RNAs associated with chromatin

Authors: Heather J Kolpa, Kevin M Creamer, Lisa L Hall, Jeanne B Lawrence

Journal: Mamm Genome

PubMed ID: 34859278

Doi: 10.1007/s00335-021-09935-8

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Angiopoietin-2 silence alleviates lipopolysaccharide-induced inflammation, barrier dysfunction and endoplasmic reticulum stress of intestinal epithelial cells by blocking Notch signaling pathway

Authors: Liying Dai, Shuangshuang Jie, Shaohua Bi, Qing Qing, Jun Chen

Journal: Bioengineered

PubMed ID: 34565297

Doi: 10.1080/21655979.2021.1985341

Products & Services: Protein and Antibody Isolation

A clubroot pathogen effector targets cruciferous cysteine proteases to suppress plant immunity

Authors: Edel Pérez-López, Md Musharaf Hossain, Yangdou Wei, Christopher D Todd, Peta C Bonham-Smith

Journal: Virulence

PubMed ID: 34515618

Doi: 10.1080/21505594.2021.1968684

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Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity

Authors: Tamara Ratovitski, Mali Jiang, Robert N O'Meally, Priyanka Rauniyar, Ekaterine Chighladze, Anikó Faragó, Siddhi V Kamath, Jing Jin, Alexey V Shevelkin, Robert N Cole, Christopher A Ross

Journal: Hum Mol Genet

PubMed ID: 34888656

Doi: 10.1093/hmg/ddab351

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TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA

Authors: Parminder Kaur, Ryan Barnes, Hai Pan, Ariana C Detwiler, Ming Liu, Chelsea Mahn, Jonathan Hall, Zach Messenger, Changjiang You, Jacob Piehler, Robert C Smart, Robert Riehn, Patricia L Opresko, Hong Wang

Journal: Nucleic Acids Res

PubMed ID: 34883513

Doi: 10.1093/nar/gkab1142

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Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Authors: Sandile Cele, Laurelle Jackson, David S Khoury, Khadija Khan, Thandeka Moyo-Gwete, Houriiyah Tegally, James Emmanuel San, Deborah Cromer, Cathrine Scheepers, Daniel G Amoako, Farina Karim, Mallory Bernstein, Gila Lustig, Derseree Archary, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Shi-Hsia Hwa, Jennifer Giandhari, Jonathan M Blackburn, Bernadett I Gosnell, Salim S Abdool Karim, Willem Hanekom, Anne von Gottberg, Jinal N Bhiman, Richard J Lessells, Mahomed-Yunus S Moosa, Miles P Davenport, Tulio de Oliveira, Penny L Moore, Alex Sigal

Journal: Nature

PubMed ID: 35016196

Doi: 10.1038/s41586-021-04387-1

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Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model

Authors: Cheuk Wun Li, Roman Osman, Francesca Menconi, Larissa C Faustino, Kookjoo Kim, Oliver B Clarke, Hanxi Hou, Yaron Tomer

Journal: Front Immunol

PubMed ID: 34987519

Doi: 10.3389/fimmu.2021.796552

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Characterization and expression analysis of the SPL gene family during floral development and abiotic stress in pecan ()

Authors: Min Wang, Zhenghai Mo, Ruozhu Lin, Cancan Zhu

Journal: PeerJ

PubMed ID: 34966577

Doi: 10.7717/peerj.12490

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Simultaneous binding of the N- and C-terminal cytoplasmic domains of aquaporin 4 to calmodulin

Authors: Hiroaki Ishida, Hans J Vogel, Alex C Conner, Philip Kitchen, Roslyn M Bill, Justin A MacDonald

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34890582

Doi: 10.1016/j.bbamem.2021.183837

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Fine-tuning of pathogenesis-related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight

Authors: Jingru Guo, Yujing Bai, Yunxie Wei, Yabin Dong, Hongqiu Zeng, Russel J Reiter, Haitao Shi

Journal: J Pineal Res

PubMed ID: 34936113

Doi: 10.1111/jpi.12784

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An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade

