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页码: 168/1027 每页显示数量

The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency: a case series

Authors: Min Sun, Jonathan W Mueller, Lorna C Gilligan, Angela E Taylor, Fozia Shaheen, Anna Noczyńska, Guy T'Sjoen, Louise Denvir, Savitha Shenoy, Piers Fulton, Timothy D Cheetham, Helena Gleeson, Mushtaqur Rahman, Nils P Krone, Norman F Taylor, Cedric H L Shackleton, Wiebke Arlt, Jan Idkowiak

Journal: Eur J Endocrinol

PubMed ID: 34524979

Doi: 10.1530/EJE-21-0152

Products & Services: Mutant Libraries

Structural evidence for visual arrestin priming via complexation of phosphoinositols

Authors: Christopher L Sander, Jennings Luu, Kyumhyuk Kim, David Furkert, Kiyoung Jang, Joerg Reichenwallner, MinSoung Kang, Ho-Jun Lee, Bryan T Eger, Hui-Woog Choe, Dorothea Fiedler, Oliver P Ernst, Yong Ju Kim, Krzysztof Palczewski, Philip D Kiser

Journal: Structure

PubMed ID: 34678158

Doi: 10.1016/j.str.2021.10.002

Products & Services: Mutant Libraries

SARS-CoV-2 Neutralizing Antibody Levels Post COVID-19 Vaccination Based on ELISA Method-A Small Real-World Sample Exploration

Authors: Xiaoguang Li, Chao Liang, Xiumei Xiao

Journal: Vaccines (Basel)

PubMed ID: 34696247

Doi: 10.3390/vaccines9101139

Products & Services: Molecular Biology Reagents

Dexmedetomidine alleviates hepatic ischaemia-reperfusion injury via the PI3K/AKT/Nrf2-NLRP3 pathway

Authors: Yan Wu, Gaolin Qiu, Hainie Zhang, Leilei Zhu, Gao Cheng, Yiqiao Wang, Yuanhai Li, Weiwei Wu

Journal: J Cell Mol Med

PubMed ID: 34664412

Doi: 10.1111/jcmm.16871

Products & Services: Mammalian Expression

Pro-inflammatory polarization primes Macrophages to transition into a distinct M2-like phenotype in response to IL-4

Authors: Erin M O'Brien, Kara L Spiller

Journal: J Leukoc Biol

PubMed ID: 34643290

Doi: 10.1002/JLB.3A0520-338R

Products & Services: Mammalian Expression

SARS-CoV-2 Delta variant infects ACE2 primary human bronchial epithelial cells more efficiently than other variants

Authors: Hongmei Li, Ting Liu, Liping Wang, Minghui Wang, Shaoqing Wang

Journal: J Med Virol

PubMed ID: 34596249

Doi: 10.1002/jmv.27372

Products & Services: Mammalian Expression

Assessment of Anti-SARS-CoV-2 Antibodies Post-Coronavac Vaccination in the Amazon Region of Brazil

Authors: Carlos David Araújo Bichara, Maria Alice Freitas Queiroz, Ednelza da Silva Graça Amoras, Gergiane Lopes Vaz, Izaura Maria Vieira Cayres Vallinoto, Cléa Nazaré Carneiro Bichara, Isabella Pinheiro Costa do Amaral, Ricardo Ishak, Antonio Carlos Rosário Vallinoto

Journal: Vaccines (Basel)

PubMed ID: 34696277

Doi: 10.3390/vaccines9101169

Products & Services: Immunoassay Development Services

Surface-Tethered Planar Membranes Containing the β-Barrel Assembly Machinery: a platform for Investigating Bacterial Outer Membrane Protein Folding

Authors: Stephen C L Hall, Luke A Clifton, Pooja Sridhar, David J Hardy, Peter Wotherspoon, Jack Wright, James Whitehouse, Nadisha Gamage, Claire S Laxton, Caitlin Hatton, Gareth W Hughes, Mark Jeeves, Timothy J Knowles

