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Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury

Authors: Qing Hou, Weibo Le, Shuyan Kan, Jinsong Shi, Yue Lang, Zhihong Liu, Zhaohong Chen

Journal: Front Cell Dev Biol

PubMed ID: 35004680

Doi: 10.3389/fcell.2021.781792

Products & Services: Plasmid DNA Preparation

ASCVac-1, a Multi-Peptide Chimeric Vaccine, Protects Mice Against Infection

Authors: Ana Clara Gazzinelli-Guimarães, Denise Silva Nogueira, Chiara Cássia Oliveira Amorim, Fabrício Marcus Silva Oliveira, Anderson Coqueiro-Dos-Santos, Samuel Alexandre Pimenta Carvalho, Lucas Kraemer, Fernando Sérgio Barbosa, Vanessa Gomes Fraga, Flaviane Vieira Santos, Joseane Camilla de Castro, Remo Castro Russo, Milena Apetito Akamatsu, Paulo Lee Ho, Maria Elena Bottazzi, Peter J Hotez, Bin Zhan, Daniella Castanheira Bartholomeu, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara

Journal: Front Immunol

PubMed ID: 34992603

Doi: 10.3389/fimmu.2021.788185

Products & Services: Bacterial Expression

Protein acetylation regulates xylose metabolism during adaptation of Saccharomyces cerevisiae

Authors: Yong-Shui Tan, Li Wang, Ying-Ying Wang, Qi-En He, Zhi-Hua Liu, Zhen Zhu, Kai Song, Bing-Zhi Li, Ying-Jin Yuan

Journal: Biotechnol Biofuels

PubMed ID: 34920742

Doi: 10.1186/s13068-021-02090-x

Products & Services: Proteins, Expression, Isolation and Analysis

Boosting Vaccine-Elicited Respiratory Mucosal and Systemic COVID-19 Immunity in Mice With the Oral

Authors: Jianqing Xu, Zhihong Ren, Kangli Cao, Xianping Li, Jing Yang, Xuelian Luo, Lingyan Zhu, Xiangwei Wang, Longfei Ding, Junrong Liang, Dong Jin, Tingting Yuan, Lianfeng Li, Jianguo Xu

Journal: Front Nutr

PubMed ID: 35004816

Doi: 10.3389/fnut.2021.789242

Products & Services: Recombinant Antibody Expression

New lessons on TDP-43 from old N furzeri killifish

Authors: Alexandra Louka, Sara Bagnoli, Jakob Rupert, Benjamin Esapa, Gian Gaetano Tartaglia, Alessandro Cellerino, Annalisa Pastore, Eva Terzibasi Tozzini

Journal: Aging Cell

PubMed ID: 34939315

Doi: 10.1111/acel.13517

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Preclinical evaluation of a synthetic peptide vaccine against SARS-CoV-2 inducing multiepitopic and cross-reactive humoral neutralizing and cellular CD4 and CD8 responses

Authors: Belén Aparicio, Noelia Casares, Josune Egea, Marta Ruiz, Diana Llopiz, Sheila Maestro, Cristina Olagüe, Gloria González-Aseguinolaza, Cristian Smerdou, Ascensión López-Díaz de Cerio, Susana Inogés, Felipe Prósper, José R Yuste, Francisco Carmona-Torre, Gabriel Reina, Juan J Lasarte, Pablo Sarobe

Journal: Emerg Microbes Infect

PubMed ID: 34538222

Doi: 10.1080/22221751.2021.1978823

Products & Services: Mammalian Expression

Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia

Authors: Zhen-Tao Mo, Jie Zheng, Yu-Ling Liao

Journal: Pharm Biol

PubMed ID: 34711127

Doi: 10.1080/13880209.2021.1991959

Products & Services: Plasmid DNA Preparation

Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1

Authors: Kyung-Mi Choi, Jung Hak Kim, Xiangmudong Kong, Meltem Isik, Jin Zhang, Hee-Woong Lim, John C Yoon

