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Penetration of the SARS-CoV-2 Spike Protein across the Blood-Brain Barrier, as Revealed by a Combination of a Human Cell Culture Model System and Optical Biosensing

Authors: Dániel Petrovszki, Fruzsina R Walter, Judit P Vigh, Anna Kocsis, Sándor Valkai, Mária A Deli, András Dér

Journal: Biomedicines

PubMed ID: 35052867

Doi: 10.3390/biomedicines10010188

Products & Services: Monoclonal Antibody Services

Protection and Alleviated Inflammation Induced by Virus-like Particle Vaccines Containing MSP-8, MSP-9 and RAP1

Authors: Su-Hwa Lee, Ki-Back Chu, Hae-Ji Kang, Fu-Shi Quan

Journal: Vaccines (Basel)

PubMed ID: 35214662

Doi: 10.3390/vaccines10020203

Products & Services: Codon Optimization

Protection and Alleviated Inflammation Induced by Virus-like Particle Vaccines Containing MSP-8, MSP-9 and RAP1

Authors: Su-Hwa Lee, Ki-Back Chu, Hae-Ji Kang, Fu-Shi Quan

Journal: Vaccines (Basel)

PubMed ID: 35214662

Doi: 10.3390/vaccines10020203

Products & Services: Codon Optimization

Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations

Authors: Anju Jaiswal, D Dash, Rashmi Singh

Journal: Toxicol Appl Pharmacol

PubMed ID: 34998855

Doi: 10.1016/j.taap.2021.115861

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Multimerization of the GATA4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response

Authors: Satoshi Shimizu, Yoichi Sunagawa, Naruto Hajika, Natsumi Yorimitsu, Yasufumi Katanasaka, Masafumi Funamoto, Yusuke Miyazaki, Nurmila Sari, Kana Shimizu, Koji Hasegawa, Tatsuya Morimoto

Journal: Int J Biol Sci

PubMed ID: 35173540

Doi: 10.7150/ijbs.65664

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Porphyromonas gingivalis infection promotes inflammation via inhibition of the AhR signalling pathway in periodontitis

Authors: Ting Hao, Rui Zhang, Tian Zhao, Juan Wu, Wai Keung Leung, Jie Yang, Weibin Sun

Journal: Cell Prolif

PubMed ID: 36446468

Doi: 10.1111/cpr.13364

Products & Services: Protein and Antibody Isolation

Investigating Constraints Along the Plant Secretory Pathway to Improve Production of a SARS-CoV-2 Spike Vaccine Candidate

Authors: Emmanuel Margolin, Matthew Verbeek, Warren de Moor, Ros Chapman, Ann Meyers, Georgia Schäfer, Anna-Lise Williamson, Edward Rybicki

Journal: Front Plant Sci

PubMed ID: 35058959

Doi: 10.3389/fpls.2021.798822

Products & Services: Mammalian Expression

Myricetin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting the Active and Locking the Inactive Conformations

Authors: Mei Dang, Liangzhong Lim, Amrita Roy, Jianxing Song

Journal: ACS Omega

PubMed ID: 35097276

Doi: 10.1021/acsomega.1c05569

Products & Services: Recombinant Proteins

ROS-regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer

Authors: Jie Li, Cuimiao Zheng, Mingshuo Wang, Anna D Umano, Qingyuan Dai, Chunyu Zhang, Hua Huang, Qing Yang, Xianzhi Yang, Jingyi Lu, Wenfeng Pan, Bo Li, Shuzhong Yao, Chaoyun Pan

Journal: Oncogene

PubMed ID: 35039634

Doi: 10.1038/s41388-021-02149-x

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Heterologous Expression and Functional Characterization of CAP18 from

Authors: Mahla Nikpoor, Azadeh Lohrasbi-Nejad, Jafar Zolala

Journal: Rep Biochem Mol Biol

PubMed ID: 35291606

Doi: 10.52547/rbmb.10.4.622

Products & Services: Protein and Antibody Isolation

A combination of multiple autoantibodies is associated with the risk of Alzheimer's disease and cognitive impairment