Journal: Biophys J

PubMed ID: 34757080

Doi: 10.1016/j.bpj.2021.10.033

Products & Services: GenParts™ DNA Fragments

Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro

Authors: Nicole Farfán, Nicole Sanhueza, Macarena Briones, Luis O Burzio, Verónica A Burzio

Journal: Biol Res

PubMed ID: 34666824

Doi: 10.1186/s40659-021-00356-0

Products & Services: GenParts™ DNA Fragments

Author Correction: Broadly cross-reactive human antibodies that inhibit genogroup I and II noroviruses

Authors: Gabriela Alvarado, Wilhelm Salmen, Khalil Ettayebi, Liya Hu, Banumathi Sankaran, Mary K Estes, B V Venkataram Prasad, James E Crowe

Journal: Nat Commun

PubMed ID: 34650069

Doi: 10.1038/s41467-021-26418-1

Products & Services: GenParts™ DNA Fragments

Biodegradation of 4-hydroxybenzoic acid by Acinetobacter johnsonii FZ-5 and Klebsiella oxytoca FZ-8 under anaerobic conditions

Authors: Peng Lu, Huiying Huang, Yixiao Sun, Mengyao Qiang, Yan Zhu, Mengjiao Cao, Xue Peng, Bo Yuan, Zhaozhong Feng

Journal: Biodegradation

PubMed ID: 34609628

Doi: 10.1007/s10532-021-09963-w

Products & Services: DNA Sequencing

Corrigendum: Upregulated LINC01667 Expression Is Correlated With Poor Prognosis in Hepatocellular Carcinoma

Authors: Kainan Zhang, Hui Liu, Mengsi Yu, Hui Zhao, Ning Yang, Xiaojuan Bi, Li Sun, Renyong Lin, Guodong Lü

Journal: Front Oncol

PubMed ID: 34722323

Doi: 10.3389/fonc.2021.785394

Products & Services: DNA Sequencing

Strategy for Producing the High-Quality Glycopeptide Antibiotic A82846B in Based on the CRISPR-Cas12a System

Authors: Hui Qian, Wei Wei, Xin-Ai Chen, Xiao-Ting Mo, Mei Ge, Qing-Wei Zhao, Yong-Quan Li

Journal: ACS Synth Biol

PubMed ID: 34628852

Doi: 10.1021/acssynbio.1c00317

Products & Services: DNA Sequencing

Development of Neutralizing Multimeric Nanobody Constructs Directed against IL-13: From Immunization to Lead Optimization

Authors: Philippe J-L Y Gevenois, Pieter De Pauw, Steve Schoonooghe, Cédric Delporte, Thami Sebti, Karim Amighi, Serge Muyldermans, Nathalie Wauthoz

Journal: J Immunol

PubMed ID: 34645688

Doi: 10.4049/jimmunol.2100250

Products & Services: DNA Sequencing

Development of Rapid and Visual Nucleic Acid Detection Methods towards Four Serotypes of Human Adenovirus Species B Based on RPA-LF Test

Authors: Yong Qi, Wei Li, Xiaoling Li, Wanpeng Shen, Jinhai Zhang, Jiameng Li, Ruichen Lv, Nianhong Lu, Liqiang Zong, Susu Zhuang, Qiyuan Gui, Dongming Zhou, Jing Li, Yingjia Xu, Hongbing Shen, Yuexi Li

Journal: Biomed Res Int

PubMed ID: 34646888

Doi: 10.1155/2021/9957747

Products & Services: DNA Sequencing

Antigenicity and immunogenicity of recombinant proteins comprising African swine fever virus proteins p30 and p54 fused to a cell-penetrating peptide

Authors: Guanglei Zhang, Wei Liu, Zhan Gao, Sicheng Yang, Guangqing Zhou, Yanyan Chang, Yunyun Ma, Xiaxia Liang, Junjun Shao, Huiyun Chang

Journal: Int Immunopharmacol

PubMed ID: 34715492

Doi: 10.1016/j.intimp.2021.108251

Products & Services: Custom Vector Construction

Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

Authors: J J David Ho, Tyler A Cunningham, Paola Manara, Caroline A Coughlin, Artavazd Arumov, Evan R Roberts, Ashanti Osteen, Preet Kumar, Daniel Bilbao, Jonathan R Krieger, Stephen Lee, Jonathan H Schatz

