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Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation

Authors: Yonghong Luo, Yanhong Guo, Huilun Wang, Minzhi Yu, Kristen Hong, Dan Li, Ruiting Li, Bo Wen, Die Hu, Lin Chang, Jifeng Zhang, Bo Yang, Duxin Sun, Anna S Schwendeman, Y Eugene Chen

Journal: EBioMedicine

PubMed ID: 34879325

Doi: 10.1016/j.ebiom.2021.103725

Products & Services: Peptide Synthesis

Oxidation of Various Kraft Lignins with a Bacterial Laccase Enzyme

Authors: Sebastian A Mayr, Raditya Subagia, Renate Weiss, Nikolaus Schwaiger, Hedda K Weber, Johannes Leitner, Doris Ribitsch, Gibson S Nyanhongo, Georg M Guebitz

Journal: Int J Mol Sci

PubMed ID: 34884966

Doi: 10.3390/ijms222313161

Products & Services: Stable Cell Lines

Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens

Authors: Ryuta Uraki, Masaki Imai, Mutsumi Ito, Hiroaki Shime, Mizuyu Odanaka, Moe Okuda, Yoshihiro Kawaoka, Sayuri Yamazaki

Journal: PLoS Pathog

PubMed ID: 34882757

Doi: 10.1371/journal.ppat.1010085

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A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation

Authors: Christopher E Smith, Yien Che Tsai, Yu-He Liang, Domarin Khago, Jennifer Mariano, Jess Li, Sergey G Tarasov, Emma Gergel, Borong Tsai, Matthew Villaneuva, Michelle E Clapp, Valentin Magidson, Raj Chari, R Andrew Byrd, Xinhua Ji, Allan M Weissman

Journal: PLoS Biol

PubMed ID: 34879065

Doi: 10.1371/journal.pbio.3001474

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Division of labor between SOS and PafBC in mycobacterial DNA repair and mutagenesis

Authors: Oyindamola O Adefisayo, Pierre Dupuy, Astha Nautiyal, James M Bean, Michael S Glickman

Journal: Nucleic Acids Res

PubMed ID: 34871411

Doi: 10.1093/nar/gkab1169

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Development and characterization of efficient xylose utilization strains of Zymomonas mobilis

Authors: Jiyun Lou, Jingwen Wang, Yongfu Yang, Qing Yang, Runxia Li, Mimi Hu, Qiaoning He, Jun Du, Xia Wang, Mian Li, Shihui Yang

Journal: Biotechnol Biofuels

PubMed ID: 34863266

Doi: 10.1186/s13068-021-02082-x

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GR-mediated transcriptional regulation of mA metabolic genes contributes to diet-induced fatty liver in hens

Authors: Yue Feng, Yanlin Li, Wenduo Jiang, Yun Hu, Yimin Jia, Ruqian Zhao

Journal: J Anim Sci Biotechnol

PubMed ID: 34872591

Doi: 10.1186/s40104-021-00642-7

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The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost

Authors: Paolo Mesén-Ramírez, Bärbel Bergmann, Mourad Elhabiri, Lei Zhu, Heidrun von Thien, Carolina Castro-Peña, Tim-Wolf Gilberger, Elisabeth Davioud-Charvet, Zbynek Bozdech, Anna Bachmann, Tobias Spielmann

Journal: Cell Host Microbe

PubMed ID: 34863371

Doi: 10.1016/j.chom.2021.11.002

Products & Services: Stable Cell Lines

The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target

Authors: Gergely Rona, Andras Zeke, Bearach Miwatani-Minter, Maren de Vries, Ramanjit Kaur, Austin Schinlever, Sheena Faye Garcia, Hailey V Goldberg, Hui Wang, Thomas R Hinds, Fabrice Bailly, Ning Zheng, Philippe Cotelle, Didier Desmaële, Nathaniel R Landau, Meike Dittmann, Michele Pagano