Journal: Cell Rep

PubMed ID: 34910916

Doi: 10.1016/j.celrep.2021.110104

Products & Services: Catalog Antibody

VLDLR and ApoER2 are receptors for multiple alphaviruses

Authors: Lars E Clark, Sarah A Clark, ChieYu Lin, Jianying Liu, Adrian Coscia, Katherine G Nabel, Pan Yang, Dylan V Neel, Hyo Lee, Vesna Brusic, Iryna Stryapunina, Kenneth S Plante, Asim A Ahmed, Flaminia Catteruccia, Tracy L Young-Pearse, Isaac M Chiu, Paula Montero Llopis, Scott C Weaver, Jonathan Abraham

Journal: Nature

PubMed ID: 34929721

Doi: 10.1038/s41586-021-04326-0

Products & Services: Mammalian Expression

Bombyx mori Nucleopolyhedrovirus (BmNPV) Induces G2/M Arrest to Promote Viral Multiplication by Depleting

Authors: Qin Xiao, Zhan-Qi Dong, Yan Zhu, Qian Zhang, Xiu Yang, Miao Xiao, Peng Chen, Cheng Lu, Min-Hui Pan

Journal: Insects

PubMed ID: 34940186

Doi: 10.3390/insects12121098

Products & Services: Custom Vector Construction

Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens

Authors: Ryuta Uraki, Masaki Imai, Mutsumi Ito, Hiroaki Shime, Mizuyu Odanaka, Moe Okuda, Yoshihiro Kawaoka, Sayuri Yamazaki

Journal: PLoS Pathog

PubMed ID: 34882757

Doi: 10.1371/journal.ppat.1010085

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Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation

Authors: Yonghong Luo, Yanhong Guo, Huilun Wang, Minzhi Yu, Kristen Hong, Dan Li, Ruiting Li, Bo Wen, Die Hu, Lin Chang, Jifeng Zhang, Bo Yang, Duxin Sun, Anna S Schwendeman, Y Eugene Chen

Journal: EBioMedicine

PubMed ID: 34879325

Doi: 10.1016/j.ebiom.2021.103725

Products & Services: Peptide Synthesis

Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein

Authors: Lawrence T Wang, Lais S Pereira, Patience K Kiyuka, Arne Schön, Neville K Kisalu, Rachel Vistein, Marlon Dillon, Brian G Bonilla, Alvaro Molina-Cruz, Carolina Barillas-Mury, Joshua Tan, Azza H Idris, Joseph R Francica, Robert A Seder

Journal: PLoS Pathog

PubMed ID: 34871332

Doi: 10.1371/journal.ppat.1010133

Products & Services: Peptide Synthesis

Oxidation of Various Kraft Lignins with a Bacterial Laccase Enzyme

Authors: Sebastian A Mayr, Raditya Subagia, Renate Weiss, Nikolaus Schwaiger, Hedda K Weber, Johannes Leitner, Doris Ribitsch, Gibson S Nyanhongo, Georg M Guebitz

Journal: Int J Mol Sci

PubMed ID: 34884966

Doi: 10.3390/ijms222313161

Products & Services: Stable Cell Lines

A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation

Authors: Christopher E Smith, Yien Che Tsai, Yu-He Liang, Domarin Khago, Jennifer Mariano, Jess Li, Sergey G Tarasov, Emma Gergel, Borong Tsai, Matthew Villaneuva, Michelle E Clapp, Valentin Magidson, Raj Chari, R Andrew Byrd, Xinhua Ji, Allan M Weissman

Journal: PLoS Biol

PubMed ID: 34879065

Doi: 10.1371/journal.pbio.3001474

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Metabolic drug survey highlights cancer cell dependencies and vulnerabilities