Journal: Cell Rep

PubMed ID: 34644561

Doi: 10.1016/j.celrep.2021.109806

Products & Services: Custom Vector Construction

Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus)

Authors: Ting Liu, Ti-Lin Yi, Dai-Qin Yang, Ya-Xiong Tao

Journal: Gen Comp Endocrinol

PubMed ID: 34653433

Doi: 10.1016/j.ygcen.2021.113928

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Aquaglyceroporins and orthodox aquaporins in human adipocytes

Authors: Peng Huang, Jesper S Hansen, Karim H Saba, Anna Bergman, Florentina Negoita, Pontus Gourdon, Anna Hagström-Andersson, Karin Lindkvist-Petersson

Journal: Biochim Biophys Acta Biomembr

PubMed ID: 34627746

Doi: 10.1016/j.bbamem.2021.183795

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Characterization of SARS-CoV-2 Variants N501YV1 and N501YV2 Spike on Viral Infectivity

Authors: Haijun Tang, Long Gao, Zhao Wu, Fang Meng, Xin Zhao, Yun Shao, Xiaohua Shi, Shigang Qiao, Jianzhong An, Xiaohong Du, F Xiao-Feng Qin

Journal: Front Cell Infect Microbiol

PubMed ID: 34722330

Doi: 10.3389/fcimb.2021.720357

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Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay

Authors: Nina Svensen, Susan Wyllie, David W Gray, Manu De Rycker

Journal: PLoS Negl Trop Dis

PubMed ID: 34634052

Doi: 10.1371/journal.pntd.0009870

Products & Services: Codon Optimization

Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

Authors: Muhammad Faheem, Napoleão Fonseca Valadares, José Brandão-Neto, Dom Bellini, Patrick Collins, Nicholas M Pearce, Louise Bird, Juliana Roberta Torini, Raymond Owens, Humberto DMuniz Pereira, Frank Von Delft, João Alexandre Ribeiro Gonçalves Barbosa

Journal: Biochem J

PubMed ID: 34529035

Doi: 10.1042/BCJ20210041

Products & Services: Codon Optimization

Downregulation of the Tem1 GTPase by Amn1 after cytokinesis involves both nuclear import and SCF-mediated degradation

Authors: Alain Devault, Simonetta Piatti

Journal: J Cell Sci

PubMed ID: 34518877

Doi: 10.1242/jcs.258972

Products & Services: Recombinant Proteins

Antibody-Mediated Targeting of Antigens to Intestinal Aminopeptidase N Elicits Gut IgA Responses in Pigs

Authors: Hans Van der Weken, Raquel Sanz Garcia, Niek N Sanders, Eric Cox, Bert Devriendt

Journal: Front Immunol

PubMed ID: 34721427

Doi: 10.3389/fimmu.2021.753371

Products & Services: Gene Synthesis

GM-CSF Nitration Is a New Driver of Myeloid Suppressor Cell Activity in Tumors

Authors: Bianca Calì, Andrielly H R Agnellini, Chiara Cioccarelli, Ricardo Sanchez-Rodriguez, Andrea Predonzani, Giulia Ilaria Toffolo, Antonella Viola, Vincenzo Bronte, Giorgio Arrigoni, Francesco Zonta, Laura Albertoni, Claudia Mescoli, Ilaria Marigo, Barbara Molon

Journal: Front Immunol

PubMed ID: 34675917

Doi: 10.3389/fimmu.2021.718098

Products & Services: Gene Synthesis

Yeast-expressed recombinant SARS-CoV-2 receptor binding domain RBD203-N1 as a COVID-19 protein vaccine candidate

Authors: Wen-Hsiang Chen, Jeroen Pollet, Ulrich Strych, Jungsoon Lee, Zhuyun Liu, Rakhi Tyagi Kundu, Leroy Versteeg, Maria Jose Villar, Rakesh Adhikari, Junfei Wei, Cristina Poveda, Brian Keegan, Aaron Oakley Bailey, Yi-Lin Chen, Portia M Gillespie, Jason T Kimata, Bin Zhan, Peter J Hotez, Maria Elena Bottazzi

