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Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway

Authors: Veronica Mutti, Federica Bono, Zaira Tomasoni, Leonardo Bontempi, Adele Guglielmi, Silvia Bolognin, Jens C Schwamborn, Cristina Missale, Chiara Fiorentini

Journal: Mol Neurobiol

PubMed ID: 35044626

Doi: 10.1007/s12035-022-02748-z

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Safety and Immunogenicity of the Third Booster Dose with Inactivated, Viral Vector, and mRNA COVID-19 Vaccines in Fully Immunized Healthy Adults with Inactivated Vaccine

Authors: Sitthichai Kanokudom, Suvichada Assawakosri, Nungruthai Suntronwong, Chompoonut Auphimai, Pornjarim Nilyanimit, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Ritthideach Yorsaeng, Donchida Srimuan, Thaksaporn Thatsanatorn, Sirapa Klinfueng, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Sittisak Honsawek, Yong Poovorawan

Journal: Vaccines (Basel)

PubMed ID: 35062747

Doi: 10.3390/vaccines10010086

Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

Authors: Stéphane Pillet, Prabhu S Arunachalam, Guadalupe Andreani, Nadia Golden, Jane Fontenot, Pyone Pyone Aye, Katharina Röltgen, Gabrielle Lehmicke, Philipe Gobeil, Charlotte Dubé, Sonia Trépanier, Nathalie Charland, Marc-André D'Aoust, Kasi Russell-Lodrigue, Christopher Monjure, Robert V Blair, Scott D Boyd, Rudolf P Bohm, Jay Rappaport, François Villinger, Nathalie Landry, Bali Pulendran, Brian J Ward

Journal: Cell Mol Immunol

PubMed ID: 34983950

Doi: 10.1038/s41423-021-00809-2

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Evolutionary Origin of the Carotenoid Cleavage Oxygenase Family in Plants and Expression of Pepper Genes in Response to Abiotic Stresses

Authors: Yixiu Yao, Li Jia, Yuan Cheng, Meiying Ruan, Qingjing Ye, Rongqing Wang, Zhuping Yao, Guozhi Zhou, Jia Liu, Jiahong Yu, Peng Zhang, Yuhe Yin, Weiping Diao, Hongjian Wan

Journal: Front Plant Sci

PubMed ID: 35126418

Doi: 10.3389/fpls.2021.792832

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N-glycolylneuraminic acid binding of avian and equine H7 influenza A viruses

Authors: Cindy M Spruit, Xueyong Zhu, Ilhan Tomris, María Ríos Carrasco, Alvin X Han, Frederik Broszeit, Roosmarijn van der Woude, Kim M Bouwman, Michel M T Luu, Keita Matsuno, Yoshihiro Sakoda, Colin A Russell, Ian A Wilson, Geert-Jan Boons, Robert P de Vries

Journal: J Virol

PubMed ID: 35044215

Doi: 10.1128/jvi.02120-21

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Improved yield, stability, and cleavage reaction of a novel tobacco etch virus protease mutant

Authors: Sergio Enríquez-Flores, José Ignacio De la Mora-De la Mora, Luis Antonio Flores-López, Nallely Cabrera, Cynthia Fernández-Lainez, Gloria Hernández-Alcántara, Carlos Enrique Guerrero-Beltrán, Gabriel López-Velázquez, Itzhel García-Torres

Journal: Appl Microbiol Biotechnol

PubMed ID: 35092453

Doi: 10.1007/s00253-022-11786-5

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Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay

Authors: Yusen Xiang, Guanglei Zhai, Yaozong Li, Mengge Wang, Xixiang Chen, Ruyu Wang, Hang Xie, Weidong Zhang, Guangbo Ge, Qian Zhang, Yechun Xu, Amedeo Caflisch, Jianrong Xu, Hongzhuan Chen, Lili Chen

Journal: Int J Biol Macromol

PubMed ID: 36521705

Doi: 10.1016/j.ijbiomac.2022.12.057

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Overcoming tumor heterogeneity by ex vivo arming of T cells using multiple bispecific antibodies