Authors: Tea Pemovska, Johannes W Bigenzahn, Ismet Srndic, Alexander Lercher, Andreas Bergthaler, Adrián César-Razquin, Felix Kartnig, Christoph Kornauth, Peter Valent, Philipp B Staber, Giulio Superti-Furga

Journal: Nat Commun

PubMed ID: 34907165

Doi: 10.1038/s41467-021-27329-x

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Calibration of two validated SARS-CoV-2 pseudovirus neutralization assays for COVID-19 vaccine evaluation

Authors: Yunda Huang, Oleg Borisov, Jia Jin Kee, Lindsay N Carpp, Terri Wrin, Suqin Cai, Marcella Sarzotti-Kelsoe, Charlene McDanal, Amanda Eaton, Rolando Pajon, John Hural, Christine M Posavad, Katherine Gill, Shelly Karuna, Lawrence Corey, M Juliana McElrath, Peter B Gilbert, Christos J Petropoulos, David C Montefiori

Journal: Sci Rep

PubMed ID: 34907214

Doi: 10.1038/s41598-021-03154-6

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Identification and Characterization Analysis of Transient Receptor Potential Mucolipin Protein of Fallén

Authors: Haitao Wang, Yan Dong, Baijie Wan, Yinghua Ji, Qiufang Xu

Journal: Insects

PubMed ID: 34940195

Doi: 10.3390/insects12121107

Products & Services: Catalog Peptides

The parasitophorous vacuole nutrient channel is critical for drug access in malaria parasites and modulates the artemisinin resistance fitness cost

Authors: Paolo Mesén-Ramírez, Bärbel Bergmann, Mourad Elhabiri, Lei Zhu, Heidrun von Thien, Carolina Castro-Peña, Tim-Wolf Gilberger, Elisabeth Davioud-Charvet, Zbynek Bozdech, Anna Bachmann, Tobias Spielmann

Journal: Cell Host Microbe

PubMed ID: 34863371

Doi: 10.1016/j.chom.2021.11.002

Products & Services: Stable Cell Lines

The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target

Authors: Gergely Rona, Andras Zeke, Bearach Miwatani-Minter, Maren de Vries, Ramanjit Kaur, Austin Schinlever, Sheena Faye Garcia, Hailey V Goldberg, Hui Wang, Thomas R Hinds, Fabrice Bailly, Ning Zheng, Philippe Cotelle, Didier Desmaële, Nathaniel R Landau, Meike Dittmann, Michele Pagano

Journal: Cell Death Differ

PubMed ID: 34862481

Doi: 10.1038/s41418-021-00900-1

Products & Services: Codon Optimization

Development and characterization of efficient xylose utilization strains of Zymomonas mobilis

Authors: Jiyun Lou, Jingwen Wang, Yongfu Yang, Qing Yang, Runxia Li, Mimi Hu, Qiaoning He, Jun Du, Xia Wang, Mian Li, Shihui Yang

Journal: Biotechnol Biofuels

PubMed ID: 34863266

Doi: 10.1186/s13068-021-02082-x

Products & Services: Gene Synthesis

GR-mediated transcriptional regulation of mA metabolic genes contributes to diet-induced fatty liver in hens

Authors: Yue Feng, Yanlin Li, Wenduo Jiang, Yun Hu, Yimin Jia, Ruqian Zhao

Journal: J Anim Sci Biotechnol

PubMed ID: 34872591

Doi: 10.1186/s40104-021-00642-7

Products & Services: Custom DNA/RNA Oligos

Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2

Authors: Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde

Journal: Commun Biol

PubMed ID: 34853399

Doi: 10.1038/s42003-021-02866-9

Products & Services: Gene Synthesis

Immune responses in multiple hosts to Nucleocapsid Protein (NP) of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

Authors: Elif Karaaslan, Nesibe Selma Çetin, Merve Kalkan-Yazıcı, Sevde Hasanoğlu, Faruk Karakeçili, Aykut Özdarendeli, Ahmet Kalkan, Ali Osman Kılıç, Mehmet Ziya Doymaz