Journal: Protein Expr Purif

PubMed ID: 34688919

Doi: 10.1016/j.pep.2021.106003

Products & Services: Custom DNA/RNA Oligos

Cytotopic (Cyto-) IL-15 as a New Immunotherapy for Prostate Cancer: Recombinant Production in and Purification

Authors: Ana M Esteves, Efthymia Papaevangelou, Dorota Smolarek, Prokar Dasgupta, Christine Galustian

Journal: Front Mol Biosci

PubMed ID: 34778376

Doi: 10.3389/fmolb.2021.755764

Products & Services: Proteins, Expression, Isolation and Analysis

An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble and During Aging

Authors: Maria Lucia Pigazzini, Mandy Lawrenz, Anca Margineanu, Gabriele S Kaminski Schierle, Janine Kirstein

Journal: Front Mol Neurosci

PubMed ID: 34720872

Doi: 10.3389/fnmol.2021.721749

Products & Services: Gene Synthesis

N-Terminal Modification of Gly-His-Tagged Proteins with Azidogluconolactone

Authors: Karl D Brune, Ilva Liekniņa, Grigorij Sutov, Alexander R Morris, Dejana Jovicevic, Gints Kalniņš, Andris Kazāks, Rihards Kluga, Sabine Kastaljana, Anna Zajakina, Juris Jansons, Dace Skrastiņa, Karīna Spunde, Alexander A Cohen, Pamela J Bjorkman, Howard R Morris, Edgars Suna, Kaspars Tārs

Journal: Chembiochem

PubMed ID: 34520613

Doi: 10.1002/cbic.202100381

Products & Services: Peptide Synthesis

The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia

Authors: Chun-Hao Su, Wei-Ju Liao, Wei-Chi Ke, Ruey-Bing Yang, Woan-Yuh Tarn

Journal: iScience

PubMed ID: 34816104

Doi: 10.1016/j.isci.2021.103368

Products & Services: Recombinant Proteins

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

Authors: Francisco S Mesquita, Laurence Abrami, Oksana Sergeeva, Priscilla Turelli, Enya Qing, Béatrice Kunz, Charlène Raclot, Jonathan Paz Montoya, Luciano A Abriata, Tom Gallagher, Matteo Dal Peraro, Didier Trono, Giovanni D'Angelo, F Gisou van der Goot

Journal: Dev Cell

PubMed ID: 34599882

Doi: 10.1016/j.devcel.2021.09.016

Products & Services: Recombinant Proteins

The GPR171 pathway suppresses T cell activation and limits antitumor immunity

Authors: Yuki Fujiwara, Robert J Torphy, Yi Sun, Emily N Miller, Felix Ho, Nicholas Borcherding, Tuoqi Wu, Raul M Torres, Weizhou Zhang, Richard D Schulick, Yuwen Zhu

Journal: Nat Commun

PubMed ID: 34615877

Doi: 10.1038/s41467-021-26135-9

Products & Services: Peptide Synthesis

Next generation of tumor-activating type I IFN enhances anti-tumor immune responses to overcome therapy resistance

Authors: Xuezhi Cao, Yong Liang, Zhenxiang Hu, Huiyu Li, Jiaming Yang, Eric J Hsu, Jiankun Zhu, Jin Zhou, Yang-Xin Fu

Journal: Nat Commun

PubMed ID: 34620867

Doi: 10.1038/s41467-021-26112-2

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Structural determinants of the integrin transmembrane domain required for bidirectional signal transmission across the cell membrane

Authors: Zhengli Wang, Jieqing Zhu

Journal: J Biol Chem

PubMed ID: 34678312

Doi: 10.1016/j.jbc.2021.101318

Products & Services: Proteins, Expression, Isolation and Analysis

Complete three-dimensional structures of the Lon protease translocating a protein substrate