Authors: Jeong A Park, Nai-Kong V Cheung

Journal: J Immunother Cancer

PubMed ID: 35086947

Doi: 10.1136/jitc-2021-003771

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Plasmodium falciparum Kelch13 and its artemisinin-resistant mutants assemble as hexamers in solution: a SAXS data-driven modelling study

Authors: Nainy Goel, Kanika Dhiman, Nidhi Kalidas, Anwesha Mukhopadhyay, Fnu Ashish, Souvik Bhattacharjee

Journal: FEBS J

PubMed ID: 35092154

Doi: 10.1111/febs.16378

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Optimization of loop-mediated isothermal amplification (LAMP) assay for robust visualization in SARS-CoV-2 and emerging variants diagnosis

Authors: Zhen Luo, Chunhong Ye, Heng Xiao, Jialing Yin, Yicong Liang, Zhihui Ruan, Danju Luo, Daolong Gao, Qiuping Tan, Yongkui Li, Qiwei Zhang, Weiyong Liu, Jianguo Wu

Journal: Chem Eng Sci

PubMed ID: 35043022

Doi: 10.1016/j.ces.2022.117430

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Development and Clinical Validation of a Potential Penside Colorimetric Loop-Mediated Isothermal Amplification Assay of Porcine Circovirus Type 3

Authors: Jie Zhang, Miaomiao Li, Yunwen Ou, Danian Chen, Yaozhong Ding, Weibing Zhang, Yanjun Li, Qian Hou, Xiaoyun Li, Luoyi Zhou, Katarzyna Podgorska, Alexei D Zaberezhny, Anna Szczotka-Bochniarz, Yongsheng Liu, Yang Wang

Journal: Front Microbiol

PubMed ID: 35095787

Doi: 10.3389/fmicb.2021.758064

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Prognostic significance of a complement factor H autoantibody in early stage NSCLC

Authors: Elizabeth B Gottlin, Michael J Campa, Rikesh Gandhi, Ryan T Bushey, James E Herndon, Edward F Patz

Journal: Cancer Biomark

PubMed ID: 35068447

Doi: 10.3233/CBM-210355

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miR-505 inhibits replication of Borna disease virus 1 via inhibition of HMGB1-mediated autophagy

Authors: Yujie Guo, Xiaoyan Xu, Tian Tang, Lin Sun, Xiong Zhang, Xia Shen, Dan Li, Lixin Wang, Libo Zhao, Peng Xie

Journal: J Gen Virol

PubMed ID: 35060474

Doi: 10.1099/jgv.0.001713

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In vivo HSC gene therapy for SARS-CoV2 infection using a decoy receptor

Authors: Hongjie Wang, Chang Li, Adebimpe Obadan, Hannah Frizzell, Tien-Ying Hsiang, Sucheol Gil, Audrey Germond, Connie Fountain, Audrey Baldessari, Steve Roffler, Hans-Peter Kiem, Deborah Fuller, Andre Lieber

Journal: Hum Gene Ther

PubMed ID: 35057635

Doi: 10.1089/hum.2021.295

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An AAV vaccine targeting the RBD of the SARS-CoV-2 S protein induces effective neutralizing antibody titers in mice and canines

Authors: Fei Liu, Canbin Feng, Shiqi Xu, Qiang Wu, Jian Tang, Yan Chen, Ruisheng Xu, Fuliang Chen, Ni Gao, Zhengzheng Xu, Shihui Gu, Yang Lan, Haibo Zhou, Xinde Hu, Xiaojing Wang

Journal: Vaccine

PubMed ID: 35094871

Doi: 10.1016/j.vaccine.2022.01.030

Products & Services: Mammalian Expression

Backbone NMR assignment of the nucleotide binding domain of the Bacillus subtilis ABC multidrug transporter BmrA in the post-hydrolysis state

Authors: Victor Hugo Pérez Carrillo, Dania Rose-Sperling, Mai Anh Tran, Christoph Wiedemann, Ute A Hellmich

Journal: Biomol NMR Assign

PubMed ID: 34988902

Doi: 10.1007/s12104-021-10063-2

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Fukutin regulates tau phosphorylation and synaptic function: Novel properties of fukutin in neurons