Journal: PLoS Negl Trop Dis

PubMed ID: 34851958

Doi: 10.1371/journal.pntd.0009973

Products & Services: Bacterial Expression

Division of labor between SOS and PafBC in mycobacterial DNA repair and mutagenesis

Authors: Oyindamola O Adefisayo, Pierre Dupuy, Astha Nautiyal, James M Bean, Michael S Glickman

Journal: Nucleic Acids Res

PubMed ID: 34871411

Doi: 10.1093/nar/gkab1169

Products & Services: Polyclonal Antibody Services

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

Authors: Ioanna A Rota, Adam E Handel, Stefano Maio, Fabian Klein, Fatima Dhalla, Mary E Deadman, Stanley Cheuk, Joseph A Newman, Yale S Michaels, Saulius Zuklys, Nicolas Prevot, Philip Hublitz, Philip D Charles, Athina Soragia Gkazi, Eleni Adamopoulou, Waseem Qasim, Edward Graham Davies, Imelda Hanson, Alistair T Pagnamenta, Carme Camps, Helene M Dreau, Andrea White, Kieran James, Roman Fischer, Opher Gileadi, Jenny C Taylor, Tudor Fulga, B Christoffer Lagerholm, Graham Anderson, Erdinc Sezgin, Georg A Holländer

Journal: Sci Adv

PubMed ID: 34860543

Doi: 10.1126/sciadv.abj9247

Mining Marine Metagenomes Revealed a Quorum-Quenching Lactonase with Improved Biochemical Properties That Inhibits the Food Spoilage Bacterium Pseudomonas fluorescens

Authors: Rami Haramati, Shlomit Dor, David Gurevich, Doron Levy, Dekel Freund, Giora Rytwo, Itai Sharon, Livnat Afriat-Jurnou

Journal: Appl Environ Microbiol

PubMed ID: 34910563

Doi: 10.1128/AEM.01680-21

Products & Services: Gene Synthesis

Isolation of Healthy F4/80+ Macrophages from Embryonic day E135 Mouse Fetal Liver Using Magnetic Nanoparticles for Single Cell Sequencing

Authors: Kaustav Mukherjee, James J Bieker

Journal: Bio Protoc

PubMed ID: 35005088

Doi: 10.21769/BioProtoc.4243

Products & Services: Catalog Peptides

Long non‑coding RNA LINC01748 exerts carcinogenic effects in non‑small cell lung cancer cell lines by regulating the microRNA‑520a‑5p/HMGA1 axis

Authors: Yinling Tan, Fengxia Xu, Lingling Xu, Jianying Cui

Journal: Int J Mol Med

PubMed ID: 34970695

Doi: 10.3892/ijmm.2021.5077

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Preparation and characterization of a fully human monoclonal antibody specific for human tumor necrosis factor alpha

Authors: Xinmei Liao, Hui Liang, Jian Pan, Qian Zhang, Jiaqi Niu, Cuili Xue, Jian Ni, Daxiang Cui

Journal: Bioengineered

PubMed ID: 34886761

Doi: 10.1080/21655979.2021.1967710

Products & Services: Proteins, Expression, Isolation and Analysis

Fourier-Transform Approach for Reconstructing Macromolecular Mass Defect Profiles

Authors: Andrew K Swansiger, Michael T Marty, James S Prell

Journal: J Am Soc Mass Spectrom

PubMed ID: 34913687

Doi: 10.1021/jasms.1c00317

Products & Services: Recombinant Proteins

HMGA2 promotes the migration and invasion of gallbladder cancer cells and HMGA2 knockdown inhibits angiogenesis via targeting VEGFA

Authors: Jun Yan, Peng Dai, Xueliang Qin, Yanping He, Yu Zhang

Journal: Mol Med Rep

PubMed ID: 34913073

Doi: 10.3892/mmr.2021.12570

Products & Services: Plasmid DNA Preparation

Development of a recombinant nucleocapsid protein-based ELISA for the detection of IgM and IgG antibodies to SARS-CoV-2