Journal: Cell Death Differ

PubMed ID: 34862481

Doi: 10.1038/s41418-021-00900-1

Products & Services: Codon Optimization

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

Authors: Ioanna A Rota, Adam E Handel, Stefano Maio, Fabian Klein, Fatima Dhalla, Mary E Deadman, Stanley Cheuk, Joseph A Newman, Yale S Michaels, Saulius Zuklys, Nicolas Prevot, Philip Hublitz, Philip D Charles, Athina Soragia Gkazi, Eleni Adamopoulou, Waseem Qasim, Edward Graham Davies, Imelda Hanson, Alistair T Pagnamenta, Carme Camps, Helene M Dreau, Andrea White, Kieran James, Roman Fischer, Opher Gileadi, Jenny C Taylor, Tudor Fulga, B Christoffer Lagerholm, Graham Anderson, Erdinc Sezgin, Georg A Holländer

Journal: Sci Adv

PubMed ID: 34860543

Doi: 10.1126/sciadv.abj9247

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

Authors: Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde

Journal: Commun Biol

PubMed ID: 34853399

Doi: 10.1038/s42003-021-02866-9

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Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

Authors: Elif Karaaslan, Nesibe Selma Çetin, Merve Kalkan-Yazıcı, Sevde Hasanoğlu, Faruk Karakeçili, Aykut Özdarendeli, Ahmet Kalkan, Ali Osman Kılıç, Mehmet Ziya Doymaz

Journal: PLoS Negl Trop Dis

PubMed ID: 34851958

Doi: 10.1371/journal.pntd.0009973

Products & Services: Bacterial Expression

Dynamic Distribution of HIG2A between the Mitochondria and the Nucleus in Response to Hypoxia and Oxidative Stress

Authors: Celia Salazar, Miriam Barros, Alvaro A Elorza, Lina María Ruiz

Journal: Int J Mol Sci

PubMed ID: 35008815

Doi: 10.3390/ijms23010389

Products & Services: Plasmid DNA Preparation

Glycoside Hydrolase family 30 harbors fungal subfamilies with distinct polysaccharide specificities

Authors: Xinxin Li, Dimitrios Kouzounis, Mirjam A Kabel, Ronald P de Vries, Adiphol Dilokpimol

Journal: N Biotechnol

PubMed ID: 34952234

Doi: 10.1016/j.nbt.2021.12.004

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Cloning, Expression and Inhibitory Effects on Lewis Lung Carcinoma Cells of rAj-Tspin from Sea Cucumber ()

Authors: Rong Qiao, Rong Xiao, Zhong Chen, Jingwei Jiang, Chenghua Yuan, Shuxiang Ning, Jihong Wang, Zunchun Zhou

Journal: Molecules

PubMed ID: 35011462

Doi: 10.3390/molecules27010229

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Progressing Ultragreen, Energy-Efficient Biobased Depolymerization of Poly(ethylene terephthalate) via Microwave-Assisted Green Deep Eutectic Solvent and Enzymatic Treatment

Authors: Olivia A Attallah, Muhammad Azeem, Efstratios Nikolaivits, Evangelos Topakas, Margaret Brennan Fournet

Journal: Polymers (Basel)

PubMed ID: 35012131

Doi: 10.3390/polym14010109

Products & Services: Bacterial Expression

Novel reverse genetics of genotype I and III Japanese encephalitis viruses assembled through transformation associated recombination in yeast: The reporter viruses expressing a green fluorescent protein for the antiviral screening assay

Authors: Chenxi Li, Xuan Chen, Yanyang Zhou, Jingbo Hu, Xinjie Wang, Yanhua Li

Journal: Antiviral Res

PubMed ID: 34973281

Doi: 10.1016/j.antiviral.2021.105233

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A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern

Authors: Shahbaz Ahmed, Mohammad Suhail Khan, Savitha Gayathri, Randhir Singh, Sahil Kumar, Unnatiben Rajeshbhai Patel, Sameer Kumar Malladi, Raju S Rajmani, Petrus Jansen van Vuren, Shane Riddell, Sarah Goldie, Nidhi Girish, Poorvi Reddy, Aditya Upadhyaya, Suman Pandey, Samreen Siddiqui, Akansha Tyagi, Sujeet Jha, Rajesh Pandey, Oyahida Khatun, Rohan Narayan, Shashank Tripathi, Alexander J McAuley, Nagendrakumar Balasubramanian Singanallur, Seshadri S Vasan, Rajesh P Ringe, Raghavan Varadarajan

Journal: Front Immunol

PubMed ID: 34956193

Doi: 10.3389/fimmu.2021.765211

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Implications of Quenching-to-Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye-Labeled Nanoparticles