Authors: Ryota Tsukui, Tomoko Yamamoto, Yukinori Okamura, Yoichiro Kato, Noriyuki Shibata

Journal: Neuropathology

PubMed ID: 35026860

Doi: 10.1111/neup.12797

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Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021

Authors: Shirley Ll Kwok, Samuel Ms Cheng, Jennifer Ns Leung, Kathy Leung, Cheuk-Kwong Lee, Js Malik Peiris, Joseph T Wu

Journal: Euro Surveill

PubMed ID: 35027105

Doi: 10.2807/1560-7917.ES.2022.27.2.2101197

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Downregulation of estrogen receptor-α36 expression attenuates metastasis of hepatocellular carcinoma cells

Authors: Ruobing Wang, Jiaming Chen, Haiyan Yu, Zhixuan Wei, Min Ma, Xueyan Ye, Weiqi Wu, Hongfei Chen, Zhengqi Fu

Journal: Environ Toxicol

PubMed ID: 35044086

Doi: 10.1002/tox.23469

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ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway

Authors: Xin Le, You-Fen Fan

Journal: J Plast Surg Hand Surg

PubMed ID: 34978504

Doi: 10.1080/2000656X.2021.2017944

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Homologous PB1 gene promotes the replication efficiency of avian influenza H7N4 candidate vaccine virus

Authors: Liqi Liu, Zi Li, Jianfang Zhou, Jia Liu, Xiyan Li, Weijuan Huang, Ning Xiao, Dayan Wang

Journal: Influenza Other Respir Viruses

PubMed ID: 35037399

Doi: 10.1111/irv.12954

Products & Services: Plasmid DNA Preparation

Embracing enzyme promiscuity with activity-based compressed biosensing

Authors: Brandon Alexander Holt, Hong Seo Lim, Anirudh Sivakumar, Hathaichanok Phuengkham, Melanie Su, McKenzie Tuttle, Yilin Xu, Haley Liakakos, Peng Qiu, Gabriel A Kwong

Journal: Cell Rep Methods

PubMed ID: 36814844

Doi: 10.1016/j.crmeth.2022.100372

Products & Services: Gene Synthesis

Genomic distribution of signal transducer and activator of transcription (STAT) family in colorectal cancer

Authors: Yanping Hu, Yifen Shen, Yang Zhao, Ying Tang, Chao Liu, Yongchun Gu, Tao Yang, Yihang Shen

Journal: Hum Cell

PubMed ID: 36284066

Doi: 10.1007/s13577-022-00815-0

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Multifunctional liposomal nanostructure-mediated siRNA/bortezomib co-delivery for SHARP1 knockdown in MLL-AF6 acute myeloid leukemia

Authors: Sameh A Mohammed, Yang Ju

Journal: Biomater Adv

PubMed ID: 35577689

Doi: 10.1016/j.msec.2022.112663

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Immune escape mutations selected by neutralizing antibodies in natural HIV-1 infection can alter coreceptor usage repertoire of the transmitted/founder virus

Authors: Manukumar Honnayakanahalli Marichannegowda, Hongshuo Song

Journal: Virology

PubMed ID: 35144109

Doi: 10.1016/j.virol.2022.01.010

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EID1 plays a protective role in early-onset pre-eclampsia via promoting proliferation and invasion in trophoblast cells

Authors: Ying Li, Jiuxiang Feng, Yue Bian, Wei Cheng, Chong Qiao

Journal: Folia Histochem Cytobiol

PubMed ID: 35038162

Doi: 10.5603/FHC.a2022.0001

Products & Services: Plasmid DNA Preparation

Human α-defensin 6 (HD6) suppresses CRC proliferation and metastasis through abolished EGF/EGFR signaling pathway

Authors: Po-Li Wei, Jang-Chun Lin, Chin-Sheng Hung, Precious Takondwa Makondi, Uyanga Batzorig, Tung-Cheng Chang, Chien-Yu Huang, Yu-Jia Chang