Authors: Maryam Ranjbar, Marzieh Asadi, Marjan Nourigorji, Bahador Sarkari, Zohreh Mostafavi-Pour, Kamiar Zomorodian, Zahra Shabaninejad, Mortaza Taheri-Anganeh, Amir Maleksabet, Mohsen Moghadami, Amir Savardashtaki

Journal: Biotechnol Appl Biochem

PubMed ID: 34965611

Doi: 10.1002/bab.2308

Products & Services: GenParts™ DNA Fragments

Loss of Neutralizing Antibody Response to mRNA Vaccination against SARS-CoV-2 Variants: Differing Kinetics and Strong Boosting by Breakthrough Infection

Authors: John P Evans, Cong Zeng, Claire Carlin, Gerard Lozanski, Linda J Saif, Eugene M Oltz, Richard J Gumina, Shan-Lu Liu

Journal: biorxiv

PubMed ID: 34909777

Doi: 10.1101/2021.12.06.471455

Products & Services: Stable Cell Lines

Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-κB into the nucleus

Authors: Jiao Lan, Ke Li, Austin Gresham, Jifei Miao

Journal: Eur J Pharmacol

PubMed ID: 34896110

Doi: 10.1016/j.ejphar.2021.174693

Products & Services: Endotoxin Detection & Removal System

Fine-tuning of pathogenesis-related protein 1 (PR1) activity by the melatonin biosynthetic enzyme ASMT2 in defense response to cassava bacterial blight

Authors: Jingru Guo, Yujing Bai, Yunxie Wei, Yabin Dong, Hongqiu Zeng, Russel J Reiter, Haitao Shi

Journal: J Pineal Res

PubMed ID: 34936113

Doi: 10.1111/jpi.12784

Products & Services: Proteins, Expression, Isolation and Analysis

Comparative analysis of mussel foot protein 3B co-expressed with tyrosinases provides a potential adhesive biomaterial

Authors: Lin Yao, Xinyi Wang, Rui Xue, Hong Xu, Rui Wang, Lujia Zhang, Sha Li

Journal: Int J Biol Macromol

PubMed ID: 34896153

Doi: 10.1016/j.ijbiomac.2021.11.208

Products & Services: Bacterial Expression

Deferasirox combination with eltrombopag shows anti-myelodysplastic syndrome effects by enhancing iron deprivation-related apoptosis

Authors: Lei Huang, Mengyue Tian, Zhaoyun Liu, Chunyan Liu, Rong Fu

Journal: J Investig Med

PubMed ID: 34921125

Doi: 10.1136/jim-2021-002147

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Cryopreservation of network bioactivity and multi-lineage stromal cell differentiation potential within three-dimensional synthetic hydrogels

Authors:

Journal: Cryobiology

PubMed ID: 34922883

Doi: 10.1016/j.cryobiol.2021.12.003

Products & Services: Molecular Biology Reagents

Developing a secretory AcGFP1-based IRES expression system for efficient production of mammalian recombinant proteins

Authors: Zhongcheng Zou, Matthew Spencer, Peter D Sun

Journal: Protein Expr Purif

PubMed ID: 34920134

Doi: 10.1016/j.pep.2021.106029

Products & Services: Codon Optimization

Structural Insight into the Mechanism of PALB2 Interaction with MRG15

Authors: Jennifer Redington, Jaigeeth Deveryshetty, Lakshmi Kanikkannan, Ian Miller, Sergey Korolev

Journal: Genes (Basel)

PubMed ID: 34946951

Doi: 10.3390/genes12122002

Products & Services: Mutant Libraries

Reversible myocardial injury aggravated by complex arrhythmias in three Toxoplasma gondii-positive dogs