Authors: Guangze Yang+ , Yun Liu+ , Yue Hui, Tengjisi, Dong Chen, David A. Weitz, and Chun-Xia Zhao

Journal: ANGEWANDTE CHEMIE

Doi: doi.org/10.1002/anie.202101730

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Circular RNA circRNA_0082835 promotes progression and lymphatic metastasis of primary melanoma by sponging microRNA miRNA-429

Authors: Yute Sun, Zuoqiong Hou, Binlin Luo, Chujun Li, Jinfang Liu, Jianlan Liu, Jian Tang, Gang Yao

Journal: Bioengineered

PubMed ID: 34288815

Doi: 10.1080/21655979.2021.1953822

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Long non-coding RNA SNHG5 regulates ulcerative colitis via microRNA-375 / Janus kinase-2 axis

Authors: Hui Li, Ji Xuan, Wei Zhang, Zhentao An, Xinyu Fan, Min Lu, Yaozhou Tian

Journal: Bioengineered

PubMed ID: 34334085

Doi: 10.1080/21655979.2021.1953219

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Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application

Authors: Nattihda Parakasikron, Chatchai Chaotham, Pithi Chanvorachote, Chanida Vinayanuwattikun, Visarut Buranasudja, Pornchanok Taweecheep, Kannika Khantasup

Journal: Drug Deliv

PubMed ID: 34236266

Doi: 10.1080/10717544.2021.1943055

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microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis

Authors: Zixin Hou, Ji Chen, Huan Yang, Xiaoling Hu, Fengrui Yang

Journal: Adipocyte

PubMed ID: 34311651

Doi: 10.1080/21623945.2021.1938829

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Mesenchymal Stem/Stromal Cells Overexpressing CXCR4 Revealed Enhanced Migration: A Lesson Learned from the Pathogenesis of WHIM Syndrome

Authors: Hamid Reza Bidkhori, Ahmad Reza Bahrami, Moein Farshchian, Asieh Heirani-Tabasi, Mahdi Mirahmadi, Halimeh Hasanzadeh, Naghmeh Ahmadiankia, Reza Faridhosseini, Mahtab Dastpak, Arezoo Gowhari Shabgah, Maryam M Matin

Journal: Cell Transplant

PubMed ID: 34807749

Doi: 10.1177/09636897211054498

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Targeted therapy of irritable bowel syndrome with anti-inflammatory cytokines

Authors: Sunil Kumar, Priyanka Singh, Awanish Kumar

Journal: Clin J Gastroenterol

PubMed ID: 34862947

Doi: 10.1007/s12328-021-01555-8

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Long non-coding RNA H19 protects against intracerebral hemorrhage injuries via regulating microRNA-106b-5p/acyl-CoA synthetase long chain family member 4 axis

Authors: Bing Chen, Haoran Wang, Chenglin Lv, Chongdan Mao, Yuguang Cui

Journal: Bioengineered

PubMed ID: 34288826

Doi: 10.1080/21655979.2021.1951070

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Rapid test to assess the escape of SARS-CoV-2 variants of concern

Authors: Jacob T Heggestad, Rhett J Britton, David S Kinnamon, Simone A Wall, Daniel Y Joh, Angus M Hucknall, Lyra B Olson, Jack G Anderson, Anna Mazur, Cameron R Wolfe, Thomas H Oguin, Bruce A Sullenger, Thomas W Burke, Bryan D Kraft, Gregory D Sempowski, Christopher W Woods, Ashutosh Chilkoti

Journal: Sci Adv

PubMed ID: 34860546

Doi: 10.1126/sciadv.abl7682

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Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond

Authors: Qiuping Zhang, Yanni Wang, Zongyuan Wang, Eyad Abdulwhab Hamoud Mohammed, Quanyi Zhao, Dian He, Zhen Wang

Journal: Bioorg Chem

PubMed ID: 34902645

Doi: 10.1016/j.bioorg.2021.105542

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sp nov, a novel phenylacetic acid degrading bacterium isolated from sludge

Authors: Fa-Hu Pang, Hui-Ying Yang, Jie Sun, Xing Yu, Hao Zhang

Journal: Int J Syst Evol Microbiol

PubMed ID: 34878373

Doi: 10.1099/ijsem.0.005144

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KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