Authors: Shanshan Li, Kan-Yen Hsieh, Chiao-I Kuo, Szu-Hui Lee, Grigore D Pintilie, Kaiming Zhang, Chung-I Chang

Journal: Sci Adv

PubMed ID: 34652947

Doi: 10.1126/sciadv.abj7835

Products & Services: Proteins, Expression, Isolation and Analysis

Programmable nano-reactors for stochastic sensing

Authors: Wendong Jia, Chengzhen Hu, Yuqin Wang, Yuming Gu, Guangrui Qian, Xiaoyu Du, Liying Wang, Yao Liu, Jiao Cao, Shanyu Zhang, Shuanghong Yan, Panke Zhang, Jing Ma, Hong-Yuan Chen, Shuo Huang

Journal: Nat Commun.

PubMed ID: 34608151

Doi: 10.1038/s41467-021-26054-9

Products & Services: Single-Stranded DNA Synthesis

Structural basis of the P4B ATPase lipid flippase activity

Authors: Lin Bai, Bhawik K Jain, Qinglong You, H Diessel Duan, Mehmet Takar, Todd R Graham, Huilin Li

Journal: Nat Commun

PubMed ID: 34645814

Doi: 10.1038/s41467-021-26273-0

Products & Services: Proteins, Expression, Isolation and Analysis

Does poor glycaemic control affect the immunogenicity of the COVID-19 vaccination in patients with type 2 diabetes: The CAVEAT study

Authors: Raffaele Marfella, Nunzia D'Onofrio, Celestino Sardu, Lucia Scisciola, Paolo Maggi, Nicola Coppola, Ciro Romano, Vincenzo Messina, Fabrizio Turriziani, Mario Siniscalchi, Mauro Maniscalco, Marco Boccalatte, Giovanni Napolitano, Luigi Salemme, Ludovica Vittoria Marfella, Eugenio Basile, Maria Vittoria Montemurro, Carmela Papa, Francesco Frascaria, Antonio Papa, Ferdinando Russo, Virginia Tirino, Gianpaolo Papaccio, Marilena Galdiero, Ferdinando Carlo Sasso, Michelangela Barbieri, Maria Rosaria Rizzo, Maria Luisa Balestrieri, Italo Francesco Angelillo, Claudio Napoli, Giuseppe Paolisso

Journal: Diabetes Obes Metab

PubMed ID: 34494705

Doi: 10.1111/dom.14547

Products & Services: Serology SARS-Cov-2 detection kits

Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes

Authors: Yingjuan J Lu, Leroy W Wheeler, Haiyan Chu, Paul J Kleindl, Michael Pugh, Fei You, Satish Rao, Gabriela Garcia, Henry Y Wu, Andre P da Cunha, Richard Johnson, Elaine Westrick, Vicky Cross, Alex Lloyd, Christina Dircksen, Patrick J Klein, Iontcho R Vlahov, Philip S Low, Christopher P Leamon

Journal: Cell Rep Med

PubMed ID: 34755134

Doi: 10.1016/j.xcrm.2021.100422

Products & Services: Mammalian Expression

PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

Authors: Sophie Sluysmans, Isabelle Méan, Tong Xiao, Amina Boukhatemi, Flavio Ferreira, Lionel Jond, Annick Mutero, Christopher J Chang, Sandra Citi

Journal: Mol Biol Cell

PubMed ID: 34613798

Doi: 10.1091/mbc.E21-07-0355

Products & Services: Molecular Biology Tools

Comprehensive Analysis of Transcriptome-wide mA Methylome Upon Beta2 Toxin Exposure in Porcine Intestinal Epithelial Cells by mA Sequencing

Authors: Juanli Zhang, Qiaoli Yang, Jiaojiao Yang, Xiaoli Gao, Ruirui Luo, Xiaoyu Huang, Zunqiang Yan, Pengfei Wang, Wei Wang, Kaihui Xie, Bo Zhang, Shuangbao Gun

Journal: Front Genet

PubMed ID: 34737761

Doi: 10.3389/fgene.2021.689748

Products & Services: Proteins, Expression, Isolation and Analysis

Two Novel Hydroxymethylbilane Synthase Splicing Mutations Predispose to Acute Intermittent Porphyria