Authors: Sung-Mi Shim, Young Ho Koh, Jong-Hoon Kim, Jae-Pil Jeon

Journal: Sci Rep

PubMed ID: 35079008

Doi: 10.1038/s41598-021-04556-2

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Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

Authors: Dhana G Gorasia, Ignacio Lunar Silva, Catherine A Butler, Maïalène Chabalier, Thierry Doan, Eric Cascales, Paul D Veith, Eric C Reynolds

Journal: Microbiol Spectr

PubMed ID: 35019767

Doi: 10.1128/spectrum.01602-21

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Activity-based protein profiling reveals dynamic substrate-specific cellulase secretion by saprotrophic basidiomycetes

Authors: Nicholas G S McGregor, Casper de Boer, Mikhaaeel Santos, Mireille Haon, David Navarro, Sybrin Schroder, Jean-Guy Berrin, Herman S Overkleeft, Gideon J Davies

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 35418096

Doi: 10.1186/s13068-022-02107-z

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Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging

Authors: Manning Y Huang, Meenakshi B Joshi, Michael J Boucher, Sujin Lee, Liza C Loza, Elizabeth A Gaylord, Tamara L Doering, Hiten D Madhani

Journal: Genetics

PubMed ID: 34791226

Doi: 10.1093/genetics/iyab180

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Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

Authors: María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M Valpuesta

Journal: Nat Commun

PubMed ID: 35013193

Doi: 10.1038/s41467-021-27657-y

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Heterogeneous Ribonucleoprotein A1 (hnRNPA1) Interacts with the Nucleoprotein of the Influenza a Virus and Impedes Virus Replication

Authors: Ramandeep Kaur, Jyoti Batra, Olga Stuchlik, Matthew S Reed, Jan Pohl, Suryaprakash Sambhara, Sunil Kumar Lal

Journal: Viruses

PubMed ID: 35215793

Doi: 10.3390/v14020199

Products & Services: Mammalian Expression

Multifunctional liposomal nanostructure-mediated siRNA/bortezomib co-delivery for SHARP1 knockdown in MLL-AF6 acute myeloid leukemia

Authors: Sameh A Mohammed, Yang Ju

Journal: Biomater Adv

PubMed ID: 35577689

Doi: 10.1016/j.msec.2022.112663

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Immune escape mutations selected by neutralizing antibodies in natural HIV-1 infection can alter coreceptor usage repertoire of the transmitted/founder virus

Authors: Manukumar Honnayakanahalli Marichannegowda, Hongshuo Song

Journal: Virology

PubMed ID: 35144109

Doi: 10.1016/j.virol.2022.01.010

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EID1 plays a protective role in early-onset pre-eclampsia via promoting proliferation and invasion in trophoblast cells

Authors: Ying Li, Jiuxiang Feng, Yue Bian, Wei Cheng, Chong Qiao

Journal: Folia Histochem Cytobiol

PubMed ID: 35038162

Doi: 10.5603/FHC.a2022.0001

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Human α-defensin 6 (HD6) suppresses CRC proliferation and metastasis through abolished EGF/EGFR signaling pathway

Authors: Po-Li Wei, Jang-Chun Lin, Chin-Sheng Hung, Precious Takondwa Makondi, Uyanga Batzorig, Tung-Cheng Chang, Chien-Yu Huang, Yu-Jia Chang

Journal: Int J Med Sci

PubMed ID: 34975297

Doi: 10.7150/ijms.64850

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Control of subunit stoichiometry in single-chain MspA nanopores

Authors: Mikhail Pavlenok, Luning Yu, Dominik Herrmann, Meni Wanunu, Michael Niederweis

Journal: Biophys J

PubMed ID: 35101416

Doi: 10.1016/j.bpj.2022.01.022

Products & Services: Gene Synthesis

Combinatorial therapy using RNAi and curcumin nano-architectures regresses tumors in breast and colon cancer models

Authors: Aviral Kumar, Amarnath Singam, Guruprasadh Swaminathan, Naresh Killi, Naveen Kumar Tangudu, Jedy Jose, Rathna Gundloori Vn, Lekha Dinesh Kumar