Journal: Int J Med Sci

PubMed ID: 34975297

Doi: 10.7150/ijms.64850

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Control of subunit stoichiometry in single-chain MspA nanopores

Authors: Mikhail Pavlenok, Luning Yu, Dominik Herrmann, Meni Wanunu, Michael Niederweis

Journal: Biophys J

PubMed ID: 35101416

Doi: 10.1016/j.bpj.2022.01.022

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Combinatorial therapy using RNAi and curcumin nano-architectures regresses tumors in breast and colon cancer models

Authors: Aviral Kumar, Amarnath Singam, Guruprasadh Swaminathan, Naresh Killi, Naveen Kumar Tangudu, Jedy Jose, Rathna Gundloori Vn, Lekha Dinesh Kumar

Journal: Nanoscale

PubMed ID: 34913453

Doi: 10.1039/d1nr04411g

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Activity-based protein profiling reveals dynamic substrate-specific cellulase secretion by saprotrophic basidiomycetes

Authors: Nicholas G S McGregor, Casper de Boer, Mikhaaeel Santos, Mireille Haon, David Navarro, Sybrin Schroder, Jean-Guy Berrin, Herman S Overkleeft, Gideon J Davies

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 35418096

Doi: 10.1186/s13068-022-02107-z

Products & Services: Gene Synthesis

Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging

Authors: Manning Y Huang, Meenakshi B Joshi, Michael J Boucher, Sujin Lee, Liza C Loza, Elizabeth A Gaylord, Tamara L Doering, Hiten D Madhani

Journal: Genetics

PubMed ID: 34791226

Doi: 10.1093/genetics/iyab180

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Reduced DNAJC3 Expression Affects Protein Translocation across the ER Membrane and Attenuates the Down-Modulating Effect of the Translocation Inhibitor Cyclotriazadisulfonamide

Authors: Eva Pauwels, Becky Provinciael, Anita Camps, Enno Hartmann, Kurt Vermeire

Journal: Int J Mol Sci

PubMed ID: 35054769

Doi: 10.3390/ijms23020584

Products & Services: Protein and Antibody Isolation

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

Authors: Yaw Bia Tan, Laura Sandra Lello, Xin Liu, Yee-Song Law, Congbao Kang, Julien Lescar, Jie Zheng, Andres Merits, Dahai Luo

Journal: Nucleic Acids Res

PubMed ID: 35037043

Doi: 10.1093/nar/gkab1302

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Immunogenicity of a recombinant VSV-Vectored SARS-CoV vaccine induced robust immunity in rhesus monkeys after single-dose immunization

Authors: Dan Shan, Xiaoyan Tang, Renqiang Liu, Dan Pan, Xijun Wang, Jinying Ge, Zhiyuan Wen, Zhigao Bu

Journal: Virol Sin

PubMed ID: 35234625

Doi: 10.1016/j.virs.2022.01.002

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Dimensionless parameter predicts bacterial prodrug success

Authors: Brandon Alexander Holt, McKenzie Tuttle, Yilin Xu, Melanie Su, Joachim J Røise, Xioajian Wang, Niren Murthy, Gabriel A Kwong

Journal: Mol Syst Biol

PubMed ID: 35005851

Doi: 10.15252/msb.202110495

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Investigating Constraints Along the Plant Secretory Pathway to Improve Production of a SARS-CoV-2 Spike Vaccine Candidate

Authors: Emmanuel Margolin, Matthew Verbeek, Warren de Moor, Ros Chapman, Ann Meyers, Georgia Schäfer, Anna-Lise Williamson, Edward Rybicki

Journal: Front Plant Sci

PubMed ID: 35058959

Doi: 10.3389/fpls.2021.798822

Products & Services: Mammalian Expression

Myricetin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting the Active and Locking the Inactive Conformations

Authors: Mei Dang, Liangzhong Lim, Amrita Roy, Jianxing Song

Journal: ACS Omega

PubMed ID: 35097276

Doi: 10.1021/acsomega.1c05569

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ROS-regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer

Authors: Jie Li, Cuimiao Zheng, Mingshuo Wang, Anna D Umano, Qingyuan Dai, Chunyu Zhang, Hua Huang, Qing Yang, Xianzhi Yang, Jingyi Lu, Wenfeng Pan, Bo Li, Shuzhong Yao, Chaoyun Pan

Journal: Oncogene

PubMed ID: 35039634

Doi: 10.1038/s41388-021-02149-x

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Heterologous Expression and Functional Characterization of CAP18 from

Authors: Mahla Nikpoor, Azadeh Lohrasbi-Nejad, Jafar Zolala

Journal: Rep Biochem Mol Biol

PubMed ID: 35291606

Doi: 10.52547/rbmb.10.4.622

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A combination of multiple autoantibodies is associated with the risk of Alzheimer's disease and cognitive impairment

Authors: Sung-Mi Shim, Young Ho Koh, Jong-Hoon Kim, Jae-Pil Jeon

Journal: Sci Rep

PubMed ID: 35079008

Doi: 10.1038/s41598-021-04556-2

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Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

Authors: Dhana G Gorasia, Ignacio Lunar Silva, Catherine A Butler, Maïalène Chabalier, Thierry Doan, Eric Cascales, Paul D Veith, Eric C Reynolds

Journal: Microbiol Spectr

PubMed ID: 35019767

Doi: 10.1128/spectrum.01602-21

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Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

Authors: María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M Valpuesta

Journal: Nat Commun

PubMed ID: 35013193

Doi: 10.1038/s41467-021-27657-y

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Heterogeneous Ribonucleoprotein A1 (hnRNPA1) Interacts with the Nucleoprotein of the Influenza a Virus and Impedes Virus Replication

Authors: Ramandeep Kaur, Jyoti Batra, Olga Stuchlik, Matthew S Reed, Jan Pohl, Suryaprakash Sambhara, Sunil Kumar Lal

Journal: Viruses

PubMed ID: 35215793

Doi: 10.3390/v14020199

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Selective Coimmobilization of His-Tagged Enzymes on Yttrium-Stabilized Zirconia-Based Membranes for Continuous Asymmetric Bioreductions

Authors: Daniel Andrés-Sanz, Eleftheria Diamanti, Desirè Di Silvo, Jonas Gurauskis, Fernando López-Gallego

Journal: ACS Appl Mater Interfaces

PubMed ID: 35020352

Doi: 10.1021/acsami.1c20738

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In silico, in vitro and in vivo safety evaluation of Limosilactobacillus reuteri strains ATCC PTA-126787 & ATCC PTA-126788 for potential probiotic applications

Authors: Dharanesh Gangaiah, Shrinivasrao P Mane, Nilesh R Tawari, Nallakannu Lakshmanan, Valerie Ryan, Alyssa Volland, Dwi Susanti, Milind Patel, Abraham Abouzeid, Emily B Helmes, Arvind Kumar

Journal: PLoS ONE

PubMed ID: 35081129

Doi: 10.1371/journal.pone.0262663

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SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability

Authors: Manami Hiraiwa, Kazuya Fukasawa, Takashi Iezaki, Hemragul Sabit, Tetsuhiro Horie, Kazuya Tokumura, Sayuki Iwahashi, Misato Murata, Masaki Kobayashi, Akane Suzuki, Gyujin Park, Katsuyuki Kaneda, Tomoki Todo, Atsushi Hirao, Mitsutoshi Nakada, Eiichi Hinoi

Journal: Commun Biol

PubMed ID: 35017630

Doi: 10.1038/s42003-021-02950-0

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Catalase () Gene Family in Wheat ( L): Evolution, Expression Pattern and Function Analysis

Authors: Yan Zhang, Lanjie Zheng, Liu Yun, Li Ji, Guanhui Li, Manchun Ji, Yong Shi, Xu Zheng

Journal: Int J Mol Sci

PubMed ID: 35008967

Doi: 10.3390/ijms23010542

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Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice

Authors: Forrest Jessop, Benjamin Schwarz, Dana Scott, Lydia M Roberts, Eric Bohrnsen, John R Hoidal, Catharine M Bosio