Authors: Shuguang Zuo, Min Wei, Tiancheng Xu, Lingkai Kong, Bohao He, Shiqun Wang, Shibing Wang, Junhua Wu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 34949694

Doi: 10.1136/jitc-2021-002843

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Development of a high-throughput RT-PCR based viral infectivity assay for monitoring the stability of a replicating recombinant Lymphocytic Choriomeningitis viral vector

Authors: Vineet Gupta, Lorena R Antunez, Soraia Saleh-Birdjandi, Ozan S Kumru, Richard Pospisil, Anders Lilja, Gerhard Fuhrmann, Lee Smith, David B Volkin, Sangeeta B Joshi

Journal: J Virol Methods

PubMed ID: 34954306

Doi: 10.1016/j.jviromet.2021.114440

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Comparative analysis of mussel foot protein 3B co-expressed with tyrosinases provides a potential adhesive biomaterial

Authors: Lin Yao, Xinyi Wang, Rui Xue, Hong Xu, Rui Wang, Lujia Zhang, Sha Li

Journal: Int J Biol Macromol

PubMed ID: 34896153

Doi: 10.1016/j.ijbiomac.2021.11.208

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MiR-31 targets HSD17B14 and FSHR, and miR-20b targets HSD17B14 to affect apoptosis and steroid hormone metabolism of porcine ovarian granulosa cells

Authors: Siyuan Gao, Jing Zhao, Qinglei Xu, Yanli Guo, Mingzheng Liu, Chunlei Zhang, Allan P Schinckel, Bo Zhou

Journal: Theriogenology

PubMed ID: 34959084

Doi: 10.1016/j.theriogenology.2021.12.014

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Reversible myocardial injury aggravated by complex arrhythmias in three Toxoplasma gondii-positive dogs

Authors: Giovanni Romito, Elena Venturelli, Vanna Tintorri, Mario Cipone

Journal: J Vet Med Sci

PubMed ID: 34955461

Doi: 10.1292/jvms.21-0571

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A metabolic labeling protocol to enrich myristoylated proteins from

Authors: Xin Gong, Yanwen Feng, Hongyun Tang

Journal: STAR Protoc

PubMed ID: 34917984

Doi: 10.1016/j.xpro.2021.101013

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Key factors determining competitions between double-stranded RNAs in Tribolium castaneum

Authors: Xu Shen, Yingchuan Peng, Huifang Song, Jinda Wang, Jun Zhao, Peian Tang, Zhaojun Han, Kangxu Wang

Journal: Pestic Biochem Physiol

PubMed ID: 35082032

Doi: 10.1016/j.pestbp.2021.105009

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GST-Perfringolysin O production for the localization and quantification of membrane cholesterol in human and mouse brain and liver

Authors: Leire Goicoechea, Fabian Arenas, Fernanda Castro, Susana Nuñez, Sandra Torres, Carmen Garcia-Ruiz, José C Fernandez-Checa

Journal: STAR Protoc

PubMed ID: 35024626

Doi: 10.1016/j.xpro.2021.101068

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Protein S-Nitrosylation Regulates Postmortem Beef Apoptosis through the Intrinsic Mitochondrial Pathway

Authors: Qin Hou, Qiongniu Zhu, Wenwei Lu, Wangang Zhang

Journal: J Agric Food Chem

PubMed ID: 34968404

Doi: 10.1021/acs.jafc.1c06516

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Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis

Authors: Yi-Ping Liu, Zhong-Zhi Qiu, Xu-Hui Li, En-You Li

Journal: World J Gastrointest Oncol

PubMed ID: 35070046

Doi: 10.4251/wjgo.v13.i12.2114

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CTLA4-Ig treatment induces M1-M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients

Authors: Maurizio Cutolo, Stefano Soldano, Emanuele Gotelli, Paola Montagna, Rosanna Campitiello, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Samuele Tardito

Journal: Arthritis Res Ther

PubMed ID: 34952630

Doi: 10.1186/s13075-021-02691-9

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