Journal: Nanoscale

PubMed ID: 34913453

Doi: 10.1039/d1nr04411g

Products & Services: Gene Synthesis

GroEL Chaperonin-Based Assay for Early Diagnosis of Scrub Typhus

Authors: Nitaya Indrawattana, Pisinee Aiumurai, Nawannaporn Sae-Lim, Watee Seesuay, Onrapak Reamtong, Manas Chongsa-Nguan, Wanpen Chaicumpa, Nitat Sookrung

Journal: Diagnostics (Basel)

PubMed ID: 35054302

Doi: 10.3390/diagnostics12010136

Products & Services: Gene Synthesis

Improved myocardial performance in infarcted rat heart by injection of disulfide-cross-linked chitosan hydrogels loaded with basic fibroblast growth factor

Authors: Bo Fu, Xiaobei Wang, Zhengda Chen, Nan Jiang, Zhigang Guo, Yuhui Zhang, Shaopeng Zhang, Xiankun Liu, Li Liu

Journal: J Mater Chem B

PubMed ID: 35014648

Doi: 10.1039/d1tb01961a

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Circular RNA circFGFR1 Functions as an Oncogene in Glioblastoma Cells through Sponging to hsa-miR-224-5p

Authors: Qian Zhang, Shan Chen, Yingwei Zhen, Peng Gao, Zhenyu Zhang, Hao Guo, Yong Wang

Journal: J Immunol Res

PubMed ID: 35059468

Doi: 10.1155/2022/7990251

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Lipoxin A and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway

Authors: Fen Xu, Jiamin Zhang, Xiaoyan Zhou, Hua Hao

Journal: Exp Cell Res

PubMed ID: 35026282

Doi: 10.1016/j.yexcr.2022.113025

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Cardiovascular-specific PSEN1 deletion leads to abnormalities in calcium homeostasis

Authors: Xiao-Wei Song, Feng Zhao, Jing Yang, Qing-Ning Yuan, Zhen-Yu Zeng, Ming Shen, Ying Tang, Mi Cao, Ya-Feng Shen, Song-Hua Li, Yong-Ji Yang, Hong Wu, Xian-Xian Zhao, Shu-Ting Hu

Journal: Cell Biol Int

PubMed ID: 34939719

Doi: 10.1002/cbin.11753

Products & Services: Protein and Antibody Isolation

Analysis of RNA-containing compartments by hybridization and proximity labeling in cultured human cells

Authors: Karen Yap, Tek Hong Chung, Eugene V Makeyev

Journal: STAR Protoc

PubMed ID: 35128480

Doi: 10.1016/j.xpro.2022.101139

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Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity

Authors: Swarna Bais, Abigail Norwillo, Gordon Ruthel, De'Broski R Herbert, Bruce D Freedman, Robert M Greenberg

Journal: Biochimie

PubMed ID: 34990770

Doi: 10.1016/j.biochi.2021.12.018

Products & Services: Gene Synthesis

Core-shell "loading-type" nanomaterials towards: Simultaneous imaging analysis of glutathione and microRNA

Authors: Lin-Lin Lu, Qin Zhang, Yu Gu, Xiang-Ling Li, Jing Jing Xie

Journal: Anal Chim Acta

PubMed ID: 35151402

Doi: 10.1016/j.aca.2022.339551

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Molecular Characterization of Mg-Chelatase CHLI Subunit in Pea ( L)

Authors: Cai-Jun Wu, Jie Wang, Jun Zhu, Jing Ren, You-Xin Yang, Tao Luo, Lu-Xi Xu, Qing-Hong Zhou, Xu-Feng Xiao, Yu-Xin Zhou, Sha Luo

Journal: Front Plant Sci

PubMed ID: 35145539

Doi: 10.3389/fpls.2022.821683

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Molecular Characterization of Mg-Chelatase CHLI Subunit in Pea ( L)