Authors: Michiko Shimoda, Yuanzhi Lyu, Kang-Hsin Wang, Ashish Kumar, Hiroki Miura, Joshua F Meckler, Ryan R Davis, Chanikarn Chantarasrivong, Chie Izumiya, Clifford G Tepper, Ken-Ichi Nakajima, Joseph Tuscano, Gustavo Barisone, Yoshihiro Izumiya

Journal: Commun Biol

PubMed ID: 34857874

Doi: 10.1038/s42003-021-02853-0

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A unique flavoenzyme operates in ubiquinone biosynthesis in photosynthesis-related eukaryotes

Authors: Jing-Jing Xu, Xiao-Fan Zhang, Yan Jiang, Hang Fan, Jian-Xu Li, Chen-Yi Li, Qing Zhao, Lei Yang, Yong-Hong Hu, Cathie Martin, Xiao-Ya Chen

Journal: Sci Adv

PubMed ID: 34878842

Doi: 10.1126/sciadv.abl3594

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Population genetics of cycas necrotic stunt virus and the development of multiplex RT-PCR diagnostics

Authors: Cullen M Shaffer, David C Michener, Nastassia B Vlasava, Henry Chotkowski, Ioannis E Tzanetakis

Journal: Virus Res

PubMed ID: 34906655

Doi: 10.1016/j.virusres.2021.198655

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Physicochemical and molecular transformation of novel functional peptides from Baijiu

Authors: Wei Jia, An Du, Xiaojun Dong, Zibian Fan, Duimin Zhang, Ruihong Wang, Lin Shi

Journal: Food Chem

PubMed ID: 34954580

Doi: 10.1016/j.foodchem.2021.131894

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ACE2-IgG1 fusions with improved and activity against SARS-CoV-2

Authors: Naoki Iwanaga, Laura Cooper, Lijun Rong, Nicholas J Maness, Brandon Beddingfield, Zhongnan Qin, Jackelyn Crabtree, Ralph A Tripp, Haoran Yang, Robert Blair, Sonia Jangra, Adolfo García-Sastre, Michael Schotsaert, Chandra Sruti, James E Robinson, Akhilesh Srivastava, Felix Rabito, Xuebin Qin, Jay K Kolls

Journal: iScience

PubMed ID: 34957381

Doi: 10.1016/j.isci.2021.103670

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Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells

Authors: Xiaochen Wang, Yaochuan Mi, Wei He, Xiaona Hu, Shuo Yang, Lu Zhao, Yanyang Zhang, Binhong Wen

Journal: Bioengineered

PubMed ID: 33818278

Doi: 10.1080/21655979.2021.1905259

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WHO international standard for SARS-CoV-2 antibodies to determine markers of protection

Authors: Feng Zhu, Thomas Althaus, Chee Wah Tan, Alizée Costantini, Wan Ni Chia, Nguyen Van Vinh Chau, Le Van Tan, Giada Mattiuzzo, Nicola J Rose, Eric Voiglio, Lin-Fa Wang

Journal: Lancet Microbe

PubMed ID: 34901897

Doi: 10.1016/S2666-5247(21)00307-4

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Plasmonically Enhanced Ultrasensitive Epitope-Specific Serologic Assay for COVID-19

Authors: Zheyu Wang, Jeremiah J Morrissey, Lin Liu, Yixuan Wang, Qingjun Zhou, Rajesh R Naik, Srikanth Singamaneni

Journal: Anal Chem

PubMed ID: 34935364

Doi: 10.1021/acs.analchem.1c03676

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Novel nanostructure-coupled biosensor platform for one-step high-throughput quantification of serum neutralizing antibody after COVID-19 vaccination

Authors: Liping Huang, Ying Li, Changyou Luo, Youqian Chen, Nadia Touil, Hicham-El Annaz, Shaoqi Zeng, Tang Dang, Jiawei Liang, Wenjun Hu, Hao Xu, Jiasheng Tu, Lin Wang, Yan Shen, Gang L Liu

Journal: Biosens Bioelectron

PubMed ID: 34920226

Doi: 10.1016/j.bios.2021.113868

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Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin

Authors: Yan Wang, Zhiqiang Cheng, Jing Xu, Meina Lai, Liming Liu, Min Zuo, Lin Dang