Authors: Giovanni Romito, Elena Venturelli, Vanna Tintorri, Mario Cipone

Journal: J Vet Med Sci

PubMed ID: 34955461

Doi: 10.1292/jvms.21-0571

Products & Services: PCR and Cloning

Engineered Sphingomonas sp KT-1 PahZ1 monomers efficiently degrade poly(aspartic acid)

Authors: Timothy Lamantia, Amanda Jansch, Justin D Marsee, Mitch H Weiland, Justin M Miller

Journal: Biophys Chem

PubMed ID: 34953381

Doi: 10.1016/j.bpc.2021.106745

Products & Services: Mutagenesis Services

CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study

Authors: Yazdan Rahmati, Hasan Mollanoori, Sajad Najafi, Sajjad Esmaeili, Mohammad Reza Alivand

Journal: BMC Pediatr

PubMed ID: 34895171

Doi: 10.1186/s12887-021-03003-5

Products & Services: Molecular Biology Tools

Hydroxysafflor yellow A inhibits the proliferation, migration, and invasion of colorectal cancer cells through the PPARγ/PTEN/Akt signaling pathway

Authors: Dan Su, Chunye Lv

Journal: Bioengineered

PubMed ID: 34889713

Doi: 10.1080/21655979.2021.2009965

Products & Services: Gene Synthesis

Increased sensitivity of gp210 autoantibody detection using a newly designed gp210 antigen

Authors: Jing Xu, Haoyi Zhang, Chan Wang, Peng Jiang, Chongxu Han, Yaping Dai, Fang Qiu, Yuhua Gong, Yuzhang Jiang, Ping Xu, Mingming Zhang, Luyao Zhang, Xingjuan Shi, Sufang Chen, Ye Tian, Michael F Seldin, M Eric Gershwin, Xiangdong Liu, Li Li

Journal: J Immunol Methods

PubMed ID: 34971632

Doi: 10.1016/j.jim.2021.113211

Products & Services: Mammalian Expression

Vulnerable exons, like ACADM exon 5, are highly dependent on maintaining a correct balance between splicing enhancers and silencers

Authors: Lise L Holm, Thomas K Doktor, Michael B Hansen, Ulrika S S Petersen, Brage S Andresen

Journal: Hum Mutat

PubMed ID: 34923709

Doi: 10.1002/humu.24321

Products & Services: Mutagenesis Services

Increased sensitivity of gp210 autoantibody detection using a newly designed gp210 antigen

Journal: J Immunol Methods

PubMed ID: 34971632

Doi: 10.1016/j.jim.2021.113211

Products & Services: Mammalian Expression

CTLA4-Ig treatment induces M1-M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients

Authors: Maurizio Cutolo, Stefano Soldano, Emanuele Gotelli, Paola Montagna, Rosanna Campitiello, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Samuele Tardito

Journal: Arthritis Res Ther

PubMed ID: 34952630

Doi: 10.1186/s13075-021-02691-9

Products & Services: Proteins, Expression, Isolation and Analysis

The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism

Authors: Jennifer A Buffa, Kymberleigh A Romano, Matthew F Copeland, David B Cody, Weifei Zhu, Rachel Galvez, Xiaoming Fu, Kathryn Ward, Marc Ferrell, Hong J Dai, Sarah Skye, Ping Hu, Lin Li, Mirjana Parlov, Amy McMillan, Xingtao Wei, Ina Nemet, Robert A Koeth, Xinmin S Li, Zeneng Wang, Naseer Sangwan, Adeline M Hajjar, Mohammed Dwidar, Taylor L Weeks, Nathalie Bergeron, Ronald M Krauss, W H Wilson Tang, Federico E Rey, Joseph A DiDonato, Valentin Gogonea, G Frank Gerberick, Jose Carlos Garcia-Garcia, Stanley L Hazen

Journal: Nat Microbiol

PubMed ID: 34949826

Doi: 10.1038/s41564-021-01010-x

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