Authors: Cai-Jun Wu, Jie Wang, Jun Zhu, Jing Ren, You-Xin Yang, Tao Luo, Lu-Xi Xu, Qing-Hong Zhou, Xu-Feng Xiao, Yu-Xin Zhou, Sha Luo

Journal: Front Plant Sci

PubMed ID: 35145539

Doi: 10.3389/fpls.2022.821683

Products & Services: Gene Synthesis

Genome-Wide Identification and Expression Profiles of Genes in L

Authors: Meng Lu, Xiang-Xiao Meng, Yi-Ming Zhang, Xue-Wen Zhu, Jun Li, Wei-Qiang Chen, Hui-Hua Wan, Si-Fan Wang, Xue Cao, Wei Sun, Yao-Lei Mi, Jun-Wen Zhai

Journal: Cannabis Cannabinoid Res

PubMed ID: 35020417

Doi: 10.1089/can.2021.0153

Products & Services: Protein Tools

Introducing an Artificial Deazaflavin Cofactor in and

Authors: Misun Lee, Jeroen Drenth, Milos Trajkovic, René M de Jong, Marco W Fraaije

Journal: ACS Synth Biol

PubMed ID: 35044755

Doi: 10.1021/acssynbio.1c00552

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A phage parasite deploys a nicking nuclease effector to inhibit viral host replication

Authors: Kristen N LeGault, Zachary K Barth, Peter DePaola, Kimberley D Seed

Journal: Nucleic Acids Res

PubMed ID: 35066583

Doi: 10.1093/nar/gkac002

Products & Services: Gene Synthesis

High level production of stable human serum albumin in Pichia pastoris and characterization of the recombinant product

Authors: Nitu Maity, Avijeet S Jaswal, Ashwani Gautam, Vikram Sahai, Saroj Mishra

Journal: Bioprocess Biosyst Eng

PubMed ID: 34999948

Doi: 10.1007/s00449-021-02670-z

Products & Services: PCR Cloning and Subcloning

A transcriptional biosensor to monitor single cancer cell therapeutic responses by bioluminescence microscopy

Authors: Audrey Champagne, Pallavi Jain, Lauriane Vélot, Julie Riopel, Véronique Lefebvre, Bertrand Neveu, Frédéric Pouliot

Journal: Theranostics

PubMed ID: 34976196

Doi: 10.7150/thno.63744

Products & Services: Gene Synthesis

The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential

Authors: Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-Chen Wang, Lei Wang

Journal: Redox Biol

PubMed ID: 35077997

Doi: 10.1016/j.redox.2022.102244

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Inhibiting L1CAM Reverses Cisplatin Resistance of Triple Negative Breast Cancer Cells by Blocking AKT Signaling Pathway

Authors: Lu-Yao Zhang, Zhi-Xin Shen, Lu Guo

Journal: Cancer Invest

PubMed ID: 35040385

Doi: 10.1080/07357907.2021.2016801

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In silico, in vitro and in vivo safety evaluation of Limosilactobacillus reuteri strains ATCC PTA-126787 & ATCC PTA-126788 for potential probiotic applications

Authors: Dharanesh Gangaiah, Shrinivasrao P Mane, Nilesh R Tawari, Nallakannu Lakshmanan, Valerie Ryan, Alyssa Volland, Dwi Susanti, Milind Patel, Abraham Abouzeid, Emily B Helmes, Arvind Kumar

Journal: PLoS ONE

PubMed ID: 35081129

Doi: 10.1371/journal.pone.0262663

Products & Services: DNA Sequencing

SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability

Authors: Manami Hiraiwa, Kazuya Fukasawa, Takashi Iezaki, Hemragul Sabit, Tetsuhiro Horie, Kazuya Tokumura, Sayuki Iwahashi, Misato Murata, Masaki Kobayashi, Akane Suzuki, Gyujin Park, Katsuyuki Kaneda, Tomoki Todo, Atsushi Hirao, Mitsutoshi Nakada, Eiichi Hinoi

Journal: Commun Biol

PubMed ID: 35017630

Doi: 10.1038/s42003-021-02950-0

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Catalase () Gene Family in Wheat ( L): Evolution, Expression Pattern and Function Analysis