Journal: Bioengineered

PubMed ID: 34076564

Doi: 10.1080/21655979.2021.1924544

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The arthrospore-related gene Acaxl2 is involved in cephalosporin C production in industrial Acremonium chrysogenum by the regulatory factors AcFKH1 and CPCR1

Authors: Yan Xu, Ling Liu, Zhen Chen, Xiwei Tian, Ju Chu

Journal: J Biotechnol

PubMed ID: 34954288

Doi: 10.1016/j.jbiotec.2021.12.011

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Local Charge Distributions, Electric Dipole Moments, and Local Electric Fields Influence Reactivity Patterns and Guide Regioselectivities in α-Ketoglutarate-Dependent Non-heme Iron Dioxygenases

Authors: Sam P de Visser, Gourab Mukherjee, Hafiz Saqib Ali, Chivukula V Sastri

Journal: Acc Chem Res

PubMed ID: 34915695

Doi: 10.1021/acs.accounts.1c00538

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Chlorogenic Acid-Induced Gut Microbiota Improves Metabolic Endotoxemia

Authors: Xiaolin Ye, Yang Liu, Jiajin Hu, Yanyan Gao, Yanan Ma, Deliang Wen

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34975748

Doi: 10.3389/fendo.2021.762691

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SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

Authors: Sandile Cele, Laurelle Jackson, David S Khoury, Khadija Khan, Thandeka Moyo-Gwete, Houriiyah Tegally, James Emmanuel San, Deborah Cromer, Cathrine Scheepers, Daniel Amoako, Farina Karim, Mallory Bernstein, Gila Lustig, Derseree Archary, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Shi-Hsia Hwa, Jennifer Giandhari, Jonathan M Blackburn, Bernadett I Gosnell, Salim S Abdool Karim, Willem Hanekom, Anne von Gottberg, Jinal Bhiman, Richard J Lessells, Mahomed-Yunus S Moosa, Miles P Davenport, Tulio de Oliveira, Penny L Moore, Alex Sigal

Journal: medrxiv

PubMed ID: 34909788

Doi: 10.1101/2021.12.08.21267417

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Vascular endothelial growth factor-c regulates hematopoietic stem cell fate in the dorsal aorta

Authors: Rebecca K Schiavo, Owen J Tamplin

Journal: Development

PubMed ID: 34919128

Doi: 10.1242/dev.199498

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LncRNA-IRAR-mediated regulation of insulin receptor transcripts in Drosophila melanogaster during nutritional stress

Authors: Jie Chen, Yuantai Huang, Guojun Qi

Journal: Insect Mol Biol

PubMed ID: 34923706

Doi: 10.1111/imb.12756

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MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma

Authors: Hui Liu, Zuofei Chi, Hong Jin, Wei Yang

Journal: Bioengineered

PubMed ID: 33944676

Doi: 10.1080/21655979.2021.1920325

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Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C-type lectin receptor Langerin

Authors: Lydia Bellmann, Helen Strandt, Claudia Zelle-Rieser, Daniela Ortner, Christoph H Tripp, Sandra Schmid, Julia Rühl, Giuseppe Cappellano, Sandra Schaffenrath, Anastasia Prokopi, Sarah Spoeck, Athanasios Seretis, Barbara Del Frari, Stephan Sigl, Johanna Krapf, Christine Heufler, Tibor Keler, Christian Münz, Nikolaus Romani, Patrizia Stoitzner

Journal: Eur J Immunol

PubMed ID: 34932821

Doi: 10.1002/eji.202149670

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Characterization and expression analysis of the SPL gene family during floral development and abiotic stress in pecan ()

Authors: Min Wang, Zhenghai Mo, Ruozhu Lin, Cancan Zhu

Journal: PeerJ

PubMed ID: 34966577

Doi: 10.7717/peerj.12490

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Constructing DNA logic circuits based on the toehold preemption mechanism

Authors: Cuicui Xing, Xuedong Zheng, Qiang Zhang

Journal: RSC Adv

PubMed ID: 35424506

Doi: 10.1039/d1ra08687a

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Novel Tyrosine Kinase-Mediated Phosphorylation With Dual Specificity Plays a Key Role in the Modulation of Physiology and Virulence

Authors: Sashi Kant, Vijay Pancholi

Journal: Front Microbiol

PubMed ID: 34950110

Doi: 10.3389/fmicb.2021.689246

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