Authors: Yanping Zhang, Han Xiao, Qiuhong Xiong, Changxin Wu, Ping Li

Journal: Int J Mol Sci

PubMed ID: 34681668

Doi: 10.3390/ijms222011008

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Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma

Authors: Mari K Halle, Aishwarya Sundaresan, Jianqing Zhang, Chandra Sekhar Pedamallu, Vinodh Srinivasasainagendra, Jessica Blair, Dewey Brooke, Bjørn I Bertelsen, Kathrine Woie, Sadeep Shrestha, Hemant Tiwari, Yick Fu Wong, Camilla Krakstad, Akinyemi I Ojesina

Journal: NPJ Genom Med

PubMed ID: 34620846

Doi: 10.1038/s41525-021-00244-2

Products & Services: Gene Synthesis

Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice

Authors: Koki Yanazawa, Takehito Sugasawa, Kai Aoki, Takuro Nakano, Yasushi Kawakami, Kazuhiro Takekoshi

Journal: PeerJ

PubMed ID: 34721976

Doi: 10.7717/peerj.12285

Products & Services: Plasmid DNA Preparation

Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells

Authors: Motahareh Arjomandnejad, Katelyn Sylvia, Meghan Blackwood, Thomas Nixon, Qiushi Tang, Manish Muhuri, Alisha M Gruntman, Guangping Gao, Terence R Flotte, Allison M Keeler

Journal: Mol Ther Methods Clin Dev

PubMed ID: 34853797

Doi: 10.1016/j.omtm.2021.10.010

Products & Services: Peptide Synthesis

Rational engineering of a functional CpG-free ITR for AAV gene therapy

Authors: Xiufang Pan, Yongping Yue, Maria Boftsi, Lakmini P Wasala, Ngoc Tam Tran, Keqing Zhang, David J Pintel, Phillip W L Tai, Dongsheng Duan

Journal: Gene Ther

PubMed ID: 34611321

Doi: 10.1038/s41434-021-00296-0

Products & Services: Recombinant Proteins

Limited impact of Delta variantâ€™s mutations in the effectiveness of neutralization conferred by natural infection or COVID-19 vaccines in a Latino population

Authors: Carlos A Sariol, Crisanta Serrano-Collazo, Edwin J Ortiz, Petraleigh Pantoja, Lorna Cruz, Teresa Arana, Dianne Atehortua, Christina Pabon-Carrero, Ana M Espino

Journal: medrxiv

PubMed ID: 34729566

Doi: 10.1101/2021.10.25.21265422

Products & Services: Recombinant Proteins

Identification and evaluation of an appropriate housekeeping gene for real time gene profiling of hepatocellular carcinoma cells cultured in three dimensional scaffold

Authors: Anjana Kaveri Badekila, Praveen Rai, Sudarshan Kini

Journal: Mol Biol Rep

PubMed ID: 34665400

Doi: 10.1007/s11033-021-06830-y

Products & Services: Molecular Biology Tools

Effect of Structural Changes Induced by Deletion of 54FLRAPSWF61 Sequence in αB-Crystallin on Chaperone Function and Anti-Apoptotic Activity

Authors: Sundararajan Mahalingam, Srabani Karmakar 1ORCID, Puttur Santhoshkumar, Krishna K. Sharma

Journal: International Journal of Molecular Sciences

PubMed ID: 34639110

Doi: 10.3390/ijms221910771

Products & Services: Proteins, Expression, Isolation and Analysis

Cytochalasin B-induced membrane vesicles from human mesenchymal stem cells overexpressing TRAIL, PTEN and IFN-β1 can kill carcinoma cancer cells

Authors: Daria S Chulpanova, Zarema E Gilazieva, Elvira R Akhmetzyanova, Sevindzh K Kletukhina, Albert A Rizvanov, Valeriya V Solovyeva

Journal: Tissue Cell

PubMed ID: 34678531

Doi: 10.1016/j.tice.2021.101664

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