Authors: Yan Zhang, Lanjie Zheng, Liu Yun, Li Ji, Guanhui Li, Manchun Ji, Yong Shi, Xu Zheng

Journal: Int J Mol Sci

PubMed ID: 35008967

Doi: 10.3390/ijms23010542

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Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice

Authors: Forrest Jessop, Benjamin Schwarz, Dana Scott, Lydia M Roberts, Eric Bohrnsen, John R Hoidal, Catharine M Bosio

Journal: JCI Insight

PubMed ID: 35076028

Doi: 10.1172/jci.insight.155896

Products & Services: Protein and Antibody Isolation

Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells

Authors: Lakshana Sreenivasan, Ling Vicky Li, Pascal Leclair, Chinten James Lim

Journal: Cells

PubMed ID: 35159191

Doi: 10.3390/cells11030381

Products & Services: Recombinant Proteins

OsMYB103 is essential for tapetum degradation in rice

Authors: Ting Lei, Lisha Zhang, Ping Feng, Yang Liu, Wuzhong Yin, Lina Shang, Guanghua He, Nan Wang

Journal: Theor Appl Genet

PubMed ID: 35018498

Doi: 10.1007/s00122-021-04007-6

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Engineering His-Tagged Senecavirus A for One-Step Purification of Viral Antigens

Authors: Junhao Fan, Peiyu Xiao, Dongni Kong, Xinran Liu, Liang Meng, Tongqing An, Xuehui Cai, Haiwei Wang, Li Yu

Journal: Vaccines (Basel)

PubMed ID: 35214628

Doi: 10.3390/vaccines10020170

Products & Services: Recombinant Antibody Expression

Preclinical Evaluation of Chicken Egg Yolk Antibody (IgY) Anti-RBD Spike SARS-CoV-2-A Candidate for Passive Immunization against COVID-19

Authors: Hendris Wongso, Isa Mahendra, Wyanda Arnafia, Idar Idar, Muhammad Yusuf, Arifudin Achmad, Holis A Holik, Ahmad Kurniawan, Iim Halimah, Maula E Sriyani, Teguh H A Wibawa, Muhamad B Febrian, Yanuar Setiadi, Eva M Widyasari, Isti Daruwati, Crhisterra E Kusumaningrum, Toto Subroto

Journal: Vaccines (Basel)

PubMed ID: 35062789

Doi: 10.3390/vaccines10010128

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Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors

Authors: Daichao Wu, Alexander Kolesnikov, Rui Yin, Johnathan D Guest, Ragul Gowthaman, Anton Shmelev, Yana Serdyuk, Dmitry V Dianov, Grigory A Efimov, Brian G Pierce, Roy A Mariuzza

Journal: Nat Commun

PubMed ID: 35013235

Doi: 10.1038/s41467-021-27669-8

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Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity

Authors: Xiufei Chen, Wenjie Zhou, Ren-Hua Song, Shuang Liu, Shu Wang, Yujia Chen, Chao Gao, Chenxi He, Jianxiong Xiao, Lei Zhang, Tianxiang Wang, Peng Liu, Kunlong Duan, Zhouli Cheng, Chen Zhang, Jinye Zhang, Yiping Sun, Felix Jackson, Fei Lan, Yun Liu, Yanhui Xu, Justin Jong-Leong Wong, Pu Wang, Hui Yang, Yue Xiong, Tong Chen, Yan Li, Dan Ye

Journal: Sci Adv

PubMed ID: 35080973

Doi: 10.1126/sciadv.abl5220

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The Hinge Region of the Israeli Acute Paralysis Virus Internal Ribosome Entry Site Directs Ribosomal Positioning, Translational Activity, and Virus Infection

Authors: Mathew P Kirby, Ciara Stevenson, Liam J Worrall, Yihang Chen, Christina Young, Jisoo Youm, Natalie C J Strynadka, Douglas W Allan, Eric Jan

Journal: J Virol

PubMed ID: 35019716

Doi: 10.1128/JVI.01330-21

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